EX-4.1



 Exhibit 4.1 
  






 
 ZQ|CERT#|COY|CLS|RGSTRY|ACCT#|TRANSTYPE|RUN#|TRANS# 
COMMON STOCK 
PAR VALUE $.001 
Certificate 
Number 
ZQ00000000 
COMMON STOCK 
THIS CERTIFICATE IS TRANSFERABLE IN CANTON, MA, JERSEY CITY, NJ AND COLLEGE STATION, TX 
Shares

**000000****************** 
***000000***************** 
****000000**************** 
*****000000*************** 
******000000************** 
G1 
THERAPEUTICS 
G1 THERAPEUTICS, INC. 
INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE 
THIS CERTIFIES THAT 
** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample *** Mr. Alexander David
Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample ****
Mr. Alexander David Sample **** Mr. Alexander David Sample ***** Mr. Alexander David Sample *** Mr. Alexander David Sample **** Alexander David Sample **** Alexander David Sample **** Alexander David Sample **** Alexander David
Sample **** Alexander David Sample **** Alexander David Sample **** Alexander David Sample **** Alexander David Sample **** Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander
David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Alexander David Sample **** Alexander David Sample **** Alexander David Sample **** Alexander David Sample **** Mr. Alexander David Sample ****
Alexander David Sample **** Alexander David Sample **** Alexander David Sample **** Mr. Alexander David Sample **** Alexander David Sample **** Mr. Alexander David Sample *** Alexander David Sample **** Mr. Alexander David Sample ****
Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David
Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Sample **** Mr. Sample 
CUSIP 3621LQ 10 9 
SEE REVERSE FOR CERTAIN DEFINITIONS 
is the owner of 
**000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares*** 
*Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares** **000000**Shares****000000**Shares****000000**
Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**S 
FULLY-PAID AND NON-ASSESSABLE SHARES OF COMMON STOCK OF 
G1 Therapeutics, Inc. (hereinafter called the “Company”), transferable on the
books of the Company in person or by duly authorized attorney, upon surrender of this Certificate properly endorsed. This Certificate and the shares represented hereby, are issued and shall be held subject to all of the provisions of the Articles of
Incorporation, as amended, and the By-Laws, as amended, of the Company (copies of which are on file with the Company and with the Transfer Agent), to all of which each holder, by acceptance hereof, assents.
This Certificate is not valid unless countersigned and registered by the Transfer Agent and Registrar. 
Witness the facsimile seal of the Company and the facsimile
signatures of its duly authorized officers. 
President 
Secretary 
G1 THERAPEUTICS, INC. 
SEAL 
2008 
DELAWARE 
DATED DD-MMM-YYYY 
COUNTERSIGNED AND REGISTERED: COMPUTERSHARE TRUST COMPANY, N.A. 
TRANSFER AGENT AND REGISTRAR,

By 
AUTHORIZED SIGNATURE 
1234567 
G1

THERAPEUTICS 
PO BOX 43004, Providence, RI 02940-3004 
MR A SAMPLE DESIGNATION (IF ANY) 
ADD 1 
ADD 2 
ADD 3 
ADD 4 
CUSIP XXXXXX XX X 
Holder ID XXXXXXXXXX 
Insurance Value 1,000,000.00 
Number of Shares 123456 DTC 12345678 123456789012345 
Certificate Numbers Num/No. Denom. Total

1234567890/1234567890 1 1 1 
1234567890/1234567890 2 2 2 
1234567890/1234567890 3 3 3 
1234567890/1234567890 4 4 4 
1234567890/1234567890 5 5 5 
1234567890/1234567890 6 6 6 
Total Transaction 7 







  
 G1
THERAPEUTICS, INC. 
 THE COMPANY WILL FURNISH WITHOUT CHARGE TO EACH SHAREHOLDER WHO SO REQUESTS, A SUMMARY OF THE POWERS, DESIGNATIONS, PREFERENCES AND
RELATIVE, PARTICIPATING, OPTIONAL OR OTHER SPECIAL RIGHTS OF EACH CLASS OF STOCK OF THE COMPANY AND THE QUALIFICATIONS, LIMITATIONS OR RESTRICTIONS OF SUCH PREFERENCES AND RIGHTS, AND THE VARIATIONS IN RIGHTS, PREFERENCES AND LIMITATIONS DETERMINED
FOR EACH SERIES, WHICH ARE FIXED BY THE ARTICLES OF INCORPORATION OF THE COMPANY, AS AMENDED, AND THE RESOLUTIONS OF THE BOARD OF DIRECTORS OF THE COMPANY, AND THE AUTHORITY OF THE BOARD OF DIRECTORS TO DETERMINE VARIATIONS FOR FUTURE SERIES. SUCH
REQUEST MAY BE MADE TO THE OFFICE OF THE SECRETARY OF THE COMPANY OR TO THE TRANSFER AGENT. THE BOARD OF DIRECTORS MAY REQUIRE THE OWNER OF A LOST OR DESTROYED STOCK CERTIFICATE, OR HIS LEGAL REPRESENTATIVES, TO GIVE THE COMPANY A BOND TO INDEMNIFY
IT AND ITS TRANSFER AGENTS AND REGISTRARS AGAINST ANY CLAIM THAT MAY BE MADE AGAINST THEM ON ACCOUNT OF THE ALLEGED LOSS OR DESTRUCTION OF ANY SUCH CERTIFICATE. 

 

															
	 The following abbreviations, when used in the inscription on the face of this certificate, shall be
construed as though they were written out in full according to applicable laws or regulations:

								
	 TEN COM	 	-	 	as tenants in common	 	UNIF GIFT MIN ACT	 	-	 	  
	 	Custodian	 	  

		 		 		 		 		 	(Cust)	 		 	(Minor)


									
	 TEN ENT	 	  -	 	as tenants by the entireties	 	under Uniform Gifts to Minors Act	 	  

		 		 		 		 	(State)


																	
	 JT TEN	 	    -	 	as joint tenants with right of survivorship	 	UNIF TRF MIN ACT	 	-	 	  
	 	Custodian (until age	 	  
	 	)
		 		 	and not as tenants in common	 		 		 	(Cust)	 		 		 	


							
		 	  
	 	under Uniform Transfers to Minors Act	 	  

		 	(Minor)	 		 	(State)
	 Additional abbreviations may also be used though not in the above list.	 		 		 	

 
 PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE   

			
	For value received,                  hereby sell, assign and transfer unto	  	 

  
  

(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING POSTAL ZIP CODE, OF ASSIGNEE) 
  

 
  

 
  

			
		
	 	 	Shares
	of the common stock represented by the within Certificate, and do hereby irrevocably constitute and appoint	 	
		
	 	 	Attorney
	to transfer the said stock on the books of the within-named Company with full power of substitution in the premises.	 	


 


									
	Dated:	 		 	  
	 	20	 	  



					
		
	Signature:	 	  

		
	Signature:	 	  

		 	Notice:	 	The signature to this assignment must correspond with the name as written upon the face of the certificate, in every particular, without alteration or enlargement, or any change
whatever.





	
	Signature(s) Guaranteed: Medallion Guarantee Stamp
	 
	THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (Banks, Stockbrokers, Savings and Loan
Associations and Credit Unions) WITH MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM, PURSUANT TO S.E.C. RULE 17Ad-15.