DRAFT Agenda

Federal Insecticide, Fungicide, and Rodenticide Act

Scientific Advisory Panel Meeting

January 31-February 2, 2012

Scientific Issues Associated with Common Effects Methodology developed by 

the Office of Pesticide Programs and the Office of Water

Docket number: EPA-HQ-OPP-2011-0898 OPP Docket Tel: 703-305-5805

Please note that all times are approximate 

(See note at the end of the Agenda)

Tuesday, January 31, 2012

9:00 A.M. Opening of Meeting and Administrative Procedures – Sharlene Matten, Ph.D. 

Designated Federal Official, Office of Science Coordination and Policy, EPA

9:05 A.M. Introduction and Identification of Panel Members – Janice Chambers, Ph.D., 

DABT, FIFRA Scientific Advisory Panel, Session Chair

9:15 A.M. Opening Remarks – Donald Brady, Director, Environmental Fate and Effects 

Division, Office of Pesticide Programs, EPA and Elizabeth Behl, Ph.D., Director, 

Office of Science and Technology, Office of Water, EPA

9:30 A.M. Introduction, Background, Status, and OPP and OW Data Requirements 

and Effects Characterizations – Kris Garber, Environmental Fate and Effects 

Division, Office of Pesticide Programs, EPA and Joe Beaman, Ph.D., Office of 

Science and Technology, Office of Water, EPA 

10:15 A.M. Break

10:30 A.M. Potential Use of Predictive Toxicology Tools in Characterizing Effects of 

Chemical Stressors to Aquatic Animals – Chris Russom, Ph.D., Mid-Continent 

Ecology Division, Office of Research and Development, EPA

11:00 A.M. Analysis of Sensitivity Distributions for Estimation of Acute Hazard 

Concentrations to Aquatic Animals – Matthew Etterson, Ph.D., Mid-Continent 

Ecology Division, Office of Research and Development, EPA

12:15 P.M. Lunch
2

1:15 P.M. Extrapolation Factors for Derivation of Acute Aquatic Life HC5s: Emphasis 

on Acetylcholinesterase Inhibitors – Russell Erickson, Ph.D., Mid-Continent 

Ecology Division, Office of Research and Development, EPA

2:15 P.M. Analysis of Chronic Toxicity Data and Acute Chronic Ratios (ACRs) in 

Support of Deriving Chronic HC5s: Acetylcholinesterase Inhibitors – David

Mount, Ph.D., Mid-Continent Ecology Division, Office of Research and 

Development, EPA

3:00 P.M. Break

3:15 P.M. Estimating Aquatic Plant Community Hazard Concentrations for Pesticide 

Effects – Glen Thursby, Ph.D., Atlantic Ecology Division, Office of Research and 

Development, EPA

5:00 P.M. Adjournment

Wednesday, February 1, 2012

9:00 A.M. Opening of Meeting and Administrative Procedures – Sharlene Matten, Ph.D., 

Designated Federal Official, Office of Science Coordination and Policy, EPA

9:05 A.M. Introduction and Identification of Panel Members – Janice Chambers, Ph.D., 

DABT, FIFRA Scientific Advisory Panel, Session Chair

9:10 A.M. Follow-up from Previous Day’s Meeting – Kris Garber, Ph.D., Office of 

Pesticide Programs, EPA

9:20 A.M. Public Comments 

10:30 A.M. Break

10:45 A.M. Charge Issue 1: Quantitative Structural Activity Relationship Models 

(QSARs) for Predicting Acute Toxicity for Aquatic Animals

12:00 P.M. Lunch

1:00 P.M. Charge Issue 2: Web-based Interspecies Correlation Estimation Models

(Web-ICE) for Predicting Acute Toxicity for Aquatic Animals

2:00 P.M. Charge Issue 3: Use of Species Sensitivity Distributions (SSDs) with Varying 

Amounts of Empirical Data of Estimate the HC5 (the 5-th Percentile of the 

SSD)

3:00 P.M. Break
3

3:15 P.M. Charge Issue 4: Extrapolation Factors for Estimating HC5 with a Specified 

Level of Confidence

4:30 P.M. Charge Issue 5: Use of Acute-Chronic Ratios (ACRs) to Estimate Chronic 

Toxicity Endpoints or HC5 Values for Acutely Sensitive Species 

5:30 P.M. Adjournment

Thursday, February 2, 2012

9:00 A.M. Opening of Meeting and Administrative Procedures – Sharlene Matten, Ph.D., 

Designated Federal Official, Office of Science Coordination and Policy, EPA

9:05 A.M. Introduction and Identification of Panel Members – Janice Chambers, Ph.D., 

DABT, FIFRA Scientific Advisory Panel, Session Chair

9:10 A.M. Follow-up From Previous Day’s Meeting – Kris Garber, Ph.D., Office of 

Pesticide Programs, EPA

9:20 A.M. Panel Discussion of Charge Question 5 cont’d

10:30 A.M. Break

10:45 A.M. Charge Issue 6: Estimating the HC5 for Aquatic Plants

12:30 P.M. Lunch

1:30 P.M. Continued Panel Discussion (as necessary)

3:00 P.M. Adjournment

Please be advised that agenda times are approximate; when the discussion for one topic is completed, 

discussions for the next topic will begin. For further information, please contact the Designated Federal 

Official for this meeting, Dr. Sharlene Matten, telephone: (202)-564-0130, fax: (202) 564-8382, or email: 

matten.sharlene@epa.gov.