IB 

Union Calendar No. 419 

118TH CONGRESS 

2D SESSION H. R. 7406 

[Report No. 118–504] 

To amend the Public Health Service Act to authorize the Secretary of Health 

and Human Services to carry out a program of research, training, 

and investigation related to Down syndrome, and for other purposes. 

IN THE HOUSE OF REPRESENTATIVES 

FEBRUARY 16, 2024 

Mrs. RODGERS of Washington (for herself, Ms. DEGETTE, Mr. COLE, Ms. 

NORTON, Ms. DELAURO, and Mr. STAUBER) introduced the following 

bill; which was referred to the Committee on Energy and Commerce 

MAY 14, 2024 

Additional sponsor: Mr. TRONE

MAY 14, 2024 

Reported with an amendment, committed to the Committee of the Whole 

House on the State of the Union, and ordered to be printed 

[Strike out all after the enacting clause and insert the part printed in italic] 

[For text of introduced bill, see copy of bill as introduced on February 16, 2024] 


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•HR 7406 RH

A BILL 

To amend the Public Health Service Act to authorize the 

Secretary of Health and Human Services to carry out 

a program of research, training, and investigation related 

to Down syndrome, and for other purposes. 


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•HR 7406 RH

1 Be it enacted by the Senate and House of Representa2 tives of the United States of America in Congress assembled, 

3 SECTION 1. SHORT TITLE. 

4 This Act may be cited as the ‘‘DeOndra Dixon IN5 CLUDE Project Act of 2024’’. 

6 SEC. 2. DOWN SYNDROME RESEARCH. 

7 Part A of title IV of the Public Health Service Act 

8 (42 U.S.C. 281 et seq.) is amended by adding at the end 

9 the following: 

10 ‘‘SEC. 404P. DOWN SYNDROME RESEARCH. 

11 ‘‘(a) IN GENERAL.—The Secretary, acting through the 

12 Office of the Director of NIH, and in consultation with 

13 other Federal agencies and partners, shall carry out a pro14 gram of research, training, and investigation related to 

15 Down syndrome to be known as the ‘INvestigation of Co16 occurring conditions across the Lifespan to Understand 

17 Down syndromE Project’ or the ‘INCLUDE Project’. 

18 ‘‘(b) PROGRAM ELEMENTS.—The program under sub19 section (a) shall include research, training, and investiga20 tion related to— 

21 ‘‘(1) high-risk, high reward basic science studies 

22 of the effects of chromosome 21 on human development 

23 and health; 

24 ‘‘(2) assembling and maintaining a large study 

25 population of individuals with Down syndrome; 


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•HR 7406 RH

1 ‘‘(3) expanding the number of clinical trials that 

2 are inclusive of, or expressly for, individuals with 

3 Down syndrome, including novel biomedical and 

4 pharmacological interventions and other therapies de5 signed to promote or enhance activities of daily liv6 ing; 

7 ‘‘(4) the biological mechanisms in individuals 

8 with Down syndrome responsible for structural and 

9 functional anomalies in cells, tissues, and organs, cog10 nitive and behavioral dysfunction, and stunted 

11 growth; 

12 ‘‘(5) the identification of biomarkers for the de13 tection of risk factors, diagnosis, and customized 

14 interventions and treatments for conditions co-occur15 ring with Down syndrome; 

16 ‘‘(6) why several co-occurring conditions, such as 

17 Alzheimer’s Disease and autoimmunity, are prevalent 

18 in individuals with Down syndrome and how such 

19 conditions can be treated concurrently with Down 

20 syndrome; and 

21 ‘‘(7) improving the quality of life of individuals 

22 with Down syndrome and their families. 

23 ‘‘(c) COORDINATION; PRIORITIZING NONDUPLICATIVE

24 RESEARCH.—The Secretary shall ensure that— 


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•HR 7406 RH

1 ‘‘(1) the programs and activities of the institutes, 

2 centers, agencies, and offices of the National Institutes 

3 of Health relating to Down Syndrome and co-occur4 ring conditions are coordinated, including through 

5 the Division of Program Coordination, Planning, and 

6 Strategic Initiatives under sections 402(b)(7) and 

7 402A(c); and 

8 ‘‘(2) such institutes, centers, agencies, and offices 

9 prioritize, as appropriate, Down syndrome research 

10 that does not duplicate existing research activities of 

11 the National Institutes of Health. 

12 ‘‘(d) TECHNICAL ASSISTANCE.—The Secretary shall 

13 provide technical assistance to grantees and other involved 

14 entities, as appropriate, for carrying out activities pursu15 ant to this section. 

16 ‘‘(e) BIENNIAL REPORTS TO CONGRESS.— 

17 ‘‘(1) IN GENERAL.—The Secretary shall submit, 

18 on a biennial basis, to the Committee on Energy and 

19 Commerce and the Subcommittee on Labor, Health 

20 and Human Services, Education of the Committee on 

21 Appropriations of the House of Representatives and 

22 the Committee on Health, Education, Labor, and 

23 Pensions and the Subcommittee on Labor, Health and 

24 Human Services, Education, and Related Agencies of 

25 the Committee on Appropriations of the Senate, a reVerDate Sep 11 2014 01:45 May 15, 2024 Jkt 049200 PO 00000 Frm 00005 Fmt 6652 Sfmt 6203 E:\BILLS\H7406.RH H7406

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•HR 7406 RH

1 port that catalogs the research conducted or supported 

2 under this section. 

3 ‘‘(2) CONTENTS.—Each report under paragraph 

4 (1) shall include— 

5 ‘‘(A) identification of the institute, center, 

6 agency, office, or entity involved; 

7 ‘‘(B) a statement of whether the research is 

8 or was being carried out directly by the institute, 

9 center, agency, office, or entity or by multiple in10 stitutes, centers, agencies, offices, or entities; and 

11 ‘‘(C) identification of any resulting real 

12 world evidence that is or may be used for clin13 ical research and medical care for patients with 

14 Down syndrome. 

15 ‘‘(f) AUTHORIZATION OF APPROPRIATIONS.— 

16 ‘‘(1) IN GENERAL.—To carry out this section, 

17 there is authorized to be appropriated $90,000,000 for 

18 each of fiscal years 2025 through 2029. 

19 ‘‘(2) SUPPLEMENT, NOT SUPPLANT.—Funds ap20 propriated to carry out this section shall be used to 

21 supplement, not supplant, other funds allocated by the 

22 National Institutes of Health for research and other 

23 activities relating to Down syndrome.’’. 


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Union Calendar No. 419 

118TH CONGRESS 

2D SESSION H. R. 7406 

[Report No. 118–504] 

A BILL 

To amend the Public Health Service Act to authorother purposes. investigation related to Down syndrome, and for to carry out a program of research, training, and ize the Secretary of Health and Human Services 

MAY 14, 2024 

Reported with an amendment, committed to the Comand ordered to be printed mittee of the Whole House on the State of the Union, 


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