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                            Funding & Awards
 Resolution of DNA Mixtures and Analysis of Degraded DNA Using the 454 DNA Sequencing Technology
Award Information
Awardee
              Children's Hospital & Research Center at Oakland
Award #
              2010-DN-BX-K141
Funding Category
              Competitive
Location
                    Oakland, CA
Awardee County
              Alameda
Congressional District
              13
Status
              Closed
Funding First Awarded
              2010
Total funding (to date)
              $699,230
Original Solicitation
              NIJ FY 10 Forensic DNA Research and Development
Description of original award (Fiscal Year 2010, $699,230)
The researchers propose to utilize the next-generation sequencing platform, 454 Roche DNA sequencing technology to establish a method to analyze mixed, limited, and/or degraded DNA samples using mtDNA and miniplex STR markers simultaneously. This project will result in two deliverables: (1) a validated "front-end" system targeting both nuclear STR and mtDNA markers for use with the 454 sequencing technology for application to forensically relevant samples (i.e. degraded and mixed); and (2) Software for the interpretation of data generated by the system.
ca/ncf



  
Grant-Funded Publications
        
                      NIJ and CHORI: Collaboration With SoftGenetics and California Department of Justice - Customizing NextGENe Software for Forensic Applications
                  NIJ and DNA: Polymerase Technologies Addressing a Key Challenge for PCR-Based Forensic Tests
                  Analysis of Mixtures Using Next Generation Sequencing of Mitochondrial DNA Hypervariable Regions
                  Resolution of DNA Mixtures and Analysis of Degraded DNA Using the 454 DNA Sequencing Technology

  
Date Created: August 31, 2010
    
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                      Comparison of Examiner Conclusions with Score-based Likelihood Ratios for Cartridge Case Evidence
                  Evaluation of the Luxon Ion Source for Rapid Screening in Forensic Laboratories
                  The Low-Down on Methamphetamine Isomers: Prevalence and Pharmacology in Humans
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