Revision date: 30 June 2011

Version: 2 .0 Page 1 of 11 

### SAFETY DATA SHEET

SECTION 1

- IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE

COMPANY/UNDERTAKING

Emergency telephone

number (Chemtrec): 1

- (800) 424

- 9300 (US and

Canada)

1- (703) 527- 3887 (Collect

calls accepted)

Product identifier

Synonyms

Trade names

Chemical family

Relevant identified uses of

the substance or mixture

and uses advised against To be handled by trained personnel f or research and development purposes only.

Note The pharmacologic and tox icologic properties of this have not been fully

characterized; this SDS will be revisited as more data become available.

Issue Date 30 June 2011

SECTION 2

- HAZARDS IDENTIFICATION

Classification of the

substance or mixture

Regulation (EC)

1272/2008 [GHS] Skin Sensitizer

- Category 1. not yet fully tested

Directive 67/548/EEC or

1999/45/EC Xi

- R43. not yet fully tested

Label elementsRevision date: 30 June 2011

Version: 2 .0 Page 2 of 11 SECTION 2

- HAZARDS IDENTIFICATION ...continued

CLP/GHS hazard

pictogram

CLP/GHS signal word Warning

CLP/GHS hazard

statements H317

- May cause allergic skin reaction.

CLP/GHS precautionary

statements P261

- Avoid breathing mist/vapor/spray . P272

- Contaminated work clothing

should not be allowed out of the workplace. P280 - Wear protective gloves/e ye

protection/face protection. P302 + P352 - If on skin: Wash with plenty of soap and

water. P333 + P313 - If skin irritation or rash occurs: Get medical advice/attention.

P363 - Wash cont aminated clothing before reuse. P501 - Dispose of

contents/container to location in accordance with

local/regional/national/international regulations.

Other hazards No information identified.

US Signal word Warning

US Hazard overview May cause allergic skin reaction. not yet fully tested.

Note This is classified as hazardous according to Directive 67/548/EEC

, Regulation EC No 1272/2008 (EU

- CLP), and applicable US regulations. The

pharmacological, toxicological, and ecological properties have not been fully

characterized. See Section 16 for full text of EU and GHS classifications. The

GHS classifications are based on Regu lation (EC) 1272/2008.

SECTION 3

- COMPOSITION/INFORMATION ON INGREDIENTS

Ingredient CAS # EINECS/ELIN

CS# Amount EU

Classification GHS

Classification

Not classified Not classified

Xi

- Irritant:

R43 SS1: H317Revision date: 30 June 2011

Version: 2 .0 Page 3 of 11 SECTION 3

- COMPOSITION/INFORMATION ON INGREDIENTS ...continued

Note The ingredient(s) listed a bove are considered hazardous. The pharmacological and

toxicological characteristics of this have not been fully characterized. See

Section 16 for full text of EU and GHS classifications. The EU classification is

based on Directive 67/548/EEC and the GHS classification is based on Regulation

(EC) 1272/2008.

SECTION 4

- FIRST AID MEASURES

Description of first aid

measures

Immediate Medical

Attention Needed Yes

Eye Contact If easy to do, remove contact lens es, if worn. Immediately flush eyes with copious

quantities of water for at least 15 minutes. If irritation occurs or persists, notify

medical personnel and supervisor.

Skin Contact Wash exposed area with soap and water and remove contaminated clothing/shoes.

If irritation occurs or persists, notify medical personnel and supervisor.

Inhalation Immediately move exposed subject to fresh air. If not breathing , give artificial

respiration. If breathing is labored, admin ister oxygen. Immediately notify medical

personnel and supervisor.

Ingestion If swallowed, call a physician immediately. Do not induce vomiting unless

directed by medical personnel. Do not give anything to drink unless directed by

medical personnel. Never give anything by mouth to an unconscious person.

Notify medical personnel and supervisor.

Protection of first aid

responders See Section 8 for Exposure Controls/Personal Protection recommendations.

Most important symptoms

and effects, both acute and

delayed See Sections 2 and 11

Indication of immediate

medical attention and

special treatment needed, if

necessary Treat sym ptomatically and supportively. If accidental exposure occurs to an

individua l who is also taking one or more concomitant medications, consult the

respective package or prescribing information for potential drug interactions.

SECTION 5

- FIREFIGHTING MEASURES

Extinguishing media Use water spray (fog), foam, dry powder, or carbon dioxide, as appropriate for

surrounding fire and materials.Revision date: 30 June 2011

Version: 2 .0 Page 4 of 11 SECTION 5

- FIREFIGHTING MEASURES ...continued

Specific hazards arising

from the substance or

mixture No information identified. May e mit toxic fumes of carbon monoxide and carbon

dioxide.

Flammability/Explosivity No explosivity or flammability data identified. High airborne concentrations of

finely divided organic particles can potentially explode if ignited.

Advice for firefighters Wear full protective clothing and a self

- contained breathing apparatus with a full

facepiece operated in the pressure demand or other positive pressure mode.

Decontaminate all equipment after use.

SECTION 6

- ACCIDENTAL RELEASE MEASURES

Personal precautions,

protective equipment and

emergency procedures If product is released or spilled, take proper precautions to minimize exposure by

using appropriate personal protective equipment (see Section 8). Area should be

adequately ventilated.

Environmental precautions Do not empty into drains. Avoid release to the environment.

Methods and material for

containment and cleaning

up For small spills (such as in a laboratory), soak up material with absorbent, e.g.,

damp paper towel, and wash spill area t horoughly with soap and water. For large

spills in manufacturing, use an industrial vacuum cleaner equipped with a high

efficiency par ticula te (HEPA) filter if available. Alternatively if in solid or dried

form

, do not raise dust. Surround spill or powder with absorbents and place a

damp cloth or towel over the area to minimize powder from entering the air. Add

excess liquid to allow for t he material to enter solution. Capture remaining liquid

onto spill absorbents. Place spill materials into a leak

- proof co ntainer suitable for

disposal. Dec ontaminate area a second time. Dispose of material in a manner that

is compliant with federal, stat e and local laws.

Reference to other sections See Sections 8 and 13 for more information.

SECTION 7

- HANDLING AND STORAGE

Precautions for safe

handling Avoid contact with eyes, skin and other mucous membranes. W ash thoroughly

after handling. Use personal protective equipment. Avoid breathing vapor. Do not

eat, drink or smoke while handling this product. Avoid prolonged or repeated

exposure. Provide sufficient air exchange and/or exhaust in workrooms. Take

precautionary measures against static discharges. Use normal preventative fire

protection measures.

Conditions for safe storage

including any

incompatibilities Keep container tightly closed. Keep in a cool and well ventilated area away from

any ignition source. To maintain product quality, do not store in heat or direct

sunlight.Revision date: 30 June 2011

Version: 2 .0 Page 5 of 11 SECTION 7

- HANDLING AND STORAGE ...continued

Specific end use(s) No information identified.

SECTION 8

- EXPOSURE CONTROLS/PERSONAL PROTECTION

Control

Parameters/Occupational

Exposure Limit Values

Compound Issuer Type OEL

-- -- --

-- -- --

Exposure/Engineering

controls Selection and use of containment devices and personal protective equipment

should be based on a risk assessment of exposure potential. Use local exhaust and/

or enclosure at mist/aerosol/spray

- generating points. High

- energy operations such

as spraying shou ld be done within an approved emission control or containment

system.

Respiratory protection Choice of respiratory protection should be appropriate to the task and the level of

existing engineering controls. An approved and properly fitted air

- purifying

respirator with HEPA filters should provide ancillary protection based on the

known or foreseeable limitations of existing engineering controls. Use a powered

air

- purifying respirator equipped with HEPA filters or combination filters or a

positive

- pressure air

- supplied respirator if there is any potential for an

uncontrolled release, when exposure levels are not known, or in any other

circumstances where a lower level of respiratory protection may not provide

ad equate protection.

Hand protection Wear nitrile or other impervious gloves if skin contact is possible. Double gloves

should be considered. When the material is dissolved or suspended in an organic

solvent, wear glov es that provide protection against the solvent.

Skin protection Wear appropriate gloves, lab coat, or other protective overgarment if skin contact

is likely. Base the choice of skin protection on the job activity, potential for skin

contact and solven ts and reagents in use.

Eye/face protection Wear safety glasses with side shields, chemical splash goggles, or full face shield,

if necessary. Base the choice of protection on the job activity and potential for

contact with eyes or face. An emerge ncy eye wash station should be available.

Environmental Exposure

Controls Avoid release to the environment and operate within closed systems wherever

practicable. Air and liquid emissions should be directed to appropriate pollution

control devices. I n case of spill, do not release to drains. Implement appropriate

and effective emergency response procedures to prevent release or spread of

contamination and to prevent inadvertent contact by personnel.Revision date: 30 June 2011

Version: 2 .0 Page 6 of 11 SECTION 8

- EXPOSURE CONTROLS/PERSONAL PROTECTION ...continued

Other protective

measures Wash hands in the event of contact with this substance, especially before eating,

drinking or smoking. Protective equipment is not to be worn outside the work area

(e.g., in common areas or out

- of

- doors). Decontaminate all protective equipment

following use.

SECTION 9

- PHYSICAL AND CHEMICAL PROPERTIES

Information on basic

physical and chemical

properties

Appearance

Color

Odor

Odor threshold

pH

Melting point/freezing

point

Initial boiling point and

boiling range

Flash point

Evaporation rate

Flammability (solid, gas)

Upper/lower

flammability or explosive

limits

Vapor pressure

Vapor density

Relative density

Water solubility

Solvent solubility

Partition coefficient

( n

- octanol/water )

Auto

- ignition

temperatureRevision date: 30 June 2011

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- PHYSICAL AND CHEMICAL PROPERTIES ...continued

Decomposition

temperature

Viscosity

Explosive properties

Oxidizing properties

Other information

Molecular weight

Molecular formula

SECTION 10

- STABILITY AND REACTIVITY

Reactivity No information identified.

Chemical stability No information identified.

Possibility of hazardous

reactions Not expected to occur.

Conditions to avoid No information identified.

Incompatible materials No information identified.

Hazardous decomposition

products No information identified.

SECTION 11

- TOXICOLOGICAL INFORMATION

Information on toxicological

effects

Route of entry May be absorbed by inhalation, skin contact and ingestion.

Acute toxicity

Compound Type Route Species Dose

-- -- -- --

LC 50 Inhalation Rat >2.19 mg/L

LD 50 Oral Rat > 5000 mg/kg

LD 50 Dermal Rabbit > 5000 mg/kgRevision date: 30 June 2011

Version: 2 .0 Page 8 of 11 SECTION 11

- TOXICOLOGICAL INFORMATION ...continued

Irritation/Corrosion This has not been tested. is a dermal and eye irritant in rabbits.

Sensitization This has not been tested. Skin sen sitization was observed for in

a local lymph node assay (LLNA) in mice.

STOT

- single exposure No studies identified.

STOT

- repeated

exposure/Repeat

- dose

toxicity No studies identified.

Reproductive toxicity No studies identified.

Developmental toxicity No studies identified.

Genotoxicity was negative in the Ames bacterial cell mutagenicity assay.

Carcinogenicity No studies identified. This substance is not listed by NTP, IARC, ACGIH or

OSHA as a carcinogen.

Aspiration hazard No data available.

Human health data See "Section 2

- Other Hazards"

Additional information not fully tested.

SECTION 12

- ECOLOGICAL INFORMATION

Toxicity

Compound Type Species Concentration

-- -- --

-- -- --

Additional toxicity

information No data available.

Persistence and

Degradability No data available.

Bioaccumulative potential No data available.

Mobility in soil No data available.

Results of PBT and vPvB

assessment No data available.Revision date: 30 June 2011

Version: 2 .0 Page 9 of 11 SECTION 12

- ECOLOGICAL INFORMATION ...continued

Other adverse effects No data available.

Note The environmental characteristics of this have not been fully investigated.

Releases to the environment should be avoided.

SECTION 13

- DISPOSAL CONSIDERATIONS

Waste treatment methods Used product should be disposed of according to local, s tate, and federal

regulations. Do not send down the drain or flush down the toilet. All wastes

containing the material should be prope rl y labeled. Dispose of wastes in

accordance to prescribed federal, state, and local guidelines, e.g., appropriately

permitted chemical waste incinerator. Rinse waters resulting from spill cleanups

should be discharged in an environmentally safe manner, e.g. , appropriately

permitted municipal or on- site wastewater treatment facility.

SECTION 14

- TRANSPORT INFORMATION

Transport Based on the available data, this is not regulated as a hazardous material/

dangerous good under EU ADR/RID, US DOT, Canada TDG, IATA, or IMDG.

UN number None assigned.

UN proper shipping name None assigned.

Transport hazard classes

and packing group None assigned.

Environmental hazards Based on the available data, this product/mixture is not regulated as an

environmental hazard or a marine pollutant.

Special precautions for

users not fully tested

- avoid exposure.

Transport in bulk according

to Annex II of

MARPOL73/78 and the IBC

Code Not applicable.

SECTION 15

- REGULATORY INFORMATION

Safety, health and

environmental

regulations/legisl ation

specific for the substance or

mixture This SDS complies with the requirements under US, EU and GHS (EU CLP

- Regulation EC No 1272/2008) guidelines.Revision date: 30 June 2011

Version: 2 .0 Page 10 of 11 SECTION 15

- REGULATORY INFORMATION ...continued

Chemical safety assessment Not conducted.

OSHA Hazardous Yes. May cause allergic skin reaction. not fully tested.

WHMIS classification Not classified. This product has been classified in accordance with the hazard

criteria of the Controlled Products Regulations and the SDS con tains all of the

information required by those regulations.

TSCA status This is not listed on the TSCA inventory.

SARA section 313 Not listed.

California proposition 65 Not listed.

SECTION 16

- OTHER INFORMATION

Full text of R phrases and

EU Classifications R43

- May cause sensitization by skin contact. not yet fully tested.

Full text of H phrases, P

phrases and GHS

classification SS1

- Skin sensitizer Category 1. H317

- May cause an allergic skin reaction.

not yet fully tested.

Sources of data Information from published literature and internal company data.

Abbreviations ACGIH

- American Conference of Governmental Industrial Hygienists ADR/RID

- European Agreement Concerning the International Carriage of Dangerous Goods

by Road/Rail AIHA

- American Industrial Hygiene Association CAS# - Chemical

Abstract Services Number DNE L

- Derived No Effect Level DOT

- Department of

Transportation EINECS

- European Inventory of New and Existing Chemical

Substances ELINCS

- European List of Notified Chemical Substances EU

- European Union GHS - Globally Harmonized System of Classification and

Labelling of Chemicals IARC

- International Agency for Research on Cancer

IDLH

- Immediately Dangerous to Life or Health IATA

- International Air

Transport Association IMDG

- International Maritime Dangerous Goods LOEL

-

Lowest Observed Effect Level L OAEL

- Lowest Observed Adverse Effect Level

NIOSH

- The National Institute for Occupational Safety and Health NOEL

- No

Observed Effect Level NOAEL

- No Observed Adverse Effect Level NTP

- National Toxicology Program OEL

- Occupational Exposure Limit OSHA -

Occupational Safety and Health Administration PBT

- Persistent, Bioaccumulative

and Toxic PNEC

- Predicted No Effect Concentration SARA

- Superfund

Amendments and Reauthorization Act STEL - Short Term Exposure LimitRevision date: 30 June 2011

Version: 2 .0 Page 11 of 11 SECTION 16

- OTHER INFORMATION ...continued

Abbreviations ...continued TDG

- Transport Dangerous Goods TSCA

- Toxic Substances Control Act TWA

- Time Weighted Average WHMIS

- Workplace Hazardous Materials Information

System

Revisions This is the first version of this SDS.

Disclaimer The above information is based on data available to us and is believed to be

correct. Since the information may be applied under conditions beyond our control

and with which we may be unfamiliar, we do not assume any responsibility for the

resul ts of its use and all persons receiving it must make their own determination of

the effects, properties and protections which pertain to their particular conditions.

No representation, warranty, or guarantee, express or implied (including a

warranty of fit ness or merchantability for a particular purpose), is made with

respect to the materials, the accuracy of this information, the results to be obtained

from the use thereof, or the hazards connected with the use of the material.

Caution should be used in th e handling and use of the material because i t is a

pharmaceutical product. The above information is offered in good faith and with

t he belief that it is accurate. As of the date of issuance, we are providing all

information relevant to the foresee able hand ling of the material. However, in the

event of an adverse incident associated with this product, this Safety Data Sheet is

not, and is not intended to be, a substitute for consultation with appropriately

trained personnel.