The attached documents include the following:

Doc ument Title Date

Chlorpyrifos Issue Paper: Evaluation of Biomonitoring

Data from Epidemiology Studies March 11, 2016

Chlorpyrifos: Analysis of Biomonitoring Data

Charge to the FIFRA SAP for the April 19

- 21, 2016

Meeting March 18, 2016

Multi

- Route, Lif estage, and Pregnancy PBPK/PD model

for Chlorpyrifos and Chlorpyrifos

- Oxon: Model

development and validation April 30, 2015

FIFRA Scientific Advisory Panel. 2008. December 17, 2008

FIFRA Scientific Advisory Panel. 2012. July 11, 2012

USEPA. 2015. D33125 1. Literature Review on

Neurodevelopment Effects & FQPA Safety Factor

Determination for the Organophosphate Pesticides September 15, 2015

Whyatt and Rauh (2011). Chlorpyrifos Correspondence

with Columbia Researchers: (1) Responses to Scientific

Advisory P anel (SAP) comments (Whyatt and Rauh

2010), and (2) Responses to Dow AgroSciences inquiries

(Whyatt 2010). June 30, 2011

Appendix 2 Dose Reconstruction Summary Table March 18, 2016

USEPA. 2014a. D424485. Chlorpyrifos: Revised Human

Health Risk Assessm ent for Registration Review December 29, 2014

Drew, D. 2014. D424486. Chlorpyrifos Acute and Steady

State Dietary (Food Only) Exposure Analysis to

Support Registration Review November 18, 2014

Poet. 2015. Multi

- Route, Lifestage, and Pregnancy

PBPK/PD mo del for Chlorpyrifos and

Chlorpyrifos

- Oxon: Model development and validation. April 30, 2015

USEPA. 2015. D429120. Summary Reviews from 2015

Epidemiological Literature Review for

Organophosphates. September 15, 2015

USEPA. 2014d. D417053. Chlorpyrifos: Quality

Assurance Assessment of the Chlorpyrifos

Physiologically Based

Pharmacokinetic/Pharmacodynamic Model for Human

Health Risk Assessment Applications February 19, 2014MODEL FILES

Main model files. Please note, all three of the below model files a re needed in order to

run any scenarios.

CPF Lifestage 2015_Aug_15

human_parameters_MRP

preg_female_parameters

Model Input Files. Please note, "Food, "Food1," and "Drinkingwater" are needed to

run model s for relevant scenarios.

Food (required in order to run all food scenarios)

Food1 (required in order to run the PODs, associated with table 1.2)

Drinkingwater (required in order to run drinking water scenarios)

Figure 9 Bulb Onion GAOnion Input File (expressed in daily water concentration, input

for "Drinkingwater" file above)

Figures 12

- 15 Input Orestimba Creek Site Input File (expressed in daily water

concentration, input for "Drinkingwater" file above)

CPFOS SS F13_49 Foodonly Exp Distribution In put File (expressed in daily water

concentration, input for "Food" file above)

PBPK Seed Treatment Scenarios Input File (for occupational scenario model code)

Occupational Soil Incorporation for PBPK Input File (for occupational scenario model

code)

Sen ario

- specific code

Table 2 CPF adult food 10 Model Code

Table 2 CPF adult food 30 Model Code

Table 2 CPF adult food 50 Model Code

Table 2 CPF adult food 70 Model Code

Table 2 CPF adult food 90 Model Code

Table 2 CPF adult food 95 Model Code

Table 2 CPF adult food 975 Model Code

Table 2 CPF adult food 99 Model Code

Table 2 CPF adult food 995 Model Code

Table 2 and Figure 5 CPF adult food 99 Model Code

Table 11 Applicator Seed Planting Model Code

Table 11 Applicator Seed Treatment Model Code

Tabl e 11 Applicator Spray Cole Model Code

Table 11 Mixer Dry Cole Model Code

Table 11 Mixer Liquid Cole Model Code

Table 12 Applicator Spray Corn Model CodeTable 12 Applicator Seed Planting Model Code

Figure 6 and Table 3 Broadcast HardSurface Model Code

Figure 6 and Table 3 Perimeter Carpet 8h 30day Model Code

Figure 7 and Table 3 Residential 30day Model File

Figure 8 and Table 3 Residential Firstday Model Code

Figure 9 Bulb Onion GAOnion Model Code

Figure 12 Onion Water Adult Model Code

Figure 13 Orestimba Creek Adult Model Code

Figure 14 Onion Water Infant Model Code

Figure 15 Orestimba Creek Infant Model Code

Table 1.2 Adult Food POD Code

Table 1.2 Worker POD Code

Scenario

- specific Output Files

Table 2 food_10 Output Files

Table 2 food_30 Output Files

Table 2 food_50 Output Files

Table 2 food_70 Output Files

Table 2 food_90 Output Files

Table 2 food_95 Output Files

Table 2 food_975 Output Files

Table 2 food_99 Output Files

Table 2 food_995 Output Files

Table 2 and Figure 5 food_999 Output Files

Figures 2a & 2b Mixer Liquid Cole Output File

Figure 6 and Table 3 Broadcast Hardsurface 30day Output File

Figure 6 and Table 3 Perimeter Carpet 8h 30day Output File

Figure 7 and Table 3 Residential 2h 30day Output File

Figure 7 and Table 3 Residential 8h 30day Output File

Figure 8 and Table 3 Residential Firstday 60 2h 30day Output File

Figure 8 and Table 3 Residential Firstday 60 8h 30day Output File

Figure 10 MRID 44711601 All Water Data Output File

Figure 12 Onion Adult Output File

Figure 13 Orestimba Creek Adult Output File

Figure 14 Onion Infant Output File

Figure 15 Orestimba Creek Infant Output File

Figures 16 & 17 Applicator Spray Cole Output File

Table 11 Applicator Spray Cole Output File

Table 11 Applicator Spray Corn O utput File

Table 11 Mixer Dry Cole Output FileTable 11 Mixer Liquid Cole Output File

Table 11 Mixer Liquid Corn Output File

Table 12 Applicator Seed Planting Output File

Table 12 Applicator Seed Treatment Output File

Table 1.2 Food POD Output File

Table 1.2 Worker POD Output File