81630 Federal Register / Vol. 75, No. 248 / Tuesday, December 28, 2010 / Notices 

development and differentiation in 

order to identify the critical stages 

where dysfunction can lead to the onset 

of breast cancer. 

• Molecular biology laboratory tool 

for sorting breast cancer positive and 

negative cells so that further 

comparative experiments can be 

performed to understand the cellular 

properties of the two sets of cells. 

Advantages: 

• Useful for in vitro and in vivo 

assays: Using the GFP or luciferase 

expression of these reporter plasmids, 

researchers can identify cells expressing 

various levels of GATA–3 and isolate 

these different subsets in vitro. These 

reporter constructs can also be 

transfected into cells to measure 

GATA–3 expression levels in vivo in 

real time from hematopoietic and breast 

cancer models. 

• Possible identification of new 

targets for breast cancer therapy: The 

reporter plasmids could be utilized to 

identify factors that serve to activate 

GATA–3 in normal mammary cells or 

inhibit GATA–3 expression in breast 

cancer cells. Such factors could serve as 

targets for novel breast cancer therapies. 

Inventors: Hosein Kouros-Mehr 

(formerly NCI) and Jeffrey E. Green 

(NCI) 

Selected Publications: 

1. H. Kouros-Mehr, et al. GATA–3 and 

the regulation of the mammary luminal 

cell fate. Curr Opin Cell Biol. 2008 

Apr;20(2):164–170. [PubMed: 18358709] 

2. H. Kouros-Mehr, et al. GATA–3 

links tumor differentiation and 

dissemination in the luminal breast 

cancer model. Cancer Cell 2008 

Feb;13(2):141–152. [PubMed: 18242514] 

3. H. Kouros-Mehr, et al. GATA–3 

maintains the differentiation of the 

luminal cell fate in the mammary gland. 

Cell 2006 Dec 1;127(5):1041–1055. 

[PubMed: 17129787] 

Patent Status: HHS Reference No. E– 

128–2009/0—Research Tool. Patent 

protection is not being pursued for this 

technology. 

Licensing Status: Available for 

licensing under a Biological Materials 

License Agreement. 

Licensing Contact: Samuel E. Bish, 

Ph.D.; 301–435–5282; 

bishse@mail.nih.gov. 

Dated: December 21, 2010. 

Richard U. Rodriguez, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. 2010–32671 Filed 12–27–10; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Biomedical 

Imaging and Bioengineering; Notice of 

Closed Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Biomedical Imaging and Bioengineering 

Special Emphasis Panel. 

Date: March 16–18, 2011. 

Time: 6 p.m. to 3 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Sheraton Fisherman’s Wharf Hotel, 

2500 Mason Street, San Francisco, CA 94133. 

Contact Person: Ruth Grossman, DDS, 

Scientific Review Officer, National Institute 

of Biomedical Imaging and Bioengineering, 

National Institutes of Health, 6707 

Democracy Boulevard, Room 960, Bethesda, 

MD 20892, 301–496–8775, 

grossmanrs@mail.nih.gov. 

Dated: December 16, 2010. 

Jennifer Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2010–32645 Filed 12–27–10; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Center for Scientific Review; Notice of 

Closed Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; Member 

Conflict: Cardiac Development. 

Date: January 4, 2011. 

Time: 3 p.m. to 4 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892. 

(Telephone Conference Call). 

Contact Person: Joseph Thomas Peterson, 

PhD, Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 4118, 

MSC 7814, Bethesda, MD 20892. 301–443– 

8130. 

This notice is being published less than 15 

days prior to the meeting due to the timing 

limitations imposed by the review and 

funding cycle. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.306, Comparative Medicine; 

93.333, Clinical Research, 93.306, 93.333, 

93.337, 93.393–93.396, 93.837–93.844, 

93.846–93.878, 93.892, 93.893, National 

Institutes of Health, HHS) 

Dated: December 21, 2010. 

Jennifer S. Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2010–32639 Filed 12–27–10; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Center for Scientific Review; Amended 

Notice of Meeting 

Notice is hereby given of a change in 

the meeting of the Center for Scientific 

Review Special Emphasis Panel, January 

6, 2011, 1 p.m. to January 6, 2011, 3:30 

p.m., National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892 

which was published in the Federal 

Register on December 16, 2010, 75 FR 

78719–78720. 

The meeting has been changed to an 

Internet Assisted Meeting (IAM). The 

meeting will be two days January 6, 

2011, 9 a.m. to January 7, 2011, 5 p.m. 

The meeting is closed to the public. 

Dated: December 21, 2010. 

Jennifer S. Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2010–32638 Filed 12–27–10; 8:45 am] 

BILLING CODE 4140–01–P 


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