aphthalene acet ates D ietary Exposure and Ri sk Assessme nt D P # : 426996 

### UNITED STATES ENVIRONMENTAL PROT ECT ION AGENCY
WA S HI NGTON, D .C. 20460

OFFI C E OF C H EM I C AL SA FETY AND POLLUTIO N PREVE N TION



### MEMORANDUM
Date: Nov emb e r 

### 18 , 20 1 5


### SUB J ECT: Naphthalene Acetates- C hroni c Di e tary and Drinkin g Water Expos ure and Ri s k Assess m e nt for Sect io n 

### 3 New Use o f Napht hal e ne Acetic Ac id -es te r o n P omeg r anate.

P C Co d e: 05600 I, 056002. 056003 , 056004

. 056007 , 056008 Dec is ion No.: 495111 P eti ti o n No.: 4E83 I0 Ri s k A ssess ment T y pe: Dietary TXR No.: NA MRID No

. : NA 

### FROM:

THROUGH: Elissa Reaves, Ph .D

. , Chief Ri s k Assess ment Bra nch 4 H ea lth Effec t s Division (7509 P) DP Barcode: 0 426996
Re g is tration No.: 87320-E Regu lat o r y Action: Section 3 C a se No.: 0379 C AS No.: 2 122 -70- 5 40 CFR: § 180.155 (a) & (b)

# ~~

and 1 1 I /i 

# y I 

# yrt

. William Cutc hin ,

## Che**mi st** **f;-~ .:..** **I"'** l

- G · fv:-. Kristin Rury , Biologist 

# g/:/ /

.**~** Dietary Expos ure Sc ience AdvisbrY

### ~I {12)ESAC) H ED (7509 P )


### TO: S id ney J ac kson/Barbara Madden Minor Use & Emer ge n cy Res pon se Branch Reg is tr ati o n Division (75 0 5P)
This document provides c h ronic dietary (foo d and drinking water) ri s k a n a lyses of ex posure s resulting from use of naphtha lene acetates as plant act ivators fo r the new use o n pomegranate.

P age 

### I of 

### IO**~hthalene** acetate s Dietary Exposure and Risk Assessment DP # : 426996 

### Executi ve S umm ary
Chronic dietary risk assessment was conducted for naphthalene acetates usin g the Dietar y Ex posure Evaluation Model software with the Food Commodity Intake Database (DEEMFC ID) , Vers i on 3. 16, wh ich incorporates 2003-2008 food consumption data from the U.S. Department of Ag riculture ' s (US DA 's) Nat ional H ea lth and N utrition Examination Survey , What We Eat in America, (NHANES / WW EIA). The analysis was performed to support a Section 3 reque s t for use of naphthalen e acetates (NAA) on pomegranate.
This memorandum was review e d by two peer rev iewers of the DESAC, per DESAC SOP 20 12 .1.
Acute Dietary Exposure Results and Characterization
There were no toxicological effects attributab l e to a s in gle exposme (dose) ofNAA observed in oral toxicity studies including the developmental toxicity studies in rats or rabbit s. Therefore , a dose and an endpoint for acute dietary exposure were not identified for NAA and a quantitative acute dietary exposure assessment was not conducted.
Chronic Dietary Exposure Results and Characterization
A co nservative chronic dietary and drinking water exposure analysis was performed for the general U.S. popu lation and va rious popu lat ion subgroups. Tolerance level residues and 

### I 00 p e rcent crop treated assumptions were used. DEEM defau l t proces s ing factors were used to mo dify th e tol erance values. The chronic ana lysis incorporated the I 0 year average surface drinking water es timate from application of naphthal e ne acetates to o lives. The chronic dietary exposure es timate for the high es t exposed population s ubgroup , children 1- 2 years of age , is 0.036203 mg/k g/day or 1 5% of the cPA D. T h e chron ic dietary exposure estimate for the ge neral populati on is 0.013977 mg/ kg/da y or 5.6% of the cPAD.
Cancer Dietary Exposure Resu l ts and C haracte rization Naphthalene acetates is cons idered " not like ly to be a human carcinogen; " therefore , quantification of human cancer risk i s not required.
I. 

### Introdu c ti o n
Di e tary ri s k assessment incorporates both exposure and toxicity of a g iven pesticide

. For acute and chronic assessments , the ri s k is expressed as a percentage of a maximum acceptable dose ( i. e., the dose which HED has co ncluded will result in no unreasonable adverse health effects). Th is dose is refe rred to as the PAD. The PAD is eq ui va lent to point of departure (PO D , NOAEL , lowe st observed adverse effect le ve l (LOAEL ), e.g.) di vi d ed by the required uncertainty or safety factors

.
Page 2of 10Naphtha lene acetates Di e ta ry Exposure and Ri sk Assessment DP # : 426996



### For acute and non-cancer c hroni c expos ures, HED is co ncern ed w hen estimated di eta ry ri sk exceeds 100% of the PAD. References which discuss the acu t e and chronic ri s k assess men ts in more detail are avai lable on the EPA/ pe st ici d es web site: ' ·Availab le Information on Assessing Exposu re from P est ic ides , A Use r 's Guide ," 21

- JUN -2000 , web link: http: //www.epa.gov/fedrgstr /EPA -PEST/ 2000/J uly/Day-1 2/ 606 1 .p df; o r see SO P 99.6 (20- AUG-1999).
The mo s t recent dietary ri s k assessment for NAA was conducted b y T. Morton (DP 404399 , 3 /2 1 / 13).
II . Residue Information


### 1

-Nap h tha l e neacetic acid (NAA) , its salts , es t e r, and acetamide are plant growth regulators w hich are collectively referred to as naphthalene acetates. T hey are currently regis tered fo r use on various orchard and fruit crops includin g app le, cherry, olive. orange, pear , tangelo, and tangerine. Nap hthalene acetates are u sed to preve nt preh arvest d rop of fruits , thin fruit trees , and delay flower in duction. T ole rances for res idu es of naphthal e ne acetates in/on food and feed co mmoditi es are curre ntl y es tab li shed und e r 40 CFR 

### § 180

. 1 55, and are ex presse d in terms of 1- naphthaleneacetic acid , [e th y l ester of 1- naphthaleneacetic ac id , and naphthal e neacetamide].
The petitioner has r equested Section 3 fo r use of naphthalene acetates on pomegranate. Residues used in the c hr o nic dietary a na lyses are provided in Tabl e 1

.
Tab l e I. To lera n ce Va lu es Use d in Na phth a le n e Acetate s Di eta r y Expos ure A nal yses RA C To lera nc e ( ppm) P

omc Fruit Subgroup 11-1 0 0. 15 C herry. sweet 0. 1 Olive 0.7 Oranges 0.1 Pineapp l e 0.05 Tangerine 0.1 Avocado 0.05 Potato Seed Piece 0.0 1 Man go 0.05 Marne y Sapote 0.05 Rambutan 2 .0 Propose d Ne w Use R eco mm ended To lerance Po me g ranate 0.05


### Th e US D A Pesticide D ata Program (PDP) m o nitore d pest ic id e res idu es i n catfi s h in 2 008 , 2009 , an d 20 l 0. PDP did not ana lyze catfish sa mpl es fo r NAA res idu es. As a result , r es idue s in fi s h were not included in the assessment. Page 3of 10Naphthalene acetates Di etary Exposure and Risk A ssess ment DP # : 426996



### III

. P e rcent C rop Treated Inform a tion
The chronic dietary expos ure a ssess ment assumed that 100% of the proposed and registered crops were treated with naphthalene acetate s ( 100 % CT).


### IV. 

### Drinkin g Water Data
Tier I Esti mated Drinking Water Concentrations (EDWCs) in surface and groundwater for 1- naphthaleneacetic ac id (NAA) and its assoc iated sa lt s 1-naphthaleneacetic acid , sod ium salt (NAA sodium sal t) and 1-naphthaleneacetic acid, potassium salt (NAA pota ssi um sa lt) , ethyl ester (NAA e thyl ester) and acetamide (NAA acetamide) 1 were provide for use in the dietary ex posure assessment. The EDWCs were ca lculated using the Tier 1 surface water aquatic mod e l FIRST and the Tier l/Il groundwater model PRZM-GW (in Tier I mode). The Environmental Fate and Effects D i vis io n (EFED) h as reviewed a proposed Interregional Research 4 (IR-4) and registrant petition to regi s ter th e use of NAA ethyl es ter for the use on pomegranat e for
co ntrollin g basal trunk sprouts and root suckers 

### (J. Me lendez, 04 234 1 0 , 5/ 4/ 15). The maximum si ngle application rate is 3.6 lb a.e ./ A 2

, with two applications allowed at 60 day intervals , for the product Tre-Hold ® Sprout Inhibitor A- 1 12 ( E PA Reg. No. 5481-429, co ntaining I lb a.e ./gallon). Only ground applications are allowed on pomegranate , diluted in a large volume of water , applied to th e lower tree trunks and immediate su rroundin g area. Previously , the maximum rate allowed was for the use on olives (single application at 0.33 lb a.e ./ A). Since thi s new u se repre se nts a higher app li cation rate than previously calcu lated, and no groundwater va lu es derived from PRZM

- GW were previously calculated, new EDW Cs are hereby calculated and provided.

Ta bl e 2. Maxi mum T ier I Estim ate d Drinking Water Co n ce ntra tion s (E DW Cs) 

### for dri nkin g wate r assess ment for a ll NA A r e late d compounds (collective ly known as n a phthalen e acetates) , b ase d on 1roun d 

### r . f N 6

. . I a pp 1 cahon o AA ethyl ester o n pom ee: r ana te s a t 3. lb a.e./A x 2 a pph catt o n s•vear DRI NK I NG WATER**MAX ~lllM**  ESTl l\I A TED DR I NK ING SOU R CE (MODEL USED) SCENA RIO (rate mo d ele d pe r crop cycle) WATER CONCENTRAT I OI" (EDWC) Cnn b) Groundwater (P RZM- WI sand/7.2 lb a.e ./ A

/yr Acute 789 GW) WI sand/7.2 lb a.e ./A/ yr Chronic 646 Surface water ( FIRST) Inde x Reservo ir /7 .2 lb a.e ./A/yr Acute 440 Ind ex Re se rvoir /7 .2 lb a.e ./ A/yr C hronic 65.1


### V

. DEEM-FCID Prog ram a nd Co n s umption Information
Na phthalene acetates chronic dietary exposure assessments were conducted using the Di e tary Exposure Eval u ation Mode l software with the Food Commodity Int ake D atabase DEEM-FCID , Version 3.16 , which incorporates consumption data from USDA ' s National Health and Nutrition

I Co lle ctively known as naphthalene acetate s
. 2 The abbreviation a.e. refer s to acid equivalents (i. e., the lb s ofNAA ethyl ester, expressed as lb s ofNAA acid). Page 4of10Naphthalene acetat es Dietary Expos ure and Risk Asses s m e nt D P # : 426996
Examination Survey , What We Eat 

### in America , (NHANES/ WWEIA). Thi s dietary survey was conducted from 2003 to 2008. The data are based on the repo rted consumptio n of more than 20 , 000 individuals over two non-consec u tive survey days. Foods "as co n su m ed " (e.g., app le p ie) are linked to EPA-defined food commod ities (e.g. app l es , pee l ed fruit

- cooked ; fres h or 

### N IS; baked; o r wheal fl ou r - cooked ; fresh or N/ S , baked) u s in g p u blicl y available rec ipe translatio n file s developed jointly by US D NARS and EPA. For chronic exposure asses s me n t , consumption data are averaged for the entire U.S. population and w ithin popu lation s ubgroup s, but fo r acute expos ure asses s ment a re reta ined as in d ividual consumption event s. Based on ana lys i s of the 2003-200 8 WWE IA consumption data , which took into account di e tary pattern s and survey responde nts , H E D concluded that it i s mos t ap propri ate to report ri s k for t he fo ll ow ing population s ubgroup s: th e ge n eral U.S. population , all infants (< I yea r old) , c hildren 1

- 2 , children 3-5, c h i ldren 6-1 2, youth 13-19 , adults 20

-49 , females 13-49 , and adu lts 50-99 years o ld.
For c hr o nic di e tary ex po su re assessment , an es timate of the residu e leve l i n each food or foodform (e.g., orange or orange juice) on th e food comm o d ity res i due li s t is mult i p li ed by t h e ave rage dai ly consumpti o n es tim ate for that food/food form. The r es u l ting res i due co n s umpt ion estimate for each food/food fo rm is summed with the r es idue con s umption estimates for all other food / food forms on the commodity re s idu e list to arrive at the total average estimated expo su re. Ex p os ure is expressed in m g/kg body weight / day and as a percent of the cPAD. This proc e dure is pe rformed for eac h populat ion s u bg roup.


### VI. Tox ico log i ca l Inform a ti o n
HED eva luated the toxico logy data base for naphthal e ne acetates and selected th e fo ll owing doses and e ndpoint s for dietary risk asses s me n ts.

Page 5 of JONaphtha lene acetates Dieta ry Expos ure and Ri s k Assessment DP #: 426996
Table 4

. 5

. 4

. 1. Summary of Toxico logical Endpoints for Naphthalene Acetates for Use i n Dietary a nd NonOcc u pational Hum a n Hea l th ru s k Assessme n t s Point o f U nc e r tainty/FQ P RID, PAD, Study and Toxic olog ical E ffect s' Ex po s ure/Sce nario LOC for Ri s k D e p a rture A Safety Facto r s Assess m e nt Acute Di etary An acute RID for the general population or any popu lation s ubgroups was not se lec ted because no (Ge neral Population) effec t attribu t able to a sing le da y o ral exposure was observed in animal s tudies.
Co-crit ica l Dog St ud ies with NAA Na sa lt: Subchronic T oxicity (MRID 4298380 I ) C hronic Toxicity (M R1D 43744201)

Chro ni c RID = Subchronic LOAEL = 150 mg/k g/ day based Subc hronic UF" = IOx 0.25 on GI tract les ions and hypocel lul arity of the Chronic Dietary NOAEL= UF11 = IOx m g/kg/day bone marrow (All Populations) 25 FQPASF= Ix S ub c hr o n ic NOAE L = 25 m g/k g/d ay mg/kg/day cPAD = 0.25 mg/k g/day C h roni c LOA EL= 75 m g/kg/ da y based on s tomach lesions in 75% of the ma les and slight sinuso id al histiocytosis in the liver of 50% of the males Chron ic NOAEL = 15 mg/kg/day
Cancer Bio assay in rats and mice not carcinogenic. Not mutagenic.



### VII. R es ults/ Di sc u ss ion
As stated above, for c hron ic assessments, HED i s concerned when d ietary ri sk exceeds I 00% of the PAD. The D EEM -F C ID analyses estimate the dietary ex p osure of the U.S. population and various populati on s ubgroups. T he results re ported in Table 4 are fo r the general U.S

. Popul atio n , a ll in fants (< I year o ld ), chi ldren 1- 2, c hildren 3

- 5, c hildren 6

- 12 , youth 1 3-19, fema l es 13-49 , adu l ts 20-49, and adult s 50-99 years.
Resu lt s of Chronic Dietar y Exposur e A na l ysis

T a bl e 4. S umm arv o f C h roni c Di ctarv Ex o os ur e a n d Ri s k for NAA P o pu l atio n S u bg r o up cPAD (m g/k g/da y) C hr o n ic Exposure ( m e/kg/ da y) %c PAD General U.S. Pooulation 0.0 13977 5.6 A ll In fants(< I year old) 0

. 036203 15 Children 1-2 year s old 0.022367 8.9 C hildren 3

- 5 yea rs old 0.018232 7.3 Children 6-12 years old 0.25 0.012575 5.0 Youth 13-19 years old 0.010202 4.1 Adu l ts 20-49 year s old 0.013738 5.5 Adults 50 -9 9 years old 0.013583 5.4 Female s 13-49 year s old 0.01370 1 5.5 Page 6of 10Naphthale ne ace tate s Di etary Ex posure and R isk Assessment DP # : 426996



### VIII . C h a racterizati o n of Inputs/Outputs
The chronic dietary analysis is conservati ve. To leranc e level r es idues used in the ana lys i s are expected to excee d the re s idu es ac tuall y co n s um e d

. In additio n , the 

### 100 % crop treated esti m ate used for a ll crops in th e as sess ment w ill co n s id e rably overestimate the actual perce n t crop treated.
IX . C o nclu s ions
Based on sc r eenin g level a na l yses of est im ated dietary ri sks fo r the gene ral U.S. p op ul atio n and variou s population subgroups , the chronic di e tary e x posure es tim ates for n a ph thal e ne acetates are sig nificantly below H E D 's level of co ncern fo r a ll s upp o rte d commoditie s. The chro n ic dietary expos ure est im a t e for the hi g hest exposed population s ubgro up , all infant s 

### < l year old , is 

### 0.036203 mg/kg/d ay or 

### 1 5% of the c PAD

. X . Li s t of Attac hm e nts 

### 1. C hronic DEEM

- FC ID Res idu e Inpu t Fil e. 2. Resu lt s of Chro n jc D EE M-FC ID Di etary Ex posure A nalys is.

Page 

### 7 o f IONaphthalene acetates Dietary Expo sure and Risk Assessment DP #: 426996 

### Attachme nt I Chronic D EEM-FC ID R esidue Input File

Filename: C:\Users\tmorton\Documents\My Files \DEEM Files\056003 NAA\4E8310 Pomegranate\056003 Chronic4E8310 Food and Water.ROS Chemical: NAA RfD(Chronic):

. 25 mg/kg bw /day NOEL(Chronic) : O mg/kg bw/day RfD(Acute): O mg/kg bw/day N OEL(Acute): o mg/kg bw/day Date created/last modified : 05-22-2015/07:08:27 Program ver. 3.16, 03-08-d



### ------------- --- -------- --- --------- --- ----- --- -------- ----- ---- ---- --------------- Crop EPA Code Grp Commodity Name Def Res (ppm)
0103296000 lC 01032 9700 0 lC 0103297001 lC 0103298000 lC 0103298001 lC 0103299000 lC 0103299001 lC 0103300000 lC 0103300001 lC 1001240000 lOA 100124 1000 lOA 1001241001 lOA 1001242000 lOA 1001369000 lOA 1001370000 lOA 1100007000 11 1100008000 11 1100008001 11 1100009000 11 1100009001 11 11000 1 0000 11 11000 1000 1 11 11000 11000 11 1100011001 11 1100129000 11 1100210000 11 1100266000 11 1100266001 11 1100267000 11 1100268000 11 1100268001 11 11003 1 0000 11 1201090000 12A 12010 9000 1 12A 1201091000 12A 1201091001 12A 8601000000 86A 8602000000 86B 9500020000 0 9500 215 000 0 9500215001 0 9500216000 0 9500217000 0 9500217001 0 9500235000 0 9500236000 0 9500279000 0 9500279001 0 9500280000 0 9500281000 0 9500281001 0 9500289000 0 9500333000 0 Potato, chips Potato, dry (granules/ flakes) Potato, dry (granul es / flakes)-b Potato, flour Potato, flour -babyfood Potato, tub er, w/peel Potato, tuber, w /p eel-babyfood Potato, tuber, w/o peel Potato, tuber, w/o peel-babyfood Orange Orange, juice Orange, juice -babyfood Orange, peel Tangerine Tangerine, juice Apple, fruit with peel Apple, peeled fruit Apple, peeled fruit -b abyfood Apple, dried Apple, dried-babyfood Apple, juice Apple, juice-babyfood App le, sauce Apple, sauce-babyfood Crabapple Loquat Pear Pear-babyfood Pear, dried Pear. juice Pear, juice-babyfood Quince Cherry Cherry-babyfood Cherry, juice Cherry, juice-babyfood Water, direct, all sources Wat er, indirec t, all sources Avocado Mango Mango-babyfood Mango, dried Mango, juice Mang o , juice-babyfood Olive Olive, oil Pineapple Pineapple-babyfood Pineapple, dried Pineapple, juice Pineapple, juice-babyfood Pomegranate Sapote, Marney 0.010000 0.010000 0.010000 0.010000 0.010000 0

. 010000 0

. 010000 0.010000 0

. 010000 0.100000 0.100000 0.100000 0.100000 0 .1 00000 0.100000 0.150000 0.150000 0.150000 0 .15 0000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.100000 0.100000 0.100000 0.100000 0.646000 0.646000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.700000 0.700000 0.050000 0.050000 0

. 050000 0.050000 0.050000 0.050000 0.050000 

### Page 8of10 Adj.Factors Ill 112
1. 000 1. 000 6 .500 1.000 6.500 1.000 1. 000 1. 000 1. 000 1. 000 1. 000 l. 000 1. 000 1. 000 1.000 1. 000 1. 000 1. 000 1. 000 1. 000 1. BOO 1. 000 l. 800 l. 000 l. 000 1. 000 1. 000 l. 000 2. 300 1. 000 1.000 1.000 1. 000 1. 000 l. 000 1. 000 8.000 l.000 8. 000 1. 000 l.300 1.000 1.300 1.000 l. 000 1. 000 1. 000 l. 000 1.000 1. 000 1. 000 1. 000 l .000 1.000 1. 000 l. 000 6.250 1.000 1.000 l. 000 l. 000 1. 000 1. 000 1. 000 l. 000 l. 000 1. 000 l. 000 1. 500 1. 000 1. 500 1. 000 1.000 l.000 l. 000 l. 000 l. 000 l. 000 l.000 l.000 1

. 000 1.000 l. 000 1. 000 1. 000 1. 000 1. 000 1. 000 l.000 l.000 1.000 1.000 1.000 1.000 l. 000 l. 000 5. 000 1. 000 l. 700 1. 000 l. 700 1. 000 1.000 1.000 l. 000 l. 000 CommentNaphtha len e ace t ate s Di e t ar

y Exposure and Ri sk Assess me nt 

### A ttachme nt 2 Results of C hronic DEEM- FC ID Dietar y Ex posure Ana lys is FOOD an d 

### Water DP # : 426996

us EPA Ver. 3.16. 03-08-d DEEM-FCID Chronic analysis for NAA NHANES 2003-2008 2-day Residue file name: C:\Users\tmorton\Documents\My Files \DE EM Files \OS6003 NAA \ 4E8310 Pom egra nate\05600 3 Chro nic4E8 310 Food and Water

. ROS Adjustment factor U2 used. Analysis Date 09-ll-2015/12:44:S7 Residue file dated: 09 -11- 2015/12:43 :13 Reference dose (RfD, Chronic) 

### = .2S mg /kg bw/day
Total exposure by popu latio n subgr oup

Total Exposure Popula tion

Subgr oup Total US Population Hispanic Non

- Hisp-White Non

- Hisp-Black Non-Hisp-Other Nursing Infants Non-Nursing Infants Femal e 13+ PREG Children 1- 6 Children 7-12 Male 13-19 Female 13-19 / NP Male 20+ Fema le 20+/NP Seniors SS+ All Infants Female 13

- so Children 1-2 Children 3-S Children 6-12 Youth 13-19 Adults 20-49 Adult s S0-99 Femal e 13- 49 mg/kg body wt / day
0. 013977 0. 013S90 0. 014296 0.011706 0. 016118 0 .013061 0.046S39 0. 013221 0.019399 0. 011907 0

. 0096Sl 0 .010741 0 .012842 0.014443 0 .013322 0 .036203 0. 013719 0 .022367 0 .018232 0 .012S75 0.010202 0 .013738 0.013S83 0.013701



### Page 9 of 10 Perc ent of Rfd S.6\ S.H S.7\ 4. 7\ 6.4\ S.2\ 18 .6\

s .3\ 7.8\ 4.8\ 3.9\ 4 .3\ S .l\ S.8\ S.3\ 14

. S\

5.5\ 8.9\ 7. 3\ 5.0\ 4 .1\ S.S\ s .4\ S.5\Naphthalen e acetates Dietary Ex p osu re and Ri sk Assessment DP # : 426996

Fo od Onl y

US EPA Ver. 3.16, 03 -0 8-d DEEM

- FCID Chronic analysis for NAA NHANES 2003-2008 2

- day Residue file name: C:\Users\tmorton\Documents\My Files\DEEM Files \05 60 03 NAA \4E8 31 0 Pomegranate \0 56003 Chronic4E8310 Food Only.ROS Adjustment factor #2 us ed. Analysis Date 09 -11 -201 5 /12 :45:24 Residue file dated: 09-11-2015/12:43 : 52 Reference dose (R fD, Chronic) = .25 mg / kg bw / day


### ========================================================= == =a== == ============== T o ta l exposure by population subgroup

Population

Subgroup
Total US Population Hispanic Non-H is p-White Non

- Hisp-Black Non

- Hisp -Ot her Nur si ng Infants Non

- Nursing Infants Female 13+ PREG Children 1-6 Children 7

- 12 Mal e 13-19 Fem al e 13-19/NP Male 20+ Fema le 20+/NP Seniors 55+ All Infants Female 13-50 Children 1 -2 Children 3-5 Children 6-12 Youth 13 -19 Adults 20

- 49 Adu lts 50

- 99 Female 13-49 Total Exposure mg/kg body wt /day 0.000450 0 .00 0 675 0 .00 0383 0 .00 0545 0 .000528 0 .0 00823 0.001548 0.000 484 0 .0 02074 0.000630 0 .00 035 2 0

. 000321 0.000240 0 .00 0 236 0.000244 0.001325 0 .00 02 57 0 .0 02854 0.001792 0 .00 071 9 0 .000 338 0.000242 0 .0 00 241 0.000255

Page 10of10 Percent of Rf d 0.2\ 0 .3\ 0.2\ 0.2\ 0.2\ o. 3\ 0.6 \ 0.2\ 0.8\ 0. 3\ 0

. 1\ 0

. 1\ 0 .1\ 0 .1\ o.n 0.5\ 0

. 1\ 1.1\ 0.7\ 0 .3\ 0.1\ 0 .1\ 0

. 1\ 0.1\