exv4w16






Exhibit 4.16




     SIXTH SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated as of January 29,
2010, among RMD NETWORKS, INC. (the “New Guarantor”), a Subsidiary of Inverness Medical
Innovations, Inc. (or its successor) (the “Issuer”), INVERNESS MEDICAL INNOVATIONS, INC., a
Delaware corporation, each of the Guarantors (the “Existing Guarantors”) under the Indenture
referred to below, and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as Trustee under the
Indenture referred to below (the “Trustee”).



WITNESSETH:




     WHEREAS the Issuer has heretofore executed and delivered to the Trustee an Indenture dated as
of August 11, 2009, as amended, supplemented and modified by a First Supplemental Indenture dated
as of August 11, 2009, a Second Supplemental Indenture dated as of September 22, 2009, and a Fourth
Supplemental Indenture dated as of November 25, 2009 (as so amended, supplemented or modified, and
as further amended, supplemented or modified to date, the “Indenture”), by and among the Issuer,
the Existing Guarantors and the Trustee, providing for the issuance of 7.875% Senior Notes due 2016
(the “Notes”);



     WHEREAS Section 4.13 of the Indenture provides that under certain circumstances the Issuer is
required to cause the New Guarantor to execute and deliver to the Trustee a supplemental indenture
pursuant to which the New Guarantor shall unconditionally and irrevocably guarantee all of the
Issuer’s obligations under the Notes pursuant to a guarantee on the terms and conditions set forth
herein; and



     WHEREAS pursuant to Section 9.01 of the Indenture, the Trustee, the Issuer and the Existing
Guarantors are authorized to execute and deliver this Supplemental Indenture;



     NOW THEREFORE, in consideration of the foregoing and for other good and valuable
consideration, the receipt of which is hereby acknowledged, the New Guarantor, the Trustee, the
Issuer and the Existing Guarantors mutually covenant and agree for the equal and ratable benefit of
the Holders as follows:



     SECTION 1. Definitions. For all purposes of this Supplemental Indenture, except as
otherwise herein expressly provided or unless the context otherwise requires: (i) the terms and
expressions used herein shall have the same meanings as corresponding terms and expressions used in
the Indenture; and (ii) the words “herein,” “hereof” and “hereby” and other words of similar import
used in this Supplemental Indenture refer to this Supplemental Indenture as a whole and not to any
particular section hereof.



     SECTION 2. Agreement to Guarantee. The New Guarantor hereby unconditionally and
irrevocably agrees, jointly and severally with all other Guarantors, to guarantee the Issuer’s
obligations under the Notes and the Indenture on the terms and subject to the conditions set forth
in Article Ten of the Indenture and to be bound by all other applicable provisions of the
Indenture.



     SECTION 3. Ratification of Indenture; Supplemental Indenture Part of Indenture.
Except as expressly amended hereby, the Indenture is in all respects ratified and confirmed and all
the terms, conditions and provisions thereof shall remain in full force and effect. This



 









 




Supplemental Indenture shall form a part of the Indenture for all purposes, and every Holder
heretofore or hereafter authenticated and delivered shall be bound hereby.




     SECTION 4. Governing Law. This Supplemental Indenture shall be governed by, and
construed in accordance with, the laws of the State of New York, but without giving effect to
applicable principles of conflicts of laws to the extent that the application of the laws of
another jurisdiction would be required thereby.



     SECTION 5. Trustee Makes No Representation. The Trustee makes no representation as to
the validity or sufficiency of this Supplemental Indenture or for the recitals contained herein.



     SECTION 6. Counterparts. The parties may sign any number of copies of this
Supplemental Indenture. Each signed copy shall be an original, but all of them together represent
the same agreement.



     SECTION 7. Effect of Headings. The Section headings herein are for convenience only
and shall not effect the construction thereof.



[Signature Page Follows]




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     IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed as of the date first above written.



	 	 	 	 	 
	 	NEW GUARANTOR:



RMD NETWORKS, INC.,

   as a New Guarantor

 	 
	 	By:  	/s/ David A. Teitel
 	 
	 	 	Name:  	David A. Teitel 	 
	 	 	Title:  	Vice President, Finance and Treasurer 	 



	 	 	 	 	 
	 	ISSUER:



INVERNESS MEDICAL INNOVATIONS, INC.

 	 
	 	By:  	/s/ David A. Teitel
 	 
	 	 	Name:  	David A. Teitel 	 
	 	 	Title:  	Chief Financial Officer and Treasurer 	 
	 



Signature Page to Sixth Supplemental Indenture (7.875% Notes — Public)





 









 





	 	 
	 

	EXISTING GUARANTORS:
	 
	 
	 

	ALERE HEALTH, LLC
	 

	ALERE HEALTHCARE OF ILLINOIS, INC.
	 

	ALERE HEALTH IMPROVEMENT COMPANY
	 

	ALERE HEALTH SYSTEMS, INC.
	 

	ALERE MEDICAL, INC.
	 

	ALERE WELLOLOGY, INC.
	 

	ALERE WOMEN’S AND CHILDREN’S HEALTH, LLC
	 

	AMEDITECH INC.
	 

	APPLIED BIOTECH, INC.
	 

	BINAX, INC.
	 

	BIOSITE INCORPORATED
	 

	CHOLESTECH CORPORATION
	 

	FIRST CHECK DIAGNOSTICS CORP.
	 

	FIRST CHECK ECOM, INC.
	 

	FREE & CLEAR, INC.
	 

	GENECARE MEDICAL GENETICS CENTER, INC.
	 

	HEMOSENSE, INC.
	 

	IM US HOLDINGS, LLC






	 	 	 	 	 
	 	By:  	                      /s/ David A. Teitel
 	 
	 	 	Name:  	David A. Teitel 	 
	 	 	Title (respectively): Vice President and
     Treasurer; Vice President,
Finance;
     Vice President, Finance; Vice
     President and Treasurer; Vice

     President and Treasurer; Vice
      President, Finance; Vice President,

     Finance; General Manager; Vice
     President; Vice President, Finance;
 
     Vice President, Finance; Vice
     President, Finance and Chief

     Financial Officer; Vice President,

     Finance; Vice President; Vice
     President, Finance and
Treasurer;
     Vice President and Treasurer;
     Treasurer; President 	 
	 



Signature Page to Sixth Supplemental Indenture (7.875% Notes — Public)





 









 





	 	 
	 

	As Guarantors (continued):
	 
	 
	 

	INNOVACON, INC.
	 

	INNOVATIVE MOBILITY, LLC
	 

	INSTANT TECHNOLOGIES, INC.
	 

	INVERNESS MEDICAL, LLC
	 

	INVERNESS MEDICAL — BIOSTAR INC.
	 

	INVERNESS MEDICAL INNOVATIONS NORTH AMERICA, INC.
	 

	INVERNESS MEDICAL INTERNATIONAL HOLDING CORP.
	 

	ISCHEMIA TECHNOLOGIES, INC.
	 

	IVC INDUSTRIES, INC.
	 

	MATRITECH, INC.
	 

	OSTEX INTERNATIONAL, INC.
	 

	QUALITY ASSURED SERVICES, INC.
	 

	REDWOOD TOXICOLOGY LABORATORY, INC.
	 

	RTL HOLDINGS, INC.
	 

	SELFCARE TECHNOLOGY, INC.
	 

	TAPESTRY MEDICAL, INC.
	 

	WAMPOLE LABORATORIES, LLC
	 

	ZYCARE, INC.






	 	 	 	 	 
	 	By:  	                     /s/ David A. Teitel
 	 
	 	 	Name:  	David A. Teitel 	 
	 	 	Title (respectively):  Vice President, Finance;
     Chief Financial Officer; Vice 
     President, Finance; Vice President, 
     Finance; Vice President, Finance; 
     Vice President, Finance; President; 
     Vice President, Finance; Vice 
     President; Vice President, Finance; 

     Vice President, Finance; Chief
      Financial Officer; Vice President,
      Finance; Vice President, Finance; 
     Vice President, Finance; Vice 
     President, Finance; Vice President;

     Chief Financial Officer and Treasurer 	 
	 



Signature Page to Sixth Supplemental Indenture (7.875% Notes — Public)





 









 





	 	 	 	 	 
	 	EXISTING GUARANTORS (continued):



MATRIA OF NEW YORK, INC.

 	 
	 	By:  	/s/ Tom Underwood
 	 
	 	 	Name:  	Tom Underwood 	 
	 	 	Title:  	President 	 
	 



Signature Page to Sixth Supplemental Indenture (7.875% Notes — Public)





 









 





	 	 	 	 	 
	 	TRUSTEE:



THE BANK OF NEW YORK MELLON TRUST 
   COMPANY, N.A.,

   as Trustee

 	 
	 	By:  	/s/ Peter M. Murphy
 	 
	 	 	Name:  	Peter M. Murphy 	 
	 	 	Its: Vice President 	 
	 



Signature Page to Sixth Supplemental Indenture (7.875% Notes — Public)