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                            Funding & Awards
 Human Hair Proteomics - Improved Evidence Discrimination
Award Information
Awardee
              THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Award #
              2011-DN-BX-K543
Funding Category
              Competitive
Location
                    DAVIS, CA
Awardee County
              YOLO
Congressional District
              3
Status
              Closed
Funding First Awarded
              2011
Total funding (to date)
              $151,150
Original Solicitation
              NIJ FY 11 Basic Scientific Research to Support Forensic Science for Criminal Justice Purposes
Description of original award (Fiscal Year 2011, $151,150)
This research investigates a method to obtain potentially probative information from human hair samples by analyzing their profiles of constituent proteins.  This project exploits recent advances in protein identification by mass spectrometry coupled with database searching.  Previous and ongoing work has shown that mouse strains can be distinguished by their pelage hair proteomes using a small number of sentinel proteins.  The hypothesis will be tested that the proteome of human hair shaft can distinguish among humans by comparing the proteomes of hair samples provided by subjects from Caucasian, Korean and African ancestry.  The hair will be trypsinized and the protein profiles will be determined by a shotgun approach.  From the data, a small subset of sentinel proteins (5-10) will be chosen that are distinctive among the samples analyzed.  In the second phase of the work, the samples will be reanalyzed by a targeted approach.  For this purpose isotopically labeled sentinel proteins or proteotypic peptides from them will be used as internal standards for relative quantitation.  The normalized profiles of proteotypic peptides from sentinel proteins will be compared to find whether individual donor profiles can be reliably distinguished. ca/ncf



  
Grant-Funded Publications
        
                      Elucidation of familial relationships using hair shaft proteomics
                  Comparison of Protein Expression Levels and Proteomically-Inferred Genotypes Using Human Hair From Different Body Sites
                  Proteomic Analysis of Hair Shafts From Monozygotic Twins: Expression Profiles and Genetically Variant Peptides.
                  Demonstration of Protein-Based Human Identification Using the Hair Shaft Proteome
                  Human Hair Proteomics - Improved Evidence Discrimination
                  Human hair shaft proteomic profiling: individual differences, site specificity and cuticle analysis

  
Date Created: September 15, 2011
    
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                  Nanoparticle-Decorated Micropillars As Integrated Raman Spectroscopy and Mass Spectrometry Substrates for Quantitative and High-Throughput Toxicology Drug Analysis
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