Form of Common Stock Certificate



 Exhibit 4.1 
 

 
  
 Exhibit 4.1 
 Trius 
 Therapeutics 
 COMMON STOCK 
 NUMBER 
 TTI 
 INCORPORATED UNDER THE LAWS OF 
 THE STATE OF DELAWARE 
 THIS CERTIFICATE IS TRANSFERABLE 
 IN JERSEY CITY, NJ, NEW YORK, NY 
 AND PITTSBURGH,
PA 
 TRIUS THERAPEUTICS, INC. 
 COMMON STOCK 
 SHARES 
 SEE REVERSE FOR CERTAIN DEFINITIONS

 CUSIP 89685K 10 0 
 THIS CERTIFIES THAT 
 is the record holder of

 FULLY PAID AND NONASSESSABLE SHARES OF COMMON STOCK, PAR VALUE OF $.0001 PER SHARE, OF 
 TRIUS THERAPEUTICS, INC. 
 transferable on the books of the Corporation by the holder hereof in person or by duly authorized attorney upon surrender of this Certificate properly endorsed.This Certificate is not
valid unless countersigned and registered by the Transfer Agent and Registrar. 
 WITNESS the facsimile seal of
the Corporation and the facsimile signatures of its duly authorized officers. 
 Dated: 
 Chief Financial Officer and Secretary 
 TRIUS THERAPEUTICS, INC. 
 CORPORATE 
 SEAL 2007 
 DELAWARE 
 President and Chief Executive Officer 
 COUNTERSIGNED AND REGISTERED: 
 MELLON INVESTOR SERVICES LLC 
 TRANSFER AGENT AND REGISTRAR 
 BY 
 AUTHORIZED SIGNATURE 
 AMERICAN BANK NOTE COMPANY 







 

 
  
 The
Corporation shall furnish without charge to each stockholder who so requests a statement of the powers, designations, preferences and relative, participating, optional or other special rights of each class of stock of the Corporation or series
thereof and the qualifications, limitations or restrictions of such preferences and/or rights. Such requests shall be made to the Corporation’s Secretary at the principal office of the Corporation. 
 The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they
were written out in full according to applicable laws or regulations: 
 TEN COM — as tenants in common

 TEN ENT — as tenants by the entireties 
 JT TEN — as joint tenants with right of survivorship and not as tenants in common 
 UNIF GIFT MIN ACT— Custodian (Cust) (Minor)under Uniform Gifts to Minors Act (State) 
 UNIF TRF MIN ACT— Custodian (until age) 
 (Cust) 
 under Uniform Transfers 
 (Minor) to Minors Act 
 (State) 
 Additional abbreviations
may also be used though not in the above list. 
 FOR VALUE RECEIVED, hereby sell, assign and transfer unto

 PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE 
 (PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE) 
 Shares of the common stock represented by the within Certificate, and do hereby irrevocably constitute and appoint

 Attorney to transfer the said stock on the books of the within named Corporation with full power of
substitution in the premises. 
 Dated 
 X 
 X 
 NOTICE: 
 THE SIGNATURE TO THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME AS WRITTEN UPON THE FACE OF THE CERTIFICATE IN EVERY PARTICULAR, WITHOUT ALTERATION OR ENLARGEMENT OR ANY CHANGE WHATEVER.

 Signature(s) Guaranteed 
 By 
 THE SIGNATURE(S) MUST BE GUARANTEED BY AN
ELIGIBLE GUARANTOR INSTITUTION (BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM), PURSUANT TO S.E.C. RULE 17Ad-15.