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# OAR Box 

# 1850 Prepped byOllie Stewart



### Document

Number: 

# 76 ) IV-B- 6
Docket Number: 

# A-90-0 7

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### 2 5 1994

MEMORANDU

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SUBJECT :

FROM :

THRU :

TO : Referenc e Lis t o f Selecte dMoto r Vehicl e

Exhaus t Inhalatio nToxicolog yStudie s



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1 Ken t Helmer , Toxicologis t Specia l Regulator yProject s Branch ' Judit hGray , Senio r Projec t Manager 'JlJuJUy^^^^X^^^ ' Specia l Regulator yProject s Branc h/ / ) Ai r Docke t no . A-90-0 7

Attache di s a lis t o f selecte dreference s t o inhalatio n toxicolog ystudies , i nwhic htes t animal s hav e bee nexpose dt o moto r vehicl e exhaust
. Include dar e si xstudie s o f gasolin e emissio nexposur e andnin e studie s o f diese l emissio nexposure . Attachmen tP. 3

Selecte dReference s toMoto r Vehicl e Emissio n

Inhalatio nToxicology Studie s

1 ) DIESE L EXHAUST :

a ) Brightwell , J. , Fouillet , X. , Cassano-Zoppi , A-L. , Gatz , R. , Duchosal , F
. "Neoplasti c an dFunctiona l Change s i n Rodent s Afte r Chroni c Inhalatio no f Engin e Exhaus t Emissions" , in : Carcinogeni c an dMutageni c Effect s o f Diese l Engin e Exhaust
. Development s i nToxicolog yan dEnvironmenta l Scienc e Series , Vol
. 1 3 (Ishinishi , N. , Koizumi , A. , McClellan , R.O. , Stober , W. , eds. ) Elsevie r Scienc e Publishin g Co. , Ne wYork , NY
. pp . 471-485 , 1986
.b ) Heinrich , U. , Muhle , H. , Takenaka , S. , Ernst , H. , Fuhst , R. , Mohr , U. , Pott , F. , Stober , W
. "Chroni c Effect s o nth e Respirator yTrac t o f Hamsters , Mic e an dRat s Afte r Long-ter m Inhalatio no f Hig hConcentration s o f Filtere dan dUnfiltere d Diese l Engin e Emissions " J
. Appl
. Toxicol

. 6 : 383-395 , 1986
.
c ) Heinrich , U. , Pott , F. , Rittinghausen , S
. "Compariso no f Chroni c Inhalatio nEffect s i nRodent s Afte r Long-ter mExposur e t o Eithe r Coa l Ove nFlu e Ga s mixe dwit hPyrolize dPitc ho r Diese l Engin e Exhaust" , in : Carcinogeni c an dMutageni c Effect s o f Diese l Engin e Exhaust
. Development s i nToxicolog yan dEnvironmenta l Scienc e Series , Vol
. 1 3 (Ishinishi , N. , Koizumi , A. , McClella n R.O. , Stober , W. , eds. ) Elsevie r Scienc e Publishin g Co. , Ne w York , NY
. pp . 441-457 , 1986
. r

r d ) Ishinishi , N. , Kuwabara , N. , Nagase , S. , Suzuki , T , Ishiwata , S. , Kohno , T
. "Long-ter mInhalatio nStudie s o nth e Effect s o f Exhaus t fro mHeavyan dLigh t Dut yDiese l Engine s o n F34 4 rats " in : Carcinogeni c an dMutageni c Effect s o f Diese l Engin e Exhaust
. Development s i nToxicolog yan dEnvironmenta l Scienc e Series , Vol
. 1 3 (Ishinishi , N. , Koizumi , A. , McClellan , R.O. , Stober , W. , eds. ) Elsevie r Scienc e Publishin g Co. , Ne w York , NY
. pp . 329-348 , 1986
.
e ) Karagianes , R. , Palmer , R. , Busch , R
. "Effect s o f Inhale dDiese l Emission s an dCoa l Dus t i nRats " Am
. Ind
. Hyg
. Assoc
. J
. 42 : 382-391 , 1981
. f ) Lewis , T. , Green , F. , Moorman , W. , Burg , J. , Lynch , D
. " AChroni c Inhalatio nToxicit yStudyo f Diese l Engin e Emission s an dCoa l Dus t Alon e an dCombined" , in : Carcinogeni c an dMutageni c Effect s o f Diese l Engin e Exhaust
. Development s i nToxicolog yan d Environmenta l Scienc e Series , Vol
. 1 3 (Ishinishi , N. , Koizumi , A. , McClella n, R.O. , Stober , W. , eds. ) Elsevie r Scienc e Publishin g Co. , Ne wYork , NY
. pp . 361-380 , 1986
.P. 4

g ) Mauderly , J. , Jones , R. , McClellan , R. , Henderson , R. , Griffith , W
. "Carcinogenicit yo f Diese l Exhaus t Inhale d Chronicall ybyRats" , in : Carcinogeni c an dMutageni c Effect s o f Diese l Engin e Exhaust
. Development s i nToxicolog yan d Environmenta l Scienc e Series , Vol
. 1 3 (Ishinishi , N. , Koizumi , A. , McClellan , R.O. , Stober , W. , eds. ) Elsevie r Scienc e Publishin g Co. , Ne wYork , NY
. pp . 397-409 , 1986
. h ) Stober , W
. "Experimenta l Inductio no f Tumor s i n Hamsters , Mice , an dRat s Afte r Long-ter mInhalatio no f Filtere d an dUnfiltere dDiese l Engin e Exhaust " in : Carcinogeni c an d Mutageni c Effect s o f Diese l Engin e Exhaust
. Development s i n Toxicolog yan dEnvironmenta l Scienc e Series , Vol
. 1 3 (Ishinishi , N. , Koizumi , A. , McClellan , R.O. , Stober , W. , eds. ) Elsevie r Scienc e Publishin g Co. , Ne wYork , NY
. pp . 421-439 , 1986
. i ) Wolff , R. , Henderson , R. , Snipes , M. , Griffith , W. , Mauderly , J. , Cuddihy , R. , McClellan , R
. "Alteration s i nParticl e Accumulatio nan dClearanc e i nLung s o f Rat s Chronicall yExpose d t o Diese l Exhaust " Fun
. Appl
. Toxicol

. 9:154-166 , 1987
.
2 ) GASOLIN E EXHAUST : a ) * Brightwell , J. , Fouillet , X. , Cassano-Zoppi , A-L. , Gatz , R. , Duchosal , F
. "Neoplasti c an dFunctiona l Change s i nRodent s Afte r Chroni c Inhalatio no f Engin e Exhaus t Emissions" , in : Carcinogeni c an dMutageni c Effect s o f Diese l Engin e Exhaust
. Development s i n Toxicolog yan dEnvironmenta l Scienc e Series , Vol
. 1 3 (Ishinishi , N. , Koizumi , A. , McClellan , R.O. , Stober , W. , eds. ) Elsevie r Scienc e Publishin g Co. , Ne wYork , NY
. pp . 471-485 , 1986
. b ) * Heinrich , U. , Pott , F. , Rittinghausen , S
. "Compariso no f Chroni c Inhalatio nEffect s i nRodent s Afte r Long-ter mExposur e t o Eithe r Coa l Ove nFlu e Ga s mixe dwit hPyrolize dPitc ho r Diese l Engin e Exhaust" , in : Carcinogeni c an dMutageni c Effect s o f Diese l Engin e Exhaust
. Development s i nToxicolog yan dEnvironmenta l Scienc e Series , Vol
. 1 3 (Ishinishi , N. , Koizumi , A. , McClella n, R.O. , Stober , W. , eds. ) Elsevie r Scienc e Publishin g Co. , Ne w York , NY
. pp . 441-457 , 1986
.
c ) Lewis , T. , Moorman , W. , "Pulmonar yan dCardiovascula r Physiolog yStudie s Durin g Exposure" , in : Long-ter mEffect s o f Ai r Pollutant s i nCanin e Species : Serie s no . 8
. (Stara , J. , Dungworth , L. , Orthoefer , J. , Tyler , W. , eds. ) Californi a Universit y(Davis) , Environmenta l Protectio nAgency , EPA-600/8

- 80-01 4 (NTIS # PB81-144875 ) July , 1980
. d ) Massad , E. , Hilario , P. , Saldiva , N. , Saldiva , C , Caldeira , M. , Cardoso , L. , Morais , M. , Calheiros , D. , d e Silva , R. , Bohm , G. , "Toxicit yo f Prolonge dExposur e t o Ethano l an dGasolin e Autoengin e Exhaus t Gases " Eviron

. Res
. 40:479-486 , 1986
.P. 5



### e ) Pepelko , W. , e t

al. , "Effec t

o f 90Day s Exposur et o Catalytically-treate dAutomobil eExhaus t i nRats " Environ

. Res

. 19:91-101 , 1979

. f ) Stara , J. , Busch , K. , Hinners , R. , Burkart , J. , "Stud y Overview , Rationale , Experienta lesign , Experimenta lFacilities , an dExposur eAtmospheres" , in : Long-ter mEffect s o f Ai r Pollutant s i nCanin eSpecies : Serie s no . 8

. (Stara , J. , Dungworth , L. , Orthoefer , J. , Tyler , W. , eds. ) Californi a Universit y(Davis) , Environmenta lProtectio nAgency , EPA-600/8

- 80-01 4(NTIS#PB81-144875 ) July , 1980

.

* Thes epaper s includ ediscussio no f gasolin eemissio ninhalatio nstudies , a s wel la s diesel

.