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                            Funding & Awards
 Forensic Toxicological Screening/Confirmation of 500+ Designer Drugs by LC-QTOF-MS and LC-QqQ-MS Analysis
Award Information
Awardee
              The Florida International University Board of Trustees
Award #
              2014-R2-CX-K006
Funding Category
              Competitive
Location
                    Miami, FL
Congressional District
              26
Status
              Closed
Funding First Awarded
              2014
Total funding (to date)
              $396,970
Original Solicitation
              NIJ FY 14 Research and Development in Forensic Science for Criminal Justice Purposes
Description of original award (Fiscal Year 2014, $396,970)
As submitted by the proposer: "Designer drugs" (also known as "emerging drugs of abuse") are derivatives of controlled substances that are sold on the street in an attempt to circumvent the legal restrictions placed on scheduled drugs. For multiple reasons, these drugs present a major challenge to forensic toxicologists engaged in their detection and analysis and to clinicians involved in diagnosis and treatment of their effects in both acute overdose and chronic abuse scenarios. There are currently no validated analytical methods capable of screening and/or confirming a major portion of the universe of designer drugs in forensic specimens, or for detecting and characterizing novel, newly introduced drugs. With the ongoing rise in novel drug popularity and increasing reports of adverse health effects of designer drugs, there is a clear need within the forensic toxicology community for such methods. This two-year applied research project will investigate the use of low- and high-resolution mass spectrometric techniques, stand-alone or in combination, for comprehensive screening/confirmation of designer drugs in forensic specimens. Project goals include construction of a master drug database, a high-resolution, high-mass-accuracy MS spectral library, and a triggered MRM MS database for a minimum of 500 individual designer drug entities and metabolites from the cannabinoid and stimulant classes. Validated analytical methods will be developed using state-of-the-art LC-QqQ-MS and LC-QTOF-MS instrumentation. Research will also compare several specimen extraction methods and develop an optimized specimen processing approach for designer drugs. Finally, the validated extraction and analytical methods will be tested for screening/confirmation and unknown drug identification purposes using 400 authentic urine and 100 authentic whole blood specimens. The project goals will be facilitated by a partnership with a large, high-complexity drug testing laboratory located in South Florida, who will supply authentic specimens from employment and general drug screening, physician offices, drug rehabilitation programs, and other compliance/monitoring purposes. Results of this project will be disseminated through interim and final progress reports prepared for the sponsor, reports prepared for third party entities, and presentation of data at national and international forensic science conferences and in peer-reviewed forensic/toxicology journals. It is anticipated that successful achievement of the project goals will provide working forensic toxicology labs with valuable tools for analysis of this important class of drugs, in addition to shedding light on the prevalence of designer drugs in forensic specimens obtained from the general user population.
ca/ncf



  
Grant-Funded Publications
        
                      Forensic Toxicological Screening/Confirmation of 500+ Designer Drugs by LC-QTOF-MS and LC-QqQ-MS Analysis
                  Separation and Identification of Isomeric and Structurally Related Synthetic Cannabinoids Using 2D Liquid Chromatography and High Resolution Mass Spectrometry
                  Systematic analysis of novel psychoactive substances. II. Development of a screening/confirmatory LC-QqQ-MS/MS method for 800

  
Date Created: September 11, 2014
    
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