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                            Funding & Awards
 Population Genetic Issues for Forensic DNA Profiles
Award Information
Awardee
              UNIVERSITY OF WASHINGTON
Award #
              2017-DN-BX-0136
Funding Category
              Competitive Discretionary
Location
                    SEATTLE, WA
Congressional District
              7
Status
              Closed
Funding First Awarded
              2017
Total funding (to date)
              $903,440
Original Solicitation
              NIJ FY17 Research and Development in Forensic Science for Criminal Justice Purposes
Description of original award (Fiscal Year 2017, $903,440)
As submitted by the proposer:
Under this project, the investigators will continue working to produce statistical procedures for providing quantitative strength to DNA evidence. Their work will extend population genetic theory for accommodating population structure in calculating match probabilities for autosomal and lineage markers, and combinations of these markers. The researchers will also employ advanced statistical procedures for using peak heights in electropherograms in order to accommodate allelic drop-out and drop-in in situations with single or multiple contributors, and for Y-chromosome markers.
The new statistical techniques to be developed will emphasize the need for realistic run times for casework mixture interpretation. The investigators will also address the population genetic issues arising from the forensic use of next-generation sequencing. Improvements will be sought for current methods of inferring STR profiles from sequence data, and attention will be paid to determining the appropriate value of theta to determine match probabilities for sequence-derived profile.
The primary outcome of the proposed work will be peer-reviewed publications, although the work will inform the investigators many teaching activities and service on forensic advisory panels and editorial boards.
Note: This project contains a research and/or development component, as defined in applicable law, and complies with Part 200 Uniform Requirements - 2 CFR  200.210(a)(14).
ca/ncf



  
Grant-Funded Publications
        
                      Population Genetic Issues for Forensic DNA Profiles
                  The effect of a user selected number of contributors within the LR assignment
                  Relaxing the assumption of unrelatedness in the numerator and denominator of likelihood ratios for DNA mixtures
                  Estimating the number of contributors to a DNA profile using decision trees
                  What can forensic probabilistic genotyping software developers learn from significant non-forensic software failures?
                  When Evaluating DNA Evidence within a Likelihood Ratio Framework, should the Propositions be Exhaustive?
                  Performance of a method for weighting a range in the number of contributors in probabilistic genotyping
                  Variability and additivity of read counts for aSTRs in NGS DNA profiles
                  A review of DNA profiling success for laser microdissected forensic casework samples
                  A review of likelihood ratios in forensic science based on a critique of Stiffelman "No longer the Gold standard: Probabilistic genotyping is changing the nature of DNA evidence in criminal trials"
                  Are low LRs reliable?
                  Examining the additivity of peak heights in forensic DNA profiles
                  Response to: Commentary on: Bright et al. (2018) Internal validation of STRmix (TM) - A multi laboratory response to PCAST
                  The interpretation of mixed DNA profiles from a mother, father, and child trio
                  Using the Nondonor Distribution to Improve Communication and Inform Decision Making for Low LRs from Minor Contributors in Mixed DNA Profiles
                  Exploring the Probative Value of Mixed DNA Profiles
                  The Efficacy of DNA Mixture to Mixture Matching
                  Inter-Sample Contamination Detection Using Mixture Deconvolution Comparison
                  Interpreting a Major Component From a Mixed DNA Profile With an Unknown Number of Minor Contributors
                  STRmix (TM) collaborative exercise on DNA mixture interpretation
                  Applying calibration to LRs produced by a DNA interpretation software
                  Comment on "DNA Mixtures Interpretation - A Proof-of-Concept Multi-Software Comparison Highlighting Different Probabilistic Methods' Performances on Challenging Samples" by Alladio et al
                  Data on likelihood ratios of two-person DNA mixtures interpreted using semi- and fully continuous systems
                  Exploring the DNA mixture deconvolution through simulation
                  Probabilistic Genotyping Software: An Overview
                  Testing whether stutter and low-level DNA peaks are additive
                  The effect of varying the number of contributors in the prosecution and alternate propositions
                  The interpretation of forensic DNA profiles: an historical perspective
                  NIST Inter-Laboratory Studies Involving DNA Mixtures (MIX13): A Modern Analysis
                  Combating Transnational Organized Crime by Linking Multiple Large Ivory Seizures to the Same Dealer
                  A Sensitivity Analysis To Determine the Robustness of STRmix (TM) With Respect to Laboratory Calibration
                  Implementation and Validation of an Improved Allele Specific Stutter Filtering Method for Electropherogram Interpretation
                  Response to "Likelihood Ratio as Weight of Evidence: A Closer Look" by Lund and Iyer
                  Internal Validation of STRmix (TM) - A Multi Laboratory Response to PCAST
                  Multi-allelic Exact Tests for Hardy-Weinberg Equilibrium that Account for Gender
                  On the testing of Hardy-Weinberg proportions and equality of allele frequencies in males and females at biallelic genetic markers

  
Date Created: September 29, 2017
    
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