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                            Funding & Awards
 Population Genetic Issues for Forensic DNA Profiles
Award Information
Awardee
              UNIVERSITY OF WASHINGTON
Award #
              2020-DQ-BX-0022
Funding Category
              Competitive Discretionary
Location
                    SEATTLE, WA
Congressional District
              7
Status
              Past Project Period End Date
Funding First Awarded
              2020
Total funding (to date)
              $711,906
Original Solicitation
              Research and Development in Forensic Science for Criminal Justice Purposes, Fiscal Year 2020
Description of original award (Fiscal Year 2020, $711,906)
This application is for continued support of a highly productive team of statistical geneticists, forensic scientists, and statisticians at the University of Washington, the Institute of Environmental Science and Research in New Zealand, and the University of Auckland, New Zealand. These investigators will continue working to produce statistical procedures for providing quantitative strength to DNA evidence. Their work will extend population genetic theory for accommodating population structure in calculating match probabilities for autosomal and lineage markers, and combinations of these markers. A survey will be made of published Y-chromosome haplotype frequencies in order to compare the performance of alternative approached for calculating match probabilities. The investigators will also address the population genetic issues arising from the forensic use of next-generation sequencing. Attention will be paid to determining the appropriate value of theta to determine match probabilities for sequence-derived profiles, and for combining inferred STR profiles and sequence-based profiles. The widespread biomedical use of single nucleotide polymorphisms has enabled genealogical-database searches for forensic purposes, and the underlying statistical methodology will be examined to determine possible extensions of their use.
The primary outcome of the proposed work will be peer-reviewed publications, although the work will inform the investigators' many teaching activities and service on forensic advisory panels and editorial boards. Note: This project contains a research and/or development component, as defined in applicable law, and complies with Part 200 Uniform Requirements - 2 CFR 200.210(a)(14). CA/NCF



  
Grant-Funded Publications
        
                      A Diagnosis of the Primary Difference between EuroForMix and STRmixTM
                  Commentary On: Thompson WC. Uncertainty in Probabilistic Genotyping of Low Template DNA: A Case Study Comparing STRmixTM and TrueAlleleTM
                  Estimation of population specific values of theta for sequence-based STR profiles
                  An Investigation into Compound Likelihood Ratios for Forensic DNA Mixtures
                  Addressing uncertain assumptions in DNA evidence evaluation
                  Combining artificial neural network classification with fully continuous probabilistic genotyping to remove the need for an analytical threshold and electropherogram reading
                  Evaluating DNA Mixtures with Contributors from Different Populations Using Probabilistic Genotyping
                  Extending the discrete Laplace method: Incorporating multi-copy loci, partial repeats and null alleles
                  The number of alleles in DNA mixtures with related contributors
                  A tool for simulating single source and mixed DNA profiles
                  Guiding proposition setting in forensic DNA interpretation
                  Investigation into the effect of mixtures comprising related people on non-donor likelihood ratios, and potential practises to mitigate providing misleading opinions
                  Re: Riman et al. Examining performance and likelihood ratios for two likelihood ratio systems using the PROVEDIt dataset
                  A new implementation of a semi-continuous method for DNA mixture interpretation
                  A Logical Framework for Forensic DNA Interpretation
                  The transitivity of the Hardy-Weinberg law
                  Streamlining the decision-making process for international DNA kinship matching using Worldwide allele frequencies and tailored cutoff log(10)LR thresholds
                  Elephant genotypes reveal the size and connectivity of transnational ivory traffickers
                  Exploring likelihood ratios assigned for siblings of the true mixture contributor as an alternate contributor
                  An experimental extension to the discrete Laplace method for Y-STR haplotype frequency estimation
                  The effect of a user selected number of contributors within the LR assignment
                  A mixed DNA profile controversy revisited
                  A comparison of likelihood ratios obtained from EuroForMix and STRmixTM
                  Evaluating DNA evidence possibly involving multiple (mixed) samples, common donors and related contributors
                  Relaxing the assumption of unrelatedness in the numerator and denominator of likelihood ratios for DNA mixtures
                  Can a reference 'match' an evidence profile if these have no loci in common?
                  Comparing multiple POI to DNA mixtures
                  Estimating the number of contributors to a DNA profile using decision trees
                  Exploring the advantages of amplifying the entire extract versus splitting the extract and interpreting replicates using a continuous model of interpretation
                  Modeling allelic analyte signals for aSTRs in NGS DNA profiles
                  Probabilistic interpretation of the Amelogenin locus
                  Validation of a top-down DNA profile analysis for database searching using a fully continuous probabilistic genotyping model
                  When Evaluating DNA Evidence within a Likelihood Ratio Framework, should the Propositions be Exhaustive?

  
Date Created: October 22, 2020
    
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