##### Table of Contents





UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





FORM 10-K/A





(Mark One)

|x | Annual report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
|- | ------------------------------------------------------------------------------------

| | For the fiscal year ended December 31, 2009
| | -------------------------------------------

OR



| ̈ | Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
|- | ----------------------------------------------------------------------------------------

| | For the transition period from              to
| | ----------------------------------------------

Commission File Number:
000-21699





VIROPHARMA INCORPORATED

(Exact name of registrant as specified in its charter)







|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|Delaware                                                       |  | 23-2789550                          
|(State or other jurisdiction of
incorporation or organization) |  | (I.R.S. Employer Identification No.)



|                                         |  |           
|---------------------------------------- |  | ----------
|730 Stockton Drive, Exton, Pennsylvania  |  | 19341     
|(Address of principal executive offices) |  | (Zip Code)

Registrants telephone number, including area code: 610-458-7300





Securities registered pursuant to Section 12(b) of the Act:



|                               |  |                                           
|------------------------------ |  | ------------------------------------------
|Title of each class:           |  | Name of each exchange on which registered:
|Common Stock, par value $0.002 |  | The NASDAQ Stock Market LLC               

Securities registered pursuant to Section 12(g) of the Act:

Title of each class: None





Indicate by
check mark if the registrant is a well-known seasoned issuer, as defined by Rule 405 of the Securities Act.    Yes  x    No   ̈

Indicate by check mark if the registrant is not required to file reports pursuant
to Section 13 or Section 15(d) of the Exchange Act.    Yes   ̈    No  x

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the
Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports) and (2) has been subject to such filing requirements for the past 90
days.    Yes  x    No   ̈

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every
Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such
files).    Yes   ̈    No   ̈

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will
not be contained, to the best of registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this
Form 10-K.  x

Indicate by check mark whether the registrant is
a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of accelerated filer and large accelerated filer in Rule 12b-2 of the Exchange Act. (Check one):

Large Accelerated
Filer   ̈            Accelerated
Filer  x            Non-accelerated
filer   ̈            Smaller Reporting Company   ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange
Act).    Yes   ̈    No  x

The approximate aggregate market value of the voting stock held by non-affiliates of the registrant was approximately $401.7 million as
of June 30, 2009, based upon the closing sale price per share of the Common Stock as quoted on the Global Market segment of the NASDAQ Stock Market on that date.

The number of shares of the registrants Common Stock outstanding as of February 19, 2010 was 77,480,094 shares.









---

##### Table of Contents

VIROPHARMA INCORPORATED

FORM 10-K ANNUAL REPORT

For Fiscal Year Ended December 31, 2009

TABLE OF
CONTENTS



|                                            |  |                                            |    |      |    | 
|------------------------------------------- |  | ------------------------------------------ | -- | ---- | -- | 
|                                            |  |                                            |    | Page |   
|PART I                                      |  |                                            |    |      |    | 
|Item 1.                                     |  | Business                                   |    |      | 1  | 
|PART III                                    |  |                                            |    |      |    | 
|Item 11.                                    |  | Executive Compensation                     |    |      | 20 | 
|PART IV                                     |  |                                            |    |      |    | 
|Item 15.                                    |  | Exhibits and Financial Statement Schedules |    |      |    | 
|Signatures                                  |  |                                            | 38 |     
|                                            | 
|Index to Financial Statements and Schedules |  |                                            |    |     

ViroPharma, ViroPharma plus the design, Cinryze, CinryzeSolutions and
Vancocin are trademarks and service marks of ViroPharma or its licensors. We have obtained trademark registration in the United States for the marks in connection with certain products and services. All other brand names or trademarks
appearing in this Annual Report on Form 10-K are the property of others.

Unless the context requires otherwise, references in this
report to we, our, us, Company and ViroPharma refer to ViroPharma Incorporated and its subsidiaries.



---

##### Table of Contents

EXPLANATORY NOTE

ViroPharma Incorporated (the Company) is filing this Amendment No. 1 to its Annual Report on Form 10-K for the year
ended December 31, 2009 (the Form 10-K) in response to comments received from the Securities and Exchange Commission regarding a request for additional disclosure of certain portions of Items 1 and 11 originally filed with the Form
10-K. This Amendment No. 1 to Annual Report on Form 10-K/A (this Amendment) is being filed solely to (i) add disclosure regarding a license agreement the Company entered into with Dr. Dale Gerding of the Hines VA in
February 2006, including certain royalty payments and milestone payments that we will be obligated to pay Dr. Gerding if and when certain regulatory developments are achieved, which disclosures may be found in the first paragraph of page 5 and
(ii) expand disclosure in Compensation Discussion and Analysis to include the individual objectives, and certain other various factors, used to determine certain executive officers annual performance-based bonuses, which disclosure may be
found on pages 23-26. In addition, as required by Rule 12b-15 under the Securities Exchange Act of 1934, as amended, new certifications by our principal executive officer and principal financial officer are filed as exhibits to this Amendment.

Except as described above, this Amendment does not reflect events occurring after the filing of the original Form 10-K and no
revisions are being made pursuant to this Amendment to the Companys financial statements or any other disclosure contained in the Form 10-K.

PART I



|ITEM 1. | BUSINESS
|------- | --------

ViroPharma
Incorporated and subsidiaries is a global biotechnology company dedicated to the development and commercialization of products that address serious diseases, with a focus on products used by physician specialists or in hospital settings. We have two
marketed products and two development programs. We intend to grow through sales of our marketed products,
CinryzeTMand Vancocin®, through continued development of our product pipeline, expansion of sales of Cinryze into additional territories
and through potential acquisition or licensing of products or acquisition of companies.

We market and sell Cinryze in the United States for
routine prophylaxis against angioedema attacks in adolescent and adult patients with hereditary angioedema (HAE). Cinryze is a C1 esterase inhibitor therapy for routine prophylaxis against HAE, also known as C1 inhibitor (C1-INH) deficiency, a rare,
severely debilitating, life-threatening genetic disorder. Cinryze was obtained in October 2008, when we completed our acquisition of Lev Pharmaceuticals, Inc. (Lev). On January 8, 2010 we obtained expanded rights to commercialize Cinryze
and future C1-INH derived products in certain European countries and other territories throughout the world (as described in the strategic relationships section) as well as rights to develop future C1-INH derived products for additional indications.
We intend to seek to commercialize Cinryze in Europe in 2011 in countries which we have distribution rights. We are currently evaluating our commercialization plans in additional territories. We also intend to conduct studies to identify further
therapeutic uses and expand the labeled indication for Cinryze to potentially include other C1 mediated diseases as well as new modes of administration.

We also market and sell Vancocin HCl capsules, the oral capsule formulation of vancomycin hydrochloride, in the U.S. and its territories. Vancocin is a potent antibiotic approved by the U.S. Food and Drug
Administration, or FDA, to treat antibiotic-associated pseudomembranous colitis caused by Clostridium difficileinfection (CDI), or C. difficile, and enterocolitis caused by Staphylococcus aureus, including methicillin-resistant
strains.

We currently have two development programs, C1 esterase inhibitor [human] to identify further therapeutic uses and potential
additional indications and other modes of administration for the treatment of HAE and other C1 mediated diseases and a non-toxigenic strain of C. difficile (NTCD) for the treatment and prevention of CDI. On August 6, 2009 we announced that
dosing has begun in the Phase 1 clinical trial for NTCD. The Phase 1 study will determine the safety and tolerability of NTCD dosed orally as a single and repeat escalating doses in healthy young and older adults. On February 9, 2009, we
announced that our Phase 3 trial evaluating maribavir used as prophylaxis in allogeneic stem cell, or bone marrow, transplant (SCT) patients did not achieve its primary endpoint. In the primary analysis, there was no statistically significant
difference between maribavir and placebo in reducing the rate of CMV disease. Additionally, on February 13, 2009, we announced that enrollment in our Phase 3 trial evaluating maribavir in liver transplant patients was discontinued and that all
patients on study drug were moved to the current standard of care. We continue to evaluate our maribavir program in light of the Phase 3 clinical trial results.

We licensed the U.S. and Canadian rights for a further product development candidate, an intranasal formulation of pleconaril, to Merck & Co., Inc. (Merck) for the treatment of picornavirus
infections.

We intend to continue to evaluate in-licensing or other opportunities to acquire products in development, or those that are
currently on the market. We plan to seek products that treat serious or life threatening illnesses, which treat high unmet medical needs, which require limited commercial infrastructure, and that have the potential to provide both top and bottom
line growth.



1



---

##### Table of Contents

We were incorporated in Delaware in September 1994 and commenced operations in December 1994. Our executive
offices are located at 730 Stockton Drive, Exton, Pennsylvania 19341, our telephone number is 610-458-7300 and our website address is www.viropharma.com. Information contained on our website is not incorporated into this Annual Report on Form 10-K
or any other filings we make with the SEC.

The following chart generally describes our approved products:



|                                                                      |  |                                                             |  |                           |  |                                         |  |                         |  |                  
|--------------------------------------------------------------------- |  | ----------------------------------------------------------- |  | ------------------------- |  | --------------------------------------- |  | ----------------------- |  | -----------------
|                                                                      |  | Product                                                     |  | Marketplace               |  | Disease                                 |  | Program Indication      |  | Product Status   
|                                                                      |  | Cinryze - IV                                                |  | US                        |  | HAE                                     |  | Prophylaxis             |  | Marketed         
|                                                                      |  |                                                             |  |                           | 
|                                                                      |  | Vancocin                                                    |  | US                        |  | CDI                                     |  | Treatment               |  | Marketed         
|                                                                     
|The following chart generally describes our investigational products:
|                                                                      |  |                                                             |  |                           | 
|                                                                      |  | Product                                                     |  | Marketplace               |  | Disease                                 |  | Proposed Indication     |  | Product Status   
|                                                                      |  | C1 esterase inhibitor [human]  IV                          |  | EU                        |  | HAE                                     |  | Prophylaxis andacute    |  | Prefiling        
|                                                                      |  |                                                             |  |                           | 
|                                                                      |  | C1 esterase inhibitor [human]  IV                          |  | ROW*                      |  | HAE                                     |  | Prophylaxis andacute    |  | Prefiling        
|                                                                      |  |                                                             |  |                           | 
|                                                                      |  | Non-toxigenic strain of C. difficile (NTCD)                 |  | Worldwide                 |  | CDI                                     |  | Treatment andprevention |  | Phase 1          
|                                                                      |  |                                                             |  |                           | 
|                                                                      |  | C1 esterase inhibitor [human]  subcutaneous administration |  | Worldwide                 |  | HAE                                     |  | Prophylaxis             |  | Phase 1          
|                                                                      |  |                                                             |  |                          
|                                                                      |  | C1 esterase inhibitor [human]  IV                          |  | Worldwide                 |  | Additional indications under evaluation |  | Preclincial            
|                                                                      |  |                                                             |  |                           | 
|                                                                      |  | Maribavir                                                   |  | Worldwide,other thanJapan |  | CMV                                     |  | Treatment andprevention |  | EvaluatingProgram



|* | ROW is defined in the Strategic Relationships section of the document.
|- | ----------------------------------------------------------------------

Marketed Products

Cinryze

The FDA granted approval for Cinryze in October 2008 for routine prophylaxis against attacks in adolescent and adult patients with hereditary angioedema
(HAE). HAE is a genetic disorder characterized by episodes of edema (swelling) in the extremities, face, abdomen, and airway passages. The majority of patients have episodes of severe abdominal pain, nausea and vomiting that is caused by swelling in
the intestinal wall. Attacks that involve the face and throat must be taken seriously and medical treatment should be sought without delay. Swelling of the throat can close the air passage and cause death by suffocation. The mortality rate from
untreated airway obstruction has been reported to be over 40% with death most frequently caused by asphyxiation due to airway closure. The course of the disease is diverse and unpredictable, even within a single patient over his or her lifetime.
Swelling caused by HAE usually lasts for 24-72 hours, but the length of an attack can range from four hours to four days. On average, patients experience approximately one attack per month, but the frequency is highly variable. As many as 5% to 10%
of patients are severely affected, experiencing attacks one to three times per week. HAE affects between 1 in 10,000 and 1 in 50,000 individuals worldwide and there are believed to be as many as 11,000 people with HAE in the United States.

HAE is caused by a defective gene for C1 inhibitor (C1-INH), and this defect is passed on in families, such thata child has a 50%
chance of inheriting this disease if one parent is affected. The absence of family history, however, does not rule out HAE diagnosis, and as many as 20% of HAE cases involve patients who appear to have had a spontaneous mutation of the C1-INH gene.
This genetic defect results in the production of either inadequate levels or poorly functioning C1-INH protein.



2



---

##### Table of Contents

C1-INH is a normal constituent of human blood and primarily regulates activation of key inflammatory and
coagulation biochemical pathways, specifically the contact and complement pathways in addition to the fibrinolytic system. Regulation of these systems is performed through the formation of complexes between pathway proteinase enzyme and C1-INH,
resulting in inactivation of both and consumption of C1-INH. HAE patients have low levels of endogenous or functional C1-INH. Although the events that induce angioedema attacks in HAE patients are not well defined, it is thought that increased
blood vessel permeability leading to swelling and the clinical manifestations of HAE attacks are mediated primarily through contact system activation. Administration of Cinryze increases plasma levels of C1-INH activity. Increased
levels of functional C1-INH are thought to suppress contact system activation through the inactivation of plasma kallikrein and factor XIIa, preventing the generation of bradykinin, a natural peptide thought to be responsible for modulation of blood
vessel permeability.

Because HAE is rare and has a wide variability in disease expression, it is not uncommon for patients to remain
undiagnosed or misdiagnosed for many years. Many patients report that their frequent and severe abdominal pain was inappropriately diagnosed as psychosomatic. Although rare, HAE is a disease with potentially catastrophic consequences for those
affected. Aside from the potentially fatal acute respiratory compromise, unnecessary exploratory surgery has been performed on patients experiencing gastrointestinal edema because abdominal HAE attacks mimic conditions requiring surgery.

Traditionally, HAE has been classified into two types (I and II). The most common form of the disease, Type I, is characterized by low levels of C1-INH
and affects about 85% of patients, whereas Type II HAE affects 15% of patients and is characterized by poorly functioning C1-INH. A third type of HAE has been identified in which the abnormal C1-INH protein binds to albumin, effectively reducing the
amount of functional C1-INH.

Current Treatments of HAE

Treatment of HAE can be categorized as: (i) mitigation or acute treatments to remedy the symptoms of infrequent episodic acute attacks; and (ii) preventive or prophylactic treatments for
patients severely affected by HAE.

Current therapies primarily focus upon treating the symptoms of an acute attack. Two therapeutic agents
that can be used for treatment of acute attacks were approved by the FDA in 2009, a kallikrein inhibitor and a C1-INH. For swelling of the intestinal wall, which can cause debilitating pain, narcotics such as morphine and antiemetics for nausea are
often given. For severe laryngeal swelling, which can be life threatening, rescue therapy such as intubation or tracheotomy may be required. The use of fresh frozen plasma, which contains C1-INH but which also contains a wide variety of other
factors that may activate multiple inflammatory pathways and exacerbate an attack, is also used in some instances.

Cinryze is the only FDA
approved product for prevention of HAE attacks. Prior to the approval of Cinryze, patients who experience more than one attack per month have historically been treated with anabolic steroids that reduce the frequency of attacks of edema. The most
commonly used steroids are alpha-alkylated androgens. Use of such anabolic steroids can have numerous side effects ranging from hepatotoxicity (liver toxicity), virilization (development of male sexual characteristics in a female), weight gain, acne
and hirsutism (unwanted hair growth).

The FDA granted Cinryze seven years of marketing exclusivity for routine prophylaxis of HAE upon FDA
approval pursuant to the Orphan Drug Act. The Office of Orphan Products Development originally granted orphan drug designation for Cinryze on July 16, 2004. We are currently conducting a phase 4 study to evaluate the safety and effect of
escalating doses of Cinryze as prophylactic therapy which was a post approval requirement of the FDA.

Vancocin

In November 2004, we acquired all rights in the U.S. and its territories to manufacture, market and sell Vancocin, as well as rights to
certain related vancomycin products, from Eli Lilly and Company (Lilly). Lilly retained its rights to Vancocin outside of the U.S. and its territories. Vancocin is approved by the FDA for treatment of enterocolitis caused by S. aureus
(including methicillin-resistant strains) and antibiotic associated pseudomembranous colitis caused by C. difficile. Both are potentially serious infections of the gastrointestinal (GI) tract. S. aureus enterocolitis is rare;
accordingly, infection with C. difficileis the indication that accounts for the majority of Vancocins use.

CDI is an infection
of the GI tract. The clinical manifestations, ranging from diarrhea to toxicmegacolon and sometimes death, are a result of toxins produced by the bacterium that cause inflammation in the colon. Hospitalized patients, those residing in long-term care
centers, those greater than 65 years of age, and patients that have received broad-spectrum antibiotic therapy, are at greatest risk to acquire CDI.

CDI is not a nationally reportable disease and as such it is difficult to estimate the actual incidence of disease with precision. Based on reports from the Centers for Disease Control and Prevention
(CDC) and peer-reviewed publications, we estimate that at least 500,000 patients were affected by CDI in 2008. In recent years, many clinicians reported treating increasing numbers of patients with severe CDI and increased mortality rates.
Clinicians have also noted that some patients are progressing from mild/moderate disease to severe disease or death more rapidly than previously observed. The overall incidence of CDI may have plateaued or even decreased in 2009 relative to 2008,
however reliable data on current incidence are limited.



3



---

##### Table of Contents

Although the causes for this change in CDI remain under active investigation, the CDC has postulated that a
combination of changes in antibiotic use and infection control practices, along with the emergence of a hypervirulent strain of C. difficile, are likely contributors. As of late 2008, this strain (referred to as the toxinotype III, BI, or
NAP1/027 strain) has been identified in at least 40 states in the U.S.

Vancocin is the only drug approved by the FDA for the treatment of
antibiotic-associated pseudomembranous colitis caused by C. difficile. Historically metronidazole has been commonly used as first-line treatment for CDI, while Vancocin has been reserved for those patients who have failed metronidazole, have
recurrent disease, or who are suffering from severe CDI. We believe that changes in the epidemiology of CDI, in particular the increasing frequency of severe disease, and data suggesting that failure or relapse occur more commonly in patients
treated with metronidazole have led to an increase in the use of Vancocin.

In December 2008, FDA changed OGDs 2006 bioequivalence
recommendation, which we have opposed since its original proposal in March 2006, by issuing draft guidance for establishing bioequivalence to Vancocin which would require generic products that have the same inactive ingredients in the same
quantities as Vancocin (Q1 and Q2 the same) to demonstrate bioequivalence through comparative in vitro dissolution testing. Under this latest proposed method, any generic product that is not Q1 and Q2 the same as Vancocin would need
to conduct an in vivo study with clinical endpoints to demonstrate bioequivalence with Vancocin. On August 4, 2009 the FDAs Pharmaceutical Science and Clinical Pharmacology Advisory Committee voted in favor of the portion of the
OGDs 2008 draft guidelines on bioequivalence for Vancocin that restricts in vitro bioequivalence testing for generic products that are, among other things, Q1 and Q2 the same as Vancocin.

Product Pipeline

We currently have two development programs. Our C1 esterase inhibitor [human] related development program focuses on our efforts to commercialize Cinryze in Europe and certain other countries, conduct
clinical studies to identify additional therapeutic uses to expand the labeled indication for C1 esterase inhibitors to potentially include other C1 mediated diseases as well as new modes of administration of C1 esterase inhibitors. We are also
conducting Phase 1 clinical studies targeting the treatment and prevention of CDI utilizing the spore form of a non-toxin producing strain of C. difficile (NTCD). We continue to evaluate our maribavir program in light of the Phase 3 clinical trial
results.

In addition, we have licensed intranasal pleconaril to Merck who has assumed responsibility for all development and
commercialization of pleconaril in the U.S. and Canada.

HAE Program

Cinryze IV  EU and ROW

In January 2010, we obtained expanded rights to commercialize Cinryze in certain countries in Europe and ROW as well as rights to develop future C1-INH derived products for additional indications. We
intend to commercialize Cinryze in Europe when the product has received the EMA commission approval which we anticipate during 2011. HAE affects between 1 in 30,000 and 1 in 50,000 individuals in Europe. We are seeking approval to market Cinryze IV
to patients in Europe for the treatment and routine prophylaxis against attacks in adolescent and adult patients with HAE. Part of this commercialization plan was obtaining Orphan Drug designation for Europe which was granted in October 2009.

C1-INH concentrate has been marketed to HAE patients for acute treatment in Europe for 25 years. Our ability to compete in this marketplace
is contingent upon our success in differentiating Cinryze IV over existing CI-INH products.

We are currently in the early stages of
identifying the steps necessary to launch in territories outside of the US and EU.

Cinryze IV  Other C1 mediated
diseases and Cinryze  other formulations

We are currently evaluating with our partner Sanquin, the feasibility of additional
therapeutic uses and potential indications in addition to other formulations and modes of administration for Cinryze. We have conducted a Phase 1 study utilizing subcutaneous administration and expect to commence a Phase 2 study in 2010. We also
intend to conduct studies to identify further therapeutic uses and additional potential indications for other C1 mediated diseases. Our initial focus includes investigating C1-INH in transplant patients. Finally, we are currently evaluating a
recombinant C1-INH technology which may be incorporated in the treatment of C1 mediated diseases.



4



---

##### Table of Contents

CDI Program

NTCD

In February 2006, we announced that we had entered into a licensing agreement
with Dr. Dale Gerding, of the Hines VA, for the rights to develop non-toxigenic strains of C. difficile (NTCD) for the treatment and prevention of CDI. Under the license agreement, we are required to make royalty payments to Dr. Gerding
based on a low single digit percentage of our net sales of the product. If certain milestones are achieved, we will be obligated to pay Dr. Gerding additional milestone payments if and when certain regulatory developments are achieved, in an
aggregate amount equal to $850,000 in total, with no single milestone payment exceeding $250,000. The license agreement will remain in effect for ten years from the date any product is first commercialized, on a country-by-country basis, unless
earlier terminated. The agreement contains a standard early termination provision which provides for early termination by either party in the event certain conditions have occurred, including, but not limited to, either partys breach of the
agreement, either partys filing for bankruptcy or either party making an assignment for the benefit of its creditors. We plan to initially focus our efforts on the opportunity to prevent recurrence of CDI, using oral administration of spores
of non-toxin producing C. difficile. According to published literature, approximately 20 to 30 percent of patients suffering from CDI will have at least one episode of relapse of disease. The goal of our NTCD program is to prevent such recurrence of
disease. There is also the potential for NTCD to be used as primary prevention for CDI.

Over the past several years, CDI has increased in
severity and incidence. As such, the number of recurrent infections has also increased. According to a recent survey, 55 percent of participating US hospitals reported an increase in the number of treatment relapses over a recent 12 month
period. Because of this dramatic increase, finding new alternatives to prevent recurrent CDI remains an important medical goal. The underlying concept of this approach is to first treat the disease with an effective product like Vancocin
and eradicate the dangerous toxin-producing C. difficilewhich causes severe CDI. The treated patient could potentially then be dosed with oral NTCD to re-colonize the GI tract and prevent the pathogenic C. difficilebacteria from
re-infecting the colon until normal GI flora returns and the patient is no longer susceptible to disease.

In August 2009, dosing began in the
Phase 1 clinical trial for NTCD. The Phase 1 study will determine the safety and tolerability of NTCD dosed orally as single and repeat escalating doses in healthy young (18-45 years of age) and older (60 years of age and older) adults. The study is
being conducted in Switzerland. Should the therapy be well tolerated, we plan to initiate NTCD repeat dosing in older adults following exposure to oral antibiotics. Antibiotic use is associated with disruption of gastrointestinal flora which renders
individuals susceptible to C. difficilecolonization. The goal of NTCD dosing following antibiotic exposure is to colonize with this non-toxigenic strain of C. difficile and to prevent colonization by toxigenic strains, thereby
preventing disease. We expect the results of this Phase 1 clinical trial in the second half of 2010.

CMV Program

We continue to evaluate our maribavir program in light of the Phase 3 clinical trial results. On February 9, 2009, we announced that
our Phase 3 trial evaluating maribavir used as prophylaxis in allogeneic stem cell, or bone marrow, transplant (SCT) patients did not achieve its primary endpoint. In the primary analysis, there was no statistically significant difference between
maribavir and placebo in reducing the rate of CMV disease. In addition, the study failed to meet its key secondary endpoints. Maribavir was generally well tolerated in this clinical study.

On February 13, 2009, we announced that enrollment in our Phase 3 trial evaluating maribavir in liver transplant patients was discontinued and that all patients on study drug were moved to current
standard of care. This decision was made based on the results of the Phase 3 study of maribavir in stem cell transplant patients, and the recommendation from our independent Data Monitoring Committee who considered the rate of viremia in both arms
of the study. Subsequent to our announcements in February 2009, we have continued to wind down our two Phase 3 studies evaluating maribavir.

CMV is a member of the herpes virus group, which includes the viruses that cause chicken pox, mononucleosis, herpes labialis (cold sores) and genitalis
(genital herpes). Like other herpes viruses, CMV has the ability to remain dormant in the body for long periods of time. CMV infection rates average between 40% and 85% of adults in North America and Europe. In most individuals with intact immune
systems, CMV causes little to no apparent illness. However, in immunocompromised individuals, CMV can lead to serious disease or death. Currently, patients who are immunosuppressed following hematopoietic stem cell or solid organ transplantation
remain at high risk of CMV infection. In these patients, CMV can lead to severe conditions such as pneumonitis, gastroenteritis, or even death.

Business Development

We intend to continue to evaluate in-licensing or other
opportunities to acquire products in development, or those that are currently on the market. We plan to seek products that treat serious or life threatening illnesses with a high unmet medical need, require limited commercial infrastructure to
market, and that have the potential to provide both top and bottom line growth over time.

Competition for products currently in clinical
development, or that are currently on the market, is intense and may require significant resources. There is no assurance that we will be successful in acquiring such products, or that such products can be acquired on terms acceptable to us.
Additionally, if we are successful in acquiring a marketed product, we may have to expand our sales and marketing infrastructure both in the US and internationally. There is no assurance that we would be successful in expanding our commercial



5



---

##### Table of Contents

capabilities, that we would be able to penetrate the markets for any such products or that we could achieve market acceptance of our products. There are also no assurances that we will be able to
obtain financing for acquiring such products or to expanding our operations to realize the products potential.

In October 2008, we completed
our acquisition of Lev. Lev was a biopharmaceutical company focused on developing and commercializing therapeutic products for the treatment of inflammatory diseases. The terms of the merger agreement provided for the conversion of each share of Lev
common stock into upfront consideration in the aggregate amount of $453.1 million, or $2.75 per Lev share, comprised of $2.25 per share in cash and $0.50 per share in ViroPharma common stock, and contingent consideration (CVRs) of up to $1.00 per
share which may be paid upon the achievement of certain regulatory and commercial milestones.

As part of the merger consideration payable to
the former stockholders of Lev, we agreed to make up to two CVR payments upon the achievement of regulatory and commercial targets. As of December 31, 2009, only the second CVR as described below remains achievable. The target for the first CVR
payment of $0.50 per share (or $87.5 million) is no longer achievable and will not be paid as during the fourth quarter of 2009, a third partys human C1 inhibitor product was approved for the acute treatment of HAE and granted orphan
exclusivity. The second CVR payment of $0.50 per share ($87.5 million) becomes payable if Cinryze reaches at least $600 million in cumulative net product sales by October 2018.

Strategic Relationships

Cinryze and Sanquin

Pursuant to the terms of an existing Distribution and Manufacturing
Services Agreement between our subsidiary ViroPharma Biologics, Inc. (VP Biologics) with Stichting Sanquin Bloedvoorziening (Sanquin Blood Supply Foundation) (Sanquin) (the Original Sanquin Agreement), we held
(i) the exclusive right to distribute, market, offer for sale, sell, import and promote C1-INH derived from human plasma (including Cinryze) manufactured by Sanquin for the treatment of HAE in all countries in North America and South America
(other than the Dutch Overseas Territories, Argentina and Brazil) and Israel, and (ii) a right of first refusal to distribute, market, offer for sale, sell, import and promote C1-INH derived from human plasma manufactured by Sanquin for the
treatment of HAE in certain other geographic regions and under certain conditions.

On January 8, 2010 we obtained the exclusive rights
to research, develop, import, use, sell and offer for sale C1-INH derived products (other than Cetor) worldwide, other than the Excluded Territory (as defined below) for all potential indications pursuant to a Manufacturing and Distribution
Agreement (Europe and ROW) between our European subsidiary, ViroPharma SPRL (VP SPRL) and Sanquin (the ROW Agreement). The Excluded Territory includes (i) certain countries with existing distributors of Cinryze, Cetor
and Cetor NF namely France, Ireland, the United Kingdom, Egypt, Iran, Israel, Indonesia, Turkey, Argentina and Brazil (the Third Party Distributors) and (ii) countries in which Sanquin has historically operated namely, Belgium,
Finland, Luxemburg and The Netherlands (including the Dutch Overseas Territories) (the Precedent Countries and collectively, the Excluded Territory). In the event that any agreement with a Third Party Distributor in the
Excluded Territory is terminated, we have a right of first refusal to obtain the foregoing exclusive licenses to the C1-INH derived products with respect to such terminated country.

Also on January 8, 2010, we amended and restated the Original Sanquin Agreement (the Restated US Agreement). Pursuant to the terms of the Restated US Agreement, we retained the rights to
distribute, market, offer for sale, sell, import and promote C1-INH derived from human plasma (including Cinryze) manufactured by Sanquin for the treatment of HAE in all countries in North America and South America (other than the Dutch Overseas
Territories, Argentina and Brazil) and Israel.

The initial term of the Restated US Agreement ends on December 31, 2015. The term will
automatically renew for up to eighteen years (comprised of six three-year periods), unless the Restated US Agreement is earlier terminated by either party. Sanquin may terminate this Restated US Agreement by providing written notice to us at least
three years prior to the end of the initial term or any subsequent renewal period. We may terminate the Restated US Agreement by providing written notice to Sanquin at least two years prior to the end of the initial term or any subsequent renewal
period. Each party may terminate the Restated US Agreement upon written notice in the event of: (i) an uncured material breach of the other party or (ii) the other party is declared insolvent or bankrupt, a voluntary petition of bankruptcy
is filed by the other party, the other party makes or executes any assignment for the benefit of creditors or a receiver is appointed to control the business of the other party.

The initial term of the ROW Agreement will end on December 31, 2019, but shall automatically renew for up to eighteen years (comprised of six three-year periods), unless the ROW Agreement is earlier
terminated by either party. Sanquin may terminate the ROW Agreement by providing written notice to us at least three years prior to the end of the initial term or any subsequent renewal period. We may terminate the ROW Agreement by providing written
notice to Sanquin at least two years prior to the end of the initial term or any subsequent renewal period. Each party may terminate the ROW Agreement upon written notice to the other in the event of: (i) an uncured material breach of the other
party or (ii) in the event that other party (1) applies for or consents to an appointment of a receiver for itself or all or substantially all of its assets, (2) makes an assignment for the benefit of creditors, (3) commences a
voluntary case or bankruptcy or consents to any bankruptcy or restructuring relief or the appointment of or taking possession of its property in any such proceeding or (4) takes any corporate action to effect any of the foregoing.



6



---

##### Table of Contents

In January 2010, both parties established a Joint Steering Committee comprised of an equal number of
representatives from each of the parties to the agreements. The Joint Steering Committee shall serve as a forum to establish and discuss progress under, among others, (i) a global commercialization plan; (ii) clinical development programs
of ViroPharma and Sanquin early stage research programs; (iii) manufacturing capacity schedules; (iv) pharmacovigilence matters; (v) quality matters; (vi) manufacturing improvement programs; and (vii) regulatory matters.

Subject to certain terms of each of the Restated US Agreement and the ROW Agreement, if we do not use commercially reasonable efforts to file
applications for marketing authorization of Cinryze or launch Cinryze in accordance with a commercialization plan for the applicable territories, as approved by the Joint Steering Committee, Sanquin may (upon prior written notice to us) terminate
our rights in the applicable country.

In addition, pursuant to the terms of the ROW Agreement, Sanquin may conduct certain early stage
research programs (the Early Stage Research Programs), and we will provide to Sanquin 1,000,000 (approximately $1.4 million) per year for a period of five years to support such Early Stage Research Programs. We have a right of
first refusal to further develop and commercialize the subject matter of each such Early Stage Research Program worldwide (except for the Excluded Territory) subject to Sanquins and its research partners right to use any such
intellectual property for their internal, non-commercial research purposes. Except for the Early Stage Research Programs, we will be solely responsible for conducting all clinical trials and other development activities necessary to support our
efforts to obtain regulatory approval of Cinryze in additional territories as well as any future C1-INH derived products developed pursuant to the ROW Agreement. Sanquin has the right to approve any such clinical trials and development activities
through the Joint Steering Committee.

Sanquin may include in its regulatory dossiers improvements to Cinryze for the hereditary angioedema
(HAE) indication, solely for the marketing and sale of Cetor or Cetor NF in the Excluded Territory. If there are (i) new indications relating to any C1-INH product or (ii) improvements relating to the HAE-indication that cannot
be included in Sanquins regulatory dossiers, Sanquin will receive a royalty-free license to sell Cinryze or the future product for these new indications or improvements in the Precedent Countries.

Sanquin has agreed to indemnify us and our affiliates for certain losses, except to the extent we have an obligation to indemnify Sanquin. We have agreed
to indemnify Sanquin and its affiliates for all losses arising from (i) our infringement of any third partys intellectual property as a result of the sale of Cinryze or any future C1-INH derived products in the territories covered by the
agreements, (ii) a breach by us of the terms of the agreements, (iii) certain tax liabilities and (iv) our negligence or willful misconduct, except, in each case, to the extent Sanquin has an obligation to indemnify us.

Without Sanquins prior written consent, we shall not enter into a merger, be acquired by or sell substantially all of our assets to a manufacturer
and/or distributor of a plasma derived C1 esterase inhibitor or another plasma-derived product approved under applicable law for marketing for the same or comparable clinical indications as Cinryze or any future C1-INH derived products. We may not,
without the consent of Sanquin, distribute, market, offer for sale, sell, import or promote any competitive product in the territory covered by the Restated US Agreement until December 31, 2018. In addition, we may not, without the consent of
Sanquin, distribute, market, offer for sale, sell, import or promote any competitive product in the territories covered by the ROW Agreement until December 31, 2019.

In the event that VP Biologics has become bankrupt or insolvent and has committed an uncured breach of the Restated US Agreement, Sanquin will immediately obtain VP Biologics rights to the marketing
authorizations for Cinryze obtained by us and the applications for marketing authorization of Cinryze filed by us. ViroPharma Incorporated will guarantee VP Biologics performance under the Restated US Agreement. In the event that VP SPRL
becomes bankrupt or insolvent and commits an uncured breach of the ROW Agreement, Sanquin will immediately obtain our rights to the regulatory approvals for the products obtained by us under the ROW Agreement and the applications for regulatory
approval of the product filed by us under the ROW Agreement. ViroPharma Incorporated will guarantee VP SPRLs performance under the ROW Agreement in the event of a bankruptcy.

Vancocin Capsules and Lilly

In November 2004, we acquired all rights in the U.S. and its territories to manufacture, market and sell Vancocin, the oral capsule formulation of vancomycin hydrochloride, as well as rights to certain
related vancomycin products, from Lilly. Vancocin is a potent antibiotic approved by the FDA to treat antibiotic-associated pseudomembranous colitis caused by C. difficile and enterocolitis caused by S. aureus, including
methicillin-resistant strains. Lilly retained its rights to vancomycin outside of the U.S. and its territories.

We paid Lilly an upfront cash
payment of $116.0 million and we are obligated to pay additional purchase price consideration based on annual net sales of Vancocin through 2011. As of December 31, 2009, we have paid an aggregate of $37.1 million to Lilly in additional
purchase price consideration, as our net sales of Vancocin surpassed the maximum obligation level of $65 million in 2005 through 2009.



7



---

##### Table of Contents

For annual net sales during 2010 through 2011, we are obligated to pay additional amounts of 35% on net
sales between $45 and $65 million. No additional payments are due to Lilly on net sales of Vancocin below or above the net sales levels. We account for additional purchase price consideration as contingent consideration and record an adjustment to
the carrying amount of the related intangible assets and a cumulative adjustment to the intangible amortization upon achievement of the related sales milestones. See Note 6 of the Consolidated Financial Statements for additional information
regarding intangible assets and amortization.

In the event we develop any product line extensions, revive discontinued vancomycin product
lines (injectable or oral solutions), make improvements of existing products, or expand the label to cover new indications, Lilly would receive a royalty on net sales on these additional products for a predetermined time period.

Cytomegalovirus and GlaxoSmithKline

In August 2003, we entered into a license agreement with GlaxoSmithKline (GSK) under which we acquired worldwide rights (excluding Japan) to an antiviral compound, maribavir, for the treatment of CMV
disease. Maribavir is a benzimidazole compound that was in development by GSK for the treatment of CMV retinitis in HIV positive patients.

Under the terms of the agreement, we have exclusive worldwide rights (excluding Japan) to develop and commercialize maribavir for the prevention and
treatment of cytomegalovirus infections related to transplant (including solid organ and hematopoietic stem cell / bone marrow transplantation), congenital transmission, and in patients with HIV infection. The patents covering maribavir expire in
2015. We paid GSK a $3.5 million up-front cash licensing fee and will pay additional milestone payments based upon defined clinical development and regulatory events. In the third quarter of 2006, we recorded a $3.0 million milestone payment due to
GSK associated with the initiation of the phase 3 study of maribavir, which was paid in February 2007. No additional amounts were recorded in 2007. We also will pay royalties to GSK and its licensor on product sales in the U.S. and rest of world
(excluding Japan). We will be dependent on GSK to prosecute and maintain the patents related to maribavir, and to file any applications for patent term extension. We also may be dependent on GSK to protect such patent rights. We have the right to
sublicense our rights under the agreement, which under certain circumstances requires consent from GSK.

Picornaviruses and
Merck

In November 2004, we entered into a license agreement with Merck under which Merck has assumed responsibility for all future
development and commercialization of pleconaril in the U.S. and Canada. Merck paid us an upfront option fee of $3.0 million in November 2003. In August 2004, Merck exercised its option to enter into a full license agreement with us following its
assessment of the products performance in characterization studies. Merck paid us an initial license fee of $10.0 million in December 2004 and purchased our inventory of bulk drug substance for an additional $6.0 million in January 2005. We
are also eligible to receive up to an additional $65.0 million in milestone payments upon achievement of certain targeted regulatory and commercial events, as well as royalties on Mercks sales of intranasal pleconaril in the licensed
territories. Merck is now responsible for the development and commercialization of the intranasal formulation of pleconaril for the treatment of the common cold. Sanofi-Aventis has exclusive rights to market and sell pleconaril in countries other
than the U.S. and Canada.

Picornaviruses and Sanofi-Aventis

In our agreement with Sanofi-Aventis, originally entered into in December 1995 and amended and restated in February 2001, we received exclusive rights under patents owned by Sanofi-Aventis to develop and
market all products relating to pleconaril and related compounds for use in picornavirus disease indications in the U.S. and Canada, as well as a right of first refusal for any other indications in the U.S. and Canada. We further amended our
agreement with Sanofi-Aventis in November 2003 in connection with our entry into the option agreement with Merck in respect of intranasal pleconaril. As a result of Mercks August 2004 exercise of its option to continue the development and
commercialization of pleconaril, the November 2003 amendment provided that, amongst other things, the royalty rate payable to Sanofi-Aventis was reduced. Pleconaril is covered by one of the licensed U.S. patents, which expires in 2012, and one of
the licensed Canadian patents, which expires in 2013. We will be dependent on Sanofi-Aventis to prosecute and maintain certain of these patents, and to file any applications for patent term extension. We also may be dependent on Sanofi-Aventis to
protect such patent rights.

Under our agreement with Sanofi-Aventis, until the expiration or termination of the agreement, we must make
royalty payments on any sales of products in the U.S. and Canada developed under the agreement, which royalty payments will be reduced upon the expiration of the last patent on pleconaril or any related drug, except for reduced royalty payments on
Mercks sales of the drug, if any, which extends indefinitely. We are entitled to royalties from Sanofi-Aventis on sales of products by Sanofi-Aventis outside the U.S. and Canada. Sanofi-Aventis will make a milestone payment to us upon
submission of pleconaril for regulatory approval in Japan. We are required to pay a portion of these royalties and milestones payable to Merck under our agreement with them.

Our patent licenses under the amended and restated agreement with Sanofi-Aventis terminate on the later of expiration of the last patent licensed to us under the agreement or ten years following our first
sale of a product in the U.S. or Canada containing a compound licensed to us under the agreement, or earlier under certain circumstances. In the event that our rights to use Sanofi-Aventiss patents and trademarks terminate, under certain
circumstances the agreement may restrict our ability to market pleconaril and compete with Sanofi-Aventis. In addition, Sanofi-Aventis has the right to terminate the agreement if we are subject to a change of



8



---

##### Table of Contents

control that would materially and adversely affect the development, manufacturing and marketing of the products under the agreement. The term automatically renews for successive five-year terms
unless either party gives six months prior written notice of termination. We also have the right to manufacture, or contract with third parties to manufacture, any drug product derived from the pleconaril drug substance.

Manufacturing and Distribution

We currently utilize a virtual supply manufacturing and distribution chain in which we do not have our own facilities to manufacture commercial or clinical trial supplies of drugs and we do not have our
own distribution facilities. Additionally, we do not intend to develop such facilities for any product in the near future. Instead, we contract with third parties for the manufacture, warehousing, order management, billing and collection and
distribution of our products and product candidates. This virtual approach allows us the flexibility to adapt as our pipeline advances.

Cinryze

In conjunction with the Lev acquisition, we acquired a Distribution and
Manufacturing Services Agreement with Sanquin, which was amended and restated in January 2010 as described above. Additionally, in January 2010, we entered into the ROW Agreement as described above.

Restated U.S. Agreement

The terms of the Restated US Agreement related to manufacturing provide that Sanquin shall manufacture Cinryze for us on a toll manufacturing basis, using plasma supplied by us, for a manufacturing fee.
During the term, we shall purchase from Sanquin an annual minimum quantity of Cinryze established by the parties for such calendar year.

Sanquin is implementing structural and equipment changes to its Amsterdam and Brussels manufacturing facilities. We previously funded such changes to the
Brussels manufacturing facility and a portion of such changes to the Amsterdam manufacturing facility, each through a loan facility of an aggregate amount of 7,500,000 (approximately $10.4 million). Pursuant to the Restated US Agreement,
Sanquin will implement additional structural and equipment changes to the Brussels manufacturing facility, financed through an additional 5,000,000 (approximately $7.2 million) loan facility provided by us. Sanquin will repay all such loan
amounts by January 1, 2015 by providing us with a discount to the per unit purchase price of product.

Sanquin will use commercially
reasonable efforts to obtain regulatory approval to manufacture Cinryze in the Amsterdam manufacturing facility prior to a date agreed to by the parties. Sanquin will enter into manufacturing agreements with one or more third party manufacturers,
which may include affiliates of Sanquin, (reasonably acceptable to us) pursuant to which such third party manufacturers shall provide certain back-up manufacturing facilities for Cinryze. In the event that certain events occur which result in
Sanquin permanently ceasing to manufacture Cinryze, Sanquin will grant us a perpetual license under its intellectual property related to Cinryze and assign to us each of the agreements with such third party manufacturers. In consideration thereof,
we will pay a one-time fee to Sanquin as well as a royalty on future sales of Cinryze or any future C1-INH product.

ROW Agreement

The terms of the ROW Agreement related to manufacturing provide that Sanquin will manufacture Cinryze either based on a supply of plasma provided by Sanquin or on a toll-manufacturing basis using plasma
supplied by us for a manufacturing fee. The manufacturing fee will be comprised of a base fee and a royalty which shall vary based upon the source of the plasma utilized. The parties will negotiate in good faith a new purchase price and
manufacturing fee for any additional new products developed in accordance with the terms of the ROW Agreement. Beginning in 2015, we shall purchase at least a minimum quantity of Cinryze or future C1-INH product from Sanquin annually, which
quantities shall be determined by the Joint Steering Committee in 2013.

Sanquin will enter into manufacturing agreements with one or more
third party manufacturers, which may include affiliates of Sanquin, (reasonably acceptable to us) pursuant to which such third party manufacturers shall provide certain back-up manufacturing facilities for the products. In the event that certain
events occur which result in Sanquin permanently ceasing to manufacture Cinryze of future C1-INH derived products, Sanquin will grant us a perpetual license under its intellectual property related to Cinryze or any future C1-INH product and assign
to us each of the agreements with such third party manufacturers. In consideration thereof, we will pay a one-time fee to Sanquin as well as a royalty on future sales of Cinryze or any future C1-INH product.

Plasma

Cinryze is derived from human plasma sourced from commercial plasma suppliers. The sourcing of plasma, and the production of products derived from plasma,
is regulated extensively by the FDA and other medical product and health care regulatory agencies. We rely on a combination of sources for plasma including (i) long term supply agreements, (ii) periodic spot purchases of plasma
from third party plasma suppliers, and (iii) we are exploring options to acquire our own plasma centers.



9



---

##### Table of Contents

Supply Agreement with DCI Management Group, LLC

In connection with our acquisition of Lev, we became party to a supply agreement for the purchase and sale of plasma with DCI Management Group, LLC
pursuant to which we will purchase quantities of U.S. Source Plasma to be utilized in the production of product under our Distribution and Manufacturing Services Agreement with Sanquin Blood Supply Foundation. In July 2009 we amended the terms of
the agreement. Under the amended agreement, the supplier agreed to sell us specified annual quantities of plasma in accordance with applicable good manufacturing practices. Our annual purchase commitment is between $19.3 million and $25.4 million
for the balance of the term of the agreement. Our contractual purchase commitments are subject to annual percentage increases based on market conditions and do not include the cost of additional pre-delivery testing which we may require the supplier
to undertake. We estimate our remaining commitment under this agreement to be approximately $139.0 million.

The amended agreement expires
December 31, 2015, unless sooner terminated in accordance with its terms. Either party may terminate the agreement upon written notice if the other party is in material breach of any provision thereof, subject to applicable cure periods.
Subject to the suppliers ability to mitigate damages, in the event we are in default of our payment obligation under the contract, we will be liable to purchase the minimum quantities of plasma specified under the contract for the balance of
the term. Upon expiration of the agreement, or in the event the agreement is terminated for reasons other than as set forth above, we will be obligated to purchase a closing inventory of plasma in the quantity specified in the agreement.

Intermediate Supply Agreement with Biotest AG

On June 19, 2009, we entered into an intermediate supply agreement (the Supply Agreement) with Biotest AG (Biotest) pursuant to which we will sell to Biotest all excess output
of specific intermediate plasma products (the Intermediates) derived from the plasma processed by Sanquin in manufacturing Cinryze. In addition, we offered Biotest a right of first refusal to purchase unprocessed plasma in the event we
elect to sell unprocessed plasma to a third party. Biotest also agreed to provide us with a right of first refusal, subject to certain exceptions, to repurchase certain by products derived from the Intermediates. The Supply Agreement has an initial
term expiring December 31, 2014, unless sooner terminated. In addition we established pricing for a pre-determined volume of source plasma (the Target Volume), provided that the parties shall renegotiate pricing terms upon
achievement of the Target Volume. Either party may terminate the Supply Agreement upon written notice if the other party is in material breach of any provision thereof, subject to applicable cure periods. In the event of a breach of the Supply
Agreement by Biotest, Biotest shall be liable to purchase all amounts of Intermediates deliverable under the Supply Agreement during its remaining term.

Purchase Agreement with Plasma Centers of America, LLC

On April 3,
2008, we entered into a purchase agreement with Plasma Centers of America, LLC (PCA) pursuant to which we and PCA will, subject to the terms and conditions of the purchase agreement, consummate the following transactions: (1) construction of
three new plasma collection centers (New Centers) by PCA; (2); the acquisition by us of a maximum of the three new plasma collection centers, assuming the satisfaction of certain performance targets by PCA and (3) purchase by us of source
plasma from each of these new collection centers in accordance with the terms of the purchase agreement.

On October 20, 2009, we and PCA
entered into a letter agreement providing for the termination of the purchase agreement with PCA dated April 3, 2008. Pursuant to the Letter Agreement, the Purchase Agreement was immediately terminated and ViroPharma is no longer obligated to
perform its obligations under the Purchase Agreement. The Letter Agreement provides that PCA shall not be obligated to refund any payments previously made by ViroPharma to PCA, and also contains mutual releases between the parties. The parties
determined to mutually terminate the Purchase Agreement following disagreements regarding project timelines.

Vancocin

In December 2005 we entered into a toll manufacturing agreement with NPI Pharmaceuticals (formerly OSG Norwich Pharmaceuticals, Inc.) to
produce finished Vancocin product. The qualification process required to transfer Vancocin manufacturing from Lilly to NPI Pharmaceuticals was completed in February 2006. All approvals were finalized in the second quarter of 2006 and, since
June 30, 2006, all of our finished product has been supplied from NPI Pharmaceuticals. In April 2006, we also entered into an agreement with Alpharma, Inc. for the manufacturing of API for Vancocin. In October, 2007, we amended this agreement
with Alpharma to extend the agreement until December 2011 and identified an additional production facility that will produce API in the future. Prior to our agreement with NPI, we purchased Vancocin from Lilly from November 2004 until the second
quarter 2006.

We require in our manufacturing and processing agreements that all third-party contract manufacturers and processors produce
drug substance and product in accordance with the FDAs current Good Manufacturing Practices and all other applicable laws and regulations. We maintain confidentiality agreements with potential and existing manufacturers in order to protect our
proprietary rights related to our marketed drug and drug candidates.

We expect to continue to rely solely on our collaborators and
third-party manufacturers to manufacture drug substance and final drug products for both clinical development and commercial sale.



10



---

##### Table of Contents

Customers

We sell our products directly to wholesale drug distributors and specialty pharmacies/ specialty distributors who then distribute the product to pharmacies, hospitals, patients, physicians and long term
care facilities, among others. Net product sales to customers who accounted for 10% or more of our net product sales during the years ended December 31, 2009, 2008 and 2007 are as follows:



|           |  |                              |    |   |      |  |    |      |  |  |    |  
|---------- |  | ---------------------------- | -- | - | ---- |  | -- | ---- |  |  | -- | -
|           |  | Percentage of total revenues |   
|           |  | 2009                         |    |   | 2008 |  |    | 2007 | 
|Customer A |  |                              | 29 | % |      |  | 39 | %    |  |  | 37 | %
|Customer B |  |                              | 25 | % |      |  | 38 | %    |  |  | 40 | %
|Customer C |  |                              | 13 | % |      |  | 17 | %    |  |  | 16 | %
|Customer D |  |                              | 12 | % |      |  |   |      |  |  |   |  
|           |  |                              |    |   |      |  |    |      |  |  |    |  
|Total      |  |                              | 79 | % |      |  | 94 | %    |  |  | 93 | %
|           |  |                              |    |   |      |  |    |      |  |  |    |  

In 2009, four wholesalers represented 79% of our total net product sales. We do not believe that the loss of any one of
these wholesalers would have a material adverse effect on product sales because product sales would shift to other wholesalers or alternative forms of distribution. However, the loss of a wholesaler could increase our dependence on a reduced number
of wholesalers. We have entered into distribution service agreements with the parties identified in the table above.

Marketing and Sales

Our initial sales organization was established in 2008 in the Northeastern U.S. to target doctors and hospitals to promote Vancocin. With the commercial launch of Cinryze, we have transitioned our
existing sales force and expanded our sales force to target doctors who treat patients who have been diagnosed with HAE. Given the relatively limited HAE patient population, our U.S. sales force is small compared to other drugs with similar gross
revenues. Our sales force primarily focuses its efforts towards allergists, immunologists and home healthcare providers.

Foreign Operations

We conduct business in European countries through wholly-owned subsidiaries. Our international businesses are subject to risks customarily encountered in foreign operations, including fluctuations in
foreign currency exchange rates and controls, import and export controls and other economic, political and regulatory policies of local governments. We currently have operations in Belgium, the United Kingdom, France and Switzerland. In anticipation
of our commercial sales launch of Cinryze in Europe and certain other countries, we intend to expand our own commercial organizations in such territories and markets and sell Cinryze through our own sales force in these territories. This
infrastructure expansion will result in additional costs in future periods. Outside of the United States and European territories, we will evaluate sales efforts on a country-by-country basis, and it is possible that we will rely on relationships
with one or more companies with established distribution systems and direct sales forces in such countries.

Patents
and Proprietary Technology

We believe that patent protection and trade secret protection are important to our business and that
our future will depend, in part, on our ability to maintain our technology licenses, maintain trade secret protection, obtain patents and operate without infringing the proprietary rights of others both in the U.S. and abroad. The last core patent
protecting Vancocin expired in 1996. There are no core patents protecting Cinryze. In order to continue to obtain commercial benefits from Vancocin, we will rely on product manufacturing trade secrets, know-how and related non-patent intellectual
property, and regulatory barriers to competitive products. We own three pending U.S. patent applications covering vancomycin related technology. One issued U.S. patent and two pending U.S. patent applications describing compounds, compositions and
methods for treating respiratory syncytial virus (RSV) diseases have been transferred to another party. We have two issued U.S. patents and one pending U.S. patent application covering compounds, compositions and methods of treating and preventing
picarnovirus disease and one pending U.S. patent application covering methods of reducing rhinovirus contagion. We have three issued U.S. patents, six non-U.S. patents and four pending U.S. patent applications that we co-own with a single
development collaborator describing compounds and methods for treating hepatitis C and related virus diseases, including a patent application family that covers HCV-796 and claims related compounds, compositions and methods of use for the treatment
of HCV infections. We have one pending U.S. patent application covering benzimidazole related technology. We also have filed international, regional and non-U.S. national patent applications in order to pursue patent protection in major foreign
countries.



11



---

##### Table of Contents

As patent applications in the U.S. are maintained in secrecy until patents are issued (unless earlier
publication is required under applicable law or in connection with patents filed under the PCT) and as publication of discoveries in the scientific or patent literature often lags behind the actual discoveries, we cannot be certain that we or our
licensors were the first to make the inventions described in each of these pending patent applications or that we or our licensors were the first to file patent applications for such inventions. Furthermore, the patent positions of biotechnology and
pharmaceutical companies are highly uncertain and involve complex legal and factual questions, and, therefore, the breadth of claims allowed in biotechnology and pharmaceutical patents or their enforceability cannot be predicted. We cannot be sure
that any patents will issue from any of these patent applications or, should any patents issue, that we will be provided with adequate protection against potentially competitive products. Furthermore, we cannot be sure that should patents issue,
they will be of commercial value to us, or that private parties, including competitors, will not successfully challenge these patents or circumvent our patent position in the U.S. or abroad. In the absence of adequate patent protection, our business
may be adversely affected by competitors who develop comparable technology or products.

Pursuant to the terms of the Uruguay Round Agreements
Act, patents filed on or after June 8, 1995 have a term of twenty years from the date of filing, irrespective of the period of time it may take for the patent to ultimately issue. This may shorten the period of patent protection afforded to our
products as patent applications in the biopharmaceutical sector often take considerable time to issue. Under the Drug Price Competition and Patent Term Restoration Act of 1984, a sponsor may obtain marketing exclusivity for a period of time
following FDA approval of certain drug applications, regardless of patent status, if the drug is a new chemical entity or if new clinical studies were used to support the marketing application for the drug. Pursuant to the FDA Modernization Act of
1997, this period of exclusivity can be extended if the applicant performs certain studies in pediatric patients. This marketing exclusivity prevents a third party from obtaining FDA approval for a similar or identical drug under an Abbreviated New
Drug Application or a 505(b)(2) New Drug Application.

The Drug Price Competition and Patent Term Restoration Act of 1984 also
allows a patent owner to obtain an extension of applicable patent terms for a period equal to one-half the period of time elapsed between the filing of an Investigational New Drug Application, or IND, and the filing of the corresponding New Drug
Application, or NDA, plus the period of time between the filing of the NDA and FDA approval, with a five year maximum patent extension. We cannot be sure that we will be able to take advantage of either the patent term extension or marketing
exclusivity provisions of this law.

In order to protect the confidentiality of our technology, including trade secrets and know-how and other
proprietary technical and business information, we require all of our employees, consultants, advisors and collaborators to enter into confidentiality agreements that prohibit the use or disclosure of confidential information. The agreements also
oblige our employees, and to the extent practicable, our consultants, advisors and collaborators, to assign to us ideas, developments, discoveries and inventions made by such persons in connection with their work with us. We cannot be sure that
these agreements will maintain confidentiality, will prevent disclosure, or will protect our proprietary information or intellectual property, or that others will not independently develop substantially equivalent proprietary information or
intellectual property.

The pharmaceutical industry places considerable importance on obtaining patent and trade secret protection for new
technologies, products and processes. Our success depends, in part, on our ability to develop and maintain a strong patent position for our products and technologies in clinical development, both in the U.S. and in other countries. Litigation or
other legal proceedings may be necessary to defend against claims of infringement, to enforce our patents, or to protect our trade secrets, and could result in substantial cost to us and diversion of our efforts. We intend to file applications as
appropriate for patents describing the composition of matter of our drug candidates, the proprietary processes for producing such compositions, and the uses of our products and drug candidates.

Government Regulation

The FDA and comparable regulatory agencies in state and local jurisdictions and in foreign countries impose substantial requirements on the clinical development, licensure, manufacture, distribution and
marketing of pharmaceutical products. These agencies and other federal, state and local entities regulate research and development activities and the testing, manufacture, processing, quality control, safety, effectiveness, labeling, packaging,
storage, handling, distribution, record keeping, approval, advertising, marketing, and promotion of our products. All of our products will require FDA regulatory approval before commercialization. In particular, therapeutic products for human use
are subject to rigorous preclinical and clinical testing and other requirements of the Federal Food, Drug, and Cosmetic Act, implemented by the FDA, as well as similar statutory and regulatory requirements of foreign countries. Obtaining these
marketing approvals and subsequently complying with ongoing statutory and regulatory requirements is costly and time consuming. Any failure by us or our collaborators, licensors or licensees to obtain or maintain, or any delay in obtaining,
regulatory approval or in complying with other requirements, could adversely affect the commercialization of products then being developed by us and our ability to receive product or royalty revenues.



12



---

##### Table of Contents

The steps required before a new drug product may be distributed commercially in the U.S. generally include:



| |  |  | conducting appropriate preclinical laboratory evaluations of the products chemistry, formulation and stability, and animal studies to assess the
potential safety and efficacy of the product;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | submission to the FDA of an Investigational New Drug Application, including the results of preclinical evaluations and tests, along with manufacturing
information and analytical data plus any clinical data if the product previously was administered to humans including outside the US;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | obtaining approval of Institutional Review Boards, or IRBs, to introduce the drug into humans in clinical studies;
| | - |  | ------------------------------------------------------------------------------------------------------------------



| |  |  | conducting adequate and well-controlled human clinical trials that establish the safety and efficacy of the drug product candidate for the intended
use, typically in the following three sequential, or slightly overlapping stages:
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase 1: The drug is initially introduced into healthy human subjects or patients and tested for safety, dose tolerance, absorption, metabolism,
distribution, excretion and evidence of biological activity;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase 2: The drug is studied in controlled, exploratory therapeutic trials in a limited number of patients to identify possible adverse effects and
safety risks, to determine dose tolerance and the optimal effective dosage, and to collect initial efficacy data of the product for specific targeted diseases or medical conditions;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase 3: The drug is studied in an expanded, adequate, well-controlled patient population at multiple clinical study sites to demonstrate efficacy and
safety at the optimized dose by measuring a primary endpoint established at the outset of the study;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | submitting the results of basic research, including pharmacology and mechanisms of action animal studies, and clinical studies as well as chemistry,
manufacturing and controls information and patent certification information on the drug to the FDA in a NDA or BLA;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | undergoing a successful FDA pre-approval inspection prior to approval of an NDA or BLA; and
| | - |  | -------------------------------------------------------------------------------------------



| |  |  | obtaining FDA approval of the NDA or BLA prior to any commercial sale or shipment of the drug or biologic product.
| | - |  | ------------------------------------------------------------------------------------------------------------------

This process generally takes a number of years and typically requires substantial financial resources, and we cannot be certain that any approval will be
granted on a timely basis, if at all. The results of preclinical studies and initial clinical trials are not necessarily predictive of the results from large-scale clinical trials, and all clinical trials may be subject to additional costs, delays
or modifications due to a number of factors, including the difficulty in obtaining enough patients, clinical investigators, drug supply, or financial support, or because of unforeseen adverse effects or efficacy issues. In addition, an independent
IRB at each clinical site proposing to conduct the clinical trials must review and approve each study protocol and oversee the conduct of the trial. The FDA may also raise questions about the conduct of the trials as outlined in the IND and impose a
clinical hold on the trial. If a clinical hold is imposed, all of FDAs concerns must be resolved before the trial may begin again. Preclinical and clinical studies take several years to complete, and there is no guarantee that an IND we submit
will result in a submission of an NDA or BLA within any specific time period, if at all. Similar risks and uncertainties apply to the conduct and approval for licensure and marketing a product in non-U.S. markets around the world.

The FDA has issued regulations intended to expedite the approval process for the development, evaluation and marketing of new therapeutic products
intended to treat life-threatening or severely debilitating diseases, especially where no alternative therapies exist. If applicable, these provisions may streamline the traditional product development process in the U.S. Similarly, products that
represent a substantial improvement over existing therapies may be eligible for priority review and a FDA expedited review time of six months. Nonetheless, even if a product is eligible for these programs, or for priority review, approval may be
denied or delayed by the FDA or additional trials may be required. As a condition of approval FDA also can require further testing of the product and monitoring of the effect of commercialized products such as in a Risk Evaluation and Mitigation
Strategy (REMS) requirement, including restricted access to the product and potential registries in the US and to a greater extent in Europe, formalized requirements to access pediatric safety and effectiveness. The Agency has the power to prevent
or limit further marketing of a product based on the results of these post-approval commitments. Upon approval, a drug or biologic product may be marketed only in those dosage forms and for those indications approved in the NDA or BLA.

Any products manufactured or distributed by us pursuant to FDA approval are subject to extensive continuing post-approval regulation by the FDA,
including record-keeping requirements, obligations to investigate, analyze and report adverse experiences, and possible restrictions on advertising and promotional activities. In addition to continued compliance with standard regulatory
requirements, the FDA also may require post-marketing testing and surveillance to monitor the safety and efficacy of the marketed product. Results of post-marketing studies may limit or expand the further marketing of the products. If we propose any
modifications to a product, including changes in indication, manufacturing process, manufacturing facility or labeling, we may need to submit a



13



---

##### Table of Contents

NDA or BLA supplement to the FDA, and will not be able to commercialize any product with these modifications until FDA approval is received. Product approvals may be withdrawn if compliance with
regulatory requirements is not maintained or if problems concerning safety or efficacy of the product are discovered following approval.

Congress and regulatory authorities, including the FDA, are considering whether an abbreviated approval process for so-called generic or
follow-on biological products should be adopted. An abbreviated approval process is currently available under the Federal Food, Drug and Cosmetic Act for generic versions of conventional chemical drug compounds, sometimes referred to as
small molecule compounds, but not for biological products approved under the Public Health Service Act through a BLA. Currently, an applicant for a generic version of a small molecule compound only has to reference in its application an approved
product for which full clinical data demonstrating safety and effectiveness exist for the approved conditions of use; demonstrate that its product has the same active ingredients, dosage form, strength, route of administration and conditions of use
and is absorbed in the body at the same rate and to the same extent as the referenced approved drug; include certifications to non-infringement of valid patents listed with the FDA for the referenced approved drug; and await the expiration of any
non-patent exclusivity. Various proposals have been made to establish an abbreviated approval process to permit approval of generic or follow-on versions of biological products. It is unclear as to when, or if, any such proposals may be adopted but
any such abbreviated approval process could have a material impact on our business as follow-on products may be significantly less costly to bring to market and may be priced significantly lower than our products would be.

In addition to obtaining FDA approval for each indication to be treated with each product, each drug or biologic product manufacturing establishment must
register with the FDA, list its drug products with the FDA, comply with current Good Manufacturing Practices (cGMPs) and undergo periodic inspections by the FDA.

In complying with the FDAs cGMP regulations, manufacturers must continue to spend time, money and effort on facilities and equipment, process control, recordkeeping, personnel training, quality
control validation, and auditing to ensure that the marketed product meets applicable specifications and other requirements. The FDA periodically inspects drug or biologic product manufacturing facilities to ensure compliance with cGMPs. Failure to
comply with FDA requirements, including cGMPs, subjects the manufacturer to possible FDA enforcement action, such as untitled letters, Warning Letters, suspension of manufacturing operations, seizure of the product, voluntary or mandatory recall of
a product, injunctive action, consent decrees and/or suspension or revocation of product approval, as well as possible civil and criminal penalties. We currently rely on, and intend to continue to rely on, third parties to manufacture our compounds
and products. Such third parties will be required to comply with FDA requirements, including cGMPs. We cannot be certain that we, or our present or future suppliers or third-party manufacturers, will be able to comply with all FDA regulatory
requirements, and potential consequences of non-compliance could have a material adverse impact on our business.

Products manufactured in the
U.S. for distribution abroad will be subject to FDA regulations regarding export, as well as the requirements of the country to which they are shipped. These latter requirements are likely to cover the conduct of clinical trials, the submission of
marketing applications and all aspects of product manufacture and marketing. Such requirements can vary significantly from country to country. As part of possible strategic relationships, our collaborators may be responsible for the foreign
regulatory approval process of our products, although we may be legally liable for noncompliance. Foreign establishments manufacturing drug or biologic products for distribution in the U.S. also must register their establishments and list their
products with the FDA, and comply with cGMPs. They also are subject to periodic inspection by the FDA or by local authorities under agreement with the FDA.

The FDAs laws, regulations and policies may change, and additional governmental regulations or requirements may be enacted that could delay, limit or restrict, or prevent regulatory approval of our
products or affect our ability to test, manufacture, market, or distribute our products following approval.

On December 8, 2003, the
Medicare Prescription Drug, Improvement and Modernization Act (MMA) was signed into law and provides outpatient prescription drug coverage to eligible Medicare beneficiaries. The primary prescription drug benefit under the MMA, the new Medicare Part
D coverage, began in January 2006. The new Part D prescription drug benefit is administered regionally through Medicare-approved insurance plans. The legislation allows for the importation of prescription drugs from Canada, but only if the Secretary
of the U.S. Department of Health and Human Services certifies to Congress that such importation would pose no additional risk to the publics health and safety and would result in significant reduction in the cost to customers, which the
Secretary thus far has not done. There can be no assurance that this certification requirement will be maintained in future legislation or that the certification will continue to be withheld. The impact could also be negative over the intermediate
and longer term for our business generally as greater federal involvement and budget constraints may increase the likelihood of additional pricing pressures or controls in the future.

Federal and state governments also have pursued direct methods to reduce the cost of drugs for which they pay. We participate in state government-managed Medicaid programs as well as certain other
qualifying federal and state government programs whereby discounts and mandatory rebates are provided to participating state and local government entities. We also participate in other programs with government entities, the most significant of which
are the U.S. Department of Defense and the U.S. Department of Veterans Affairs. These entities receive minimum discounts based off a defined non-federal average manufacturer price for



14



---

##### Table of Contents

purchases. Additional programs in which we participate provide mandatory discounts for outpatient medicines purchased by certain Public Health Service entities and disproportionate
share hospitals (hospitals meeting certain criteria regarding the percentage of needy population served).

Our operations are also
subject to federal and state anti-kickback laws. Certain provisions of the Social Security Act prohibit entities such as us from knowingly and willingly offering, paying, soliciting or receiving any form of remuneration (including any kickbacks,
bribe or rebate) in return for the referral of items or services for which payment may be made under a federal health care program, or in return for the recommendation, arrangement, purchase, lease or order of items or services for which payment may
be made under a federal health care program. Violation of the federal anti-kickback law is a felony, punishable by criminal fines and imprisonment for up to five years or both. In addition, the Department of Health and Human Services may impose
civil penalties and exclude violators from participation in federal health care programs such as Medicare and Medicaid. Many states have adopted similar prohibitions against payments intended to induce referrals of products or services paid by
Medicaid or other third party payors. Several states have also enacted laws requiring recordkeeping, compliance requirements, and reporting of gifts and other value given to healthcare providers. Because of the far-reaching nature of these laws,
there can be no assurance that the occurrence of one or more violations of these laws would not result in a material adverse effect on our business, financial condition and results of operations.

We are also subject to various other federal, state and local laws, rules, regulations and policies relating to safe working conditions, clinical,
laboratory and manufacturing practices, environmental protection, the experimental use of animals and the use and disposal of hazardous or potentially hazardous substances, including radioactive compounds and infectious disease agents, previously
used in connection with our research work. Although we believe that our safety procedures for handling and disposing of such materials comply with current federal, state and local laws, rules, regulations and policies, the risk of accidental injury
or contamination from these materials cannot be entirely eliminated. We may also incur significant costs to comply with such laws and regulations now and in the future, and the failure to comply may have a material adverse impact on our business.

Moreover, we anticipate that Congress, state legislatures and the private sector will continue to review and assess controls on health care
spending. Any such proposed or actual changes could cause us or our collaborators to limit or eliminate spending on development projects and may otherwise affect us. We cannot predict the likelihood, nature, or extent of adverse governmental
regulation that might result from future legislative or administrative action, either in the U.S. or abroad. Additionally, in both domestic and foreign markets, sales of our proposed products will depend, in part, upon the availability of
reimbursement from third-party payors, such as government health administration authorities, managed care providers, private health insurers and other organizations. Significant uncertainty often exists as to the reimbursement status of newly
approved health care products. In addition, third-party payors are increasingly challenging the price and cost effectiveness of medical products and services. There can be no assurance that our proposed products will be considered cost-effective or
that adequate third-party reimbursement will be available to enable us to maintain price levels sufficient to realize an appropriate return on our investment in product research and development.

In the United States, the Orphan Drug Act provides incentives to drug manufacturers to develop and manufacture drugs for the treatment of rare diseases,
currently defined as diseases that affect fewer than 200,000 individuals in the United States, or for a disease that affects more than 200,000 individuals in the United States, where the sponsor does not realistically anticipate its product becoming
profitable. The FDA has granted Cinryze seven years of marketing exclusivity to Cinryze (C1 esterase inhibitor [human]) for routine prophylaxis in adolescent and adult patients with hereditary angioedema (HAE) pursuant to the Orphan Drug Act. Lev
originally received orphan drug designation for Cinryze by the Office of Orphan Products Development on July 16, 2004. Additionally, the FDA has granted maribavir orphan drug status for prevention of cytomegalovirus (CMV) viremia and disease in
the populations at-risk. Under the Orphan Drug Act, a manufacturer of a designated orphan product can seek certain tax benefits, and the holder of the first FDA approval of a designated orphan product will be granted a seven-year period of marketing
exclusivity for that product for the orphan indication. While the marketing exclusivity of an orphan drug would prevent other sponsors from obtaining approval of the same drug compound for the same indication unless the subsequent sponsors could
demonstrate clinical superiority or a market shortage occurs, it would not prevent other sponsors from obtaining approval of the same compound for other indications or the use of other types of drugs for the same use as the orphan drug. The U.S.
Congress has considered, and may consider in the future, legislation that would restrict the duration or scope of the market exclusivity of an orphan drug and, thus, we cannot be sure that the benefits of the existing statute will remain in effect.
Additionally, we cannot be sure that other governmental regulations applicable to our products will not change. We rely on the marketing exclusivity provided by the Orphan Drug Act for Cinryze as there are no core patents protecting Cinryze.

Foreign Regulation

In addition to regulations in the United States, we are subject to a variety of foreign regulatory requirements governing human clinical trials and marketing approval for drugs. The foreign regulatory
approval process includes all of the risks associated with FDA approval set forth above, as well as additional country-specific regulations. Whether or not we obtain FDA approval for a product, we must obtain approval of a product by the comparable
regulatory authorities of foreign countries before we can commence clinical trials or marketing of the product in those countries. The approval process varies from country to country, and the time may be longer or shorter than that required for FDA
approval. The requirements governing the conduct of clinical trials, product licensing, pricing and reimbursement vary greatly from country to country.



15



---

##### Table of Contents

For example, under European Union regulatory systems, we may submit marketing authorizations either under a
centralized or decentralized procedure. The centralized procedure provides for the grant of a single marketing authorization that is valid for all European Union member states. The decentralized procedure provides for mutual recognition of national
approval decisions, and the holder of a national marketing authorization may submit an application to the remaining member states. We submitted our Marketing Authorization Application for Cinryze for the acute treatment and prophylaxis of HAE to the
European Medicines Agency (EMA), using the centralized procedure.

Before submitting a Marketing Authorization Application (MAA) in the EU, a
company must obtain approval of a Paediatric Investigation Plan (PIP) from the EMAs Paediatric Committee (PDCO). The PIP describes the pediatric development of a product and may include pharmaceutical development, non-clinical and clinical
activities. The PIP will also define the age ranges of the children for whom the product must be developed and the timelines that the sponsor must meet, including, for example, the deferral of some studies. The PIP is updated as new information is
obtained. The incentives for completing the PIP include 6 months patent extension and, for orphan medicinal products, an additional 2 years orphan exclusivity. In October 2009 and March 2009 PIPs were approved for Cinryze and maribavir,
respectively.

Legislation similar to the Orphan Drug Act has been enacted in other countries outside of the United States, including the
European Union. The orphan legislation in the European Union is available for therapies addressing conditions that affect five or fewer out of 10,000 persons. The market exclusivity period is for ten years, although that period can be reduced to six
years if, at the end of the fifth year, available evidence establishes that the product is sufficiently profitable not to justify maintenance of market exclusivity. In October 2009 and December 2007, the Company was granted orphan medical
product designation for Cinryze and maribavir, respectively, by the Committee for Orphan Medicinal Products of the EMA.

In some foreign
countries, the proposed pricing for a drug must be approved before it may be lawfully marketed. The requirements governing drug pricing vary widely from country to country. For example, the European Union provides options for its member states to
restrict the range of medicinal products for which their national health insurance systems provide reimbursement and to control the prices and/or reimbursement of medicinal products for human use. A member state may approve a specific price or level
of reimbursement for the medicinal product, or it may instead adopt a system of direct or indirect controls on the profitability of the company placing the medicinal product on the market. In the event we receive regulatory approval of Cinryze in
the EU, we will need to engage with appropriate authorities on the operational, reimbursement, price approval and funding processes that are separately required in each country.

Competition

Other companies are developing treatments for the disease states for which we market products or are developing product candidates, including compounds in
preclinical and clinical development for HAE, C. difficile, and CMV. These companies include both public and private entities, including well-known, large pharmaceutical companies, chemical companies, biotechnology companies and research
institutions. Our ability to compete successfully will be based on our ability to:



| |  |  | develop proprietary products;
| | - |  | -----------------------------



| |  |  | attract and retain scientific personnel;
| | - |  | ----------------------------------------



| |  |  | obtain patent or other protection for our products;
| | - |  | ---------------------------------------------------



| |  |  | obtain required regulatory approvals; and
| | - |  | -----------------------------------------



| |  |  | manufacture and successfully market our products either alone or through outside parties.
| | - |  | -----------------------------------------------------------------------------------------

HAE

We do not have patent protection for the composition of Cinryze and we rely on the exclusivity provided by the Orphan Drug Act. The
FDA granted Cinryze seven years of marketing exclusivity to Cinryze C1 inhibitor (human) for routine prophylaxis of HAE pursuant to the Orphan Drug Act. Steroid based products are currently used for prophylaxis of HAE. In the fourth quarter of 2009
the FDA has granted marketing approval of CSL Behrings product, Berinert® C1-Esterase Inhibitor, Human,
for the treatment of acute abdominal or facial attacks of hereditary angioedema and Berinert has received exclusivity pursuant to the Orphan Drug Act. This approval will prevent us from obtaining FDA licensure and marketing our C1-INH product for
the treatment of acute abdominal or facial attacks HAE for up to seven years. Additionally, in the fourth quarter of 2009, Dyax received approval for their product candidate for the acute treatment of HAE. In addition, Pharming NV and Shire are
currently developing products for the acute treatment of HAE.



16



---

##### Table of Contents

CDI

The last core patent protecting Vancocin expired in 1996. As a result, there is a potential for significant competition from generic versions of Vancocin. Such competition would result in a significant
reduction in sales of Vancocin. We believe that regulatory hurdles (notwithstanding the recent actions taken by the OGD, described below), as well as product manufacturing trade secrets, know-how and related non-patent intellectual property may
impact market entry of generic competition. However, there can be no assurance that these barriers will actually impact generic competition.

In December 2008, FDA changed OGDs 2006 bioequivalence recommendation, which we have opposed since its original proposal in March 2006, by issuing
draft guidance for establishing bioequivalence to Vancocin which would require generic products that have the same inactive ingredients in the same quantities as Vancocin (Q1 and Q2 the same) to demonstrate bioequivalence through
comparative in vitro dissolution testing. Under this latest proposed method, any generic product that is not Q1 and Q2 the same as Vancocin would need to conduct an in vivo study with clinical endpoints to demonstrate bioequivalence with
Vancocin.

On August 4, 2009 the FDAs Pharmaceutical Science and Clinical Pharmacology Advisory Committee voted in favor of the
OGDs 2008 draft guidelines on bioequivalence for Vancocin. If FDAs proposed bioequivalence method for Vancocin becomes effective, the time period in which a generic competitor could be approved would be reduced and multiple generics may
enter the market, which would materially impact our operating results, cash flows and possibly intangible asset valuations. This could also result in a reduction to the useful life of the Vancocin-related intangible assets. Management currently
believes there are no indicators that would require a change in useful life as management believes that Vancocin will continue to be utilized along with generics that may enter the market, and the number of generics and the timing of their market
entry is unknown.

Additionally, Optimer Pharmaceuticals, Salix Pharmaceutical and Cubist Pharmaceuticals have clinical development programs
with therapeutic agents for the treatment of C. difficileinfection that could be found to have competitive advantages over Vancocin. Approval of new products, or expanded use of currently available products, to treat CDI, and particularly
severe disease caused by C. difficile infection, could materially and adversely affect our sales of Vancocin. Vancocin sales for treatment of antibiotic-associated pseudomembranous colitis caused by C. difficile have decreased over the
past 12 months and Vancocins share of the U.S. market for this indication may continue to decrease due to competitive forces and market dynamics. Metronidazole, a generic product, is regularly prescribed to treat CDI at costs which are
substantially lower than for Vancocin. In addition, products which are currently marketed for other indications by other companies may also be prescribed to treat this indication.

CMV

Stem cell and solid
organ transplant patients at risk for CMV infection or with active CMV disease are most likely to receive ganciclovir or valganciclovir (prodrug of ganciclovir), each of which were developed and are marketed by F. Hoffmann-La Roche. Ganciclovir and
valganciclovir are associated with the adverse effect of neutropenia, which may limit their use in certain patients. Foscarnet (AstraZeneca) and cidofvir (Gilead Sciences) may also be used to treat active CMV infections in certain patient
populations such as neutropenic patients, patients with ganciclovir-resistant CMV infection, or patients for whom ganciclovir is otherwise contraindicated. However, use of either foscarnet or cidofovir is limited by the side effect of renal
toxicity. Other broad-spectrum antiviral agents including valacyclovir and acyclovir (GSK) are marketed in several countries, and may also be used for the prevention of CMV infection in some patients. We believe that there are a number of vaccine
product in clinical trials for the prevention of CMV infection and other companies may have research and development programs with molecules active against CMV.

Business Development

We intend to continue to evaluate in-licensing or other opportunities
to acquire products in development, or those that are currently on the market. We plan to seek products that treat serious or life threatening illnesses with a high unmet medical need, require limited commercial infrastructure to market, and that
provide both top and bottom line growth over time.

Many of our competitors have substantially greater financial, research and development,
manufacturing, marketing and human resources than we do.

Employees

As of February 19, 2010, we had 188 employees of which 169 were employed in the United States and 19 were located in Europe. A significant number of
our management and professional employees have had prior experience with pharmaceutical, biotechnology or medical products companies. None of our employees are covered by collective bargaining agreements. We believe that we have been successful in
attracting skilled and experienced personnel; however, competition for such personnel is intense. We believe that our relations with our employees are good.



17



---

##### Table of Contents

Executive Officers



|                        |  |     |  |                                                                          
|----------------------- |  | --- |  | -------------------------------------------------------------------------
|Name                    |  | Age |  | Position                                                                 
|Vincent J. Milano       |  | 46  |  | President, Chief Executive Officer and Chairman of the Board of Directors
|Charles A. Rowland, Jr. |  | 51  |  | Vice President, Chief Financial Officer                                  
|Colin Broom, M.D.       |  | 54  |  | Vice President, Chief Scientific Officer                                 
|Thomas F. Doyle         |  | 49  |  | Vice President, Strategic Initiatives                                    
|Daniel B. Soland        |  | 51  |  | Vice President, Chief Operating Officer                                  
|Robert G. Pietrusko     |  | 61  |  | Vice President, Regulatory Affairs and Quality                           
|J. Peter Wolf           |  | 40  |  | Vice President, General Counsel and Secretary                            
|Richard S. Morris       |  | 36  |  | Controller and Chief Accounting Officer                                  

Vincent J. Milano
joined the company in 1996, and has served as President and Chief Executive Officer since March 31, 2008. He became Chairman of the Board of Directors in December 2008. He served as our Chief Operating Officer from January 2006 to March 2008
and as Vice President, Chief Financial Officer of ViroPharma from November 1997 to March 2008. Mr. Milano has also previously served as our Vice President, Finance & Administration, as Treasurer, and as Executive Director,
Finance & Administration. Prior to joining ViroPharma, Mr. Milano was with KPMG LLP, independent certified public accountants, where he was a Senior Manager. Mr. Milano served on the board of directors of Verticalnet, Inc. from
August 2003 until the company was acquired by BravoSolution S.p.A. in January 2008. Mr. Milano received his Bachelor of Science degree in Accounting from Rider College.

Charles A. Rowland, Jr. has served as our Vice President, Chief Financial Officer since he joined the company in October 2008. Prior to joining ViroPharma, Mr. Rowland served as Executive Vice
President, Chief Financial Officer of Endo Pharmaceuticals from December 2006 to September 2008. Prior thereto, Mr. Rowland was Senior Vice President and CFO of Biovail Pharmaceuticals, Inc. from 2004 to 2006. From 2001 to 2004, he was Chief
Operating and Financial Officer for Breakaway Technologies, a management consulting company. His pharmaceutical industry career includes positions of increasing scope and responsibility at Pharmacia Corp., where he had global responsibility for
Finance and Information Technology for the Pharmaceutical Business and financial responsibility for the Global Supply organization as Vice President, Finance Global Supply and VP Finance & IT-Global Pharma Ops; Novartis Pharmaceuticals
Corp., where he was Vice President, Planning and Decision Support, and Bristol-Myers Squibb, where he served as Director of Finance. Mr. Rowland received his Bachelor of Science degree in Accounting from St. Josephs University and a MBA
from Rutgers University.

Colin Broom, M.D. has served as Vice President, Chief Scientific Officer of ViroPharma since May 2004. From 2000
until 2003, Dr. Broom served as Vice President of Clinical Development and Medical Affairs, Europe, for Amgen. From 1998 to 1999, Dr. Broom served as Senior Vice President of Global Clinical Development for Hoechst Marion Roussel, now
Sanofi-Aventis. From 1984 until 1998, Dr. Broom was with Glaxo and then SmithKline Beecham, where he held positions of increasing seniority in clinical pharmacology in Europe before moving to the U.S. to head global oncology and subsequently
becoming Vice President of CNS/GI. Dr. Broom holds a Bachelor of Science degree in Pharmacology from University College London, and a Bachelor of Medicine and Bachelor of Surgery degree from St. Georges Hospital Medical School.
Dr. Broom is a Member of the Royal College of Physicians and a Fellow of the Faculty of Pharmaceutical Medicine of the UK Colleges of Physicians. Dr. Broom has been a director of NPS Pharmaceuticals since July 2009.

Thomas F. Doyle is Vice President, Strategic Initiatives as of January 2008. Mr. Doyle previously served as Vice President, General Counsel of
ViroPharma from November 1997 to January 2008, as Secretary from February 1997 to January 2008 and as Executive Director, Counsel since joining ViroPharma in November 1996 to February 1997. From 1990 until 1996, Mr. Doyle was a corporate
attorney with the law firm of Pepper Hamilton LLP. Mr. Doyle received his J.D. from Temple University School of Law. Prior to attending Temple University, Mr. Doyle was a Certified Public Accountant. Mr. Doyle received his Bachelor of
Science degree in Accounting from Mt. St. Marys College.

Daniel B. Soland joined ViroPharma in November 2006 as our Vice President,
Chief Commercial Officer and has served as our Chief Operating Officer since March 2008.From February 2005 until June 2006, Mr. Soland served as President of Chiron Vaccines. From March 2003 until February 2005, Mr. Soland was
President and Chief Executive Officer at Epigenesis Pharmaceuticals, a privately held biopharmaceutical company. Prior to that, Mr. Soland spent nine years with GlaxoSmithKline as the Vice President and Director of Worldwide Marketing
Operations, and five years as GSKs Vice President and Director of the U.S. Vaccines Business Unit. Mr. Soland holds a Bachelor of Science degree in Pharmacy from the University of Iowa, in Iowa City, IA.

Robert G. Pietrusko, Phrm.D., has served as Vice President, Global Regulatory Affairs and Quality since joining ViroPharma in 2007. Prior to joining
ViroPharma, Dr. Pietrusko served as Senior Vice President of Worldwide Regulatory Affairs for Millennium Pharmaceuticals, Inc. from 2001 through May 2007. Dr. Pietrusko spent 19 years at GlaxoSmithKline, culminating in his tenure as Vice
President and Director, Anti-infective and Antiviral Therapeutic Areas, U.S. Regulatory Affairs Dr. Pietrusko holds a Bachelor of Science degree in Biology and a Bachelors of Pharmacy degree from Rutgers University, and a Doctor of Pharmacy
degree from the Philadelphia College of Pharmacy and Science.



18



---

##### Table of Contents

J. Peter Wolf has served as Vice President, General Counsel, and Secretary since January 1, 2008.
Mr. Wolf previously served as Associate General Counsel of ViroPharma since 2004. From 2000 to 2004 Mr. Wolf was a corporate attorney with the law firm of Pepper Hamilton LLP and as an associate at two other private law firms.
Mr. Wolf received his J.D. from the George Washington University National Law Center and his Bachelor of Arts from the University of Delaware.

Richard S. Morris, CPA has served as Chief Accounting Officer of ViroPharma since April 2008. From December 2001 until April 2008, Mr. Morris has served in increasing levels of
responsibility at ViroPharma, most recently as Controller from January of 2005 through April 2008. Prior to joining ViroPharma, Mr. Morris worked for KPMG LLP in their Healthcare Assurance practice. Mr. Morris holds a bachelors
degree in Accounting from Saint Josephs University and has been a CPA since 1999.

Available Information

Our Internet website is www.viropharma.com and you may find our SEC filings on the Investors tab of that website. We provide access to all of
our filings with the SEC, free of charge, as soon as reasonably practicable after filing with the SEC on such site. Our Internet website and the information contained on that website, or accessible from our website, is not intended to be
incorporated into this Annual Report on Form 10-K or any other filings we make with the SEC.



19



---

##### Table of Contents

PART III



|ITEM 11. | EXECUTIVE COMPENSATION
|-------- | ----------------------

Compensation Discussion and Analysis

Executive Summary

In this Compensation Discussion and Analysis, we
address the compensation provided to our named executive officers listed below under Our Named Executive Officers and in the Summary Compensation Table that follows this discussion, the goals that we seek to achieve through our executive
compensation program and other important factors underlying our compensation practices and policies.

For 2009, our
compensation committee structured our compensation program in a manner designed to help us achieve our business objectives and provide compensation that is appropriate and fair in light of our strong financial performance relative to that of our
peer group and overall economic conditions.

2009 was our first full year in the commercial launch of
Cinryze for routine prophylaxis of hereditary angioedema (HAE). The launch was very successful as we reached over 400 patients and achieved net product sales of $97.3 million. When combined with $213.1 million in net product sales of Vancocin, we
achieved total revenues of $310.4 million. In connection with the launch of Cinryze for routine prophylaxis of HAE, we developed and successfully launched a Cinryze patient access program, CinryzeSolutionsTMand a new sales team for Cinryze. We also continued to strengthen
our balance sheet as we ended 2009 with over $400 million in working capital, including cash and cash equivalents in excess of $330 million. Our financial results allow us to continue our efforts to find new therapies for unmet medical needs, both
through internal development and external business development activities. During 2009, we advanced our clinical non-toxigenic clostridium difficile(NTCD) program by commencing a phase 1 study to determine the safety and tolerability of NTCD
dosed orally as a single and repeat escalating doses in healthy young and older adults. Unfortunately, we suffered a setback in our clinical program with maribavir as prophylaxis against CMV disease in transplant patients. On February 9, 2009,
we announced that our Phase 3 trial evaluating maribavir used as prophylaxis in allogeneic stem cell, or bone marrow, transplant patients did not achieve its primary endpoint. As a result, we also discontinued enrollment in our Phase 3 trial
evaluating maribavir in liver transplant patients. We continue to evaluate our maribavir program in light of the Phase 3 clinical trial results. Additionally, in January 2010, we secured rights to develop, file regulatory dossiers, and commercialize
Cinryze for HAE as well as potential new indications in certain European and rest of world countries.

Objectives of
Compensation

Our primary objectives with respect to executive compensation are to provide compensation designed to
attract, motivate and retain executives of outstanding ability and potential, tie annual and long-term cash and stock incentives to achievement of measurable company and individual performance objectives and align the interests of executive officers
with the interests of our stockholders. We seek to avoid compensation arrangements that would encourage our executives to take excessive risk in their business decisions. Our executive compensation program rewards executives who demonstrate the
ability to lead our business as evidenced by strong financial results and operational achievement. Our executive compensation program is designed to be transparent to ensure that executives and other stakeholders understand the program and its
objectives. To that end, we focus on providing incentives for superior individual performance by paying competitive compensation, and base a significant portion of compensation upon the companys and the employees performance. We believe
that our stockholders are best served when we can attract and retain talented executives by providing compensation packages that are competitive.

To that end, we believe our approach to goal setting, setting of targets with payouts at multiple levels of performance, and evaluation of performance results assist in mitigating excessive risk-taking
that could harm our value or reward poor judgment by our executives. Several features of our programs reflect sound risk management practices. We believe we have allocated our compensation among base salary and short and long-term compensation
target opportunities in such a way as to not encourage excessive risk-taking. This is based on our belief that applying company wide metrics encourages decision making that is in the best long-term interests of the company and our stockholders.



20



---

##### Table of Contents

Process

Our compensation committee is responsible for determining the compensation of our named executive officers included in the Summary
Compensation Table on page 33. For purposes of determining compensation for our named executive officers other than our chief executive officer, our compensation committee takes into account the recommendation of our chief executive officer.
The compensation committee is primarily responsible for overseeing our incentive compensation plans and equity-based plans, under which stock option grants have been made to employees, including the named executive officers, as well as non-employee
directors.

The compensation committee consists of two non-employee directors, each of whom is independent under
applicable NASDAQ rules, a Non-Employee Director as defined in Rule 16b-3 under the Securities Exchange Act of 1934, as amended, and an Outside Director as defined under the treasury regulations promulgated under
Section 162(m) of the Internal Revenue Code. The Report of the Compensation Committee is set forth on page 32 of this proxy statement.

Role of Consultants

To assist the compensation committee in carrying out
its responsibilities, in 2009, we engaged Mercer (US) Inc. (Mercer) to conduct an annual review of our total compensation program for our named executive officers as well as for certain other key executives. Mercer worked with both the compensation
committee and management to provide information and guidance regarding emerging market practices, trends and changes in regulatory environment and an outside point of view regarding compensation proposals. Our consultant provided market pay data
from both published salary surveys as well as data from SEC filings of a group of industry peers. The compensation committee has a policy of periodically engaging a different compensation consultant in order to ensure that the outside advisor
maintains its independence.

In addition to a compensation consultant, the compensation committee also solicits the input of
our management with respect to non-employee director compensation and certain aspects of executive compensation. For non-employee director compensation, management utilizes information compiled by us and surveys of director compensation to develop
recommendations that are then presented to the compensation committee and the entire board of directors. For base salaries of our executive officers other than the chief executive officer, our chief executive officer will make preliminary
recommendations to the compensation committee concerning any proposed adjustments to salary for the executive officers other than the chief executive officer. Also, in developing the annual incentive bonus plan, the compensation committee will
review managements preliminary recommendations concerning the performance objectives established pursuant to the plan. The compensation committee considers the advice of a compensation consultant and the recommendations of management, before
it determines executive and non-employee director compensation.

Survey Data

The published surveys utilized by Mercer detail compensation level and practices for positions within the labor markets in which we
typically hire our executive staff. Published survey sources utilized by Mercer in the analysis were:



| |  |  | MercerUS Global Premium Executive Remuneration Suite
| | - |  | -----------------------------------------------------



| |  |  | Presidio Pay Advisors, Inc.Biotechnology Industry Executive Compensation Survey
| | - |  | --------------------------------------------------------------------------------



| |  |  | ORC WorldwideSIRS Executive Compensation Survey
| | - |  | ------------------------------------------------



| |  |  | Watson Wyatt Data ServicesReports on Top Management Compensation
| | - |  | -----------------------------------------------------------------

Peer Group Data

The compensation committee also considered publicly available compensation data provided by our compensation consultant from similarly situated organizations in our industry. The primary factors used to
identify the peer group were our size relative to the peer group companies as compared by objective scope measures such as revenues, operating profit, headcount, and market capitalization. We also considered the business model of each company. We
believe that consideration of these comparison factors helps the compensation committee and management determine the competitiveness of our total compensation practices and levels compared to similarly situated organizations in our industry with
whom we compete for talent. The peers considered were as follows:



|                             |  |                               |  |                            
|---------------------------- |  | ----------------------------- |  | ---------------------------
|Cubist Pharmaceuticals, Inc. |  | Medicines Co.                 |  | Sciele Pharma, Inc.        
|CV Therapeutics, Inc.        |  | Momenta Pharmaceuticals, Inc. |  | Theravance, Inc.           
|Idenix Pharmaceuticals, Inc. |  | Salix Pharmaceuticals, Ltd.   |  | Vertex Pharmaceuticals Inc.



21



---

##### Table of Contents

Elements of Compensation

The compensation committee has adopted a mix among the compensation elements in order to further our compensation goals. The elements
include:



| |  |  | Base salary;
| | - |  | ------------



| |  |  | Variable compensation consisting of a cash bonus based upon individual and corporate performance; and
| | - |  | -----------------------------------------------------------------------------------------------------



| |  |  | Stock option grants with exercise prices set at the fair market value at the time of grant and vesting over a four year period.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------

The compensation committee believes this combination of elements provides reasonable fixed compensation on
which our executives can rely, while providing both short-term and long-term performance incentives. It is the intent of the compensation committee that base salary be set near the median range of the survey and peer group data and targeted annual
incentive level and the target long-term incentive award values be set slightly above the median range of the survey and peer group data. The compensation committee believes that setting compensation in these ranges is appropriate because it is
consistent with the compensation committees objective to make a significant portion of the pay for our named executive officers performance based. The compensation committee reviews information provided by the compensation consultant to
determine the appropriate levels and mix of compensation elements. The compensation committee also considers how risks taken by management could impact the value of executive compensation. In evaluating risk, the compensation committee considered
the percentage of compensation representing each of base salary, variable cash bonus and equity compensation and determined to maintain a balance between each of the elements of our compensation program. In 2009, annual compensation of our named
executive officers was comprised of base salary (25 to 28% of total compensation); variable cash bonus (13 to 14% of total compensation) and stock option grants with exercise prices set at the fair market value at the time of grant and vesting over
a four year period (57 to 62% of compensation).

Base Salary. Base salaries for our employees, including
our named executive officers, are evaluated on an annual basis in the first quarter of each year and are generally targeted near the median of the range of salaries for employees in similar positions with similar responsibilities at our peers. The
committee believes that establishing base salary at the median range of the survey and peer group data is appropriate because it is consistent with the compensation committees objective to make a significant portion of the pay for our named
executive officers performance based. In reviewing the base salaries of the named executive officers for 2009, the compensation committee reviewed a market assessment provided by Mercer which included information from the salary surveys and peer
group data described above. Our compensation committee also evaluated the expanded responsibilities of our named executive officers as a result of the companys growth and internal change, the expertise of the individual executive both as to
his or her position and in the industry generally, the competitiveness of the market for the executives services, the recommendations of our chief executive officer (except in the case of our chief executive officers own compensation),
and individual performance of the named executive officer. Increases in annual base salaries for 2009 were designed to maintain competitive compensation and motivate the executive to achieve the business objectives set for 2009.

The compensation committee set the 2009 base salary of Vincent J. Milano, our chief executive officer, at $500,000, an increase from his
2008 base salary of approximately 16.3%. Mr. Milano assumed the role of chief executive officer in March 2008 and in setting Mr. Milanos salary, the compensation committee recognized that the base salary of the chief executive
officer had been significantly below the median range of the survey and peer group data. The compensation committee desired to increase Mr. Milanos base salary to closer to the median. The compensation committee also recognized that
Mr. Milanos base salary remained below the median indicated by the survey data and peer group and agreed to regularly evaluate Mr. Milanos base salary as he gains additional experience as our chief executive officer. The base
salaries of our other named executive officers was increased by between 10.6% and 4.6%. Mr. Soland assumed the role of chief operating officer in March 2008 and received a base salary increase of 10.6% based upon his increased responsibilities
in this role as well as to bring his salary closer to the median of the of the survey and peer group data. Our chief strategic officer, received a base salary increase of 9.6% in order to bring his salary closer to the median of the survey and peer
group data.

The compensation committee met in January 2010 to evaluate performance for 2009 and determine whether an increase
in base salary of our named executive officers was warranted. The compensation committee took into account the competitive market data provided by the compensation consultant as well as the additional factors described above and provided each of the
named executive officers a 3.5% increase in base salary as set forth in the table under 2010 Direct Compensation Actions for Our Named Executive Officers below.

Variable Cash Bonus. We have a variable cash bonus plan covering each of our employees, including the named executive officers. Each employee is assigned a target payout, expressed as a
percentage of his or her base salary for the year, which varies by the employees role with us. We believe that the variable cash bonus opportunity should be set slightly above the median range of cash bonuses to executives at comparable
companies, while the actual amount of any cash bonus will be determined by our performance and the performance of the individual. The compensation committee believes that setting compensation in these ranges is appropriate because it is consistent
with the compensation committees objective to make a significant portion of the pay for our named executive officers performance based. Our named executive officers are eligible to receive a target bonus of 50% of their base salary, while the
actual amount of any cash bonus will be determined by our performance and the performance of the individual. The compensation committee provides that each named executive officers target bonus opportunity is the same in order to align their
incentives and preserve internal pay equity among them.



22



---

##### Table of Contents

The variable cash bonus plan consists of two factors: company and individual. Each of these
factors is itself separately weighted. The company factor represents the degree to which we achieved our overall corporate goals in a given year. Each employee is given an individual factor by his or her supervisor to reflect the employees
performance against his or her goals for the year. For the named executive officers, the company factor receives the highest weighting (70%) in order to ensure that the bonus system for our management team is closely tied to our performance
thereby aligning the interests of our executive officers with those of our stockholders. The individual factor, which is based on the employee performance, is given a 30% weighting.

Each factor can be assigned a value of up to 125% for maximum performance. Thus, depending on our performance and the individual
employee, he or she could receive up to 125% of the target bonus. In order for an individual to achieve in excess of 100% of their individual factor, such individual must demonstrate performance which is considered exceptional, which is
measured by surpassing all individual goals (115% to 125%) or exceeds, which is measured by achieving or surpassing all goals (101% to 114%).

An employees target bonus percentage is multiplied by the sum of the company factor and the employees individual factor. The result of that calculation is then multiplied by the
employees target bonus percentage to determine the actual bonus paid. Bonuses, if any, are paid during the first quarter of the year immediately following the year of measurement.

Our variable cash bonus plan includes several design features that reduce the likelihood of excessive risk taking including:



| |  |  | our overall corporate goals are established by the compensation committee at the beginning of the year and include a variety of clinical development,
pre-clinical and commercial objectives as well as financial performance oriented metrics, business development and compliance targets;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our cash bonus plan consists of two factorscompany and individual;
| | - |  | -------------------------------------------------------------------



| |  |  | all employees participate in the same cash bonus plan; and
| | - |  | ----------------------------------------------------------



| |  |  | our named executive officers are eligible to receive a target bonus of 50% of their base salary with a maximum limit on the amount of variable cash
bonus established at 62.5% of base salary which is achievable only in the event both the company and individual performance are considered exceptional.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The compensation committee intends that our goals be ambitious and are subject to the high risks associated with developing and commercializing pharmaceuticals. We expect that not all of our programs will
be successful, however, we establish our annual goals as if they will be. Accordingly, when measuring whether a goal has been achieved, the compensation committee may take into account the percentage of the goal completed as opposed to an all
or none approach.

The elements that the compensation committee established as our overall corporate goals in January
2009 included a variety of commercial objectives, clinical development and pre-clinical objectives, regulatory matters, financial performance oriented metrics, as well as business development and compliance targets. The commercial objectives
included net sales targets of $68 million for Cinryze and $237.6 for Vancocin, product contribution targets of $22 million for Cinryze, development of strategic plans for Cinryze and non-toxigenic Clostridium difficile (NTCD), completion of plasma
sourcing plans, and effective management of CinryzeSolutions and related patient programs. The financial metrics included operating income of $112 million and operating cash flow of $88 million. The financial metrics and Vancocin revenue target
would have been pro-rated had a generic version of Vancocin been approved by the FDA. The clinical development objectives included targets in NTCD related to initiating phase 1 clinical studies and achieving patient enrollment targets. Cinryze
clinical development plans related to commencement of a phase 4 study and a subcutaneous administration study. The approval of Cinryze for an acute indication was identified upside due to the significant levels of uncertainty arising
from the nature of the clinical data available and FDA comments. Preclinical development targets related to the NTCD program included initiation of toxicology studies and analytical methods work for NTCD. CMV program related milestones related to
the timing of analysis of clinical study data and development of pediatric dosage formulation.

The compensation committee
also evaluated other indications of performance in making compensation decisions as well, such as our progress in completing acquisitions or obtaining rights to drug candidates and ensuring compliance with applicable laws. In addition, the
compensation committee considered additional accomplishments including receipt of orphan designation for Cinryze in the E.U., progress in preparing for an MAA filing in the E.U., increasing manufacturing capacity for Cinryze, efforts to expand
rights



23



---

##### Table of Contents

to Cinryze in additional territories and indications and the reduction in company debt by $45 million. The compensation committee establishes the relevant weight of each category of goals in the
beginning of each year when the goals are established however, as a result of the clinical data received in February 2009, the compensation committee revised the weighting of the goals. The committee took into account the timing of the data,
importance of Cinryze to the company, need to encourage business development and need to motivate employees toward the revised business priorities when deciding to reallocate the weighting towards other priorities. The January weightings and revised
February weightings are each included in the table below. The compensation committee intends that our goals be ambitious and are subject to the high risks associated with developing and commercializing pharmaceuticals. We expect that not all of our
programs will be successful, however, we establish our annual goals as if they will be. The compensation committee establishes corporate goals which are intended to encourage company growth not only in the year for which the goals are established,
but also supportive of growth across the medium and long term and are not intended to encourage excessive risk taking. The specific annual performance goals reflect our confidential operating plan and information, reflecting our confidential
planning process, and, accordingly, to disclose these goals publicly would cause significant competitive harm to us.

Our
chief executive officer establishes the individual performance goals for the named executive officers other than himself. Each named executive officers individual goals relate to his or her responsibilities and duties based on their position
as those responsibilities and duties relate to the corporate goals established by the committee. The individual goals are intended to serve as supplemental measures to provide our named executive officers with guidance regarding our expectations for
2009 performance. The individual goals are not weighted or quantitative in and of themselves, other than that the individual performance factor represents 30% of each named executive officers bonus opportunity. After the end of the fiscal
year, our chief executive officer provides an assessment to the compensation committee of each named executive officers performance with respect his or her individual goals. The compensation committee reviews the chief executive officers
assessment and adjusts the level of performance (upward or downward) as it determines in its discretion based on its own assessment of each named executive officers performance. As noted above, in order for an individual to achieve in excess
of 100% of their individual factor, such individual must demonstrate performance which is considered exceptional, which is measured by surpassing all individual goals (115% to 125%) or exceeds, which is measured by achieving
or surpassing all goals (101% to 114%). With respect to the individual goals for our chief executive officer, for the past three years, our compensation committee has applied the company factor as our chief executive officers individual
performance factor based upon the belief the companys performance is representative of our chief executive officers individual performance as our chief executive officer is ultimately responsible for management of the company and its
performance.

For 2009, the individual performance goals for each our named executive officers (other than our chief executive
officer) were as follows:



|                                                |  |                                                                                                                                                                                                                                                                                                                                                                                 
|----------------------------------------------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Name                                            |  | 2009 Individual Performance Goals                                                                                                                                                                                                                                                                                                                                               
|Charles A. Rowland, VP, Chief Financial Officer |  | Managing financing arrangements including debt repurchases;  Maintaining and
improving financial controls, financial management, budgeting and forecasting;
 Development of the structure of our European
operations;  Managing information technology, facilities, and treasury functions.                                                                                     
|                                                | 
|Colin Broom, VP, Chief Scientific Officer       |  | Achieving milestones in the clinical development of NTCD;  Management of
clinical and medical affairs matters related to Vancocin; 
Management of clinical and medical affairs
matters related to Cinryze as well as clinical
aspects of Cinryze life cycle management
planning; and  Review of organization efficiencies in the clinical development and medical affairs
teams.



24



---

##### Table of Contents



|                                           |  |                                                                                                                                                                                                                                   
|------------------------------------------ |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Thomas F. Doyle, VP, Strategic Initiatives |  | Management of interactions with the FDA related to Vancocin;  Development of
company long term strategic planning; and 
Development of Cinryze life cycle management program.                                                     
|                                           | 
|Robert Pietrusko, VP, Regulatory           |  | Management of regulatory matters related to Cinryze including MAA filing in the EU and filings related to Cinryze manufacturing
capacity expansion.                                                                               
|                                           | 
|Daniel Soland, VP, Chief Operating Officer |  | Management of the commercial launch of Cinryze;  Management of
commercial programs related to Vancocin; and 
Management of technical operations group in
support of NTCD development and Cinryze
manufacturing capacity expansion.

In January 2010, the compensation committee considered the bonus compensation for 2009 performance and 2010 compensation matters. The compensation committee reviewed the successful commercial launch of
Cinryze, including revenue significantly in excess of the company goals, effective management of Cinryze Solutions and other patient related programs, the number of patients receiving Cinryze, the number of health plans providing reimbursement for
Cinryze and execution on manufacturing and plasma sourcing plans. The compensation committee also considered the continued Vancocin revenues, efforts to identify and negotiate additional business development opportunities, and our operating income
as well as operating cash flow. Additionally, the compensation committee observed that during 2009 progress was made in the advancement of our NTCD clinical development program. However, we were not able to advance our CMV program as a result of the
phase 3 clinical data received in February 2009. Finally, the compensation committee considered our efforts in conducting our business so that the company complies with laws and regulations and in accordance with our values.

These accomplishments reflected the efforts of our employees, including members of our executive team, and were taken into account by the
compensation committee in providing our executives with salary increases, equity grants and annual cash performance awards under our cash bonus program at 95% of our target. In making this determination, the compensation committee considered our
progress against the predefined bonus program goals and program weighting. Specifically, the compensation committee evaluated our achievements on a program basis as follows:



|                     |  |                          |     |   |                           |  |     |                    |  |  |    |  
|-------------------- |  | ------------------------ | --- | - | ------------------------- |  | --- | ------------------ |  |  | -- | -
|Goal                 |  | JanuaryPre-definedWeight |     |   | FebruaryPre-definedWeight |  |     | BonusDetermination | 
|Cinryze              |  |                          | 30  | % |                           |  | 50  | %                  |  |  | 60 | %
|Vancocin             |  |                          | 20  | % |                           |  | 20  | %                  |  |  | 16 | %
|Maribavir            |  |                          | 30  | % |                           |  | 5   | %                  |  |  | 1  | %
|NTCD                 |  |                          | 5   | % |                           |  | 5   | %                  |  |  | 3  | %
|Business Development |  |                          | 5   | % |                           |  | 20  | %                  |  |  | 7  | %
|Corporate            |  |                          | 10  | % |                           |  | 10  | %                  |  |  | 8  | %
|TOTAL                |  |                          | 100 | % |                           |  | 100 | %                  |  |  | 95 | %



25



---

##### Table of Contents

With respect to individual performance, the compensation committee determined that our chief
executive officers individual performance was 95%, the same level as the company factor for 2009. As noted above, for the past three years the compensation committee has applied the company factor as our chief executive officers
individual performance factor. The compensation committee, taking into account the recommendations of our chief executive officer, determined that the individual performance of our vice president of strategic initiatives and our chief
operating officer was within the exceptional range. For our vice president of strategic initiatives, our compensation committee determined that his individual performance was 125% as a result of continued Vancocin sales and the
successful integration of Lev Pharmaceuticals, Inc. For our chief operating officer, the compensation committee determined that his individual performance was 120% primarily as a result of the successful commercial launch of Cinryze and management
of the technical operations group in support of the Cinryze manufacturing capacity expansion and development of NTCD. The compensation committee determined that the individual performance for 2009 for our other executive officers was in the
exceeds range, based upon the achievement of their individual goals related to supporting the launch of Cinryze and managing our business. Specifically, for the fiscal year ended December 31, 2009, the compensation committee
determined that our Chief Financial Officers individual performance was 105% based on effective management of the companys debt, financial controls and forecasting procedures. The compensation committee determined that our Chief
Scientific Officers individual performance was 100% based on clinical development and medical affairs activities related to Cinryze, NTCD and Vancocin. In addition, the compensation committee determined that the individual performance of our
Vice President, Regulatory was 110% based on his management of regulatory matters related to Cinryze including the preparation for filing of a MAA for Cinryze in the European Union and support of filings related to our expansion of manufacturing
capacity for Cinryze.

Mr. Milano received a bonus for 2009 in the amount of $244,972, which equates to 95% of his target
bonus. The compensation committee also authorized the payment of bonuses to the other named executive officers who were officers for the entire year of 2009 which ranged from $172,640 to $193,360, as well as to all other employees. The full board
ratified the compensation committees salary and bonus determinations for Mr. Milano and the other named executive officers.

Stock Options.We believe that long-term performance is achieved through an ownership culture through the use of stock and stock-based awards that encourages performance by our executive
officers. Our stock incentive plans, consisting of our 2001 Equity Incentive Plan and 2005 Equity Incentive Plan, have been established to provide our employees, including our executive officers, with incentives that are intended to align their
interests with the interests of stockholders. We have not adopted stock ownership guidelines and our stock incentive plans have provided the principal method, other than through our employee stock purchase plan and open market purchases, for our
executive officers to acquire equity in our company.

We expect to continue to use stock options as a component of our
long-term incentive vehicle because:



| |  |  | Stock options help to provide a balance to the overall executive compensation program as base salary and our discretionary annual bonus program focus
on short-term compensation,
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Stock options align the interests of executives with those of the stockholders, support a pay-for-performance culture, foster employee stock ownership,
and focus the management team on increasing value for the stockholders.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Stock options are performance based. All the value received by the recipient of a stock option is based on the growth of the stock price.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The vesting period of stock options encourages employee retention and the preservation of stockholder value.
| | - |  | ------------------------------------------------------------------------------------------------------------

As with the variable cash bonus plan, our equity compensation is managed to reduce the likelihood of excessive risk taking. We believe
that long-term performance is achieved through an ownership culture through the use of stock and stock-based awards that encourages performance by our executive officers. Our stock incentive plans have been established to provide our employees,
including our executive officers, with incentives that are intended to align their interests with the interests of stockholders and reduce short term risk taking. Stock options are granted at the fair market value on the date of grant so that all
the value received by the recipient of a stock option is based on the growth of the stock price and we cannot reprice outstanding options granted under the 2005 Plan without the consent of our stockholders. In addition, stock options granted to
employees, including named executive officers, generally vest annually over four years in order to encourage employee retention and discourage short term risk taking.



26



---

##### Table of Contents

Our compensation committee oversees the administration of our stock option plans. Generally,
stock options are granted to all employees at the commencement of employment and twice annually, which practice was followed in 2009. Further, in general, grants of stock options are generally not awarded based on performance but are instead granted
as a matter of course as an overall component of compensation. Our stock incentive plans authorize us to grant options to purchase shares of common stock to our employees, directors and consultants. Stock options granted by us have an exercise price
equal to the fair market value of our common stock on the day of grant, typically vest over a four-year period with 25% vesting on each twelve month anniversary of the employment commencement date for new hire grants, and on each twelve month
anniversary of the grant date for annual grants made after an employees employment commencement date, in each case, subject to continued employment on each vesting date, and generally expire ten years after the date of grant. Fair market value
is defined to be the closing sale price during regular trading hours of a share of our common stock on the date of grant as reported on the NASDAQ Stock Market. Incentive stock options also include certain other terms necessary to assure compliance
with the Internal Revenue Code.

We do not have any program, plan or practice to time annual option grants to our executives
in coordination with the release of material non-public information. While we have historically made option grants twice annually, the compensation committee retains the discretion to make additional awards to employees, including named executive
officers, at other times, in connection with the initial hiring of a new officer, for retention purposes or otherwise. During 2009, the compensation committee determined to grant a larger percentage of options in January and a smaller percentage of
options in June in order to provide an incentive to employees to complete the analysis of the maribavir clinical data in a timely manner and to provide an incentive to employees during the critical early stages of the commercial launch of Cinryze.

In determining the number of stock options to be granted to executives, we take into account the individuals position,
scope of responsibility, ability to affect our performance, profits and stockholder value, peer group practice, the individuals historic and recent performance and the value of stock options in relation to other elements of the individual
executives total compensation. The compensation committee also considers the cost of equity awards and the projected impact on stockholder dilution. The target long-term incentive award values are set slightly above the median range of the
survey and peer group data. The compensation committee believes that setting compensation in these ranges is appropriate because it is consistent with the compensation committees objective to make a significant portion of the pay for our named
executive officers performance based. The responsibilities of Mr. Milano as our chief executive officer and Mr. Soland as our chief operating officer result in additional option grants. The remaining named executive officers receive an
equivalent number of options.

In January 2009, the compensation committee awarded Mr. Milano options to purchase 84,000
shares of common stock. Also in January 2009, the compensation committee awarded our chief operating officer options to purchase 75,000 shares of common stock and granted all of the other named executive officers options to purchase 60,000 shares of
common stock. Each of the January grants were made at an exercise price of $13.50. In June 2010, the compensation committee awarded Mr. Milano options to purchase 56,000 shares of common stock. Also in June, the compensation committee awarded
our chief operating officer options to purchase 50,000 shares of common stock and granted all of the other named executive officers options to purchase 40,000 shares of common stock. Each of the June option grants were made at an exercise price of
$5.91.

During the second quarter of 2010, the compensation committee engaged Mercer to evaluate current trends in the
utilization of equity compensation, including the use of stock options, restricted stock and restricted stock units. The compensation committee intends to evaluate the data to be presented by Mercer in connection with making equity grants in June
2010.

Other Compensation. We provide the following benefits to our executive officers generally on the
same basis as the benefits provided to all employees:



| |  |  | Health, vision and dental insurance;
| | - |  | ------------------------------------



| |  |  | Life insurance;
| | - |  | ---------------



| |  |  | Disability insurance;
| | - |  | ---------------------



| |  |  | 401(k) with company match; and
| | - |  | ------------------------------



| |  |  | Employee stock purchase plan providing for the opportunity to purchase our common stock at a discount to market price.
| | - |  | ----------------------------------------------------------------------------------------------------------------------

We believe that these benefits are consistent with those offered by other companies, specifically those provided by our peers.
Occasionally, certain executives separately negotiate other benefits in addition to the benefits described above, such as reimbursement of relocation expenses. No such additional benefits were provided in 2009.



27



---

##### Table of Contents

2010 Direct Compensation Actions for Our Named Executive Officers

We do not have employment agreements with any of our executive officers. Base salaries for each of our executive officers are reviewed and
approved on at least an annual basis by the compensation committee and ratified by the board of directors. The following table reflects the compensation actions taken as of January 2010.



|                   |  |             |         |  |                   |  |     |               |  |  |               |   |  |  |         | 
|------------------ |  | ----------- | ------- |  | ----------------- |  | --- | ------------- |  |  | ------------- | - |  |  | ------- | 
|                   |  | Base Salary |         |  | Cash Bonus Target |  |     | Equity Awards | 
|Name               |  | 2010 Salary |         |  | % Change          |  |     | 2010 Target   |  |  | Stock Options |  
|Vincent J. Milano  |  | $           | 517,500 |  |                   |  | 3.5 | %             |  |  | 50            | % |  |  | 180,000 | 
|Colin Broom        |  | $           | 367,426 |  |                   |  | 3.5 | %             |  |  | 50            | % |  |  | 100,000 | 
|Thomas F. Doyle    |  | $           | 341,550 |  |                   |  | 3.5 | %             |  |  | 50            | % |  |  | 125,000 | 
|Robert Pietrusko   |  | $           | 362,251 |  |                   |  | 3.5 | %             |  |  | 50            | % |  |  | 100,000 | 
|Charles A. Rowland |  | $           | 351,900 |  |                   |  | 3.5 | %             |  |  | 50            | % |  |  | 100,000 | 
|Daniel Soland      |  | $           | 377,775 |  |                   |  | 3.5 | %             |  |  | 50            | % |  |  | 125,000 | 

Tax and
Accounting Considerations for Executive Compensation

The compensation paid to our executives is generally subject to
taxation at ordinary rates and no particular attempt is made to alter that result. We do, however, attempt to structure our arrangements so that our executives are not subject to tax penalties (such as additional taxes arising under
Section 409A of the Internal Revenue Code), although our efforts in this regard have not materially affected the terms of our compensation arrangements.

Section 162(m) of the Internal Revenue Code of 1986, as amended, generally denies a federal income tax deduction for certain compensation exceeding $1,000,000 paid to the named executive officers,
excluding, among other things, certain performance-based compensation. Through December 31, 2009, this provision has not affected our tax deductions, and we believe that, at the present time, it is unlikely, although possible, that the
compensation paid to any of our employees in a taxable year which is subject to the deduction limit will exceed $1,000,000. The compensation committee has not purposefully altered its compensation approach to conform to the requirements of available
Section 162(m) exemptions, although historically, all stock option awards made under our equity compensation plans were structured and administered in a manner intended to comply with the performance-based exception to Section 162(m). The
compensation committee intends to continue to evaluate the effects of the statute and any applicable regulations in the future to ensure that the application of the statute and these regulations are consistent with our best interests.

We include the accounting impact of equity awards as required by the accounting standards for share based compensation in our financial
statements. The non-cash accounting charge for equity compensation has not been a primary factor considered in determining the size of individual awards or the equity awards granted to employees, consultants and directors company-wide. We endeavor
to design our equity incentive awards conventionally, so that they are accounted for under standard governing equity-based arrangements and, more specifically, so that they are afforded fixed treatment under those standards. We have not, however,
materially altered the design of our awards as a result of recent changes to the standard for accounting for equity-based compensation. We will continue to carefully quantify and monitor the non-cash accounting expense of our equity programs.

Change of Control Agreements, Severance Agreement and Severance Plan

We do not have employment agreements with our executive officers, however, we have entered into change of control agreements with our
executive officers.

The compensation committee believes that the change of control agreements are an important part of our
overall compensation program for our executive officers. The compensation committee believes that these agreements will help to secure the continued employment and dedication of our executive officers, notwithstanding any concern that they might
have at such time regarding their own continued employment, prior to or following a change of control. The compensation committee also believes that these agreements are important as a recruitment and retention device, as most of the companies in
our peer group with which we compete for executive talent have similar agreements in place for their executive officers. For a more detailed discussion of the terms of these agreements, including the amounts payable under these agreements to our
named executive officers, please refer to the section 2009 Potential Payments Upon Termination or Change of Control on page 37.



28



---

##### Table of Contents

Our equity incentive plans under which we have issued equity awards to our employees provide
for accelerated vesting of stock under certain circumstances in connection with a change of control of us. If a change of control occurs and the equity incentive plan is not continued by a successor corporation, all unvested options become vested
for employees who have been employed by us for at least two years, and 50% of such unvested options become vested for employees with less than two years of service.



| |  |  | If a change of control occurs and our plan is continued by a successor corporation, or if our participants receive equivalent, substituted stock
options or restricted shares in a successor corporation, then if the participant is not offered substantially equivalent employment with the successor corporation, all unvested options become vested for employees who have been employed by us for at
least two years, and 50% of such unvested options become vested for employees with less than two years of service.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | If any participant is offered substantially equivalent employment with the successor corporation, both in terms of duties and compensation, then his or
her options will not be subject to accelerated vesting and the restrictions on his or her restricted shares will not lapse. If that participants employment with
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

the successor corporation is terminated during the six month period following the change of control, however, then any unvested options
and restricted shares held as of the date of termination will be treated in the manner described above (i.e., all options will vest and the restrictions on all restricted shares will lapse if the participant was employed for at least two years; 50%
of the options will vest and the restrictions on 50% of the restricted shares will lapse if the participant was employed for less than two years).

The following report of the compensation committee will not be deemed incorporated by reference by any general statement incorporating by reference this proxy statement into any filing under the
Securities Act of 1933, as amended, or under the Securities Exchange Act of 1934, as amended, except to the extent that we specifically incorporate this information by reference. The following report shall not otherwise be deemed filed under such
acts.

REPORT OF THE COMPENSATION COMMITTEE

The compensation committee of the board of directors has reviewed and discussed the Compensation Discussion and Analysis required by
Item 402(b) of Regulation S-K with management and, based on that review and discussions, the compensation committee recommended to the board of directors that the Compensation Discussion and Analysis be included in this annual report on
Form 10-K/A.



MEMBERS OF THE COMPENSATION     COMMITTEERobert J. Glaser (Committee Chairman)William D. Claypool, M.D.


December 3, 2010



29



---

##### Table of Contents

Executive Compensation

The following table provides information on the compensation during the fiscal year ended December 31, 2009 of our chief executive officer, chief financial officer and our four other most highly
compensated executive officers as of the end of fiscal year.

Summary Compensation Table



|                             |  |      |      |  |           |   |         |          |  |  |                |  |  |                    |   |  |                                            |   |           |                                         |  |   |                             |  |  |          |   |  |  |   |        |  |  |   |           | 
|---------------------------- |  | ---- | ---- |  | --------- | - | ------- | -------- |  |  | -------------- |  |  | ------------------ | - |  | ------------------------------------------ | - | --------- | --------------------------------------- |  | - | --------------------------- |  |  | -------- | - |  |  | - | ------ |  |  | - | --------- | 
|Name & Principal Position    |  | Year |      |  | Salary($) |   |         | Bonus($) |  |  | StockAwards($) |  |  | OptionAwards($)(1) |   |  | Non-EquityIncentive PlanCompensation($)(2) |   |           | ChangeinPensionValuedandNQDCEarnings($) |  |   | All OtherCompensation($)(3) |  |  | Total($) |  
|Vincent J. Milano            |  |      | 2009 |  |           | $ | 500,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 1,006,157 |                                         |  | $ | 244,972                     |  |  |          |  |  |  | $ | 3,750  |  |  | $ | 1,754,879 | 
|Chief Executive Officer(4)   |  |      | 2008 |  |           | $ | 430,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 1,071,572 |                                         |  | $ | 231,770                     |  |  |          |  |  |  | $ | 3,750  |  |  | $ | 1,737,092 | 
|                             |  |      | 2007 |  |           | $ | 315,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 1,215,165 |                                         |  | $ | 141,750                     |  |  |          |  |  |  | $ | 3,750  |  |  | $ | 1,675,665 | 
|Charles A. Rowland(5)        |  |      | 2009 |  |           | $ | 340,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 718,684   |                                         |  | $ | 172,640                     |  |  |          |  |  |  | $ | 3,334  |  |  | $ | 1,234,658 | 
|VP, Chief Financial Officer  |  |      | 2008 |  |           | $ | 50,000  |          |  |  |               |  |  |                    |  |  |                                            | $ | 837,820   |                                         |  | $ | 27,625                      |  |  |          |  |  |  | $ |       |  |  | $ | 915,445   | 
|                             |  |      | 2007 |  |           |   |        |          |  |  |               |  |  |                    |  |  |                                            |   |          |                                         |  |   |                            |  |  |          |  |  |  | $ |       |  |  |   |          | 
|Colin Broom                  |  |      | 2009 |  |           | $ | 355,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 718,684   |                                         |  | $ | 177,441                     |  |  |          |  |  |  | $ | 3,750  |  |  | $ | 1,254,875 | 
|VP, Chief Scientific Officer |  |      | 2008 |  |           | $ | 337,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 574,097   |                                         |  | $ | 193,775                     |  |  |          |  |  |  | $ | 3,750  |  |  | $ | 1,108,622 | 
|                             |  |      | 2007 |  |           | $ | 327,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 923,640   |                                         |  | $ | 142,245                     |  |  |          |  |  |  | $ | 3,750  |  |  | $ | 1,396,635 | 
|Thomas F. Doyle              |  |      | 2009 |  |           | $ | 330,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 718,684   |                                         |  | $ | 177,446                     |  |  |          |  |  |  | $ | 3,750  |  |  | $ | 1,229,880 | 
|VP, Strategic Initiatives    |  |      | 2008 |  |           | $ | 301,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 574,097   |                                         |  | $ | 173,075                     |  |  |          |  |  |  | $ | 3,750  |  |  | $ | 1,051,922 | 
|                             |  |      | 2007 |  |           | $ | 290,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 923,640   |                                         |  | $ | 134,850                     |  |  |          |  |  |  | $ | 2,523  |  |  | $ | 1,351,013 | 
|Robert Pietrusko(6)          |  |      | 2009 |  |           | $ | 350,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 718,684   |                                         |  | $ | 180,282                     |  |  |          |  |  |  | $ | 3,750  |  |  | $ | 1,252,716 | 
|VP, Regulatory               |  |      | 2008 |  |           | $ | 328,300 |          |  |  |               |  |  |                    |  |  |                                            | $ | 574,097   |                                         |  | $ | 188,773                     |  |  |          |  |  |  | $ | 3,750  |  |  | $ | 1,094,920 | 
|                             |  |      | 2007 |  |           | $ | 193,735 |          |  |  |               |  |  |                    |  |  |                                            | $ | 1,335,280 |                                         |  | $ | 93,009                      |  |  |          |  |  |  | $ | 94,729 |  |  | $ | 1,716,753 | 
|Daniel Soland                |  |      | 2009 |  |           | $ | 365,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 898,355   |                                         |  | $ | 193,360                     |  |  |          |  |  |  | $ | 3,750  |  |  | $ | 1,460,465 | 
|VP, Chief Operating Officer  |  |      | 2008 |  |           | $ | 330,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 765,422   |                                         |  | $ | 192,225                     |  |  |          |  |  |  | $ | 3,750  |  |  | $ | 1,291,397 | 
|                             |  |      | 2007 |  |           | $ | 260,000 |          |  |  |               |  |  |                    |  |  |                                            | $ | 923,640   |                                         |  | $ | 117,000                     |  |  |          |  |  |  | $ | 3,750  |  |  | $ | 1,304,390 | 



|(1) | These columns show the grant date fair value of awards computed in accordance with stock-based compensation accounting rules (FASB ASC Topic 718). A discussion of
assumptions used in calculating award values may be found in Note 12 to our 2009 audited financial statements in our Form 10-K.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | The amounts shown in this column constitute awards earned in 2009 under the 2009 Cash Bonus Plan; amounts earned were paid in January 2010. For a further discussion of
these awards, see the Compensation Discussion and Analysis beginning on page 22 of this proxy statement.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | Represents contributions made by us on behalf of such person to our 401(k) plan for each of the named executives other than Robert Pietrusko. The amounts shown in this
column for Dr. Pietrusko include contributions made by us on his behalf to our 401(k) plan of $1,108 and reimbursement of $93,621 of relocation expenses in 2007 including all moving expenses related to the relocation of his residence and paying
for the closing costs on both the sale of his existing home in Massachusetts and the closing costs associated with the purchase of a new home in Pennsylvania.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(4) | Mr. Milano assumed the role of chief executive officer on March 31, 2008. Prior thereto he served as our chief operating officer and chief financial officer.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------

|(5) | Mr. Rowland joined the company in October 2008 and his salary and cash bonus payment for 2008 were prorated to reflect the length of his employment during the
fiscal year.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | Dr. Pietrusko joined the company in April 2007 and his salary and cash bonus payment for 2007 were prorated to reflect the length of his employment during the
fiscal year.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Base Salary and Incentive Plan Cash Bonus as a Proportion of Total Compensation

The following table sets forth the base salary and incentive plan cash bonus as a proportion of total compensation for each of the named
executive officers in 2009:



|                   |  |                        |         |  |                   |   |           |                                                          |  |  |      |  
|------------------ |  | ---------------------- | ------- |  | ----------------- | - | --------- | -------------------------------------------------------- |  |  | ---- | -
|                   |  | Base Salaryplus 
Bonus |         |  | TotalCompensation |   |           | Base Salary andBonus 
as aProportion ofTotalCompensation | 
|Vincent J. Milano  |  | $                      | 744,972 |  |                   | $ | 1,754,879 |                                                          |  |  | 42.4 | %
|Colin Broom        |  | $                      | 532,441 |  |                   | $ | 1,254,875 |                                                          |  |  | 42.4 | %
|Thomas F. Doyle    |  | $                      | 507,446 |  |                   | $ | 1,229,880 |                                                          |  |  | 41.3 | %
|Robert Pietrusko   |  | $                      | 530,282 |  |                   | $ | 1,252,716 |                                                          |  |  | 42.3 | %
|Charles A. Rowland |  | $                      | 512,640 |  |                   | $ | 1,234,658 |                                                          |  |  | 41.5 | %
|Daniel Soland      |  | $                      | 558,360 |  |                   | $ | 1,460,465 |                                                          |  |  | 38.2 | %



30



---

##### Table of Contents

Grants Of Plan Based Awards



|                             |  |           |                    |  |                                                                 |  |   |                                                         |  |   |                                                       |  |  |                                                                    |         |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  |              |  |  |    |           |  |  |    |                | 
|---------------------------- |  | --------- | ------------------ |  | --------------------------------------------------------------- |  | - | ------------------------------------------------------- |  | - | ----------------------------------------------------- |  |  | ------------------------------------------------------------------ | ------- |  | ----------------------------------------- |  |  | -------------------------------------------- |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ------------ |  |  | -- | --------- |  |  | -- | -------------- | 
|Name                         |  | GrantDate |                    |  | EstimatedFuture 
PayoutsUnderNon-Equity IncentivePlan
Awards(1) |  |   | EstimatedFuture PayoutsUnderEquity IncentivePlan Awards |  |   | AllOtherStockAwards:NumberofSharesof Stockor Units(#) |  |  | All OtherOptionAwards:Number
ofSecuritiesofUnderlyingOptions(#)(2) |         |  | Exerciseor BasePrice ofOptionAwards($/Sh) |  |  | GrantDateFairValue ofStockandOptionAwards($) | 
|                             |  |           |                    |  | Threshold($)                                                    |  |   | Target($)                                               |  |   | Maximum($)                                            |  |  | Threshold($)                                                       |         |  | Target($)                                 |  |  | Maximum($)                                   |  |  |  |  |  |  |  |  |  |  |  |  | 
|Vincent J. Milano,           |  |           | N.A.               |  |                                                                 |  |  |                                                         |  | $ | 250,000                                               |  |  | $                                                                  | 312,500 |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  |              |  |  |    |           |  |  |    |                | 
|Chief Executive Officer      |  |           | 6/11/2009          |  |                                                                 |  |   |                                                         |  |   |                                                       |  |  |                                                                    |         |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 56,000       |  |  | $  | 5.91      |  |  | $  | 233,542        | 
|                             |  |           | 1/08/2009          |  |                                                                 |  |   |                                                         |  |   |                                                       |  |  |                                                                    |         |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 84,000       |  |  | $  | 13.50     |  |  | $  | 772,615        | 
|Charles A. Rowland,          |  |           | N.A.               |  |                                                                 |  |  |                                                         |  | $ | 170,000                                               |  |  | $                                                                  | 212,500 |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  |              |  |  |    |           |  |  |    |                | 
|VP, Chief Financial Officer  |  |           | 6/11/20091/08/2009 |  |                                                                 |  |   |                                                         |  |   |                                                       |  |  |                                                                    |         |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 40,00060,000 |  |  | $$ | 5.9113.50 |  |  | $$ | 166,816551,867 | 
|Colin Broom,                 |  |           | N.A.               |  |                                                                 |  |  |                                                         |  | $ | 177,500                                               |  |  | $                                                                  | 221,875 |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  |              |  |  |    |           |  |  |    |                | 
|VP, Chief Scientific Officer |  |           | 6/11/2009          |  |                                                                 |  |   |                                                         |  |   |                                                       |  |  |                                                                    |         |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 40,000       |  |  | $  | 5.91      |  |  | $  | 166,816        | 
|                             |  |           | 1/08/2009          |  |                                                                 |  |   |                                                         |  |   |                                                       |  |  |                                                                    |         |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 60,000       |  |  | $  | 13.50     |  |  | $  | 551,867        | 
|Thomas F. Doyle,             |  |           | N.A.               |  |                                                                 |  |  |                                                         |  | $ | 165,000                                               |  |  | $                                                                  | 206,250 |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  |              |  |  |    |           |  |  |    |                | 
|VP, Strategic Initiatives    |  |           | 6/11/2009          |  |                                                                 |  |   |                                                         |  |   |                                                       |  |  |                                                                    |         |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 40,000       |  |  | $  | 5.91      |  |  | $  | 166,816        | 
|                             |  |           | 1/08/2009          |  |                                                                 |  |   |                                                         |  |   |                                                       |  |  |                                                                    |         |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 60,000       |  |  | $  | 13.50     |  |  | $  | 551,867        | 
|Daniel Soland,               |  |           | N.A.               |  |                                                                 |  |  |                                                         |  | $ | 182,500                                               |  |  | $                                                                  | 228,125 |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  |              |  |  |    |           |  |  |    |                | 
|VP, Chief Operating Officer  |  |           | 6/11/2009          |  |                                                                 |  |   |                                                         |  |   |                                                       |  |  |                                                                    |         |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50,000       |  |  | $  | 5.91      |  |  | $  | 205,520        | 
|                             |  |           | 1/08/2009          |  |                                                                 |  |   |                                                         |  |   |                                                       |  |  |                                                                    |         |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 75,000       |  |  | $  | 13.50     |  |  | $  | 689,834        | 
|Robert Pietrusko             |  |           | N.A.               |  |                                                                 |  |  |                                                         |  | $ | 175,000                                               |  |  | $                                                                  | 218,750 |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  |              |  |  |    |           |  |  |    |                | 
|VP, Regulatory               |  |           | 6/11/2009          |  |                                                                 |  |   |                                                         |  |   |                                                       |  |  |                                                                    |         |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 40,000       |  |  | $  | 5.91      |  |  | $  | 166,816        | 
|                             |  |           | 1/08/2009          |  |                                                                 |  |   |                                                         |  |   |                                                       |  |  |                                                                    |         |  |                                           |  |  |                                              |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 60,000       |  |  | $  | 13.50     |  |  | $  | 551,867        | 



|(1) | Represents the range of possible payments under the Cash Bonus Plan. For 2009, the compensation committee granted awards to the named executive officers under the Cash
Bonus Plan, all of which are reported as Non-Equity Incentive Plan Compensation in the 2009 Summary Compensation Table located on page 33 of this proxy statement.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | Consists of stock options awarded during 2009 under our 2005 Equity Incentive Plan. The stock option awards vest 25% on each of the first four anniversaries of the
grant date. The stock options have a ten-year term and an exercise price equal to the closing market price of the our common stock on the date of grant.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Stock Option Grants:The stock options granted in fiscal year 2009 to the named executive officers have an exercise price equal to the fair market value of our common stock on the day of grant,
vest over a four-year period with 25% vesting on each twelve month anniversary of the grant date, subject to continued employment, and expire ten years after the date of grant. Fair market value is defined to be the closing sale price during regular
trading hours of a share of our common stock on the date of grant as reported on the NASDAQ Stock Market. In determining the number of stock options to be granted to executives, our compensation committee takes into account the individuals
position, scope of responsibility, ability to affect profits and stockholder value, peer group practice, the individuals historic and recent performance and the value of stock options in relation to other elements of the individual
executives total compensation. The compensation committee also considers the cost of equity awards and the projected impact on shareholder dilution.

Cash Bonus Plan Awards:During 2009, the compensation committee approved the awards under our Cash Bonus Plan, which provided our executive officers, including our chief executive officer, with the
opportunity to earn a cash incentive award if certain pre-established objectives were attained. For 2009, each of our executive officers other than our chief executive officer earned a bonus amount that was at or above the target bonus levels
established under the Cash Bonus Plan. Our chief executive officer received a bonus equal to 95% of our target bonus level established under the Cash Bonus Plan. The bonus amounts earned by our executive officers are reported as Non-Equity
Incentive Plan Compensation in the 2009 Summary Compensation Table above.



31



---

##### Table of Contents

Outstanding Equity Awards At Fiscal Year End



|                             |  |                                                                |         |  |                                                                     |  |        |                                                                                        |  |  |                        |  |  |                      |       |  |                                                       |  |             |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|---------------------------- |  | -------------------------------------------------------------- | ------- |  | ------------------------------------------------------------------- |  | ------ | -------------------------------------------------------------------------------------- |  |  | ---------------------- |  |  | -------------------- | ----- |  | ----------------------------------------------------- |  | ----------- | ------------------------------------------------------------- |  |  | ------------------------------------------------------------------------------------------ |  |  | ------------------------------------------------------------------------------------------------------------- |  |  |  |  |  |  |  |  |  | 
|                             |  | Option Awards                                                  |         |  | Stock Awards                                                        | 
|Name                         |  | Number ofSecuritiesUnderlyingUnexercisedOptions (#)Exercisable |         |  | Number ofSecuritiesUnderlyingUnexercisedOptions
(#)Unexercisable(1) |  |        | EquityIncentive PlanAwards:Number
ofSecuritiesUnderlyingUnexercisedUnearnedOptions (#) |  |  | OptionExercisePrice($) |  |  | OptionExpirationDate |       |  | Number ofShares orUnits ofStockThat HaveNotVested
(#) |  |             | Market Valueof Shares orUnits of StockThat Have NotVested
($) |  |  | EquityIncentivePlanAwards:NumberofUnearnedShares,Units
orOtherRightsThatHave NotVested (#) |  |  | EquityIncentivePlan Awards:Market orPayout Valueof UnearnedShares,
Unitsor OtherRights thatHave NotVested (#) | 
|Vincent J. Milano,           |  |                                                                | 0       |  |                                                                     |  | 56,000 |                                                                                        |  |  |                        |  |  | $                    | 5.91  |  |                                                       |  | 6/11/2019   |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|VP, Chief Executive Officer  |  |                                                                | 0       |  |                                                                     |  | 84,000 |                                                                                        |  |  |                        |  |  | $                    | 13.50 |  |                                                       |  | 01/8/2019   |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 28,750  |  |                                                                     |  | 86,250 |                                                                                        |  |  |                        |  |  | $                    | 9.99  |  |                                                       |  | 06/13/2018  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 6,250   |  |                                                                     |  | 18,750 |                                                                                        |  |  |                        |  |  | $                    | 9.96  |  |                                                       |  | 0 1/11/2018 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 25,000  |  |                                                                     |  | 25,000 |                                                                                        |  |  |                        |  |  | $                    | 13.97 |  |                                                       |  | 06/15/2017  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 27,500  |  |                                                                     |  | 27,500 |                                                                                        |  |  |                        |  |  | $                    | 15.24 |  |                                                       |  | 01/12/2017  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 45,000  |  |                                                                     |  | 15,000 |                                                                                        |  |  |                        |  |  | $                    | 8.71  |  |                                                       |  | 08/03/2016  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 45,000  |  |                                                                     |  | 15,000 |                                                                                        |  |  |                        |  |  | $                    | 19.73 |  |                                                       |  | 01/17/2016  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 40,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 7.05  |  |                                                       |  | 06/21/2015  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 60,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 3.14  |  |                                                       |  | 01/21/2015  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 100,000 |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 3.55  |  |                                                       |  | 01/15/2014  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 30,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 2.09  |  |                                                       |  | 0 7/22/2013 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 1       |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 0.99  |  |                                                       |  | 10/10/1012  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 20,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 3.93  |  |                                                       |  | 04/16/2012  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 10,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 20.16 |  |                                                       |  | 0 1/14/2012 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 8,000   |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 29.37 |  |                                                       |  | 07/24/2011  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 10,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 14.12 |  |                                                       |  | 01/01/2011  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 21,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 37.12 |  |                                                       |  | 01/03/2010  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|Charles A. Rowland,          |  |                                                                | 0       |  |                                                                     |  | 40,000 |                                                                                        |  |  |                        |  |  | $                    | 5.91  |  |                                                       |  | 06/11/2019  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|VP, Chief Financial Officer  |  |                                                                | 0       |  |                                                                     |  | 60,000 |                                                                                        |  |  |                        |  |  | $                    | 13.50 |  |                                                       |  | 01/08/2019  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 15,000  |  |                                                                     |  | 85,000 |                                                                                        |  |  |                        |  |  | $                    | 11.96 |  |                                                       |  | 10/20/2018  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|Colin Broom,                 |  |                                                                | 0       |  |                                                                     |  | 40,000 |                                                                                        |  |  |                        |  |  | $                    | 5.91  |  |                                                       |  | 06/11/2019  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|VP, Chief Scientific Officer |  |                                                                | 0       |  |                                                                     |  | 60,000 |                                                                                        |  |  |                        |  |  | $                    | 13.50 |  |                                                       |  | 01/08/2019  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 13,750  |  |                                                                     |  | 41,250 |                                                                                        |  |  |                        |  |  | $                    | 9.99  |  |                                                       |  | 06/13/2018  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 5,000   |  |                                                                     |  | 15,000 |                                                                                        |  |  |                        |  |  | $                    | 9.96  |  |                                                       |  | 01/11/2018  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 20,000  |  |                                                                     |  | 20,000 |                                                                                        |  |  |                        |  |  | $                    | 13.97 |  |                                                       |  | 06/15/2017  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 20,000  |  |                                                                     |  | 20,000 |                                                                                        |  |  |                        |  |  | $                    | 15.24 |  |                                                       |  | 01/12/2017  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 37,500  |  |                                                                     |  | 15,000 |                                                                                        |  |  |                        |  |  | $                    | 8.71  |  |                                                       |  | 08/0/3/2016 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 30,000  |  |                                                                     |  | 10,000 |                                                                                        |  |  |                        |  |  | $                    | 19.73 |  |                                                       |  | 01/17/2016  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 40,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 7.05  |  |                                                       |  | 06/21/2015  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 44,616  |  |                                                                     |  |        |                                                                                        |  |  |                        |  |  | $                    | 3.14  |  |                                                       |  | 01/21/2015  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 150,000 |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 1.84  |  |                                                       |  | 05/10/2014  |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 



32



---

##### Table of Contents

|                             |  |                                                                |         |  |                                                                     |  |        |                                                                                        |  |  |                        |  |  |                      |       |  |                                                       |  |            |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|---------------------------- |  | -------------------------------------------------------------- | ------- |  | ------------------------------------------------------------------- |  | ------ | -------------------------------------------------------------------------------------- |  |  | ---------------------- |  |  | -------------------- | ----- |  | ----------------------------------------------------- |  | ---------- | ------------------------------------------------------------- |  |  | ------------------------------------------------------------------------------------------ |  |  | ------------------------------------------------------------------------------------------------------------- |  |  |  |  |  |  |  |  |  | 
|                             |  | Option Awards                                                  |         |  | Stock Awards                                                        | 
|Name                         |  | Number ofSecuritiesUnderlyingUnexercisedOptions (#)Exercisable |         |  | Number ofSecuritiesUnderlyingUnexercisedOptions (#)Unexercisable(1) |  |        | EquityIncentive PlanAwards:Number
ofSecuritiesUnderlyingUnexercisedUnearnedOptions (#) |  |  | OptionExercisePrice($) |  |  | OptionExpirationDate |       |  | Number ofShares orUnits ofStockThat HaveNotVested (#) |  |            | Market Valueof Shares orUnits of StockThat Have NotVested
($) |  |  | EquityIncentivePlanAwards:NumberofUnearnedShares,Units
orOtherRightsThatHave NotVested (#) |  |  | EquityIncentivePlan Awards:Market orPayout Valueof UnearnedShares, Unitsor
OtherRights thatHave NotVested (#) | 
|Thomas F. Doyle,             |  |                                                                | 0       |  |                                                                     |  | 40,000 |                                                                                        |  |  |                        |  |  | $                    | 5.91  |  |                                                       |  | 06/11/2019 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|VP, Strategic Initiatives    |  |                                                                | 0       |  |                                                                     |  | 60,000 |                                                                                        |  |  |                        |  |  | $                    | 13.50 |  |                                                       |  | 01/08/2019 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 13,750  |  |                                                                     |  | 41,250 |                                                                                        |  |  |                        |  |  | $                    | 9.99  |  |                                                       |  | 06/13/2018 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 5,000   |  |                                                                     |  | 15,000 |                                                                                        |  |  |                        |  |  | $                    | 9.96  |  |                                                       |  | 01/11/2018 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 20,000  |  |                                                                     |  | 20,000 |                                                                                        |  |  |                        |  |  | $                    | 13.97 |  |                                                       |  | 06/15/2017 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 20,000  |  |                                                                     |  | 20,000 |                                                                                        |  |  |                        |  |  | $                    | 15.24 |  |                                                       |  | 01/12/2017 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 37,500  |  |                                                                     |  | 15,000 |                                                                                        |  |  |                        |  |  | $                    | 8.71  |  |                                                       |  | 08/03/2016 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 30,000  |  |                                                                     |  | 10,000 |                                                                                        |  |  |                        |  |  | $                    | 19.73 |  |                                                       |  | 01/17/2016 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 40,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 7.05  |  |                                                       |  | 06/21/2015 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 60,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 3.14  |  |                                                       |  | 01/21/2015 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 100,000 |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 3.55  |  |                                                       |  | 01/15/2014 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 30,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 2.09  |  |                                                       |  | 07/22/2013 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 20,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 3.93  |  |                                                       |  | 04/16/2012 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 10,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 20.16 |  |                                                       |  | 01/14/2012 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 8,000   |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 29.37 |  |                                                       |  | 07/24/2011 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 10,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 14.12 |  |                                                       |  | 01/01/2011 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 21,000  |  |                                                                     |  | 0      |                                                                                        |  |  |                        |  |  | $                    | 37.12 |  |                                                       |  | 01/03/2010 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|Daniel Soland,               |  |                                                                | 0       |  |                                                                     |  | 50,000 |                                                                                        |  |  |                        |  |  | $                    | 5.91  |  |                                                       |  | 06/11/2019 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|VP, Chief Commercial Officer |  |                                                                | 0       |  |                                                                     |  | 75,000 |                                                                                        |  |  |                        |  |  | $                    | 13.50 |  |                                                       |  | 01/08/2019 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 20,000  |  |                                                                     |  | 60,000 |                                                                                        |  |  |                        |  |  | $                    | 9.99  |  |                                                       |  | 06/13/2018 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 20,000  |  |                                                                     |  | 20,000 |                                                                                        |  |  |                        |  |  | $                    | 15.24 |  |                                                       |  | 01/12/2017 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 75,000  |  |                                                                     |  | 25,000 |                                                                                        |  |  |                        |  |  | $                    | 12.83 |  |                                                       |  | 11/06/2016 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|Robert Pietrusko,            |  |                                                                | 0       |  |                                                                     |  | 40,000 |                                                                                        |  |  |                        |  |  | $                    | 5.91  |  |                                                       |  | 06/11/2019 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|VP, Regulatory               |  |                                                                | 0       |  |                                                                     |  | 60,000 |                                                                                        |  |  |                        |  |  | $                    | 13.50 |  |                                                       |  | 01/08/2019 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 13,750  |  |                                                                     |  | 41,250 |                                                                                        |  |  |                        |  |  | $                    | 9.99  |  |                                                       |  | 06/13/2018 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 5,000   |  |                                                                     |  | 15,000 |                                                                                        |  |  |                        |  |  | $                    | 9.96  |  |                                                       |  | 01/11/2018 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 7,000   |  |                                                                     |  | 7,000  |                                                                                        |  |  |                        |  |  | $                    | 13.97 |  |                                                       |  | 06/15/2017 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 
|                             |  |                                                                | 50,000  |  |                                                                     |  | 50,000 |                                                                                        |  |  |                        |  |  | $                    | 15.08 |  |                                                       |  | 04/30/2017 |                                                               |  |  |                                                                                            |  |  |                                                                                                               |  |  |  |  |  |  |  |  |  | 



|(1) | Option awards vest as follows:
|--- | ------------------------------



| | (a) | Grants with expiration dates in the years 2010, 2011, 2012, 2013, 2014 and 2015 are fully vested.
| | --- | -------------------------------------------------------------------------------------------------



| | (b) | All other grants vest one-fourth on the first anniversary of the date of grant, one-fourth on the second anniversary of the date of grant, one-fourth on the third
anniversary of the date of grant and one-fourth on the fourth anniversary of the date of grant. Grants with expiration dates in 2016 are 75% vested, grants with expiration dates in 2017 are 50% vested, grants with expiration dates in 2018 are 25%
vested and grants with expiration dates in years after 2018 have not vested at all.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (c) | All option awards have a term of 10 years.
| | --- | ------------------------------------------



33



---

##### Table of Contents

Option Exercises And Stock Vested



|                                  |                                          |               |        |                               |              |   |                                         |  |  |                              |   |  |  |  |   | 
|--------------------------------- | ---------------------------------------- | ------------- | ------ | ----------------------------- | ------------ | - | --------------------------------------- |  |  | ---------------------------- | - |  |  |  | - | 
|Name and Principal Position       |                                          | Option Awards |        |                               | Stock Awards |  
|                                  | Number of SharesAcquired on Exercise (#) |               |        | Value Realized onExercise ($) |              |   | Number of SharesAcquired on Vesting (#) |  |  | Value Realizedon Vesting ($) |  
|Vincent J. Milano,                |                                          |               | 22,500 |                               |              | $ | 42,187.50                               |  |  |                              |  |  |  |  |  | 
|Chief Executive Officer           |                                          |               |        |                               |              |   |                                         |  |  |                              |   |  |  |  |   | 
|Charles A. Rowland,               |                                          |               |       |                               |              |   |                                        |  |  |                              |  |  |  |  |  | 
|VP, Chief Financial Officer       |                                          |               |        |                               |              |   |                                         |  |  |                              |   |  |  |  |   | 
|Colin Broom,                      |                                          |               |       |                               |              |   |                                        |  |  |                              |  |  |  |  |  | 
|VP, Chief Scientific Officer      |                                          |               |        |                               |              |   |                                         |  |  |                              |   |  |  |  |   | 
|Thomas F. Doyle,                  |                                          |               | 22,500 |                               |              | $ | 42,187.50                               |  |  |                              |  |  |  |  |  | 
|VP, Strategic Initiatives         |                                          |               |        |                               |              |   |                                         |  |  |                              |   |  |  |  |   | 
|Daniel Soland,                    |                                          |               |       |                               |              |   |                                        |  |  |                              |  |  |  |  |  | 
|VP, Chief Operating Officer       |                                          |               |        |                               |              |   |                                         |  |  |                              |   |  |  |  |   | 
|Robert Pietrusko                  |                                          |               |       |                               |              |   |                                        |  |  |                              |  |  |  |  |  | 
|VP, Global Quality and Regulatory |                                          |               |        |                               |              |   |                                         |  |  |                              |   |  |  |  |   | 

2009 Potential Payments Upon Termination Or Change of Control

Agreements with our Named Executive Officers

In this section, we describe payments that may be made to our named executive officers upon several events of termination, including termination in connection with a change of control. The payment amounts
discussed and in the table below reflect the payments that would have been due to the named executive officers had the termination or change of control event occurred on December 31, 2009. The information in this section does not include
information relating to payments and benefits provided on a nondiscriminatory basis to salaried employees generally upon termination of employment. On December 31, 2009, the last reported sale price of our common stock on the NASDAQ Stock
Market was $8.39 per share. Actual amounts payable would vary based on the date of the named executive officers termination of employment and can only be finally determined at that time.

We have entered into change of control agreements with each of our named executive officers. If a named executive officer is terminated
(i) by the company without cause, (ii) on account of the named executive officers death or disability, or (iii) by the named executive officer for good reason, within 24 months after a change of control or 90 days prior to a
change of control, then the employee will be entitled to the following severance payments or benefits:



| |  |  | A lump sum payment equal to 200% of a named executive officers base salary in effect at the time of termination.
| | - |  | -----------------------------------------------------------------------------------------------------------------



| |  |  | A lump sum payment equal to two times a named executive officers target bonus in effect at the time of termination, assuming 100% of the target
bonus amount is paid.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | For a period of 18 months commencing from the date of termination, the company will waive all applicable premiums due for the company portion of the
group health continuation coverage elected by the named executive officer and their dependents (if applicable) under COBRA.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Any of the following situations would constitute a change of control under the change of control agreements:



| |  |  | a dissolution or liquidation of us;
| | - |  | -----------------------------------



| |  |  | a sale or otherwise disposition of all or substantially all of our assets;
| | - |  | --------------------------------------------------------------------------



| |  |  | a merger or consolidation where more than 50% of the combined voting power of our outstanding securities is transferred;
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | the acquisition by any person or entity of the beneficial ownership of securities representing 50% or more of the combined voting power of our then
outstanding voting securities unless certain procedures have occurred; or
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | a change in the composition of our board of directors over a period of twelve months or less such that a majority of the board members ceases to be
comprised of individuals who either (i) have been board members continuously since the beginning of such period, or (ii) have been elected or nominated for election as board members during such period by at least a 60% majority of the
board members described in clause (i) who were still in office at the time such election or nomination was approved by the board.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

A termination of a named executive officer for cause will not trigger any severance liability to a named executive officer under the change of control agreement. Cause is when an
employee has engaged in any act of fraud, embezzlement, or any other serious criminal conduct that adversely affects the company, committed intentionally by the employee in connection with employees employment or the conviction, or plea of
guilty or nolo contendere to, any felony.

For our named executive officers, a resignation for Good Reason
includes: (i) a material diminution in the employees authority, duties or responsibilities; (ii) a change in the location of the facility at which employee is required to perform his or her duties is more than 50 miles from Exton,
Pennsylvania, unless such new location does not increase the employees commuting time; (iii) a reduction of five percent (5%) or more in either of the employees base salary or the amount of the employees target bonus; or
(iv) our failure to pay or make available any material payment or benefit due under the agreement or any other material breach by us of the agreement.



34



---

##### Table of Contents

However, the above events or conditions will constitute Good Reason only if (i) such
event or condition occurs during the period beginning 90 days immediately preceding a Change of Control and ending 24 months thereafter and (ii) the employee provides the company with written objection to the event or condition within 60 days
following the occurrence thereof, the company does not reverse or otherwise cure the event or condition within 30 days of receiving that written objection and the employee resigns employees employment within 90 days following the expiration of
that cure period.

The foregoing severance payments and benefits payable upon termination of employment to each named
executive officer are conditioned on the execution of a written release and non-disparagement agreement. In addition, all of our named executive officers are bound by restrictive covenant which are a condition of the severance payments and benefits.
Specifically, during the term of each executives employment with us and for a period of one year beginning on the later of (i) termination of employment or (ii) the date of the change of control, each named executive officer is bound
by non-competition and non-solicitation restrictive covenants.

In the event any severance payments or benefits to our named
executive officers would constitute an excess parachute payment within the meaning of section 280G of the Code and be subject to the excise tax imposed by section 4999 of the Code, the affected named executive officers will be
entitled to the greater of (on a net after-tax basis including the excise tax): (i) the largest amount of the payment that would result in no portion of the payment or benefit being subject to the excise tax under section 4999 of the Code,
or (ii) the entire payment or benefit without any reduction to avoid the excise tax.

In July 2002, we adopted the
ViroPharma Incorporated Severance Pay Plan, which is intended to provide separation benefits to certain of our employees in the event that they are separated from employment involuntarily. The Severance Pay Plan is administered by the compensation
committee of our board of directors. In general, any person who is regularly employed by us for 30 or more hours per week is eligible for salary continuation and COBRA continuation coverage in an amount that is determined by the administrator, in
its sole discretion, prior to an employees separation from employment. In exchange for these benefits, the employee will release us from any obligations we may have incurred in connection with the employees employment with us.

The following table summarizes the amounts payable to each of our named executive officers based on the items described above
with respect to each of the events set forth in the table.



|                        |  |                                        |  |                                                                                                                                       |           | 
|----------------------- |  | -------------------------------------- |  | ------------------------------------------------------------------------------------------------------------------------------------- | --------- | 
|Named Executive Officer |  | Benefits                               |  | Involuntary Termination without Cause,Termination Due to Death or Disability,or For
Good Reasonin Connection with a Change of Control |          
|Vincent J. Milano       |  | Cash Severance(1)                      |  | $                                                                                                                                     | 1,500,000 | 
|                        |  | Continued Welfare(2)                   |  | $                                                                                                                                     | 34,782    | 
|                        |  | Acceleration Value of Stock
Options(3) |  | $                                                                                                                                     | 138,880   | 
|                        |  | Gross-Up Payment(6)                    |  | $                                                                                                                                     | 0         | 
|                        |  |                                        |  |                                                                                                                                       |           | 
|                        |  | Total Value                            |  | $                                                                                                                                     | 1,673,662 | 
|Charles A. Rowland      |  | Cash Severance(1)                      |  | $                                                                                                                                     | 1,020,000 | 
|                        |  | Continued Welfare(2)                   |  | $                                                                                                                                     | 34,782    | 
|                        |  | Acceleration Value of Stock
Options(4) |  | $                                                                                                                                     | 99,200    | 
|                        |  | Gross-Up Payment(6)                    |  | $                                                                                                                                     | 0         | 
|                        |  |                                        |  |                                                                                                                                       |           | 
|                        |  | Total Value                            |  | $                                                                                                                                     | 1,153,982 | 
|Colin Broom             |  | Cash Severance(1)                      |  | $                                                                                                                                     | 1,065,000 | 
|                        |  | Continued Welfare(2)                   |  | $                                                                                                                                     | 34,782    | 
|                        |  | Acceleration Value of Stock
Options(4) |  | $                                                                                                                                     | 99,200    | 
|                        |  | Gross-Up Payment(6)                    |  | $                                                                                                                                     | 0         | 
|                        |  |                                        |  |                                                                                                                                       |           | 
|                        |  | Total Value                            |  | $                                                                                                                                     | 1,198,982 | 



35



---

##### Table of Contents



|                 |  |                                        |  |   |           | 
|---------------- |  | -------------------------------------- |  | - | --------- | 
|Thomas F. Doyle  |  | Cash Severance(1)                      |  | $ | 990,000   | 
|                 |  | Continued Welfare(2)                   |  | $ | 34,782    | 
|                 |  | Acceleration Value of Stock Options(4) |  | $ | 99,200    | 
|                 |  | Gross-Up Payment (6)                   |  | $ | 0         | 
|                 |  |                                        |  |   |           | 
|                 |  | Total Value                            |  | $ | 1,123,982 | 
|Daniel Soland    |  | Cash Severance(1)                      |  | $ | 1,095,000 | 
|                 |  | Continued Welfare(2)                   |  | $ | 34,782    | 
|                 |  | Acceleration Value of Stock Options(5) |  | $ | 136,400   | 
|                 |  | Gross-Up Payment(6)                    |  | $ | 0         | 
|                 |  |                                        |  |   |           | 
|                 |  | Total Value                            |  | $ | 1,266,182 | 
|Robert Pietrusko |  | Cash Severance(1)                      |  | $ | 1,120,000 | 
|                 |  | Continued Welfare(2)                   |  | $ | 34,782    | 
|                 |  | Acceleration Value of Stock Options(4) |  | $ | 99,200    | 
|                 |  | Gross-Up Payment(6)                    |  | $ | 0         | 
|                 |  |                                        |  |   |           | 
|                 |  | Total Value                            |  | $ | 1,253,982 | 



|(1) | This amount is equal to (i) 200% of base salary, plus (ii) two times the target bonus, assuming 100% of the target bonus is paid, for each named executive
officer as in effect on December 31, 2009.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | This amount is equal to COBRA continuation coverage based on 102% of the monthly medical costs for family coverage under our Personal Choice 20 Medical Plan, such
amount being $1,932.35, multiplied by 18 months.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | This amount represents the value of unvested stock options to purchase an aggregate of 56,000 shares of common stock, based on the difference between the exercise price
of the options and $8.39, the closing price of our common stock on December 31, 2009. The actual value realized will vary depending on the date the options are exercised.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(4) | This amount represents the value of unvested stock options to purchase an aggregate of 40,000 shares of common stock, based on the difference between the exercise price
of the options and $8.39, the closing price of our common stock on December 31, 2009. The actual value realized will vary depending on the date the options are exercised.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(5) | This amount represents the value of unvested stock options to purchase an aggregate of 55,000 shares of common stock, based on the difference between the exercise price
of the options and $8.39, the closing price of our common stock on December 31, 2009. The actual value realized will vary depending on the date the options are exercised.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | None of our named executive officers are entitled to gross up payments. In the event any severance payments or benefits to our named executive officers
would constitute an excess parachute payment within the meaning of section 280G of the Code and be subject to the excise tax imposed by section 4999 of the Code, the affected named executive officers will be entitled to the greater
of (on a net after-tax basis including the excise tax): (i) the largest amount of the payment that would result in no portion of the payment or benefit being subject to the excise tax under section 4999 of the Code, or (ii) the entire
payment or benefit without any reduction to avoid the excise tax. Based on the analysis conducted as of December 31, 2009, the total payments for Messrs. Pietrusko, Rowland and Soland would be subject to an excise tax. Mr. Soland would be
in a better net after-tax position by reducing his payments to avoid the excise tax under section 4999 of the Code, such reduced amount being $1,016,620. Dr. Pietrusko and Mr. Rowland would not be in a better net after-tax position by
reducing their payments.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Confidentiality and Inventions Agreements

We have entered into confidentiality and inventions agreements with each of our employees. The agreements provide that, among other
things, all inventions, discoveries and ideas made or conceived by an employee during employment which are useful to us or related to our business or which were made or conceived with the use of our time, material, facilities or trade secret
information, belong exclusively to us, without additional compensation to the employee. The agreements also have confidentiality provisions in favor of us and noncompetition provisions in favor of us during employment.



36



---

##### Table of Contents

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

The current members of the compensation committee are Mr. Glaser and Dr. Claypool. Neither of these individuals were at any
time during fiscal year 2009 an officer or employee of ours or has any relationship that is required to be disclosed pursuant to the rules of the Securities and Exchange Commission. Furthermore, none of our executive officers serves on the board of
directors or compensation committee of any entity that has an executive officer serving as a member of our board of directors or compensation committee.

TRANSACTIONS WITH RELATED PERSONS, PROMOTERS AND CERTAIN

CONTROL PERSONS

Transactions with Related Persons

Since January 1, 2009, there were not any transactions, nor are there currently any proposed transactions, in which we were or are to be a participant and the amount involved exceeds $120,000, and in
which any related person had or will have a direct or indirect material interest.

Review, Approval or Ratification of Transactions with
Related Persons

The audit committee of our board of directors is responsible for reviewing and recommending action to the
board of directors regarding potential material transactions with related persons, including any of our directors or executive officers, certain of our stockholders and their immediate family members. This obligation is set forth in writing in our
Audit Committee Charter, a copy of which is available on our Internet website at www.viropharma.com.

To identify
related party transactions, each year, we require our directors and officers to complete director and officer questionnaires identifying any transactions with us in which the officer or director or their family members have an interest. We review
related party transactions due to the potential for a conflict of interest. A conflict of interest occurs when an individuals private interest interferes, or appears to interfere, in any way with our interests or the interests of our
stockholders. Our Code of Business Conduct and Ethics requires all directors, officers and employees who may have a potential or apparent conflict of interest to immediately notify our General Counsel.

We expect our directors, officers and employees to act and make decisions that are in our best interests and encourage them to avoid
situations which present a conflict between our interests or the interests of our stockholders and their own personal interests. Our directors, officers and employees are prohibited from taking any action that may make it difficult for them to
perform their duties, responsibilities and services to us in an objective and fair manner.

A copy of our Code of Business
Conduct and Ethics is available on our Internet website at www.viropharma.comby selecting Investors and then Corporate Governance.



37



---

##### Table of Contents

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this
report to be signed on our behalf by the undersigned, thereunto duly authorized.



VIROPHARMA INCORPORATEDBy:

/s/     VINCENT J.
MILANOVincent J. Milano President, Chief Executive Officer


Pursuant to
the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated:



|                                |  |                                                                        |  |      |                  | 
|------------------------------- |  | ---------------------------------------------------------------------- |  | ---- | ---------------- | 
|Name                            |  | Capacity                                                               |  | Date |                 
|                                |  |                                                                       
|/S/     VINCENT J.
MILANO       |  | President, Chief Executive Officer (Principal Executive Officer)       |  |      | December 3, 2010 | 
|Vincent J. Milano               |  |                                                                        |  |      |                 
|                                |  |                                                                       
|/S/     CHARLES A.
ROWLAND, JR. |  | Chief Financial Officer (Principal Financial Officer)                  |  |      | December 3, 2010 | 
|Charles A. Rowland, Jr.         |  |                                                                        |  |      |                 
|                                |  |                                                                       
|/S/     RICHARD S.
MORRIS       |  | Chief Accounting Officer and Controller (Principal Accounting Officer) |  |      | December 3, 2010 | 
|Richard S. Morris               |  |                                                                        |  |      |                 
|                                |  |                                                                       
|/S/     VINCENT J.
MILANO       |  | Chairman of the Board                                                  |  |      | December 3, 2010 | 
|Vincent J. Milano               |  |                                                                        |  |      |                 
|                                |  |                                                                       
|*                               |  | Director                                                               |  |      | December 3, 2010 | 
|Paul A. Brooke                  |  |                                                                        |  |      |                 
|                                |  |                                                                       
|*                               |  | Director                                                               |  |      | December 3, 2010 | 
|William Claypool, M.D.          |  |                                                                        |  |      |                 
|                                |  |                                                                       
|*                               |  | Director                                                               |  |      | December 3, 2010 | 
|Michael R. Dougherty            |  |                                                                        |  |      |                 
|                                |  |                                                                       
|*                               |  | Director                                                               |  |      | December 3, 2010 | 
|Robert J. Glaser                |  |                                                                        |  |      |                 
|                                |  |                                                                       
|*                               |  | Director                                                               |  |      | December 3, 2010 | 
|John R. Leone                   |  |                                                                        |  |      |                 
|                                |  |                                                                       
|*                               |  | Director                                                               |  |      | December 3, 2010 | 
|Howard H. Pien                  |  |                                                                        |  |      |                 
|                                |  |                                                                       
|*                               |  | Director                                                               |  |      | December 3, 2010 | 
|Frank Baldino, Jr.              |  |                                                                        |  |      |                 



38



---

##### Table of Contents

By signature set forth below, the undersigned, pursuant to the duly authorized powers of
attorney filed with the Securities and Exchange Commission, has signed this amendment no. 1 to annual report on Form 10-K/A on behalf of the persons indicated.



|     |  |                                                     
|---- |  | ----------------------------------------------------
|*By: |  | /s/     VINCENT J.
MILANO                           
|     |  | Vincent J. Milano President, Chief Executive Officer



39