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                            Funding & Awards
 Continued Development of FROG-kb: A Forensic Resource/Reference on Genetics knowledge base
Award Information
Awardee
              Yale University
Award #
              2014-DN-BX-K030
Funding Category
              Competitive
Location
                    New Haven, CT
Congressional District
              3
Status
              Closed
Funding First Awarded
              2014
Total funding (to date)
              $314,468
Original Solicitation
              NIJ FY 14 Research and Development in Forensic Science for Criminal Justice Purposes
Description of original award (Fiscal Year 2014, $314,468)
As submitted by the proposer: Forensic practice will be using single nucleotide polymorphisms (SNPs) in the near future to provide types of relevant information that the current forensic markers, short tandem repeat polymorphisms (STRPs), cannot provide--such as information on ancestry and visible traits such as hair, eye, and skin color. These applications require a large reference database on allele frequencies of SNPs in multiple populations around the world. The existing large database developed at Yale by Dr. K. Kidd and his group and the web interfaces ALFRED (Allele Frequency Database) and FROG-kb (Forensic Resource/Reference on Genetics knowledge base) that allow access to and forensic use of the data will be enhanced with more data and better functionality for use in forensic practice. The work over a two-year period will involve ongoing curation and entry of public data into the database. In addition, the web interfaces will have additional search and display functions as well as additional didactic information on the human population genetics and forensic principles aspects. Additional statistical ability will be incorporated into the FROG-kb interface. These improvements will facilitate the transition to use of SNPs in forensic practice and provide tools for their implementation. By the end of the project we anticipate a database of 100,000,000 allele frequency tables on nearly 1,000 different human populations with ready access and ability to use in practice the data most important for forensic practice. ca/ncf



  
Grant-Funded Publications
        
                      The distinctive geographic patterns of common pigmentation variants at the OCA2 gene
                  Ancestry Inference of 96 Population Samples Using Microhaplotypes
                  Selecting Microhaplotypes Optimized for Different Purposes
                  Continued Development of FROG-kb: A Forensic Resource/Reference on Genetics Knowledge Base
                  Evaluating 130 Microhaplotypes Across a Global Set of 83 Populations
                  Increasing the Reference Populations for the 55 AISNP Panel: the Need and Benefits
                  Minimal SNP Overlap Among Multiple Panels of Ancestry informative Markers Argues for More International Collaboration
                  Proposed Nomenclature for Microhaplotypes
                  52 Additional Reference Population Samples for the 55 AISNP Panel
                  Fighting Crime With Science
                                                                      NIJ Journal,

  
Date Created: September 11, 2014
    
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                      Accuracy, Efficacy, and Reproducibility of Muzzle-to-Target Distance Determination using Gunshot Residue
                  Analytical Challenges with Proliferating THC Analogues
                  New Age Therapeutics: Development and Validation of an Analytical Workflow for the Analysis of Psychedelics in Biological Matrices
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