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OAR Box 1850 

Prepped by Ollie Stewart 

Document Number: 

76) IV-B-6 

Docket Number: 

A-90-07 

Printed 11/18/2008 11:09:28 AM Sheet 76 of 161 
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_ > 'a UNITED STATES ENVIRONMENTAL PROTECTION AGENCY '_t."l >

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SB; ANN ARBOR. MICHIGA N 48105 

OFFICE OF 

AIR ANO RADIATION 

MAY 2 5 1994 

MEMORANDUM EPA AIR bqcKjn 

SUBJECT: 

FROM: 

THRU: 

TO: 

Reference List of Selected Motor Vehicle 

Exhaust Inhalation Toxicology Studies 

fafalfilr* 

1 

Kent Helmer, Toxicologist 

Special Regulatory Projects Branch' 

Judith Gray, Senior Project Manager'JlJuJUy^^^^X^^^' 

Special Regulatory Projects Branch / /) 

Air Docket no. A-90-07 

Attached is a list of selected references to inhalation 

toxicology studies, in which test animals have been exposed to 

motor vehicle exhaust. Included are six studies of gasoline 

emission exposure and nine studies of diesel emission exposure. 

Attachment 
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Selected References to Motor Vehicle Emission 

Inhalation Toxicology Studies 

1) DIESEL EXHAUST: 

a) Brightwell, J., Fouillet, X., Cassano-Zoppi, A-L., 

Gatz, R., Duchosal, F. "Neoplastic and Functional Changes in 

Rodents After Chronic Inhalation of Engine Exhaust Emissions", 

in: Carcinogenic and Mutagenic Effects of Diesel Engine Exhaust. 

Developments in Toxicology and Environmental Science Series, Vol. 

13 (Ishinishi, N., Koizumi, A., McClellan, R.O., Stober, W., 

eds.) Elsevier Science Publishing Co., New York, NY. pp. 471-485, 

1986. 

b) Heinrich, U., Muhle, H., Takenaka, S., Ernst, H., 

Fuhst, R., Mohr, U., Pott, F., Stober, W. "Chronic Effects on the 

Respiratory Tract of Hamsters, Mice and Rats After Long-term 

Inhalation of High Concentrations of Filtered and Unfiltered 

Diesel Engine Emissions" J. Appl. Toxicol. 6: 383-395, 1986. 

c) Heinrich, U., Pott, F., Rittinghausen, S. "Comparison of 

Chronic Inhalation Effects in Rodents After Long-term Exposure to 

Either Coal Oven Flue Gas mixed with Pyrolized Pitch or Diesel 

Engine Exhaust", in: Carcinogenic and Mutagenic Effects of Diesel 

Engine Exhaust. Developments in Toxicology and Environmental 

Science Series, Vol. 13 (Ishinishi, N., Koizumi, A., McClellan 

R.O., Stober, W., eds.) Elsevier Science Publishing Co., New 

York, NY. pp. 441-457, 1986. 

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r 

d) Ishinishi, N., Kuwabara, N., Nagase, S., Suzuki, T, 

Ishiwata, S., Kohno, T. "Long-term Inhalation Studies on the 

Effects of Exhaust from Heavy and Light Duty Diesel Engines on 

F344 rats" in: Carcinogenic and Mutagenic Effects of Diesel 

Engine Exhaust. Developments in Toxicology and Environmental 

Science Series, Vol. 13 (Ishinishi, N., Koizumi, A., McClellan, 

R.O., Stober, W., eds.) Elsevier Science Publishing Co., New 

York, NY. pp. 329-348, 1986. 

e) Karagianes, R., Palmer, R., Busch, R. "Effects of 

Inhaled Diesel Emissions and Coal Dust in Rats" Am. Ind. Hyg. 

Assoc. J. 42: 382-391, 1981. 

f) Lewis, T., Green, F., Moorman, W., Burg, J., Lynch, D. 

"A Chronic Inhalation Toxicity Study of Diesel Engine Emissions 

and Coal Dust Alone and Combined", in: Carcinogenic and Mutagenic 

Effects of Diesel Engine Exhaust. Developments in Toxicology and 

Environmental Science Series, Vol. 13 (Ishinishi, N., Koizumi, 

A., McClellan , R.O., Stober, W., eds.) Elsevier Science 

Publishing Co., New York, NY. pp. 361-380, 1986. 
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g) Mauderly, J., Jones, R., McClellan, R., Henderson, R., 

Griffith, W. "Carcinogenicity of Diesel Exhaust Inhaled 

Chronically by Rats", in: Carcinogenic and Mutagenic Effects of 

Diesel Engine Exhaust. Developments in Toxicology and 

Environmental Science Series, Vol. 13 (Ishinishi, N., Koizumi, 

A., McClellan, R.O., Stober, W., eds.) Elsevier Science 

Publishing Co., New York, NY. pp. 397-409, 1986. 

h) Stober, W. "Experimental Induction of Tumors in 

Hamsters, Mice, and Rats After Long-term Inhalation of Filtered 

and Unfiltered Diesel Engine Exhaust" in: Carcinogenic and 

Mutagenic Effects of Diesel Engine Exhaust. Developments in 

Toxicology and Environmental Science Series, Vol. 13 (Ishinishi, 

N., Koizumi, A., McClellan, R.O., Stober, W., eds.) Elsevier 

Science Publishing Co., New York, NY. pp. 421-439, 1986. 

i) Wolff, R., Henderson, R., Snipes, M., Griffith, W., 

Mauderly, J., Cuddihy, R., McClellan, R. "Alterations in Particle 

Accumulation and Clearance in Lungs of Rats Chronically Exposed 

to Diesel Exhaust" Fun. Appl. Toxicol. 9:154-166, 1987. 

2) GASOLINE EXHAUST: 

a ) * Brightwell, J., Fouillet, X., Cassano-Zoppi, A-L., Gatz, R., 

Duchosal, F. "Neoplastic and Functional Changes in Rodents After 

Chronic Inhalation of Engine Exhaust Emissions", in: Carcinogenic 

and Mutagenic Effects of Diesel Engine Exhaust. Developments in 

Toxicology and Environmental Science Series, Vol. 13 (Ishinishi, 

N., Koizumi, A., McClellan, R.O., Stober, W., eds.) Elsevier 

Science Publishing Co., New York, NY. pp. 471-485, 1986. 

b ) * Heinrich, U., Pott, F., Rittinghausen, S. "Comparison of 

Chronic Inhalation Effects in Rodents After Long-term Exposure to 

Either Coal Oven Flue Gas mixed with Pyrolized Pitch or Diesel 

Engine Exhaust", in: Carcinogenic and Mutagenic Effects of Diesel 

Engine Exhaust. Developments in Toxicology and Environmental 

Science Series, Vol. 13 (Ishinishi, N., Koizumi, A., McClellan , 

R.O., Stober, W., eds.) Elsevier Science Publishing Co., New 

York, NY. pp. 441-457, 1986. 

c) Lewis, T., Moorman, W., "Pulmonary and Cardiovascular 

Physiology Studies During Exposure", in: Long-term Effects of Air 

Pollutants in Canine Species: Series no. 8. (Stara, J., 

Dungworth, L., Orthoefer, J., Tyler, W., eds.) California 

University (Davis), Environmental Protection Agency, EPA-600/8-

80-014 (NTIS# PB81-144875) July, 1980. 

d) Massad, E., Hilario, P., Saldiva, N., Saldiva, C , Caldeira, 

M., Cardoso, L., Morais, M., Calheiros, D., de Silva, R., Bohm, 

G., "Toxicity of Prolonged Exposure to Ethanol and Gasoline 

Autoengine Exhaust Gases" Eviron. Res. 40:479-486, 1986. 
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e) Pepelko, W., et al. , "Effect of 90 Days Exposure to 

Catalytically-treate d Automobile Exhaust in Rats" Environ. Res. 

19:91-101, 1979. 

f) Stara, J. , Busch, K., Hinners, R., Burkart, J. , "Study 

Overview, Rationale, Experiental esign, Experimental Facilities, 

and Exposure Atmospheres", in: Long-term Effects of Air 

Pollutants in Canine Species: Series no. 8. (Stara, J. , 

Dungworth, L., Orthoefer, J. , Tyler, W., eds.) California 

University (Davis), Environmental Protection Agency, EPA-600/8-

80-014 (NTIS# PB81-144875) July, 1980. 

* These papers include discussion of gasoline emission inhalatio n studies, as 

well as diesel .