Initial to indicate certification as to information on this page

(full text of certification is on page one).

Date

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. 

Use additional sheet(s) if necessary.

2. Case # and Name 3. Date and Type of DCI and Number

4. EPA Product 

Registration

5. I wish to cancel 

this product 

registration 

voluntarily

6. Generic Data 7. Product Specific Data

6a. I am claiming a Generic Data 

Exemption because I obtain the 

active ingredient from the source 

EPA registration number listed 

below.

6b. I agree to satisfy Generic Data

Requirements as indicated on the 

attached form entitled 

"Requirements Status and 

Registrant's Response."

7a. My product is an MUP and I 

agree to satisfy the MUP 

requirement on the attached form

entitled "Requirements Status and

Registrant's Response."

7b. My product is an EUP and I 

agree to satisfy the EUP 

requirement on the attached form 

entitled "Requirements Status and 

Registrant's Response."

OMB Approval 2070-0174

EPA FORM 6300-4

1. Company Name and Address

ADAMA AGAN LTD.

3120 HIGHWOODS BLVD., SUITE 100

RALEIGH, NC 27604 

2490 - Oxyfluorfen

Chemical # and Name: 111601

Oxyfluorfen

12-Jan-2016

GENERIC

ID # GDCI-111601-1515

United States Environmental Protection Agency

Washington, D.C. 20460

DATA CALL-IN RESPONSE

Page 1 of 1

11603-29

8. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any

knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.

Signature and Title of Company's Authorized Representative ______________________________________________________

10. Name of Company

N/A N/A

9. Date

11. Phone Number 
Initial to indicate certification as to information on this page (full text of certification is on page one) 

13. Phone Number

10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any 

knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.

12. Name of Company

11. Date

OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________

ADAMA AGAN LTD.

3120 HIGHWOODS BLVD., SUITE 100

RALEIGH, NC 27604 

Environmental Fate Data Requirements (Conventional 

Chemical)

Post-Application Exposure Data Requirements (Conventional 

Chemical)

Terrestrial and Aquatic Nontarget Organisms Data 

Requirements (Conventional Chemical)

835.2240

835.4300

835.4400

875.2100

850.1075

850.1400

Direct photolysis rate of parent and degradates in 

water

Aerobic aquatic metabolism

Anaerobic aquatic metabolism

Foliar dislodgeable residue dissipation

Fish acute toxicity test, freshwater and marine

Fish early-life stage toxicity test

2490 - Oxyfluorfen

Chemical # and Name: 111601

Oxyfluorfen

12-Jan-2016

GENERIC

ID # GDCI-111601-1515

J,U,I,M,II,Q,C,R,A

J,U,I,M,II,Q,C,R,A

J,U,I,M,II,Q,C,R,A

J,U,I,M,II,Q,C,R,A

J,U,I,M,II,Q,C,R,A

J,U,I,M,II,Q,C,R,A

TGAI

TGAI

TGAI

TEP

TGAI

TGAI

12

24

24

12

12

12

Page 1 of 

(13)

(13)

(1)

(7)

(6, 14)

N

N

N

Y

N

N

3
OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

ADAMA AGAN LTD.

3120 HIGHWOODS BLVD., SUITE 100

RALEIGH, NC 27604 

Terrestrial and Aquatic Nontarget Organisms Data 

Requirements (Conventional Chemical)

Toxicology Data Requirements (Conventional Chemical)

850.2100

850.3040

870.3200

850.6100

SS-1113

SS-1311

Avian acute oral toxicity test

Field testing for pollinators

21/28-day dermal toxicity

Environmental Chemistry Methods and Associated 

Independent Laboratory Validation

Residue Analysis of Nectar and Pollen in Flowering 

Crops

Honey bee adult acute oral toxicity

2490 - Oxyfluorfen

Chemical # and Name: 111601

Oxyfluorfen

12-Jan-2016

GENERIC

ID # GDCI-111601-1515

J,U,I,M,II,Q,C,R,A

J,U,I,M,II,Q,C,R,A

J,U,I,M,II,Q,C,R,A

J,U,I,M,II,Q,C,R,A

J,U,I,M,II,Q,C,R,A

J,U,I,M,II,Q,C,R,A

TGAI

TEP

TGAI

TGAI

TEP

TGAI

12

24

24

24

24

12

Page 2 of 

(5)

(4, 13)

(13)

(2, 13)

(12, 13)

(8)

N

Y

N

N

Y

Y

3
Date

OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

ADAMA AGAN LTD.

3120 HIGHWOODS BLVD., SUITE 100

RALEIGH, NC 27604 

SS-1312

SS-1313

SS-1314

SS-1319

Honey bee larvae acute oral toxicity

Honey bee adult chronic oral toxicity

Honey bee larvae chronic oral toxicity

Semi-field testing for pollinators (tunnel or colony 

feeding studies)

2490 - Oxyfluorfen

Chemical # and Name: 111601

Oxyfluorfen

12-Jan-2016

GENERIC

ID # GDCI-111601-1515

J,U,I,M,II,Q,C,R,A

J,U,I,M,II,Q,C,R,A

J,U,I,M,II,Q,C,R,A

J,U,I,M,II,Q,C,R,A

TGAI

TGAI

TGAI

TEP

12

12

12

24

Page 3 of 

(11)

(9)

(10)

(3, 13)

Y

Y

Y

Y

3
United States Environmental Protection Agency 

Washington, D.C. 20460

FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS

2490 - Oxyfluorfen

GDCI-111601-1515

1

2

3

4

Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active 

Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

This study is to be completed using a bulb vegetable crop; see the Scoping Document for details. Protocols must be submitted for approval prior to the initiation of the study. Details for 

developing protocols are available from the Agency at http://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/test-guidelines-pesticide-data-requirements.

This study and its requirements (ECM/ILV) is needed for both soil and water.

The need for a semi-field test for pollinators (i.e., either a field-feeding test or a tunnel test) will be determined based upon lower-tiered tests and/or other lines of evidence, and the need for a 

refined pollinator risk assessment.

Formal guidelines for semi-field tests do not yet exist; however, information that can help guide the development of either a semi-field tunnel test protocol can be found at OECD 75, see: OECD. 

2007. Series on Testing and Assessment Number 75. Guidance document on the honey bee (Apis mellifera L.) brood test under semi-field conditions. Environmental Directorate Joint Meeting of 

the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology. ENV/JM/MONO(2007)22. 31-Aug-2007. 

http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=env/jm/mono(2007)22&doclanguage=en. 

For field-feeding studies see: Oomen et al. 1992: Oomen, P. A. A. DeRuijter and J. Van der Steen. 1992. Method for honey bee brood feeding tests with insect growth-regulating insecticides. 

Bul OEPP/EPPO Bulletin 22: 613 ¿ 616.

See also the guidance identified in the EPA document, Guidance Implementation of Exposure and Effects Testing for Assessing Risks to Bees, Appendix 2. 

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation.

The need for a field test for pollinators will be determined based upon lower-tiered tests and/or other lines of data and the need for a refined pollinator risk assessment.

Case # and Name:

DCI Number:

Page: 1 of

Footnotes: The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. 

These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement.

Use Categories Key:

A - Terrestrial food crop

C - Terrestrial nonfood crop

I - Greenhouse nonfood crop

J - Forestry use

M - Indoor nonfood use

Q - Residential outdoor use

R - Agricultural premises and equipment

U - Residential and public access premises

II - Residential Use Conventional Chemical

3
United States Environmental Protection Agency 

Washington, D.C. 20460

FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS

2490 - Oxyfluorfen

GDCI-111601-1515

5

6

7

8

9

10

Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active 

Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

See information and guidance identified in the EPA documents, (i) USEPA. 2012. White Paper in Support of the Proposed Risk Assessment Process for Bees. Submitted to the FIFRA Scientific 

Advisory Panel for Review and Comment September 11 ¿ 14, 2012. Office of Chemical Safety and Pollution Prevention Office of Pesticide Programs Environmental Fate and Effects Division, 

Environmental Protection Agency, Washington DC; Environmental Assessment Directorate, Pest Management Regulatory Agency, Health Canada, Ottawa, CN; California Department of Pesticide 

Regulation http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2012-0543-0004; (ii) 2014 Guidance for Assessing Pesticide Risks to Bees. Office of Pesticide Programs United States

Environmental Protection Agency, Health Canada Pest Management Regulatory Agency, California Department of Pesticide Regulation. June 19, 2014. 

http://www2.epa.gov/sites/production/files/2014-06/documents/pollinator_risk_assessment_guidance_06_19_14.pdf ; and, (iii) EPAs Guidance Implementation of Exposure and Effects Testing 

for Assessing Risks to Bees, Appendix 3. 

USEPA. 2012c. ¿Field Testing for Pollinators.¿ Ecological Effects Test Guidelines OCSPP 850.3040. EPA 712-C-017. Web. http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPPT-2009-

0154-0018

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation.

Test is for a passerine species only.

Study is being request only for estuarine/marine fish.

Specific requirements for this study can be found in table 11-3 of the problem formulation (PF) for oxyfluorfen. The Agency is requesting an estuarine/marine fish study, or a freshwater study 

specifically with the fathead minnow, not both studies as indicated in the study title.

See the OECD 213: OECD Guidelines for the Testing of Chemicals. Honeybees, Acute Oral Toxicity Test. 213. http://lysander.sourceoecd.org/vl=5988235/cl=12/nw=1/rpsv/cgibin/fulltextew.pl?prpsv=/ij/oecdjournals/1607310x/v1n2/s14/p1.idx

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation.

OECD has not yet finalized test guidelines for chronic studies, and efforts are underway to develop standardized guidelines for assessing the effects from chronic exposure to adult and larvae 

in the laboratory. 

Discussion of the study design elements for the 10-day adult toxicity test can be found in Appendix O of the European Food Safety Authority (EFSA) guidance document: EFSA. Guidance on the

risk assessment of plant protection products on bees (Apis mellifera, Bombus spp. and solitary bees. EFSA Journal 2013;11(7):3295, 266 pp. doi:10.2903/j.efsa.2013.3295. 

Available online at: http://www.efsa.europa.eu/en/efsajournal/doc/3295.pdf.

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation.

OECD has not yet finalized test guidelines for chronic studies with honey bee larvae. OECD draft guidance has is being developed, see OECD 2013b. OECD Draft Guidance Document Honey 

Bee (Apis mellifera) Larval Toxicity Test, Repeated Exposure. 

 http://www.oecd.org/env/ehs/testing/Draft_GD_honeybees_rep_exp_for_2nd_CR_25_November_2013.pdf

In some cases, information pertaining to acute toxicity to honey bee larvae may be obtained with the chronic honey bee larvae test thereby negating the need for separate acute and chronic 

larval toxicity tests.

See also the guidance identified in the EPA document, Guidance Implementation of Exposure and Effects Testing for Assessing Risks to Bees, Appendix 1.

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation.

Case # and Name:

DCI Number:

Page: 2 of 3
United States Environmental Protection Agency 

Washington, D.C. 20460

FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS

2490 - Oxyfluorfen

GDCI-111601-1515

11

12

13

14

Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active 

Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

OECD Test Guideline 237 may be used to develop a protocol for this study (OECD. 2013 Guidelines for Testing Chemicals. Honey bee (Apis mellifera) larval toxicity test, single exposure.) See: 

http://www.oecd-ilibrary.org/environment/test-no-237-honey-bee-apis-mellifera-larval-toxicity-test-single-exposure_9789264203723-en 

In some cases, information pertaining to acute toxicity to honey bee larvae may be obtained with the chronic honey bee larvae test thereby negating the need for separate acute and chronic 

larval toxicity tests. 

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation.

Measurements of residues in the pollen/nectar are needed based upon lower-tiered tests and/or other lines of evidence, and the need for a refined pollinator risk assessment.

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation. The following elements should be considered when developing study protocol(s) for the monitoring of 

residues in pollen/nectar.

Consideration of the range of application methods and environmental conditions (e.g., soil and hydric regimes) that the target crop(s) may be under.

Consideration of the attractiveness of the selected crop to pollinators

Consideration of a collection schedule sufficient to allow for an understanding of the character of residues, in the pollen/nectar and/or plant tissues, over time.

Consideration of data sufficient to determine whether residues of the active ingredient and/or degradation product(s) accumulates in soil and is/are bioavailable for plant to uptake in a following 

planting, and therefore result in potential exposure to pollinators.

Consideration of the market proportion of the selected target crop(s).

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation.

For each study having a 24-month time frame, a progress report at 9 months and 18 months is required to be submitted to the Agency.

Data are preferred on sheepshead minnow (Cypinodon variegatus).

Case # and Name:

DCI Number:

Page: 3 of 3
United States Environmental Protection Agency 

Washington, D.C. 20460

LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE

Case # and Name: 2490 - Oxyfluorfen

Page: 1 of 1

87283

62719

70506

11603

42750

WILLOWOOD OXYFLUORFEN, LLC

DOW AGROSCIENCES LLC

UNITED PHOSPHORUS, INC

ADAMA AGAN LTD.

ALBAUGH, LLC

Co. Nr. Company Name Agent For Company

PYXIS REGULATORY 

CONSULTING, INC.

MAKHTESHIM-AGAN OF NORTH 

AMERICA INC

4110 136TH STREET, NW

9330 ZIONSVILLE RD 308/2E

630 FREEDOM BUSINESS CENTER, SUITE 402

3120 HIGHWOODS BLVD., SUITE 100

P.O. Box 2127

Address City ZIP

GIG HARBOR

INDIANAPOLIS

KING OF PRUSSIA

RALEIGH

VALDOSTA

98332 

462681054

19406 

27604 

316042127

OMB Approval 2070-0174

State

WA

IN

PA

NC

GA

 DCI Number: GDCI-111601-1515
United States Environmental Protection Agency 

Washington, D.C. 20460

LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE

Case # and Name: 2490 - Oxyfluorfen

Page: 1 of 1

87283

62719

70506

11603

42750

WILLOWOOD OXYFLUORFEN, LLC

DOW AGROSCIENCES LLC

UNITED PHOSPHORUS, INC

ADAMA AGAN LTD.

ALBAUGH, LLC

Co. Nr. Company Name Agent For Company

PYXIS REGULATORY 

CONSULTING, INC.

MAKHTESHIM-AGAN OF NORTH 

AMERICA INC

4110 136TH STREET, NW

9330 ZIONSVILLE RD 308/2E

630 FREEDOM BUSINESS CENTER, SUITE 402

3120 HIGHWOODS BLVD., SUITE 100

P.O. Box 2127

Address City ZIP

GIG HARBOR

INDIANAPOLIS

KING OF PRUSSIA

RALEIGH

VALDOSTA

98332 

462681054

19406 

27604 

316042127

OMB Approval 2070-0174

State

WA

IN

PA

NC

GA

 DCI Number: GDCI-111601-1515
United States Environmental Protection Agency 

Washington, D.C. 20460

LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE

Case # and Name: 2490 - Oxyfluorfen

Page: 1 of 1

87283

62719

70506

11603

42750

WILLOWOOD OXYFLUORFEN, LLC

DOW AGROSCIENCES LLC

UNITED PHOSPHORUS, INC

ADAMA AGAN LTD.

ALBAUGH, LLC

Co. Nr. Company Name Agent For Company

PYXIS REGULATORY 

CONSULTING, INC.

MAKHTESHIM-AGAN OF NORTH 

AMERICA INC

4110 136TH STREET, NW

9330 ZIONSVILLE RD 308/2E

630 FREEDOM BUSINESS CENTER, SUITE 402

3120 HIGHWOODS BLVD., SUITE 100

P.O. Box 2127

Address City ZIP

GIG HARBOR

INDIANAPOLIS

KING OF PRUSSIA

RALEIGH

VALDOSTA

98332 

462681054

19406 

27604 

316042127

OMB Approval 2070-0174

State

WA

IN

PA

NC

GA

 DCI Number: GDCI-111601-1515
United States Environmental Protection Agency 

Washington, D.C. 20460

LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE

Case # and Name: 2490 - Oxyfluorfen

Page: 1 of 1

87283

62719

70506

11603

42750

WILLOWOOD OXYFLUORFEN, LLC

DOW AGROSCIENCES LLC

UNITED PHOSPHORUS, INC

ADAMA AGAN LTD.

ALBAUGH, LLC

Co. Nr. Company Name Agent For Company

PYXIS REGULATORY 

CONSULTING, INC.

MAKHTESHIM-AGAN OF NORTH 

AMERICA INC

4110 136TH STREET, NW

9330 ZIONSVILLE RD 308/2E

630 FREEDOM BUSINESS CENTER, SUITE 402

3120 HIGHWOODS BLVD., SUITE 100

P.O. Box 2127

Address City ZIP

GIG HARBOR

INDIANAPOLIS

KING OF PRUSSIA

RALEIGH

VALDOSTA

98332 

462681054

19406 

27604 

316042127

OMB Approval 2070-0174

State

WA

IN

PA

NC

GA

 DCI Number: GDCI-111601-1515
United States Environmental Protection Agency 

Washington, D.C. 20460

LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE

Case # and Name: 2490 - Oxyfluorfen

Page: 1 of 1

87283

62719

70506

11603

42750

WILLOWOOD OXYFLUORFEN, LLC

DOW AGROSCIENCES LLC

UNITED PHOSPHORUS, INC

ADAMA AGAN LTD.

ALBAUGH, LLC

Co. Nr. Company Name Agent For Company

PYXIS REGULATORY 

CONSULTING, INC.

MAKHTESHIM-AGAN OF NORTH 

AMERICA INC

4110 136TH STREET, NW

9330 ZIONSVILLE RD 308/2E

630 FREEDOM BUSINESS CENTER, SUITE 402

3120 HIGHWOODS BLVD., SUITE 100

P.O. Box 2127

Address City ZIP

GIG HARBOR

INDIANAPOLIS

KING OF PRUSSIA

RALEIGH

VALDOSTA

98332 

462681054

19406 

27604 

316042127

OMB Approval 2070-0174

State

WA

IN

PA

NC

GA

 DCI Number: GDCI-111601-1515