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                            Funding & Awards
 Population Genetic Issues for Forensic DNA Profiles
Award Information
Awardee
              University of Washington
Award #
              2011-DN-BX-K541
Funding Category
              Competitive
Location
                    Seattle, WA
Congressional District
              7
Status
              Closed
Funding First Awarded
              2011
Total funding (to date)
              $1,269,456
Original Solicitation
              NIJ FY 11 Basic Scientific Research to Support Forensic Science for Criminal Justice Purposes
Description of original award (Fiscal Year 2011, $1,269,456)
This research considers the following topics: (1) Relatedness and Inbreeding- Related individuals have similar profiles, although the current panels of forensic STR markers do not allow distinguishing among different classes or relatedness. The implications of adding lineage markers, more STR markers, or SNP markers will be explored. Tests of relatedness, as opposed to calculating likelihood ratios for specified degrees of relatedness will be developed. (ii) Population Structure - The interpretation of matching DNA profiles was improved by the 'theta-correction'.  It is proposed to clarify the meaning of 'theta' and to develop appropriate estimates to replace current ad-hoc assumed values. Use will be made of an extensive collection of published allele frequencies from around the world. (iii) Lineage Markers - Mitochondrial sequence and Y-chromosome STR data have the potential of improving relatedness inference, familial searching and the recovery of forensic profiles from degraded samples. It is proposed to work further to remove current uncertainty on how to quantify the evidential strength of these lineage markers when the profiles of interest have not been seen in a database. (iv)Mixtures - As DNA typing technology becomes more sensitive, it is more likely that evidentiary samples contain DNA from multiple contributors. ca/ncf



  
Grant-Funded Publications
        
                      Analyzing Population Structure for Forensic STR Markers in Next Generation Sequencing data
                  A description of the likelihood ratios in the probabilistic genotyping software STRmixTM
                  An examination of aspects of the probabilistic genotyping tool: Forensic Statistical Tool
                  A guide to results and diagnostics within a STRmixTM report
                  Advancing the Statistical Interpretation of Forensic DNA Data Samples
                  Comment on "DNA Mixtures Interpretation - A Proof-of-Concept Multi-Software Comparison Highlighting Different Probabilistic Methods' Performances on Challenging Samples" by Alladio et al
                  The Probabilistic Genotyping Software STRmix: Utility and Evidence for its Validity
                  Modelling the Dependence Structure of Y-STR Haplotypes Using Graphical Models
                  Combating Transnational Organized Crime by Linking Multiple Large Ivory Seizures to the Same Dealer
                  Implementation and Validation of an Improved Allele Specific Stutter Filtering Method for Electropherogram Interpretation
                  Internal Validation of STRmix (TM) - A Multi Laboratory Response to PCAST
                  A Fully Continuous System of DNA Profile Evidence Evaluation That Can Utilize STR Profile Data Produced Under Different Conditions Within a Single Analysis
                  The Paradigm Shift in DNA Profile Interpretation
                  Allele frequency database for GlobalFiler (TM) STR loci in Australian and New Zealand populations
                  Population-Specific F-ST Values for Forensic STR Markers: A Worldwide Survey
                  Validating Multiplexes for Use in Conjunction With Modern Interpretation Strategies
                  Genetic Assignment of Large Seizures of Elephant Ivory Reveals Africa's Major Poaching Hotspots
                  Population Genetic Issues for Forensic DNA Profiles
                  A series of recommended tests when validating probabilistic DNA profile interpretation software
                  More Straightforward Derivation of the LR for a Database Search
                  The Variability in Likelihood Ratios due to Different Mechanisms
                  "Factor of Two" Issue in Mixed DNA Profiles
                  Comparison of the Performance of Different Models for the Interpretation of Low Level Mixed DNA Profiles
                  Considering Relatives When Assessing the Evidential Strength of Mixed DNA Profiles
                  Interpreting Forensic DNA Profiling evidence without specifying the number of contributors
                  Investigation into Stutter Ratio Variability Between Different Laboratories
                  Modeling Forward Stutter: Toward Increased Objectivity in Forensic DNA Interpretation
                  Effect of the Uncertainty in the Number of Contributors to Mixed DNA Profiles on Profile Interpretation
                  Searching Mixed DNA Profiles Directly Against Profile Databases
                  Utilising Allelic Dropout Probabilities Estimated by Logistic Regression in Casework
                  A comparison of statistical models for the analysis of complex forensic DNA profiles
                  An illustration of the effect of various sources of uncertainty on DNA likelihood ratio calculations
                  Characterising the STR Locus D6S1043 and Examination of Its Effect on Stutter Rates
                  Combining autosomal and Y chromosome match probabilities using coalescent theory
                  Helping formulate propositions in forensic DNA analysis
                  Identifying and modelling the drivers of stutter in forensic DNA profiles
                  Investigation into stutter ratio variance
                  Modelling PowerPlex (R) Y stutter and artefacts
                  Uncertainty in the number of contributors for the European Standard Set of loci
                  Variability of mixed DNA profiles separated on a 3130 and 3500 capillary electrophoresis instrument
                  Corrigendum to “Relatedness calculations for linked loci incorporating subpopulation effects”
                  Evaluating Forensic DNA Profiles Using Peak Heights, Allowing for Multiple Donors, Allelic Dropout and Stutters
                  Interpretation of Single Source and Mixed DNA Profiles
                  Investigation Into the Performance of Different Models for Predicting Stutter
                  Relatedness Calculations for Linked Loci Incorporating Subpopulation Effects
                  Application of Random Match Probability Calculations to Mixed STR Profiles
                  Developing Allelic and Stutter Peak Height Models for a Continuous Method of DNA Interpretation
                  Consideration of the probative value of single donor 15-plex STR profiles in UK populations and its presentation in UK courts I
                  Decision-Making in Familial Database Searching: KI Alone or Not Alone?
                  Degradation of forensic DNA profiles
                  Detection of target-probe oligonucleotide hybridization using synthetic nanopore resistive pulse sensing
                  Is forensic science the last bastion of resistance against statistics?
                  DNA Commission of the International Society of Forensic Genetics: Recommendations on the Evaluation of STR Typing Results That May Include Drop-Out and/or Drop-In Using Probabilistic Methods
                  Modelling Heterozygote Balance in Forensic DNA Profiles
                  Analysis of Matches and Partial-Matches in a Danish STR Data Set
                  Interpreting Lineage Markers in View of Subpopulation Effects
                  Interpretation of Low Level DNA Mixtures
                  Consideration of the probative value of single donor 15-plex STR profiles in UK populations and its presentation in UK courts

  
Date Created: August 23, 2011
    
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