Employment Agreement effective as of March 16, 2010



 Exhibit 10.16 
 Portions of this exhibit marked [*] are requested to be treated confidentially. 
 EMPLOYMENT AGREEMENT 
 THIS EMPLOYMENT AGREEMENT (the
“Agreement”), is made and entered into on this 2nd day of February, 2010, to be effective on the 16th day of March, 2010 (the “Effective Date”), by and between PPD Therapeutics, Inc., a Delaware corporation (the “Company”), with its principal place of business in North
Carolina and currently with a mailing address for notice purposes of 929 North Front Street, Wilmington, North Carolina 28401, Attention: Chairman of the Board, and June S. Almenoff, MD, PhD (“Employee”), an individual whose mailing
address for notice purposes is 2804 Trail Wood Drive, Durham, North Carolina 27705. 
 RECITALS 
 A. Before Employee and the Company entered into this Agreement, Pharmaceutical Product Development, Inc. (“PPDI”) announced its
plan to spin off its compound partnering business into a separate, publicly-traded entity (the “Spin-Off”). 
 B. The
Company is a wholly-owned subsidiary of PPDI and was formed for the purpose of owning and operating PPDI’s compound partnering business prior to and after the Spin-Off. 
 C. PPDI and the Company currently anticipate that the Spin-Off will be accomplished through a pro rata dividend of all of the common stock
of the Company to the shareholders of PPDI and will be completed by mid-2010. 
 D. The Company desires to employ Employee and
Employee desires to be employed by the Company, all upon the terms and conditions set forth herein. 
 NOW, THEREFORE, in
consideration of the foregoing recitals, the mutual covenants of the parties hereinafter set forth and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows:

 ARTICLE 1 
 EMPLOYMENT AND DUTIES 
 1.1 Employment of Employee. On the Effective Date, the Company agrees to employ
Employee and Employee accepts such employment pursuant and subject to the terms and conditions of this Agreement. 
 1.2
Duties and Powers. During the Employment Period (as defined herein), Employee shall serve as President and Chief Medical Officer of the Company and will have such responsibilities, duties and authority, and will render such services for and
in connection with the Company and its affiliates as are customary in such position and as the Board of Directors of the Company (the “Board”) or the Chief Executive Officer shall from time to time reasonably direct. Employee shall devote
Employee’s full business time and attention exclusively to the Business of the Company and shall use best efforts to faithfully carry out Employee’s duties and responsibilities hereunder. Employee shall comply with all personnel policies
and procedures of








 
the Company as the same now exist or may be hereafter implemented by the Company from time to time, including those policies contained in the Company’s employee manual or handbook which sets
forth policies and procedures generally for employees of the Company and its current or future subsidiaries (the “Handbook”) to the extent not inconsistent with this Agreement. 
 ARTICLE 2 
 TERM OF EMPLOYMENT 
 Unless sooner terminated as provided elsewhere in this Agreement, Employee’s employment under this Agreement shall begin on the
Effective Date and end on the first anniversary thereof (“Initial Employment Period”). After the Initial Employment Period, this Agreement shall automatically renew for successive one-year periods, unless either the Company or Employee
provides written notice to the other at least ninety (90) days prior to the termination of the Initial Employment Period or any renewal period stating said party’s desire to terminate this Agreement. The Initial Employment Period and any
extension or renewal thereof shall be referred to herein together as the “Employment Period”. Notwithstanding anything to the contrary contained herein, the Employment Period is subject to termination pursuant to Article 4 hereof.

 ARTICLE 3 
 COMPENSATION AND BENEFITS 
 3.1 Base Salary. During the Employment Period, the Company will pay Employee
an annual base salary at a rate of $350,000.00 per annum (the “Base Salary”), payable in accordance with the Company’s regular payroll policy for salaried employees. The Base Salary of Employee may be subject to periodic review and
adjustment by the Company during the Employment Period, but shall not be reduced below $350,000 unless such reduction is part of a widespread reduction of executive salaries. If the Employment Period is terminated pursuant to Article 4 hereof or is
otherwise shorter than a full contract year, then the Base Salary for any partial year will be prorated based on the number of days elapsed in such year during which services were actually performed by Employee. 
 3.2 Benefits. 
 a. From the Effective Date until the Spin-Off is complete, during the Employment Period, Employee will be entitled to participate in the group health insurance and other benefits offered by PPDI and
available to Company employees, subject to Employee meeting the eligibility requirements for such PPDI plans and benefits. After the Spin-Off, during the Employment Period, Employee will no longer be entitled to participate in the PPDI plans and
benefits, but will be entitled to participate in the Company’s plans and benefits as such plans and benefits are maintained from time to time by the Company, subject again to Employee meeting the applicable eligibility criteria therefor.
Nothing in this Agreement will be interpreted to alter PPDI’s or the Company’s right to amend, modify or terminate any such plans and benefits in its discretion from time to time. 
  

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 b. During the Employment Period, Employee will be entitled to twenty-seven
(27) days of Paid Time Off (“PTO”), exclusive of paid holidays, each calendar year. Employee shall be allowed to carry over up to seven (7) days of unused PTO from one calendar year to the next. Upon termination of employment,
Employee shall be paid for all accrued unused PTO. Except where inconsistent with this Agreement, PTO shall be subject to the provisions of the Company’s Handbook or any other written policy of the Company on PTO. 
 c. In addition to the benefits provided in (a) and (b), above, during the Employment Period, Employee will be eligible
to participate in the Company’s discretionary annual cash incentive plan (the “Cash Incentive Plan”), once adopted and established by the Company’s Board or a committee thereof. Subject to the Company establishing and
implementing the Cash Incentive Plan, the Company anticipates that the target bonus for Employee’s position in 2010 will be fifty percent (50 %) of Employee’s Base Salary earned in that calendar year. Awards under the Cash Incentive Plan,
if any, will be based upon both the Company’s achievement of its corporate and financial goals and Employee’s individual performance, and are entirely at the Company’s discretion. To receive any award under the Cash Incentive Plan,
Employee must be actively employed by the Company on the date payments are made under the Cash Incentive Plan. 
 d. Company shall pay for continuing medical education for Employee up to three days per calendar year and will pay fees associated with maintaining Employee’s medical license and Fellowship status in the American College of Physicians.
Company will also pay for Employee to attend a reasonable amount of training annually, in business, finance and corporate governance. 
 3.3 Equity Compensation. Subject to the adoption of an equity compensation plan by the Company’s Board (the “Equity Plan”), Employee shall be eligible to participate in the Equity Plan during the Employment Period.
Subject to the approval by the Company’s Board or committee thereof and limitations under applicable law, the Company shall grant to Employee incentive options to purchase shares equal to (a) not less than 1.333 percent of the
Company’s outstanding common stock on or before the expiration of the 60-day period following the Spin-Off (the “Initial Option Grant”) and (b) subject to the performance of the Company and the Employee, not less than 0.667
percent of the Company’s outstanding common stock on or about the second anniversary of the Spin-Off (the “Subsequent Option Grant”). The Initial Option Grant and the Subsequent Option Grant shall be subject to the terms and
conditions of the Equity Plan and such other stock option award agreements and/or terms and conditions as the Company’s Board shall require. In addition, the Initial Option Grant and the Subsequent Option Grant shall be subject to a three year
linear vesting schedule under which one-third of the total number of options granted under the Initial Option Grant shall vest on each of the first, second and third anniversaries of the Effective Date and one-third of the total number of options
under the Subsequent Option Grant shall vest on each of the first, second and third anniversaries of the date of the grant thereof. The Initial Option Grant and the Subsequent Option Grant shall have an exercise price based on the fair market value
of the Company’s common stock on the date of grant as measured in the manner established by the Company’s Board or committee thereof. 
  

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 3.4 Expenses. During the Employment Period, the Company will reimburse Employee, in
accordance with and subject to Employee’s compliance with the Company’s policy, for Employee’s necessary and reasonable out-of-pocket expenses incurred in the course of performance of Employee’s duties hereunder. All
reimbursement of expenses to Employee hereunder shall be conditioned upon Employee’s presentation of timely and sufficient documentation evidencing such expenses, in accordance with the Company’s policies and procedures on business expense
reimbursement. 
 3.5 Working Facilities. Employee shall work out of the Company’s principal offices in Morrisville,
North Carolina. The Company shall furnish Employee with such enclosed office space, equipment, technical, secretarial and clerical assistance and such other facilities, services and supplies as shall be reasonably necessary to enable Employee to
perform the duties required of Employee hereunder in an efficient and professional manner. 
 3.6 Sign-On Bonus. The
Company will pay Employee a one-time bonus of $75,000 in cash within thirty (30) days of the Effective Date in accordance with the terms of a separate sign-on bonus agreement to be entered into simultaneously with this Agreement. 
 ARTICLE 4 
 TERMINATION OF EMPLOYMENT 
 4.1 Basis for Termination. Notwithstanding any other provision in this
Agreement to the contrary, the Employment Period and Employee’s employment hereunder shall terminate effective on the date indicated upon the happening of any of the following events: 
 a. Upon the death of Employee, effective immediately on the date of death without any notice; 
 b. Upon a determination by the Chief Executive Officer or, if this office is vacant, the Board (other than Employee, if
Employee is then serving on the Board), acting in good faith and not in an arbitrary or capricious manner, but made in his or its sole discretion, that Employee has become physically or mentally incapacitated, as determined under the Company’s
short-term disability policy, and is unable to perform her duties under this Agreement as a result of such disability, which inability continues for a period of ninety (90) days during any twelve-month period hereunder, effective upon the date
said determination is communicated to Employee or such later date as specified by the Chief Executive Officer or the Board, as applicable; or 
 c. Upon a determination by the Chief Executive Officer or, if this office is vacant, the Board (other than Employee, if Employee is then serving on the Board), acting in good faith but made in his or its
sole discretion, that Employee: (i) deliberately failed to substantially perform Employee’s duties and responsibilities for the Company and/or committed a material violation of any Company policy or procedure (including without limitation
any policy or procedure described in the Handbook); (ii) willfully or intentionally engaged in any act or omission that materially injures, or, in the opinion of the Board, has the capacity to materially injure, the business or reputation of
the Company, including but not limited to injury to any director, employee, client or

  

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shareholder of the Company; (iii) demonstrated willful misconduct in Employee’s execution of duties for the Company (including but not limited to insubordination); (iv) engaged in
a form of discrimination or harassment prohibited by law (including, without limitation, discrimination or harassment based on race, color, religion, sex, national origin, age, disability, and/or genetic information); (v) misappropriated or
embezzled material tangible or intangible property of the Company; (vi) materially breached the terms of this Agreement and/or any other written agreement between Employee and the Company; and/or (vii) has been convicted of or pleaded
guilty or no contest to a felony. 
 d. Upon 30 days notice, either Employee or Company may terminate employment.
A termination pursuant to this Section shall be considered termination without cause. 
 4.2 Compensation After Termination
Pursuant to 4.1(a)-(c). If the Company terminates Employee’s employment during the Employment Period pursuant to Section 4.1(a) through (c) hereof, then the Company shall have no further obligations hereunder or otherwise with
respect to Employee’s employment from and after Employee’s termination, except that the Company shall pay Employee’s Base Salary accrued through the date of her termination on the next regularly scheduled payroll period that follows
the termination and shall provide such benefits as are required by applicable law. From and after such termination, the Company shall continue to have all other rights available hereunder, including without limitation all rights under the
Proprietary Agreement and/or the Non-Competition Agreement (as hereinafter defined) and attached hereto as Annex A and Annex B, respectively. 
 4.3 Compensation After Termination by the Company Pursuant to 4.1(d) or Non-renewal Pursuant to Section 2. If the Company terminates Employee’s employment during the Employment Period
pursuant to Section 4.1(d) or if the Company terminates Employee’s employment as a result of giving notice of non-renewal pursuant to Section 2, then Employee shall be entitled to the following compensation and benefits set forth in
Sections 4.3(a), (b), (c) and (d); provided, however, that the payments under Sections 4.3(b) and (c) are subject to Employee’s execution and delivery of a full General Release of all claims against the Company within sixty
(60) days of Employee’s termination and the expiration of any applicable revocation period: 
 a. Base
Salary accrued through the date of termination to be paid on the Company’s next usual and customary payroll date following her termination. 
 b. Severance pay equal to 12 months of Base Salary based on the rate of Base Salary as of Employee’s termination to be paid over the remaining period in the calendar year of Employee’s
termination; provided if the termination is in November the severance will be paid over four months following termination, and if the termination is in December (or if the Company provides notice of termination in December), the severance will be
paid over three months following termination. Such severance pay will be paid under the following conditions: 
 i. Payments shall not begin until such General Release has been executed and delivered and the revocation period has expired; and 
  

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 ii. Payments shall be made in installments at the same time as Base Salary
would have been paid if the Employee had not terminated, except that any payments that would be due for the period following termination and before the General Release (and the expiration of the revocation period) has been given shall be paid in a
single lump sum, and any remaining payments that are unpaid as of March 15 of the calendar year following involuntary termination of Employee shall be accelerated and paid in a lump sum on such March 15. The severance payments described in
this paragraph are intended to qualify as short-term deferrals meeting the requirements of Treas. Reg. § 1.409A-1(b)(4), and this paragraph shall be construed in accordance with such intent. 
 c. Payment of the monthly COBRA premium for continuation of group health and dental coverage for Employee and her dependents,
for each of the 12 months immediately following Employee’s termination. The medical and dental coverage provided hereunder is intended to constitute a portion of the COBRA continuation coverage for Employee and Employee’s dependents, but
such coverage will not cause their COBRA continuation periods to end prior to the end of their otherwise applicable period of COBRA continuation coverage. 
 d. Notwithstanding anything to the contrary herein or in any agreement evidencing the Initial Option Grant, the options subject to the Initial Option Grant that are not vested at the end of
Employee’s employment with the Company, if any, shall continue to vest in accordance with the vesting schedule under the Initial Option Grant during the 12-month period immediately following the end of Employee’s employment, at which time
all remaining unvested options under the Initial Option Grant, if any, shall terminate. Employee shall have three months following the expiration of such 12-month period in which to exercise any vested options under the Initial Stock Grant. The
Company shall cause the provisions of this Section 4.3(d) to be included in the terms of the Initial Option Grant. 
 The provisions of
Section 4.3 shall survive the Company’s non-renewal of this Agreement pursuant to Section 2. From and after such termination or end of employment due to non-renewal, the Company shall continue to have all other rights available
hereunder, including without limitation all rights under the Proprietary Agreement and/or the Non-Competition Agreement (as hereinafter defined) and attached hereto as Annex A and Annex B, respectively. 
 4.4 Resignation as Officer and Director. Upon the end of Employee’s employment, Employee will also be deemed to have resigned
her position(s), if any, as an officer or director of the Company, as a member of any Board committees, as well as any other positions she may hold with or for the benefit of the Company and/or its affiliates. 
 ARTICLE 5 
 PROPRIETARY INFORMATION 
 Prior to or coincident with the Effective Date, Employee shall execute and deliver to
the Company its standard Proprietary Information and Inventions Agreement (the “Proprietary Agreement”), a copy of which is attached hereto as Annex A. 
  


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 ARTICLE 6 
 NON-COMPETITION AND NON-SOLICITATION 
 Prior to or coincident with the
Effective Date, Employee shall execute and deliver to the Company its standard Non-Competition and Non-Solicitation Agreement (the “Non-Competition Agreement”), a copy of which is attached hereto as Annex B. 
 ARTICLE 7 
 MISCELLANEOUS 
 7.1 Withholding Taxes. All amounts payable under this Agreement, whether such payment is
to be made in cash or other property, shall be subject to applicable withholding requirements for Federal, state and local income taxes, employment and payroll taxes, and other legally required withholding taxes and contributions to the extent
appropriate in the determination of the Company, and Employee shall report all such amounts as income on Employee’s personal income returns and for all other purposes. 
 7.2 Assignment. No party hereto may assign or delegate any of its rights or obligations hereunder; provided, however, that the
Company shall have the right to assign all or any part of its rights and obligations under this Agreement (i) to any member, subsidiary or affiliate of the Company or any surviving entity following any merger or consolidation of any of those
entities with any entity other than the Company, or (ii) in connection with the sale of all or substantially all of the Company’s assets. 
 7.3 Binding Effect. All covenants and agreements contained in this Agreement by or on behalf of any of the parties hereto shall be binding upon and inure to the benefit of the respective legal
representatives, heirs, successors and permitted assigns of the parties hereto. 
 7.4 Entire Agreement. This Agreement
(including the Proprietary Agreement and Non-Competition Agreement attached hereto as Annexes A and B) and the Severance Agreement set forth the entire understanding of the parties and supersedes and preempts all prior oral or written
understandings and agreements with respect to the subject matter hereof. 
 7.5 Severability. Whenever possible, each
provision of this Agreement shall be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be prohibited by or invalid under applicable law, such provision shall be
ineffective only to the extent of such prohibition or invalidity, without invalidating the remainder of this Agreement. 
 7.6
Amendment; Modification. No amendment or modification of this Agreement and no waiver by any party of the breach of any covenant contained herein shall be binding unless executed in writing by the party against whom enforcement of such
amendment, modification or waiver is sought. No waiver shall be deemed a continuing waiver or a waiver in respect of any subsequent breach or default, either of a similar or different nature, unless expressly so stated in writing. 
  

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 7.7 Governing Law. This Agreement shall be governed by and construed and enforced in
accordance with the laws of the State of North Carolina, without giving effect to provisions thereof regarding conflict of laws. 
 7.8 Arbitration. Except for disputes, controversies or claims arising out of or related to the Proprietary Agreement, the Non-Competition Agreement (attached as Annex A and B) and/or a benefit plan governed by the
Employee Retirement Income Security Act, any dispute, controversy or claim arising out of or relating to this Agreement, including but not limited to its existence, validity, interpretation, performance or non-performance or breach, shall be decided
by a single neutral arbitrator agreed upon by the parties hereto in Raleigh, North Carolina in binding arbitration pursuant to the commercial arbitration rules of the American Arbitration Association then in effect. The parties to any such
arbitration shall be limited to the parties to this Agreement or any successor thereof. The written decision of the arbitrator shall be final and binding and may be entered and enforced in any court of competent jurisdiction. Each party waives any
right to a jury trial in any such forum. Each party to the arbitration shall pay its fees and expenses, unless otherwise determined by the arbitrator. 
 7.9 Notices. All notices, demands or other communications to be given or delivered hereunder or by reason of the provisions of this Agreement shall be in writing and shall be deemed to have been
properly served if (a) delivered personally, (b) delivered by a recognized overnight courier service, (c) sent by certified mail, return receipt requested and first class postage prepaid, or (d) sent by facsimile transmission
followed by a confirmation copy delivered by a recognized overnight courier service the next day. Such notices, demands and other communications shall be sent to the address first set forth above, or to such other address or to the attention of such
other person as the recipient party has specified by prior written notice to the sending party. Date of service of such notice shall be (i) the date such notice is personally delivered or sent by facsimile transmission (with issuance by the
transmitting machine of a confirmation of successful transmission), (ii) the date of receipt if sent by certified mail, or (iii) the date of receipt if sent by overnight courier. 
 7.10 Counterparts. This Agreement may be executed in multiple counterparts, each of which shall be deemed an original and all of
which taken together shall constitute one and the same agreement. 
 7.11 Descriptive Heading; Interpretation. The
descriptive headings in this Agreement are inserted for convenience of reference only and are not intended to be part of or to affect the meaning or interpretation of this Agreement. 
 7.12 Section 409A Compliance. The parties hereto intend that this Agreement comply with Section 409A of the Code and all
guidance or regulations thereunder (“Section 409A”), including compliance with all applicable exemptions from Section 409A (e.g., the short-term deferral exception). The parties hereby agree that this Agreement shall at all times be
construed in a manner to comply with Section 409A and that should any provision be found not in compliance with Section 409A, the parties are hereby contractually obligated to execute any and

  

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all amendments to this Agreement required to achieve compliance with Section 409A. In the event amendments are required to be made to this Agreement to comply with Section 409A, the
Company shall use its commercially reasonable best efforts to provide the Employee with substantially the same benefits and payments she would have been entitled to pursuant to this Agreement had Section 409A not applied, but in a manner that
is compliant with Section 409A. The manner in which the immediately preceding sentence shall be implemented shall be the subject of good faith negotiations of the parties. 
 7.13 Rules Applicable to Reimbursements or In-Kind Benefits. All reimbursements or in-kind benefits shall be provided in accordance
with the rules of this Section 7.13. The amount of expenses eligible for reimbursement, or in-kind benefits provided, during Employee’s taxable year may not affect the expenses eligible for reimbursement, or in-kind benefits to be
provided, in any other taxable year. The reimbursement of an eligible expense must be made on or before the last day of Employee’s taxable year following the taxable year in which the expense was incurred. Employee’s right to reimbursement
or in-kind benefits may not be liquidated or exchanged for another benefit. To the extent there is a conflict between this Section 7.13 and any other Section of this Agreement, the terms of this Section shall prevail. 
 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year first above written. 
  

					
	COMPANY:	 	PPD THERAPEUTICS, INC.
			
		 	By:	 	 
		 	Name: 	 	 
		 	Title	 	 
		
	EMPLOYEE:    	 	 
		 	June S. Almenoff, MD, PhD


  

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 ANNEX A 
 PROPRIETARY INFORMATION 
 AND INVENTIONS AGREEMENT

 In consideration and as a condition of my employment by PPD Therapeutics, Inc., a Delaware corporation with its principal
place of business in Wake County, North Carolina, or any affiliate, subsidiary, successor or assigns, as the case may be (collectively referred to herein as the “Company”), I hereby agree as follows: 
 1. “Proprietary Information” is information that was or is developed by, became or becomes known by, or was or is assigned or
otherwise conveyed to the Company, and which has commercial value in the Company’s business. Proprietary Information includes, without limitation, trade secrets, financial information, product plans, customer lists, marketing plans and
strategies, systems, manuals, forecasts and other business information, improvements, inventions, business strategies, business methods and practices, formulas, product ideas, biological material and techniques for their handling and use, chemical
and/or information analysis and related products and data, computer programs and software, software designs and documentation, source codes, algorithms, techniques, schematics, know-how and data, and any other confidential or proprietary information
of the Company or its customers or clients which I have been, or may be exposed to, or have learned or may learn of from time to time in connection with or as a result of my capacity as an employee of or consultant to the Company, including during
the term of this Agreement. Proprietary Information shall not include information that is, through no improper action or inaction by me, generally available to the public. I understand that my employment creates a relationship of confidence and
trust between me and the Company with respect to Proprietary Information of the Company or its customers which may be learned by me during the period of my employment. 
 2. In consideration of my employment by the Company and the compensation received by me from the Company from time to time, I hereby agree as follows: 
 (a) All Proprietary Information and all patents, copyrights, trade secret rights and other rights (including throughout,
without limitation, any extensions, renewals, continuations or divisions of any of the foregoing) in connection therewith shall be the sole property of the Company. I hereby assign to the Company any rights I may have or acquire in such Proprietary
Information. At all times, both during my employment by the Company and after its termination, I will keep in confidence and trust and will not use or disclose any Proprietary Information or anything relating to it without the written consent of the
Company, except as may be necessary in the ordinary course of performing my duties to the Company. 
 (b) In the
event of the termination of my employment by me or by the Company for any reason, I shall return all documents, records, apparatus, equipment and other physical property, or any reproduction of such property, whether or not pertaining to Proprietary
Information, furnished to me by the Company or produced by myself or others in connection with my employment, to the Company immediately as and when requested by the Company. 







 (c) I will promptly disclose to the Company, or any persons designated by
it, all “Inventions”, which includes all improvements, inventions, formulas, ideas, works of authorship, processes, computer programs and software, software designs and documentation, algorithms, techniques, schematics, know-how data,
whether or not patentable, made or conceived or reduced to practice or developed by me, either alone or jointly with others, during the term of my employment and for six (6) months thereafter. To the extent the Company does not have rights
therein hereunder, such disclosure shall be received by the Company in confidence and does not extend the assignment made in Section (d) below. 
 (d) I agree that all Inventions which I make, conceive, reduce to practice or develop (in whole or in part, either alone or jointly with others) during my employment shall be the sole property of the
Company to the maximum extent permitted by law, and, to the extent permitted by law, shall be “works made for hire”. The Company shall be the sole owner of all patents, copyrights, trade secret rights, and other intellectual property or
other rights in connection therewith. I hereby assign to the Company any rights I may have or acquire in such Inventions. I agree to perform, during and after my employment, all acts deemed necessary or desirable by the Company to permit and assist
it, at the Company’s expense, in obtaining and enforcing patents, copyrights, trade secret rights or other rights on such Inventions and/or any other Inventions I have or may at any time assign to the Company in any and all countries. Such acts
may include, but are not limited to, execution of documents and assistance or cooperation in legal proceedings. With respect to any and all matters arising out of or relating to my employment or consultancy with the Company, I hereby irrevocably
designate and appoint the Company and its duly authorized officers and agents, as my agents and attorneys-in-fact to act for and in my behalf and instead of me, to execute and file any applications or related filings and do all other lawfully
permitted acts to further the prosecution and issuance of patents, copyrights, trade secret rights or other rights thereon with the same legal force and effect as if executed by me. 
 (e) I attach hereto a complete list of all Inventions or improvements to which I claim ownership and/or that I desire to
remove from the operation of this Agreement, and I covenant that such list is complete. If no such list is attached to this Agreement, I represent that I have no such Inventions and improvements at the time of signing this Agreement. I understand
that any such list shall not contain information that breaches an obligation of confidentiality with a former employer. 
 (f) I represent that my performance of all the terms of this Agreement will not breach any agreement or obligation to keep in confidence proprietary information acquired by me in confidence or in trust prior to my employment by the Company.
I have not entered into, and I agree I will not enter into, any agreement either written or oral in conflict herewith or in conflict with my employment with the Company. 
 3. The Company agrees that it will not request as part of my employment that I divulge or make use of proprietary information of any of my former employers that has commercial value to the former employer
who developed such information. 
  

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 4. I acknowledge that in the event of my breach or threatened breach of the terms of this
Agreement, the Company shall not have an adequate remedy at law and shall, in addition to any other available rights and remedies, have the right to obtain injunctive relief, including without limitation specific performance. 
 5. This Agreement shall be effective as of the first day of my employment by the Company, and shall be binding upon me, my heirs, executors,
assigns, and administrators, and shall inure to the benefit of the Company and any current and future affiliates, subsidiaries, successors and assigns. This Agreement supersedes any agreement which may have been previously made or executed by me
relating to this matter. This Agreement shall be governed by the laws of the State of North Carolina (exclusive of conflicts of law provisions), which shall be the venue for resolution of any dispute related to this Agreement. This Agreement or any
part thereof shall not be modified, amended, or waived except by the written consent of the Company’s Chief Executive Officer or other duly authorized officer. 
  

					
	Dated:	 	                    
        , 20        
		
		 	 
		 	Name: June S. Almenoff, MD, PhD
	
	Accepted and Agreed to:
		
		 	PPD Therapeutics, Inc.
			
		 	By:	 	 
		 	Name:	 	 
		 	Title:	 	 

  

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 ANNEX B 
 NON-COMPETITION 
 AND NON-SOLICITATION AGREEMENT 

 THIS AGREEMENT is made this          day of
                        , 20__, by and between PPD Therapeutics, Inc., a Delaware corporation with its principal place in
North Carolina (the “Company”), and June S. Almenoff, MD, PhD, an individual whose address is 2804 Trail Wood Drive, Durham, North Carolina 27705 (herein referred to as “Employee”). 
 RECITALS 
 A. The Company is engaged in the business of developing and commercializing, directly and with third parties, potential drug candidates and drug products in various therapeutic areas (the “Business”). 
 B. Employee will perform a highly responsible role in the Company’s organization, have specialized knowledge of the Company’s
Business, existing and future potential drug candidates and drug products, and trade secrets and proprietary information, and have contact with or knowledge of the Company’s employees and contractors. 
 C. The Company and Employee agree that because of the knowledge, information and relationships to which Employee will be exposed during the
course of Employee’s employment with the Company, it would be harmful to the Company for Employee to compete with the Company or solicit its employees or contractors in the manner prohibited by this Agreement and that the Company has a
legitimate business interest in protecting itself from such competition and solicitation. 
 NOW, THEREFORE, in consideration of
the foregoing and the mutual promises herein contained and other valuable consideration detailed below, the parties agree as follows: 
 1. Restrictive Covenants. In order to protect, among other things, the Company’s business interests, its investments in its drug candidates, drug products, trade secrets and proprietary information, its relationships with its
employees and contractors, and its goodwill, Employee agrees to the following covenants and restrictions: 
 1.1
Non-Competition Agreement. During employment with the Company and (a) if employment ends in the first [*] of employment, for a period of [*] after termination of employment with the Company, or (b) if employment ends after the first
[*] of employment, for a period of [*] after termination of employment with the Company (the “Non-Compete Restricted Period”), Employee will not, directly or indirectly, participate or engage in any business or activity that competes with
the Business of the Company in the Territory (as defined below) in any capacity whatsoever, whether as an individual on his or her own account or as an employee, consultant, contractor, officer, director, shareholder, partner, member, joint
venturer, representative, 
 [*] Confidential treatment requested; certain information omitted and filed separately with the SEC.








 agent or equity owner of any business entity. Notwithstanding the foregoing, nothing in this
Agreement is intended to prohibit Employee from: 
 (a) being employed by or providing any services to a
pharmaceutical, biotechnology, medical device or other business entity so long as Employee does not perform any work or consulting services for any such entity that, directly or indirectly, relates to any drug candidates or drug products that
compete with any drug candidates or drug products that are then being, or are proposed to be, developed, produced, manufactured, commercialized, provided or marketed by, under or through the Company, any collaborator or licensee of the Company, or
other third party under or pursuant to any agreement or arrangement with the Company, or its or their successors or assigns. For purpose of this Agreement, drug candidates or drug products that are proposed to be developed, produced, manufactured,
commercialized, provided or marketed shall mean any potential drug candidate or drug product in which the Company is actively seeking to acquire an interest, directly or indirectly through an equity investment or otherwise, under the terms of a
signed letter of intent or term sheet. 
 (b) being employed by or providing services to any company or business,
even one that competes with Company, as long as such employment or services are limited to pharmacovigilance and/or medical governance and do not involve, in whole or in part, responsibility or participation in business strategy. 
 (c) passively owning two percent (2%) or less of the outstanding equity interests of any privately- or publicly-held
entity. 
 1.2 Non-Solicitation of Employees. During employment with the Company and for a period of [*]
after termination of employment with the Company (the “Non-Solicit Restricted Period”), Employee also will not, directly or indirectly, in any manner, (a) solicit, hire, or offer to hire any employee or contractor of the Company while
that person is employed or engaged by the Company and for three (3) months after the termination of that person’s employment or engagement with the Company, or (b) otherwise encourage or induce any such employee or contractor to
discontinue his or her relationship with the Company. 
 1.3 Nondisparagement. During and at all times
after the Employment Period, Employee and Company agree not to make disparaging statements, remarks or rumors about each other to any third party. For purposes of this Section 1.3, Company shall also include the Company’s parent company,
officers, directors, shareholders, employees, contractors, and/or other representatives or the Company’s Business. Provided, however, that nothing in this Agreement is intended to prohibit Employee or Company from responding in a
truthful and appropriate manner in any legal process or to give truthful and appropriate testimony in a legal proceeding. 
 [*] Confidential
treatment requested; certain information omitted and filed separately with the SEC. 
  

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 2. Consideration. The Company and Employee acknowledge that Employee has received
good and valuable consideration for Employee’s commitment to be bound by the restrictions set forth in this Agreement, which consideration includes, but is not limited to Employee’s initial employment with the Company and all of the
compensation and other benefits therewith. 
 3. Territory. The restrictions contained in Section 1.1 of this
Agreement apply to the following geographic regions: (a) worldwide, in all areas of the world in which the Company conducts or engages in the Business; (b) or, if the foregoing territory is deemed too broad, then all areas of the Americas,
Europe and Asia in which the Company conducts or engages in the Business; (c) or, if the foregoing territory is deemed too broad, then all areas of the Americas and Europe in which the Company conducts or engages in the Business; (d) or,
if the foregoing territory is deemed too broad, then all areas in the Americas in which the Company conducts or engages in the Business; (e) or, if the foregoing territory is deemed too broad, then all areas in North America in which the
Company conducts or engages in the Business; (f) or, if the foregoing territory is deemed to broad, then all areas in the United States in which the Company conducts or engages in the Business; (g) or, if the foregoing territory is deemed
to broad, then all areas in each state of the United States in which the Company conducts or engages in the Business; (h) or, if the foregoing territory is deemed to broad, then each county, parish or other similar locality of each state in the
United States in which the Company conducts or engages in the Business (herein, the “Territory”). Employee acknowledges that, because the Company engages in the Business worldwide and because Employee could compete with the Company from
anywhere in the world, the Territory must be so broadly defined. 
 4. Remedies; Extension of Restricted Periods.
Employee acknowledges and agrees that the covenants set forth in this Agreement are reasonable and necessary for the protection of the Company’s legitimate business interests, that irreparable injury will result to the Company if Employee
breaches any of the terms of this Agreement and that, in the event Employee breaches or threatens to breach any provision of this Agreement, the Company will have no adequate remedy at law. Employee accordingly agrees that in the event Employee
breaches or threatens to breach any of the covenants set forth herein, the Company shall be entitled to immediate, temporary and permanent injunctive or other equitable relief without bond and without the necessity of showing actual money damages,
subject to a hearing as soon as possible. Employee further agrees that the Company shall also be entitled to pursue, separately or concurrently, any other remedies available for such breach by Employee, including the recovery of any damages it is
able to prove. Employee further agrees that the Non-Compete Restricted Period and the Non-Solicit Restricted Period will each be extended for a period of time equal to any period during which Employee is in breach of Section 1.1 or
Section 1.2 hereof, as the case may be, and/or any period of time during which Employee and the Company are engaged in litigation arising from or related to Sections 1.1 or 1.2 hereof, as the case may be. 
 5. Enforcement. Employee agrees that, if a court of competent jurisdiction determines, contrary to the Agreement of the parties, that
any portion of this Agreement is unreasonable, invalid, overbroad or unenforceable, the remainder of the Agreement shall be given full effect without regard to the invalid provisions and the Company may enforce the covenant as to any lesser portion
of the activity, Non-Compete Restricted Period, Non-Solicit Restricted Period and/or Territory that is deemed by the court to be reasonable and enforceable

  

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under applicable law. In this regard, the covenants shall be divisible as to activity, Non-Compete Restricted Period, Non-Solicit Restricted Period and/or Territory, with each month deemed to be
a separate period of time, and each state and country, or part thereof included in the Territory, deemed to be a separate geographic area. Employee further agrees that the Company may, at its option, seek to enforce the covenant as to any lesser
activity, Non-Compete Restricted Period, Non-Solicit Restricted Period and/or Territory that the Company deems appropriate. 
 6. Effect of Termination. Employee agrees that the terms of this Agreement shall be enforceable against the Employee regardless of who terminates the employment relationship and regardless of the basis of Employee’s termination,
whether voluntary or involuntary and with or without cause. Employee further agrees that the existence of a claim by Employee against the Company, whether predicated on Employee’s termination, this Agreement or otherwise, shall not constitute a
defense to enforcement of the restrictions contained herein. Notwithstanding the foregoing, in the event the Company terminates Employee’s employment due to a reduction in force or layoff in connection with the discontinuance or cessation of a
business line, unit, function or department, the Company shall not enforce Section 1.1 of this Agreement. 
 7.
Notification. Employee authorizes the Company to notify others, including but not limited to any future employer of Employee, about the existence and terms of this Agreement and Employee’s obligations hereunder. 
 8. Jurisdiction and Venue. The parties agree that the federal or state courts sitting in Wake County, North Carolina, shall be the
exclusive jurisdiction to enforce the covenants set forth in this Agreement and to resolve any disputes or controversies arising out of or related to this Agreement. Employee consents to personal jurisdiction and venue in either of said courts, and
waives any claims or defenses based on improper venue or jurisdiction. 
 9. Governing Law. This Agreement shall be
construed and enforced in accordance with the laws of the State of North Carolina. 
 10. Severability. The provisions of
this Agreement as well as each paragraph and subparagraph hereof shall be deemed severable, and if any provisions, paragraphs or subparagraphs hereof are held to be invalid or unenforceable by a court of competent jurisdiction, the remaining
provisions, paragraphs and/or subparagraphs shall continue to be valid and enforceable. 
 11. Modification. This
Agreement cannot be altered, amended, or modified in any respect, except by a writing that specifically refers to this Agreement and the amendment(s) thereto, duly executed by the parties. 
 12. Waiver. The Company’s waiver of any violation of this Agreement or failure to enforce any provision of this Agreement shall
not constitute a waiver of the Company’s rights with respect to other or future violations of this Agreement. Any waiver must be in a writing signed by the Company and specifically refer to a waiver of provision(s) of this Agreement.

 13. Binding Effect. This Agreement shall be binding upon and inure to the benefit of the parties, their heirs,
successors and assigns. 
  

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 14. Entire Agreement. This Agreement contains the entire agreement of the parties
with respect to the matters set forth herein and supercedes all previous negotiations and discussions, agreements and understandings regarding such matters, with the exception of Employee’s Proprietary Information and Inventions Agreement, any
employment agreement to which Employee and the Company are parties, and the Severance Agreement. In the event of any conflict between this Agreement and any other the Company agreements, the terms of the agreement which are most restrictive shall
control. It is understood that this Agreement does not constitute an express or implied employment contract for any definite period of time and that, absent a written agreement between the Company and Employee, Employee’s employment with the
Company is “at will” meaning that either the Company or Employee can end the employment relationship at any time, with or without cause. 
 15. Execution in Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be deemed an original and all of which taken together shall constitute one and the
same instrument. 
 IN WITNESS WHEREOF, the parties have executed this Non-Competition and Non-Solicitation Agreement, effective
as of the last date set forth below. 
  

			
	PPD THERAPEUTICS, INC.:
		
	By:	 	 
	Name:	 	 
	Title:	 	 
	Date:	 	 
	
	EMPLOYEE:
	
	 
	Name: June S. Almenoff, MD, PhD
	Date:	 	 


  

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