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                            Funding & Awards
 Characterization of X Chromosomal Short Tandem Repeat Markers for Forensic Use
Award Information
Awardee
              American Registry of Pathology
Award #
              2011-DN-BX-K401
Funding Category
              Competitive
Location
                    Rockville, MD
Congressional District
              8
Status
              Closed
Funding First Awarded
              2010
Total funding (to date)
              $81,567
Original Solicitation
              NIJ FY 10 Forensic DNA Research and Development
Description of original award (Fiscal Year 2010, $81,567)
The use of X chromosomal short tandem repeat (STR) markers has been greatly increasing in the forensic setting. The marker system offers the potential to provide information in addition to that obtained from autosomal STR systems currently used at crime laboratories and the courtroom, and in certain scenarios, markers on the X chromosome may be the only means of obtaining this information. Any investigated relationship situation where at least one female is involved will benefit from the use of X chromosomal STRs, which can be applied to cases of missing persons, criminal incest, immigration, deficiency paternity or other questioned relationships. In-depth characterization of the marker system is the first step in maximizing the power of this additional tool in the forensic arsenal.  This project will build upon previous work performed at the Armed Forces DNA Identification Laboratory (AFDIL), in which two mini-X chromosomal STR multiplexes capable of amplifying 15 total markers were developed and developmental validation studies have been completed.  The goals of this project are to perform mutation rate studies, linkage analysis, and mixture evaluation in order to further characterize the X chromosomal STR marker system for forensic use.
ca/ncf



  
Grant-Funded Publications
        
                      Genetic Mapping of 15 Human X Chromosomal Forensic Short Tandem Repeat (STR) Loci by Means of Multi-core Parallelization
                  Mutation rates of 15 X chromosomal short tandem repeat markers
                  Population Genetic Data for 15 X Chromosomal Short Tandem Repeat Markers in Three U.S. Populations
                  Characterization of X Chromosomal Short Tandem Repeat Markers for Forensic Use

  
Date Created: September 15, 2011
    
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