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SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

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FORM 10-K

(Mark One)

|  |  |                                                                                      |  | 
|- |  | ------------------------------------------------------------------------------------ |  | 
|x |  | Annual report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 |  | 

For the fiscal year ended December 31, 2005

OR

|  |  |                                                                                          |  | 
|- |  | ---------------------------------------------------------------------------------------- |  | 
| ̈ |  | Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 |  | 

For the transition period
from                    to

Commission File Number: 0-21699

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VIROPHARMA INCORPORATED

(Exact name
of registrant as specified in our charter)

|                                                                        |  |                                                
|----------------------------------------------------------------------- |  | -----------------------------------------------
|Delaware (State or other jurisdiction of incorporation or organization) |  | 23-2789550 (I.R.S. Employer Identification No.)
|397 Eagleview Boulevard, Exton, Pennsylvania                            |  | 19341 (Zip Code)                               
|(Address of principal executive offices)                                |  |                                                

Registrants telephone number, including area code: 610-458-7300

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Securities registered pursuant to Section 12(b) of the Act:

|                          |  |                                                
|------------------------- |  | -----------------------------------------------
|Title of each class: None |  | Name of each exchange on which registered: None

Securities registered pursuant to Section 12(g) of the Act:

Common Stock, par value $0.002

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Indicate by check mark if the registrant is a well-known seasoned issuer, as defined by Rule 405 of the Securities Act.  Yes  x  No ̈



Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d)
of the Exchange Act.  Yes ̈No  x



Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports) and (2) has been subject to such filing
requirements for the past 90 days.  Yes  x  No ̈



Indicate by check mark if disclosure of delinquent filers pursuant to
Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to
this Form 10-K. ̈



Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of
accelerated filer and large accelerated filer in Rule 12b-2 of the Exchange Act. (Check one):

|                         |  |                     |  |                       
|------------------------ |  | ------------------- |  | ----------------------
|Large Accelerated Filer ̈ |  | Accelerated Filer x |  | Non-accelerated filer ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of
the Exchange Act).  Yes ̈No  x



The approximate aggregate market value of the voting stock held by
non-affiliates of the registrant was approximately $324.0 million as of June 30, 2005, based upon the closing sale price per share of the Common Stock as quoted on the Nasdaq National Market on that date.



The number of shares of the registrants Common Stock outstanding as of
February 24, 2006 was 68,585,108 shares.

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DOCUMENTS INCORPORATED BY REFERENCE



As stated in Part III of this Annual Report on Form 10-K,
portions of the registrants definitive proxy statement for the registrants 2006 Annual Meeting of Stockholders to be held on May 19, 2006 are incorporated by reference in Part III of this Annual Report on Form 10-K.



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VIROPHARMA INCORPORATED



FORM 10-K ANNUAL REPORT

For Fiscal Year Ended December 31, 2005



TABLE OF CONTENTS



|                                            |  |                                                                                                              |  |     
|------------------------------------------- |  | ------------------------------------------------------------------------------------------------------------ |  | ----
|                                            |  |                                                                                                              |  | Page
|PART I                                      |  |                                                                                                              |  |     
|                                            |  |                                                                                                             
|Item 1.                                     |  | Business                                                                                                     |  | 1   
|Item 1A.                                    |  | Risk Factors                                                                                                 |  | 16  
|Item 1B.                                    |  | Unresolved Staff Comments                                                                                    |  | 34  
|Item 2.                                     |  | Properties                                                                                                   |  | 34  
|Item 3.                                     |  | Legal Proceedings                                                                                            |  | 34  
|Item 4.                                     |  | Submission of Matters to a Vote of Security Holders                                                          |  | 34  
|                                            |  |                                                                                                             
|PART II                                     |  |                                                                                                              |  |     
|                                            |  |                                                                                                             
|Item 5.                                     |  | Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities |  | 35  
|Item 6.                                     |  | Selected Financial Data                                                                                      |  | 36  
|Item 7.                                     |  | Managements Discussion and Analysis of Financial Condition and Results of Operation                         |  | 37  
|Item 7A.                                    |  | Quantitative and Qualitative Disclosures about Market Risk                                                   |  | 57  
|Item 8.                                     |  | Financial Statements and Supplementary Data                                                                  |  | 58  
|Item 9.                                     |  | Changes in and Disagreements with Accountants on Accounting and Financial Disclosure                         |  | 58  
|Item 9A.                                    |  | Control and Procedures                                                                                       |  | 58  
|Item 9B.                                    |  | Other Information                                                                                            |  | 61  
|                                            |  |                                                                                                             
|PART III                                    |  |                                                                                                              |  |     
|                                            |  |                                                                                                             
|Item 10.                                    |  | Directors and Executive Officers of the Registrant                                                           |  | 62  
|Item 11.                                    |  | Executive Compensation                                                                                       |  | 62  
|Item 12.                                    |  | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters               |  | 62  
|Item 13.                                    |  | Certain Relationships and Related Transactions                                                               |  | 62  
|Item 14.                                    |  | Principal Accounting Fees and Services                                                                       |  | 62  
|                                            |  |                                                                                                             
|PART IV                                     |  |                                                                                                              |  |     
|                                            |  |                                                                                                             
|Item 15.                                    |  | Exhibits and Financial Statement Schedules                                                                   |  | 63  
|                                            | 
|Signatures                                  |  | 67                                                                                                          
|                                            | 
|Index to Financial Statements and Schedules |  | 68                                                                                                          



ViroPharma, ViroPharma plus the design, and Vancocin are trademarks and service marks of ViroPharma or its licensors. We have obtained trademark registration in the United States for the marks in
connection with certain products and services. All other brand names or trademarks appearing in this Annual Report on Form 10-K are the property of others.



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PART I



|ITEM 1. | BUSINESS
|------- | --------



We are a biopharmaceutical company dedicated to the development and commercialization of products that address serious diseases. We have a core expertise
in the area of infectious diseases and are committed to focusing our commercialization and development programs on products used by physician specialists or in hospital settings. We intend to grow through sales of our marketed product, Vancocin® capsules HCl, and through the continued development of
our product pipeline and potential acquisition of products or companies.



We have one marketed product and multiple product candidates in clinical development. We market and sell Vancocin capsules HCl, the oral capsule formulation of vancomycin hydrochloride, in the United States and its
territories. Vancocin is a potent antibiotic approved by the U.S. Food and Drug Administration, or FDA, to treat antibiotic-associated pseudomembranous colitis caused by Clostridium difficile, or C. difficile, and enterocolitis caused
by Staphylococcus aureus, or S. aureus, including methicillin-resistant strains. We are developing maribavir for the treatment of cytomegalovirus, or CMV, infection, and HCV-796 for the treatment of hepatitis C virus, or HCV,
infection. We have licensed the U.S. and Canadian rights for a third product candidate, an intranasal formulation of pleconaril, to Schering-Plough for the treatment of picornavirus infections.



We intend to continue to evaluate in-licensing or other means of acquiring
products in clinical development, and marketed products, in order to expand our current portfolio. Such products may be intended to treat, or are currently used to treat, the patient populations treated by physician specialists or in hospital
settings.



We were incorporated in Delaware in September 1994
and commenced operations in December 1994. Our executive offices are located at 397 Eagleview Boulevard, Exton, PA 19341, our telephone number is 610-458-7300 and our website address is www.viropharma.com. Information contained on our website is not
incorporated into this Annual Report on Form 10-K.



Vancocin Capsules



In November 2004, we acquired all rights in the U.S. and
its territories to manufacture, market and sell Vancocin, as well as rights to certain related vancomycin products, from Eli Lilly and Company (Lilly) for a $116 million upfront payment and additional purchase price consideration based
on pre-defined sales levels through 2011. Lilly retained its rights to Vancocin outside of the U.S. and its territories.



C. difficile is a bacterium that produces toxins in the lower gastrointestinal, or GI, tract which can cause inflammation of the colon, severe
diarrhea and occasionally death. The bacterium typically colonizes the GI tract during or after therapy with antibiotics, as these antibiotics reduce competition by other bacteria, allowing C. difficile to proliferate. Hospitalized
patients, particularly the elderly who have been treated with broad spectrum antibiotics, are at greatest risk of acquiring diseases related to C. difficile infection. C. difficile-associated disease, or CDAD, is an infection of the
lining of the large bowel, which usually manifests as a severe form of diarrhea and is one of the most common hospital-acquired, or nosocomial, infections.



It is extremely difficult to estimate with precision actual CDAD incidence. This is due to a number of factors, including that CDAD is not a CDC (U.S.
Centers for Disease Control) reportable disease and is often not the primary reason that CDAD patients are admitted to hospitals. Nonetheless, experts within the infectious disease medical community have observed that the incidence and severity of
CDAD have been increasing. We estimate that during 2005, CDAD affected over 400,000 patients in the U.S. Over the past two years, many states and medical societies have reported increased rates of CDAD and observed a higher incidence of more severe
disease and associated increase in mortality. In addition, a significant concern expressed by clinicians has been the rapid progression observed in some patients to more severe and sometimes fatal disease.



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The CDC postulates on its website that the increased rates of CDAD and severity of disease may be caused
by a combination of three factors: changes in antibiotic use, changes in infection control practices and the emergence of a new strain of C. difficile characterized by increased virulence as well as potential antimicrobial resistance. This
new epidemic strain of C. difficile is often referred to as toxinotype-III or the BI strain. This strain has been reported in at least 16 states in the U.S., according to the CDC.



Vancocin is the only drug approved by the FDA for the treatment of antibiotic-associated pseudomembranous colitis, a disease
caused by C. difficile infections. Historically, a generic compound called metronidazole has typically been used as first-line treatment for CDAD, while Vancocin has been reserved by physicians for patients who have failed metronidazole
therapy, who have relapsed or who are suffering from severe forms of CDAD. We believe that the epidemiological shift that has contributed to increased incidence and severity of CDAD has led to an increase in the use of Vancocin.



Product Pipeline



We have three product development programs. We have two active programs that target: (1) CMV with an initial focus on
CMV infections in recipients of hematopoietic stem cell / bone marrow transplants, and (2) HCV. These programs are within the transplant and hospital settings or focus on diseases treated by hepatologists and gastroenterologists, and are at the
center of our strategic focus. Our third program has been licensed to Schering-Plough and targets picornaviruses with intranasal pleconaril.



The following chart generally describes our clinical development programs:



|                      |  |                                          |  |                    |  |                                                     
|--------------------- |  | ---------------------------------------- |  | ------------------ |  | ----------------------------------------------------
|Product Candidate     |  | Program Indication                       |  | Development Status |  | ViroPharma Commercialization Rights                 
|Maribavir             |  | CMV infection                            |  | Phase 2            |  | Worldwide, other than Japan                         
|                      |  |                                          | 
|HCV-796               |  | HCV infection                            |  | Phase 1b           |  | Co-promotion rights inthe U.S. and Canada with Wyeth
|                      |  |                                          | 
|Intranasal pleconaril |  | Common cold and     asthma exacerbations |  | Phase 2            |  | Licensed to Schering-Plough                         



CMV Program



As of December 31, 2005, we have completed four Phase 1 clinical trials
with maribavir to evaluate the potential for drug interactions and to evaluate the pharmacokinetics of maribavir in subjects with renal impairment and in subjects with hepatic impairment. We have completed dosing in a Phase 1 clinical trial to
evaluate the relative bioavailability of different tablet formulations. A Phase 2 clinical trial with maribavir for the prevention of CMV infections in allogeneic stem cell transplant patients, which was initiated in mid-2004, was fully enrolled as
of November 2005, and we expect to have preliminary data from our Phase 2 clinical trial by the end of the first quarter of 2006. If these data are supportive, we plan to initiate Phase 3 clinical trials.



CMV is a member of the herpes virus group, which includes the viruses that
cause chicken pox, mononucleosis, herpes labialis (cold sores) and genitalis (genital herpes). Like other herpes viruses, CMV has the ability to remain dormant in the body for long periods of time. CMV infection rates average between 50% and 85% of
adults in the U.S. by 40 years of age. In most individuals with intact immune systems, CMV causes little to no apparent illness. However, in immunocompromised individuals, CMV can lead to serious disease or death. Currently, patients who are
immunosuppressed following hematopoietic stem cell/bone marrow or solid organ transplantation remain at high risk of CMV infection. In these patients, CMV can lead to severe conditions such



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as pneumonitis or hepatitis, or to complications such as acute or chronic rejection of a transplanted organ, or even death. There are approximately 19,000
autologous and allogeneic stem cell / bone marrow transplant patients in North America, and 26,000 solid organ transplant patients in the U.S. on an annual basis who are at increased risk of serious repercussions from infection.



HCV Program



In the first quarter of 2005, we, with our partner Wyeth, completed a Phase 1 clinical trial with HCV-796 in healthy
subjects. In November 2005, we announced the preliminary results of a Phase 1b proof of concept dose ranging clinical trial with HCV-796 in hepatitis C infected patients. Our Phase 1b trial was a randomized, double blind, multiple ascending dose,
placebo-controlled study at a leading clinical research facility in the U.S. involving patients with chronic HCV infection who were näive to treatment. Seventy-two percent of all patients in the study were infected with HCV genotype 1. Trial
participants were given twice-daily administration of 50, 100, 250, 500, 1000, or 1500 mg oral doses of HCV-796 or placebo for fourteen days. The study assessed the safety, antiviral activity, and pharmacokinetic profile of the drug compared to
placebo.



In this study, HCV-796 was generally well tolerated
across the treatment groups, and no dose-limiting toxicity was identified. Mild to moderate headache was the most frequent adverse event reported overall. There were no treatment-emergent serious adverse events.



HCV-796 drug levels increased less than proportionally with increasing dose,
and appeared to reach a plateau at the 1000 mg cohort. Through the first five cohorts, dose related responses to HCV-796 as measured by reduction in plasma HCV RNA levels from baseline were observed. In the 1000 mg cohort, the peak mean reduction in
HCV RNA from baseline was 1.4 log 10 (96 percent) on day four, 1.3 log 10 (95 percent) on day seven, and 0.7 log 10 (80 percent) on day 14. The 500 mg cohort showed similar results. In this group, the mean reduction in HCV RNA was 1.4 log 10 on day
four, 1.1 log 10 on day seven, and 0.4 log 10 on day 14. Viral reduction curves were of a similar pattern across all cohorts. For patients receiving placebo, mean plasma HCV RNA increased 0.1 log 10 compared to baseline on day four, and was
unchanged from baseline on day 14. Antiviral activity appeared similar among patients infected with HCV genotype 1 compared to those with non-genotype 1 infection, although fewer subjects in the trial were infected with non-genotype 1 HCV.
Additional analyses from HCV-796 studies, including the effect of food on absorption, pharmacodynamic/pharmacokinetic correlations, and viral genetic sequencing, are currently being conducted.



We and Wyeth have initiated studies to assess the antiviral activity,
pharmacokinetics and tolerability of HCV-796 in combination with pegylated interferon. These data are expected in the second quarter of 2006. If these data are supportive, we and Wyeth will determine the next steps, including progression to a Phase
2 study.



Hepatitis is an inflammation of the liver that is
often caused by viruses, such as hepatitis A, B, or C. Hepatitis C virus is recognized as a major cause of chronic hepatitis worldwide. According to the CDC and the World Health Organization, about 4 million Americans and 170 million
people, worldwide, respectively, are infected with HCV. The acute stage, which occurs 2 weeks to 6 months after infection, usually is so mild that most people do not know they have been infected. About 75% of people who are newly infected with HCV
progress to develop chronic infection. Liver damage (cirrhosis) develops in about 10% to 20% of persons with chronic infection, and liver cancer develops in 1% to 5% of persons with chronic infection over a period of 20 to 30 years. Liver damage
caused by HCV infection is the most common reason for liver transplantation in the U.S.



Common Cold and Asthma Exacerbations Program



Pleconaril is a proprietary, small molecule inhibitor of picornaviruses, which we licensed from Sanofi-Aventis. In preclinical studies, pleconaril has demonstrated the ability to inhibit picornavirus replication in vitro by a novel,
virus-specific mode of action. Pleconaril works by inhibiting the function of the viral protein coat, also known as the viral capsid, which is essential for virus infectivity and transmission. Preclinical studies have



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shown that pleconaril integrates within the picornavirus capsid at a specific site that is common to a majority of picornaviruses and disrupts several stages
of the virus infection cycle. In May 2002, the FDA issued a not-approvable letter in response to our new drug application for an oral formulation of pleconaril for the treatment of the common cold in adults. In contrast, the new
formulation of pleconaril is delivered intranasally.



In
November 2004, we entered into a license agreement with Schering-Plough under which Schering-Plough assumed responsibility for all future development and commercialization of pleconaril in the U.S. and Canada. Schering-Plough paid us an initial
license fee of $10.0 million in December 2004 and purchased our inventory of bulk drug substance for an additional $6.0 million in January 2005. We understand that Schering-Plough is planning to evaluate an intranasal formulation of pleconaril in
Phase 2 clinical trials.



Business Development



We intend to continue to evaluate in-licensing or other means of acquiring
products in clinical development, and marketed products, in order to expand our current portfolio. Such products may be intended to treat, or are currently used to treat, the patient populations treated by physician specialists or in hospital
settings.



Competition for products in clinical development, or
that are currently on the market, is intense and may require significant resources. There is no assurance that we will be successful in acquiring such products, or that such products can be acquired on terms acceptable to us. Additionally, if we are
successful in acquiring a marketed product, we may have to expand our marketing team and build a sales force. There is no assurance that we would be successful in expanding our commercial capabilities, that we would be able to penetrate the markets
for any such products or that we could achieve market acceptance of our products.



Strategic Relationships



Vancocin Capsules and Lilly



In November 2004, we acquired all rights in the U.S. and
its territories to manufacture, market and sell Vancocin, the oral capsule formulation of vancomycin hydrochloride, as well as rights to certain related vancomycin products, from Lilly. Vancocin is a potent antibiotic approved by the FDA to treat
antibiotic-associated pseudomembranous colitis caused by C. difficile and enterocolitis caused by S. aureus, including methicillin-resistant strains. Lilly retained its rights to vancomycin outside of the U.S. and its territories.



We paid Lilly an upfront cash payment of $116.0 million.
During 2005, we were obligated to pay Lilly additional purchase price consideration equal to 50% of our net sales of Vancocin between $44 million and $65 million. We surpassed the maximum level of $65 million of net sales of Vancocin during 2005 and
paid Lilly additional consideration of $10.5 million. We will pay additional amounts based on annual net sales of Vancocin as set forth below:



|                  |  |                                                
|----------------- |  | -----------------------------------------------
|2006              |  | 35% payment on net sales between $46-65 million
|2007              |  | 35% payment on net sales between $48-65 million
|2008 through 2011 |  | 35% payment on net sales between $45-65 million



No additional payments
are due to Lilly on net sales of Vancocin below or above the net sales levels reflected in the above table. We will account for the future additional payments as contingent consideration and record an adjustment to the carrying amount of the related
intangible assets and a cumulative adjustment to the intangible amortization upon achievement of the related sales milestones. Assuming the maximum threshold is met at the end of each year, the cumulative amortization adjustment would be $0.6
million, $0.7 million and $1.2 million in the years ended December 31, 2006, 2007 and 2008, respectively. See Note 6 of the Consolidated Financial Statements for additional information on the intangible assets and amortization.



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In the event we develop any product line extensions, revive discontinued vancomycin product lines
(injectable or oral solutions), make improvements of existing products, or expand the label to cover new indications, Lilly would receive a royalty on net sales on these additional products for a predetermined time period.



In connection with the acquisition, we entered into a transition services
agreement with Lilly. The transition period ended in January 2005 when we assumed responsibility for product inventory, warehousing, management services and distribution of the Vancocin brand in the U.S. We also entered into a supply agreement with
Lilly for the manufacture and supply of the active pharmaceutical ingredient (API) of Vancocin as well as the Vancocin finished product for an agreed upon time period. In November 2005, we amended our manufacturing agreement with Lilly which, among
other things, increased the amount of Vancocin that Lilly supplied to us during 2005, for which we agreed to pay up to an additional $4.5 million, and ensured that Lilly continues to supply us with Vancocin until at least September 30, 2006.
That date will be extended to a later date if our third party supply chain is not qualified by September 30, 2006. The process of qualifying a third party supply chain is now ongoing. Lilly supplied the agreed upon increased product volume in
2005. The additional $4.5 million increased inventory costs and will increase our cost of sales for these specific units, which we expect to sell in the first half of 2006.



Cytomegalovirus and GlaxoSmithKline



In August 2003, we entered into a license agreement with GlaxoSmithKline (GSK) under which we acquired worldwide rights (excluding Japan) to
an antiviral compound, maribavir, for the treatment of CMV disease. Maribavir is a benzimidazole compound that was in development by GSK for the treatment of CMV retinitis in HIV positive patients. We initiated a dose-ranging Phase 2 clinical trial
with maribavir for the prevention of CMV infections in allogeneic stem cell / bone marrow transplant patients in July 2004.



Under the terms of the agreement, we have exclusive worldwide rights (excluding Japan) to develop and commercialize maribavir for the prevention and
treatment of cytomegalovirus infections related to transplant (including solid organ and hematopoietic stem cell / bone marrow transplantation), congenital transmission, and in patients with HIV infection. The patents covering maribavir expire in
2015. We paid GSK a $3.5 million up-front cash licensing fee and will pay additional milestone payments based upon defined clinical development and regulatory events. We also will pay royalties to GSK and its licensor on product sales in the U.S.
and rest of world (excluding Japan). We will be dependent on GSK to prosecute and maintain the patents related to maribavir, and to file any applications for patent term extension. We also may be dependent on GSK to protect such patent rights. We
have the right to sublicense our rights under the agreement, which under certain circumstances requires consent from GSK.



Hepatitis C and Wyeth



In December 1999, we entered into a collaboration and license agreement with Wyeth (formerly American Home Products Corporation) to jointly develop
products for use in treating hepatitis C due to the hepatitis C virus in humans. Under the agreement, we licensed to Wyeth worldwide rights under certain patents and know-how owned by us or created under the agreement. We have the right to
co-promote these products in the U.S. and Canada and Wyeth will promote the products elsewhere in the world. Wyeth has the right to manufacture any commercial products developed under the agreement.



In June 2003, we amended our collaboration agreement with Wyeth to, among
other things, focus the parties activity on one target, to allocate more of the collaborations pre-development efforts to us (subject to our cost sharing arrangement with Wyeth for this work), and to clarify certain of the reconciliation
and reimbursement provisions of the collaboration agreement. In addition, under the amended agreement both companies are permitted to work outside the collaboration on screening against targets other than the target being addressed together under
the collaboration. In connection with our restructuring in January 2004, we agreed with



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Wyeth to cease screening compounds against HCV under the collaboration. During the term of the agreement, the two parties will work exclusively with each
other on any promising compounds against the collaborations HCV target.



Wyeth paid us $5.0 million on the effective date of the original agreement, and is obligated to make milestone payments to us, and purchase additional shares of our common stock at a premium to the market price, upon
the achievement of certain development milestones. Through December 31, 2005, Wyeth has purchased an aggregate of 200,993 shares of our common stock for $6.0 million upon the achievement of two milestones. The remaining milestone events
generally include successful completion of steps in the clinical development of an HCV product and the submission for, and receipt of, marketing approval for the product in the U.S. and abroad. These milestones, however, may never be attained. Wyeth
will provide significant financial support for the development of HCV therapeutic compounds developed under the agreement.



Until the expiration or termination of the agreement, any profits from the sale of products developed under the agreement and sold in the U.S. and Canada
will be shared equally between us and Wyeth, subject to adjustment under certain circumstances. For sales of these products outside the U.S. and Canada, Wyeth will make royalty payments to us. These royalty payments will be reduced upon the
expiration of the last of our patents covering those products.



Our agreement with Wyeth terminates, country-by-country, in the U.S. and Canada, if the parties are no longer co-promoting any product developed under the agreement, and outside the U.S. and Canada, when Wyeth is no longer obligated to pay
us royalties on sales of products developed under the agreement.



Picornaviruses and Schering-Plough



In
November 2004, we entered into a license agreement with Schering-Plough under which Schering-Plough has assumed responsibility for all future development and commercialization of pleconaril in the U.S. and Canada. Schering-Plough paid us an upfront
option fee of $3.0 million in November 2003. In August 2004, Schering-Plough exercised its option to enter into a full license agreement with us following its assessment of the products performance in characterization studies. Schering-Plough
paid us an initial license fee of $10.0 million in December 2004 and purchased our inventory of bulk drug substance for an additional $6.0 million in January 2005. We are also eligible to receive up to an additional $65.0 million in milestone
payments upon achievement of certain targeted regulatory and commercial events, as well as royalties on Schering-Ploughs sales of intranasal pleconaril in the licensed territories. Schering-Plough is now responsible for the development and
commercialization of the intranasal formulation of pleconaril for the treatment of the common cold. Sanofi-Aventis has exclusive rights to market and sell pleconaril in countries other than the U.S. and Canada.



Picornaviruses and Sanofi-Aventis



In our agreement with Sanofi-Aventis, originally entered into in December
1995 and amended and restated in February 2001, we received exclusive rights under patents owned by Sanofi-Aventis to develop and market all products relating to pleconaril and related compounds for use in picornavirus disease indications in the
U.S. and Canada, as well as a right of first refusal for any other indications in the U.S. and Canada. We further amended our agreement with Sanofi-Aventis in November 2003 in connection with our entry into the option agreement with Schering-Plough
in respect of intranasal pleconaril. As a result of Schering-Ploughs August 2004 exercise of its option to continue the development and commercialization of pleconaril, the November 2003 amendment provided that, among other things, the royalty
rate payable to Sanofi-Aventis was reduced. Pleconaril is covered by one of the licensed U.S. patents, which expires in 2012, and one of the licensed Canadian patents, which expires in 2013. We will be dependent on Sanofi-Aventis to prosecute and
maintain certain of these patents, and to file any applications for patent term extension. We also may be dependent on Sanofi-Aventis to protect such patent rights.



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Under our agreement with Sanofi-Aventis, until the expiration or termination of the agreement, we must
make royalty payments on any sales of products in the U.S. and Canada developed under the agreement, which royalty payments will be reduced upon the expiration of the last patent on pleconaril or any related drug, except for reduced royalty payments
on Schering-Ploughs sales of the drug, if any, which extends indefinitely. We are entitled to royalties from Sanofi-Aventis on sales of products by Sanofi-Aventis outside the U.S. and Canada. Sanofi-Aventis will make a milestone payment to us
upon submission of pleconaril for regulatory approval in Japan. We are required to pay a portion of these royalties and milestones payable to Schering-Plough under our agreement with them.



Our patent licenses under the amended and restated agreement with
Sanofi-Aventis terminate on the later of expiration of the last patent licensed to us under the agreement or ten years following our first sale of a product in the U.S. or Canada containing a compound licensed to us under the agreement, or earlier
under certain circumstances. In the event that our rights to use Sanofi-Aventiss patents and trademarks terminate, under certain circumstances the agreement may restrict our ability to market pleconaril and compete with Sanofi-Aventis. In
addition, Sanofi-Aventis has the right to terminate the agreement if we are subject to a change of control that would materially and adversely affect the development, manufacturing and marketing of the products under the agreement. The term
automatically renews for successive five-year terms unless either party gives six months prior written notice of termination. We also have the right to manufacture, or contract with third parties to manufacture, any drug product derived from
the pleconaril drug substance.



Manufacturing



We currently do not have capabilities to manufacture commercial or clinical
trial supplies of drugs, and do not intend to develop such capabilities for any product in the near future. Our commercialization plans are to contract with third parties for the manufacture and distribution of our product candidates.



We entered into a supply agreement with Lilly for the manufacture and supply
of the API of Vancocin and the Vancocin finished product for an agreed-upon time period. In November 2005, we amended our manufacturing agreement with Lilly which, among other things, increased the amount of Vancocin that Lilly supplied to us during
2005, and ensured that Lilly will continue to supply us with Vancocin until at least September 30, 2006. That date will be extended to a later date if our third party supply chain is not qualified by September 30, 2006.



In December 2005 we entered into agreements with OSG Norwich Pharmaceuticals,
Inc. (OSG Norwich) to produce finished Vancocin product. We have received the required regulatory approval for the new source of Vancocin API, thereby enabling its use by our finished product manufacturer, and we are negotiating a supply
agreement with the API manufacturer. The qualification process required to transfer Vancocin manufacturing from Lilly to OSG Norwich was completed in February 2006. We anticipate that we will commence purchasing a portion of our needs from OSG
Norwich during the second quarter of 2006. We expect that all finished product will be purchased from OSG Norwich after the end of the third quarter 2006.



We require in our manufacturing and processing agreements that all third-party contract manufacturers and processors produce drug substance and product in
accordance with the FDAs current Good Manufacturing Practices and all other applicable laws and regulations. We maintain confidentiality agreements with potential and existing manufacturers in order to protect our proprietary rights related to
our marketed drug and drug candidates.



For the preparation of
compounds for preclinical development and for the manufacture of limited quantities of drug substances for clinical development, we have used both in-house capabilities and the capabilities of our collaborators, and we contract with third-party
manufacturers. In the future, we expect to rely solely on third-party manufacturers to manufacture drug substance and final drug products for both clinical development and commercial sale.



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Customers



Our net product sales are solely related to Vancocin. Our customers are wholesalers who then distribute the product to pharmacies, hospitals and long term
care facilities, among others. In the fourth quarter of 2005, three wholesalers represent approximately 95% of our total net product sales. Since Vancocin is currently the only approved oral antibiotic used to treat antibiotic-associated
pseudomembranous colitis cased by an overgrowth of C. difficile in the colon, we do not believe that the loss of any one of these wholesalers would have a material adverse effect on product sales because product sales would shift to other
wholesalers or alternative forms of distributors. However, the loss of a wholesaler could increase our dependence on a reduced number of wholesalers. Additionally, a change in agreement with a wholesaler could result in a material adverse effect on
operating results.



Marketing and Sales



We have the exclusive right to market and sell Vancocin in the U.S. and its
territories. Vancocin is distributed through wholesalers that sell the product to pharmacies, hospitals, clinics and other facilities licensed to dispense prescription medications. In order to assist in the distribution of Vancocin in the U.S., we
engaged Cardinal Health PTS, LLC, or Cardinal, in January 2005 to manage our warehousing and inventory program and to handle fulfillment of customer orders. Cardinal also provides us with order processing, shipping, collection and invoicing services
related to our product sales. We currently have a limited marketing staff and do not have a sales staff. We do not anticipate developing a sales staff for Vancocin, rather we intend to focus on educational initiatives, including thought leader
development, physician education, and the targeted education of health professionals, by utilizing a small number of medical science liaisons. As of December 31, 2005, we have hired seven members of our regional medical scientist team.



Under our agreement with GSK, we have the exclusive right to
market and sell maribavir for specific indications throughout the world (other than Japan). Under our agreement with Wyeth, we have the right to co-promote hepatitis C products arising from our collaboration in the U.S. and Canada. Under our
agreement with Schering-Plough, they have the exclusive right to market and sell pleconaril in the U.S. and Canada. The success and commercialization of our hepatitis C product candidates depend in part on the performance of Wyeth.



Schering-Plough has the exclusive right to develop and commercialize
pleconaril in the U.S. and Canada, thus the success and commercialization of pleconaril in those territories will depend entirely on the performance of Schering-Plough. If we are successful in acquiring FDA approval of maribavir or any other product
candidate that we may acquire as a result of our business development efforts, we will need to build a commercial marketing and sales capability. There is no assurance that our marketing efforts for Vancocin will be successful, that any of our
collaboration partners will be successful in commercializing the products that we have licensed to them, that our partners will adequately perform their obligations as expected, or that any revenue would be derived from such arrangements. In
addition, there is no assurance that we will be able to build our own commercial marketing and sales organization.



Patents and Proprietary Technology



We believe that patent protection and trade secret protection are important to our business and that our future will depend, in part, on our ability to
maintain our technology licenses, maintain trade secret protection, obtain patents and operate without infringing the proprietary rights of others both in the U.S. and abroad. The last core patent protecting Vancocin expired in 1996. In order to
continue to obtain commercial benefits from Vancocin, we will rely on product manufacturing trade secrets, know-how and related non-patent intellectual property, and regulatory barriers to competitive products. We own two issued U.S. patents
covering non-core vancomycin related technology. We currently have received one issued U.S. patent describing methods for treating pestivirus disease (a disease caused by viruses related to HCV) and related technology. We have one



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issued U.S. patent and two non-U.S. patents describing compounds, compositions and methods for treating respiratory syncytial virus (RSV) diseases. We have
two pending U.S. patent applications describing compounds, compositions and methods of treating and preventing picornavirus disease and one pending U.S. patent application covering methods of reducing rhinovirus contagion. We have six U.S. patent
applications that we co-own with Wyeth describing compounds and methods for treating hepatitis C and related virus diseases, including a patent application family that covers HCV-796 and claims related compounds, compositions and methods of use for
the treatment of HCV infections, as well as compounds active against pestivirus diseases. We have two U.S. patent applications describing compounds, compositions and methods for treating respiratory syncytial virus (RSV) diseases. We also have filed
related patent applications under the Patent Cooperation Treaty (PCT) as well as other non-U.S. national and/or regional patent applications. These patent applications describe compounds and methods for treating hepatitis C and related virus
diseases, pestivirus diseases, RSV diseases and rotavirus and technology, compositions and methods for identifying inhibitors of HCV and related technology. We intend to seek patent protection on these inventions in countries having significant
market potential around the world on the basis of the PCT and related foreign filings.



As patent applications in the U.S. are maintained in secrecy until patents are issued (unless earlier publication is required under applicable law or in connection with patents filed under the PCT) and as publication
of discoveries in the scientific or patent literature often lags behind the actual discoveries, we cannot be certain that we or our licensors were the first to make the inventions described in each of these pending patent applications or that we or
our licensors were the first to file patent applications for such inventions. Furthermore, the patent positions of biotechnology and pharmaceutical companies are highly uncertain and involve complex legal and factual questions, and, therefore, the
breadth of claims allowed in biotechnology and pharmaceutical patents or their enforceability cannot be predicted. We cannot be sure that any patents will issue from any of these patent applications or, should any patents issue, that we will be
provided with adequate protection against potentially competitive products. Furthermore, we cannot be sure that should patents issue, they will be of commercial value to us, or that private parties, including competitors, will not successfully
challenge these patents or circumvent our patent position in the U.S. or abroad. In the absence of adequate patent protection, our business may be adversely affected by competitors who develop comparable technology or products.



Pursuant to the terms of the Uruguay Round Agreements Act, patents filed on
or after June 8, 1995 have a term of twenty years from the date of filing, irrespective of the period of time it may take for the patent to ultimately issue. This may shorten the period of patent protection afforded to our products as patent
applications in the biopharmaceutical sector often take considerable time to issue. Under the Drug Price Competition and Patent Term Restoration Act of 1984, a sponsor may obtain marketing exclusivity for a period of time following FDA approval of
certain drug applications, regardless of patent status, if the drug is a new chemical entity or if new clinical studies were used to support the marketing application for the drug. Pursuant to the FDA Modernization Act of 1997, this period of
exclusivity can be extended if the applicant performs certain studies in pediatric patients. This marketing exclusivity prevents a third party from obtaining FDA approval for a similar or identical drug under an Abbreviated New Drug Application or a
505(b)(2) New Drug Application.



The Drug Price
Competition and Patent Term Restoration Act of 1984 also allows a patent owner to obtain an extension of applicable patent terms for a period equal to one-half the period of time elapsed between the filing of an Investigational New Drug Application,
or IND, and the filing of the corresponding New Drug Application, or NDA, plus the period of time between the filing of the NDA and FDA approval, with a five year maximum patent extension. We cannot be sure that we will be able to take advantage of
either the patent term extension or marketing exclusivity provisions of this law.



In order to protect the confidentiality of our technology, including trade secrets and know-how and other proprietary technical and business information, we require all of our employees, consultants, advisors and
collaborators to enter into confidentiality agreements that prohibit the use or disclosure of confidential information. The agreements also oblige our employees, and to the extent practicable, our consultants, advisors and collaborators, to assign
to us ideas, developments, discoveries and inventions made by such persons in



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connection with their work with us. We cannot be sure that these agreements will maintain confidentiality, will prevent disclosure, or will protect our
proprietary information or intellectual property, or that others will not independently develop substantially equivalent proprietary information or intellectual property.



The pharmaceutical industry is highly competitive and patents have been applied for by, and issued to, other parties
relating to products competitive with those being developed by us. Therefore, our product candidates may give rise to claims that they infringe the patents or proprietary rights of other parties existing now and in the future. Furthermore, to the
extent that we, or our consultants or research collaborators, use intellectual property owned by others in work performed for us, disputes may also arise as to the rights in such intellectual property or in related or resulting know-how and
inventions. An adverse claim could subject us to significant liabilities to such other parties and/or require disputed rights to be licensed from such other parties. A license required under any such patents or proprietary rights may not be
available to us, or may not be available on acceptable terms. If we do not obtain such licenses, we may encounter delays in product market introductions, or may find that we are prevented from the development, manufacture or sale of products
requiring such licenses. In addition, we could incur substantial costs in defending ourselves in legal proceedings instituted before the U.S. Patent and Trademark Office or in a suit brought against us by a private party based on such patents or
proprietary rights, or in a suit by us asserting our patent or proprietary rights against another party, even if the outcome is not adverse to us.



Government Regulation



The FDA and comparable regulatory agencies in state and local jurisdictions and in foreign countries impose substantial requirements on the clinical
development, manufacture, distribution and marketing of pharmaceutical products. These agencies and other federal, state and local entities regulate research and development activities and the testing, manufacture, processing, quality control,
safety, effectiveness, labeling, packaging, storage, handling, distribution, record keeping, approval, advertising, and promotion of our products. All of our products will require regulatory approval before commercialization. In particular,
therapeutic products for human use are subject to rigorous preclinical and clinical testing and other requirements of the Federal Food, Drug, and Cosmetic Act, implemented by the FDA, as well as similar statutory and regulatory requirements of
foreign countries. Obtaining these marketing approvals and subsequently complying with ongoing statutory and regulatory requirements is costly and time consuming. Any failure by us or our collaborators, licensors or licensees to obtain or maintain,
or any delay in obtaining, regulatory approval or in complying with other requirements, could adversely affect the commercialization of products then being developed by us and our ability to receive product or royalty revenues.



The steps required before a new drug product may be distributed commercially
in the U.S. generally include:



| | · |  | conducting appropriate preclinical laboratory evaluations of the products chemistry, formulation and stability, and animal studies to assess the potential safety and efficacy
of the product;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | submission to the FDA of an Investigational New Drug Application (IND), including the results of preclinical evaluations and tests, along with manufacturing information and
analytical data;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | obtaining approval of Institutional Review Boards, or IRBs, to introduce the drug into humans in clinical studies;
| | - |  | ------------------------------------------------------------------------------------------------------------------



| | · |  | conducting adequate and well-controlled human clinical trials that establish the safety and efficacy of the drug product candidate for the intended use, typically in the following
three sequential, or slightly overlapping stages:
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | Phase 1:    The drug is initially introduced into healthy human subjects or patients and tested for safety, dose tolerance, absorption, metabolism,
distribution, excretion and evidence of biological activity;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | · |  | Phase 2:    The drug is studied in controlled, exploratory therapeutic trials in a limited number of patients to identify possible adverse effects and
safety risks, to determine dose tolerance and the optimal effective dosage, and to collect initial efficacy data of the product for specific targeted diseases or medical conditions;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | Phase 3:    The drug is studied in an expanded, controlled patient population at multiple clinical study sites to demonstrate efficacy and safety at the
optimized dose by measuring a primary endpoint established at the outset of the study;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | submitting the results of preliminary research, animal studies, and clinical studies as well as chemistry, manufacturing and controls information and patent certification
information on the drug to the FDA in a NDA;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | undergoing a successful FDA pre-approval inspection prior to approval of an NDA; and
| | - |  | ------------------------------------------------------------------------------------



| | · |  | obtaining FDA approval of the NDA prior to any commercial sale or shipment of the drug product.
| | - |  | -----------------------------------------------------------------------------------------------



This process can take a number of years and typically requires substantial financial resources, and we cannot be certain
that any approval will be granted on a timely basis, if at all. The results of preclinical studies and initial clinical trials are not necessarily predictive of the results from large-scale clinical trials, and all clinical trials may be subject to
additional costs, delays or modifications due to a number of factors, including the difficulty in obtaining enough patients, clinical investigators, drug supply, or financial support, or because of unforeseen adverse effects. In addition, an
independent IRB at each clinical site proposing to conduct the clinical trials must review and approve each study protocol and oversee the conduct of the trial. The FDA may also raise questions about the conduct of the trials as outlined in the IND
and impose a clinical hold on the trial. If a clinical hold is imposed, all of FDAs concerns must be resolved before the trial may begin again. Preclinical and clinical studies may take several years to complete, and there is no guarantee that
an IND we submit will result in a submission of an NDA within any specific time period, if at all.



The FDA has issued regulations intended to expedite the approval process for the development, evaluation and marketing of new therapeutic products
intended to treat life-threatening or severely debilitating diseases, especially where no alternative therapies exist. If applicable, these provisions may shorten the traditional product development process in the U.S. Similarly, products that
represent a substantial improvement over existing therapies may be eligible for priority review and FDA approval time of six months. Nonetheless, even if a product is eligible for these programs, or for priority review, approval may be denied or
delayed by the FDA or additional trials may be required. As a condition of approval FDA also can require further testing of the product and monitoring of the effect of commercialized products, including the performance of tests to assess pediatric
safety and effectiveness of a pediatric formulation. The Agency has the power to prevent or limit further marketing of a product based on the results of these post-approval commitments. Upon approval, a drug product may be marketed only in those
dosage forms and for those indications approved in the NDA.



Any products manufactured or distributed by us pursuant to FDA approval are subject to extensive continuing post-approval regulation by the FDA, including record-keeping requirements, obligations to investigate, analyze and report adverse
experiences, and restrictions on advertising and promotional activities. In addition to continued compliance with standard regulatory requirements, the FDA also may require post-marketing testing and surveillance to monitor the safety and efficacy
of the marketed product. Results of post-marketing studies may limit or expand the further marketing of the products. If we propose any modifications to a product, including changes in indication, manufacturing process, manufacturing facility or
labeling, we may need to submit a NDA supplement to the FDA, and will not be able to commercialize any product with these modifications until FDA approval is received. Product approvals may be withdrawn if compliance with regulatory requirements is
not maintained or if problems concerning safety or efficacy of the product are discovered following approval.



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In addition to obtaining FDA approval for each indication to be treated with each product, each domestic
drug product manufacturing establishment must register with the FDA, list its drug products with the FDA, comply with current Good Manufacturing Practices (cGMPs) and undergo periodic inspections by the FDA.



In complying with the FDAs cGMP requirements, manufacturers must
continue to spend time, money and effort in production, recordkeeping, quality control, and auditing to ensure that the marketed product meets applicable specifications and other requirements. The FDA periodically inspects drug product manufacturing
facilities to ensure compliance with cGMPs. Failure to comply with FDA requirements, including cGMPs, subjects the manufacturer to possible FDA enforcement action, such as untitled letters, Warning Letters, suspension of manufacturing operations,
seizure of the product, voluntary or mandatory recall of a product, injunctive action, consent agreements or suspension or revocation of product approval, as well as possible civil and criminal penalties. We currently rely on, and intend to continue
to rely on, third parties to manufacture our compounds and products. Such third parties will be required to comply with FDA requirements, including cGMPs. We cannot be certain that we, or our present or future suppliers or third-party manufacturers,
will be able to comply with all FDA regulatory requirements, and potential consequences of non-compliance could have a material adverse impact on our business.



Products manufactured in the U.S. for distribution abroad will be subject to FDA regulations regarding export, as well as to the requirements of the
country to which they are shipped. These latter requirements are likely to cover the conduct of clinical trials, the submission of marketing applications, and all aspects of product manufacture and marketing. Such requirements can vary significantly
from country to country. As part of our strategic relationships, our collaborators may be responsible for the foreign regulatory approval process of our products, although we may be legally liable for noncompliance. Foreign establishments
manufacturing drug products for distribution in the U.S. also must list their products with the FDA and comply with cGMPs. They also are subject to periodic inspection by the FDA or by local authorities under agreement with the FDA.



The FDAs laws, regulations and policies may change, and additional
governmental regulations or requirements may be enacted that could delay, limit or restrict, or prevent regulatory approval of our products or affect our ability to test, manufacture, market, or distribute our products following approval.



On December 8, 2003, the Medicare Prescription Drug,
Improvement and Modernization Act (MMA) was signed into law and provides outpatient prescription drug coverage to eligible Medicare beneficiaries. The MMA established an interim prescription drug discount card program in June 2004 which allowed
Medicare beneficiaries to obtain a Medicare endorsed, drug-discount card from prescription drug card sponsors, including pharmacy benefit management companies, wholesale or retail pharmacy delivery systems, insurers, and Medicare Advantage plans.
The primary prescription drug benefit under the MMA, the new Medicare Part D coverage began in January 2006. The new Part D prescription drug benefit is administered regionally through Medicare-approved insurance plans. The legislation allows for
the importation of prescription drugs from Canada, but only if the Secretary of the U.S. Department of Health and Human Services certifies to Congress that such importation would pose no additional risk to the publics health and safety and
would result in significant reduction in the cost to customers, which the Secretary thus far has not done. There can be no assurance that this certification requirement will be maintained in future legislation or that the certification will continue
to be withheld. Prior to the MMA, federal law would have permitted importation of medicines into the U.S. from a considerably larger group of developed countries, provided the U.S. Health and Human Services Department made the same safety and
cost-savings certifications. We cannot predict the potential impact that the MMA will have on our business, because it is not clear how the law will be implemented by regulators or received by consumers and physicians. While the overall usage of
pharmaceuticals may increase as the result of the expanded access to prescription drugs afforded under Medicare Part D, this may be offset by reduced pharmaceutical prices resulting from limited coverage of particular products in a therapeutic
category and the enhanced purchasing power of the Medicare Part D plan sponsors. The impact could also be negative over the intermediate and longer term for our business generally as greater federal involvement and budget constraints may increase
the likelihood of pricing pressures or controls in the future.



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Federal and state governments also have pursued direct methods to reduce the cost of drugs for which they
pay. We participate in state government-managed Medicaid programs as well as certain other qualifying federal and state government programs whereby discounts and mandatory rebates are provided to participating state and local government entities. We
also participate in other programs with government entities, the most significant of which are the U.S. Department of Defense and the U.S. Department of Veterans Affairs. These entities receive minimum discounts based off a defined non-federal
average manufacturer price for purchases. Additional programs in which we participate provide mandatory discounts for outpatient medicines purchased by certain Public Health Service entities and disproportionate share hospitals
(hospitals meeting certain criteria regarding the percentage of needy population served).



Our operations are also subject to federal and state anti-kickback laws. Certain provisions of the Social Security Act prohibit entities such as us from knowingly and willingly offering, paying, soliciting or
receiving any form of remuneration (including any kickbacks, bribe or rebate) in return for the referral of items or services for which payment may be made under a federal health care program, or in return for the recommendation, arrangement,
purchase, lease or order of items or services for which payment may be made under a federal health care program. Violation of the federal anti-kickback law is a felony, punishable by criminal fines and imprisonment for up to five years or both. In
addition, the Department of Health and Human Services may impose civil penalties and exclude violators from participation in federal health care programs such as Medicare and Medicaid. Many states have adopted similar prohibitions against payments
intended to induce referrals of products or services paid by Medicaid or other third party payors. Several states have also enacted laws requiring recordkeeping and reporting of gifts and other value given to healthcare providers. Because of the
far-reaching nature of these laws, there can be no assurance that the occurrence of one or more violations of these laws would not result in a material adverse effect on our business, financial condition and results of operations.



We are also subject to various federal, state and local laws, rules,
regulations and policies relating to safe working conditions, clinical, laboratory and manufacturing practices, environmental protection, the experimental use of animals and the use and disposal of hazardous or potentially hazardous substances,
including radioactive compounds and infectious disease agents, previously used in connection with our research work. Although we believe that our safety procedures for handling and disposing of such materials comply with current federal, state and
local laws, rules, regulations and policies, the risk of accidental injury or contamination from these materials cannot be entirely eliminated. We may also incur significant costs to comply with such laws and regulations now and in the future, and
the failure to comply may have a material adverse impact on our business.



Moreover, we anticipate that Congress, state legislatures and the private sector will continue to review and assess controls on health care spending. Any such proposed or actual changes could cause us or our
collaborators to limit or eliminate spending on development projects and may otherwise affect us. We cannot predict the likelihood, nature, or extent of adverse governmental regulation that might result from future legislative or administrative
action, either in the U.S. or abroad. Additionally, in both domestic and foreign markets, sales of our proposed products will depend, in part, upon the availability of reimbursement from third-party payors, such as government health administration
authorities, managed care providers, private health insurers and other organizations. Significant uncertainty often exists as to the reimbursement status of newly approved health care products. In addition, third-party payors are increasingly
challenging the price and cost effectiveness of medical products and services. There can be no assurance that our proposed products will be considered cost-effective or that adequate third-party reimbursement will be available to enable us to
maintain price levels sufficient to realize an appropriate return on our investment in product research and development.



Competition



The last core patent protecting Vancocin expired in 1996. As a result, there is a potential for significant competition from generic products that treat
the same conditions addressed by Vancocin. Such competition could result in a significant reduction in sales of Vancocin. We believe that regulatory hurdles, as well as product manufacturing trade secrets, know-how and related non-patent
intellectual property may present barriers to market entry of generic competition. However, there can be no assurance that these barriers will actually delay or prevent generic competition.



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Vancocin sales for treatment of antibiotic-associated pseudomembranous colitis caused by C.
difficile have increased over the past 12 months; however, Vancocins share of the U.S. market for this indication may decrease due to competitive forces and market dynamics. Metronidazole, a generic product, is regularly prescribed to
treat CDAD at costs which are substantially lower than for Vancocin. In addition, products which are currently marketed for other indications by other companies may also be prescribed to treat this indication.



Stem cell / bone marrow and solid organ transplant patients at risk for CMV
infection or with active CMV disease are most likely to receive ganciclovir or valganciclovir (prodrug of ganciclovir), each of which were developed and are marketed by F. Hoffmann-La Roche. Ganciclovir and valganciclovir are associated with the
adverse effect of neutropenia, which may limit their use in certain patients. Foscarnet (AstraZeneca) and cidofvir (Gilead Sciences) may also be used to treat active CMV infections in certain patient populations such as neutropenic patients,
patients with ganciclovir-resistant CMV infection, or patients for whom ganciclovir is otherwise contraindicated. However, use of either foscarnet or cidofovir is limited by the side effect of renal impairment. Other broad-spectrum antiviral agents
including valaciclovir and acyclovir (GSK) are marketed in several countries, and may also be used for the prevention of CMV infection in some patients. Additionally, we believe that there is at least one vaccine product in early-phase clinical
trials and that there are several preclinical drug development initiatives targeted for this indication. The objective of the maribavir clinical program is to demonstrate that maribavir is at least as efficacious as the currently existing treatments
with a better safety profile.



The most commonly used
treatments for HCV are alfa-interferon products, alone or in combination with ribavirin. There are a number of products in clinical development including immunomodulators and specific inhibitors of HCV, making this a highly competitive field of
clinical research. There currently are no approved antiviral agents directed specifically against HCV and no vaccine for prevention of HCV infection, although several companies, in addition to Wyeth and us, are working on developing such products.
Approximately 30-50% of patients who receive full courses of currently available therapies achieve a sustained virologic response. There are several interferon products available worldwide, but there are substantial limitations to the use of these
products when given as monotherapy or in conjunction with ribavirin in the treatment of chronic HCV infection. These include poor treatment response in patients infected with particular genotypes of the virus and significant side effects that can
lead to discontinuation of therapy in approximately 20% of patients. We believe that this is an underserved market and are working with Wyeth toward advancing a specific antiviral product candidate for treatment of HCV. We believe that in the
future, as new antiviral agents become available, patients with HCV will likely be treated with various combination therapies analogous to the treatment paradigm for HIV. Such combinations of antiviral agents could include non-nucleoside polymerase
inhibitors, such as HCV-796, protease inhibitors and nucleoside polymerase inhibitors, all with or without interferon therapy. As a result, we believe HCV-796 may be complementary to certain other antiviral agents.



In addition to approved products, other companies are developing treatments
for infectious diseases, including compounds in preclinical and clinical development for C. difficile, CMV, HCV and rhinovirus infections. These companies include both public and private entities, including well-known, large pharmaceutical
companies, chemical companies, biotechnology companies and research institutions. For example, Genzyme Corporation, Oscient Pharmaceuticals and Optimer Pharmaceuticals have product candidates in clinical development for the treatment of C.
difficile associated diarrhea that could be found to have competitive advantages over Vancocin. Approval of new products, or expanded use of currently available products, to treat CDAD, and particularly severe disease caused by C.
difficile infection, could materially and adversely affect our sales of Vancocin. We believe that there is at least one vaccine product in clinical trials and that there are several preclinical drug development initiatives targeted for the
prevention of CMV infection. In addition, several other companies, including Idenix, Vertex and Schering-Plough, are developing compounds to treat hepatitis C. Developments by these or other entities may render our products under development
non-competitive or obsolete. Our ability to compete successfully will be based on our ability to:



| | · |  | develop proprietary products;
| | - |  | -----------------------------



| | · |  | attract and retain scientific personnel;
| | - |  | ----------------------------------------



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| | · |  | obtain patent or other protection for our products;
| | - |  | ---------------------------------------------------



| | · |  | obtain required regulatory approvals; and
| | - |  | -----------------------------------------



| | · |  | manufacture and successfully market our products either alone or through outside parties.
| | - |  | -----------------------------------------------------------------------------------------



We intend to evaluate in-licensing or other opportunities to acquire products in development, or those that are currently on
the market. We plan to seek products for diseases treated by physician specialists and in hospital settings to complement the markets that we hope our CMV and HCV programs will serve or in which Vancocin is prescribed. We will face intense
competition in acquiring products to expand our product portfolio. Many of the companies and institutions that we will compete with in acquiring products to expand our product portfolio have substantially greater capital resources, research and
development staffs and facilities than we have.



Many of our
competitors have substantially greater financial, research and development, manufacturing, marketing and human resources and greater experience in product discovery, development, clinical trial management, FDA regulatory review, manufacturing and
marketing than we do.



Employees



As of February 24, 2006, we had 48 employees and we are currently
seeking to fill certain additional positions. A significant number of our management and professional employees have had prior experience with pharmaceutical, biotechnology or medical products companies. None of our employees are covered by
collective bargaining agreements. We believe that we have been successful in attracting skilled and experienced personnel; however, competition for such personnel is intense. We believe that our relations with our employees are good.



Legal Proceedings



We are currently not involved in any material litigation.



Executive Officers



|                  |  |     |  |                                                                               
|----------------- |  | --- |  | ------------------------------------------------------------------------------
|Name              |  | Age |  | Position                                                                      
|Michel de Rosen   |  | 54  |  | President, Chief Executive Officer and Chairman of the Board of Directors     
|Colin Broom, M.D. |  | 50  |  | Vice President, Chief Scientific Officer                                      
|Thomas F. Doyle   |  | 45  |  | Vice President, General Counsel and Secretary                                 
|Vincent J. Milano |  | 42  |  | Vice President, Chief Operating Officer, Chief Financial Officer and Treasurer
|Joshua M. Tarnoff |  | 42  |  | Vice President, Chief Commercial Officer                                      



Michel de Rosen has
served as our Chairman of the Board of Directors since September 2002, President and Chief Executive Officer since August 2000, and as a director since May 2000. From 1993 to 1999, Mr. de Rosen held several key positions in Rhone-Poulenc Pharma
and Rhone-Poulenc Rorer (now Sanofi-Aventis), including Chief Executive Officer from May 1995 until December 1999, and Chairman and CEO from 1996 to 1999. Mr. de Rosen began his career at the French Ministry of Finance and subsequently served
in several leading government positions. Mr. de Rosen also served in various executive roles in industry prior to 1993. Mr. de Rosen holds a MBA from the Ecole des Hautes Etudes Commerciales in France. Mr. de Rosen also is a director
of ABB Ltd.



Colin Broom, M.D. has served as Vice President,
Chief Scientific Officer of ViroPharma since May 2004. From 2000 until December 2003, Dr. Broom served as Vice President of Clinical Development and Medical Affairs, Europe, for Amgen Inc. From 1998 to 1999, Dr. Broom served as Senior Vice
President of Global Clinical Development for Hoechst Marion Roussel, now Sanofi-Aventis. From 1987 until 1998 Dr. Broom held positions of increasing seniority in clinical pharmacology at SmithKline Beecham in Europe before moving to



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the U.S. to head global oncology and subsequently becoming Vice President of CNS/GI. From 1984 through 1987, Dr. Broom was a research physician with
Glaxo Group Research Ltd. Dr. Broom holds a Bachelor of Science degree in pharmacology from University College London, and a Bachelor of Medicine and Bachelor of Surgery degree from St. Georges Hospital Medical School. Dr. Broom is a
Member of the Royal College of Physicians and a Fellow of the Faculty of Pharmaceutical Medicine of the UK Colleges of Physicians.



Thomas F. Doyle has served as Vice President, General Counsel of ViroPharma since November 1997, as Secretary since February 1997 and as Executive
Director, Counsel since joining ViroPharma in November 1996. From 1990 until 1996, Mr. Doyle was a corporate attorney with the law firm of Pepper Hamilton LLP. Mr. Doyle received his J.D. from Temple University School of Law. Prior to
attending Temple University, Mr. Doyle was a Certified Public Accountant. Mr. Doyle received his B.S. in Accounting from Mt. St. Marys College.



Vincent J. Milano has served as Chief Operating Officer since January 2006, as Vice President, Chief Financial Officer of ViroPharma since November
1997, as Vice President, Finance & Administration since February 1997, as Treasurer since July 1996, and as Executive Director, Finance & Administration from April 1996 until February 1997. From 1985 until 1996, Mr. Milano was
with KPMG LLP, where he was Senior Manager since 1991. Mr. Milano received his B.S. in Accounting from Rider College. Mr. Milano also is a director of VerticalNet, Inc.



Joshua M. Tarnoff has served as Vice President, Chief Commercial Officer since August 2004. Prior to joining ViroPharma, he
served as the Senior Marketing Director, Phoenix Business Unit (Established Brands Business Unit), at AstraZeneca Pharmaceuticals. During his tenure, Mr. Tarnoff created the Phoenix Business Unit with responsibility for improving and maximizing
AstraZeneca Pharmaceuticals established brands portfolio. Prior to AstraZeneca Pharmaceuticals, he held positions of increasing seniority at Astra Merck and Astra Pharmaceuticals, including his service as the Director of Marketing of the
Respiratory Therapeutics Area and similar roles in the Cardiovascular Therapeutic Area. Mr. Tarnoff holds a Bachelor of Arts degree in biology from LaSalle University.



Available Information



Our Internet website is www.viropharma.com and you may find our SEC filings on the Investors page of that website. We provide access to all of
our filings with the U.S. Securities and Exchange Commission, or SEC, free of charge, as soon as reasonably practicable after filing with the SEC on such site. Our Internet website and the information contained on that website, or accessible from
our website, is not intended to be incorporated into this Annual Report on Form 10-K.



|ITEM 1A.    RISK | FACTORS
|---------------- | -------



You should carefully consider the risk factors described below and all other information contained or incorporated by reference in this Annual Report
on Form 10-K before you make an investment decision. If any of the following risk factors, as well as other risks and uncertainties that are not currently known to us or that we currently believe are not material, actually occur, our business,
financial condition and results of operations could be materially and adversely affected. In that case, the trading price of our common stock could decline, and you may lose part or all of your investment.



We depend heavily on the continued sales of Vancocin.



If revenue from Vancocin materially declines, our financial condition and
results of operations will be materially harmed because, other than potential royalties and milestone payments, sales of Vancocin may be our only source of revenue for at least the next several years.



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Vancocin product sales could be adversely affected by a number of factors, including:



| | · |  | manufacturing or supply interruptions, including, difficulties encountered in qualifying a third party supply chain, which could impair our ability to acquire an adequate supply of
Vancocin to meet demand for the product;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | changes in the prescribing or procedural practices of physicians in the areas of infectious disease, gastroenterology and internal medicine, including off-label prescribing of other
products;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | the development of competitive generic versions of oral Vancocin, approval of products which are currently marketed for other indications by other companies or new pharmaceuticals
and technological advances to treat the conditions addressed by Vancocin;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | decreases in the rate of infections for which Vancocin is prescribed;
| | - |  | ---------------------------------------------------------------------



| | · |  | decrease in the sensitivity of the relevant bacterium to Vancocin;
| | - |  | ------------------------------------------------------------------



| | · |  | changes in terms required by wholesalers, including fee-for-service contracts;
| | - |  | --------------------------------------------------------------------------------



| | · |  | marketing or pricing actions by one or more of our competitors;
| | - |  | ---------------------------------------------------------------



| | · |  | our ability to maintain all necessary contracts or obtain all necessary rights under applicable federal and state rules and regulations;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------



| | · |  | the approval of legislative proposals that would authorize re-importation of Vancocin into the U.S. from other countries;
| | - |  | -------------------------------------------------------------------------------------------------------------------------



| | · |  | regulatory action by the FDA and other government regulatory agencies;
| | - |  | ----------------------------------------------------------------------



| | · |  | changes in the reimbursement or substitution policies of third-party payors or retail pharmacies; and
| | - |  | -----------------------------------------------------------------------------------------------------



| | · |  | product liability claims.
| | - |  | -------------------------



We cannot assure you that revenues from the sale of Vancocin will remain at or above current levels or achieve the level of net product sales that we
expect. A decrease in sales of Vancocin could result in our inability to maintain profitability and could have a material adverse effect on our business, financial condition and results of operations.



Core patent protection for Vancocin has expired, which could result in significant
competition from generic products and lead to a significant reduction in sales of Vancocin.



The last core patent protecting Vancocin expired in 1996. As a result, there is a potential for significant competition from generic products that treat
the same conditions addressed by Vancocin. Such competition could result in a significant reduction in sales of Vancocin. We believe that regulatory hurdles, as well as product manufacturing trade secrets, know-how and related non-patent
intellectual property may present barriers to market entry of generic competition. However, there can be no assurance that these barriers will actually delay or prevent generic competition. The effectiveness of these non-patent-related barriers to
competition will depend primarily upon:



| | · |  | the nature of the market which Vancocin serves and the position of Vancocin in the market from time to time;
| | - |  | ------------------------------------------------------------------------------------------------------------



| | · |  | the growth of the market which Vancocin serves;
| | - |  | -----------------------------------------------



| | · |  | our ability to protect Vancocin know-how as a trade secret;
| | - |  | -----------------------------------------------------------



| | · |  | the complexities of the manufacturing process for a competitive product; and
| | - |  | ----------------------------------------------------------------------------



| | · |  | the current or future regulatory approval requirements for any generic applicant.
| | - |  | ---------------------------------------------------------------------------------



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We cannot assure you that generic competitors will not take advantage of the absence of patent protection
for Vancocin to attempt to develop a competing product. From time to time we have become aware of information suggesting that other potential competitors may be attempting to develop a competing generic product. For example, on November 8,
2005, Akorn, Inc. announced that it had signed a letter of intent with Cipla, Ltd., to develop and supply an oral anti-infective Abbreviated New Drug Application, or ANDA, drug product which is distributed and used primarily in U.S. hospitals and
has a current market size of approximately $100 million. Akorn disclosed that Cipla will be responsible for the development and manufacturing of the drug, and Akorn will be responsible for the ANDA regulatory submission and clinical development. The
product was not identified, but may be an oral formulation of vancomycin. Except as discussed above, we are not aware of any public announcements, regulatory filings or public statements that potential generic competitors are developing a competing
product.



We are not able to predict the time period in which a
generic drug may enter the market, as this timing will be affected by a number of factors, including:



| | · |  | the time required to develop appropriate manufacturing procedures;
| | - |  | ------------------------------------------------------------------



| | · |  | whether a method of demonstrating bioequivalence, or other in-vitro method, is available to an applicant to gain marketing approval by the FDA in lieu of performing clinical
studies;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | the nature of any clinical trials which are required, if any; and
| | - |  | -----------------------------------------------------------------



| | · |  | the specific formulation of drug for which approval is being sought.
| | - |  | --------------------------------------------------------------------



If a generic competitor were to formulate a competing product that was approved by the FDA and that gained market acceptance, it would have a material
adverse effect on our sales of Vancocin and on our business.



We do not know
whether Vancocin will continue to be competitive in the markets which it serves.



We currently generate revenues from sales of Vancocin in the U.S. for the treatment of antibiotic-associated pseudomembranous colitis caused by Clostridium difficile, or C. difficile, and enterocolitis
caused by S. aureus, including methicillin-resistant strains. Vancocin sales for treatment of antibiotic-associated pseudomembranous colitis caused by C. difficile have increased over the past 12 months; however, Vancocins share
of the U.S. market for this indication may decrease due to competitive forces and market dynamics. Metronidazole, a generic product, is regularly prescribed to treat CDAD at costs which are substantially lower than for Vancocin. In addition,
products which are currently marketed for other indications by other companies may also be prescribed to treat this indication. Other drugs that are still in development by our competitors, including Genzyme Corporation, Oscient Pharmaceuticals, and
Optimer Pharmaceuticals, could be found to have competitive advantages over Vancocin. Approval of new products, or expanded use of currently available products, to treat CDAD, and particularly severe disease caused by C. difficile infection,
could materially and adversely affect our sales of Vancocin.



We rely on a
single third party to perform the distribution and logistics services for Vancocin.



We rely on a single third party to provide all necessary distribution and logistics services with respect to our sales of Vancocin, including warehousing of finished product, accounts receivable management, billing,
collection and recordkeeping. If our third party ceases to be able to provide us with these services, or does not provide these services in a timely or professional manner, it could significantly disrupt our commercial operations, and may result in
our not achieving the sales of Vancocin that we expect. Additionally, any interruption to these services could cause a delay in delivering product to our customers, which could have a material adverse effect on our business.



The third party service provider stores and distributes our products from a
single warehouse located in the central U.S. A disaster occurring at or near this facility could materially and adversely impact our ability to supply Vancocin to our wholesalers which would result in a reduction in revenues from sales of Vancocin.



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Our sales are mainly to a limited number of pharmaceutical wholesalers, and changes in terms required by these
wholesalers or disruptions in these relationships could result in us not achieving the sales of Vancocin that we expect.



Approximately 95% of our Vancocin sales are to the three largest pharmaceutical wholesalers. If any of these wholesalers ceases to purchase our
product for any reason, then unless and until the remaining wholesalers increase their purchases of Vancocin or alternative distribution channels are established:



| | · |  | our commercial operations could be significantly disrupted;
| | - |  | -----------------------------------------------------------



| | · |  | the availability of Vancocin to patients could be disrupted; and
| | - |  | ----------------------------------------------------------------



| | · |  | we may not achieve the sales of Vancocin that we expect, which could decrease our revenues and potentially affect our ability to maintain profitability.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------



We are aware that wholesalers have, in the past, entered into fee-for-service
agreements with pharmaceutical companies in connection with the distribution of their products. Although we do not currently have such agreements in place with our wholesalers, our entering into fee-for-service arrangements with wholesalers could
result in higher costs to us and adversely affect our product margins. Additionally, we do not require collateral from our wholesalers but rather maintain credit limits and as a result we have an exposure to credit risk in our accounts
receivable. The highest account receivable we have experienced from any one wholesaler was approximately $13 million and we anticipate that this amount could increase if Vancocin sales continue to increase. While we have experienced prompt payment
by wholesalers and have not had any defaults on payments owed, a default by a large wholesaler could have a material adverse effect on our revenues and our earnings.



If our supplies of Vancocin finished product or any other approved products are interrupted or if we are unable to acquire adequate
supplies of Vancocin or any other approved products to meet increasing demand for the products, our ability to maintain our inventory levels could suffer and future revenues may be delayed or reduced.



We will try to maintain Vancocin inventory levels to meet our current
projections, plus a reasonable stock in excess of those projections. Any interruption in the supply of Vancocin finished products could hinder our ability to timely distribute Vancocin and satisfy customer demand. If we are unable to obtain adequate
product supplies to satisfy our customers orders, we may lose those orders, our customers may cancel other orders, and they may choose instead to stock and purchase competing products. This in turn could cause a loss of our market share and
negatively affect our revenues. Supply interruptions may occur and our inventory may not always be adequate. Our initial manufacturing agreement with Lilly relating to the manufacture of Vancocin capsules, required that Lilly continue to supply
Vancocin capsules to us until the earlier of the qualification of a third party supply chain for Vancocin capsules or the expiration of the manufacturing agreement. As a result of increased demand for Vancocin during the first nine months of 2005,
we entered into an amendment to this agreement in November 2005, which increased the amount of Vancocin that Lilly supplied to us during 2005, and ensures that Lilly will continue to supply us with Vancocin until at least September 30, 2006.
That date will be extended if our third party supply chain is not qualified by September 30, 2006. We and Lilly are in the process of qualifying the third party supply chain. In December 2005, we entered into agreements with OSG Norwich for the
manufacture of finished product. We have received the required regulatory approval for the new source of Vancocin API, thereby enabling its use by our finished product manufacturer, and we are negotiating a supply agreement with the API
manufacturer. The qualification process required to transfer Vancocin manufacturing from Lilly to OSG Norwich was substantially completed in February 2006. We anticipate that we will commence purchasing a portion of our needs from this party in the
second quarter of 2006. However, we cannot assure you that there will be no disruption in the availability of sufficient supply to meet the demand for Vancocin.



Lilly currently is, and will be until the final qualification of our third party finished product supplier, the only manufacturer qualified by the FDA
to manufacture Vancocin capsule finished product for distribution and sale in the U.S. Upon expiration of our agreement with Lilly, we will be dependent upon a single third party finished product supplier.



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Numerous factors could cause interruptions in the supply of our Vancocin finished products or other
approved products, including manufacturing capacity limitations, changes in our sources for manufacturing, our failure to timely locate and obtain replacement manufacturers as needed and conditions affecting the cost and availability of raw
materials. Lilly experienced a supply interruption during 2002 due to changes in quality standards for Vancocin and its components and there is no assurance that we will not experience similar or dissimilar supply interruptions. In addition, any
commercial dispute with any of our suppliers could result in delays in the manufacture of our product, and affect our ability to commercialize our products.



We cannot be certain that manufacturing sources will continue to be available or that we can continue to out-source the manufacturing of our products on
reasonable or acceptable terms. Any loss of a manufacturer or any difficulties that could arise in the manufacturing process could significantly affect our inventories and supply of products available for sale. If we are unable to supply sufficient
amounts of our products on a timely basis, our market share could decrease and, correspondingly, our revenues would decrease.



We maintain business interruption insurance which could mitigate some of our loss of income in the event of certain covered interruptions of supply.
However, this insurance coverage is unlikely to completely mitigate the harm to our business from the interruption of the manufacturing of products. The loss of a manufacturer could still have a negative effect on our sales, margins and market
share, as well as our overall business and financial results.



We currently
depend, and will in the future continue to depend, on third parties to manufacture our products, including Vancocin and our product candidates. If these manufacturers fail to meet our requirements and the requirements of regulatory authorities, our
future revenues may be materially adversely affected.



We
do not have the internal capability to manufacture commercial quantities of pharmaceutical products under the FDAs current Good Manufacturing Practice regulations, or cGMPs. In order to continue to develop products, apply for regulatory
approvals and commercialize our products, we will need to contract with third parties that have, or otherwise develop, the necessary manufacturing capabilities.



There are a limited number of manufacturers that operate under cGMPs that are capable of manufacturing our products and product candidates. If we are
unable to enter into supply and processing contracts with any of these manufacturers or processors for our development stage product candidates, there may be additional costs and delays in the development and commercialization of these product
candidates. If we are required to find an additional or alternative source of supply, there may be additional costs and delays in the development or commercialization of our product candidates. Additionally, the FDA inspects all commercial
manufacturing facilities before approving a new drug application, or NDA, for a drug manufactured at those sites. If any of our manufacturers or processors fails to pass this FDA inspection, the approval and eventual commercialization of our
products and product candidates may be delayed.



All of our
contract manufacturers must comply with the applicable cGMPs, which include quality control and quality assurance requirements as well as the corresponding maintenance of records and documentation. If our contract manufacturers do not comply with
the applicable cGMPs and other FDA regulatory requirements, the availability of marketed products for sale could be reduced, our product commercialization could be delayed or subject to restrictions, we may be unable to meet demand for our products
and may lose potential revenue and we could suffer delays in the progress of clinical trials for products under development. We do not have control over our third-party manufacturers compliance with these regulations and standards. Moreover,
while we may choose to manufacture products in the future, we have no experience in the manufacture of pharmaceutical products for clinical trials or commercial purposes. If we decide to manufacture products, we would be subject to the regulatory
requirements described above. In addition, we would require substantial additional capital and would be subject to delays or difficulties encountered in manufacturing pharmaceutical products. No matter who manufactures the product, we will be
subject to continuing obligations regarding the submission of safety reports and other post-market information.



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If we encounter delays or difficulties with contract manufacturers, packagers or distributors, market
introduction and subsequent sales of our products could be delayed. If we change the source or location of supply or modify the manufacturing process, FDA and other regulatory authorities will require us to demonstrate that the product produced by
the new source or location or from the modified process is equivalent to the product used in any clinical trials that were conducted. If we are unable to demonstrate this equivalence, we will be unable to manufacture products from the new source or
location of supply, or use the modified process, we may incur substantial expenses in order to ensure equivalence, and it may harm our ability to generate revenues.



If we, or our manufacturers, are unable to obtain raw and intermediate materials needed to manufacture our products in sufficient amounts
or on acceptable terms, we will incur significant costs and sales of our products would be delayed or reduced.



We, or the manufacturers with whom we contract, may not be able to maintain adequate relationships with current or future suppliers of raw or intermediate
materials for use in manufacturing our products or product candidates. If our current manufacturing sources and suppliers are unable or unwilling to make these materials available to us, or our manufacturers, in required quantities or on acceptable
terms, we would likely incur significant costs and delays to qualify alternative manufacturing sources and suppliers. If we are unable to identify and contract with alternative manufacturers when needed, sales of our products would be delayed or
reduced and will result in significant additional costs.



Our future product
revenues from sales of Vancocin could be reduced by imports from countries where Vancocin is available at lower prices.



Vancocin has been approved for sale outside of the U.S., including but not limited to Canada, Brazil and Europe, and Lilly or its licensees will continue
to market Vancocin outside of the U.S. There have been cases in which pharmaceutical products were sold at steeply discounted prices in markets outside the U.S. and then imported to the United States where they could be resold at prices higher than
the original discounted price, but lower than the prices commercially available in the U.S. If this happens with Vancocin our revenues would be adversely affected. Additionally, there are non-U.S., Internet-based companies supplying Vancocin
directly to patients at significantly reduced prices.



In
recent years, various legislative proposals have been offered in the U.S. Congress and in some state legislatures that would authorize re-importation of pharmaceutical products into the U.S. from other countries including Canada. We cannot predict
the outcome of such initiatives, which if adopted, could result in increased competition for our products and lower prices.



Orders for Vancocin may fluctuate depending on the inventory levels held by our major customers. Significant increases and decreases in orders from our major customers
could cause our operating results to vary significantly from quarter to quarter.



Our customers for Vancocin include some of the nations leading wholesale pharmaceutical distributors. We attempt to monitor wholesaler inventory of our products using a combination of methods, including tracking
prescriptions filled at the pharmacy level to determine inventory amounts sold from the wholesalers to their customers. However, our estimates of wholesaler inventories may differ significantly from actual inventory levels. Significant differences
between actual and estimated inventory levels may result in excessive inventory production, inadequate supplies of products in distribution channels, insufficient or excess product available at the retail level, and unexpected increases or decreases
in orders from our major customers. Forward-buying by wholesalers, for example, may result in significant and unexpected changes in customer orders from quarter to quarter. These changes may cause our revenues to fluctuate significantly from quarter
to quarter, and in some cases may cause our operating results for a particular quarter to be below our expectations or projections. If our financial results are below expectations for a particular period, the market price of our securities may drop
significantly.



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Historically, Vancocin has been subject to limitations on the amount of payment and reimbursement available to
patients from third party payors.



Historically, only a
portion of the cost of Vancocin prescriptions is paid for or reimbursed by managed care organizations, government and other third-party payors. This reimbursement policy makes Vancocin less attractive, from a net-cost perspective, to patients and,
to a lesser degree, prescribing physicians. For example, metronidazole, a drug frequently prescribed for CDAD, is significantly less expensive than Vancocin. If adequate reimbursement levels are not provided for Vancocin, or if reimbursement
policies increasingly favor other products, our market share and gross margins could be negatively affected, as could our overall business and financial condition.



Our long-term success depends upon our ability to develop, receive regulatory approval for and commercialize drug product candidates and
if we are not successful, our ability to generate revenues from the commercialization and sale of products resulting from our product candidates will be limited.



All of our drug candidates will require governmental approvals prior to commercialization. We have not completed the
development of or received regulatory approval to commercialize any of our existing product candidates. Our failure to develop, receive regulatory approvals for and commercialize our development stage product candidates successfully will prevent us
from generating revenues from the sale of products resulting from our product candidates. Our product candidates are at early stages of development and may not be shown to be safe or effective. We are performing a Phase 2 clinical trial on a product
candidate for the prevention and treatment of CMV and reported preliminary results of a Phase 1b clinical trial of a product candidate for the treatment of HCV in November 2005. Our Phase 1b trial enrolled six cohorts of up to 16 patients each, with
12 receiving HCV-796 and four receiving placebo, with the objective of comparing HCV-796s safety and tolerability to a placebo; characterizing the compounds pharmacokinetic profile; and comparing the antiviral effect of HCV-796 with that
of a placebo on plasma HCV RNA concentrations. The clinical trial results of our Phase 1b HCV clinical trial are preliminary and full analysis of the data, and further testing including clinical studies of HCV-796 in combination with pegylated
interferon, or the larger clinical trials which will be required in order to achieve regulatory approval, may be inconsistent with the preliminary results and may not support further clinical development. Our potential therapies under development
for the treatment of CMV and HCV will require significant additional development efforts and regulatory approvals prior to any commercialization. We cannot be certain that our efforts and the efforts of our partners in this regard will lead to
commercially viable products. For example, in May 2002, we received a not approvable letter from the FDA in connection with an oral formulation of pleconaril to treat the common cold. We have since out-licensed pleconaril, an intranasal
product candidate for the treatment of the common cold, to Schering-Plough. Negative, inconclusive or inconsistent clinical trial results could prevent regulatory approval, increase the cost and timing of regulatory approval, cause us to perform
additional studies or to file for a narrower indication than planned. We do not know what the final cost to manufacture our CMV and HCV product candidates in commercial quantities will be, or the dose required to treat patients and, consequently,
what the total cost of goods for a treatment regimen will be.



If we are unable to successfully develop our product candidates, we will not have a source of revenue other than Vancocin. Moreover, the failure of one or more of our product candidates in clinical development could harm our ability to
raise additional capital.



The development of any of our
product candidates is subject to many risks, including that:



| | · |  | the product candidate is found to be ineffective or unsafe;
| | - |  | -----------------------------------------------------------



| | · |  | the clinical test results for the product candidate delay or prevent regulatory approval;
| | - |  | -----------------------------------------------------------------------------------------



| | · |  | the FDA forbids us to initiate or continue testing of the product candidates in human clinical trials;
| | - |  | ------------------------------------------------------------------------------------------------------



| | · |  | the product candidate cannot be developed into a commercially viable product;
| | - |  | -----------------------------------------------------------------------------



| | · |  | the product candidate is difficult and/or costly to manufacture;
| | - |  | ----------------------------------------------------------------



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| | · |  | the product candidate later is discovered to cause adverse effects that prevent widespread use, require withdrawal from the market, or serve as the basis for product liability
claims;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | third party competitors hold proprietary rights that preclude us from marketing the product candidate; and
| | - |  | ----------------------------------------------------------------------------------------------------------



| | · |  | third party competitors market a more clinically effective, safer, or more cost-effective product.
| | - |  | --------------------------------------------------------------------------------------------------



Even if we believe that the clinical data demonstrates the safety and efficacy of a product candidate, regulators may
disagree with us, which could delay, limit or prevent the approval of such product candidate. As a result, we may not obtain regulatory approval, or even if a product is approved, we may not obtain the labeling claims we believe are necessary or
desirable for the promotion of the product. In addition, regulatory approval may take longer than we expect as a result of a number of factors, including failure to qualify for priority review of our application. All statutes and regulations
governing the approval of our product candidates are subject to change in the future. These changes may increase the time or cost of regulatory approval, limit approval, or prevent it completely.



Even if we receive regulatory approval for our product candidates, or acquire
the rights to additional already approved products, the later discovery of previously unknown problems with a product, manufacturer or facility may result in adverse consequences, including withdrawal of the product from the market. Approval of a
product candidate may be conditioned upon certain limitations and restrictions as to the drugs use, or upon the conduct of further studies, and may be subject to continuous review.



The regulatory process is expensive, time consuming and uncertain and may prevent us from obtaining required approvals for the
commercialization of our product candidates.



We have
product candidates for the treatment of CMV and HCV in clinical development. Schering-Plough is conducting the clinical development of pleconaril. We must complete significant laboratory, animal and clinical testing on these product candidates
before we submit marketing applications in the U.S. and abroad.



The rate of completion of clinical trials depends upon many factors, including the rate of enrollment of patients. For example, our enrollment of patients in our clinical trial for maribavir has been impacted by our ability to identify and
successfully recruit a sufficient number of patients who have undergone allogeneic hematopoietic stem cell/bone marrow transplantation. If we are unable to accrue sufficient clinical patients who are eligible to participate in the trials during the
appropriate period, we may need to delay our clinical trials and incur significant additional costs. In addition, the FDA or Institutional Review Boards may require us to delay, restrict, or discontinue our clinical trials on various grounds,
including a finding that the subjects or patients are being exposed to an unacceptable health risk. Moreover, we may be unable to submit a NDA to the FDA for our product candidates within the timeframe we currently expect. Once a NDA is submitted,
it must be approved by the FDA before we can commercialize the product described in the application. The cost of human clinical trials varies dramatically based on a number of factors, including:



| | · |  | the order and timing of clinical indications pursued;
| | - |  | -----------------------------------------------------



| | · |  | the extent of development and financial support from corporate collaborators;
| | - |  | -----------------------------------------------------------------------------



| | · |  | the number of patients required for enrollment;
| | - |  | -----------------------------------------------



| | · |  | the length of time required to enroll these patients;
| | - |  | -----------------------------------------------------



| | · |  | the costs and difficulty of obtaining clinical supplies of the product candidate; and
| | - |  | -------------------------------------------------------------------------------------



| | · |  | the difficulty in obtaining sufficient patient populations and clinicians.
| | - |  | --------------------------------------------------------------------------



Even if we obtain positive preclinical or clinical trial results in initial studies, future clinical trial results may not be similarly positive. As a
result, ongoing and contemplated clinical testing, if permitted by governmental



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authorities, may not demonstrate that a product candidate is safe and effective in the patient population and for the disease indications for which we
believe it will be commercially advantageous to market the product. The failure of our clinical trials to demonstrate the safety and efficacy of our product candidate for the desired indications could delay the commercialization of the product.



In 2003, Congress enacted the Pediatric Research Equity Act
requiring the development and submission of pediatric use data for new drug products. Our failure to obtain these data, or to obtain a deferral of, or exemption from, this requirement could adversely affect our chances of receiving regulatory
approval, or could result in regulatory or legal enforcement actions.



Even
after we receive regulatory approval, as with Vancocin, if we fail to comply with regulatory requirements, or if we experience unanticipated problems with our approved products, our products could be subject to restrictions or withdrawal from the
market.



Vancocin is, and any other product for which we
obtain marketing approval from the FDA or other regulatory authority will be, along with the manufacturing processes, post-approval clinical data collection and promotional activities for each such product, subject to continual review and periodic
inspection by the FDA and other regulatory bodies. After approval of a product, we will have, and with Vancocin, we currently have, significant ongoing regulatory compliance obligations. Later discovery of previously unknown problems with our
products or manufacturing processes, or failure to comply with regulatory requirements, may result in penalties or other actions, including:



| | · |  | warning letters;
| | - |  | ----------------



| | · |  | fines;
| | - |  | ------



| | · |  | product recalls;
| | - |  | ----------------



| | · |  | withdrawal of regulatory approval;
| | - |  | ----------------------------------



| | · |  | operating restrictions, including restrictions on such products or manufacturing processes;
| | - |  | -------------------------------------------------------------------------------------------



| | · |  | disgorgement of profits;
| | - |  | ------------------------



| | · |  | injunctions; and
| | - |  | ----------------



| | · |  | criminal prosecution.
| | - |  | ---------------------



Any of these events could result in a material adverse effect on our revenues and financial condition.



There are many potential competitors with respect to our product candidates under
development, who may develop products and technologies that make ours non-competitive or obsolete.



There are many entities, both public and private, including well-known, large pharmaceutical companies, chemical companies, biotechnology companies and
research institutions, engaged in developing pharmaceuticals for applications similar to those targeted by our products under development.



There are products already marketed by F. Hoffman La-Roche, AstraZeneca and Gilead Sciences Inc. for the prevention and treatment of CMV and
Schering-Plough and F. Hoffman La-Roche for the treatment of HCV. We are aware of a number of other companies which have compounds in various stages of clinical development for the treatment HCV. Developments by these or other entities may render
our product candidates non-competitive or obsolete. Furthermore, many of our competitors are more experienced than we are in drug development and commercialization, obtaining regulatory approvals and product manufacturing and marketing. Accordingly,
our competitors may succeed in obtaining regulatory approval for products more rapidly and more effectively than we do for our product candidates. Competitors may succeed in developing products that are more effective and less costly than any that
we develop and also may prove to be more successful in the manufacturing and marketing of products.



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Any product that we successfully develop and for which we gain regulatory approval must then compete for
market acceptance and market share. Accordingly, important competitive factors, in addition to completion of clinical testing and the receipt of regulatory approval, will include product efficacy, safety, timing and scope of regulatory approvals,
availability of supply, marketing and sales capacity, reimbursement coverage, pricing and patent protection. Our products could also be rendered obsolete or uneconomical by regulatory or competitive changes.



In order to continue to expand our business and sustain our revenue growth, we will need
to acquire additional marketed products through in-licensing or the acquisitions of businesses that we believe are a strategic fit with us. We may not be able to in-license or acquire suitable products at an acceptable price or at all. In addition,
engaging in any in-licensing or acquisitions will incur a variety of costs, and we may never realize the anticipated benefits of any such in-license or acquisition.



As part of our long-term strategy and in order to sustain our revenue growth, we intend to seek to acquire or in-license
additional products to treat the patient population targeted by Vancocin and our current product candidates, or products to treat other diseases for which patients are treated by physician specialists or in hospital settings. Even if we are able to
locate products or businesses that fit within our strategic focus, we cannot assure you that we will be able to negotiate agreements to acquire or in-license such additional products on acceptable terms or at all. Further, if we acquire a product or
business, the process of integrating the acquired product or business may result in unforeseen operating difficulties and expenditures and may divert significant management attention from our ongoing business operations. Moreover, we may fail to
realize the anticipated benefits for a variety of reasons, such as an acquired product candidate proving to not be safe or effective in later clinical trials. We may fund any future acquisition by issuing equity or debt securities, which could
dilute the ownership percentages of our existing stockholders. Acquisition efforts can consume significant management attention and require substantial expenditures, which could detract from our other programs. In addition, we may devote resources
to potential acquisitions that are never completed.



We cannot
assure you that an acquired product or business will have the intended effect of helping us to sustain our revenue growth. If we are unable to do so, our business could be materially adversely affected.



Any of our future products may not be accepted by the market, which would harm our
business and results of operations.



Even if approved by
the FDA and other regulatory authorities, our product candidates may not achieve market acceptance by patients, prescribers and third-party payors. As a result, we may not receive revenues from these products as anticipated. The degree of market
acceptance will depend upon a number of factors, including:



| | · |  | the receipt and timing of regulatory approvals, and the scope of marketing and promotion activities permitted by such approvals (e.g., the label for the product approved
by the FDA);
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | the availability of third-party reimbursement from payors such as government health programs and private health insurers;
| | - |  | -------------------------------------------------------------------------------------------------------------------------



| | · |  | the establishment and demonstration in the medical community, such as doctors and hospital administrators, of the clinical safety, efficacy and cost-effectiveness of drug
candidates, as well as their advantages over existing treatment alternatives, if any;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | the effectiveness of the sales and marketing force that may be promoting our products; and
| | - |  | ------------------------------------------------------------------------------------------



| | · |  | the effectiveness of our contract manufacturers.
| | - |  | ------------------------------------------------



If our product candidates do not achieve market acceptance by a sufficient number of patients, prescribers and third-party payors, our business will be
materially adversely affected.



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We have limited sales and marketing infrastructure and if we are unable to develop our own sales and marketing
capability we may be unsuccessful in commercializing our products.



Under our agreement with GSK, we have the exclusive right to market and sell maribavir throughout the world, other than Japan. Under our agreement with Wyeth, we have the right to co-promote HCV products arising from our collaboration in
the U.S. and Canada. Schering-Plough is solely responsible for the marketing, promotion and sale of intranasal pleconaril following its approval.



We currently have a limited marketing staff and no sales staff. As a result of our acquisition of Vancocin, we established a small group of regional
medical scientists and commenced medical education programs, but do not anticipate that we will build a sales force related solely to Vancocin. The development of a marketing and sales capability for our product candidates in clinical development,
or for products that we may acquire if we are successful in our business development efforts, could require significant expenditures, management resources and time. We may be unable to build a marketing and sales capability, the cost of establishing
such a marketing and sales capability may exceed any product revenues, and our marketing and sales efforts may be unsuccessful. We may not be able to find a suitable sales and marketing partner for our other product candidates. If we are unable to
successfully establish a sales and marketing capability in a timely manner or find suitable sales and marketing partners, our business and results of operations will be harmed. Even if we are able to develop a sales force or find a suitable
marketing partner, we may not successfully penetrate the markets for any of our proposed products.



We depend on collaborations with third parties, which may reduce our product revenues or restrict our ability to commercialize products, and also ties our success to the success of our collaborators.



We have entered into, and may in the future enter into
additional, sales and marketing, distribution, manufacturing, development, licensing and other strategic arrangements with third parties. For example, in November 2004, we announced that we entered into a license agreement with Schering-Plough under
which Schering-Plough assumed responsibility for all future development and commercialization of pleconaril. Sanofi-Aventis also has exclusive rights to market and sell pleconaril in countries other than the U.S. and Canada for which we will receive
a royalty. Schering-Plough will receive a portion of any royalty payments made to us under our license agreement with Sanofi-Aventis for rights to pleconaril.



In August 2003, we entered into a license agreement with GSK under which we acquired exclusive worldwide rights, excluding Japan, from GSK to develop
and commercialize an antiviral compound, maribavir, for the prevention and treatment of CMV infections related to transplant, including solid organ and hematopoietic stem cell / bone marrow transplantation, congenital transmission, and in patients
with HIV infection. GSK retained the exclusive right to market and sell products covered by these patents and patent applications in Japan.



In December 1999, we entered into an agreement with Wyeth to develop jointly products for use in treating the effects of HCV in humans. Under the
agreement, we exclusively licensed to Wyeth worldwide rights under patents and know-how owned by us or created under the agreement. While we have the right to co-promote these products in the U.S. and Canada, Wyeth has the exclusive right to promote
these products elsewhere in the world, for which we will receive a royalty. Wyeth also has the exclusive right to manufacture any commercial products developed under the agreement.



If any of Wyeth, Schering-Plough or Sanofi-Aventis do not successfully market and sell products in their respective
territories, we will not receive revenue from royalties on their sales of products.



We are currently engaged in additional discussions relating to other arrangements. We cannot be sure that we will be able to enter into any such arrangements with third parties on terms acceptable to us or at all.
Third party arrangements may require us to grant certain rights to third parties, including exclusive marketing rights to one or more products, or may have other terms that are burdensome to us.



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Our ultimate success may depend upon the success of our collaborators. We have obtained from
Sanofi-Aventis and GSK, and will attempt to obtain in the future, licensed rights to certain proprietary technologies and compounds from other entities, individuals and research institutions, for which we may be obligated to pay license fees, make
milestone payments and pay royalties. In addition, we may in the future enter into collaborative arrangements for the marketing, sales and distribution of our product candidates, which may require us to share profits or revenues. We may be unable to
enter into additional collaborative licensing or other arrangements that we need to develop and commercialize our drug candidates. Moreover, we may not realize the contemplated benefits from such collaborative licensing or other arrangements. These
arrangements may place responsibility on our collaborative partners for preclinical testing, human clinical trials, the preparation and submission of applications for regulatory approval, or for marketing, sales and distribution support for product
commercialization. We cannot be certain that any of these parties will fulfill their obligations in a manner consistent with our best interests. These arrangements may also require us to transfer certain material rights or issue our equity
securities to corporate partners, licensees or others. Any license or sublicense of our commercial rights may reduce our product revenue. Moreover, we may not derive any revenues or profits from these arrangements. In addition, our current strategic
arrangements may not continue and we may be unable to enter into future collaborations. Collaborators may also pursue alternative technologies or drug candidates, either on their own or in collaboration with others, that are in direct competition
with us.



If we fail to comply with our obligations in the agreements under
which we license development or commercialization rights to products or technology from third parties, we could lose license rights that are important to our business.



Two of our current product candidates are based on intellectual property that we have licensed from Sanofi-Aventis and GSK.
Another clinical development program involves a joint development program with Wyeth pursuant to which we licensed to Wyeth worldwide rights within a certain field under patents and know-how owned by us or created under the agreement. We depend, and
will continue to depend, on these license agreements. All of our license agreements may be terminated if, among other events, we fail to satisfy our obligations as they relate to the development of the particular product candidate. All of our
license agreements, other than the agreements with Lilly regarding Vancocin, may also be terminated if we breach that license agreement and do not cure the breach within specified time periods or in the event of our bankruptcy or liquidation. Our
agreement with Lilly permits it to suspend the licenses granted to us by Lilly in the event of uncured defaults by us until such time as the default is cured or otherwise resolved.



Our license agreement with GSK imposes various obligations on us, including milestone payment requirements and royalties. If
we fail to comply with these obligations, GSK has or may have the right to terminate the license, in which event we would not be able to market products covered by the license.



Disputes may arise with respect to our licensing agreements regarding manufacturing, development and commercialization of
any of the particular product candidates. These disputes could lead to delays in or termination of the development, manufacture and commercialization of our product candidates or to litigation.



Many other entities seek to establish collaborative arrangements for product research and
development, or otherwise acquire products, in competition with us.



We face competition from large and small companies within the pharmaceutical and biotechnology industry as well as public and private research organizations, academic institutions and governmental agencies in
acquiring products and establishing collaborative arrangements for product development. Many of the companies and institutions that compete against us have substantially greater capital resources, research and development staffs and facilities than
we have, and substantially greater experience in conducting business development activities. These entities represent significant competition to us as we seek to expand further our pipeline through the in-license or acquisition of additional
products in clinical development, or that are currently on the market. Moreover, while it is not feasible to predict the actual cost of acquiring additional product candidates, that cost could be substantial. We may need additional financing in
order to acquire additional new products.



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Even if we are successful in maintaining or increasing Vancocin revenues, we may be dependent upon our ability to
raise financing for, and the successful development and commercialization of our product candidates in CMV and HCV.



We will need substantial funds to continue our business activities. We expect that Vancocin will generate significant cash flows for us and should allow
us to substantially fund our development and other operating costs under our current business plan over the next several years. We expect to incur significant expenses over at least the next several years primarily due to our development costs from
our CMV and HCV programs, business development activities seeking new opportunities to expand further our product pipeline, general and administrative expenses, and income taxes. If Vancocin revenues decrease, we may require additional capital to
continue our business activities as currently planned.



In
addition, the amount and timing of our actual capital requirements as well as our ability to finance such requirements will depend upon numerous factors, including:



| | · |  | our actual sales of Vancocin;
| | - |  | -----------------------------



| | · |  | the cost of commercializing Vancocin and our product candidates;
| | - |  | ----------------------------------------------------------------



| | · |  | our ability to generate revenue and positive cash flow through our HCV collaboration agreement with Wyeth;
| | - |  | ----------------------------------------------------------------------------------------------------------



| | · |  | whether we receive any of the additional milestone payments and royalties contemplated by our license agreement with Schering-Plough relating to development and commercialization of
intranasal pleconaril;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | the cost and progress of our clinical development programs;
| | - |  | -----------------------------------------------------------



| | · |  | the cost of milestone payments that may be due to GSK under our license agreement with them for maribavir, our product candidate to treat CMV, if pre-defined clinical and regulatory
events are achieved;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | the time and cost involved in obtaining regulatory approvals;
| | - |  | -------------------------------------------------------------



| | · |  | the cost of acquiring additional commercialized products and / or products in clinical development;
| | - |  | ---------------------------------------------------------------------------------------------------



| | · |  | the cost of filing, prosecuting, defending and enforcing any patent claims and other intellectual property rights;
| | - |  | ------------------------------------------------------------------------------------------------------------------



| | · |  | the effect of competing technological and market developments; and
| | - |  | ------------------------------------------------------------------



| | · |  | the effect of changes and developments in our existing collaborative, licensing and other relationships.
| | - |  | --------------------------------------------------------------------------------------------------------



We may be unable to generate or raise sufficient funds to complete our development, marketing and sales activities for any
of our product candidates. Potential funding sources, besides Vancocin, include:



| | · |  | public and private securities offerings;
| | - |  | ----------------------------------------



| | · |  | debt financing, such as bank loans; and
| | - |  | ---------------------------------------



| | · |  | collaborative, licensing and other arrangements with third parties.
| | - |  | -------------------------------------------------------------------



We may not be able to find sufficient debt or equity funding on acceptable terms, if at all. If we cannot, we may need to delay, reduce or eliminate
development programs, as well as other aspects of our business. The sale by us of additional equity securities or the expectation that we will sell additional equity securities may have an adverse effect on the price of our common stock. In
addition, collaborative arrangements may require us to grant product development programs or licenses to third parties for products that we might otherwise seek to develop or commercialize ourselves.



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We have a history of losses and our continued profitability is uncertain.



Prior to 2005 we had incurred losses in each year since our inception in
1994. As of December 31, 2005, we had an accumulated deficit of approximately $163.4 million. We achieved profitability for the fourth quarter ended December 31, 2004 and have maintained profitability in each of the four following
quarters. Our ability to maintain profitability is dependent on a number of factors, including continued revenues from Vancocin sales, our ability to obtain regulatory approvals for our product candidates, successfully commercializing those product
candidates, generating revenues from the sale of products from existing and potential future collaborative agreements, and securing contract manufacturing, distribution and logistics services. We do not know when or if we will acquire additional
products to expand further our product portfolio, complete our product development efforts, receive regulatory approval of any of our product candidates or successfully commercialize any approved products. We expect to incur significant additional
expenses over several years, and Vancocins ability to generate substantial cash flows over this timeframe could be materially and adversely affected by the introduction of effective generic or branded competing products. As a result, we are
unable to accurately predict whether we will be able to maintain profitability and if not, the extent of any future losses or the time required to regain profitability, if at all.



Our strategic plan may not achieve the intended results.



We restructured our business in January 2004 as part of our effort to redefine our strategic direction to focus on
development of later stage opportunities, to build specific franchises relating to our current development programs and to expand our product portfolio through the acquisition of complementary clinical development stage or commercial product
opportunities as a means to accelerate our path toward becoming a profitable pharmaceutical company. Our restructuring efforts have placed and may continue to place a significant strain on our managerial, operational, financial and other resources.



We may not be successful in executing our strategy. There are
a variety of risks and uncertainties that we face in executing this strategy.



We may need additional financing in order to acquire additional new products or product candidates. We may not have sufficient resources to execute our plans, and our actual expenses over the periods described in this
report may vary depending on a variety of factors, including:



| | · |  | the level of revenue from sales of Vancocin actually received by us;
| | - |  | --------------------------------------------------------------------



| | · |  | our actual operating costs related to Vancocin;
| | - |  | -----------------------------------------------



| | · |  | the cost of acquiring additional new product opportunities as a result of our business development efforts;
| | - |  | -----------------------------------------------------------------------------------------------------------



| | · |  | the actual cost of conducting clinical trials;
| | - |  | ----------------------------------------------



| | · |  | the outcome of clinical trials in our CMV and HCV programs;
| | - |  | -----------------------------------------------------------



| | · |  | whether we receive any of the milestone payments and royalties contemplated by our license agreement with Schering-Plough relating to the development and commercialization of
intranasal pleconaril; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | our resulting right to receive or obligation to pay milestone payments under agreements relating to our CMV, HCV and common cold programs.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------



In addition to the points noted above, our ability to sustain profitability
is dependent on developing and obtaining regulatory approvals for our product candidates, successfully commercializing such product candidates, which may include entering into collaborative agreements for product development and commercialization,
acquiring additional products through our business development efforts, and securing contract manufacturing services and distribution and logistics services. If our sales of Vancocin are materially adversely affected because of competition or other
reasons, we may need to raise substantial additional funds to continue our business activities as currently planned.



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We will rely on our employees, consultants, contractors, suppliers, manufacturers and collaborators to keep our trade
secrets confidential.



We rely on trade secrets,
trademarks, and unpatented proprietary know-how and continuing technological innovation in developing and manufacturing our products, including Vancocin, in order to protect our significant investment in these products from the risk of discovery by
generic drug manufacturers and other potential competition. We require each of our employees, consultants, advisors, contractors, suppliers, manufacturers and collaborators to enter into confidentiality agreements prohibiting them from taking our
proprietary information and technology or from using or disclosing proprietary information to third parties except in specified circumstances. The agreements also provide that all inventions conceived by an employee, consultant or advisor, to the
extent appropriate for the services provided during the course of the relationship, are our exclusive property, other than inventions unrelated to us and developed entirely on the individuals own time. Nevertheless, these agreements may not
provide meaningful protection of our trade secrets and proprietary know-how if they are used or disclosed. Despite all of the precautions we may take, people who are not parties to confidentiality agreements may obtain access to our trade secrets or
know-how. In addition, others may independently develop similar or equivalent trade secrets or know-how.



We depend on patents and proprietary rights for our products which are in clinical development, which may offer only limited protection against potential infringement, and if we are unable to protect our patents
and proprietary rights, we may lose the right to develop, manufacture, market or sell products and lose sources of revenue.



The pharmaceutical industry places considerable importance on obtaining patent and trade secret protection for new technologies, products and processes.
Our success depends, in part, on our ability to develop and maintain a strong patent position for our products and technologies in clinical development, both in the U.S. and in other countries. Litigation or other legal proceedings may be necessary
to defend against claims of infringement, to enforce our patents, or to protect our trade secrets, and could result in substantial cost to us and diversion of our efforts. We intend to file applications as appropriate for patents describing the
composition of matter of our drug candidates, the proprietary processes for producing such compositions, and the uses of our drug candidates. We own four issued U.S. patents, two non-U.S. patents and have eleven pending U.S. patent applications, six
of which we co-own with Wyeth. We also have filed international, regional and non-U.S. national patent applications in order to pursue patent protection in major foreign countries.



Many of our scientific and management personnel were previously employed by competing companies. As a result, such companies
may allege trade secret violations and similar claims against us.



To facilitate development of our proprietary technology base, we may need to obtain licenses to patents or other proprietary rights from other parties. If we are unable to obtain such licenses, our product development efforts may be
delayed. We may collaborate with universities and governmental research organizations which, as a result, may acquire certain rights to any inventions or technical information derived from such collaboration.



We may incur substantial costs in asserting any patent rights and in
defending suits against us related to intellectual property rights, even if we are ultimately successful. If we are unsuccessful in defending a claim that we have infringed or misappropriated the intellectual property of a third party, we could be
required to pay substantial damages, stop using the disputed technology, develop new non-infringing technologies, or obtain one or more licenses from third parties. If we or our licensors seek to enforce our patents, a court may determine that our
patents or our licensors patents are invalid or unenforceable, or that the defendants activity is not covered by the scope of our patents or our licensors patents. The U.S. Patent and Trademark Office or a private party could
institute an interference proceeding relating to our patents or patent applications. An opposition or revocation proceeding could be instituted in the patent offices of foreign jurisdictions. An adverse decision in any such proceeding could result
in the loss of our rights to a patent or invention.



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If our licensors do not protect our rights under our license agreements with them or do not reasonably consent to our
sublicense of rights or if these license agreements are terminated, we may lose revenue and expend significant resources defending our rights.



We have licensed from GSK worldwide rights, excluding Japan, to an antiviral compound, maribavir, for the prevention and treatment of CMV infections
related to transplant, including solid organ and hematopoietic stem cell/bone marrow transplantation, congenital transmission, and in patients with HIV infection. This compound, and a related compound, are subject to patents and patent applications
in a variety of countries throughout the world. We have licensed from Sanofi-Aventis the exclusive U.S. and Canadian rights to certain antiviral agents for use in picornavirus indications, which are the subject of U.S. and Canadian patents and
patent applications owned by Sanofi-Aventis, certain of which describe pleconaril and others of which describe compounds that are either related to pleconaril or have antiviral activity. We sublicensed our rights under these patents to
Schering-Plough. We depend on GSK and Sanofi-Aventis to prosecute and maintain many of these patents and patent applications and protect such patent rights. Failure by GSK or Sanofi-Aventis to prosecute or maintain such patents or patent
applications and protect such patent rights could lead to our loss of revenue. Under certain circumstances, our ability to sublicense our rights under these license agreements is subject to the licensors consent. If our license agreements with
GSK and Sanofi-Aventis are terminated, our ability to manufacture, develop, market and sell products under those agreements would terminate.



Our successful commercialization of our products will depend, in part, on the availability and adequacy of third party reimbursement.



Our ability to commercialize our product candidates successfully will
depend, in part, on the extent to which reimbursement for the cost of such products and related treatments will be available from government health administration authorities, such as Medicare and Medicaid in the U.S., private health insurers and
other organizations. Federal and state regulations govern or influence the reimbursement to health care providers of fees in connection with medical treatment of certain patients. In the U.S., there have been, and we expect there will continue to
be, a number of state and federal proposals that could limit the amount that state or federal governments will pay to reimburse the cost of drugs. Continued significant changes in the health care system could have a material adverse effect on our
business. Decisions by state regulatory agencies, including state pharmacy boards, and/or retail pharmacies may require substitution of generic for branded products, may prefer competitors products over our own, and may impair our pricing and
thereby constrain our market share and growth. In addition, we believe the increasing emphasis on managed care in the U.S. could put pressure on the price and usage of our product candidates, which may in turn adversely impact future product sales.



Significant uncertainty exists as to the reimbursement status
of newly approved health care products, particularly for indications for which there is no current effective treatment or for which medical care typically is not sought. Adequate third-party coverage may not be available to enable us to maintain
price levels sufficient to realize an appropriate return on our investment in product development. If adequate coverage and reimbursement levels are not provided by government and third-party payors for use of our products, our products may fail to
achieve market acceptance and we could lose anticipated revenues and experience delayed achievement of profitability.



In recent years, various legislative proposals have been offered in the U.S. Congress and in some state legislatures that include major changes in the
health care system. These proposals have included price or patient reimbursement constraints on medicines and restrictions on access to certain products. We cannot predict the outcome of such initiatives, and it is difficult to predict the future
impact of the broad and expanding legislative and regulatory requirements affecting us.



We depend on key personnel and may not be able to retain these employees or recruit additional qualified personnel, which would harm our ability to compete.



We are highly dependent upon qualified scientific, technical and managerial personnel, including our President and CEO,
Michel de Rosen, our Vice President, Chief Operating Officer and Chief Financial Officer,



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Vincent J. Milano, our Vice President and Chief Scientific Officer, Colin Broom, and our Vice President and Chief Commercial Officer, Joshua Tarnoff. Our
ability to grow and expand into new areas and activities will require additional expertise and the addition of new qualified personnel. There is intense competition for qualified personnel in the pharmaceutical field. Therefore, we may not be able
to attract and retain the qualified personnel necessary for the development of our business. Furthermore, we have not entered into non-competition agreements or employment agreements with our key employees. The loss of the services of existing
personnel, as well as the failure to recruit additional key scientific, technical and managerial personnel in a timely manner, would harm our development programs, and our ability to manage day-to-day operations, attract collaboration partners,
attract and retain other employees and generate revenues. We do not maintain key man life insurance on any of our employees.



We may be subject to product liability claims, which can be expensive, difficult to defend and may result in large judgments or settlements against us.



The administration of drugs to humans, whether in clinical trials or
after marketing clearance is obtained, can result in product liability claims. Product liability claims can be expensive, difficult to defend and may result in large judgments or settlements against us. In addition, third party collaborators and
licensees may not protect us from product liability claims.



We
currently maintain product liability insurance in connection with our clinical development programs and marketing of Vancocin. We may not be able to obtain or maintain adequate protection against potential liabilities arising from clinical
development or product sales. If we are unable to obtain sufficient levels of insurance at acceptable cost or otherwise protect against potential product liability claims, we will be exposed to product liability claims. A successful product
liability claim in excess of our insurance coverage could harm our financial condition, results of operations and prevent or interfere with our product commercialization efforts. In addition, any successful claim may prevent us from obtaining
adequate product liability insurance in the future on commercially desirable terms. Even if a claim is not successful, defending such a claim may be time-consuming and expensive.



We previously used hazardous materials in our business and any claims relating to improper handling, storage or disposal of these
materials could be time consuming and costly.



Prior to
our restructuring in January 2004, we used radioactive and other materials that could be hazardous to human health, safety or the environment. In connection with our restructuring in January 2004, we decommissioned our discovery laboratories, which
required the disposal of many of these materials. We are subject to stringent federal, state and local laws, rules, regulations and policies governing the use, generation, manufacture, storage, air emission, effluent discharge, handling and disposal
of certain materials and wastes. We stored these materials and various wastes resulting from their use at our facility pending ultimate use and disposal. Although we believe that our safety procedures for handling and disposing of such materials
comply with federal, state and local laws, rules, regulations and policies, the risk of accidental injury or contamination from these materials cannot be entirely eliminated. We may be required to incur significant costs to comply with environmental
laws, rules, regulations and policies. Additionally, if an accident occurs, we could be held liable for any resulting damages, and any such liability could exceed our resources. We do not maintain a separate insurance policy for these types of risks
and we do not have reserves set aside for environmental claims. Any future environmental claims could harm our financial conditions, results of operations, liquidity and prevent or interfere with our product commercialization efforts. In addition,
compliance with future environmental laws, rules, regulations and policies could lead to additional costs and expenses.



The rights that have been and may in the future be granted to holders of our common or preferred stock may adversely affect the rights of other stockholders and may
discourage a takeover.



Our board of directors has the
authority to issue up to 4,800,000 shares of preferred stock and to determine the price, privileges and other terms of such shares. Our board of directors may exercise this authority without



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the approval of, or notice to, our stockholders. Accordingly, the rights of the holders of our common stock may be adversely affected by the rights of the
holders of any preferred stock that may be issued in the future. In addition, the issuance of preferred stock may make it more difficult for a third party to acquire a majority of our outstanding voting stock in order to effect a change in control
or replace our current management. We are also subject to the anti-takeover provisions of Section 203 of the Delaware General Corporation Law. The application of Section 203 could also delay or prevent a third party or a significant
stockholder of ours from acquiring control of us or replacing our current management. In general, Section 203 prohibits a publicly held Delaware corporation from engaging in a business combination with an interested stockholder for a period of
three years following the date the person became an interested stockholder, unless the business combination or the transaction in which the person became an interested stockholder is approved in a prescribed manner. Generally, a business combination
includes a merger, asset or stock sale, or other transaction resulting in a financial benefit to the interested stockholder. Under Delaware law, an interested stockholder is a person who, together with affiliates and associates, owns 15% or more of
a corporations voting stock.



In September 1998, our
board of directors adopted a plan that grants each holder of our common stock the right to purchase shares of our series A junior participating preferred stock. This plan is designed to help insure that all our stockholders receive fair value for
their shares of common stock in the event of a proposed takeover of us, and to guard against the use of partial tender offers or other coercive tactics to gain control of us without offering fair value to the holders of our common stock. In
addition, our charter and bylaws contain certain provisions that could discourage a hostile takeover, such as a staggered board of directors and significant notice provisions for nominations of directors and proposals. The plan and our charter and
bylaws may make it more difficult for a third party to acquire a majority of our outstanding voting stock in order to effect a change in control or replace our current management.



Our stock price could continue to be volatile.



Our stock price, like the market price of the stock of other pharmaceutical companies, has been volatile. For example,
during the year ended December 31, 2005, the market price for our common stock fluctuated between $1.67 and $24.36 per share. The following factors, among others, could have a significant impact on the market for our common stock:



| | · |  | period to period fluctuations in sales of Vancocin;
| | - |  | ---------------------------------------------------



| | · |  | results of clinical trials with respect to our product candidates in development or those of our competitors;
| | - |  | -------------------------------------------------------------------------------------------------------------



| | · |  | developments with our collaborators;
| | - |  | ------------------------------------



| | · |  | announcements of technological innovations or new products by our competitors;
| | - |  | ------------------------------------------------------------------------------



| | · |  | litigation or public concern relating to our products or our competitors products;
| | - |  | -----------------------------------------------------------------------------------



| | · |  | developments in patent or other proprietary rights of ours or our competitors (including related litigation);
| | - |  | -------------------------------------------------------------------------------------------------------------



| | · |  | any other future announcements concerning us or our competitors;
| | - |  | ----------------------------------------------------------------



| | · |  | any announcement regarding our acquisition of product candidates or entities;
| | - |  | -----------------------------------------------------------------------------



| | · |  | future announcements concerning our industry;
| | - |  | ---------------------------------------------



| | · |  | governmental regulation;
| | - |  | ------------------------



| | · |  | actions or decisions by the SEC, the FDA or other regulatory agencies;
| | - |  | ----------------------------------------------------------------------



| | · |  | changes or announcements of changes in reimbursement policies;
| | - |  | --------------------------------------------------------------



| | · |  | period to period fluctuations in our operating results, including changes in accounting estimates;
| | - |  | --------------------------------------------------------------------------------------------------



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| | · |  | our cash and cash equivalents balances;
| | - |  | ---------------------------------------



| | · |  | changes in our capital structure;
| | - |  | ---------------------------------



| | · |  | changes in estimates of our performance by securities analysts;
| | - |  | ---------------------------------------------------------------



| | · |  | market conditions applicable to our business sector; and
| | - |  | --------------------------------------------------------



| | · |  | general market conditions.
| | - |  | --------------------------



Future sales of our common stock in the public market could adversely affect our stock price.



We cannot predict the effect, if any, that future sales of our common stock or the availability for future sale of shares of our common stock or
securities convertible into or exercisable for our common stock will have on the market price of our common stock prevailing from time to time. We have an effective registration statement on Form S-3 which allows us to sell up to $39 million of
securities in one or more public offerings. The registration statement provides us with the flexibility to determine the type of security we choose to sell, including common stock, preferred stock, warrants and debt securities, as well as the
ability to time such sales when market conditions are favorable. Additionally, we have another effective registration statement on Form S-3 which permits the holders of up to 33.8 million shares of our common stock received upon conversion of
our senior convertible notes to resell these shares from time to time.



As of December 31, 2005 we had outstanding options to purchase 3,006,131 shares of our common stock at a weighted average exercise price of $8.03 per share (1,748,212 of which have not yet vested) issued to employees, directors and
consultants pursuant to our 1995 Stock Option and Restricted Share Plan, outstanding options to purchase 42,000 shares of our common stock at a weighted average exercise price of $19.49 per share (42,000 of which have not yet vested) issued to
employees, directors and consultants pursuant to our 2005 Stock Option and Restricted Share Plan and outstanding options to purchase 86,074 shares of our common stock at a weighted average exercise price of $1.40 per share (19,248 of which have not
yet vested) to non-executive employees pursuant to our 2001 Equity Incentive Plan. In order to attract and retain key personnel, we may issue additional securities, including stock options, restricted stock grants and shares of common stock, in
connection with our employee benefit plans, or may lower the price of existing stock options. Sale, or the availability for sale, of substantial amounts of common stock by our existing stockholders pursuant to an effective registration statement or
under Rule 144, through the exercise of registration rights or the issuance of shares of common stock upon the exercise of stock options or warrants, or the perception that such sales or issuances could occur, could adversely affect the prevailing
market prices for our common stock.



|ITEM 1B.    UNRESOLVED | STAFF COMMENTS
|---------------------- | --------------



None.



|ITEM 2.    PROPERTIES | 
|--------------------- | 



We currently lease 33,000 square feet in a facility located in Exton, Pennsylvania for our corporate and development activities under an operating lease expiring in 2017.



|ITEM 3.    LEGAL | PROCEEDINGS
|---------------- | -----------



None.



|ITEM 4.    SUBMISSION | OF MATTERS TO A VOTE OF SECURITY HOLDERS
|--------------------- | ----------------------------------------



None.



34



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##### Table of Contents

PART II



|ITEM 5. | MARKET FOR THE REGISTRANTS COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES
|------- | ----------------------------------------------------------------------------------------------------------------



Market Information



Our common stock is traded on the National Market segment of The Nasdaq Stock Market under the symbol VPHM. We
commenced trading on The Nasdaq Stock Market on November 19, 1996. The following table sets forth the high and low sale prices as quoted on The Nasdaq Stock Market for each quarter of 2004 and 2005 and through February 24, 2006.



|                                               |  |      |       |     |   |      
|---------------------------------------------- |  | ---- | ----- | --- | - | -----
|                                               |  | High |       | Low
|Year ended December 31, 2004                   |  |      |       |     |   |      
|First Quarter                                  |  | $    | 3.74  |     | $ | 2.24 
|Second Quarter                                 |  | $    | 2.75  |     | $ | 1.46 
|Third Quarter                                  |  | $    | 2.61  |     | $ | 1.40 
|Fourth Quarter                                 |  | $    | 3.52  |     | $ | 1.78 
|                                               |  |     
|Year ended December 31, 2005                   |  |      |       |     |   |      
|First Quarter                                  |  | $    | 3.49  |     | $ | 2.15 
|Second Quarter                                 |  | $    | 7.37  |     | $ | 1.67 
|Third Quarter                                  |  | $    | 21.35 |     | $ | 6.57 
|Fourth Quarter                                 |  | $    | 24.36 |     | $ | 15.56
|                                               |  |     
|First Quarter 2006 (through February 24, 2006) |  | $    | 23.44 |     | $ | 17.77



Holders and Dividends



There were approximately 696 record holders of our common
stock as of February 24, 2006. We have never declared or paid any cash dividends on our common stock. We have declared and paid dividends in the past on our previously outstanding series A convertible participating preferred stock. As of
February 24, 2006, we had no shares of preferred stock outstanding. Any future determination to pay dividends will be at the discretion of our board of directors and will be dependent on then existing conditions, including our financial
condition, results of operations, contractual restrictions, capital requirements, business and other factors our board of directors deems relevant.



35



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##### Table of Contents

|ITEM 6. | SELECTED FINANCIAL DATA
|------- | -----------------------



The selected financial data presented below under the caption Consolidated Statement of Operations Data for the years ended December 31,
2005, 2004, 2003, 2002 and 2001 and under the caption Consolidated Balance Sheet Data as of December 31, 2005, 2004, 2003, 2002 and 2001 are derived from our consolidated financial statements which have been audited. The data set
forth below should be read in conjunction with Managements Discussion and Analysis of Financial Condition and Results of Operations, the Consolidated Financial Statements and the notes thereto and the other financial information included
elsewhere in this Report.



In November 2004, we acquired all
rights in the U.S. and its territories to manufacture market and sell Vancocin, as well as rights to certain related vancomycin products, from Eli Lilly and Company (Lilly). See Note 9 of the Consolidated Financial Statements.



|                                                                                 |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|-------------------------------------------------------------------------------- |  | ----------------------- | ------- | - | ---- | - | ------- | ---- |  | - | ------- | - |  | ---- | ------- | - |  | - | ------- | -
|                                                                                 |  | Year Ended December 31, |        
|                                                                                 |  | 2005                    |         |   | 2004 |   |         | 2003 |  |   | 2002    |   |  | 2001 |        
|(in thousands, except per share amounts)                                         |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |        
|Consolidated Statement of Operations Data:                                       |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Net product sales                                                                |  | $                       | 125,853 |   |      | $ | 8,348   |      |  | $ |        |   |  | $    |        |   |  | $ |        |  
|                                                                                 |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Total revenues                                                                   |  |                         | 132,417 |   |      |   | 22,389  |      |  |   | 1,612   |   |  |      | 5,537   |   |  |   | 3,385   |  
|Operating expenses:                                                              |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Cost of sales                                                                    |  |                         | 18,029  |   |      |   | 1,717   |      |  |   |        |   |  |      |        |   |  |   |        |  
|Research and development                                                         |  |                         | 10,610  |   |      |   | 16,388  |      |  |   | 23,043  |   |  |      | 39,823  |   |  |   | 43,013  |  
|Marketing, general and administrative                                            |  |                         | 10,475  |   |      |   | 15,643  |      |  |   | 9,035   |   |  |      | 14,626  |   |  |   | 23,055  |  
|Intangible amortization and acquisition of technology rights                     |  |                         | 5,158   |   |      |   | 650     |      |  |   | 3,500   |   |  |      |        |   |  |   | 16,500  |  
|                                                                                 |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Total operating expenses                                                         |  |                         | 44,272  |   |      |   | 34,398  |      |  |   | 35,578  |   |  |      | 54,449  |   |  |   | 82,568  |  
|Operating income (loss)                                                          |  |                         | 88,145  |   |      |   | (12,009 | )    |  |   | (33,966 | ) |  |      | (48,912 | ) |  |   | (79,183 | )
|Interest income                                                                  |  |                         | 2,008   |   |      |   | 1,080   |      |  |   | 1,829   |   |  |      | 5,429   |   |  |   | 12,322  |  
|Interest (expense)                                                               |  |                         | (11,304 | ) |      |   | (10,320 | )    |  |   | (8,438  | ) |  |      | (11,034 | ) |  |   | (11,620 | )
|Income tax expense (benefit)                                                     |  |                         | (37,805 | ) |      |   |        |      |  |   |        |   |  |      |        |   |  |   |        |  
|                                                                                 |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Net income (loss) from continuing operations                                     |  | $                       | 113,705 |   |      | $ | (19,534 | )    |  | $ | (36,942 | ) |  | $    | (26,623 | ) |  | $ | (78,481 | )
|Net income (loss) per share from continuing operations:                          |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Basic                                                                            |  | $                       | 2.56    |   |      | $ | (0.73   | )    |  | $ | (1.43   | ) |  | $    | (1.11   | ) |  | $ | (4.32   | )
|Diluted                                                                          |  | $                       | 2.02    |   |      | $ | (0.73   | )    |  | $ | (1.43   | ) |  | $    | (1.11   | ) |  | $ | (4.32   | )
|                                                                                 |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Shares used in computing net income (loss) from continuing operations per share: |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Basic                                                                            |  |                         | 44,334  |   |      |   | 26,578  |      |  |   | 25,916  |   |  |      | 23,953  |   |  |   | 18,167  |  
|Diluted                                                                          |  |                         | 57,610  |   |      |   | 26,578  |      |  |   | 25,916  |   |  |      | 23,953  |   |  |   | 18,167  |  
|                                                                                 | 
|                                                                                 |  | As of December 31,      |        
|                                                                                 |  | 2005                    |         |   | 2004 |   |         | 2003 |  |   | 2002    |   |  | 2001 |        
|Consolidated Balance Sheet Data:                                                 |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Cash, cash equivalents and short-term investments (1)                            |  | $                       | 233,413 |   |      | $ | 44,210  |      |  | $ | 121,148 |   |  | $    | 158,282 |   |  | $ | 240,040 |  
|Working capital                                                                  |  |                         | 166,666 |   |      |   | 42,918  |      |  |   | 113,096 |   |  |      | 152,772 |   |  |   | 220,621 |  
|Total assets                                                                     |  |                         | 435,525 |   |      |   | 178,360 |      |  |   | 133,458 |   |  |      | 173,531 |   |  |   | 266,181 |  
|Long-term debt (2)                                                               |  |                         |        |   |      |   | 190,400 |      |  |   | 127,900 |   |  |      | 134,908 |   |  |   | 180,125 |  
|Total stockholders equity (deficit)                                             |  |                         | 326,977 |   |      |   | (26,138 | )    |  |   | (7,509  | ) |  |      | 27,811  |   |  |   | 39,430  |  

---

|(1) |  | Cash, cash equivalents and short-term investments includes $9.0 million in restricted cash at December 31, 2004, which became unrestricted in 2005.
|--- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------

|(2) |  | Of the $190.4 million of long-term debt that were outstanding at December 31, 2004, $78.9 million was outstanding as of December 31, 2005. The subordinated convertible
notes are reported as a current obligation, a component of working capital, since, as of December 31, 2005, it was the Companys intent to redeem these notes the first quarter of 2006. See Note 8 of the Consolidated Financial Statements.
|--- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



The Company has never paid dividends on common
stock.



36



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##### Table of Contents

|ITEM 7.    MANAGEMENTS | DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND  RESULTS OF OPERATION
|----------------------- | ------------------------------------------------------------------------



Background



We are a biopharmaceutical company dedicated to the development and commercialization of products that address serious diseases. We have a core expertise
in the area of infectious diseases and are committed to focusing our commercialization and development programs on products used by physician specialists or in hospital settings. We intend to grow through sales of our marketed product, Vancocin® capsules HCl, and through the continued development of
our product pipeline and potential acquisition of products or companies.



We have one marketed product and multiple product candidates in clinical development. We market and sell Vancocin capsules HCl, the oral capsule formulation of vancomycin hydrochloride, in the U.S. and its
territories. Vancocin is a potent antibiotic approved by the U.S. Food and Drug Administration, or FDA, to treat antibiotic-associated pseudomembranous colitis caused by Clostridium difficile, or C. difficile, and enterocolitis caused
by S. aureus, including methicillin-resistant strains. We are developing maribavir for the treatment of cytomegalovirus, or CMV, infection, and HCV-796 for the treatment of hepatitis C virus, or HCV, infection. We have licensed the U.S. and
Canadian rights for a third product candidate, an intranasal formulation of pleconaril, to Schering-Plough for the treatment of picornavirus infections.



We intend to continue to evaluate in-licensing or other means of acquiring products in clinical development, and marketed products, in order to expand our
current portfolio. Such products may be intended to treat, or are currently used to treat, the patient populations treated by physician specialists or in hospital settings.



During the year ended December 31, 2005, we were profitable from operations and ended the period with $233.4 million in
cash, cash equivalents and short-term investments. The fourth quarter represents the fifth consecutive quarter during which we were profitable and the fourth quarter in our history that we were profitable primarily as a result of product sales.



During 2005, we raised an additional $12.5 million of debt and
reduced our debt by $124.0 million to $78.9 million. On March 1, 2006, we redeemed the remaining $78.9 million principal amount of subordinated convertible notes, which eliminated all long-term debt that was outstanding at December 31,
2005. We have an accumulated deficit of $163.4 million at December 31, 2005. Prior to the acquisition of Vancocin, our first commercial product, we incurred historical losses. Historical losses resulted principally from costs incurred in
research and development activities, write-off of acquired technology rights, general and administrative expenses, interest payments on our outstanding debt and sales and marketing expenses.



Executive Summary



During 2005, we experienced the following:



Business Activities



Vancocin:



| | · |  | Entered into supply chain agreements.
| | - |  | -------------------------------------



| | · |  | Expanded manufacturing capabilities.
| | - |  | ------------------------------------



| | · |  | Built inventory to levels we believe necessary to service customers in the near term.
| | - |  | -------------------------------------------------------------------------------------



| | · |  | Initiated a medical education program.
| | - |  | --------------------------------------



| | · |  | Launched a regional medical scientist team.
| | - |  | -------------------------------------------



37



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##### Table of Contents

CMV:



| | · |  | Completed a phase 1 clinical trial with maribavir to evaluate the potential for drug interactions.
| | - |  | --------------------------------------------------------------------------------------------------



| | · |  | Initiated and completed a phase 1 clinical trial to evaluate the pharmacokinetics of maribavir in subjects with hepatic impairment.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------



| | · |  | Initiated and completed a phase 1 clinical trial to evaluate the relative bioavailability of different tablet formulations of maribavir.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------



| | · |  | Completed enrollment in a phase 2 clinical trial with maribavir for the prevention of CMV infections in allogeneic stem cell transplant recipients.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------



HCV (with our partner Wyeth):



| | · |  | Announced that phase 1 clinical data for the compound HCV-086 did not support further development of that compound.
| | - |  | -------------------------------------------------------------------------------------------------------------------



| | · |  | Initiated and completed a phase 1 clinical trial with HCV-796 in healthy subjects.
| | - |  | ----------------------------------------------------------------------------------



| | · |  | Initiated and reported promising preliminary results from a phase 1b proof of concept dose ranging clinical trial with HCV-796 in hepatitis C infected patients.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------



Operating Results



| | · |  | Increased demand of Vancocin due to increased prescriptions, as compared to 2004.
| | - |  | ---------------------------------------------------------------------------------



| | · |  | Realized effects of price increases.
| | - |  | ------------------------------------



| | · |  | Released a portion of our deferred income tax valuation allowance.
| | - |  | ------------------------------------------------------------------



Liquidity



| | · |  | Reduced debt principal by $124.0 million through repurchases and conversions.
| | - |  | -----------------------------------------------------------------------------



| | · |  | Raised $163.5 million of net proceeds through the issuance of 10,350,000 shares of common stock.
| | - |  | ------------------------------------------------------------------------------------------------



| | · |  | Generated net cash from operating activities of $71.5 million.
| | - |  | --------------------------------------------------------------



In 2006 and going forward, we expect to face a number of challenges, which include the following:



The commercial sale of approved pharmaceutical products is subject to risks
and uncertainties. There can be no assurance that future Vancocin sales will meet or exceed the historical rate of sales for the product, for reasons that include, but are not limited to, generic and non-generic competition for Vancocin and/or
changes in prescribing habits.



We will face intense
competition in acquiring additional products to expand further our product portfolio. Many of the companies and institutions that we will compete with in acquiring additional products to expand further our product portfolio have substantially
greater capital resources, research and development staffs and facilities than we have, and substantially greater experience in conducting business development activities. We may need additional financing in order to acquire new products in
connection with our plans as described in this report.



We
cannot be certain that we will be successful in developing and ultimately commercializing any of our product candidates.



There can be no assurance that cash flows from Vancocin sales will be sufficient to fund all of our ongoing development and operational costs over the
next several years, that planned clinical trials can be initiated, or that



38



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##### Table of Contents

planned or ongoing clinical trials can be successfully concluded or concluded in accordance with our anticipated schedule and costs. Moreover, the results of
our business development efforts could require considerable investments.



Our actual results could differ materially from those results expressed in, or implied by, our expectations and assumption described in this Annual Report on Form 10-K. Please also see our discussion of the Risk
Factors in Item 1A, which describe other important matters relating our business.



Recent Events



Issuance of
10,350,000 Shares of Common Stock



In December 2005, we
sold 10,350,000 shares of newly issued common stock at $16.75 per share in a public offering. The net proceeds, after underwriting discounts, commissions and other fees, were $163.5 million. The shares included the offering of 9,000,000 shares and
the exercise by the underwriters of their option to purchase an additional 1,350,000 shares of common stock.



Vancocin CapsulesAmended Manufacturing Agreement



In connection with the acquisition, we entered into a supply agreement with Eli Lilly and Company (Lilly) for the manufacture and supply of the active pharmaceutical ingredient (API) of Vancocin as well as
the Vancocin finished product for an agreed upon time period. In November 2005, we amended our manufacturing agreement with Lilly which, among other things, increased the amount of Vancocin that Lilly supplied to us during 2005, for which we agreed
to pay up to an additional $4.5 million, and ensured that Lilly continues to supply us with Vancocin until at least September 30, 2006. That date will be extended to a later date if our third party supply chain is not qualified by
September 30, 2006. The process of qualifying a third party supply chain is now ongoing. Lilly supplied the agreed upon increased product volume in 2005. The additional $4.5 million increased inventory costs and will increase our cost of sales
for these specific units.



Debt Reductions



On January 1, 2005, we had $190.4 million of long-term debt. By
December 31, 2005, we had reduced that debt to $78.9 million. On March 1, 2006, we redeemed the remaining $78.9 million principal amount of subordinated convertible notes, which eliminated all long-term debt that was outstanding at
December 31, 2005. The table below summarizes the activity of our long-term debt principal during 2005:



|                            |  |                              |         |   |             |   |         |                        |  |   |                     |   |  |   |         |  
|--------------------------- |  | ---------------------------- | ------- | - | ----------- | - | ------- | ---------------------- |  | - | ------------------- | - |  | - | ------- | -
|                            |  | ConvertibleSubordinatedNotes |         |   | SeniorNotes |   |         | SeniorConvertibleNotes |  |   | Total DebtPrincipal |  
|January 1, 2005             |  | $                            | 127,900 |   |             | $ | 62,500  |                        |  | $ |                    |   |  | $ | 190,400 |  
|Exchange                    |  |                              |        |   |             |   | (62,500 | )                      |  |   | 62,500              |   |  |   |        |  
|Exercise of purchase option |  |                              |        |   |             |   |        |                        |  |   | 12,500              |   |  |   | 12,500  |  
|Repurchases                 |  |                              | (48,980 | ) |             |   |        |                        |  |   |                    |   |  |   | (48,980 | )
|Voluntary conversions       |  |                              |        |   |             |   |        |                        |  |   | (40,800             | ) |  |   | (40,800 | )
|Automatic conversions       |  |                              |        |   |             |   |        |                        |  |   | (34,200             | ) |  |   | (34,200 | )
|                            |  |                              |         |   |             |   |         |                        |  |   |                     |   |  |   |         |  
|December 31, 2005           |  | $                            | 78,920  |   |             | $ |        |                        |  | $ |                    |   |  | $ | 78,920  |  
|                            |  |                              |         |   |             |   |         |                        |  |   |                     |   |  |   |         |  



The table above
summarizes complex transactions that had material impacts on our results of operations, including net income, cash flow and stockholders equity. The table above does not include amounts related to derivative accounting. See Note 8 of the
Consolidated Financial Statements, Results of Operations and Liquidity for the full financial impact and detailed information.



39



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##### Table of Contents

Vancocin CapsulesContingent Consideration



In November 2004, we acquired all rights in the U.S. and its territories to manufacture, market and sell Vancocin, as well
as rights to certain related vancomycin products, from Lilly. We paid Lilly an upfront cash payment of $116.0 million. During 2005, we were obligated to pay Lilly additional purchase price consideration equal to 50% of our net sales of Vancocin
between $44 million and $65 million. We surpassed the maximum level of $65 million of net sales of Vancocin during 2005 and paid Lilly additional consideration of $10.5 million. We will pay additional amounts based on annual net sales of Vancocin as
set forth below:



|                  |  |                                                
|----------------- |  | -----------------------------------------------
|2006              |  | 35% payment on net sales between $46-65 million
|2007              |  | 35% payment on net sales between $48-65 million
|2008 through 2011 |  | 35% payment on net sales between $45-65 million



No additional payments
are due to Lilly on net sales of Vancocin below or above the net sales levels reflected in the above table. We will account for the future additional payments as contingent consideration and record an adjustment to the carrying amount of the related
intangible assets and a cumulative adjustment to the intangible amortization upon achievement of the related sales milestones. Assuming the maximum threshold is met at the end of each year, the cumulative amortization adjustment would be $0.6
million, $0.7 million and $1.2 million in the years ended December 31, 2006, 2007 and 2008, respectively. See Note 6 of the Consolidated Financial Statements for additional information on the intangible assets and amortization.



Pleconaril / Schering-Plough Corporation



In November 2004, we entered into a license agreement with Schering-Plough
under which Schering-Plough has assumed responsibility for all future development and commercialization of pleconaril in the U.S. and Canada. Schering-Plough paid us an upfront option fee of $3.0 million in November 2003. In August 2004,
Schering-Plough exercised its option to enter into a full license agreement with us following its assessment of the products performance in characterization studies. Schering-Plough paid us an initial license fee of $10.0 million in December
2004 and purchased our inventory of bulk drug substance for an additional $6.0 million in January 2005. We are also eligible to receive up to an additional $65.0 million in milestone payments upon achievement of certain targeted regulatory and
commercial events, as well as royalties on Schering-Ploughs sales of intranasal pleconaril in the licensed territories. Schering-Plough is now responsible for the development and commercialization of the intranasal formulation of pleconaril
for the treatment of the common cold. Sanofi-Aventis has exclusive rights to market and sell pleconaril in countries other than the U.S. and Canada.



Results of Operations



Years ended December 31, 2005 and 2004



|                             |  |                                 |         |      |   |         |  
|---------------------------- |  | ------------------------------- | ------- | ---- | - | ------- | -
|                             |  | For the years endedDecember 31, |        
|                             |  | 2005                            |         | 2004 |  
|(in thousands)               |  |                                 |         |      |  
|Net product sales            |  | $                               | 125,853 |      | $ | 8,348   |  
|Total revenues               |  | $                               | 132,417 |      | $ | 22,389  |  
|Gross margin                 |  | $                               | 107,824 |      | $ | 6,631   |  
|Net income (loss)            |  | $                               | 113,705 |      | $ | (19,534 | )
|                             |  |                                
|Net income (loss) per share: |  |                                 |         |      |   |         |  
|Basic                        |  | $                               | 2.56    |      | $ | (0.73   | )
|Diluted                      |  | $                               | 2.02    |      | $ | (0.73   | )



The improvement in net
operating results of $133.2 million was due primarily to gross margin (net product sales less cost of sales) provided by Vancocin net product sales represented above, and the income tax benefit of



40



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##### Table of Contents

releasing a portion of our valuation allowance to establish deferred tax assets. Operating results in 2005 were also impacted by $6.0 million in revenue from
the sale of inventory to Schering-Plough pursuant to our 2004 license agreement, while 2004 includes $12.5 million in revenue from Schering-Plough agreements. The net loss in 2004 also includes $9.2 million of costs related to our January 2004
restructuring.



Revenues



Revenues consisted of the following:



|                                     |  |                                 |         |      |   |       
|------------------------------------ |  | ------------------------------- | ------- | ---- | - | ------
|                                     |  | For the years endedDecember 31,
|                                     |  | 2005                            |         | 2004
|(in thousands)                       |  |                                 |         |     
|Net product sales                    |  | $                               | 125,853 |      | $ | 8,348 
|License fees and milestones revenues |  |                                 | 6,564   |      |   | 13,070
|Grant and other revenues             |  |                                 |        |      |   | 971   
|                                     |  |                                 |         |      |   |       
|Total revenues                       |  | $                               | 132,417 |      | $ | 22,389
|                                     |  |                                 |         |      |   |       



RevenueVancocin product sales



In 2004,
Vancocin sales commenced in November 2004, upon our acquisition of the product from Lilly. The factors contributing to the level of net sales of Vancocin in the year ended December 31, 2005 include a 34.5% increase in prescriptions, as reported
by a third-party, over the 2004 period and the realization of the sales price increases announced in December 2004, March 2005 and August 2005. Additionally, we believe the 2005 net product sales were affected by wholesaler inventory restocking
to normal levels during the first quarter of 2005, resulting from Lillys product allocation during the third and fourth quarters of 2004.



Net sales of Vancocin were $40.3 million and $125.9 million for the three and twelve-months ended December 31, 2005, respectively, driven by price
increases and prescription demand. Prescriptions increased 39.5% and 34.5% for the three and twelve months ended December 31, 2005, respectively, as compared to the same periods in 2004. Additionally, while fourth quarter 2005 prescriptions
decreased approximately 4.0% from third quarter 2005 prescriptions, net sales of Vancocin in the fourth quarter of 2005 increased 13.1% over the third quarter of 2005. The prescription trend in the fourth quarter of 2005 compares favorably to the
6.3% decrease experienced from the third to fourth quarter of 2004. This increase was due to the following factors: the impact of the price increases announced in August 2005 and an increase in estimated wholesaler inventory to levels that we
believe to be at the higher end of normal, partially offset by the fact that in the fourth quarter of 2005, the unit mix sold between the two presentations of Vancocin favored the lower priced presentation compared to the preceding quarter. We can
not predict future prescription demand with any certainty. In the 2004 periods, net product sales were $8.3 million for the three and twelve months ended December 31, 2004, which are not comparable to the 2005 periods as we acquired Vancocin
from Lilly in November 2004.



During 2004 and a portion of the
quarter ended March 31, 2005, Vancocin was sold under our transition services agreement with Lilly, who was our only customer during the transition period. The transition agreement was terminated in January 2005, and upon the termination, we
began selling directly to wholesalers. Approximately 95% of our sales are to three wholesalers. Vancocin product sales are influenced by prescriptions and wholesaler forecasts of prescription demand, which could be at different levels from period to
period. As of December 31, 2005, we have reviewed net sales under our revenue recognition policy and no deferrals are necessary. This review also resulted in our determination that the estimated inventory held at the end of December 2005 by the
three largest wholesalers, although increased from September 2005, was within a normal range for Vancocin.



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RevenueLicense fee and milestone revenue



License fee and milestone revenue primarily includes the following:



| | · |  | In 2005, the sale of inventory for $6.0 million pursuant to the terms of our license agreement with Schering-Plough for intranasal pleconaril.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | In 2004, payments of $10.0 million pursuant to the terms of our license agreement with Schering-Plough for intranasal pleconaril.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------



| | · |  | In 2004, advanced payments from Schering-Plough of $2.5 million.
| | - |  | ----------------------------------------------------------------



| | · |  | In both 2004 and 2005, amortization of payments received under our agreement with Wyeth of $0.6 million.
| | - |  | --------------------------------------------------------------------------------------------------------



Our license fee and milestone revenues result from existing or future collaborations of development-stage product and
currently vary greatly from period to period. (See Liquidity, Operating Cash Inflows for additional information)



RevenueGrant and other revenue



For 2005, we recognized no grant and other revenue. During 2004, we recognized $0.7 million related to amounts agreed to be paid under our agreement with
Schering-Plough and $0.3 million in grant payments under contracts that were transferred to a third party during 2004.



Cost of sales and gross product margin



|                     |  |                                 |         |      |   |      
|-------------------- |  | ------------------------------- | ------- | ---- | - | -----
|                     |  | For the years endedDecember 31,
|                     |  | 2005                            |         | 2004
|(in thousands)       |  |                                 |         |     
|Net product sales    |  | $                               | 125,853 |      | $ | 8,348
|Cost of sales        |  |                                 | 18,029  |      |   | 1,717
|                     |  |                                 |         |      |   |      
|Gross product margin |  | $                               | 107,824 |      | $ | 6,631
|                     |  |                                 |         |      |   |      



Vancocin cost of sales
includes the cost of materials and distribution costs. Our gross product margin rate (net product sales less cost of sales as a percent of net product sales) for Vancocin increased in 2005 to 85.7% from 79.4% in 2004, which is primarily the result
of our price increases announced in December 2004, March 2005 and August 2005.



Our cost to acquire Vancocin may be higher if we experience the need for increased production volumes above previously estimated amounts. As part of our November 2005 amendment of our manufacturing agreement with
Lilly, we increased the amount of Vancocin that Lilly supplied to us, which resulted in additional costs for finished goods at December 31, 2005 of $4.5 million. This additional cost will increase our cost of sales as these specific units are
sold, which we expect to sell in the first half of 2006.



Lilly
will continue to manufacture finished product for us though September 30, 2006. We also expect our third party supply chain to be operational during 2006. Thus, while we expect our gross product margin to improve during 2006 over 2005, our
actual margins will be impacted by the actual volume of finished product we order from each of Lilly and OSG Norwich. Moreover, to the extent that manufacturing yields increase or decrease after the manufacturing of Vancocin has been transitioned
from Lilly to third parties, we anticipate that the unit cost to manufacture Vancocin may decrease or increase, respectively. As a result, we would expect the cost of product sales of Vancocin, and accordingly, gross product margin percentage, to
fluctuate from quarter to quarter during 2006. Additionally, if we enter into fee-for-service agreements with wholesalers in future periods, the fees would negatively impact our gross product margins.



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Research and development expenses



For each of our research and development programs, we incur both direct and indirect expenses. Direct expenses include third
party costs related to these programs such as contract research, consulting, cost sharing payments or receipts, and preclinical and development costs. Indirect expenses include personnel, facility, and other overhead costs.



Research and development expenses were divided between our research and
development programs in the following manner:



|                         |  |                                 |        |      |   |       
|------------------------ |  | ------------------------------- | ------ | ---- | - | ------
|                         |  | For the years endedDecember 31,
|                         |  | 2005                            |        | 2004
|(in thousands)           |  |                                 |        |     
|DirectCore programs     |  |                                 |        |      |   |       
|CMV                      |  | $                               | 4,817  |      | $ | 3,207 
|HCV                      |  |                                 | 90     |      |   | 1,317 
|Vancocin / C. difficile  |  |                                 | 236    |      |   |      
|DirectNon-core programs |  |                                 |        |      |   |       
|Common cold              |  |                                 | 13     |      |   | 106   
|Indirect                 |  |                                 |        |      |   |       
|Development              |  |                                 | 5,454  |      |   | 8,239 
|Discovery research       |  |                                 |       |      |   | 3,519 
|                         |  |                                 |        |      |   |       
|Total                    |  | $                               | 10,610 |      | $ | 16,388
|                         |  |                                 |        |      |   |       



DirectCore
Programs



Related to our CMV program, during 2005 we were
conducting one phase 2 clinical study involving CMV-seropositive subjects who have undergone allogeneic stem cell transplantation and were collecting or analyzing data from several phase 1 clinical trials with maribavir (to evaluate the potential
for drug interactions, pharmacokinetics in subjects with renal or hepatic impairment, and the evaluation of different tablet formulations). In November 2005, we completed enrollment in our Phase 2 clinical trial. During 2004, we initiated two phase
1 clinical trials with maribavir to evaluate the potential for drug interactions and to evaluate the pharmacokinetics of maribavir in subjects with renal impairment, respectively, and we initiated one phase 2 clinical study involving
CMV-seropositive subjects who have undergone allogeneic stem cell transplantation.



Related to our HCV program, 2005 costs included payments to Wyeth made in accordance with our cost-sharing arrangement. During 2005, we initiated phase 1 clinical trials with our HCV compound, HCV-796. Wyeth pays a
substantial portion of the collaborations predevelopment and development expenses. In addition, during the quarter ended March 31, 2005, we halted development on our former HCV lead product candidate, HCV-086. During 2004, the primary
drivers of these costs were phase 1 clinical trials for HCV-086 and preclinical activities related to HCV-796.



During 2005, we incurred costs totaling $0.2 million for research and development activities related to Vancocin and C. difficile. During 2004, we
had no similar activities.



DirectNon-Core
Programs



In 2005, we incurred minimal direct costs
related to our common cold program. In 2004, all non-core program direct expenses were related to the completion of phase 1 clinical trials with the intranasal formulation of pleconaril, which was our only active product candidate in our non-core
programs. The gross costs of $1.1 million for the year ended December 31, 2004 were netted by a $0.4 million credit from a revision of the



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estimated costs accrued for clinical development related to the oral formulation of pleconaril and a $0.6 million credit resulted from a settlement of a
disputed accounts receivable for shared development expenses for oral formulation of pleconaril. In November 2004, Schering-Plough assumed responsibility for all future development and commercialization of pleconaril.



Indirect Expenses



The decrease in expenses related to indirect development activities was due
primarily to the reduction of headcount and costs that resulted from the January 2004 restructuring.



We had no discovery research costs in 2005 as we exited these activities in our January 2004 restructuring. In 2004, our indirect expenses related to our
discovery research activities also included $1.8 in million costs related to the January 2004 restructuring.



Marketing, general and administrative expenses



Marketing, general and administrative (MG&A) expenses of $10.5 million decreased $5.2 million for the year ended December 31, 2005 compared to
the same period in 2004. The $5.2 million decrease was primarily due to $5.6 million of costs related to the January 2004 restructuring, $1.1 million charge related to the exit of an operating lease in 2004, and $0.6 million of second quarter 2004
costs related to our terminated bond offering. After considering these 2004 expenses, MG&A increased by $2.1 million primarily due to 2005 commercial and other personnel related expenses, partially offset by reduced facility costs.



Intangible amortization and acquisition of technology rights



Intangible amortization is the result of the Vancocin
product rights acquisition in the fourth quarter of 2004. We had a valuation study performed by a third party, based on information provided by management, to determine the allocation of the estimated purchase price of the Vancocin acquisition among
the intangible assets acquired as well as their estimated amortization period.



Intangible amortization was $5.2 million for 2005 and $0.7 million for 2004. The 2005 period includes $0.3 million of cumulative amortization related to $10.5 million contingent consideration. To the extent that we
incur an obligation to Lilly for additional payments on Vancocin sales, as described in our agreement with Lilly, we will account for any future payment to Lilly as a contingent consideration and record an adjustment to the carrying amount of the
related intangible asset and a cumulative adjustment to the intangible amortization upon achievement of the related sales milestones. Contingent consideration and Lilly related additional payments are more fully described under Recent
Events, Vancocin Capsules above and in Note 6 of the Consolidated Financial Statements.



On an ongoing periodic basis, we evaluate the useful life of these intangible assets and determine if any economic, governmental or regulatory event has
impaired the value of the assets or modified their estimated useful lives. As of December 31, 2005, there was no impairment of the carrying value of the intangible assets or change to the useful lives as estimated at the acquisition date.



Other Income (Expense)



Change in fair value of derivative liability



Based upon relevant information available, we estimated the fair value of
the make-whole provision contained within our senior notes using a Monte Carlo simulation model to be $8.6 million, which included $7.9 million at the time of conversion of the senior notes into senior convertible notes in January 2005 and $0.7
million upon exercise of the initial investors purchase option in April 2005. This fair value of the make-whole



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provision, which was recorded as a derivative liability, was adjusted quarterly for changes in fair value during the periods that the senior convertible
notes were outstanding, with the corresponding charge or credit to change in fair value of derivative liability. These adjustments resulted in a loss on the change in fair value of derivative liability of $4.0 million for the year ended
December 31, 2005. Since all the senior convertible notes were converted in July 2005, no derivative liability remains.



Net gain on bond repurchase



We recorded a $1.1 million net gain on the bond repurchase related to the repurchase of $49.0 million of subordinated convertible notes in 2005 for $47.6
million. The net gain is comprised of an aggregated gross gain of $1.4 million, less the write-off of $0.3 million of deferred finance costs.



Gain on sale of biodefense assets, net



During the third quarter of 2004, we sold certain of our non-core assets, including compounds, assays and other intellectual property related to the
development of antiviral drugs targeting the smallpox virus and viral hemorrhagic fever viruses, which resulted in a net gain on sale of $1.7 million.



Interest Income



Interest income for years ended December 31, 2005 and 2004 was $2.0 million and $1.1 million, respectively. Interest income increased primarily due
to investments of the cash received from the issuance of common stock in December 2005. Prior to that increase in cash, interest income had not fluctuated materially as interest rate increases had offset our then lower invested balances.



Interest Expense



|                                                     |  |                                 |        |      |   |       
|---------------------------------------------------- |  | ------------------------------- | ------ | ---- | - | ------
|                                                     |  | For the years endedDecember 31,
|                                                     |  | 2005                            |        | 2004
|(in thousands)                                       |  |                                 |        |     
|Interest expense on 6% subordinated converible notes |  | $                               | 6,150  |      | $ | 7,657 
|Interest expense on 10% senior notes                 |  |                                 | 330    |      |   | 1,267 
|Interest expense on 6% senior convertible notes      |  |                                 | 1,635  |      |   |      
|Amortization of finance costs                        |  |                                 | 981    |      |   | 1,369 
|Amortization of debt discount                        |  |                                 | 697    |      |   |      
|Beneficial conversion feature                        |  |                                 | 1,489  |      |   |      
|Other interest                                       |  |                                 | 22     |      |   | 27    
|                                                     |  |                                 |        |      |   |       
|Total interest expense                               |  | $                               | 11,304 |      | $ | 10,320
|                                                     |  |                                 |        |      |   |       



Interest expense on
notes includes interest on all our notes outstanding and decreased over 2004 due to varying principal amounts outstanding during the periods. Amortization of finance costs and debt discount in 2005 relates primarily to the senior convertible notes
issued in January and April 2005, which were fully converted to common stock during the year, and in 2004 relates primarily to the senior notes issued in October 2004. The beneficial conversion feature related to the automatic conversions of the
senior convertible notes in June and July 2005 and is the result of the fair value of the shares of common stock on the commitment date exceeding the stock value as defined by the auto-conversion provisions. See Note 8 of the Consolidated Financial
Statements regarding the automatic conversion.



On
March 1, 2006, the Company redeemed the remaining $78.9 million principal amount of subordinated convertible notes for $79.6 million. This eliminated the Companys long-term debt that was outstanding at December 31, 2005. We will take
a charge of $1.2 million related to this payment in the first quarter of 2006, which represents a loss of $0.7 million and the write-off of deferred finance costs of $0.5 million.



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Income Tax Benefit



Our effective income tax benefit rate was 49.8% for the year ended December 31, 2005. Our income tax benefit of $37.8
million for the year ended December 31, 2005 includes $47.8 million to record our deferred tax assets by reducing our valuation allowance. This was necessary as we believe we will utilize a portion of the net operating loss and credit
carryforwards, among other things. Additionally, we recorded income tax expense of $10.0 million, based on a combined federal and state estimated annual effective tax rate of 13.2%. The estimated annual effective tax rate was based on our estimated
taxable income for 2005, which includes, among other things, the utilization of a portion of our available net operating loss and credit carryforwards.



Since we established our net deferred tax assets in 2005, we recorded a $47.8 million income tax benefit, as described above. We currently do not
anticipate income tax benefits of this magnitude in the foreseeable future. We expect that future periods will include taxes at a higher rate than the effective rate for 2005. Due to the recognition of the deferred tax assets in 2005, we expect an
effective income tax rate of 38% in 2006.



We will continue to
evaluate the realizability of our deferred tax assets and liabilities on a periodic basis, and will adjust such amounts in light of changing facts and circumstances, including but not limited to future projections of taxable income, tax legislation,
rulings by relevant tax authorities and the progress of ongoing tax audits. Should we further reduce the valuation allowance of deferred tax assets in future years, a tax benefit would be recognized. For further discussion see Critical
Accounting Policies and Note 12 of the Consolidated Financial Statements regarding income taxes.



Years ended December 31, 2004 and 2003



Overview



|                      |  |                                 |         |   |      |   |         |  
|--------------------- |  | ------------------------------- | ------- | - | ---- | - | ------- | -
|                      |  | For the years endedDecember 31, |        
|                      |  | 2004                            |         |   | 2003 |  
|(in thousands)        |  |                                 |         |   |      |  
|Net product sales     |  | $                               | 8,348   |   |      | $ |        |  
|Total revenues        |  | $                               | 22,389  |   |      | $ | 1,612   |  
|Net (loss)            |  | $                               | (19,534 | ) |      | $ | (36,942 | )
|                      |  |                                
|Net (loss) per share: |  |                                 |         |   |      |   |         |  
|Basic and Diluted     |  | $                               | (0.73   | ) |      | $ | (1.43   | )



For the year ended
December 31, 2004, we recorded revenues of $22.4 million as a result of commencing sales of Vancocin in November 2004 and payments from our agreement with Schering-Plough related to intranasal pleconaril.



The 2004 net loss includes $9.2 million of costs incurred as the result of
the January 2004 restructuring. The decrease in net loss of $17.4 million from the year ended December 31, 2003 to the same period in 2004 was due primarily to $8.3 million of net sales of Vancocin which commenced in November 2004, $12.5
million in revenue recognized in the year ended December 31, 2004 from the Schering-Plough agreements, reduction in headcount and operational costs resulting from our restructuring during January 2004, and a $1.7 million gain on the sale of
non-core assets in the year ended December 31, 2004. The net loss in 2003 included the write-off of $3.5 million for the acquired technology rights for maribavir which was offset by a $3.6 million gain, after the write-off of related debt issue
costs, from our reduction of $7.0 million in principal amount of our outstanding subordinated convertible notes.



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Revenues



Revenues consisted of the following:



|                                     |  |                               |        |      |   |      
|------------------------------------ |  | ----------------------------- | ------ | ---- | - | -----
|                                     |  | For the year endedDecember 31
|                                     |  | 2004                          |        | 2003
|(in thousands)                       |  |                               |        |     
|Net product sales                    |  | $                             | 8,348  |      | $ |     
|License fees and milestones revenues |  |                               | 13,070 |      |   | 1,084
|Grant and other revenues             |  |                               | 971    |      |   | 528  
|                                     |  |                               |        |      |   |      
|Total revenues                       |  | $                             | 22,389 |      | $ | 1,612
|                                     |  |                               |        |      |   |      



RevenueVancocin product sales



For the
year ended December 31, 2004, we recognized net sales of Vancocin of approximately $8.3 million, which represents net sales from November 9, 2004 when we acquired the rights to Vancocin from Lilly. During this time period, Vancocin was
sold under our transition services agreement to Lilly, who was our only customer. Following the termination of our transition agreement, which occurred in January 2005, we are selling directly to wholesalers.



RevenueLicense fee and milestone revenue



License fee and milestone revenue primarily includes the following:



| | · |  | In 2004, payments of $10 million pursuant to the terms of our license agreement with Schering-Plough for intranasal pleconaril.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------



| | · |  | Advanced payments from Schering-Plough of $2.5 million in 2004 and $0.5 million in 2003.
| | - |  | ----------------------------------------------------------------------------------------



| | · |  | In both the 2004 and 2003 periods, amortization of payments received under our agreement with Wyeth was $0.6 million.
| | - |  | ---------------------------------------------------------------------------------------------------------------------



RevenueGrant and other revenue



For the year ended December 31, 2004, we recognized grant and other
revenue of approximately $1.0 million, which increased by $0.5 million from the $0.5 million we recognized for the same period in 2003. During 2004, we received $0.7 million for amounts agreed to be paid under our agreement with Schering-Plough that
had no comparable payments in 2003 and received $0.2 million less in grant payments in 2004 as compared to 2003 as the result of our January 2004 restructuring.



Cost of sales and gross product margin



|                     |  |                                 |       |      |   |  
|-------------------- |  | ------------------------------- | ----- | ---- | - | -
|                     |  | For the years endedDecember 31,
|                     |  | 2004                            |       | 2003
|(in thousands)       |  |                                 |       |     
|Net product sales    |  | $                               | 8,348 |      | $ | 
|Cost of sales        |  |                                 | 1,717 |      |   | 
|                     |  |                                 |       |      |   |  
|Gross product margin |  | $                               | 6,631 |      | $ | 
|                     |  |                                 |       |      |   |  



Vancocin cost of sales
includes the cost of materials and distribution costs. We had no cost of sales in the 2003 periods as we acquired Vancocin in November 2004. Our gross product margin (net product sales less cost of sales as a percent of net product sales) for
Vancocin during 2004 was 79.4%.



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##### Table of Contents

Research and development expenses



For each of our research and development programs, we incur both direct and indirect expenses. Direct expenses include third
party costs related to these programs such as contract research, consulting, cost sharing payments or receipts, and preclinical and development costs. Indirect expenses include personnel, facility, and other overhead costs.



Research and development expenses decreased approximately $6.6 million to
$16.4 million in the year ended December 31, 2004 from $23.0 million in the year ended December 31, 2003 as a result of our reduction in headcount and operational costs resulting from our restructuring announced in January 2004. Our
research and development expenses were divided between our research and development programs in the following manner:



|                         |  |                                 |        |      |   |       
|------------------------ |  | ------------------------------- | ------ | ---- | - | ------
|                         |  | For the years endedDecember 31,
|                         |  | 2004                            |        | 2003
|(in thousands)           |  |                                 |        |     
|DirectCore programs     |  |                                 |        |      |   |       
|CMV                      |  | $                               | 3,207  |      | $ | 100   
|HCV                      |  |                                 | 1,317  |      |   | 14    
|DirectNon-core programs |  |                                 |        |      |   |       
|Common cold              |  |                                 | 106    |      |   | 801   
|CEMA                     |  |                                 |       |      |   | 944   
|Indirect                 |  |                                 |        |      |   |       
|Development              |  |                                 | 8,239  |      |   | 10,291
|Discovery research       |  |                                 | 3,519  |      |   | 10,893
|                         |  |                                 |        |      |   |       
|Total                    |  | $                               | 16,388 |      | $ | 23,043
|                         |  |                                 |        |      |   |       



DirectCore
Programs



In the year ended December 31, 2004, we
incurred $3.2 million in direct expenses related to our CMV program. During the year ended December 31, 2004, we initiated two phase 1 clinical trials with maribavir to evaluate the potential for drug interactions and to evaluate the
pharmacokinetics of maribavir in subjects with renal impairment, respectively, and we initiated one phase 2 clinical study involving CMV-seropositive subjects who have undergone allogeneic stem cell transplantation. We had no material expenses under
this program in the year ended December 31, 2003, as we did not acquire the rights for its development and commercialization until August 2003.



During the year ended December 31, 2004, we incurred $1.3 million of direct costs related to development activities of our HCV program, which
increased $1.3 million from the year ended December 31, 2003. These costs are net of payments from Wyeth made in accordance with our cost-sharing arrangement. During 2004, the primary drivers of these costs were phase 1 clinical trials for
HCV-086. During the year ended December 31, 2003, the primary drivers of $0.7 million in costs were phase 1 clinical trials for a previous lead product candidate and predevelopment activities on backup compounds, and were nearly offset by a
$0.7 million credit related to the 2003 amendment of our agreement with Wyeth.



DirectNon-Core Programs



In the year ended December 31, 2004, we incurred $0.1 million in direct costs related to our common cold program compared to $0.8 million in direct costs during the year ended December 31, 2003. In the year ended December 31,
2004, all non-core program direct expenses were related to the intranasal formulation of pleconaril, our only active product candidate in our non-core programs. The gross costs of $1.1 million for the year ended December 31, 2004 were netted by
a $0.4 million credit from a revision of the estimated costs



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##### Table of Contents

accrued for clinical development related to the oral formulation of pleconaril and a $0.6 million credit resulted from a settlement of a disputed accounts
receivable for shared development expenses for oral formulation of pleconaril. During the year ended December 31, 2003, we incurred $0.9 million of direct expenses related to clinical and regulatory activities related to our efforts to pursue
the development of pleconaril for the treatment of serious and life-threatening diseases caused by enteroviral infections (CEMA). We ceased these development activities in connection with our January 2004 restructuring and have no comparable 2004
direct costs.



Indirect Expenses



In the year ended December 31, 2004, we incurred $8.2 million of
indirect expenses related to our development activities, which decreased $2.1 million from $10.3 million in the year ended December 31, 2003. The decrease of $2.1 million was due primarily to the reduced headcount resulting from the January
2004 restructuring. Included in the costs recorded in 2004 are $1.8 million in severance and transition costs from our January 2004 restructuring.



In the year ended December 31, 2004, we incurred $3.5 million of indirect expenses related to our discovery research activities, which decreased from
$10.9 million in the same period of 2003. We exited our discovery research activities in January 2004. Included in the 2004 indirect costs is a $1.8 million charge for severance and related costs of the January 2004 restructuring.



Marketing, general and administrative expenses



Marketing, general and administrative expenses for the year ended
December 31, 2004 of approximately $15.6 million increased $6.6 million from $9.0 million for the year ended December 31, 2003. Included in the expenses for the period in 2004 is $5.6 million in severance and stock option modification
costs and asset impairment costs that were the result of the January 2004 restructuring, $1.1 million for a charge related to the exit of an operating lease, $0.6 million in costs related to our terminated bond restructuring, an increase in expenses
of $0.9 million related to business development efforts undertaken during 2004, $0.5 million in costs related to the Schering-Plough license agreement and $0.6 million in increased accounting, public company and other expenses. Included in the
expenses for the year ended December 31, 2003 is a $1.7 million charge for lease commitments.



Intangible amortization and acquisition of technology rights



Intangible amortization was $0.7 million for the year ended December 31, 2004. Intangible amortization is the result of
the Vancocin product rights acquisition in the fourth quarter of 2004. We had a valuation study performed by a third party, based on information provided by management, to determine the allocation of the estimated purchase price of the Vancocin
acquisition among the intangible assets acquired as well as their estimated amortization period.



In September 2003, we paid GSK a $3.5 million license fee in connection with our agreement for the worldwide rights (excluding Japan) to maribavir, or
VP41263, an inhibitor of CMV. This fee was recognized as an acquisition of technology rights and was expensed during 2003.



Interest and other expenses (gains)



Interest income for the year ended December 31, 2004 of $1.1 million decreased $0.7 million from interest income of $1.8 million for the year ended
December 31, 2003. This was due to lower invested balances. Interest expense for the year ended December 31, 2004 of $10.3 million increased $1.9 million compared to $8.4 million in interest expense from the year ended December 31,
2003 due to the interest and amortization of financing costs from the issuance of the senior notes in October 2004.



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Liquidity



We expect that our near term sources of revenue will arise from Vancocin product sales and milestone and license fee payments that we may receive from
Wyeth and Schering-Plough if agreed upon events under our agreements with each of these companies are achieved. However, we cannot predict what the actual sales of Vancocin will be in the future, and there are no assurances that the events that
require payments to us under the Wyeth and Schering-Plough arrangements will be achieved. In addition, while demand for Vancocin exceeded our estimates in 2005, there are no assurances that such demand will continue.



Our ability to generate positive cash flow is also impacted by the timing of
anticipated events in our CMV and HCV programs, including results from clinical trials, the results of our product development efforts, and variations from our estimate of future direct and indirect expenses.



While we anticipate that revenues from Vancocin will continue to generate
positive cash flow and should allow us to fund substantially all of our ongoing development and other operating costs, we may need additional financing in order to expand our product portfolio. At December 31, 2005, we had cash, cash
equivalents and short-term investments of $233.4 million, $79.6 million of which was used in March 2006 to redeem the remaining $78.9 million of long-term debt that was outstanding at December 31, 2005. At December 31, 2005, the annualized
weighted average nominal interest rate on our short-term investments was 2.6%.



During 2004, we funded the $116.0 million purchase price for the Vancocin acquisition through the use of $53.5 million from our cash reserves and the proceeds from the issuance of $62.5 million aggregate principal
amount of senior notes and warrants to purchase 5.0 million shares of our common stock. The senior notes and the warrants were automatically exchanged for 6% senior convertible notes following stockholder approval of the issuance of the senior
convertible notes on January 19, 2005. In April 2005, the initial investors in the senior notes exercised their purchase option and acquired an additional $12.5 million of the senior convertible notes with identical terms. By September 30,
2005, the entire principal balance of the senior convertible notes was converted into common stock. For more information regarding the senior convertible notes, see Note 8 of the Consolidated Financial Statements.



Overall Cash Flows



During the year ended December 31, 2005, we generated $71.5 million of
net cash from operating activities, primarily from the cash contribution of Vancocin, our first commercial product, which includes the effects of net income and building inventory and $6.0 million from the sale of inventory to Schering-Plough,
offset by $6.8 million in cash payments related to the make-whole provisions on the senior convertible notes. We also received $8.6 million from investing activities, which is the net result of the release of $9.0 million of restricted investments,
the $10.5 million paid to Lilly for contingent consideration, and the decrease in cash held in short term investments. Our net cash provided by financing activities for the year ended December 31, 2005 was $129.1 million. This is primarily the
net result of $163.5 million of net proceeds from the issuance of common stock completed in December 2005, the $11.7 million of net proceeds from the issuance of senior convertible notes and the use of $47.6 million for the repurchase of
subordinated convertible notes.



Operating Cash Inflows



We began to receive cash inflows from the sale of
Vancocin in January 2005. We cannot reasonably estimate the period in which we will begin to receive material net cash inflows from our product candidates currently under development. Cash inflows from development-stage products are dependent on
several factors, including the achievement of milestones and regulatory approvals. We may not receive milestone payments from any existing or future collaborations if a development-stage product fails to meet technical or performance targets or
fails to obtain the required regulatory approvals. Further, our revenues from collaborations will be affected by efforts of our collaborative partners. Even if we achieve technical success in developing drug



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candidates, our collaborative partners may not devote the resources necessary to complete development and commence marketing of these products, when and if
approved, or they may not successfully market these products.



Operating
Cash Outflows



The cash flows we have used in
operations historically have been applied to research and development activities, marketing and business development efforts, general and administrative expenses, and servicing our debt. Future cash flows will also include income tax payments.
Bringing drugs from the preclinical research and development stage through phase 1, phase 2, and phase 3 clinical trials and FDA approval is a time consuming and expensive process. Because our product candidates are currently in the clinical stage
of development, there are a variety of events that could occur during the development process that will dictate the course we must take with our drug development efforts and the cost of these efforts. As a result, we cannot reasonably estimate the
costs that we will incur through the commercialization of any product candidate. The most significant uses of our near-term operating development cash outflows are as described below.



For each of our development programs, we incur both direct and indirect expenses. Direct expenses include third party costs
related to these programs such as contract research, consulting, cost sharing payments or receipts, and preclinical and clinical development costs. Indirect expenses include personnel, facility and other overhead costs.



Direct expensesCore Development Programs



CMV programFrom the date we in-licensed maribavir through
December 31, 2005, we incurred $11.6 million of direct costs in connection with this program, including the acquisition fee of $3.5 million paid to GSK for the rights to maribavir in September 2003.



During 2006, we expect maribavir-related activities to include completion of
the phase 2 study that we initiated during July 2004, as well as the continuation of a series of phase 1 clinical pharmacology studies to support the clinical development program. Depending on the outcome of the phase 2 study, additional clinical
development activities may be pursued. The results of this phase 2 study will significantly impact the timing and the amount of expenses, including potential milestone payments to GSK, that we will incur related to this program in future periods.
However, if our CMV program progresses into phase 3 clinical development in 2006, we expect our expenses in 2006 for this program to be substantially higher than in 2005. In addition, discussions with the FDA regarding these future studies may
impact the timing, nature and cost of future planned studies. We are solely responsible for the cost of developing our CMV product candidate.



Should we achieve certain product development events, we are obligated to make certain milestone payments to GSK, the licensor of maribavir.



HCV programFrom the date that we commenced predevelopment
activities for compounds in this program that are currently active through December 31, 2005, we incurred $2.0 million in direct expenses for the predevelopment and development activities relating to such compounds. These costs are net of
contractual cost sharing arrangements between Wyeth and us. Wyeth pays a substantial portion of the collaborations predevelopment and development expenses.



During 2006, the planned activities include phase 1 testing of our HCV product candidate, HCV-796, in combination with
pegylated interferon. If these data are supportive, we and Wyeth anticipate initiation of one or more phase 2 studies in 2006. The results of the planned studies, along with other predevelopment activities performed during the year, will
significantly impact the timing and amount of expenses we will incur related to this program in future periods. In addition, discussions with the FDA regarding these future studies may impact the timing, nature and cost of future planned studies.



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Should we achieve certain product development events, Wyeth is required to pay us certain cash milestones
and to purchase, in cash, our common stock pursuant to terms of our collaboration agreement. Based on the activities planned by Wyeth and us, there is the potential to achieve one of these milestones in 2006. However, there can be no assurances that
we will be successful in achieving this milestone during this timeframe, or at all.



Vancocin and C. difficile relatedWe acquired Vancocin in November 2004 and have spent approximately $0.2 million in direct research and development costs related to Vancocin or on related C.
difficile activities since acquisition.



During 2006, we
expect our research and development activities in the field of C. difficile to increase significantly and we expect this increase to result in additional direct costs above 2005 levels.



Direct ExpensesNon-Core Development Programs



Common ColdFrom the date that we commenced predevelopment
activities for the intranasal formulation of pleconaril through December 31, 2005, we incurred $1.9 million in direct expenses. We did not incur any significant direct expenses in connection with this program in 2005, nor will we in the future,
as Schering-Plough has assumed responsibility for all future development and commercialization of pleconaril.



In November 2004, we entered into a license agreement with Schering-Plough under which Schering-Plough has assumed responsibility for all future
development and commercialization of pleconaril. Schering-Plough paid us an initial license fee of $10.0 million in December 2004 and purchased our existing inventory of bulk drug substance for an additional $6.0 million in January 2005. We will
also be eligible to receive up to an additional $65.0 million in milestone payments upon achievement of certain targeted regulatory and commercial events, as well as royalties on Schering-Ploughs sales of intranasal pleconaril in the licensed
territories.



Business development activities



Through December 31, 2005, we paid an acquisition
price of $116.0 million, paid $10.5 million related to additional purchase price consideration tied to product sales (see Recent Events, Vancocin Capsules above and Note 6 of the Consolidated Financial Statements) and
incurred $2.0 million of fees and expenses in connection with the Vancocin acquisition. We also paid an acquisition fee of $3.5 million paid to GSK in 2003 for the rights to maribavir.



In addition, we intend to seek to acquire additional products or product candidates. The costs associated with acquiring any
additional product or product candidate can vary substantially based upon market size of the product, the commercial effort required for the product, the products current stage of development, and actual and potential generic and non-generic
competition for the product, among other factors. Due to the variability of the cost of acquiring a product candidate, it is not feasible to predict what our actual acquisition costs would be, if any, however, the costs could be substantial.



Debt service requirements



Subordinated Convertible Notes



On March 1, 2006, we redeemed the remaining $78.9 million principal
amount of subordinated convertible notes for $79.6 million. This eliminated all long-term debt that was outstanding at December 31, 2005. See Note 8 of the Consolidated Financial Statements for additional information regarding our subordinated
convertible notes.



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Contractual Obligations



Future contractual obligations and commercial commitments at December 31, 2005 are as follows:



|                                      |  |       |        |               |   |           |  |           |       |                 |   |       |  |   |      
|------------------------------------- |  | ----- | ------ | ------------- | - | --------- |  | --------- | ----- | --------------- | - | ----- |  | - | -----
|Contractual Obligations (1)           |  | Total |        | 1 yearor less |   | 2-3 years |  | 4-5 years |       | Morethan5 years
|(in thousands)                        |  |       |        |               |   |           |  |           |       |                
|Current portion of long-term debt (2) |  | $     | 78,920 |               | $ | 78,920    |  | $         |      |                 | $ |      |  | $ |     
|Minimum purchase requirements (3)     |  |       | 3,351  |               |   | 3,351     |  |           |      |                 |   |      |  |   |     
|Operating leases (4)                  |  |       | 8,217  |               |   | 671       |  |           | 1,336 |                 |   | 1,332 |  |   | 4,878
|                                      |  |       |        |               |   |           |  |           |       |                 |   |       |  |   |      
|Total                                 |  | $     | 90,488 |               | $ | 82,942    |  | $         | 1,336 |                 | $ | 1,332 |  | $ | 4,878
|                                      |  |       |        |               |   |           |  |           |       |                 |   |       |  |   |      

---

|(1) |  | This table does not include any milestone payments under our agreement with GSK in relation to our in-licensed technology, as the timing and likelihood of such payments are not
known. Similarly, it does not include any additional payments due to Lilly in connection with the Vancocin acquisition, as the amount and timing of future additional payments are not determinable. Under the terms of the agreement with Lilly, Lilly
is entitled to additional payments on net sales of Vancocin through 2011. The additional payments to be paid to Lilly are calculated as follows:
|--- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|                  |  |                                                
|----------------- |  | -----------------------------------------------
|2006              |  | 35% payment on net sales between $46-65 million
|2007              |  | 35% payment on net sales between $48-65 million
|2008 through 2011 |  | 35% payment on net sales between $45-65 million



No additional payments
are due to Lilly on sales of Vancocin below or above the sales levels reflected in the above table. We will account for the future payments as contingent consideration and will record an adjustment to the carrying amount of the related intangible
asset and a cumulative adjustment to the intangible amortization upon achievement of the related sales milestones. Assuming the maximum threshold is met at the end of each year, the cumulative amortization adjustment would be $0.6 million, $0.7
million and $1.2 million in the years ended December 31, 2006, 2007 and 2008, respectively.



In the event we develop any product line extensions, revive discontinued vancomycin product lines (injectable or oral solution), make improvements of
existing products, or expand the label to cover new indications, Lilly would receive an additional royalty on net sales on these additional products for a predetermined time period.



|(2) |  | Represents principal balance of $78.9 million as of December 31, 2005 for the subordinated convertible notes. These notes were redeemed on March 1, 2006 for $79.6 million
and are no longer outstanding. See Note 8 of the Consolidated Financial Statements.
|--- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) |  | Represents contractual commitment at December 31, 2005. As part of our manufacturing agreement with Lilly, as amended, we have certain minimum purchase requirements of Vancocin
for a period of time less than one year, on a rolling basis. We are not contractually obligated to any amount of purchases past this time period, and cannot reasonably estimate the amount for which we may be obligated in the future. Excludes amounts
related to our November 2005 amendment to our manufacturing agreement with Lilly as these amounts are reported in accounts payable and accrued expenses and other liabilities. See Note 4 of the Consolidated Financial Statements for additional
information.
|--- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



This table does not include
various agreements that we have entered into for services with third party vendors, including agreements to conduct clinical trials, to manufacture product candidates, and for consulting and other contracted services due to the cancelable nature of
the services. We accrue the costs of these agreements based on estimates of work completed to date. We estimate that approximately $3.7 million will be payable in future periods under arrangements in place at December 31, 2005. Of this amount,
approximately $0.8 million has been accrued for work estimated to have been completed as of December 31, 2005 and approximately $2.9 million relates to future performance under these arrangements.



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|(4) |  | We currently lease 33,000 square feet in a facility located in Exton, Pennsylvania for our marketing, development and corporate activities under an operating lease expiring in 2017
with $8.1 million in future rental obligations.
|--- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | Operating leases also includes equipment leases of $0.1 million.
| |  | ----------------------------------------------------------------



Capital Resources



While we anticipate that revenues from Vancocin will continue to generate positive cash flow and should allow us to fund substantially all of our ongoing
development and other operating costs, we may need additional financing in order to expand our product portfolio. Should we need financing, we would seek to access the public or private equity or debt markets, enter into additional arrangements with
corporate collaborators to whom we may issue equity or debt securities or enter into other alternative financing arrangements that may become available to us.



Financing



We have an effective Form S-3 universal shelf registration statement filed with the Securities and Exchange Commission for the potential additional
issuance of up to approximately $39 million of our securities. The registration statement provides us with the flexibility to determine the type of security we choose to sell, including common stock, preferred stock, warrants and debt securities, as
well as the ability to time such sales when market conditions are favorable.



If we raise additional capital by issuing equity securities, the terms and prices for these financings may be much more favorable to the new investors than the terms obtained by our existing stockholders. These
financings also may significantly dilute the ownership of existing stockholders.



Additionally, Wyeth is required to purchase our common stock at the time of successful completion of certain product development events pursuant to the terms of our collaboration agreement. However, in the event we
are not able to successfully achieve the product development events, this additional financing would not be available to us.



If we raise additional capital by accessing debt markets, the terms and pricing for these financings may be much more favorable to the new lenders than
the terms obtained from our prior lenders. These financings also may require liens on certain of our assets that may limit our flexibility.



Additional equity or debt financing, however, may not be available on acceptable terms from any source as a result of, among other factors, our operating
results, our inability to achieve regulatory approval of any of our product candidates, our inability to generate revenue through our existing collaborative agreements, and our inability to file, prosecute, defend and enforce patent claims and or
other intellectual property rights. If sufficient additional financing is not available, we may need to delay, reduce or eliminate current development programs, or reduce or eliminate other aspects of our business.



Critical Accounting Policies



Our consolidated financial statements and accompanying notes are prepared in
accordance with accounting principles generally accepted in the United States of America. Preparing consolidated financial statements requires us to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenues and
expenses and contingent assets and liabilities. Actual results could differ from such estimates. These estimates and assumptions are affected by the application of our accounting policies. Critical policies and practices are both most important to
the portrayal of a companys financial condition and results of operations, and require managements most difficult, subjective or complex judgments, often as a result of the need to make estimates about the effects of matters that are
inherently uncertain.



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Our summary of significant accounting policies is described in Note 2 to our Consolidated Financial
Statements included in Item 8 of this Form 10-K. However, we consider the following policies and estimates to be the most critical in understanding the more complex judgments that are involved in preparing our consolidated financial statements
and that could impact our results of operations, financial position, and cash flows:



| | · |  | Product SalesProduct revenue is recorded upon delivery to the wholesaler, when title has passed. Product demand from wholesalers during a given period may not correlate with
prescription demand for the product in that period. As a result, we periodically estimate and evaluate the wholesalers inventory position. If we believe these levels are too high based on prescription demand and that there may be excess
channel inventory for our product, we may not process wholesaler orders until these levels are reduced. After analysis of our estimated channel inventory, we may defer recognition of revenue on product that has been delivered. From acquisition in
November 2004 through December 31, 2005, we have not deferred any product sales.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



We establish provisions for sales discounts, chargebacks, product returns and rebates. These provisions are primarily based upon the history of Vancocin,
including both Lilly and our ownership periods. We currently have no contracts with private third party payors, such as HMOs. We do have contractual arrangements with governmental agencies, including Medicaid. We establish provisions for
chargebacks and rebates related to these contracts based upon historical experience of government agencies market share and governmental contractual prices. Product return accruals are estimated based on Vancocins history of damage and
product expiration returns. Since actual experience could vary significantly from expectations, we periodically analyze estimated channel inventory, historical governmental usage, potential expiration of unused product and quality assurance
indicators to confirm our monthly provisions appear reasonable and within an acceptable range. Although from acquisition to date, we have not had a material adjustment to our sales related accruals, changes in usage of Vancocin could result in
material impacts on future periods.



| | · |  | Impairment of Long-lived AssetsWe review our fixed and intangible assets for possible impairment whenever events occur or circumstances indicate that the carrying amount of an
asset may not be recoverable. Assumptions and estimates used in the evaluation of impairment may affect the carrying value of long-lived assets, which could result in impairment charges in future periods. Such assumptions include projections of
future cash flows in determining whether an impairment exists and in measuring the current fair value of the asset. These assumptions are subjective and could result in a material impact on operating results in the period of impairment. The Company
has not recognized any impairment during the year ended December 31, 2005.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



On an ongoing periodic basis, we evaluate the useful life of intangible assets and determine if any economic, governmental or regulatory event has impaired the value of the assets or modified their estimated useful
lives. This evaluation has not resulted in a change to the useful life of our intangible assets during the year ended December 31, 2005.



We review our short-term investments on a periodic basis for other-than-temporary impairments. This review is subjective as it requires management to
evaluate whether an event or change in circumstances has occurred in that period that may have a significant adverse effect on the fair value of the investment. As of December 31, 2005, we have deemed our unrealized loss not to be
other-than-temporary. (See Note 3 of the Consolidated Financial Statements)



| | · |  | Stock Based Employee CompensationWe apply APB Opinion No. 25, Accounting for Stock Issued to Employees and related interpretations (APB 25)
in accounting for all stock-based employee compensation. We have elected to adopt only the disclosure provisions of Statement of Financial Accounting Standards No. 123, Accounting for Stock-Based Compensation, as amended (SFAS 123).
Had we applied SFAS 123, the pro forma impact on our net income (loss) for the years ended December 31, 2005, 2004 and 2003 would have been additional expense of $1.4 million, $2.6 million and $7.6 million, respectively. The calculation of this
expense includes judgment related to the period of time used in calculating the volatility of our common stock and our estimate of the exercising habits of
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | our employees, which is also influenced by our Insider Trading Policy. Changes in the volatility of our common stock or the habits of our employees could
result in future expenses that are not consistent with current expenses. See Recently Issued Accounting Pronouncements for discussion on January 1, 2006 adoption of SFAS No. 123R, Share-Based Payments.
| | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | Income TaxesOur annual effective tax rate is based on expected pre-tax earnings, existing statutory tax rates, limitations on the use of tax credits and net operating loss
carryforwards and tax planning opportunities available in the jurisdictions in which we operate. Significant judgment is required in determining our annual effective tax rate and in evaluating our tax position.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



On a periodic basis, we evaluate the realizability of our deferred tax
assets and liabilities and will adjust such amounts in light of changing facts and circumstances, including but not limited to future projections of taxable income, tax legislation, rulings by relevant tax authorities, tax planning strategies and
the progress of ongoing tax audits. Settlement of filing positions that may be challenged by tax authorities could impact the income tax position in the year of resolution. Our current tax liability is presented in the consolidated balance sheet
within income taxes payable.



At December 31, 2005, we
had $98.8 million of gross deferred tax assets, which included the effects of federal and state net operating loss (NOL) carryforwards of $50.6 million, capitalized research and development costs of $37.0 million and other items of $11.2
million. These assets are offset by a $49.1 million valuation allowance as our ability to estimate long-term future taxable income with a high level of certainty is limited. In assessing the realizability of deferred tax assets, we consider whether
it is more likely than not that some portion or all of the deferred tax assets will not be realized. The ultimate realization of deferred tax assets is dependent upon the generation of future taxable income during the period in which those temporary
differences becomes deductible or the NOLs and credit carryforwards can be utilized. When considering the reversal of the valuation allowance, we consider the level of past and future taxable income, the utilization of the carryforwards and other
factors. Based upon these considerations, we reduced our valuation allowance by $47.8 million in the fourth quarter of 2005 as management believes it is more likely than not that we will realize the benefits of a portion of these deferred tax
assets, net of the existing valuation allowances at December 31, 2005. This valuation adjustment reduced our 2005 effective tax rate. We expect that future periods will include income taxes at a higher rate. Revisions to the estimated net
realizable value of the deferred tax asset could cause our provision for income taxes to vary significantly from period to period. Should we further reduce the valuation allowance of deferred tax assets, a current year tax benefit will be recognized
and future periods would then include income taxes at a higher rate than the effective rate in the period that the adjustment is made.



As our business evolves, we may face additional issues that will require increased levels of management estimation and complex judgments.



Recently Issued Accounting Pronouncements



In December 2004, the FASB issued SFAS No. 123R, Share-Based
Payment,(SFAS 123R). This statement replaces SFAS 123 and supersedes APB 25. This statement establishes standards for the accounting for which an entity exchanges its equity instruments for goods or services. This statement also addresses
transactions in which an entity incurs liabilities in exchange for goods or services that are based on the fair value of the entitys equity instruments or that may be settled by the issuance of those equity instruments. SFAS 123R will require
us to measure the cost of employee services received in exchange for an award of equity instruments based on the grant-date fair value of the award. That cost shall be recognized over the period during which an employee is required to provide
service in exchange for the awardthe requisite service period (vesting period). The grant-date fair value of employee share options will be estimated using option-pricing models adjusted for the unique characteristics of those instruments. We
must adopt SFAS 123R in the first quarter of 2006. We are currently evaluating various implementation standards of SFAS 123R, including adoption methods and option pricing



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methodology. We expect that adoption of this statement will have a material impact on our consolidated financial statements. The pro forma impact on our net
income (loss) for the years ended December 31, 2005, 2004 and 2003 of additional expense of $1.4 million, $2.6 million and $7.6 million, respectively, may not be indicative of the results from the valuation methodologies ultimately adopted and
of the differences between SFAS 123 and SFAS 123R.



In November
2005, the FASB issued FASB Staff Position SFAS 123(R)-3, Transition Election Related to Accounting for the Tax Effects of Share-based Payment Awards, that provides an elective alternative transition method of calculating the pool of excess
tax benefits available to absorb tax deficiencies recognized subsequent to the adoption of SFAS 123R (the APIC Pool) to the method otherwise required by paragraph 81 of SFAS 123R. We may take up to one year from the effective date of the
FSP to evaluate our available alternatives and make our one-time election. We are currently evaluating the alternative methods in connection with our adoption of SFAS123R.



In November 2005, the FASB issued FASB Staff Position SFAS 115-1, The Meaning of Other-than-Temporary Impairment and Its
Application to Certain Investments (FSP 115-1).This statement supersedes EITF Issue No. 03-1 and EITF Abstracts Topic No. D-44. This statement summarizes the accounting and disclosure guidance on other-than-temporary impairments of
securities. We must adopt FSP 115-1 no later than January 1, 2006. While we are currently evaluating the impact of this statement, we do not expect that adoption of this statement will have a material impact on our consolidated financial
statements.



In May 2005, the FASB issued SFAS No. 154,
Accounting Changes and Error Corrections, (SFAS 154). SFAS 154 replaces APB No. 20, Accounting Changes, and FAS 3, Reporting Changes in Interim Financial Statements. SFAS 154 changes the accounting for, and
reporting of, a change in accounting principle. FAS 154 requires retrospective application to the prior periods financial statements of voluntary changes in accounting principle and changes required by new accounting standards when the
standard does not include specific transition provisions, unless it is impractical to do so. SFAS 154 is effective for accounting changes and corrections of errors in fiscal years beginning after December 15, 2005. While we are currently
evaluating the impact of this statement, we do not expect that adoption of this statement will have a material impact on our consolidated financial statements.



Off-Balance Sheet Arrangements



We do not have any off-balance sheet arrangements.



|ITEM 7A.    QUANTITATIVE | AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
|------------------------ | ---------------------------------------------



Our holdings of financial instruments are primarily comprised of a mix of U.S. corporate debt, government securities and commercial paper. All such
instruments are classified as securities available for sale. Our debt security portfolio represents funds held temporarily pending use in our business and operations. We manage these funds accordingly. Our primary investment objective is the
preservation of principal, while at the same time maximizing the generation of investment income. We seek reasonable assuredness of the safety of principal and market liquidity by investing in cash equivalents (such as Treasury bills and money
market funds) and fixed income securities (such as U.S. government and agency securities, municipal securities, taxable municipals, and corporate notes) while at the same time seeking to achieve a favorable rate of return. Our market risk exposure
consists principally of exposure to changes in interest rates. Our holdings are also exposed to the risks of changes in the credit quality of issuers. Historically, we have typically invested in financial instruments with maturities of less than one
year. The carrying amount, which approximates fair value, and the annualized weighted average nominal interest rate of our investment portfolio at December 31, 2005, was approximately $1.2 million and 2.6%, respectively. A one percent change in
the interest rate would have resulted in a $0.5 million impact to interest income for the year ended December 31, 2005.



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At December 31, 2005, we had outstanding $78.9 million of our subordinated convertible notes. The
subordinated convertible notes were convertible into shares of our common stock at a price of $109 per share, subject to certain adjustments. The subordinated convertible notes bear interest at a rate of 6% per annum, payable semi-annually in
arrears, and could be redeemed by us, at certain premiums over the principal amount. At December 31, 2005, the fair value of our subordinated convertible notes was approximately $79.3 million, based on quoted market prices. The fair value of
our subordinated convertible notes is dependent upon, among other factors, the fair value of our common stock and prevailing market interest rates. On March 1, 2006, we redeemed the remaining $78.9 million principal amount of subordinated
convertible notes. This eliminated all long-term debt that was outstanding on December 31, 2005.



|ITEM 8.    FINANCIAL | STATEMENTS AND SUPPLEMENTARY DATA
|-------------------- | ---------------------------------



Our financial statements required by this item are attached to this Report beginning on page 65.



|ITEM 9.    CHANGES | IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE
|------------------ | ----------------------------------------------------------------------------



Not Applicable.



|ITEM 9A.    CONTROLS | AND PROCEDURES
|-------------------- | --------------



Evaluation of Disclosure Controls and Procedures



An evaluation was performed under the supervision and with the participation of our management, including our Chief Executive Officer, or CEO, and our Chief Financial Officer, or CFO, of the effectiveness of our
disclosure controls and procedures, as such term is defined under Rule 13a-15(e) promulgated under the Securities Exchange Act of 1934, as amended (the Exchange Act), as of December 31, 2005. Based on that evaluation, our
management, including our CEO and CFO, concluded that as of December 31, 2005 our disclosure controls and procedures were effective to ensure that information required to be disclosed by us in reports that we file or submit under the Exchange
Act, is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the Securities and Exchange Commission and that such information is accumulated and communicated to the Companys management,
including our CEO and CFO, as appropriate to allow timely decisions regarding required disclosure.



Changes in Internal Control over Financial Reporting



During the quarter ended December 31, 2005, we continued to implement new controls over net product sales, cost of sales and other transactions related to the commercial operations resulting from the 2004
acquisition of Vancocin. Also, during the quarter ended December 31, 2005, as a result of our 2005 income tax status, we implemented new controls over income tax reporting. This was required due to our having taxable income in 2005 and our
release of a portion of our valuation allowance on deferred tax assets. Prior to the fourth quarter of 2005, our net deferred tax assets were fully offset by a valuation allowance. Other than these controls, there were no significant changes in our
internal control over financial reporting identified in connection with the evaluation of such controls that occurred during our most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect our internal
control over financial reporting.



Management Report on Internal Control
over Financial Reporting



Our management is responsible
for establishing and maintaining adequate internal control over financial reporting. Our internal control system was designed to provide reasonable assurance to the companys management and board of directors regarding the preparation and fair
presentation of published consolidated financial statements. Internal control over financial reporting is defined in Rule 13a-15(f) or 15d-15(f)



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promulgated under the Exchange Act as a process designed by, or under the supervision of, the companys principal executive and principal financial
officers and effected by the companys board of directors, management and other personnel, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in
accordance with generally accepted accounting principles and includes those policies and procedures that:



| | · |  | pertain to the maintenance of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of the assets of the company;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles,
and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · |  | provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the companys assets that could have a material effect
on the financial statements.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Our management,
including our Chief Executive Officer and Chief Financial Officer, do not expect that our internal control over financial reporting will prevent all error and all fraud. A control system, no matter how well designed and implemented, can provide only
reasonable, not absolute, assurance that the control systems objectives will be met. Further, the design of a control system must reflect the fact that there are resource constraints, and the benefits of controls must be considered relative to
their costs. Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that all control issues within a company are detected. The inherent limitations include the realities that judgments in
decision-making can be faulty, and that breakdowns can occur because of simple errors or mistakes. Controls can also be circumvented by the individual acts of some persons, by collusion of two or more people or by management override of the
controls. Because of the inherent limitations in a cost-effective control system, misstatements due to error or fraud may occur and may not be detected.



Our management assessed the effectiveness of its internal control over financial reporting as of December 31, 2005. In making this assessment, it
used the criteria based on the framework set forth by the Committee of Sponsoring Organizations of the Treadway Commission in Internal Control  Integrated Framework (COSO). Based on our assessments we believe that, as of
December 31, 2005, our internal control over financial reporting is effective based on those criteria.



Our independent registered public accounting firm, KPMG LLP, has issued an audit report on our assessment of our internal control over financial
reporting. Their report on managements assessment and their opinion on the effectiveness of the Companys internal control over financial reporting appears on the next page.



59



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Report of Independent Registered Public Accounting Firm



The Board of Directors and Stockholders

ViroPharma Incorporated:



We have audited managements assessment, included in the accompanying Management Report on Internal Control Over Financial Reporting,
that ViroPharma Incorporated and subsidiaries (the Company) maintained effective internal control over financial reporting as of December 31, 2005, based on criteria established in Internal ControlIntegrated Framework issued by the
Committee of Sponsoring Organizations of the Treadway Commission (COSO). The Companys management is responsible for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of internal control
over financial reporting. Our responsibility is to express an opinion on managements assessment and an opinion on the effectiveness of the Companys internal control over financial reporting based on our audit.



We conducted our audit in accordance with the standards of the Public Company
Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our
audit included obtaining an understanding of internal control over financial reporting, evaluating managements assessment, testing and evaluating the design and operating effectiveness of internal control, and performing such other procedures
as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.



A companys internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial
reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A companys internal control over financial reporting includes those polices and procedures that
(1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as
necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors
of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the companys assets that could have a material effect on the financial statements.



Because of its inherent limitations, internal control over
financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of
compliance with the policies or procedures may deteriorate.



In
our opinion, managements assessment that the Company maintained effective internal control over financial reporting as of December 31, 2005, is fairly stated, in all material respects, based on criteria established in Internal
ControlIntegrated Framework issued by COSO. Also, in our opinion, the Company maintained, in all material respects, effective internal control over financial reporting as of December 31, 2005, based on the criteria established in Internal
ControlIntegrated Framework issued by COSO.



We also have
audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the consolidated balance sheets of ViroPharma Incorporated and subsidiaries as of December 31, 2005 and 2004, and the related
consolidated statements of operations, comprehensive income (loss), stockholders equity (deficit), and cash flows for each of the years in the three-year period ended December 31, 2005, and our report dated March 2, 2006 expressed an
unqualified opinion on those consolidated financial statements.



/s/ KPMG LLP



Philadelphia, Pennsylvania

March 2, 2006



60



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##### Table of Contents

|ITEM 9B.    OTHER | INFORMATION
|----------------- | -----------



Not Applicable.



61



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##### Table of Contents

PART III



|ITEM 10.    DIRECTORS | AND EXECUTIVE OFFICERS OF THE REGISTRANT
|--------------------- | ----------------------------------------



The information concerning our directors and regarding compliance with Section 16 of the Securities Exchange Act of 1934 required by this Item will
be set forth in our Proxy Statement, to be filed within 120 days after the end of the fiscal year covered by this Annual Report on Form 10-K, and is incorporated by reference to our Proxy Statement.



The information concerning our executive officers required by this Item is
incorporated by reference herein to the section of this Annual Report in Part I entitled Executive Officers of the Registrant.



|ITEM 11.    EXECUTIVE | COMPENSATION
|--------------------- | ------------



The information required by this Item will be set forth in our Proxy Statement, to be filed within 120 days after the end of the fiscal year covered by
this Annual Report on Form 10-K, and is incorporated by reference to our Proxy Statement.



|ITEM 12.    SECURITY | OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT   AND RELATED STOCKHOLDER MATTERS
|-------------------- | ---------------------------------------------------------------------------------------



The information required by this Item will be set forth in our Proxy Statement, to be filed within 120 days after the end of
the fiscal year covered by this Annual Report on Form 10-K, and is incorporated by reference to our Proxy Statement.



|ITEM 13.    CERTAIN | RELATIONSHIPS AND RELATED TRANSACTIONS
|------------------- | --------------------------------------



The information required by this Item will be set forth in our Proxy Statement, to be filed within 120 days after the end of the fiscal year covered by
this Annual Report on Form 10-K, and is incorporated by reference to our Proxy Statement.



|ITEM 14.    PRINCIPAL | ACCOUNTING FEES AND SERVICES
|--------------------- | ----------------------------



The information required by this Item will be set forth in our Proxy Statement, to be filed within 120 days after the end of the fiscal year covered by
this Annual Report on Form 10-K, and is incorporated by reference to our Proxy Statement.



62



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PART IV



ITEM 15.    EXHIBITS, FINANCIAL STATEMENT SCHEDULES



|            |  |                                                                                                                                                                                                                                                                                                                                
|----------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Description                                                                                                                                                                                                                                                                                                                    
|            | 
|3.1         |  | Amended and Restated Certificate of Incorporation of the Company, as amended by a Certificate of Amendment of Amended and Restated Certificate of Incorporation dated May 18, 1999, as further
amended by a Certificate of Amendment of Amended and Restated Certificate of Incorporation dated May 24, 2000. (1) (Exhibit 3.1)
|            | 
|3.2         |  | Certificate of Designation establishing and designating the Series A Junior Participating Preferred Shares. (2) (Exhibit 3.2)                                                                                                                                                                                                  
|            | 
|3.3         |  | Amended and Restated By-Laws of the Company. (4) (Exhibit 3.3)                                                                                                                                                                                                                                                                 
|            | 
|4.1         |  | Rights Agreement, dated as of September 10, 1998, between ViroPharma Incorporated and StockTrans, Inc., as Rights Agent. (3) (Exhibit 4.1)                                                                                                                                                                                     
|            | 
|4.2         |  | Amendment No. 1 to Rights Agreement. (5) (Exhibit 4.2)                                                                                                                                                                                                                                                                         
|            | 
|4.3         |  | Amendment No. 2 to Rights Agreement. (5) (Exhibit 4.1)                                                                                                                                                                                                                                                                         
|            | 
|4.4         |  | Indenture dated as of March 1, 2000 of ViroPharma Incorporated to Summit Bank as Trustee (including the form of note). (7) (Exhibit 4.3)                                                                                                                                                                                       
|            | 
|4.5         |  | Senior Notes Indenture dated October 18, 2004 of ViroPharma Incorporated to U.S. Bank National Association as Trustee (including form of Senior Note). (19) (Exhibit 99.6)                                                                                                                                                     
|            | 
|4.6         |  | Convertible Notes Indenture dated October 18, 2004 of ViroPharma Incorporated to U.S. Bank National Association as Trustee (including form of Convertible Note). (19) (Exhibit
99.7)                                                                                                                                           
|            | 
|4.7         |  | Supplemental Indenture No. 1 to Convertible Notes Indenture dated October 18, 2004 of ViroPharma Incorporated to U.S. Bank National Association as Trustee. (9) (Exhibit 99.7)                                                                                                                                                 
|            | 
|10.1      |  | Form of Employment Agreement. (25) (Exhibit 10.1)                                                                                                                                                                                                                                                                              
|            | 
|10.2        |  | Form of Indemnification Agreement. (25) (Exhibit 10.2)                                                                                                                                                                                                                                                                         
|            | 
|10.3        |  | Lease Termination Agreement, effective as of March 31, 2005, between the Company and The Hankin Group. (26) (Exhibit 10.1)                                                                                                                                                                                                     
|            | 
|10.4        |  | Investment Agreement among ViroPharma Incorporated and Perseus-Soros Biopharmaceutical Fund, L.P. dated May 5, 1999. (5) (Exhibit 10.21)                                                                                                                                                                                       
|            | 
|10.5       |  | Stock Purchase Agreement dated December 9, 1999 between American Home Products Corporation and ViroPharma Incorporated. (6) (Exhibit 10.26)                                                                                                                                                                                    
|            | 
|10.6      |  | Severance Agreement dated August 21, 2000 between ViroPharma Incorporated and Michel de Rosen. (10) (Exhibit 10.31)                                                                                                                                                                                                            
|            | 
|10.7       |  | First Amended and Restated Agreement dated February 27, 2001 between Sanofi-Synthelabo and ViroPharma Incorporated. (11) (Exhibit 10.32)                                                                                                                                                                                       
|            | 
|10.8        |  | Stock Purchase Agreement dated as of September 9, 2001 between ViroPharma Incorporated and Aventis Pharma Inc. (12) (Exhibit 10.36)                                                                                                                                                                                            
|            | 
|10.9        |  | Agreement of Lease dated as of September 24, 2001 between LV Associates, L.P. and ViroPharma Incorporated. (12) (Exhibit 10.37)                                                                                                                                                                                                
|            | 
|10.10     |  | 2001 Equity Incentive Plan. (13) (Exhibit 10.33)                                                                                                                                                                                                                                                                               
|            | 
|10.11       |  | Letter Agreement between ViroPharma Incorporated and Wyeth dated May 29, 2002. (14) (Exhibit 10.35)                                                                                                                                                                                                                            
|            | 
|10.12     |  | Amended and Restated ViroPharma Incorporated Employee Stock Purchase Plan. (15)                                                                                                                                                                                                                                                



63



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##### Table of Contents

|            |  |                                                                                                                                                                                   
|----------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Description                                                                                                                                                                       
|            | 
|10.13*    |  | Form of Change of Control Agreement between ViroPharma and certain of its employees.                                                                                              
|            | 
|10.14      |  | First Amended and Restated Collaboration and License Agreement dated June 26, 2003 between ViroPharma Incorporated and Wyeth. (16) (Exhibit 10.33)                                
|            | 
|10.15      |  | Amendment to Stock Purchase Agreement dated June 26, 2003 between ViroPharma Incorporated and Wyeth. (16) (Exhibit 10.34)                                                         
|            | 
|10.16      |  | License Agreement dated August 8, 2003 by and between GlaxoSmithKline and ViroPharma Incorporated. (4) (Exhibit 10.35)                                                            
|            | 
|10.17      |  | Letter Agreement dated November 24, 2003 between Sanofi-Synthelabo and the Company. (17) (Exhibit 10.34)                                                                          
|            | 
|10.18       |  | Securities Purchase Agreement dated October 18, 2004 by and among ViroPharma Incorporated and the Buyers. (18) (Exhibit 99.2)                                                     
|            | 
|10.19       |  | Convertible Notes Registration Rights Agreement dated October 18, 2004 by and among ViroPharma Incorporated and the Buyers. (18) (Exhibit 99.4)                                   
|            | 
|10.20       |  | Amendment to Convertible Notes Registration Rights Agreement dated May 6, 2005 by and among ViroPharma Incorporated and the Buyers. (9) (Exhibit 10.1)                            
|            | 
|10.21       |  | Senior Notes Registration Rights Agreement dated October 18, 2004 by and among ViroPharma Incorporated and the Buyers. (18) (Exhibit 99.3)                                        
|            | 
|10.22       |  | Pledge and Collateral Agreement to U.S. Bank National Association as Trustee, and U.S. Bank National Association, as Collateral Agent for the Secured Parties. (18) (Exhibit
99.5)
|            | 
|10.23       |  | Form of Warrant to Purchase shares of Common Stock. (18) (Exhibit 99.8)                                                                                                           
|            | 
|10.24      |  | Assignment, Transfer and Assumption Agreement between ViroPharma Incorporated and Eli Lilly and Company dated October 18, 2004.(19) (Exhibit 2.1)                                 
|            | 
|10.25      |  | Amendment No. 1 to the Assignment, Transfer and Assumption Agreement between ViroPharma Incorporated and Eli Lilly and Company dated November 8, 2004.(19) (Exhibit 2.2)          
|            | 
|10.26      |  | Manufacturing Agreement between ViroPharma Incorporated and Eli Lilly and Company dated October 18, 2004. (19) (Exhibit 10.1)                                                     
|            | 
|10.27*     |  | Amendment to Manufacturing Agreement between ViroPharma Incorporated and Eli Lilly and Company dated November 2, 2005.                                                            
|            | 
|10.28      |  | Transition Services Agreement between ViroPharma Incorporated and Eli Lilly and Company dated November 8, 2004. (19) (Exhibit 10.2)                                               
|            | 
|10.29      |  | Security Agreement between ViroPharma Incorporated and U.S. Bank National Association dated November 8, 2004. (19) (Exhibit 10.3)                                                 
|            | 
|10.30      |  | Amendment to Security Agreement between ViroPharma Incorporated and U.S. Bank National Association dated May 6, 2005. (9) (Exhibit 10.2)                                          
|            | 
|10.31      |  | Cooperation Agreement between ViroPharma Incorporated and Eli Lilly and Company dated October 18, 2004. (19) (Exhibit 10.4)                                                       
|            | 
|10.32      |  | License Agreement between ViroPharma Incorporated and Schering Corporation dated November 3, 2004. (20) (Exhibit 2.1)                                                             
|            | 
|10.33     |  | ViroPharma Severance Plan. (25) (Exhibit 10.37)                                                                                                                                   
|            | 
|10.34     |  | ViroPharma Cash Bonus Plan. (21) (Exhibit 10.1)                                                                                                                                   
|            | 
|10.35     |  | ViroPharma Board Compensation Policy. (22) (Exhibit 10.1)                                                                                                                         
|            | 
|10.36     |  | Amended and Restated 1995 ViroPharma Stock Option and Restricted Share Plan. (23)                                                                                                 



64



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##### Table of Contents

|            |  |                                                                                                                                                         
|----------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Description                                                                                                                                             
|            | 
|10.37     |  | 2005 ViroPharma Stock Option and Restricted Share Plan. (27)                                                                                            
|            | 
|10.38     |  | Form Of Non-Qualified Stock Option Agreement For Member Of The Board Of Director. (28)                                                                  
|            | 
|10.39     |  | Form Of Non-Qualified Stock Option Agreement. (28)                                                                                                      
|            | 
|10.41*     |  | Master Agreement by and between OSG Norwich Pharmaceuticals, Inc. and ViroPharma Incorporated effective as of December 1, 2005.                         
|            | 
|10.42*     |  | Project Agreement No. 1 by and between OSG Norwich Pharmaceuticals, Inc. and ViroPharma Incorporated.                                                   
|            | 
|12.1*       |  | Schedule of Ratio of Earnings to Fixed Charges.                                                                                                         
|            | 
|14          |  | Code of Conduct and Ethics. (17)(Exhibit 14)                                                                                                            
|            | 
|21*         |  | List of Subsidiaries.                                                                                                                                   
|            | 
|23*         |  | Consent of KPMG LLP, Independent Registered Public Accounting Firm.                                                                                     
|            | 
|24*         |  | Power of Attorney (included on signature page).                                                                                                         
|            | 
|31.1*       |  | Certification by Chief Executive Officer pursuant to Rule 13a-14(a) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
|            | 
|31.2*       |  | Certification by Chief Financial Officer pursuant to Rule 13a-14(a) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
|            | 
|32.1*       |  | Certification Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                 

---

|* |  | Filed herewith.
|- |  | ---------------

| |  | Portions of this exhibit were omitted and filed separately with the Secretary of the Commission pursuant to an application for confidential treatment filed with the Commission
pursuant to Rule 24b-2 under the Securities Exchange Act of 1934, as amended.
|- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| |  | Compensation plans and arrangements for executives and others.
|-- |  | --------------------------------------------------------------

|(1) |  | Filed as an Exhibit to Registrants Form 10-Q for the quarter ended June 30, 2000.
|--- |  | ----------------------------------------------------------------------------------

|(2) |  | Filed as an Exhibit to Registrants Form 10-K for the year ended December 31, 1998.
|--- |  | -----------------------------------------------------------------------------------

|(3) |  | Filed as an Exhibit to the Companys Current Report on Form 8-K filed with the Commission on September 21, 1998.
|--- |  | ----------------------------------------------------------------------------------------------------------------

|(4) |  | Filed as an Exhibit to Registrants Form 10-Q for the quarter ended September 30, 2003.
|--- |  | ---------------------------------------------------------------------------------------

|(5) |  | Filed as an Exhibit to the Companys Current Report on Form 8-K filed with the Commission on May 3, 2005.
|--- |  | ---------------------------------------------------------------------------------------------------------

|(6) |  | Filed as an Exhibit to Registrants Form 10-K for the year ended December 31, 1999.
|--- |  | -----------------------------------------------------------------------------------

|(7) |  | Filed as an Exhibit to Registrants Form 10-Q for the quarter ended March 31, 2000.
|--- |  | -----------------------------------------------------------------------------------

|(8) |  | Filed as an Exhibit to Registration Statement on Form S-3 (File No. 333-37960), as amended, initially filed on May 26, 2000.
|--- |  | ----------------------------------------------------------------------------------------------------------------------------

|(9) |  | Filed as an Exhibit to the Companys Current Report on Form 8-K filed with the Commission on May 10, 2005.
|--- |  | ----------------------------------------------------------------------------------------------------------

|(10) |  | Filed as an Exhibit to Registrants Form 10-Q for the quarter ended September 30, 2000.
|---- |  | ---------------------------------------------------------------------------------------

|(11) |  | Filed as an Exhibit to Registrants Form 10-Q for the quarter ended March 31, 2001.
|---- |  | -----------------------------------------------------------------------------------

|(12) |  | Filed as an Exhibit to Registrants Form 10-Q for the quarter ended September 30, 2001.
|---- |  | ---------------------------------------------------------------------------------------

|(13) |  | Filed as an Exhibit to Registrants Form 10-K for the year ended December 31, 2001.
|---- |  | -----------------------------------------------------------------------------------

|(14) |  | Filed as an Exhibit to Registrants Form 10-Q for the quarter ended June 30, 2002.
|---- |  | ----------------------------------------------------------------------------------

|(15) |  | Filed as an Annex to Registrants Proxy Statement filed with the Commission on March 27, 2003.
|---- |  | ----------------------------------------------------------------------------------------------

|(16) |  | Filed as an Exhibit to Registrants Form 10-Q for the quarter ended June 30, 2003.
|---- |  | ----------------------------------------------------------------------------------

|(17) |  | Filed as an Exhibit to Registrants Form 10-K for the year ended December 31, 2004.
|---- |  | -----------------------------------------------------------------------------------

|(18) |  | Filed as an Exhibit to the Companys Current Report on Form 8-K filed with the Commission on October 19, 2004.
|---- |  | --------------------------------------------------------------------------------------------------------------



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##### Table of Contents

|(19) |  | Filed as an Exhibit to the Companys Current Report on Form 8-K filed with the Commission on November 24, 2004.
|---- |  | ---------------------------------------------------------------------------------------------------------------

|(20) |  | Filed as an Exhibit to the Companys Current Report on Form 8-K filed with the Commission on November 29, 2004.
|---- |  | ---------------------------------------------------------------------------------------------------------------

|(21) |  | Filed as an Exhibit to the Companys Current Report on Form 8-K filed with the Commission on January 25, 2005.
|---- |  | --------------------------------------------------------------------------------------------------------------

|(22) |  | Filed as an Exhibit to the Companys Current Report on Form 8-K filed with the Commission on February 15, 2005.
|---- |  | ---------------------------------------------------------------------------------------------------------------

|(23) |  | Filed as an Annex to Registrants Proxy Statement filed with the Commission on April 8, 2002.
|---- |  | ---------------------------------------------------------------------------------------------

|(24) |  | Filed as an Exhibit to Registration Statement on Form S-3 (File No. 333-30005) filed on January 26, 2005.
|---- |  | ---------------------------------------------------------------------------------------------------------

|(25) |  | Filed as an Exhibit to Registrants Form 10-K for the year ended December 31, 2004.
|---- |  | -----------------------------------------------------------------------------------

|(26) |  | Filed as an Exhibit to the Companys Current Report on Form 8-K filed with the Commission on April 8, 2005.
|---- |  | -----------------------------------------------------------------------------------------------------------

|(27) |  | Filed as an Annex to Registrants Proxy Statement filed with the Commission on March 31, 2005.
|---- |  | ----------------------------------------------------------------------------------------------

|(28) |  | Filed as an Exhibit to Registrants Form 10-Q for the quarter ended June 20, 2005.
|---- |  | ----------------------------------------------------------------------------------



Copies of the exhibits are available to stockholders from Thomas F. Doyle, Vice President, General Counsel and Secretary,
ViroPharma Incorporated, 397 Eagleview Boulevard, Exton, Pennsylvania 19341. There will be a fee to cover the Companys expenses in furnishing the exhibits.



66



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##### Table of Contents

SIGNATURES



Pursuant to the
requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on our behalf by the undersigned, thereunto duly authorized.



VIROPHARMA INCORPORATEDBy:

/s/    MICHEL de ROSENMichel de Rosen President, Chief Executive Officer




POWER OF
ATTORNEY



KNOW ALL PERSONS BY THESE PRESENTS, that each
person whose signature appears below constitutes and appoints each of Michel de Rosen and Vincent J. Milano as his or her attorney-in-fact, with the full power of substitution, for him or her in any and all capacities, to sign any amendments to this
Report, and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming all that said attorney-in-fact, or his substitute or substitutes, may do or
cause to be done by virtue hereof.



Pursuant to the
requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated:



|                                                          |  |                                                                                                                             |  |              
|--------------------------------------------------------- |  | --------------------------------------------------------------------------------------------------------------------------- |  | -------------
|Name                                                      |  | Capacity                                                                                                                    |  | Date         
|                                                          |  |                                                                                                                            
|/s/    MICHEL de ROSENMichel de Rosen                     |  | President, Chief Executive Officer(Principal Executive Officer)                                                             |  | March 1, 2006
|                                                          |  |                                                                                                                            
|/s/    VINCENT J.
MILANOVincent J.
Milano                 |  | Vice President, Chief Operating Officer, Chief Financial Officer and Treasurer (Principal Financial and Accounting Officer) |  | March 1, 2006
|                                                          |  |                                                                                                                            
|/s/    MICHEL de ROSENMichel de Rosen                     |  | Chairman of the Board                                                                                                       |  | March 1, 2006
|                                                          |  |                                                                                                                            
|/s/    FRANK BALDINO, JR.,
PH.D.Frank Baldino, Jr.,
Ph.D. |  | Director                                                                                                                    |  | March 1, 2006
|                                                          |  |                                                                                                                            
|/s/    PAUL A. BROOKEPaul A. Brooke                       |  | Director                                                                                                                    |  | March 1, 2006
|                                                          |  |                                                                                                                            
|/s/    WILLIAM CLAYPOOL,
M.D.William Claypool, M.D.       |  | Director                                                                                                                    |  | March 1, 2006
|                                                          |  |                                                                                                                            
|/s/    MICHAEL R.
DOUGHERTYMichael R.
Dougherty           |  | Director                                                                                                                    |  | March 1, 2006
|                                                          |  |                                                                                                                            
|/s/    ROBERT J.
GLASERRobert J.
Glaser                   |  | Director                                                                                                                    |  | March 1, 2006
|                                                          |  |                                                                                                                            
|/s/    JOHN R. LEONEJohn R. Leone                         |  | Director                                                                                                                    |  | March 1, 2006



67



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ViroPharma Incorporated



Index to Consolidated Financial Statements



|                                                                                                               |  |     
|-------------------------------------------------------------------------------------------------------------- |  | ----
|                                                                                                               |  | Page
|Report of Independent Registered Public Accounting Firm                                                        |  | 69  
|Consolidated Balance Sheets at December 31, 2005 and 2004                                                      |  | 70  
|Consolidated Statements of Operations for the years ended December 31, 2005, 2004 and 2003                     |  | 71  
|Consolidated Statements of Comprehensive Income (Loss) for the years ended December 31, 2005, 2004 and 2003    |  | 72  
|Consolidated Statements of Stockholders Equity (Deficit) for the years ended December 31, 2005, 2004 and 2003 |  | 73  
|Consolidated Statements of Cash Flows for the years ended December 31, 2005, 2004 and 2003                     |  | 74  
|Notes to Consolidated Financial Statements                                                                     |  | 75  



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Report of Independent Registered Public Accounting Firm



The Board of Directors and Stockholders

ViroPharma Incorporated:



We
have audited the accompanying consolidated balance sheets of ViroPharma Incorporated and subsidiaries as of December 31, 2005 and 2004, and the related consolidated statements of operations, comprehensive income (loss), stockholders
equity (deficit) and cash flows for each of the years in the three-year period ended December 31, 2005. These consolidated financial statements are the responsibility of the Companys management. Our responsibility is to express an opinion
on these consolidated financial statements based on our audits.



We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial
statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant
estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.



In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the
financial position of ViroPharma Incorporated and subsidiaries as of December 31, 2005 and 2004, and the results of their operations and their cash flows for each of the years in the three-year period ended December 31, 2005, in conformity
with U.S generally accepted accounting principles.



We have
also audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the effectiveness of ViroPharma Incorporated and subsidiaries internal control over financial reporting as of December 31,
2005, based on criteria established in Internal Control-Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO), and our report dated March 2, 2006 expressed an unqualified opinion on
managements assessment of, and the effective operation of, internal control over financial reporting.



/s/ KPMG LLP



Philadelphia, Pennsylvania

March 2, 2006



69



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##### Table of Contents

ViroPharma Incorporated

Consolidated Balance Sheets



|                                                                                                                                                                                  |  |              |          |   |      |   |          |  
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ | -------- | - | ---- | - | -------- | -
|                                                                                                                                                                                  |  | December 31, |         
|(in thousands, except share and per share data)                                                                                                                                   |  | 2005         |          |   | 2004 |  
|Assets                                                                                                                                                                            |  |              |          |   |      |   |          |  
|Current assets:                                                                                                                                                                   |  |              |          |   |      |   |          |  
|Cash and cash equivalents                                                                                                                                                         |  | $            | 232,195  |   |      | $ | 22,993   |  
|Short-term investments                                                                                                                                                            |  |              | 1,218    |   |      |   | 12,184   |  
|Restricted cash equivalents                                                                                                                                                       |  |              |         |   |      |   | 9,033    |  
|Accounts receivable, net                                                                                                                                                          |  |              | 14,887   |   |      |   | 9,170    |  
|Inventory                                                                                                                                                                         |  |              | 10,996   |   |      |   | 1,022    |  
|Income taxes receivable                                                                                                                                                           |  |              | 1,977    |   |      |   |         |  
|Deferred income taxes                                                                                                                                                             |  |              | 11,644   |   |      |   |         |  
|Other current assets                                                                                                                                                              |  |              | 1,912    |   |      |   | 1,630    |  
|                                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Total current assets                                                                                                                                                              |  |              | 274,829  |   |      |   | 56,032   |  
|Intangible assets, net                                                                                                                                                            |  |              | 121,691  |   |      |   | 116,359  |  
|Equipment and leasehold improvements, net                                                                                                                                         |  |              | 1,555    |   |      |   | 1,503    |  
|Deferred income taxes                                                                                                                                                             |  |              | 36,875   |   |      |   |         |  
|Debt issue costs, net                                                                                                                                                             |  |              | 526      |   |      |   | 4,372    |  
|Other assets                                                                                                                                                                      |  |              | 49       |   |      |   | 94       |  
|                                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Total assets                                                                                                                                                                      |  | $            | 435,525  |   |      | $ | 178,360  |  
|                                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Liabilities and Stockholders Equity (Deficit)                                                                                                                                    |  |              |          |   |      |   |          |  
|Current liabilities:                                                                                                                                                              |  |              |          |   |      |   |          |  
|Accounts payable                                                                                                                                                                  |  | $            | 9,256    |   |      | $ | 791      |  
|Due to partners                                                                                                                                                                   |  |              | 21       |   |      |   | 412      |  
|Accrued expenses and other current liabilities                                                                                                                                    |  |              | 19,402   |   |      |   | 11,347   |  
|Current portion of long-term debt                                                                                                                                                 |  |              | 78,920   |   |      |   |         |  
|Deferred revenuecurrent                                                                                                                                                          |  |              | 564      |   |      |   | 564      |  
|                                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Total current liabilities                                                                                                                                                         |  |              | 108,163  |   |      |   | 13,114   |  
|Long-term debt, net of debt discount                                                                                                                                              |  |              |         |   |      |   | 190,400  |  
|Deferred revenuenoncurrent                                                                                                                                                       |  |              |         |   |      |   | 563      |  
|Other liabilities                                                                                                                                                                 |  |              | 385      |   |      |   | 421      |  
|                                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Total liabilities                                                                                                                                                                 |  |              | 108,548  |   |      |   | 204,498  |  
|                                                                                                                                                                                  |  |              |          |   |      |   |          |  
|                                                                                                                                                                                  |  |             
|Commitments and Contingencies (Notes 6, 9 and 15)Stockholders equity (deficit):                                                                                                  |  |              |          |   |      |   |          |  
|Preferred stock, par value $0.001 per share. 5,000,000 shares authorized; Series A convertible participating preferred stock; no shares issued
and outstanding                    |  |              |         |   |      |   |         |  
|Series A junior participating preferred stock, par value $0.001 per share.                                                                                                        |  |              |          |   |      |   |          |  
|200,000 shares designated; no shares issued and outstanding                                                                                                                       |  |              |         |   |      |   |         |  
|Common stock, par value $0.002 per share. 100,000,000 shares authorized; issued and outstanding 68,563,879 shares at December 31, 2005
and 26,758,495 shares at December 31, 2004 |  |              | 137      |   |      |   | 54       |  
|Additional paid-in capital                                                                                                                                                        |  |              | 490,593  |   |      |   | 250,776  |  
|Deferred compensation                                                                                                                                                             |  |              | (3       | ) |      |   | (10      | )
|Accumulated other comprehensive (loss) income                                                                                                                                     |  |              | (350     | ) |      |   | 147      |  
|Accumulated deficit                                                                                                                                                               |  |              | (163,400 | ) |      |   | (277,105 | )
|                                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Total stockholders equity (deficit)                                                                                                                                              |  |              | 326,977  |   |      |   | (26,138  | )
|                                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Total liabilities and stockholders equity                                                                                                                                        |  | $            | 435,525  |   |      | $ | 178,360  |  
|                                                                                                                                                                                  |  |              |          |   |      |   |          |  





See accompanying notes to consolidated financial statements.



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##### Table of Contents

ViroPharma Incorporated

Consolidated Statements of Operations



|                                                             |  |                         |         |   |      |   |         |      |  |   |         |  
|------------------------------------------------------------ |  | ----------------------- | ------- | - | ---- | - | ------- | ---- |  | - | ------- | -
|                                                             |  | Year ended December 31, |        
|                                                             |  | 2005                    |         |   | 2004 |   |         | 2003 | 
|(in thousands, except per share data)                        |  |                         |         |   |      |   |         |      |  |   |         |  
|Revenues:                                                    |  |                         |         |   |      |   |         |      |  |   |         |  
|Net product sales                                            |  | $                       | 125,853 |   |      | $ | 8,348   |      |  | $ |        |  
|License fee and milestone revenue                            |  |                         | 6,564   |   |      |   | 13,070  |      |  |   | 1,084   |  
|Grant and other revenue                                      |  |                         |        |   |      |   | 971     |      |  |   | 528     |  
|                                                             |  |                         |         |   |      |   |         |      |  |   |         |  
|Total revenues                                               |  |                         | 132,417 |   |      |   | 22,389  |      |  |   | 1,612   |  
|                                                             |  |                         |         |   |      |   |         |      |  |   |         |  
|Costs and Expenses:                                          |  |                         |         |   |      |   |         |      |  |   |         |  
|Cost of sales                                                |  |                         | 18,029  |   |      |   | 1,717   |      |  |   |        |  
|Research and development                                     |  |                         | 10,610  |   |      |   | 16,388  |      |  |   | 23,043  |  
|Marketing, general and administrative                        |  |                         | 10,475  |   |      |   | 15,643  |      |  |   | 9,035   |  
|Intangible amortization and acquisition of technology rights |  |                         | 5,158   |   |      |   | 650     |      |  |   | 3,500   |  
|                                                             |  |                         |         |   |      |   |         |      |  |   |         |  
|Total costs and expenses                                     |  |                         | 44,272  |   |      |   | 34,398  |      |  |   | 35,578  |  
|                                                             |  |                         |         |   |      |   |         |      |  |   |         |  
|Operating income (loss)                                      |  |                         | 88,145  |   |      |   | (12,009 | )    |  |   | (33,966 | )
|                                                             |  |                         |        
|Other Income (Expense):                                      |  |                         |         |   |      |   |         |      |  |   |         |  
|Change in fair value of derivative liability                 |  |                         | (4,044  | ) |      |   |        |      |  |   |        |  
|Net gain on bond repurchase                                  |  |                         | 1,095   |   |      |   |        |      |  |   | 3,633   |  
|Gain on sale of biodefense assets, net                       |  |                         |        |   |      |   | 1,715   |      |  |   |        |  
|Interest income                                              |  |                         | 2,008   |   |      |   | 1,080   |      |  |   | 1,829   |  
|Interest expense                                             |  |                         | (11,304 | ) |      |   | (10,320 | )    |  |   | (8,438  | )
|                                                             |  |                         |         |   |      |   |         |      |  |   |         |  
|Income (loss) before income tax expense (benefit)            |  |                         | 75,900  |   |      |   | (19,534 | )    |  |   | (36,942 | )
|Income tax expense (benefit)                                 |  |                         | (37,805 | ) |      |   |        |      |  |   |        |  
|                                                             |  |                         |         |   |      |   |         |      |  |   |         |  
|Net income (loss)                                            |  | $                       | 113,705 |   |      | $ | (19,534 | )    |  | $ | (36,942 | )
|                                                             |  |                         |         |   |      |   |         |      |  |   |         |  
|Net income (loss) per share:                                 |  |                         |         |   |      |   |         |      |  |   |         |  
|Basic                                                        |  | $                       | 2.56    |   |      | $ | (0.73   | )    |  | $ | (1.43   | )
|Diluted                                                      |  | $                       | 2.02    |   |      | $ | (0.73   | )    |  | $ | (1.43   | )
|                                                             |  |                         |         |   |      |   |         |      |  |   |         |  
|Shares used in computing net income (loss) per share:        |  |                         |         |   |      |   |         |      |  |   |         |  
|Basic                                                        |  |                         | 44,334  |   |      |   | 26,578  |      |  |   | 25,916  |  
|Diluted                                                      |  |                         | 57,610  |   |      |   | 26,578  |      |  |   | 25,916  |  
|                                                             |  |                         |         |   |      |   |         |      |  |   |         |  



See accompanying notes
to consolidated finanical statements.



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##### Table of Contents

ViroPharma Incorporated

Consolidated Statements of Comprehensive Income (Loss)



|                                                                             |  |                         |         |   |      |   |         |      |  |   |         |  
|---------------------------------------------------------------------------- |  | ----------------------- | ------- | - | ---- | - | ------- | ---- |  | - | ------- | -
|                                                                             |  | Year ended December 31, |        
|                                                                             |  | 2005                    |         |   | 2004 |   |         | 2003 | 
|(in thousands)                                                               |  |                         |         |   |      |   |         |      |  |   |         |  
|Net income (loss)                                                            |  | $                       | 113,705 |   |      | $ | (19,534 | )    |  | $ | (36,942 | )
|                                                                             |  |                         |         |   |      |   |         |      |  |   |         |  
|Other comprehensive income (loss):                                           |  |                         |         |   |      |   |         |      |  |   |         |  
|Unrealized holding gains (losses) arising during period                      |  |                         | (497    | ) |      |   | 147     |      |  |   | (101    | )
|Reclassification adjustment for gains (losses) included in net income (loss) |  |                         |        |   |      |   | 101     |      |  |   | (41     | )
|Adjustment to unrealized loss on available for sale securities               |  |                         |        |   |      |   |        |      |  |   | 2,127   |  
|                                                                             |  |                         |         |   |      |   |         |      |  |   |         |  
|Unrealized gains (losses) on available for sale securities                   |  |                         | (497    | ) |      |   | 248     |      |  |   | 1,985   |  
|                                                                             |  |                         |         |   |      |   |         |      |  |   |         |  
|Comprehensive income (loss)                                                  |  | $                       | 113,208 |   |      | $ | (19,286 | )    |  | $ | (34,957 | )
|                                                                             |  |                         |         |   |      |   |         |      |  |   |         |  









See accompanying notes to consolidated financial statements.



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##### Table of Contents

ViroPharma Incorporated

Consolidated Statements of Stockholders Equity (Deficit)



|                                                                        |  |                 |  |              |   |                          |        |        |              |     |  |                                            |         |   |                    |   |      |                                   |  |   |        |   |  |   |          |   |  |   |         |  
|----------------------------------------------------------------------- |  | --------------- |  | ------------ | - | ------------------------ | ------ | ------ | ------------ | --- |  | ------------------------------------------ | ------- | - | ------------------ | - | ---- | --------------------------------- |  | - | ------ | - |  | - | -------- | - |  | - | ------- | -
|                                                                        |  | Preferred stock |  | Common stock |   | Additionalpaid-incapital |        |        | DeferredComp |     |  | Accumulatedothercomprehensiveincome (loss) |         |   | AccumulatedDeficit |   |      | Totalstockholdersequity(deficit) | 
|(in thousands)                                                          |  | Numberof shares |  | Amount       |   | Numberof shares          |        | Amount |              |     |  |                                            |        
|Balance, December 31, 2002                                              |  |                |  | $            |  |                          | 25,933 |        | $            | 52  |  | $                                          | 248,783 |   |                    | $ | (435 | )                                 |  | $ | (2,087 | ) |  | $ | (218,502 | ) |  | $ | 27,811  |  
|Issuance of common stock for note and accrued interest reduction        |  |                |  |              |  |                          | 473    |        |              | 1   |  |                                            | 1,173   |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 1,174   |  
|Employee stock purchase plan                                            |  |                |  |              |  |                          | 49     |        |              |    |  |                                            | 80      |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 80      |  
|Exercise of common stock options                                        |  |                |  |              |  |                          | 8      |        |              |    |  |                                            | 3       |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 3       |  
|Issuance of stock options to non-employees                              |  |                |  |              |  |                          |       |        |              |    |  |                                            | 281     |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 281     |  
|Amortization of deferred compensation                                   |  |                |  |              |  |                          |       |        |              |    |  |                                            |        |   |                    |   | 225  |                                   |  |   |       |   |  |   |         |   |  |   | 225     |  
|Unrealized loss on available for sale securities                        |  |                |  |              |  |                          |       |        |              |    |  |                                            |        |   |                    |   |     |                                   |  |   | (141   | ) |  |   |         |   |  |   | (141    | )
|Adjustment to unrealized loss on available for sale securities          |  |                |  |              |  |                          |       |        |              |    |  |                                            |        |   |                    |   |     |                                   |  |   | 2,127  |   |  |   | (2,127   | ) |  |   |        |  
|Net loss                                                                |  |                |  |              |  |                          |       |        |              |    |  |                                            |        |   |                    |   |     |                                   |  |   |       |   |  |   | (36,942  | ) |  |   | (36,942 | )
|                                                                        |  |                 |  |              |   |                          |        |        |              |     |  |                                            |         |   |                    |   |      |                                   |  |   |        |   |  |   |          |   |  |   |         |  
|Balance, December 31, 2003                                              |  |                |  | $            |  |                          | 26,463 |        | $            | 53  |  | $                                          | 250,320 |   |                    | $ | (210 | )                                 |  | $ | (101   | ) |  | $ | (257,571 | ) |  | $ | (7,509  | )
|Employee stock purchase plan                                            |  |                |  |              |  |                          | 16     |        |              |    |  |                                            | 26      |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 26      |  
|Exercise of common stock options                                        |  |                |  |              |  |                          | 279    |        |              | 1   |  |                                            | 252     |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 253     |  
|Stock option accelerations                                              |  |                |  |              |  |                          |       |        |              |    |  |                                            | 178     |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 178     |  
|Amortization of deferred compensation                                   |  |                |  |              |  |                          |       |        |              |    |  |                                            |        |   |                    |   | 200  |                                   |  |   |       |   |  |   |         |   |  |   | 200     |  
|Unrealized gain on available for sale securities                        |  |                |  |              |  |                          |       |        |              |    |  |                                            |        |   |                    |   |     |                                   |  |   | 248    |   |  |   |         |   |  |   | 248     |  
|Net income                                                              |  |                |  |              |  |                          |       |        |              |    |  |                                            |        |   |                    |   |     |                                   |  |   |       |   |  |   | (19,534  | ) |  |   | (19,534 | )
|                                                                        |  |                 |  |              |   |                          |        |        |              |     |  |                                            |         |   |                    |   |      |                                   |  |   |        |   |  |   |          |   |  |   |         |  
|Balance, December 31, 2004                                              |  |                |  | $            |  |                          | 26,758 |        | $            | 54  |  | $                                          | 250,776 |   |                    | $ | (10  | )                                 |  | $ | 147    |   |  | $ | (277,105 | ) |  | $ | (26,138 | )
|Issuance of common stock, net of issuance costs                         |  |                |  |              |  |                          | 10,350 |        |              | 21  |  |                                            | 163,478 |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 163,499 |  
|Shares issued from senior convertible notes conversions                 |  |                |  |              |  |                          | 30,000 |        |              | 59  |  |                                            | 74,941  |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 75,000  |  
|Shares issued from senior convertible notes make-whole payments         |  |                |  |              |  |                          | 899    |        |              | 2   |  |                                            | 5,647   |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 5,649   |  
|Beneficial conversion feature on senior convertible notes conversions   |  |                |  |              |  |                          |       |        |              |    |  |                                            | 1,489   |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 1,489   |  
|Employee stock purchase plan                                            |  |                |  |              |  |                          | 16     |        |              |    |  |                                            | 74      |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 74      |  
|Exercise of common stock options                                        |  |                |  |              |  |                          | 541    |        |              | 1   |  |                                            | 1,484   |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 1,485   |  
|Write-off of costs related to senior convertible notes conversions      |  |                |  |              |  |                          |       |        |              |    |  |                                            | (11,219 | ) |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | (11,219 | )
|Write-off of accrued interest from senior convertible notes conversions |  |                |  |              |  |                          |       |        |              |    |  |                                            | 766     |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 766     |  
|Unrealized loss on available for sale securities                        |  |                |  |              |  |                          |       |        |              |    |  |                                            |        |   |                    |   |     |                                   |  |   | (497   | ) |  |   |         |   |  |   | (497    | )
|Amortization of deferred compensation                                   |  |                |  |              |  |                          |       |        |              |    |  |                                            |        |   |                    |   | 7    |                                   |  |   |       |   |  |   |         |   |  |   | 7       |  
|Stock option tax benefits                                               |  |                |  |              |  |                          |       |        |              |    |  |                                            | 3,157   |   |                    |   |     |                                   |  |   |       |   |  |   |         |   |  |   | 3,157   |  
|Net income                                                              |  |                |  |              |  |                          |       |        |              |    |  |                                            |        |   |                    |   |     |                                   |  |   |       |   |  |   | 113,705  |   |  |   | 113,705 |  
|                                                                        |  |                 |  |              |   |                          |        |        |              |     |  |                                            |         |   |                    |   |      |                                   |  |   |        |   |  |   |          |   |  |   |         |  
|Balance, December 31, 2005                                              |  |                |  | $            |  |                          | 68,564 |        | $            | 137 |  | $                                          | 490,593 |   |                    | $ | (3   | )                                 |  | $ | (350   | ) |  | $ | (163,400 | ) |  | $ | 326,977 |  
|                                                                        |  |                 |  |              |   |                          |        |        |              |     |  |                                            |         |   |                    |   |      |                                   |  |   |        |   |  |   |          |   |  |   |         |  



See accompanying notes
to consolidated financial statements.



73



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##### Table of Contents

ViroPharma Incorporated

Consolidated Statements of Cash Flows



|                                                                                                   |  |                         |          |   |      |   |          |      |  |   |          |  
|-------------------------------------------------------------------------------------------------- |  | ----------------------- | -------- | - | ---- | - | -------- | ---- |  | - | -------- | -
|                                                                                                   |  | Year ended December 31, |         
|(in thousands)                                                                                     |  | 2005                    |          |   | 2004 |   |          | 2003 | 
|Cash flows from operating activities:                                                              |  |                         |          |   |      |   |          |      |  |   |          |  
|Net income (loss)                                                                                  |  | $                       | 113,705  |   |      | $ | (19,534  | )    |  | $ | (36,942  | )
|Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: |  |                         |          |   |      |   |          |      |  |   |          |  
|Gain on sale of biodefense assets                                                                  |  |                         |         |   |      |   | (1,715   | )    |  |   |         |  
|Gain on bond repurchase                                                                            |  |                         | (1,346   | ) |      |   |         |      |  |   | (3,725   | )
|Write-off of deferred financing costs on note repurchase                                           |  |                         | 251      |   |      |   |         |      |  |   | 92       |  
|Non-cash loss on derivative liability                                                              |  |                         | 4,044    |   |      |   |         |      |  |   |         |  
|Non-cash settlement of interest payable related to note reduction                                  |  |                         |         |   |      |   |         |      |  |   | 24       |  
|Non-cash charge for lease costs                                                                    |  |                         |         |   |      |   |         |      |  |   | 1,650    |  
|Non-cash write-off of fixed assets                                                                 |  |                         |         |   |      |   | 4,782    |      |  |   |         |  
|Non-cash compensation expense                                                                      |  |                         | 7        |   |      |   | 378      |      |  |   | 507      |  
|Non-cash interest expense                                                                          |  |                         | 3,865    |   |      |   | 1,369    |      |  |   | 612      |  
|Deferred tax provision                                                                             |  |                         | (47,755  | ) |      |   |         |      |  |   |         |  
|Stock option tax benefit                                                                           |  |                         | 2,393    |   |      |   |         |      |  |   |         |  
|Depreciation and amortization expense                                                              |  |                         | 5,537    |   |      |   | 1,176    |      |  |   | 2,287    |  
|Changes in assets and liabilities:                                                                 |  |                         |          |   |      |   |          |      |  |   |          |  
|Accounts receivable                                                                                |  |                         | (5,717   | ) |      |   | (9,170   | )    |  |   |         |  
|Inventory                                                                                          |  |                         | (9,974   | ) |      |   |         |      |  |   |         |  
|Income taxes receivable                                                                            |  |                         | (1,977   | ) |      |   |         |      |  |   |         |  
|Due to partners                                                                                    |  |                         | (391     | ) |      |   | 412      |      |  |   | (694     | )
|Other current assets                                                                               |  |                         | (282     | ) |      |   | 1,464    |      |  |   | 354      |  
|Other assets                                                                                       |  |                         | 45       |   |      |   |         |      |  |   | 49       |  
|Accounts payable                                                                                   |  |                         | 8,465    |   |      |   | 141      |      |  |   | (330     | )
|Accrued expenses and other current liabilities                                                     |  |                         | 8,055    |   |      |   | 3,933    |      |  |   | (4       | )
|Deferred revenue                                                                                   |  |                         | (563     | ) |      |   | (3,074   | )    |  |   | 1,125    |  
|Derivative liability payments                                                                      |  |                         | (6,823   | ) |      |   |         |      |  |   |         |  
|Other liabilities                                                                                  |  |                         | (36      | ) |      |   | (373     | )    |  |   | 794      |  
|                                                                                                   |  |                         |          |   |      |   |          |      |  |   |          |  
|Net cash provided by (used in) operating activities                                                |  |                         | 71,503   |   |      |   | (20,211  | )    |  |   | (34,201  | )
|                                                                                                   |  |                         |          |   |      |   |          |      |  |   |          |  
|                                                                                                   |  |                         |         
|Cash flows from investing activities:                                                              |  |                         |          |   |      |   |          |      |  |   |          |  
|Purchase of Vancocin assets and starting material inventory                                        |  |                         | (10,490  | ) |      |   | (118,031 | )    |  |   |         |  
|Purchase of equipment and leasehold improvements                                                   |  |                         | (431     | ) |      |   | (1,005   | )    |  |   | (984     | )
|Proceeds from sale of equipment                                                                    |  |                         |         |   |      |   | 1,407    |      |  |   |         |  
|Proceeds from sale of biodefense assets                                                            |  |                         |         |   |      |   | 700      |      |  |   |         |  
|Purchase of restricted investment                                                                  |  |                         |         |   |      |   | (10,000  | )    |  |   |         |  
|Maturities of restricted investments                                                               |  |                         | 9,033    |   |      |   | 967      |      |  |   |         |  
|Purchases of short-term investments                                                                |  |                         | (292,696 | ) |      |   | (208,430 | )    |  |   | (141,812 | )
|Maturities of short-term investments                                                               |  |                         | 303,165  |   |      |   | 305,688  |      |  |   | 176,138  |  
|                                                                                                   |  |                         |          |   |      |   |          |      |  |   |          |  
|Net cash provided by (used in) investing activities                                                |  |                         | 8,581    |   |      |   | (28,704  | )    |  |   | 33,342   |  
|                                                                                                   |  |                         |          |   |      |   |          |      |  |   |          |  
|Cash flows from financing activities:                                                              |  |                         |          |   |      |   |          |      |  |   |          |  
|Net proceeds from issuance of common stock                                                         |  |                         | 165,058  |   |      |   | 279      |      |  |   | 83       |  
|Gross proceeds from issuance of senior convertible notes                                           |  |                         |         |   |      |   | 62,500   |      |  |   |         |  
|Gross proceeds from the issuance of senior notes                                                   |  |                         | 12,500   |   |      |   |         |      |  |   |         |  
|Issuance costs related to senior notes                                                             |  |                         | (806     | ) |      |   | (3,832   | )    |  |   |         |  
|Repurchase of subordinated convertible notes                                                       |  |                         | (47,634  | ) |      |   |         |      |  |   | (2,125   | )
|Payment of loans payable                                                                           |  |                         |         |   |      |   | (8       | )    |  |   | (117     | )
|                                                                                                   |  |                         |          |   |      |   |          |      |  |   |          |  
|Net cash provided by (used in) financing activities                                                |  |                         | 129,118  |   |      |   | 58,939   |      |  |   | (2,159   | )
|                                                                                                   |  |                         |          |   |      |   |          |      |  |   |          |  
|                                                                                                   |  |                         |         
|Net increase (decrease) in cash and cash equivalents                                               |  |                         | 209,202  |   |      |   | 10,024   |      |  |   | (3,018   | )
|Cash and cash equivalents at beginning of year                                                     |  |                         | 22,993   |   |      |   | 12,969   |      |  |   | 15,987   |  
|                                                                                                   |  |                         |          |   |      |   |          |      |  |   |          |  
|Cash and cash equivalents at end of year                                                           |  | $                       | 232,195  |   |      | $ | 22,993   |      |  | $ | 12,969   |  
|                                                                                                   |  |                         |          |   |      |   |          |      |  |   |          |  



See accompanying notes
to consolidated financial statements.





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ViroPharma Incorporated

Notes to the Consolidated Financial Statements



1.    Organization and Business Activities



ViroPharma Incorporated and subsidiaries (ViroPharma or
the Company) is a biopharmaceutical company dedicated to the development and commercialization of products that address serious diseases. The Company has a core expertise in the area of infectious diseases and is committed to focusing
its commercialization and development programs on products used by physician specialists or in hospital settings. The Company intends to grow through sales of it marketed product, Vancocin, and continued development of its product pipeline and
potential acquisition of products or companies.



ViroPharma has
one marketed product and multiple product candidates in clinical development. The Company markets and sells Vancocin Capsules, HCl, the oral capsule formulation of vancomycin hydrochloride, in the U.S. and its territories. Vancocin is a potent
antibiotic approved by the U.S. Food and Drug Administration, or FDA, to treat antibiotic-associated pseudomembranous colitis caused by Clostridium difficile, or C. difficile, and enterocolitis caused by Staphylococcus aureus,
including methicillin-resistant strains.



ViroPharma is
developing maribavir for the treatment of cytomegalovirus, or CMV, infection and HCV-796 for the treatment of hepatitis C virus, or HCV, infection. The Company has licensed the U.S. and Canadian rights for a third product candidate, an intranasal
formulation of pleconaril, to Schering-Plough for the treatment of picornavirus infections.



2.    Basis of Accounting and Summary of Significant Accounting Policies



Principles of Consolidation



The consolidated financial statements include the accounts of ViroPharma and its wholly-owned subsidiaries. All intercompany accounts and transactions
have been eliminated in consolidation.



Cash and cash equivalents



The Company considers all highly liquid investments with
an original maturity of three months or less when purchased to be cash equivalents. All cash and cash equivalents are held in United States (U.S.) financial institutions.



Short-term investments



During 2004 and 2005, short-term investments has consisted primarily of debt securities backed by the U.S. government and commercial paper. The
Companys entire short-term investment portfolio is classified as available-for-sale and is stated at fair value as determined by quoted market values. All short-term investments, including securities with maturities in excess of one year, are
classified as current, as management can sell them any time at their option and are intended to meet the ongoing liquidity needs of the Company. Net unrealized holding gains and losses are included in accumulated other comprehensive income (loss).
For purposes of determining gross realized gains and losses, the cost of short-term investments sold is based upon specific identification. The investments are reviewed on a periodic basis for other-than-temporary impairments. The Company has not
experienced any significant realized gains or losses on its investments in the years ended December 31, 2005, 2004 and 2003. (see Note 3)



During the second quarter of 2003, the Company discovered that it had been accounting for the discounts and premiums associated with its short-term
investments incorrectly. The amortization of these discounts and premiums should have been recorded ratably over the holding period for each investment to interest income. In financial statements prior to the second quarter of 2003, the Company
reported these amounts as a change in



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



accumulated other comprehensive income (loss), a component of stockholders deficit, in the consolidated balance sheet. Due to the lack of materiality,
the cumulative net effect of the activity of approximately $2.1 million was relieved from accumulated other comprehensive income (loss) and charged directly to accumulated deficit in the consolidated balance sheet in 2003. The effect of this charge
on the net loss for the year ended December 31, 2003 was immaterial.



Concentration of credit risk



The Company
invests its excess cash and short-term investments in accordance with a policy objective that seeks to ensure both liquidity and safety of principal. The policy limits investments to certain types of instruments issued by the U.S. government and
institutions with strong investment grade credit ratings and places restrictions in their terms and concentrations by type and issuer to reduce the Companys credit risk.



The Company has an exposure to credit risk in its trade accounts receivable from sales of Vancocin. Vancocin is distributed
through wholesalers that sell the product to pharmacies and hospitals. Three wholesalers represent approximately 94% of our trade accounts receivable at December 31, 2005 and 89% of our 2005 net product sales.



Accounts Receivable



Accounts receivable are recorded at the invoiced amount, net of related cash discounts, and do not bear interest. The
allowance for doubtful accounts is the Companys best estimate of the amount of probable credit losses in the Companys existing accounts receivable. The Company determines the allowance based on specific review of its accounts receivable.
At December 31, 2005, there is no allowance for doubtful accounts. The Company does not have any off-balance sheet exposure related to its customers.



Inventories



Inventories are stated at the lower of cost, using the first-in, first-out method, or market. At December 31, 2005 inventory consists of finished
goods and certain starting materials required to produce inventory of Vancocin. Inventory at December 31, 2004 consists solely of starting materials (see Note 4). On the consolidated statement of cash flows, the sale of inventory is
included in operating activities.



Equipment and leasehold improvements



Equipment and leasehold improvements are recorded at
cost. Depreciation and amortization are computed on a straight-line basis over the useful lives of the assets or the lease term, which ever is lower, ranging from three to fifteen years.



The Company leases certain of its equipment and facilities under operating leases. Operating lease payments are charged to
operations over the related period that such leased assets are utilized in service. Expenditures for repairs and maintenance are expensed as incurred.



Intangible Assets



Intangible assets, net of accumulated amortization, includes the allocation of the cost to acquire the rights to the oral formulation of Vancocin, as well
as rights to certain vancomycin related Vancocin products, from Eli Lilly and Company (Lilly) (see Note 6). The Company based its intangible assets valuation and related estimated useful life on third party evaluations of the
assets. Each intangible asset acquired as part of the



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



Vancocin acquisition is being amortized on a straight-line basis over the estimated useful life of 25 years. The Company estimated the useful life of the
assets by considering remaining patent life, if any, competition by products prescribed for the same indication, the likelihood and estimated future entry of non-generic and generic competition with the same or similar indication and other related
factors. The factors that drive the estimate of the life are often uncertain and are reviewed on a periodic basis or when events occur that warrant review.



Impairment or Disposal of Long-Lived Assets



The Company assesses the recoverability of long-lived assets for which an indicator of impairment exists, as necessary. Specifically, the Company
determines if a long-lived asset or asset group is impaired by comparing the carrying value of these assets to their estimated undiscounted future operating cash flows. If an impairment is indicated, a charge is recognized for the difference between
the assets carrying value and fair value.



Revenue recognition



Revenue is recognized when all four of the following
criteria are met (1) the Company has persuasive evidence of an arrangement exists, (2) the price is fixed and determinable, (3) title has passed, and (4) collection is reasonably assured. The companys credit and exchange
policy includes provisions for return of its product when it (1) has expired, or (2) was damaged in shipment.



Product revenue is recorded upon delivery to the wholesaler, when title has passed. Product demand from wholesalers during a given period may not
correlate with prescription demand for the product in that period. As a result, the Company periodically estimates and evaluates the wholesalers inventory position. If the Company believes these levels are too high and there may be excess
inventory in the channel for this product, based on prescription demand, it may not process wholesaler orders until these levels are reduced or it may defer recognition of revenue on product that has been delivered. During 2005 and 2004, the Company
did not defer any product sales.



Contract revenues are earned
and recognized according to the provisions of each agreement. Contract milestone payments related to the achievement of substantive steps or regulatory events in the development process are recognized as revenues upon the completion of the milestone
event or requirement. Payments, if any, received in advance of performance under a contract are deferred and recognized as revenue when earned. Up-front licensing fees where the Company has continuing involvement are deferred and amortized over the
estimated performance period. Revenue from government grants is recognized as the related performance to which they are related occurs.



Sales Allowances



The Company records appropriate sales allowances upon the recognition of product revenue. The Companys return policy is limited to damaged or
expired product. The return allowance is determined based on analysis of the historical rate of returns associated with Vancocin, which is then applied to sales, and is analyzed considering estimated wholesaler inventory and prescriptions. The
chargeback allowance is determined based on analysis of the historical experience of government agencies market share and governmental contractual prices.



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



Customers



The Companys net product sales are solely related to Vancocin. The Companys customers are wholesalers who then distribute the product to
pharmacies and hospitals. Three wholesalers represent approximately 86% of 2005 consolidated total revenue, as detailed below:



|           |  |                              |  
|---------- |  | ---------------------------- | -
|           |  | Percentage of total revenues |  
|Customer A |  | 40                           | %
|Customer B |  | 29                           | %
|Customer C |  | 17                           | %



During 2004 and a
portion of the quarter ended March 31, 2005, Vancocin was sold under our transition services agreement with Lilly, who represented our only customer during the transition period. The transition agreement was terminated in January 2005, and upon
the termination, we began selling directly to wholesalers. In 2003, the Company did not have product sales of Vancocin.



Research and development expenses



Research and product development costs are expensed as incurred. Reimbursements of research and development costs under cost sharing collaborations are
recorded as a reduction of research and development expenses. Research and development costs include costs for discovery research, pre-clinical and clinical trials, manufacture of drug supply, supplies and acquired services, employee-related costs
and allocated and direct facility expenses.



Licensed technology



Costs incurred in obtaining the license rights to
technology in the research and development stage are expensed as incurred and in accordance with the specific contractual terms of such license agreements.



Accounting for income taxes



Income taxes are accounted for under the asset and liability method. Deferred tax assets and liabilities are recognized for the future tax consequences
attributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases and operating loss and tax credit carryforwards. Deferred tax assets and liabilities are measured using
enacted tax rates expected to apply to taxable income in the years in which those temporary difference are expected to be recovered or settled. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in operations in
the period that includes the enactment date. A valuation allowance is provided when it is more likely than not that some portion or all of a deferred tax asset will not be realized. The ultimate realization of deferred tax assets is dependent upon
the generation of future taxable income and the reversal of deferred tax liabilities during the period in which related temporary difference becomes deductible. (see Note 12)



Use of estimates



The preparation of the Companys consolidated financial statements in conformity with accounting principles generally accepted in the United States
of America requires management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. Actual results could differ from those estimates.



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



Stock-based compensation



The Company accounts for its stock option plans in accordance with the provisions of APB Opinion No. 25,
Accounting for Stock Issued to Employees, and related interpretations (APB 25). As such, compensation cost is measured on the date of grant as the excess, if any, of the current market price of the underlying common stock over the
exercise price of the option. Such compensation amounts are amortized over the respective vesting periods of the option grant. The Company adopted the disclosure provisions of SFAS No. 123, Accounting for Stock-Based Compensation,
as amended (SFAS No. 123), which permits entities to provide pro forma net income (loss) and pro forma income (loss) per share disclosures for employee stock option grants as if the fair-value based method defined in SFAS No. 123 had been
applied.



Compensation expense for options granted to
non-employees is determined in accordance with SFAS No. 123, and related interpretations, as the fair value of the consideration received or the fair value of the equity instruments issued, whichever is more reliably measured. Compensation
expense for options granted to non-employees is remeasured each period as the underlying options vest.



If the Company determined compensation cost for options granted based on their fair value at the grant date under SFAS No. 123, the Companys
net income (loss) and net income (loss) per share would have been impacted as indicated below. The amounts for 2005 are net of the related tax consequences. Option forfeitures are accounted for as they occurred and no amounts of compensation expense
have been capitalized into inventory or other assets, but instead are considered period expenses in the pro forma amounts.



|                                                                                                                                                        |  |      |         |   |      |   |         |      |  |   |         |  
|------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ---- | ------- | - | ---- | - | ------- | ---- |  | - | ------- | -
|(in thousands, except per share data)                                                                                                                   |  | 2005 |         |   | 2004 |   |         | 2003 | 
|Net income (loss):                                                                                                                                      |  |      |         |   |      |   |         |      |  |   |         |  
|As reported                                                                                                                                             |  | $    | 113,705 |   |      | $ | (19,534 | )    |  | $ | (36,942 | )
|Add: stock-based employee and directors compensation expense included in net income (loss)                                                              |  |      | 4       |   |      |   | 378     |      |  |   | 507     |  
|Deduct: total stock-based employee and directors compensation expense determined under the fair value-based method for all employee and
director awards |  |      | (1,418  | ) |      |   | (2,992  | )    |  |   | (8,143  | )
|                                                                                                                                                        |  |      |         |   |      |   |         |      |  |   |         |  
|Pro forma net income (loss)                                                                                                                             |  | $    | 112,291 |   |      | $ | (22,148 | )    |  |   | (44,578 | )
|                                                                                                                                                        |  |      |         |   |      |   |         |      |  |   |         |  
|Net income (loss) per sharebasic                                                                                                                       |  |      |         |   |      |   |         |      |  |   |         |  
|As reported                                                                                                                                             |  | $    | 2.56    |   |      | $ | (0.73   | )    |  | $ | (1.43   | )
|                                                                                                                                                        |  |      |         |   |      |   |         |      |  |   |         |  
|Pro forma under SFAS No. 123                                                                                                                            |  |      | 2.53    |   |      |   | (0.83   | )    |  |   | (1.72   | )
|                                                                                                                                                        |  |      |         |   |      |   |         |      |  |   |         |  
|Net income (loss) per sharediluted                                                                                                                     |  |      |         |   |      |   |         |      |  |   |         |  
|As reported                                                                                                                                             |  | $    | 2.02    |   |      | $ | (0.73   | )    |  | $ | (1.43   | )
|                                                                                                                                                        |  |      |         |   |      |   |         |      |  |   |         |  
|Pro forma under SFAS No. 123                                                                                                                            |  | $    | 2.00    |   |      | $ | (0.83   | )    |  | $ | (1.72   | )
|                                                                                                                                                        |  |      |         |   |      |   |         |      |  |   |         |  



Financial Instruments



The Companys short-term investments are carried at
fair value. Cash and cash equivalents, restricted cash equivalents, accounts receivable, income taxes receivable, due to partners, accounts payable, accrued expenses and other current liabilities are financial instruments that are carried at cost
which approximate fair value due to their short-term nature. At December 31, 2004, the Companys Senior Notes of $62.5 million were carried at cost, which approximated fair value due to their short-term nature. The Companys
Subordinated Convertible Notes have a fair value of $79.3 million and $115.1 million at December 31, 2005 and 2004, respectively.



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



Earnings (loss) / per share



Basic earnings (loss) per share (EPS) is calculated by dividing net income (loss) by the weighted average shares
of common stock outstanding during the period. Diluted EPS reflects the potential dilution of securities that could share in the earnings (loss), including the effect of dilution to net income of convertible securities, stock options and warrants.
(See Note 13)



Segment information



The Company is managed and operated as one business. The entire business is
managed by a single management team that reports to the chief executive officer. The Company does not operate separate lines of business or separate business entities with respect to any of its products or product candidates and all of its product
sales are within the U.S. Accordingly, the Company does not prepare discrete financial information with respect to separate product areas or by location and does not have separately reportable segments as defined by SFAS No. 131,
Disclosures about Segments of an Enterprise and Related Information.



Comprehensive income (loss)



SFAS
No. 130, Reporting Comprehensive Income, establishes standards for reporting and presentation of comprehensive income (loss) and its components in a full set of financial statements. Comprehensive income (loss) consists of net
income (loss) and net unrealized gains (losses) on availablefor-sale securities and is presented in the consolidated statements of comprehensive income (loss). SFAS No. 130 requires only additional disclosures in the financial statements;
it does not affect the Companys financial position or results of operations.



Exit or Disposal Activities



SFAS
No. 146, Accounting for Costs Associated with Exit or Disposal Activities, addresses financial accounting and reporting for costs associated with exit or disposal activities. This statement requires a liability for a cost associated
with an exit or disposal activity be recognized and measured initially at fair value only when the liability is incurred. It does not apply to costs associated with an entity newly acquired in a business combination or with a disposal activity
covered by SFAS No. 144.



Reclassification



Certain prior years amounts have been reclassified to conform to the current
year presentation.



New Accounting Standards



In November 2004, the FASB issued SFAS No. 151, Inventory Costs,
an Amendment of ARB No. 43, Chapter 4, Inventory Pricing, to clarify the accounting for abnormal amounts of idle facility expense, freight, handling costs and wasted material. This statement requires those items be recognized
as current-period charges. We have early adopted this standard as of January 1, 2005, as permitted. Adoption of this statement had no impact on the consolidated financial statements.



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



3.    Short-Term Investments



Short-term investments consist of fixed income securities with original
maturities of greater than three months at the date of purchase and our marketable securities investment in SIGA (see Note 9). At December 31, 2005 and 2004, all of the short-term investments were classified as available for sale investments.



The following summarizes the available for sale investments at
December 31, 2005 and 2004:



|                                           |  |      |        |                      |   |                       |  |            |     |  |   |       
|------------------------------------------ |  | ---- | ------ | -------------------- | - | --------------------- |  | ---------- | --- |  | - | ------
|(in thousands)                             |  | Cost |        | Grossunrealizedgains |   | Grossunrealizedlosses |  | Fair value
|2005                                       |  |      |        |                      |   |                       |  |            |     |  |   |       
|Certificates of deposit                    |  | $    | 553    |                      | $ |                      |  | $          |    |  | $ | 553   
|Marketable equity securities               |  |      | 1,015  |                      |   |                      |  |            | 350 |  |   | 665   
|                                           |  |      |        |                      |   |                       |  |            |     |  |   |       
|                                           |  | $    | 1,568  |                      | $ |                      |  | $          | 350 |  | $ | 1,218 
|                                           |  |      |        |                      |   |                       |  |            |     |  |   |       
|                                           |  |      |        |                     
|Maturities of investments were as follows: |  |      |        |                      |   |                       |  |            |     |  |   |       
|Less than 1 year                           |  | $    | 553    |                      | $ |                      |  | $          |    |  | $ | 553   
|                                           |  |      |        |                      |   |                       |  |            |     |  |   |       
|2004                                       |  |      |        |                      |   |                       |  |            |     |  |   |       
|Certificates of deposit                    |  | $    | 11,022 |                      | $ |                      |  | $          |    |  | $ | 11,022
|Marketable equity securities               |  |      | 1,015  |                      |   | 147                   |  |            |    |  |   | 1,162 
|                                           |  |      |        |                      |   |                       |  |            |     |  |   |       
|                                           |  | $    | 12,037 |                      | $ | 147                   |  | $          |    |  | $ | 12,184
|                                           |  |      |        |                      |   |                       |  |            |     |  |   |       



The unrealized loss,
which has been experienced for less than twelve months as of December 31, 2005, has been deemed not to be other-than-temporary due to announcements by SIGA on developments in its clinical trials and an equity offering, which provide reassurance
as to the near-term prospects of SIGA. The Company has the ability and intent to hold the investment for a period of time sufficient to recover the fair value of the investment.



4.    Inventory



The following represents the components of inventory at December 31, 2005 and 2004:



|               |  |                  |        |                  |   |      
|-------------- |  | ---------------- | ------ | ---------------- | - | -----
|(in thousands) |  | December 31,2005 |        | December 31,2004
|Raw Materials  |  | $                | 2,108  |                  | $ | 1,022
|Finished Goods |  |                  | 8,888  |                  |   |     
|               |  |                  |        |                  |   |      
|Total          |  | $                | 10,996 |                  | $ | 1,022
|               |  |                  |        |                  |   |      



The raw material
increase related primarily to the purchase of API (active pharmaceutical ingredient) for use by our third party manufacturer upon completion of the transition from Lilly.



In 2004, the Company did not own any finished goods. During 2005, in connection with the manufacturing agreements with
Lilly, the Company purchased finished goods from Lilly in order to meet anticipated demand. At December 31, 2005, the Company had $8.9 million of costs related directly to finished goods inventory. Included in the $8.9 million is $4.4 million
related to additional costs due to an amended manufacturing agreement with Lilly, which, among other things, increased the amount of Vancocin that Lilly supplied to the Company during 2005. The amendment stated that if Lilly supplied the full amount
of increased product volume,



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



the Company would pay Lilly up to $4.5 million in addition to the original contract price for those additional units. Lilly supplied the agreed upon
increased product volume in December 2005, $0.1 million of which was sold in 2005. Therefore, the finished goods inventory includes $4.4 million of additional cost, which will increase cost of sales as these specific units are sold. At
December 31, 2005, accrued expenses includes $4.0 million related to this amended manufacturing agreement, as $0.5 million of the additional cost was paid in 2005.



5.    Equipment and Leasehold Improvements



Equipment and leasehold improvements consists of the following at December 31, 2005 and 2004:



|                                                |  |      |       |      |   |      
|----------------------------------------------- |  | ---- | ----- | ---- | - | -----
|(in thousands)                                  |  | 2005 |       | 2004
|Computers and equipment                         |  | $    | 1,560 |      | $ | 1,123
|Leasehold improvements                          |  |      | 1,326 |      |   | 1,332
|                                                |  |      |       |      |   |      
|                                                |  |      | 2,886 |      |   | 2,455
|Less: accumulated depreciation and amortization |  |      | 1,331 |      |   | 952  
|                                                |  |      |       |      |   |      
|Equipment and leasehold improvements, net       |  | $    | 1,555 |      | $ | 1,503
|                                                |  |      |       |      |   |      



The useful life for
computers and equipment is three to five years.



The useful
life for leasehold improvements is the shorter of 15 years or the remaining life of the lease. The 15 years represents the term of the lease, which expires in 2017, as it is not reasonably assured that the lease extensions will be exercised.



6.    Intangible Assets



The following represents the balance of the intangible assets at
December 31, 2005:



|                       |  |                       |         |                         |   |                     |  |   |        
|---------------------- |  | --------------------- | ------- | ----------------------- | - | ------------------- |  | - | -------
|(in thousands)         |  | GrossIntangibleAssets |         | AccumulatedAmortization |   | NetIntangibleAssets
|Trademarks             |  | $                     | 11,412  |                         | $ | 520                 |  | $ | 10,892 
|Know-how               |  |                       | 79,880  |                         |   | 3,639               |  |   | 76,241 
|Customer relationships |  |                       | 36,207  |                         |   | 1,649               |  |   | 34,558 
|                       |  |                       |         |                         |   |                     |  |   |        
|Total                  |  | $                     | 127,499 |                         | $ | 5,808               |  | $ | 121,691
|                       |  |                       |         |                         |   |                     |  |   |        



The following
represents the balance of the intangible assets at December 31, 2004:



|                       |  |                       |         |                         |   |                     |  |   |        
|---------------------- |  | --------------------- | ------- | ----------------------- | - | ------------------- |  | - | -------
|(in thousands)         |  | GrossIntangibleAssets |         | AccumulatedAmortization |   | NetIntangibleAssets
|Trademarks             |  | $                     | 10,473  |                         | $ | 58                  |  | $ | 10,415 
|Know-how               |  |                       | 73,308  |                         |   | 407                 |  |   | 72,901 
|Customer relationships |  |                       | 33,228  |                         |   | 185                 |  |   | 33,043 
|                       |  |                       |         |                         |   |                     |  |   |        
|Total                  |  | $                     | 117,009 |                         | $ | 650                 |  | $ | 116,359
|                       |  |                       |         |                         |   |                     |  |   |        



The gross intangible
asset increase of $10.5 million in the twelve month period ending December 31, 2005, relates to the Companys commercial product, Vancocin. This increase was due to additional purchase price consideration owed to Lilly when net sales of
Vancocin were within a pre-specified range. This obligation is



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



based on net sales of Vancocin within the calendar year, is paid quarterly and is due each year through 2011, the amount of which is determined by annual net
sales of Vancocin. The range of net sales of Vancocin for 2005 on which the payments were calculated was $44 million to $65 million in net sales of Vancocin, of which 50% was due to Lilly.



The Company has accounted for these additional payments as additional
purchase price in accordance with SFAS No. 141, Business Combinations. The additional purchase price consideration was recorded as a $10.5 million increase to the intangible assets of Vancocin, was allocated over the asset
classifications described above and will be amortized over the remaining estimated useful life of the intangible assets, which is estimated to be 23.8 years as of December 31, 2005. In addition, at the time of recording the additional
intangible assets, the Company recorded a cumulative adjustment of approximately $0.3 million to accumulated intangible amortization, in addition to ordinary amortization expense during the year ended December 31, 2005, in order to reflect
amortization as if the additional purchase price had been paid in November 2004.



The Company will pay additional amounts based on annual net sales of Vancocin as set forth below:



|                  |  |                                                
|----------------- |  | -----------------------------------------------
|2006              |  | 35% payment on net sales between $46-65 million
|2007              |  | 35% payment on net sales between $48-65 million
|2008 through 2011 |  | 35% payment on net sales between $45-65 million



No additional payments
are due to Lilly on net sales of Vancocin below or above the net sales levels reflected in the above table. We will account for the future additional payments as contingent consideration and record an adjustment to the carrying amount of the related
intangible assets and a cumulative adjustment to the intangible amortization upon achievement of the related sales milestones. Assuming the maximum threshold is met at the end of each year, the cumulative amortization adjustment would be $0.6
million, $0.7 million and $1.2 million in the years ended December 31, 2006, 2007 and 2008, respectively.



Amortization expense for the years ended December 31, 2005 and 2004 was $5.2 million and $0.7 million. The estimated aggregated amortization expense
for each of the next five years will be approximately $5.1 million, excluding any future increases related to additional purchase price consideration that may be payable to Lilly.



7.    Accrued expenses and other current liabilities



Accrued expenses and other current liabilities consist of the following at
December 31, 2005 and 2004:



|                                                 |  |              |        |      |   |       
|------------------------------------------------ |  | ------------ | ------ | ---- | - | ------
|                                                 |  | December 31,
|(in thousands)                                   |  | 2005         |        | 2004
|Rebates and returns                              |  | $            | 7,680  |      | $ | 643   
|Payable to Lilly (see Note 4)                    |  |              | 4,000  |      |   | 1,716 
|Insurance payable                                |  |              | 2,040  |      |   | 923   
|Payroll, bonus and employee benefits liabilities |  |              | 1,854  |      |   | 1,289 
|Other current liabilities                        |  |              | 1,744  |      |   | 1,521 
|Interest payable                                 |  |              | 1,578  |      |   | 2,818 
|Clinical development and research liabilities    |  |              | 506    |      |   | 891   
|Lease exit costs                                 |  |              |       |      |   | 1,546 
|                                                 |  |              |        |      |   |       
|                                                 |  | $            | 19,402 |      | $ | 11,347
|                                                 |  |              |        |      |   |       



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



8.    Long-Term Debt



On December 31, 2005 and 2004, the Companys long-term indebtedness includes the following:



|                                                                               |  |              |        |      |   |        
|------------------------------------------------------------------------------ |  | ------------ | ------ | ---- | - | -------
|                                                                               |  | December 31,
|(in thousands)                                                                 |  | 2005         |        | 2004
|Subordinated Convertible Notes, 6% interest paid semi-annually, due March 2007 |  | $            | 78,920 |      | $ | 127,900
|Senior Notes, 10% interest paid monthly                                        |  |              |       |      |   | 62,500 
|Senior Convertible Notes, 6% interest paid semi-annually, due October 2009     |  |              |       |      |   |       
|                                                                               |  |              |        |      |   |        
|Subtotal                                                                       |  |              | 78,920 |      |   | 190,400
|Less current portion                                                           |  |              | 78,920 |      |   |       
|                                                                               |  |              |        |      |   |        
|Total long-term debt                                                           |  | $            |       |      | $ | 190,400
|                                                                               |  |              |        |      |   |        



The subordinated
convertible notes are reported as current since, as of December 31, 2005, it was the Companys intent to redeem these notes in the first quarter of 2006. On March 1, 2006, the Company redeemed the remaining $78.9 million principal
amount of subordinated convertible notes for $79.6 million. This eliminated the Companys long-term debt that was outstanding at December 31, 2005.



Subordinated Convertible Notes



The Company made a private offering of $180.0 million of 6% subordinated convertible notes due March 2007 (the subordinated convertible
notes), which closed on March 8, 2000. Gross proceeds from the issuance of the subordinated convertible notes were $180.0 million. Debt issuance costs of $5.7 million have been capitalized and are being amortized over the term of the
notes. The notes are convertible into shares of the Companys common stock at a price of $109.15 per share, subject to certain adjustments. The notes bear interest at a rate of 6% per annum, payable semi-annually in arrears, and can be
redeemed by the Company, at certain premiums over the principal amount, at any time. The notes are subordinated in right of payment to all senior indebtedness of the Company. The notes may be required to be repaid on the occurrence of certain
fundamental changes, as defined.



In September 2004, the
Companys Board authorized the Notes Repurchase Committee of the Board to approve the issuance of up to 5,000,000 shares of its common stock in exchange for the surrender of subordinated convertible notes from time to time. In 2005, the
Companys Board authorized the Notes Repurchase Committee of the Board to approve the expenditure of up to $48.0 million to purchase the subordinated convertible notes from time to time, of which the Company has expended $47.6 million to
purchase $49.0 million of subordinated convertible notes as of December 31, 2005. The Company has recorded a $1.1 million gain, net of the write off of deferred finance costs, in connection with the 2005 repurchases.



From the issuance date of the subordinated convertible notes through
December 31, 2005, the Company has reduced the outstanding principal amount of its subordinated convertible notes by $101.1 million, including purchasing for cash an aggregate of $99.1 million in principal amount of its subordinated convertible
notes for approximately $66.2 million and entering into agreements with a third party under which it issued 473,054 shares of its common stock in exchange for the surrender of $2.0 million of face amount of its subordinated convertible notes held by
such third party. The shares issued in this transaction had a market value of $1.2 million at the date of issuance.



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Notes to the Consolidated Financial Statements (continued)



On March 1, 2006, the Company redeemed the remaining $78.9 million principal amount of the
subordinated convertible notes for $79.6 million. This eliminated the Companys long-term debt that was outstanding at December 31, 2005. The Company will recognize a charge of $1.2 million related to this payment and the write off of the
remaining deferred financing costs on March 1, 2006.



Senior Notes



To partially finance the
acquisition of Vancocin, ViroPharma issued $62.5 million aggregate principal amount of Senior Secured Bridge Notes due October 2005 (the senior notes) and warrants to purchase 5,000,000 shares of the Companys common stock at $0.01
per share (the warrants) in October 2004. The senior notes and the warrants were automatically exchanged for 6% Convertible Senior Secured Notes due October 2009 (the senior convertible notes) following stockholder approval
of the issuance of the senior convertible notes in January 2005.



Interest on the senior notes was payable monthly at an annual rate of 10% until shareholder approval of the exchange into the senior convertible notes in January 2005. One full year of interest payable of $10.0 million on the senior notes
was also placed into escrow and released as interest payments became due. Upon the exchange of senior notes for senior convertible notes in January 2005, the remaining $8.4 million balance of the unpaid escrowed interest for the senior notes was
released to the Company. Debt issuance costs of $3.8 million were capitalized and were being amortized over the life of the senior notes, which, until exchanged into the senior convertible notes, was one year. Upon the exchange, the estimated useful
life of these costs was revised and the unamortized costs were amortized over the life of the senior convertible notes.



In accordance with SFAS No. 6, Classification of Short-Term Obligations Expected to be Refinanced, the Company recorded the senior notes
as long-term debt as of December 31, 2004.



Senior
Convertible Notes



The senior notes and the warrants were
automatically exchanged in January 2005 for the senior convertible notes following stockholder approval of the issuance of the senior convertible notes. The $62.5 million value of the senior convertible notes, which were due in October 2009, were in
an amount equal to the aggregate principal amount of the senior notes for which the senior convertible notes were exchanged. In April 2005, the initial investors in the senior notes exercised their purchase option and acquired an additional $12.5
million of the senior convertible notes with identical terms.



The senior convertible notes were convertible into shares of common stock at the option of the holder at a conversion rate of $2.50 per share. The Company was also able to elect to automatically convert in any calendar quarter up to
twenty-five percent of the principal amount of the senior convertible notes into shares of its common stock if certain trading thresholds were met. When the investors voluntarily converted the senior convertible notes and when the Company effected
an auto-conversion of the senior convertible notes, the Company made additional payments on the principal amount converted equal to three full years of interest, less any interest actually paid or provided for prior to the conversion date. In the
case of a voluntary conversion by the investors, the Company was required to make this payment in cash. When the Company effected an auto-conversion, the Company elected to make the additional payment with shares of its common stock valued at 90% of
the volume weighted average price of the stock for the 10 days preceding the automatic conversion date, in accordance with the provisions of the senior convertible notes.



Through December 31, 2005, investors had voluntarily converted $40.8 million of principal amount on the senior
convertible notes into 16,360,000 shares of common stock and had received $6.8 million in cash related



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



make-whole interest payments, which reduced the derivative liability, as discussed below. Through December 31, 2005, the Company had auto-converted the
remaining principal amount of senior convertible notes into common stock. On June 27, 2005, the Company affected an auto-conversion of $18.8 million of principal amount on the senior convertible notes into 7,500,000 shares of common stock and
issued 516,674 shares of common stock as make-whole interest payments, in accordance with the auto-conversion terms in the indenture. The make-whole payment reduced the derivative liability by $3.1 million, which represented the cash value of the
make-whole payment, and increased interest expense by $0.6 million, which represents the beneficial conversion feature. The beneficial conversion feature is the result of the fair value of the 516,674 shares of common stock on the commitment date
exceeding the stock value as defined by the auto-conversion provisions. On July 12, 2005, the Company affected an auto-conversion of $15.4 million of principal amount on the senior convertible notes into 6,140,000 shares of common stock and
issued 381,831 shares of common stock as make-whole interest payments, in accordance with the auto-conversion terms summarized above. The make-whole payment eliminated the derivative liability, which represented the cash value of the make-whole
payment provision, and increased interest expense by approximately $0.9 million, which represented the beneficial conversion feature. The beneficial conversion feature is the result of the fair value of the 381,831 shares of common stock on the
commitment date exceeding the stock value as defined by the auto-conversion provisions. In addition, a portion of the discount on debt of $1.0 million was reduced through additional paid-in capital.



In accordance with SFAS No. 133, Accounting for Derivative
Instruments and Hedging Activities, as amended, the make-whole provision contained in the senior convertible notes is not clearly and closely related to the characteristics of the senior convertible notes. Accordingly, the make-whole provision
is an embedded derivative instrument and is required by SFAS No. 133 to be accounted for separately from the debt instrument. As a result, the Company recorded an $8.6 million derivative liability, which was the fair value of the make-whole
provision based on a Monte Carlo simulation at the time of issuance. The $8.6 million includes $7.9 million upon the conversion of the senior notes into senior convertible notes in January 2005 and $0.7 million upon exercise of the initial investors
purchase option in April 2005. This liability was reduced for interest payments on conversions during 2005 and eliminated the liability as of July 12, 2005, after which the senior convertible notes were no longer outstanding. Prior to
June 30, 2005, changes in the fair value of the derivative liability were measured using a Monte Carlo simulation model and are recorded as change in fair value of derivative liability in the consolidated statement of operations. The change in
fair value of derivative liability recorded in the statement of operations was a loss of $4.0 million for the year ended December 31, 2005.



The discount on debt of $8.6 million, resulting from the recording of the derivative liability, was accreted over the life of the senior convertible
notes, which was recorded as additional interest expense of $0.7 million for the year ended December 31, 2005. The remaining $7.9 million of discount on debt has been reduced through additional paid-in capital to reflect the conversions of
$75.0 million of senior convertible notes to common stock.



9.    Acquisition, License and Research Agreements



Vancocin Acquisition



In November 2004, the
Company acquired all rights in the U.S. and its territories to manufacture, market and sell the oral capsule formulation of Vancocin, as well as rights to certain related Vancocin products, from Lilly. Oral Vancocin is a potent antibiotic approved
by the U.S. Food and Drug Administration to treat antibiotic-associated pseudomembranous colitis caused by Clostridium difficileand enterocolitis caused by S. aureus(including methicillin-resistant strains). Lilly will retain its
rights to vancomycin outside of the U.S. and its territories.



Through this acquisition, the Company acquired certain know-how related to manufacturing of the product, the Vancocin trademark, starting material inventory, the active New Drug Application (NDA) for Vancocin as



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



well as additional rights relating to the injectable and oral solution formulations of vancomycin. In addition, the Company received certain related
intellectual property and other information and materials required to continue marketing the brand in the U.S. and its territories.



At closing, the Company and Lilly entered into a supply agreement and a transition services agreement. The process of qualifying the Companys own
third party supply chain is ongoing. Following the transition period, which ended in July 2005, the Company assumed responsibility for product inventory, sales, marketing and distribution of the Vancocin brand.



To acquire the rights to Vancocin, the Company paid an upfront cash payment
of $116.0 million, comprised of $53.5 million from the Companys existing cash and $62.5 million from the issuance of $62.5 million aggregate principal amount of Senior Notes and Warrants (see Note 8). The Company spent approximately $2.0
million in fees related to this transaction. In addition, Lilly is entitled to additional payments on annual net sales of Vancocin within certain defined levels of sales occurring between 2005 and 2011 (see Note 6). In 2005, the Company paid $10.5
million of these additional payments, which was accounted for as contingent consideration, increasing the carrying amount of the related intangible assets (see Note 6).



The Company recorded this transaction as an asset purchase with the purchase price and related transaction costs allocated
to specific tangible and intangible assets acquired. The assets will be amortized over their related useful lives (see Note 6).



Schering Plough Agreement



In November 2003, the Company entered into an agreement granting Schering-Plough Corporation (Schering-Plough) the option to license its
intranasal formulation of pleconaril for the treatment of the common cold in the U.S. and Canada. Under terms of the agreement, Schering-Plough paid the Company an up-front option fee of $3.0 million, which was recognized as revenue over its
estimated performance period, which ended in August 2004.



In
November 2004, the Company announced that Schering-Plough and it entered into a license agreement under which Schering-Plough has assumed responsibility for all future development and commercialization of pleconaril. Other than transitioning the
technology to Schering-Plough, the Company will have no further continuing operational involvement with the development and commercialization of the intranasal formulation of pleconaril for the treatment of the common cold. Upon the effective date
of the agreement, Schering-Plough paid the Company an initial license fee of $10.0 million, which was recorded as license fee and milestone revenue in 2004 consistent with the Companys revenue recognition policy. As part of the agreement,
Schering-Plough also purchased the Companys existing inventory of bulk drug substance for an additional $6.0 million during January 2005. The Company reviewed the factors surrounding this purchase and determined that since title had not passed
until 2005, the related revenue was recognized in the first quarter of 2005. The Company will also be eligible to receive up to an additional $65.0 million in milestone payments upon achievement of certain targeted regulatory and commercial events,
as well as royalties on Schering-Ploughs sales of intranasal pleconaril in the licensed territories.



SIGA Agreement



During
the third quarter of 2004, the Company sold certain of its non-core assets, including compounds, assays and other intellectual property related to the development of antiviral drugs targeting the smallpox virus and viral hemorrhagic fever viruses,
to SIGA Technologies, Inc. (SIGA), a company that focuses on the development of products for the prevention and treatment of infectious diseases, with an emphasis on products



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



for biological warfare defense. As consideration for such assets, SIGA paid the Company $1.0 million in cash and issued the Company one million shares of
SIGA common stock. The shares received were accounted for as available-for-sale securities and recorded at fair value as part of short-term investments as of December 31, 2005 and 2004. The gain on sale of these assets recognized by the Company
was $1.7 million on the date of this transaction, net of broker fees.



GlaxoSmithKline Agreement



In August 2003, the
Company announced the acquisition of worldwide rights (excluding Japan) from GlaxoSmithKline (GSK) to an antiviral compound (maribavir, or VP41263) that is an inhibitor of cytomegalovirus (CMV). The Company plans to advance maribavir initially for
the prevention and treatment of CMV infection in transplant patients.



Under the terms of the agreement, the Company has exclusive worldwide rights (excluding Japan) to develop and commercialize maribavir (VP41263) for the prevention and treatment of cytomegalovirus infections related to transplant (including
solid organ and hematopoietic stem cell transplantation), congenital transmission, and in patients with HIV infection. The Company will focus initially on patients who have received a hematopoietic stem cell (bone marrow) transplant, and are at risk
for or have been infected with CMV. The Company paid GSK a $3.5 million up-front licensing fee and may pay additional milestones based upon the achievement of defined clinical development and regulatory events, if any. The Company also will pay
royalties to GSK and its licensor on product sales in the U.S. and the rest of the world (excluding Japan). The $3.5 million up-front licensing fee was recorded as an acquisition of technology rights expense during 2003 as the underlying technology
has not reached technological feasibility and has no alternative uses.



Wyeth Agreement



In December 1999, the Company
entered into a licensing agreement with Wyeth for the discovery, development and commercialization of hepatitis C drugs. In connection with the signing of the agreement, the Company received $5.0 million from Wyeth. This amount is non-refundable and
a portion of it was recorded as deferred revenue at December 31, 1999. This revenue is being recognized as certain activities are performed by the Company over the estimated performance period. The original performance period was 5 years. In
2002, the Company and Wyeth extended the compound screening portion of the agreement by two years, and as a result the Company extended the performance period from 5 years to 7 years. The unamortized balance of the deferred revenue will be amortized
over the balance of the extended performance period. Of this deferred revenue, the Company recognized $0.6 million as revenue in each 2005, 2004 and 2003 and $0.6 million is recorded as deferred revenue on the consolidated balance sheet at
December 31, 2005. If drug candidates are successfully commercialized, the Company has the right to co-promote the products and share equally in the net profits in the U.S. and Canada. The Company is entitled to milestone payments upon the
achievement of certain development milestones and royalties for product sales, if any, outside of the U.S. and Canada.



In 2000, the Company sold an aggregate of 200,993 shares of common stock to Wyeth for aggregate proceeds of $6.0 million. The sales of common stock were
as a result of progress made under the companies hepatitis C virus collaboration. In connection with the collaboration and license agreement, Wyeth is required to purchase predetermined dollar amounts of additional shares of the Companys
common stock at a market value premium at the time of completion of certain product development stages. If additional shares are purchased, this excess will be accounted for as a credit to additional paid-in capital.



In June 2003, the Company amended its collaboration agreement with Wyeth to,
among other things, focus the parties screening activity on one target, to allocate more of the collaborations pre-development efforts to the



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



Company (subject to the Companys cost sharing arrangement with Wyeth for this work), and to clarify certain of the reconciliation and reimbursement
provisions of the collaboration agreement. In addition, under the amended agreement both companies are permitted to work outside the collaboration on screening against targets other than the target being addressed by each company under the
collaboration. In connection with the Companys restructuring in January 2004, it agreed with Wyeth that both parties would cease screening compounds against HCV under the collaboration. During the term of the agreement, the two parties will
work exclusively with each other on any promising compounds and in one particular HCV target.



Other Agreements



The
Company has entered into various other licensing, research and other agreements. Under these other agreements, the Company is working in collaboration with various other parties. Should any discoveries be made under such arrangements, the Company
would be required to negotiate the licensing of the technology for the development of the respective discoveries. There are no significant funding commitments under any of these other agreements.



10.    Stockholders Equity



Preferred Stock



The Companys Board of Directors has the authority, without action by the holders of common stock, to issue up to
4,800,000 additional shares of preferred stock from time to time in such series and with such preference and rights as it may designate.



The Company adopted a Stockholders Rights Plan (the Plan) in September 1998. In connection with the Plan, the Company designated from
its Preferred Stock, par value $.001 per share, Series A Junior Participating Preferred Stock, par value $.001 per share (the Series A Preferred Shares), and reserved 200,000 Series A Preferred Shares for issuance under the Plan, which
the Board has the authority to modify when deemed necessary. The Company declared a dividend distribution of one right for each outstanding share of common stock. The rights entitle stockholders to purchase one one-hundredth of a share of Series A
Junior Participating Preferred Stock. The rights expire in 2008. Each holder of a right, other than the acquiring person, would be entitled to purchase $250 worth of common stock of the Company for each right at the exercise price of $125 per right,
which would effectively enable such rights holders to purchase common stock at one-half of the then current price. At December 31, 2005, the rights were neither exercisable nor traded separately from the Companys common stock, and become
exercisable only if a person or group becomes the beneficial owner of 20% or more of the Companys common stock or announces a tender offer which would result in ownership of 20% or more of the Companys common stock.



Common Stock



In July 2001, the Company filed a Form S-3 universal shelf registration statement with the Securities and Exchange
Commission (the SEC) for the registration and potential issuance of up to $300 million of the Companys securities, of which $39 million remained at December 31, 2005. On October 19, 2001 the SEC declared the registration
statement effective.



In December 2005, the Company entered
into an underwriting agreement with Goldman, Sachs & Co., Piper Jaffray, Lazard Capital Markets and SG Cowen & Co. for the sale of 10,350,000 shares of its common stock at $16.75 per share. The sale was completed on
December 12, 2005 and net proceeds from the sale were approximately $163.5 million.



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Notes to the Consolidated Financial Statements (continued)



11.    Equity Compensation Plans



Employee Stock Option Plans



The company currently has three option plans in place: a 1995 Stock Option
and Restricted Share Plan (1995 Plan), a 2001 Equity Incentive Plan (2001 Plan) and a 2005 Stock Option and Restricted Share Plan (2005 Plan) (collectively the Plans). In September 2005, the 1995 Plan
expired. The Plans were adopted by the companys board of directors to provide eligible individuals with an opportunity to acquire or increase an equity interest in the Company and to encourage such individuals to continue in the employment of
the Company.



Stock options granted under the 1995 Plan and
2005 Plan must be granted at an exercise price not less than the fair value of the Companys common stock on the date of grant. Stock options granted under the 2001 Plan can be granted at an exercise price that is less than the fair value of
the Companys common stock at the time of grant. Stock options granted from the Plans are exercisable for a period not to exceed ten years from the date of grant. Vesting schedules for the stock options vary, but generally vest 25% per
year, over four years. The Plans provide for the delegation of certain administrative powers to a committee comprised of company officers. As a result of an amendment to the 1995 Plan in 2001, a provision that accelerates the vesting of unvested
options under certain circumstances upon a change of control of the Company was modified to normalize the accelerated vesting across all option holders.



As of December 31, 2005, there were 1,076,237 shares available for grant under the Plans. The following table lists the balances available by Plan at
December 31, 2005:



|                                            |  |            |   |  |           |   |  |           |   |  |            |  
|------------------------------------------- |  | ---------- | - |  | --------- | - |  | --------- | - |  | ---------- | -
|                                            |  | 1995 Plan  |   |  | 2001 Plan |   |  | 2005 Plan |   |  | Combined   |  
|Number of shares authorized                 |  | 4,500,000  |   |  | 500,000   |   |  | 850,000   |   |  | 5,850,000  |  
|Number of options granted since inception   |  | (6,997,515 | ) |  | (991,600  | ) |  | (42,000   | ) |  | (8,031,115 | )
|Number of options cancelled since inception |  | 2,831,824  |   |  | 759,837   |   |  |          |   |  | 3,591,661  |  
|Number of shares expired                    |  | (334,309   | ) |  |          |   |  |          |   |  | (334,309   | )
|                                            |  |            |   |  |           |   |  |           |   |  |            |  
|Number of shares available for grant        |  |           |   |  | 268,237   |   |  | 808,000   |   |  | 1,076,237  |  
|                                            |  |            |   |  |           |   |  |           |   |  |            |  



The following table
lists option grant activity for the three year period ending December 31, 2005:



|                             |  |              |   |  |                                        |      
|---------------------------- |  | ------------ | - |  | -------------------------------------- | -----
|                             |  | ShareOptions |   |  | Weightedaverageexercise priceper share
|Balance, December 31, 2002   |  | 3,355,137    |   |  | $                                      | 13.22
|Granted                      |  | 807,000      |   |  |                                        | 2.11 
|Exercised                    |  | (8,150       | ) |  |                                        | 0.35 
|Canceled                     |  | (328,227     | ) |  |                                        | 16.36
|                             |  |              |   |  |                                        |      
|Balance, December 31, 2003   |  | 3,825,760    |   |  |                                        | 10.63
|Granted                      |  | 1,007,800    |   |  |                                        | 3.01 
|Exercised                    |  | (279,480     | ) |  |                                        | 0.90 
|Canceled                     |  | (1,851,909   | ) |  |                                        | 11.72
|                             |  |              |   |  |                                        |      
|Balance at December 31, 2004 |  | 2,702,171    |   |  |                                        | 8.05 
|Granted                      |  | 1,094,920    |   |  |                                        | 5.40 
|Exercised                    |  | (540,986     | ) |  |                                        | 2.74 
|Canceled                     |  | (121,900     | ) |  |                                        | 9.01 
|                             |  |              |   |  |                                        |      
|Balance at December 31, 2005 |  | 3,134,205    |   |  | $                                      | 8.00 
|                             |  |              |   |  |                                        |      



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



The Company has 3.1 million option grants outstanding at December 31, 2005 with exercise
prices ranging from $0.99 per share to $38.70 per share and a weighted average remaining contractual life of 7.47 years. Of the 3.1 million option grants outstanding, the Company has 1.3 million exercisable option grants at
December 31, 2005 with a weighted average exercise price of $12.73 per share. The following table lists the outstanding and exercisable option grants as of December 31, 2005:



|                                |  |                     |  |                                                  |  |                                        |       |                        |           |                               |   |      
|------------------------------- |  | ------------------- |  | ------------------------------------------------ |  | -------------------------------------- | ----- | ---------------------- | --------- | ----------------------------- | - | -----
|                                |  | Options Outstanding |  | Options Exercisable                             
|Exercise Price Range of Options |  | ShareOptions        |  | Weighted averageremainingcontractual life(Years) |  | Weightedaverageexercise priceper share |       | As ofDecember 31, 2005 |           | Weightedaverage exerciseprice
|$    0.99-2.71                  |  | 755,125             |  | 7.88                                             |  | $                                      | 2.07  |                        | 318,302   |                               | $ | 1.78 
|2.91-3.14                       |  | 634,420             |  | 9.03                                             |  |                                        | 3.10  |                        | 10,000    |                               |   | 2.94 
|3.33-7.05                       |  | 894,180             |  | 8.35                                             |  |                                        | 4.93  |                        | 255,750   |                               |   | 3.67 
|8.38-21.13                      |  | 671,130             |  | 4.99                                             |  |                                        | 17.56 |                        | 568,630   |                               |   | 17.83
|22.44-38.70                     |  | 179,350             |  | 5.07                                             |  |                                        | 29.85 |                        | 172,063   |                               |   | 30.13
|                                |  |                     |  |                                                  |  |                                        |       |                        |           |                               |   |      
|$   0.99-38.70                  |  | 3,134,205           |  | 7.47                                             |  | $                                      | 8.00  |                        | 1,324,745 |                               | $ | 12.73
|                                |  |                     |  |                                                  |  |                                        |       |                        |           |                               |   |      



Options granted during
2005, 2004 and 2003 had weighted average fair values per option of $4.43, $2.68 and $1.86, respectively. The fair value of each option grant was estimated throughout the periods using the Black-Scholes option-pricing model using the following
weighted-average assumptions for the Plans:



|                                 |  |      |   |  |      |   |  |      |  
|-------------------------------- |  | ---- | - |  | ---- | - |  | ---- | -
|                                 |  | 2005 |   |  | 2004 |   |  | 2003 |  
|Expected dividend yield:         |  |     |   |  |     |   |  |     |  
|Risk free interest rate:         |  | 4.1  | % |  | 3.9  | % |  | 3.7  | %
|Volatility:                      |  | 127  | % |  | 141  | % |  | 149  | %
|Expected option life (in years): |  | 4.9  |   |  | 5.8  |   |  | 5.4  |  



Employee Stock Purchase Plan



In 2000, the stockholders of the Company approved an
employee stock purchase plan. A total of 300,000 shares originally were available under this plan. Since inception of the plan, the stockholders of the Company approved an amendment to the plan to increase the number of shares available for issuance
under the plan by 300,000 shares. Under this plan, employees may purchase common stock through payroll deductions in semi-annual offerings at a price equal to the lower of 85% of the closing price on the applicable offering commencement date or 85%
of the closing price on the applicable offering termination date. Under this plan 15,894, 16,273 and 48,438 shares were sold to employees during 2005, 2004 and 2003, respectively. As of December 31, 2005 there are approximately 307,575 shares
remaining under this plan. The plan qualifies under Section 423 of the Internal Revenue Code.



Restricted Common Stock



In 2000, the Company issued 50,000 shares of restricted common stock to the Chief Executive Officer of the Company. These shares vest ratably over 48 months. The fair value of such stock at the respective issuance dates was $1.1 million.
This amount is reflected in deferred compensation and is being amortized to operations over the vesting period. There was no compensation expense related to this issuance for the year ended December 31, 2005. During the years ended
December 31, 2004 and 2003 compensation expense related to this issuance was $0.2 million. During 2005, 2004 and 2003, the Company issued no shares of restricted common stock.



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



12.    Income Taxes



For the years ended December 31, 2003 and 2004, the Company had no income tax expense or benefit.



For the year ended December 31, 2005, the following table summarizes the
components of income before income taxes and the benefit for income taxes:



|                                    |  |                              |         |  
|----------------------------------- |  | ---------------------------- | ------- | -
|(in thousands)                      |  | Year ended December 31, 2005 |        
|Income before income taxes          |  | $                            | 75,900  |  
|                                    |  |                              |         |  
|(Benefit) expense for income taxes: |  |                              |         |  
|Current:                            |  |                              |         |  
|Federal                             |  | $                            | 7,797   |  
|State and local                     |  |                              | 2,153   |  
|                                    |  |                              |         |  
|Subtotal                            |  |                              | 9,950   |  
|                                    |  |                              |         |  
|Deferred:                           |  |                              |         |  
|Federal                             |  |                              | (44,196 | )
|State and local                     |  |                              | (3,559  | )
|                                    |  |                              |         |  
|Subtotal                            |  |                              | (47,755 | )
|                                    |  |                              |         |  
|Benefit from income taxes           |  | $                            | (37,805 | )
|                                    |  |                              |         |  



For the year ended
December 31, 2005, the following table summarizes the principal elements of the difference between the effective income tax rate and the federal statutory income tax rate:



|                                                                 |  |                             |   
|---------------------------------------------------------------- |  | --------------------------- | --
|                                                                 |  | Year endedDecember 31, 2005 |   
|U.S. federal statutory income tax rate                           |  | 35.0                        | % 
|State and local income benefit, net of federal income tax effect |  | (1.2                        | ) 
|Derivative mark to market on convertible notes                   |  | 1.9                         |   
|Interest on convertible notes                                    |  | 0.9                         |   
|Conversions of convertible notes                                 |  | 1.2                         |   
|Change in valuation allowance                                    |  | (87.6                       | ) 
|                                                                 |  |                             |   
|Effective income tax benefit rate                                |  | (49.8                       | )%
|                                                                 |  |                             |   



The following table
summarizes the change in the valuation allowance:



|                                         |  |                  |        
|---------------------------------------- |  | ---------------- | -------
|(in thousands)                           |  | December 31,2005
|Valuation allowance at beginning of year |  | $                | 122,529
|                                         |  |                  |        
|Credited to expense                      |  |                  | 72,300 
|Credited to additional paid-in capital   |  |                  | 1,169  
|                                         |  |                  |        
|Valuation allowance at end of year       |  | $                | 49,060 
|                                         |  |                  |        



When considering a
reduction in the valuation allowance, the Company considers the level of past and future taxable income, the utilization of the carryforwards and other factors. Based upon these considerations, the Company credited to expense a reduction to the
valuation allowance of $72.3 million in the fourth quarter of



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



2005, $24.5 million of which related to the current year. The remaining $47.8 million relates to the portion of deferred tax assets that management believes
it is more likely than not will be realized in future periods. The $1.2 million credited to additional paid-in capital represents the portion of the valuation allowance related to the beginning of the year. The Company also recorded $2.0 million
related to current stock option tax benefits. The valuation allowance increased by $5.8 million during 2004 as a result of changes in deferred tax assets, which were fully offset by the valuation allowance.



The following table summarizes the components of deferred income tax assets
and liabilities:



|                                             |  |              |         |   |      |   |          |  
|-------------------------------------------- |  | ------------ | ------- | - | ---- | - | -------- | -
|                                             |  | December 31, |        
|(in thousands)                               |  | 2005         |         |   | 2004 |  
|Deferred tax assets:                         |  |              |         |   |      |   |          |  
|Net operating loss carryforwards             |  | $            | 50,568  |   |      | $ | 64,064   |  
|Capitalized research and development costs   |  |              | 37,014  |   |      |   | 47,286   |  
|Research and development credit carryforward |  |              | 9,158   |   |      |   | 9,604    |  
|Non-deductible reserves                      |  |              | 1,278   |   |      |   | 1,156    |  
|Depreciation and amortization                |  |              | 366     |   |      |   | 383      |  
|Other                                        |  |              | 394     |   |      |   | 655      |  
|                                             |  |              |         |   |      |   |          |  
|Subtotal                                     |  |              | 98,778  |   |      |   | 123,148  |  
|Valuation allowance                          |  |              | (49,060 | ) |      |   | (122,529 | )
|                                             |  |              |         |   |      |   |          |  
|Deferred tax assets                          |  |              | 49,718  |   |      |   | 619      |  
|                                             |  |              |         |   |      |   |          |  
|Deferred tax liabilities:                    |  |              |         |   |      |   |          |  
|Intangible amortization                      |  |              | 1,127   |   |      |   |         |  
|Prepaid expenses                             |  |              | 72      |   |      |   | 619      |  
|                                             |  |              |         |   |      |   |          |  
|Deferred tax liabilities                     |  |              | 1,199   |   |      |   | 619      |  
|                                             |  |              |         |   |      |   |          |  
|Net deferred tax assets                      |  | $            | 48,519  |   |      | $ |         |  
|                                             |  |              |         |   |      |   |          |  



Due to the uncertainty
of the Companys ability to realize the benefit of all of the deferred tax assets, the deferred tax assets are partially offset by a valuation allowance. The Company believes that it is more likely than not that the remaining net deferred tax
assets will be utilized in future periods.



The following table
indicates where net deferred income taxes have been classified in the Consolidated Balance Sheet:



|                                       |  |                  |        |                  |   |  
|-------------------------------------- |  | ---------------- | ------ | ---------------- | - | -
|(in thousands)                         |  | December 31,2005 |        | December 31,2004
|Deferred income tax assetscurrent     |  | $                | 11,644 |                  | $ | 
|Deferred income tax assetsnon-current |  |                  | 36,875 |                  |   | 
|                                       |  |                  |        |                  |   |  
|Net deferred income tax assets         |  | $                | 48,519 |                  | $ | 
|                                       |  |                  |        |                  |   |  



The
following table summarizes carryforwards of net operating losses and tax credits as of December 31, 2005.



|                                 |  |        |         |            |             
|-------------------------------- |  | ------ | ------- | ---------- | ------------
|(in thousands)                   |  | Amount |         | Expiration
|Federal net operating losses     |  | $      | 116,997 |            | 2020 to 2024
|State net operating losses       |  |        | 148,217 |            | 2007 to 2024
|Research and development credits |  |        | 9,158   |            | 2009 to 2024



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



13.    Earnings per share



|                                                            |  |                                 |         |      |   |         |      |  |   |         |  
|----------------------------------------------------------- |  | ------------------------------- | ------- | ---- | - | ------- | ---- |  | - | ------- | -
|(in thousands, except per share data)                       |  | For the years endedDecember 31, |        
|                                                            |  | 2005                            |         | 2004 |   |         | 2003 | 
|Basic Earnings Per Share                                    |  |                                 |         |      |   |         |      |  |   |         |  
|Net income (loss)                                           |  | $                               | 113,705 |      | $ | (19,534 | )    |  | $ | (36,942 | )
|Common stock outstanding                                    |  |                                 | 44,334  |      |   | 26,578  |      |  |   | 25,916  |  
|                                                            |  |                                 |         |      |   |         |      |  |   |         |  
|Basic net income (loss) per share                           |  | $                               | 2.56    |      | $ | (0.73   | )    |  | $ | (1.43   | )
|                                                            |  |                                 |         |      |   |         |      |  |   |         |  
|Diluted Earnings Per Share                                  |  |                                 |         |      |   |         |      |  |   |         |  
|Net income (loss)                                           |  | $                               | 113,705 |      | $ | (19,534 | )    |  | $ | (36,942 | )
|Add interest expense on senior convertible notes            |  |                                 | 2,641   |      |   |        |      |  |   |        |  
|                                                            |  |                                 |         |      |   |         |      |  |   |         |  
|Diluted net income (loss)                                   |  | $                               | 116,346 |      | $ | (19,534 | )    |  | $ | (36,942 | )
|Common stock outstanding                                    |  |                                 | 44,334  |      |   | 26,578  |      |  |   | 25,916  |  
|Add shares on senior convertible notes                      |  |                                 | 11,959  |      |   |        |      |  |   |        |  
|Add in-the-money stock options                            |  |                                 | 1,317   |      |   |        |      |  |   |        |  
|                                                            |  |                                 |         |      |   |         |      |  |   |         |  
|Common stock assuming conversion and stock option exercises |  |                                 | 57,610  |      |   | 26,578  |      |  |   | 25,916  |  
|                                                            |  |                                 |         |      |   |         |      |  |   |         |  
|Diluted net income (loss) per share                         |  | $                               | 2.02    |      | $ | (0.73   | )    |  | $ | (1.43   | )
|                                                            |  |                                 |         |      |   |         |      |  |   |         |  



For the year ended
December 31, 2005, diluted net income per share of $2.02 excludes approximately 938,000 shares related to the subordinated convertible notes as their effect would be anti-dilutive and approximately 830,000 shares related to stock options that
were not in-the-money as of December 31, 2005. For the years ended December 31, 2004 and 2003, diluted net loss per share of $0.73 and $1.43 is calculated using basic common shares outstanding since including potential common
shares of 2.7 million in 2004 and 3.8 million in 2003 would be anti-dilutive.



14.    401(k) Employee Savings Plan



In 1998, the Company adopted a new 401(k) Employee Savings Plan (the 401(k) Plan) available to all employees meeting certain eligibility criteria. The 401(k) Plan permits participants to contribute up to
92% of their compensation not to exceed the limits established by the Internal Revenue Code. Participants are always fully vested in their contributions. The Company matches of 25% on the first 6% of participating employee contributions. The Company
contributed approximately $47,000, $60,000 and $81,000 to the 401(k) Plan in each of the years ended December 31, 2005, 2004 and 2003, respectively. The Companys contributions are made in cash. The Companys common stock is not an
investment option available to participants in the 401(k) Plan.



15.    Commitments and Contingencies



The Company currently leases 33,000 square feet in Exton, Pennsylvania for its marketing, development and corporate activities under an operating lease expiring in 2017. The total remaining obligation under this lease
is $8.1 million. The lease provides the Company two consecutive optional renewal terms of five years each.



As part of the manufacturing agreement with Lilly, the Company has certain minimum purchase requirements of Vancocin for a period of time less than one
year, on a rolling basis, which at December 31, 2005 totaled $3.4 million. The Company is not contractually obligated to any amount of purchases other than in connection with the purchase orders processed for finished goods based on the rolling
basis, and cannot reasonably estimate the amount of Vancocin which it may be obligated to purchase in the future. In December



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



2005, the Company entered into an agreement with OSG Norwich Pharmaceuticals, Inc. (OSG Norwich) for the manufacture of finished product, which
expires in December 2010. In this agreement for Vancocin finished product, the Company is obligated to purchase 80% of its finished product requirements from OSG Norwich (other than such requirements filled by Lilly through September 2006), provided
that OSG Norwich has sufficient capacity to meet such requirements.



The Companys future minimum lease payments under the aforementioned lease and other operating leases related to equipment for years subsequent to December 31, 2005 are as follows (in thousands):



|                         |  |             |      
|------------------------ |  | ----------- | -----
|Year ending December 31, |  | Commitments
|2006                     |  | $           | 671  
|2007                     |  |             | 683  
|2008                     |  |             | 653  
|2009                     |  |             | 659  
|2010                     |  |             | 673  
|Thereafter               |  |             | 4,878
|                         |  |             |      
|Total minimum payments   |  | $           | 8,217
|                         |  |             |      



Rent expense for the
years ended December 31, 2005, 2004, and 2003 aggregated $0.7 million, $0.9 million and $1.8 million, respectively.



The Company has a severance plan and severance agreements for certain employees and change of control agreements for executive officers and certain other
employees. Under its severance plan and severance agreements, certain employees may be provided separation benefits from the Company if they are involuntarily separated from employment. Under the Companys change of control agreements, certain
employees are provided separation benefits if they are either terminated or resign for good reason from the Company within 12 months from a change of control.



16. Restructuring



2005 Actions



There were no restructuring actions in 2005.



2004 Actions



In January 2004, the Company announced that it had restructured its organization to focus its resources on the advancement and development of later stage
products. As a result of this restructuring, the Company reduced its workforce by 70% from December 2003 levels. This reduction was the result of the Company discontinuing its early stage activities, including discovery research and most internal
preclinical activities, and reductions in clinical development and general and administrative personnel. During the first nine months of 2004, the Company included $9.2 million of severance and asset impairment costs related to this restructuring in
the consolidated financial statements. The following table reflects the charges recorded during the year ended December 31, 2004:



|                                                         |  |                          |       |     |   |       |       |  |   |       |  
|-------------------------------------------------------- |  | ------------------------ | ----- | --- | - | ----- | ----- |  | - | ----- | -
|                                                         |  | Research and Development |       | G&A |   |       | Total | 
|(in thousands)                                           |  |                          |       |     |   |       |       | 
|Severance                                                |  | $                        | 3,579 |     | $ | 922   |       |  | $ | 4,501 |  
|Asset impairments                                        |  |                          |      |     |   | 5,169 |       |  |   | 5,169 |  
|Additional proceeds from the sale of unused fixed assets |  |                          |      |     |   | (422  | )     |  |   | (422  | )
|                                                         |  |                          |       |     |   |       |       |  |   |       |  
|Total                                                    |  | $                        | 3,579 |     | $ | 5,669 |       |  | $ | 9,248 |  



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ViroPharma Incorporated

Notes to the Consolidated Financial Statements (continued)



During the third quarter of 2004, the restructuring charge was adjusted. The balance of all
restructuring obligations was paid by the end of 2004. Therefore, as of December 31, 2004, no restructuring accrual remained.



17.    Supplemental Cash Flow Information



|                                                                                  |  |                         |        |   |      |   |        |  
|--------------------------------------------------------------------------------- |  | ----------------------- | ------ | - | ---- | - | ------ | -
|                                                                                  |  | Year ended December 31, |       
|                                                                                  |  | 2005                    |        |   | 2004 |  
|(in thousands)                                                                    |  |                         |        |   |      |  
|Supplemental disclosure of non-cash transactions:                                 |  |                         |        |   |      |   |        |  
|Non-cash conversion of senior convertible notes, net of non-cash costs of $11,219 |  | $                       | 63,781 |   |      | $ |       |  
|Non-cash debt discount upon issuance of senior convertible notes                  |  |                         | 8,587  |   |      |   |       |  
|Non-cash conversion of senior notes to senior convertible notes                   |  |                         | 62,500 |   |      |   |       |  
|Issuance of stock for make-whole payments on auto conversions                     |  |                         | 5,649  |   |      |   |       |  
|Non-cash interest expense for beneficial conversion on make-whole payments        |  |                         | 1,489  |   |      |   |       |  
|Write-off of accrued interest to additional paid-in capital for auto conversions  |  |                         | 766    |   |      |   |       |  
|Stock received from sale of Bio-defense assets                                    |  |                         |       |   |      |   | (1,015 | )
|Unrealized gains (losses) on available for sale securities                        |  |                         | (497   | ) |      |   | 248    |  
|Supplemental disclosure of cash flow information:                                 |  |                         |        |   |      |   |        |  
|Cash paid for interest                                                            |  | $                       | 7,410  |   |      | $ | 8,661  |  
|Cash paid for taxes                                                               |  |                         | 9,532  |   |      |   |       |  



18.    Quarterly Financial Information (unaudited)



This table summarizes the unaudited consolidated financial results of operations for the quarters ended (amounts in thousands except per share data):



|                                        |  |           |         |   |          |   |         |               |  |   |              |   |  |   |         |  
|--------------------------------------- |  | --------- | ------- | - | -------- | - | ------- | ------------- |  | - | ------------ | - |  | - | ------- | -
|                                        |  | March 31, |         |   | June 30, |   |         | September 30, |  |   | December 31, |  
|2005 Quarter Ended                      |  |           |         |   |          |   |         |               |  |   |              |   |  |   |         |  
|Revenues                                |  | $         | 27,196  |   |          | $ | 28,965  |               |  | $ | 35,798       |   |  | $ | 40,458  |  
|Gross Product Margin (1)                |  |           | 17,441  |   |          |   | 24,394  |               |  |   | 30,647       |   |  |   | 35,342  |  
|Operating Expenses                      |  |           | (9,810  | ) |          |   | (10,259 | )             |  |   | (11,940      | ) |  |   | (12,263 | )
|Income Tax Expense (Benefit)            |  |           |        |   |          |   | 3,813   |               |  |   | 3,292        |   |  |   | (44,910 | )
|Net Income (Loss)                       |  |           | 17,374  |   |          |   | 4,981   |               |  |   | 18,652       |   |  |   | 72,698  |  
|Basic net (loss) income per share (2)   |  | $         | 0.64    |   |          | $ | 0.15    |               |  | $ | 0.33         |   |  |   | 1.21    |  
|                                        |  |           |         |   |          |   |         |               |  |   |              |   |  |   |         |  
|Diluted net (loss) income per share (2) |  | $         | 0.36    |   |          | $ | 0.11    |               |  | $ | 0.31         |   |  |   | 1.17    |  
|                                        |  |           |         |   |          |   |         |               |  |   |              |   |  |   |         |  
|2004 Quarter Ended                      |  |           |         |   |          |   |         |               |  |   |              |   |  |   |         |  
|Revenues                                |  | $         | 1,737   |   |          | $ | 1,765   |               |  | $ | 398          |   |  | $ | 18,489  |  
|Gross Product Margin (1)                |  |           |        |   |          |   |        |               |  |   |             |   |  |   | 6,631   |  
|Operating Expenses                      |  |           | (16,610 | ) |          |   | (5,359  | )             |  |   | (3,718       | ) |  |   | (8,711  | )
|Net Income (Loss)                       |  |           | (16,616 | ) |          |   | (5,378  | )             |  |   | (3,331       | ) |  |   | 5,791   |  
|Basic net (loss) income per share (2)   |  | $         | (0.63   | ) |          | $ | (0.20   | )             |  | $ | (0.13        | ) |  | $ | 0.22    |  
|Diluted net (loss) income per share (2) |  | $         | (0.63   | ) |          | $ | (0.20   | )             |  | $ | (0.13        | ) |  | $ | 0.22    |  
|                                        |  |           |         |   |          |   |         |               |  |   |              |   |  |   |         |  

---

|(1) |  | Gross product margin is calculated as net product sales less cost of sales.
|--- |  | ---------------------------------------------------------------------------

|(2) |  | Net (loss) income per share amounts will not agree to the per share amounts for the full year due to the use of weighted average shares for each period.
|--- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------



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