### 1 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION **UNITED ST AT**  **ES ENVIRONMENT AL** **PROTECTION A GENCY** 

WASHINGTON, D.C. 20460



### PC Code : 288202 DP Barcode : D 421158 **MEMORANDUM DATE:**  January

12 , 2015 **SUBJECT:** Estimated Drinking Water Concentrations for C yp rodinil and its Metabolite

CGA
- 249287 for the New Use s of the Chemical on Certain Stone Fruits (Crop Group 12
- 12), Certain Tropical Fruits, Artichoke, Cucumber (Greenhouse Use), and Pomegranate (Postharvest Dip) **FROM:** José L
. Meléndez, Chemist

Environmental Risk Branch 5 Environmental Fate and Effects Division (7507P) **THROUGH:** Mah T. Shamim, Ph.D., Branch Chief

Environmental Risk Branch 5 Environmental Fate and Effects Division (7507P) **TO:** Erin Malone , Risk Manager Reviewer

Hop e Johnson , Product Manager #21 Cy nthia Giles
- Parker**,** Branch Chief Fungicide Branch Registration Division (7505P) **AND:** Thurston Morton, Chemist

Elissa Reaves , Branch Chief Risk Assessment Branch 4 Health Effects Division (7509P) This memo presents the Estimated Drinking Water Concentrations (EDWCs) for cy prodinil, an active ingredient of Vangard® 

### WG, SwitchTM 

### 62.5 G , and Inspire SuperTM Fungicides, and its metabolite CGA
- 249287 (as per the Metabolism Assessment Review Committee’s decision document (MARC)) , for the new u ses of the chemical on certain stone fruits (Crop Group 12
- 12), certain tropical fruits, artichoke, cucumber (greenhouse use), and pomegranate (postharvest dip)
. Based on a review of the use information, it was found that all the newly p roposed crops

### 2

have a similar or lower application rate than the maximum application rate of 0.47 lb a.i./A applied three times per ye ar, or 1.4 lb a.i./A/ye ar, previously modeled using the N ew York grapes scenario
. EDWCs for the new uses should be similar than those already calculated for grapes . Since previously modeled crops cover the new proposed crops, the results of the previous drinking waters assessment (DWA) can be used for the new uses ; a new DWA is not required. Inaddition, this DWA provides EDWCs from the new model PRZM
- GW , which had not been modeled in the past . **Appendix A**  provides the groundwater results obtained from PRZM
- GW. A previous DWA, dated November 8, 2010 (DP Barcode D382086), involved only the products Vangard® WG and Switch® 62.5G Fungicides and the request to apply a maximum of two times aerially

the product s to most of the crops , and chemigation application s for several of the crops. The DWA provides structures and nomenclature of cy prodinil and its metabolite CGA
- 249287 , as well as a summary o f environmental fate for the chemical
. Ina 2 011 DWA, a number of new uses were evaluated (DP Barcode D391853, dated November 4, 2011) , but it referred back to the 2 010 DWA for EDWCs
. The tier 2 aquatic models PRZM/EXAMS , and the model s SCI
- GROW and PRZM
- GW were used to obtain EDWCs in surface water and groundwater, respectivel y. The acute EDWC in surface water is 34.8 μg/Lf or the total residues of cy prodinil plus CGA
- 249287. The chronic EDWC in surface waters is 24.7 μg/L for the total residues of cy prodinil and CGA
- 249287. The cancer/chronic EDWC in surface waters is 16.4 μg/Lf or the total residues of cy prodinil and CGA
- 249287. All surface waters EDWCs were obtained using the New York grapes PRZM scenario. The PRZM
- GW generated EDWC for the use on grapes , using the FL citrus surrogate scenario were 2.05 μg/L for the total residues of cy prodinil and CGA
- 249287 (acute) and 1.80 μg/Lf or the total residues (chronic)
. For details on methods, characterization of results, uncertainties, etc. , please, refer to the previous DWAs
. **Table 1** provides a summary of the Tier 2 modeled drinking water concentrations. **Table 1.**  **M aximum**  **Estimated Drinking**  **Water Concentrations**  **for the**  **Use of**  **Cyprodinil (expressed as total residues of cyprodinil plus its degradate CGA** **- 249287)**  **DRINKING WATER SOURCE (MODEL USED)**  **USE (rate modeled per year** **) MAXIMUM ESTIMATED DRINKING WATER**  **CONCENTRATION (EDWC) ( ppb**  **)** Groundwater (PRZM
- GW) FL citrus 1 (1.4 lb a.i.) Acute 2.05 Chronic 1.80 Surface water (PRZM/EXAMS) NY grapes (1.4 lb a.i.) Acute 34.8 Chronic 24.7 Cancer/Chronic 16.4 1 Scenario wa s used as a surrogate and run with the maximum application rate for grapes. 

### Should it be required, additional refinements may be available. For example, regional PCAs and ty pical use rates may

be options to be used should it be requested b y HED. **Identification of specific data gaps** : The environmental fate data base for cy prodinil is considered substantially c omplete; there are no new data available for this assessment. There is uncertainty with the aqueous photol ys is study (MRID 43908422 )
. It was carried out with natural (unsterilized) water. Phototransformation of cy prodinil in the irradiated samples followed a biphasic pattern, with slow transformation at the beginning. The possibility o f microbial transformation is not ruled

### 3

out. F or modeling purposes, it was assumed that cy prodinil is stable to aqueous photol ys is, which is a conservative assumption. Since the Problem Formulation for Registration Review was issued in 2012 (DP Barcode D393800 ) , aerobic soil metabolism studies were submitted, which are currently

in review. **Use information:** Three end
-use products are involved in this DWA , as shown below
. One product contains onl y cy prodinil, while two of the products have another active ingredient :
 Vangard® WG Fungicide (EPA Reg. No. 100
- 828), containing 75.0% cy prodinil A
. I
. and 25.0% other ingredients  Switch® 62.5 G Fungicide (EPA Reg. No. 100
- 953) containing 37.5% cy prodinil A
. I
. , 25.0% fludioxonil A
. I
. and 37.5% other ingredients  Inspire SuperTM Fungicide (EPA Reg. No. 100
- 1317) containing 24.1% cy prodinil A
. I
. , 8.4% difenoconazole A .I. and 67.5% other ingredients **Table 2**  provides a summary o f the current and proposed use information for the pesticide cy prodinil only ( i.e. , the table does not include the other two active ingredients). It also shows which crops have been modeled in the past. Generally, no more than two sequential applications are allowed as part of a resistance management strategy (unless otherwise stated for a crop). The label requires a buffer zone to protect lakes, reservoirs, rivers, permanent streams, marshes or natural ponds, estuaries and commercial fish ponds. F or ground applications the buffer zone is 75 ft; meanwhile , for aerial applications the buffer zone is 150 ft. A vegetative filter strip should be allowed within 10 ft of aquatic areas. Furthermore, other measures of pre caution are required ( e.g. applications when gusts or sustained winds exceed 10 mph are not allowed). Several crops have been modeled in the past, using seasonal rates of 1.4 lb a.i./A/season
. These include CA almond, NY grape, CA fruit and MI cherry
. Additionally, other crops have been modeled using a seasonal rate of 1.3 lb a.i./A/season , which included OR snap bean, FL strawberry, MO melon, NC sweet potato, GA onion and PA tomato. The new uses involve similar rates: for the additional stone fruits the maximum seasonal rate is 1.4 lb a.i./A/season ; for the additional tropical fruits it is 1.3 lb a.i./A/season ; and for artichoke it is 1.32 lb a.i./A/season
. The new use on cucumber is for greenhouses, and the use on pomegranate is for before and after storage ; the uses on cucumber for greenhouses and pomegranate do not involve substantial exposure to wildlife. Since previously

modeled crops cover the new proposed crops, the results of the previous DWA can be used for the new uses. **Table 2**  **. S**  **ummary of**  **use inform** **ation for**  **cyprodinil, based**  **on Vangard**  **® WG**  **(EPA Reg.**  **No. 100**  **- 828),**  **Switch® 62.5G**  **(EPA Reg.**  **No. 100**  **- 953)**  **and Inspire**  **Super® (EPA**  **Reg. No.**  **1317) Fungicides.**  **C hanges**  **or new crops are shaded**  **blue . Scenarios that were previously m** **odeled are shaded y**  **ellow .**  **Use Max**  **S ingle**  **App Rate (lb a.i./A)**  **Number of**

**Apps at Max Rate**  **Annual App.**

**Rate (lb a.i./A** **/yr )**  **Min I**  **nterval**

**B etween**  **Apps . (days)**  **App**

**Method Pre**  **- H** **arvest**

**I nterval**  **(days)** Almond ( CA almond) 0.47 3 1.4 NS or 14 (1) G, A ***** 14

### 4

**Use Max**  **S ingle**  **App Rate (lb a.i./A)**  **Number of**

**Apps at Max Rate**  **Annual App.**

**Rate (lb a.i./A** **/yr )**  **Min I**  **nterval**

**B etween**  **Apps . (days)**  **App**

**Method Pre**  **- H** **arvest**

**I nterval**  **(days)** Pistachio 0.33 4 1.3 14 G, A ***** 7 Tree Nuts (beech, Brazil nut, butternut, cashew, chestnut, chinquapin, filbert (hazelnut), hickory nut, macadamia nut, pecan, walnut (black and English)) 0.47 3 1.4 NS (2) G, A ***** 14
Citrus (lemon, lime) 0.33 1 0.33 N/A G 0 Grapes (NY Grape ) (including cultivars, varieties, and/or hybrids of these; Amur river grape, hardy kiwifruit, maypop, schisandra berry; and muscadines, gooseberry for I nspire SuperTM only) 0.47 3 1.4 7 G, A ***** (5) 7 ;

(14 days for Inspire Super® only) Kiwi 0.47 2 0.94 7 G, A ***** 0 Pome Fruits ( CA fruit) (apples, azarole, crabapples, loquat, mayhaw, medlar, pears, Asian pear, quince, Chinese quince, Japanese quince, tejocote and cultivars, varieties and/or hybrids of these) 0.23 6 1.4 7 G, A ***** (6) 0

Stone Fruits , Crop Group 12
- 12 (MI Cherry) (apricot, tart cherries, nectarines, peaches, plums, prunes , plumcot, Japanese apricot, capulin, black cherry, Nanking cherry, sweet cherry, Chinese jujube, beach plum, Canada plum, cherry plum, American plum, Chickasaw plum, Damson plum, Japa nese plum, Klamath plum, prune plum, sloe, including all cultivars and/ or hybrids of these) 0.33**,

---------- 0.23 ** ,

---------- 0.47 ** in CA ~5,

------- 6,

------- up to 2 in CA (plus 2 apps at 0.23 lb/A) 1.4 N/S (3) G, A ***** 2

Tropical Fruits (Dragon fruit , lychee, longan, Spanish lime, rambutan, pulasan , avocado, black sapote, canistel, mamey sapote, mango, papaya, sapodilla , star apple, acerola, feijoa, guava, jaboticaba, passionfruit, starfruit, wax jambu) 0.33 4 1.3 7 G, A ***** (5 ) 0
Beans (dried and succulent, except cow peas) ( OR Snap Bean) (garbanzo bean or chickpea, grain lupin bean, sweet lupin bean, white lupin bean, white sweet lupin bean, kidney bean, lima bean, mung bean, navy bean, pinto bean, snap bean, wax bean, fava bean, asparagus bean and blackeyed pea) 0.33 4 1.3 7 G, A ***** , C 7

Straw berries (FL Strawberry) (including cultivars, varieties, and/or hybrids of these, bearberry, bildberry, cloudberry, mountries, partridgeberry) 0.47 3 at 0.43 1.3 7 G, A ***** , C (5) 0
Berries: (including all cultivars and/ or hybrids of these) Bushberries (aronia berry, black currant, blueberry high and low bush, Buffalo currant, Chilean guava, currant, edible honeysuckle, elderberry, European barberry, gooseberry, highbush cranberry, huckleberry, jostaberry, juneberry (Saskatoon berry), lingonberry, native currant, red currant, salal, sea buckthorn) Caneberries (blackberry, loganberry, red and black raspberry, wild raspberry) 0.33 4 1.3 7 G, A ***** (5 ) 0

### 5

**Use Max**  **S ingle**  **App Rate (lb a.i./A)**  **Number of**

**Apps at Max Rate**  **Annual App.**

**Rate (lb a.i./A** **/yr )**  **Min I**  **nterval**

**B etween**  **Apps . (days)**  **App**

**Method Pre**  **- H** **arvest**

**I nterval**  **(days)** Brassica (cole) leafy vegetables (broccoli, Chinese broccoli, broccoli raab, Brussel sprouts, cabbage, Chinese cabbage, cauliflower, cavalo broccolo, collards, kale, kohlrabi, mizuna, mustard greens, mustard spinach, rape greens and turnip greens) 0.33 4 1.3 7 G, A ***** , C 7
Cucurbit Crops (MO Melon) ( cantaloupe, cucumber***** , guourds, honeydew, muskmelon, watermelon, chayote, Chinese waxgourd, Momordica spp
. (bitter melon, balsam apple) , pumpkin, squash and zucchini ) 0.33 4 1.3 7 G, A ***** , C 1
Herbs, Dried and Fresh (angelica, balm, basil, borage, burnet, camomille, catnip, dried chervil leaves, chive, clary, coriander leaves {cilantro} , costmary, culantro leaves, curry leaves, dillweed, horehound, hyssop, lavender, lemongrass, lovage leaves, marigold, marjoram, nasturtium, dried parsley leaves, pennyroyal, rosemary, rue, sage, summer and winter savory, sweet bay, tansy, tarragon, thyme, wintergreen, woodruff and wormwood) 0.33 4 1.3 7 G, A ***** , C 7

Leafy Vegetables (except brassica) (head and leaf of lettuce, amaranth, arugula, chervil, edible chrysanthemum, corn salad, cress, dandelion, dock, escarole endive (escarole), New Zealand spinach, orach, parsley, purslane, radicchio, spinach, spinach vine) Leafy Petioles ( Cardoon celery; celery; Chinese celery; celtuce; Florence fennel; rhubarb; Swiss chard) 0.33 4 1.3 7 G, A ***** , C (7) 0

Leaves of Root and Tuber Vegetables (NC Sweet Potato ) (carrot, garden beet, sugar beet, edible burdock, cassava, celeriac, chicory, dasheen, parsnip, Oriental radish, rutabaga, black salsify, Spanish salsify, sweet potato, tanier, turnip rooted chervil, true yam) 0.33 4 1.3 (4 ) 7 G, A ***** , C 7

Root Vegetables (except sugar beet) (edible burdock, carrot, celeriac, chicory, garden beet, ginseng, horseradish, parsnip, Oriental radish, rutabaga, black salsify, Spanish salsify, skirret, turnip, turnip root parsley, turnip rooted chervil) 0.33 4 1.3 (4 ) 7 G, A ***** , C 7
Bulb Onion ( GA Onion) (Chinese onion, dry bulb onion, daylily bulb, Fritillaria bulb, garlic, great headed garlic, lily bulb, pearl onion, potato onion, serpent garlic, shallot) Green Onion (Beltsville bunching onion, Chinese chive fresh leaves, fresh chive leaves, Fritillaria leaves, fresh onion, green onion, Hosta elegans, Kurrat, lady’s leek, leek, macrostem onion, shallot fresh leaves, tree tops onion, Welsh onion tops, wild leek, wild onion) Onions Grown for Seed 0.47 3 at 0.43 1.3 7 G, A ***** , C (7) 7

### 6

**Use Max**  **S ingle**  **App Rate (lb a.i./A)**  **Number of**

**Apps at Max Rate**  **Annual App.**

**Rate (lb a.i./A** **/yr )**  **Min I**  **nterval**

**B etween**  **Apps . (days)**  **App**

**Method Pre**  **- H** **arvest**

**I nterval**  **(days)** Tomatoes and Fruiting Vegetables , Crop Group 8
- 10 (PA Tomato ) (African eggplant, bush tomato, bell pepper, cocona, currant tomato, eggplant, garden huckleberry, Goji berry, groundcherry, Martynia, naranjilla, okra, pea eggplant, pepino, bell pepper, nonbell pepper, Roselle, scarlet eggplant, sunberry, tomatillo, tomato, tree tomato) 0.33 4 1.3 7 G, A ***** , C 0

Artichoke 0.328 4 1.32 14 G, A**+** , C 3 Watercress 0.33 4 1.3 7 G, C 0 Pomegranate (postharvest dip) ****** ***** 19.2 oz Switch 62.5WG (0.45 lb a.i.)/100 gal water 2 N/A Once before and after storage In line

dip/ drench; dip for about 30 seconds & drain Post
harvest

G = ground; A ***** = Aerial (maximum of two aerial applications allowed); A**+** = All aerial applications are allowed ( i.e. , no restrictions in the number of aerial applications for artichoke); C = Chemigation ; NS = Not specified. (1) For Vangard® WG one application at 5
- 10% bloom, 50
- 1 00% bloom and at petal fall. F or Inspire Super® the minimum retreatment interval is 14 days and the maximum single application rate is 0.33 lb a.i./A. (2 ) Apply when conditions are conducive to disease. It is noted that the supplemental labels for Switch® 62.5 W G and Inspire Super® do not have this crop group. (3 ) One application at bloom stage, second application at full bloom, in CA, two applications during the preharvest period. (4) For radish, only 2 applications per crop and 4 applications per year. (5) The supplemental label fo r Switch® 62.5 W G indicates that only one aerial application is allowed, and only in CA. Otherwise, only ground applications are allowed for the product. (6) This crop group not included in the supplemental label for Switch® 62 .5G. (7) The supplemental label for Inspire SuperTM does not have these crop groups. *For cucumbers, applications in greenhouse are allowed, at 0.46 fl oz/1000 sq ft (no mo re than 50% of the sprays per crop). Applications in greenhouse are not assessed. **T he label for Inspire Super® allows applications at 0.33 lb a.i./A. The label for Vangard® allows up to two applications at 0.47 lb a.i./A in CA plus two applications at 0.23 lb a.i./A. B oth labels allow up to two aerial applications. ***T his use, to c ontrol Botrytis fruit rot and Gray mold, is not assessed since it does not involve substantial exposure to wildlife.

### 7

**Appendix A . Tier 1 EDWCs**  **for Groundwater**  **- PRZM** **- GW**  **PRZM -**  **GW v.1.07** Summary The PRZM
- GW generated EDWC for the use on grapes, using the FL citrus scenario were 2.05 μg/L for the total residues of cy prodinil and CGA
- 249287 (acute) and 1.80 μg/L for the total residues (chronic). Conceptual Model **Figure A** **- 1**  depicts the general groundwater scenario concept for estimating pesticide concentrations in drinking water as implemented in PRZM
- GW. This conceptual model is based on a rural drinking water well beneath an agricultural field (a high pesticide use area) drawing from an unconfined, high water
-table aquifer.

**Figure A** **- 1.**  **General Ground** **water Scenario**  **Concept for**  **Estimating Pesticide**  **Concentrations in**  **Drinking Water**  **as Im** **plemented in**  **PRZM -**  **GW;** The black line through the soil profile represents the decline in degradation with respect to the depth. The depth of the well is site specific ( i. e. , scenario specific). The well extends into a shallow unconfined aquifer and has a well
- screen 1 

### that starts at the top and extends down into the aquifer. The length of the well
- screen represents the region of the aquifer where drinking water is collected
. The well
- screen length is well
- specific and can be adjusted. Processes included in the conceptual model that influence pesticide transport through the soil profile include water flow, chemical specific dissipation and transportation parameters ( i.e. , de gradation and sorption), and crop specific factors, including transpiration, pesticide interception and management practices.

1 A well screen is a filtering device that allows groundwater from unconsolidated and semi
- consolidated aquifers to enter the well while at the same time keeping the majority of sand and gravel out of the well.

### 8

The following is a brief description of the PRZM
- GW model. M ore information is available at http://www.epa.gov/oppefed1/models/water/index.htm#przm_gw (accessed 12/02/2014). Tier 1 groundwater estimated drinking water concentrations (EDWCs) for a chemical, resulting from its use for bare ground pre - plant applications were derived with PRZM - GW (Pesticide Root Zone Model for Groundwater, version 1.07, March 6, 2014), using the G W- GUI (Graphical User Interface, version 1.07, March 6, 2014). PRZM - GW is a one - dimensional, finite - difference model that estimates the concentrations of pesticides in groundwater. It accounts for pesticide fate in the crop root zone by simulating pesticide transport and degradation through the soil profile after a pesticide is applied to an agricultural field. PRZM - GW permits the assessment of multiple years of pesticide application (up to 100 years) on a single site. Six standard scenarios, each repres enting a different region known to be vulnerable to groundwater contaminations, are available for use with PRZM - GW for risk assessment purposes. I n PRZM - GW simulations, each of these standard scenarios was used. PRZM - GW output values represent pesticide concentrations in a vulnerable groundwater supply that is located directly beneath a rural agricultural field. 

### Input Parameters for PRZM
- GW and Results Calculation of the application rates is explained in **Table A -**  **1**
. **Table A -**  **1 .**  **Calculation of application rates for modeling of cyprodinil and its metabolite for**  **the use on grapes Chemical Species**  **% Maximum in Aerobic Soil Study Application Rate**  **(lb a.i./A) Molecular** 

**Ratio Modeled Application Rate** 

**(lb a.i./A) Observed** * **Normalized** Cy prodinil 100% 89.5% 0.421 1 **0.421** CGA
- 249287 11.7% 10.5% 0.0492 0.662 0.0327**  Total 111.7% 100% 0.47 The shaded and bolded area provides the results used in modeling. * Observed maximum values for parent and CGA 249287 in the aerobic soil metabolism studies ** CGA
- 249287 to cyprodinil molecular ratio = 149.20/ 225.29 

### For input parameters used in this model, refer to **Table A -** **2**
. **Table A** **- 2**  **. Cyprodinil**  **PRZM -**  **GW Input**  **Pa rameters**  **for modeling**  **applications of**  **the chemical**  **on grapes**  **PARAMETER (units) VALUE**  **1 SOURCE**  **COMMENT**

**Application date (day/m** **onth)** 30
- 05 Label. App lication s are set to occur close to date of maturation. Delmarva emergence 10
- 04, crop maturation 30
-

05, harvest 15
- 06 01
- 06 FL citrus crop emergence 01
- 01, crop maturation 01
- 02, harvest 31
- 12 21
- 04 FL potatoes emergence 15
- 02, crop maturation 01
- 05, harvest 01
- 06 01
- 08 GA coast emergence 01
- 05, crop maturation 01
- 08, harvest 01
- 10 01
- 08 NC coast emergence 15
- 05, crop maturation 01
- 08, harvest 01
- 11

### 9 **PARAMETER (units) VALUE**  **1 SOURCE**  **COMMENT** 21
- 07 WI sand emergence 01
- 05, crop maturation 21
- 07, harvest 20
- 10 **Maximum Application Rate (kg a.i./ha)**  0.472 Label Maximum application rate is 0.421 lb a.i./A x 3 applications at 7 day intervals. See **Table A -**  **1**
. **Number of Applications per Year**  3 **Retreatm ent Intervals**  **(days)** 7 **Chemical Application Me** **thod (CAM)** 2 Label Foliar **Incorporation Depth (cm )**  0
--- **Air diffusion coefficient (cm** **2 /day)**  0 .0 N/A Assuming no volatilization. **Vaporization enthalpy (kcal/mol)**  0 .0 N/A Assuming no volatilization. **Henry’s Law Constant (**  **atm -**  **m 3** **/m ol)**  0 .0 N/A Assuming no volatilization. **Partition Coefficient (K** **OC ; m** **L/g OC** **)** 1,745 437090
- 47 Sorption is correlated with OC. Mean KOC value among four values ranging from 1550 to 2030 ml/g. **Aerobic Soil Metabolism Half**  **- life (days)**  32.4 4 3908425, 43908426, 43709045, 43709046 Represents the 90 th percentile of the upper

confidence bound on the mean of four half
- life values: 39, 46 days at 20°C (corrected to 28, 33 days at 25°C), and 22, 31 days at 25°C ; mean = 28.5 days; std. dev. = 4.80 days **Hydrol ysis Half** 

**- life (days)**  0 437090
- 44 Stable at pH 5, 7 and 9. 1 Parameters are selected as per “Guidance for Selecting Input Parameters for Modeling Pesticide Concentrations in Groundwater Using the Pesticide Root Zone Model” v.1.0, dated October 15, 2012. 

### Results are provided in **Table A -** **3**
. **Table A** **- 3** 
. **Cyprodinil Estimated**  **Drinking Water**  **Concentrations (EDWCs)**  **resulting from**  **the use of the chemical**  **on grapes**  **Crop/Scenario Highest Daily**  **Value (μg/L)**  **Post Breakthrough Average**  **(μg/L) Average Sim** **ulation**

**Breakthrough Time (days)**  Grape s/Tier I Delmarva 1 9.28 x 10 - 5 8.5 x 10 - 5 22054 Grape s/Tier I FL citrus 1 0.0276 0.0269 18210 Grape s/Tier I FL potatoes 1 6.12 x 10 - 12 Incomplete 2 Incomplete 2 Grapes/Tier I GA coast 1 2.47 x 10 - 5 2.28 x 10 - 5 30062 Grapes/Tier I NC coast 1 2.26 x 10 - 5 2.08 x 10 - 5 18381 Grapes/Tier I WI sand 1 0.00317 0.00293 25728 1 This scenario was run with an extended weather file. 2 Incomplete despite running an extended weather file. t t t s

n input n    1 2 90 1 / , ( )

### 10

Additionally, the degradate CGA
- 249287 was modeled separatel y. **Table A** **- 4**  **. CGA** **- 249287**  **PRZM -**  **GW Input**  **Pa rameters**  **for mod**  **eling applications**  **of cyprodinil on**  **grapes PARAMETER (units)**  **VALUE 1**  **SOURCE COMMENT** 

**Application date (day/m** **onth)** 30
- 05 Label. App lication s are set to occur close to date of maturation. Delmarva emergence 10
- 04, crop maturation 30
-

05, harvest 15
- 06 01
- 06 FL citrus crop emergence 01
- 01, crop maturation 01
- 02, harvest 31
- 12 21
- 04 FL potatoes emergence 15
- 02, crop maturation 01
- 05, harvest 01
- 06 01
- 08 GA coast emergence 01
- 05, crop maturation 01
- 08, harvest 01
- 10 01
- 08 NC coast emergence 15
- 05, crop maturation 01
- 08, harvest 01
- 11 21
- 07 WI sand emergence 01
- 05, crop maturation 21
- 07, harvest 20
- 10 **Maximum Application Rate (kg a.i./ha)**  0.0367 Label Maximum application rate is 0.0327 lb a.i./A x 3 applications at 7 day intervals. See **Table A -**  **1**
. **Number of Applications per Year**  3 **Retreatm ent Intervals**  **(days)** 7 **Chemical Application Me** **thod (CAM)** 1 Label Soil applied , it is a degradate
. **Incorporation Depth (cm** **)** 0
--- **Air diffusion coefficient (cm** **2 /day)**  0 .0 N/A Assuming no volatilization. **Vaporization enthalpy (kcal/mol)**  0 .0 N/A Assuming no volatilization. **Henry’s Law Constant (**  **atm -**  **m 3** **/m ol)**  0 .0 N/A Assuming no volatilization. **Partition Coefficient (K** **d ; mL/g)**  3.97 43709047, 43908431 Sorption is not correlated with OC. Mean Kd

value among the following values 0.31, 3.48, 3.88, 5.23, and 6.97 ml/g. **Aerobic Soil Metabolism Half**  **- life (days)**  216 4 3908425, 43908426, 43709045, 43709046 3X available value
. **Hydrolysis Half**

**- life (days)**  0 437090
- 44 Assumed to be stable. 1 Parameters are selected as per “Guidance for Selecting Input Parameters for Modeling Pesticide Concentrations in Groundwater Using the Pesticide Root Zone Model” v.1.0, dated October 15, 2012. 

### Results are provided in **Table A -**  **5**
. **Table A** **- 5** 
. **CGA -** **249287 Estimated**  **Drinking Water**  **Concentrations (EDWCs)**  **resulting from the use of Cyprodinil on**  **grapes Crop/Scenario**  **Highest Daily Value**  **(μg/L) Post Breakthrough**  **Average (μg/L)**  **Average Sim ulation** 

**Breakthrough Time (days)**  Grape s/Tier I Delmarva 1 0.406 0.365 33042 Grapes/Tier I FL citrus 1 2.02 1.77 17629

### 11 **Crop/Scenario Highest Daily**  **Value (μg/L)**  **Post Breakthrough Average**  **(μg/L) Average Sim** **ulation**

**Breakthrough Time (days)**  Grapes/Tier I FL potatoes 1 0.345 0.301 15073 Grapes/Tier I GA coast 1 0.516 0.43 25955 Grapes/Tier I NC coast 1 0.0511 Incomplete 2 Incomplete 2 Grapes/Tier I WI sand 1 0.00949 Incomplete 2 Incomplete 2 1 This scenario was run with an extended weather file
. 2 Incomplete despite running an extended weather file.