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MEMORANDUM 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, O.C. 20460 

Date: March 17, 2015 

OFFICE OF 

CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

Subject: Sethoxydim. Tolerance Revision made for the Section 3 Registration of the Herbicide 

Sethoxydim on Grass Grown for Seed; Request for an Amended Use on Blueberry; and 

Proposed Crop Group Conversions. Update to Summary of Analytical Chemistry and 

Residue Data. 

PC Code: 121001 DP Barcode: 0425783 

Decision No.: 487076 Registration No.: 7969-56 & 7969-58 

Petition No.: 4£8239 Regulatory Action: Section 3 Registration 

Risk Assessment Type: NA Case No.: 2600 

TXRNo.: NA CAS No.: 74051-80-2 

MRID Nos.: 49257702 40 CFR: §180.41 2 

FROM: 

THROUGH: 

TO: 

Peter Savoia, ChemisQ - t ·c-,( __ . .,,.L -z.,,-Y-1:.tl-___/ 

Risk Assessment Branch (RAB) V 

Health Effects Division (7509P) 

Health 

Michael 

RAB v 

Effect

/VII 

S. Metzger

s Division 

, Branch 

(7509 

C~i) ~ ~ KI f'b ~ 

Sidney Jackson/Barbara Madden, RM 05 

Minor Use and Emergency Response Branch 

Registration Division (7505P) 

And 

Ronnie J. Bever, Risk Assessor 

Risk Assessment Branch (RAB) VII 

Health Effects Division (7509P) 

A residue chemistry summary memo for the new use request of sethoxydim in/on a variety of crops 

was recently completed (D422744, P. Savoia, 12/ 18/2014). In the process of preparing the risk 

assessment for this action, the need for an update to the residue chemistry summary memo was 

identified. Accordingly, the following sections replaces the corresponding sections of the December 

18, 2014 memorandum. 

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Sethoxydim Summary of Analytical Chemistry and Residue Data DP No. D425783 

2.0 Regulatory Recommendations 

Pending submission of a revised Section F and a revised Section B to reflect the request tolerance 

revision, there are no residue chemistry considerations that would preclude retaining the established 

strawberry tolerance in lieu of conversion to fruit, low growing berry, subgroup I 3-07G: 

Strawberry .......................................................................... 10 ppm 

For the requested rapeseed subgroup 20A and sunflower subgroup 20B crop group conversions, each 

raw agricultural commodity (RAC) could be potentially processed into meal. Following the 

established meal tolerance of the representative crop, canola meal at 40 ppm for subgroup 20A and 

sunflower meal at 20 ppm for subgroup 208, tolerances for the residues of sethoxydim are also 

required for translation to the following commodities: 

Calendula, meal .................................................................. 20 ppm 

Castor oil plant, meal ......................................................... 20 ppm 

Chinese tallowtree, meal .................................................... 20 ppm 

Cuphea, meal. .................................................................... .40 ppm 

Echium, meal ..................................................................... 40 ppm 

Euphoriba, meal ................................................................. 20 ppm 

Evening primrose, meal ..................................................... 20 ppm 

Flax, meal ........................................................................... 40 ppm 

Hare's ear mustard, meal ........................... : ...................... .40 ppm 

Jojoba, meal ....................................................................... 20 ppm 

Lesquerella, meal ............................................................... 40 ppm 

Lunaria, meal ..................................................................... 40 ppm 

Meadowfoam, meal. ........................................................... 40 ppm 

Milkweed, meal ................................................................. .40 ppm 

Mustard, meal .................................................................... 40 ppm 

Niger seed, meal ................................................................. 20 ppm 

Oil radish, meal.. ............................................................... .40 ppm 

Poppy seed, meal .............................................................. .40 ppm 

Rose hip, meal .................................................................... 20 ppm 

Sesame, meal. ..................................................................... 40 ppm 

Stokes aster, meal. .............................................................. 20 ppm 

Sweet rocket cul ti vars, meal ............................................. .40 ppm 

Tallowwood ....................................................................... 20 ppm 

Tea oil plant, meal.. ............................................................ 20 ppm 

Vernonia, meal ................................................................... 20 ppm 

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Sethoxydim Summary of Analytical Chemistry and Residue Data DP No. 0 425783 

2.2.2 Recommended Tolerances 

The tolerance expressions specified for sethoxydim have been reviewed and should be updated as 

follows based on HED's Interim Guidance on Tolerance Expressions (S. Knizner, 05/27/2009). 

(a) General. Tolerances are established for the herbicide sethoxydim, including its metabolites 

and degradates, in or on the commodities in the table below. Compliance with the tolerance 

levels specified below is to be determined by measuring only the sum of the herbicide 2-[1-

( ethoxyimino )butyl]-5-[2-( ethylthio )propyl]-3-hydroxy-2-cyclohexen-1-one (CAS Reg. No. 

74051-80-2) and its metabolites containing the 2-cyclohexen-1 -one moiety, calculated as the 

stoichiometric equivalent of sethoxydim, in or on the commodity. 

(c) Tolerances with regional registration. Tolerances with regional registration are 

established, as defined in § 180. l (l), for the herbicide sethoxydim, including its metabolites and 

degradates, in or on the commodities in the table below. Compliance with the tolerance levels 

specified below is to be determined by measuring only the sum of the herbicide 2-[ 1-

( ethoxyimino )butyl]-5-[2-( ethylthio )propyl]-3-hydroxy-2-cyclohexen-l-one (CAS Reg. No. 

74051-80-2) and its metabolites containing the 2-cyclohexen-1-one moiety, calculated as the 

stoichiometric equivalent of sethoxydim, in or on the commodity. 

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