### Appendix B. Table of Generic Data Requirements and Studies Used to Make the

**Reregistration Decision for Pyrethrins (PC 069001)** GUIDE TO APPENDIX B Appendix B contains a listing of data requirements which support the reregistration for active ingredients within the py rethrins case covered b y this RED. It contains generic data requirements that apply p yrethrins in all products, including data requirements for which a “ty pical formulation” is the test substance. The data table is organized in the following formats: 1. Data requirement (Column 1). The data requirements are listed in the order in which they

appear in 40 CFR 158. The reference numbers accompanying each test refer to the test protocols set in the Pesticide Assessment Gui dance, which is available from the National Technical Information Service, 5285 Port Royal Road, Springfield, VA 22161. (703) 487 - 4650. 2. Use Pattern (Column 2). This column indicates the use patterns for which the data requirements apply. The following letter designations are used for the given use patterns. A. Terrestrial food B. Terrestrial feed C. Terrestrial non- food D. Aquatic food E. Aquatic non- food outdoor F. Aquatic non- food industrial G. Aquatic non- food residential H. Greenhouse food I. Greenhouse non- food J. Forestry K. Res idential L. Indoor food M. Indoor non- food N. Indoor medical O. Indoor residential 3. Bibliographic Citation (Column 3). If the Agency has acceptable data in its files, this column lists the identifying number of each study . This normally is the Master Record Identification (MRID) number, but may be a “GS” number is no MRID number has been assigned. Refer to the Bibliography appendix for a complete citation of the study .**Data Requirement Use Patterns**  **Citations**

**New Guideline**  **Number Old** 

**Guideline Number**  **Descrip tion**  **PRODUCT CHEMISTRY** (unknown) 61 - 2 Description of Beginning Materials and Manufacturing Process All 43495201 (unknown) 61 - 3 Discussion of Formation of Im purities All 43495201 830.1550 61 - 1 Product Identity and Composition All 40836301, 41311201 , 41474601, 43495201 830.1600 61 - 2A Description of materials used to produce the product All 45923201, 41311201, 00161540, 41474601, 41474601, 00156652, 41365501, 44325201 830.1620 61 - 2B Description of production process Al 44245101, 45923201, 00161540, 41311201, 41474601, 41193901, 00156652, 41365501, 44325201 830.1670 61 - 2B Formation of Impurities All 40836301, 41311201, 41474601, 45923201, 41193901, 41365501, 44325201 830.1700 62 - 1 Preliminary Analysis All 41311201, 00165269, 41193901, 41365501, 4 4325201,40836302 830.1750 62 - 2 Certification of Limits All 40836302, 41311201, 41474601, 40836302 830.1800 62 - 3 Analytical Method All 40836301, 45923201, 41311202, 41474601,, 41193901, 41365501, 40836302 830.6302 63 - 2 Color All 40836303 , 45625306, 41311 203, 41474601, 41474601, 41193901, 41365501 830.6303 63 - 3 Physical State All 40836303, 40836303 45625306, 41311203, 41474601, 41193901, 45923201, 41365501 830.6304 63 -4 Odor All 40836303, 41311203, 41474601, 41474601, 45625306, 41193901, 41474601, 413 65501 830.6313 63 - 13 Stability to normal and elevated tem peratures, metals, and metal ions All 40836303, 42103901, 41311203 , 41193901, 41365501 830.7000 63 - 12 pH All 45625306, 41474601, 41474601, 45625306 830.7050 None UV/Visible Absorption All DATA GAP 830.7220 63 - 6 Boiling Point/boiling range All 40836303, 41311203,**Data Requirement Use Patterns**  **Citations**

**New Guideline**  **Number Old** 

**Guideline Number**  **Descrip tion**  41193901, 41365501 830.7300 63 - 7 Density All 40836303, 42103901, 45625306, 41474601, 41474601, 45625306, 41365501 830.7370 63 - 10 Dissociation Constants in Water All 41311203, 41193 901 830.7550 63 - 11 Partition coefficient, shake flask method All 40836303, 41311203, 41193901, 41365501 830.7840 63 - 8 Solubility All 40836303, 41311203, 41193901, 41365501 830.7860 63 - 8 Water solubility, generator column method All 40836303, 41311203, 4 1193901, 41365501 830.7950 63 - 9 Vapor Pressure All 40836303, 41311203, 41193901, 41365501 **ECOLOGICAL EFFECTS** 850.1010 72 - 2 Acute Toxicity to Freshwater Invertebrates A, B, C , K 43082305, 43082306 850.1025 72 - 3B Estuarine/Marine Toxicity

– Mollusk A, B, C , K 43082309, 43082310 850.1035 72 - 3C Estuarine/Marine Toxicity

– Shrimp A, B, C, K 43082311, 43082312 850.1045 72 - 3 Panaeid Acute Toxicity Test A, B, C, K 43082307, 43082308, 43082311, 43082312 850.1075 72 - 1A Fish Toxicity Bluegill A, B, C, K 43 082301, 43082302, 43082303, 43082304 850.1075 72 - 3A Estuarine/Marine Toxicity

– Fish A, B, C, K 43082307 43082308 850.1300 72 -4A Daphnid Chronic Toxicity Test A, B, C, K 43252701 850.1350 72 -4B Estuarine/Marine Invertebrate Life Cycle A, B, C, K 4325270 2, DATA GAP 850.1400 72 -4C Early- life Stage Freshwater Fish A, B, C, K 43252701, DATA GAP 850.2100 71 - 1A Avian Acute Oral Toxicity A, B, C, K 42010901 850.2200 71 - 2A Avian Dietary Toxicity

– Quail A, B, C, K 41968801, 41968802 850.3020 141 - 1 Honey bee acute contact LD50 A, B, C, K 41968803 Atkins et al., 1967 Stevenson, 1968 Stevenson, 1978 850.4100 122 - 1 Seedling Emergence, Tier 1 A, B, C, K DATA GAP 850.4150 122 - 1 Vegetative Vigor, Tier 1 A, B, C, K DATA GAP 850.4400 123 - 2 Aquatic Plant Toxicity A , B, C, K DATA GAP 850.5400 122 - 2B Aquatic Plant Growth, Tier 2 A, B, C, K DATA GAP NonGuideline Study NonGuideline Study Chronic Freshwater Sediment

Testing A, B, C, K DATA GAP NonGuideline Study NonGuideline Study Chronic Estuarine/Marine

Sediment Testing A, B, C, K DATA GAP **TOXICOLOGY** 870.1100 81 - 1 Acute Oral Toxicity - Rat A, B, C,H, I, K, L, M, O 42008101, 42599501,

263780**Data Requirement Use Patterns**  **Citations**

**New Guideline**  **Number Old** 

**Guideline Number**  **Descrip tion**  870.1200 81 - 2 Acute Dermal Toxicity

– Rabbit/Rat A, B, C,H, I, K, L, M, O 41964801 870.1300 81 - 3 Acute Inhalation Toxi city

– Rat A, B, C,H, I, K, L, M, O 4200800 1 , 870.2400 81 -4 Primary Eye Irritation - Rabbit A, B, C,H, I, K, L, M, O 41964802 870.2500 81 - 5 Primary Skin Irritation A, B, C,H, I, K, L, M, O 41964803 870.2600 81 - 6 Dermal Sensitization A, B, C,H, I, K, L, M, O 41964804 870.3200 82 - 2 21 - Day Dermal

– Rabbit/Rat A, B, C,H, I, K, L, M, O 42212601 870.3465 82 - 5 90 - Day Inhalation Toxicity A, B, C,H, I, K, L, M, O 42478201 870.3700A 83 - 3A Developmental Toxicity

– Rat A, B, C,H, I, K, L, M, O 40288202 870.3700B 83 - 3B Developmental Toxicity

– Rabbit A, B, C,H, I, K, L, M, O 40288203 870.3800 83 -4 2 - Generation Reproduction

– Rat A, B, C,H, I, K, L, M, O 41327501 870.4100A 83 - 1 Chronic Toxicity Rodents A, B, C,H, I, K, L, M, O 41559501 870.4100B 83 - 1B Chronic Feeding Toxicity Study - Non-rodent A, B, C,H, I, K, L, M, O 41496501 870.4200 83 - 2 Carcinogenicity - Rat A, B, C,H, I, K, L, M, O 41559501 870.4300 83 - 5 Com bined Chronic Toxicity/Carcinogenicity: Rats A, B, C,H, I, K, L, M, O 41559401 870 .5265 84 - 2 Gene Mutation Ames Assay A, B, C,H, I, K, L, M, O 41344701 870.5375 84 - 2 Cy togenetis

– CHO Chromosomal Aberrations A, B, C,H, I, K, L, M, O 41344601 , 43987001 870.5550 84 - 2 Unscheduled DNA Synthesis in Mammalian Cells in Culture A, B, C,H, I , K, L, M, O 41344501 870.6200 a 81 - 8 Acute neurotoxicity screen study in rats A, B, C,H, I, K, L, M, O 42925801 870.6300 83 - 6 Developmental Neurotoxicity Study A, B, C,H, I, K, L, M, O DATA GAP 870.7485 85 - 1 General Metabolism A, B, C,H, I, K, L , M, O 43554304, 43884101 Non- guideline Study Nonguideline Study Definitive Mechanistic Toxicity

Study in Rats A, B, C,H, I, K, L, M, O 45889802, 45889803 Non- guideline Study Nonguideline Study Toxicology: Cellular Changes in

Larynx A, B, C,H, I, K, L, M, O 46605701 Nonguideline Study Nonguideline Study Developmental Thyroid Assay A, B, C,H, I, K, L, M, O DATA GAP **ENVIRONMENTAL FATE** 835.1240 163 - 1 Leaching/Adsorption/Desorption A, B, C, K 43096603**Data Requirement Use Patterns**  **Citations**

**New Guideline**  **Number Old** 

**Guideline Number**  **Descrip tion**  835.1410 163 - 2 Laboratory Volatilization ( from Soil) Study A, B, C, K 43096604 850.1730 165 -4 Accumulation in Fish A, B, C, K 43302301, 43884102 835.2120 161 - 1 Hydrolysis A, B, C, K 43188201, 43567502, 835.2240 161 - 2 Photodegradation - Water A, B, C, K 43096601, 43567601 835.2410 161 - 3 Photo degradation - Soil A, B, C, K 43096602 835.4100 162 - 1 Aerobic Soil Metabolism A, B, C, K 43499803 835.4200 162 - 2 Anaerobic Soil Metabolism A, B, C, K 43499802 835.4300 162 -4 Aerobic Aquatic Metabolism A, B, C, K 43499801, 43499802 835.4400 162 - 3 Anaerobic Aquatic Metabolism A, B, C, K 43499801 835.6100 164 - 1 Terrestrial Field Dissipation A, B, C, K 42745501 835.6200 164 - 2 Aquatic Field Dissipation A, B, C, K 43818501, 43195201 **RESIDUE CHEMISTRY** 860.1300 171 -4A2 Nature of the Residue in Plants A, B, H 43554301, 43554302, 43554303, 43628402, 43668001, 45900802, 43628401, 860.1300 171 -4A3 Nature of the Residue in Livestock A, B, H 43628301, 43628302, 43833403, 43837601, 45900802 43837602, 860.1340 171 -4C Residue Analytical Method

– Plants A, B, H PAM Volume II , 43910601 860.1360 171 -4m Multiresidue Method A, B, H PAM Volume I

860.1380 171 -4E Plant commodities: (oilseeds, non oily grains, and root crops) A, B, H DATA GAPS 43232801, 43248701, 43292701, 43440001, 43470801, 43470802, 43470806, 441 26901, 45037101, 45037102, 45037103, 45037104, 45048001, 45256501, 45398401, 45900801 43440002, 43470801, 43470805, 44140401, 44140402, 43195201 860.1400 171 -4f Magnitude of the Residue - Water, Fish, and Irrigated Crops A, B, H 43195201 860.1460 171 -4 i Mag. of res. food handling A, B, H 42009801, 42009802, 42009803, 42009804, 42009805 860.1480 171 -4j Magnitude of the Residue - Meat, Milk, Poultry, Eggs A, B, H 43833401, 43833402 860.1500 171 -4K Crop field trials: Crop Groups 1, 2, 3, 4, 5, 6, 7, 8 , 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, and the following miscellaneous commodities: asparagus, atemoya, A, B, H DATA GAPS 107652, 43232801, 43248701, 43292701, 43298901, 4337080 1,**Data Requirement Use Patterns**  **Citations**

**New Guideline**  **Number Old** 

**Guideline Number**  **Descrip tion** 

avocado, banana, cacao bean, carob bean, cherimoya, coconut, coffee (green bean), cotton (seed and gin byproduct), cranberry, date, durian, fig, f lax, grape, guava, jojoba, kiwifruit, lychee, mango, mushroom, okra, papaya, peanut, persimmon, pomegranate, pineapple, safflower, straw berry, sugarcane, sunflower, tea, and tobacco 43440002, 43470805, 43470805, 43470806, 44249301, 45398401, 45900801

860.1520 171 -4L Magnitude of Residue in Processed Food/Feed: apple, barley, cacao bean, coconut, coffee, corn (field), cotton, fig, flax, oat, peanut, pineapple, plum, rice, rye, safflower, sorghum, soybean, sugarcane, sunflower, tea, and wheat A, B, H DATA GAPS 43470803, 45900801 43440001, 45900801 43470802, 45900801 43470804, 45900801, 43470801, 45900801 860.1850 165 - 1 Confined Accumulation in Rotational Crops A, B, H DATA GAP **OCCUPATIONAL AND RESIDENTIAL EXPOSURE** 840.1100 201 - 1 Spray Droplet Size Spectrum A, B, C, K SDTF 1 840.1200 202 - 1 Spray Drift Field Deposition A, B, C, K SDTF 875.1300 232 Inhalation Exposure L, M, O ORETF 2 875.1400 234 Inhalation Indoor Exposure

– Metered Release Device L, M, O DATA GAP 875.1400 234 Inhalation Indoor Exposure

– Ultra Lo w Volume Cold Fogger L, M, O DATA GAP 875.1700 none Product Use Information

– Metered Release Device L, M, O DATA GAP 875.2300 None Indoor Surface Residue Dissipatio n, Post application L, M, O 46188602, 46188613, 46188618, 46188623, 46188629 875.2400 133 - 3 Dermal Exposure

– Loading and application of dust A, B, C, K 44459801 875.2500 133 -4 Inhalation Exposure

– Outdoor Residential Misting System C, K 47062801 875. 2500 133 -4 Inhalation Exposure

– Fogging Data L, M, O 45869301 875.2500 133 -4 Inhalation Exposure

– Trigger Pum p Spray L, M, O 41054701 875.2500 133 -4 Inhalation Exposure

– Loading and Application of Dust A, B, C, K 44459801 **OTHER** Non- guideline Study N onguideline Study Incident Analysis All 46694701, 46694801, 46757301

1 Data owned by the Spray Drift Task Force. 2 Data owned by the Outdoor Residential Exposure Task Force.**Data Requirement Use Patterns**  **Citations**

**New Guideline**  **Number Old** 

**Guideline Number**  **Descrip tion**  Non- guideline Study Nonguideline Study Py

rethrins Stewardship Program All DATA GAP