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                            Funding & Awards
 Bath Salt-type Aminoketone designer Drugs: Analytical and Synthetic Studies on Substituted Cathinones
Award Information
Awardee
              Auburn University
Award #
              2013-DN-BX-K022
Funding Category
              Competitive
Location
                    Auburn University, AL
Awardee County
              Lee
Congressional District
              3
Status
              Closed
Funding First Awarded
              2013
Total funding (to date)
              $344,325
Original Solicitation
              NIJ FY 13 Applied Research and Development in Forensic Science for Criminal Justice Purposes
Description of original award (Fiscal Year 2013, $344,325)
This project will address issues of resolution and discriminatory capabilities in controlled substance analysis providing additional reliability and selectivity for forensic evidence and analytical data on new analytes of the so-called bath salt-type drugs of abuse. A number of aminoketones or betaketo/benzylketo compounds (bk-amines) have appeared on the illicit drug market in recent years including methcathinone, mephedrone, methylone and MDPV (3,4-methylenedioxypyrovalerone). These substances represent a variety of aromatic ring substituent, hydrocarbon side chain and amino group modifications of the basic cathinone/methcathinone molecular skeleton. Exploration and designer development in the aminoketone drugs using models based on substituted amphetamines and related phenethylamines is likely to continue for many years. Current clandestine designer drug development concepts used for amphetamine-type molecules can be applied directly for aminoketone development. Clandestine production of these drugs can be based on common precursor chemicals. Therefore, legal control of the key precursor substance is not likely and would not prevent the further clandestine/designer exploration of this group of compounds. It could be argued that isomer differentiation is not necessary in forensic drug science because of the Controlled Substance Analog Act. However, the courts expect forensic drug chemistry to be able to identify a substance as an individual compound, not report it as an unknown member of a large group of isomeric substances. Furthermore, the forensic chemist must identify the compound in order to know if it is an analog of a controlled substance. These circumstances all point to the strong need for a thorough and systematic investigation of the forensic chemistry of these substituted aminoketones. The broad objective of this research is to improve the specificity, selectivity and reliability of the analytical methods used to identify ring substituted aminoketones and related compounds. This improvement will come from methods which allow the forensic analyst to identify specific regioisomeric forms of substituted aminoketones among many isomers of mass spectral equivalence. Mass spectrometry is the most common method of confirmation in forensic analysis. This project will provide methodology and analytical data to discriminate between those regioisomeric and isobaric molecules having the same molecular weight and major fragments of equivalent mass (i.e. identical mass spectra). Furthermore, this work will anticipate the future appearance of some designer aminoketones and develop analytical reference data and analytical reference standards for these compounds. The initial phase of this work is the organic synthesis of aminoketones of varying aromatic ring substituents, hydrocarbon side chains and amino groups. In this phase of the work more than 70 substituted aminoketones of potential forensic interest will be evaluated. The analytical phases will consist of chemical characterization, using tools common to forensic science labs such as MS and IR and these studies will be carried out on each of the compounds. The chromatographic retention properties for each series of isomers will be evaluated by gas and liquid chromatographic techniques on a variety of stationary phases. These studies will establish a structure-retention relationship for the regioisomers and isobaric aminoketones. When compounds exist which produce the same mass spectrum (same MW and fragments of equivalent mass) as the drug of interest, the identification by GC-MS must be based entirely upon the ability of the chromatographic system to resolve these substances. This project involves the synthesis and generation of complete analytical profiles as well as methods of differentiation for regioisomeric and isobaric substances related to the substituted aminoketones. 
ca/ncf



  
Grant-Funded Publications
        
                      Differentiation of the Six Dimethoxypyrovalerone Regioisomers: GC-MS, GC-MS/MS and GC-IR
                  GC-MS, GC-MS/MS and GC-IR Differentiation of Desoxy Cathinone Derivatives: Cyclic Tertiary Amines related to MDPV
                  GC-MS, GC-MS/MS and GC-IR differentiation of carbonyl modified analogues of MDPV
                  GC-MS, MS/MS and GC-IR Analysis of a Series of Methylenedioxyphenyl-Aminoketones: Precursors, Ring Regioisomers and Side-Chain Homologs of 3,4-Methylenedioxypyrovalerone
                  Differentiation of Homologous and Regioisomeric Methoxy-Cathinone Derivatives by GC-MS, MS/MS and GC-IR
                  Bath Salt-type Aminoketone Designer Drugs - Analytical and Synthetic Studies on Substituted Cathinones
                  Product Ion Tandem Mass Spectrometric Differentiation of Regioisomeric Side-Chain Groups in Cathinone Derivatives
                  Differentiation of Cyclic Tertiary Amine Cathinone Derivatives by Product Ion Electron Ionization Mass Spectrometry

  
Date Created: September 8, 2013
    
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