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                            Funding & Awards
 Enhancing and Sustaining the ALFRED-FROG-KB Forensic Resource
Award Information
Awardee
              Yale University
Award #
              2016-DN-BX-0162
Funding Category
              Competitive
Location
                    New Haven, CT
Congressional District
              3
Status
              Open
Funding First Awarded
              2016
Total funding (to date)
              $1,062,736
Original Solicitation
              Research and Development in Forensic Science for Criminal Justice Purposes
Description of original award (Fiscal Year 2016, $1,062,736)
As submitted by the proposer: 

With the introduction of massively parallel sequencing (MPS) technology into forensics, it seems clear that forensic practice will be using single nucleotide polymorphisms (SNPs) in the near future. Kits are already being introduced to provide relevant information that the current forensic markers, short tandem repeat polymorphisms (STRPs), cannot provide--such as information on ancestry and visible traits such as hair, eye, and skin color. These applications require a large reference database on allele frequencies of SNPs in multiple populations around the world. The existing large database developed at Yale by Prof. K. Kidd and his group and the web interfaces ALFRED (Allele Frequency Database) and FROG-kb (Forensic Resource/Reference on Genetics knowledge base) that allow access to and forensic use of the data will be enhanced with more data and better functionality for use in forensic practice. A new type of marker, microhaplotypes, has been developed especially for MPS and will be powerful for mixture deconvolution. The work over a two-year period will involve ongoing curation and entry of public data into the database. In addition, the web interfaces will have additional search and display functions as well as additional didactic information on aspects of the human population genetics and forensic principles. A major effort will be made to incorporate microhaplotypes into the calculations available in FROG-kb. Additional statistical capability will be incorporated into the FROG-kb interface. These improvements will facilitate the transition to use of SNPs in forensic practice and provide tools for their implementation. At the same time the database structure will be translated into SQL Server to make it easier to find a new host for the data and functions at the end of the project when Prof. Kidd will be retiring.

Note:  This project contains a research and/or development component, as defined in applicable law.

ca/ncf



  
Grant-Funded Publications
        
                      FrogAncestryCalc: A standalone batch likelihood computation tool for ancestry inference panels catalogued in FROG-kb
                  The distinctive geographic patterns of common pigmentation variants at the OCA2 gene
                  Enhancing and Sustaining the ALFRED-FROG-kb Forensic Resource
                  Usefulness of COMT gene polymorphisms in North African populations
                  Improving Ancestry Distinctions Among Southwest Asian Populations
                  Redesigned Forensic Research/Reference on Genetics-knowledge base, FROG-kb
                  Confounding Effects of Microbiome on the Susceptibility of TNFSF15 to Crohn's Disease in the Ryukyu Islands
                  Genetics of the Peloponnesean Populations and the Theory of Extinction of the Medieval Peloponnesean Greeks

  
Date Created: September 12, 2016
    
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