Clcthodim Dietary Exposure and Risk Assessment DP Number: 431223 

PC Code: 121011 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MEMORANDUM 

DATE: 01/19116 

SUBJECT: Clethodim: Acute and Chronic Aggregate Dietary (Food and Drinking 

Water) Exposure and Risk Assessments for New Uses on Stevia; Pome 

Fruit Crop Group 1 1-1 O; Stone Fruit Crop Group 12-12; and Crop 

Group/Subgroup Expansions for Onion, Bulb Subgroup 3-07 A; Fruiting 

Vegetables Crop Group 8-1 O; Low growing Subgroup 13-07G, except 

Cranberry; Rapeseed Subgroup 20A, except Flax Seed; Sunflower 

Subgroup 208; and Cottonseed Subgroup 20C. 

PC Code: 121011 

Decision No.: 497978 

Petition No.: 4E8334 

DP Barcode: D431223 

Registration Nos.: 59639-3, 59639- 132 

Regulatory Action: Section 3 

Risk Assessment Type: Single 

Chemical/ Aggregate 

Case No.: NA 

TXR No.: NA CAS No.: 99129-21-2 

MRID No.: NA 40 CFR: § 180.458 

FROM: 

THROUGH: 

TO: 

Meheret Negussie, Chemist /ieiierd ~Cl"V-#<'e. 

Risk Assessment Branch Ill (RAB3) 

Health Effects Division (HED) (7509P) 

S

Don

Dietary 

heila 

ald 

Pip

Wilbur

Exposu

er, Sen

, 

r

S

e 

i

e

or 

Sc

nior 

ience 

Ch

emise

Adv

mist 

isory Cou~~C) 

\I 

~ ~ 

Chri tinaen~lin ge , Branch Chief ,iJ I/ Cf& 

RAB3/HED (7509P) {/7/ / .._ 

Laura Nollen, Biologist/Risk Assessor 

RA83/HED (7509P) 

and 

Barbara Madden/Sidney Jackson, RM #5 

Risk Integration, Minor Use, and Emergency Response Branch 

Registration Division (7505P) 

Page I of23 
Clethodim Dietary Exposure and Risk Assessment DP Number: 43 1223 

PC Code: 121011 

I. Executive Summary 

Acute and chronic aggregate dietary (food and drinking water) exposure and risk 

assessments were conducted using the Dietary Exposure Eva luation Model software with 

the Food Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 

2003-2008 food consumption data from the U.S. Department of Agriculture's (USDA's) 

National Health and Nutrition Examination Survey, What We Eat in America, 

(NHANES/WWEIA). The analyses were conducted in support of new uses on stevia; 

po me fruit crop croup 11 - 10: stone fruit crop group 12-12; and crop group/subgroup 

expansions for onion, bulb subgroup 3-07 A; fruiting vegetables crop group 8-10; Low 

growing subgroup 13-070, except cranberry; rapeseed subgroup 20A, except flax seed; 

and cottonseed subgroup 20C. This memorandum was reviewed by two peer reviewers 

of the DESAC, per DESAC SOP 2012. 1. 

Acute and Clu-onic Dietary (Food and Drinking Water) Exposure Results and 

Characterization 

Unrefined acute and chronic dietary analyses were conducted. The assumptions of the 

di etary assessment included tolerance levels for all commodities and l 00% crop treated 

(CT). DEEM version 7.81 default processing factors were assumed except for where 

tolerances were established for processed commodities. Estimated drinking water 

concentrations (EDWCs) were incorporated directly into the dietary assessment from 

ground water estimates obtained using the Pesticide Root Zone Model for Ground Water 

(PRZM-GW) model provided by the Environmental Fate and Effects Division (EFED). 

The acute dietary risk assessment shows that the acute dietary risk estimates are below 

HED's level of concern (LOC) (i.e., < 100% of the acute population adjusted dose 

(aPAO)). For the general U.S. population, the exposure for food and drinking water 

utilized 10% of the aPAD. The acute dietary risk estimate for the highest reported 

exposed population subgroup, all infants (< l year old), utilized 29% of the aPAD at the 

95111 percentile. 

The chronic dietary risk assessment shows that the chronic dietary risk estimates are 

below HED's LOC (i.e., < 100% of the chronic population adjusted dose (cPAD)). For 

the genera l U.S. population, the exposure for food and drinking water utilized 12% of the 

cP AD. The chronic dietary risk estimate for the highest reported exposed population 

subgroup, all infants (<l year old), utilized 30% of the cPAD. 

Cancer Dietary (rood and Drinking Water) Exposure 

Clcthodim has been classified as ''Not likely to be Carcinogenic to Humans" based no 

treatment-related increase in tumor incidence in rat and mouse carcinogenicity studies. 

Therefore, cancer risk was not assessed. 

Page 2 of23 
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 3 of 23

Introduction

Dietary risk assessment incorporates both exposure and toxicity for any given pesticide. 

For acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population-adjusted dose (PAD). 

The PAD is equivalent to the point of departure (POD); e.g. no observed adverse effect 

level (NOAEL), lowest observed adverse effect level (LOAEL), etc.) divided by the 

required uncertainty or safety factors.

For non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the cPAD. References which discuss chronic risk assessments in more 

detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf or see SOP 99.6 

(20-AUG-1999).

The most recent dietary risk assessment for clethodim was conducted by Nancy Dodd

(DP# D412296, 11/13/2013). 

II. Residue Information

Permanent tolerances have been established in 40 CFR §180.458 for the combined 

residues of clethodim and its metabolites containing the 5-(2-

ethylthiopropyl)cyclohexene-3-one and 5-(2-ethylthiopropyl)-5-hydroxycyclohexene-3-

one moieties and their sulphoxides and sulphones, expressed as clethodim in/on various 

raw agricultural commodities ranging from 0.2 ppm in livestock commodities to 20 ppm 

in clover, hay. The residues of concern for tolerance expression and risk assessment are 

the same. 

Table 1 presents the residue values for the proposed uses. The complete details of HED 

recommendations are presented in the summary document (DP# D425763, M. Negussie, 

01/13/2016). 

In general, pesticide residues would not be expected to be found in fish unless the 

pesticide bioaccumulates or has an aquatic use. To determine whether or not residues are 

present in fish, HED now routinely checks PDP monitoring data regardless of the 

pesticide’s uses and physicochemical properties. The USDA Pesticide Data Program 

(PDP) monitored pesticide residues in catfish in 2008, 2009, and 2010. PDP analyzed 

residues in salmon in 2013. However, the samples were not analyzed for clethodim. 

Residue Data used for Acute and Chronic Assessment:

Unrefined acute and chronic dietary analyses were conducted. The assumptions of the 

dietary assessment included tolerance levels for all commodities and 100% CT. 
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 4 of 23

DEEM default processing factors were used when available except for potato, dry 

(granules/flakes) and sesame oil, for which either a tolerance was established or an 

empirical processing factor was available. A 2.0 ppm tolerance was established on potato 

granules/flakes (DP#’s 240302 and 254018, M. Xue, 09/07/2000). A sesame oil 

processing factor of 1.4x was recommended by ARIA (D. Rate, DP#334913, 

02/09/2007). 

A processing study (J. Stokes, DP#333329, 09/09/2007) indicated that no separate 

tolerances or processing factors are required for the following field corn processed 

commodities: flour, meal, starch, grits, and refined oil. Stevia is not a commodity with 

reported consumption in DEEM. Additionally, based on previous decisions made by the 

ChemSAC (09/11/2013), we do not expect there to be residues in stevia (Rebaudioside A 

powder), and thus exposure is expected to be negligible. 

Table 1. Tolerance Summary for Clethodim.

Commodity Proposed 

Tolerance 

(ppm)

Recommended 

Tolerance 

(ppm)

Comments; Correct Commodity 

Definition

Onion, bulb Subgroup 3-07A 0.2 0.50 Onion, bulb, subgroup 3-07A

Fruiting Vegetables Group 08-

10

1.0 1.0 Vegetable, fruiting, Group 8-10

Pome Fruit Group 11-10 0.2 0.20 Fruit, pome, group 11-10

Stone Fruit Group 12-12 0.2 0.20 Fruit, stone, group 12-12

Low Growing Berry Subgroup 

13-07G, except Cranberry

3.0 3.0 Berry, low growing, subgroup 13-07G, 

except cranberry

Rapeseed subgroup 20A, except 

flax

0.5 0.50 Rapeseed subgroup 20A, except flax 

seed

Sunflower subgroup 20B 5.0 5.0

Cotton seed subgroup 20C 1.0 1.0 Cottonseed subgroup 20C

Stevia 12.0 12 Stevia, dried leaves

III. Percent Crop Treated Information

100% CT was assumed for all crops.

IV. Drinking Water Data

The drinking water residues used in the acute and chronic dietary risk assessment were 

provided by the Environmental Fate and Effects Division (EFED) in the following 

memorandum: “Clethodim: Drinking Water Exposure Assessment for Registration 

Review” (G. Orrick, DP# D425767, 03/31/2015 and DP#412704, 6/24/13) and 

incorporated directly into this dietary assessment. Water residues were incorporated in 

the DEEM-FCID into the food categories “water, direct, all sources” and “water, indirect, 

all sources.” 
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 5 of 23

Based on the proposed application rates and the environmental fate properties of 

clethodim, surface and ground water contamination may occur from clethodim as well as 

its sulfoxide and sulfone degradates. The risk of water contamination is primarily 

associated with clethodim sulfone and clethodim sulfoxide rather than parent clethodim 

based on greater persistence and mobility of these degradates. Thus, the assessments were

based on the total toxic residue rather than parent only.

The maximum screening-level acute and chronic EDWCs (1,430 and 1,150 μg/L, 

respectively) which are used in the dietary assessment are based on the maximum use 

pattern for clethodim (which includes non-cropped areas, fallow ground, and alfalfa), 

which includes a maximum annual application rate of 4.5 lbs a.i./A. The EDWCs are 

estimated with PRZM-GW to occur in an area of Wisconsin that is vulnerable to ground 

water contamination. These EDWCs are 43-53x greater than screening-level EDWCs for 

ground water from Screening Concentration In Ground Water (SCI-GROW) and 4-8x 

greater than screening-level EDWCs for surface water from FIRST (FQPA Index 

Reservoir Screening Tool) (Table 2). The variance with SCI-GROW may be due, in part, 

to 1) PRZM-GW being mechanistic, the SCI-GROW is empirical, and 2) differences in 

modeling assumptions such as the duration of the modeling scenario.

Table 2. Screening-Level ROC EDWCs for Clethodim Uses 1

Source (Tier: Model) Use Site

(Max. Annual App. Rate)

Acute 

(μg/L)

Chronic 

(μg/L)

Surface water (Tier I: FIRST) Non-cropped (4.5 lbs a.i./A) 330 137

Ground water (Tier I: PRZM-GW) Non-cropped (4.5 lbs a.i./A) 1,430 1,150

Ground water (Tier I: SCI-GROW) Non-cropped (4.5 lbs a.i./A) ≤27

1Maximum values in bold.

The models and their descriptions are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 

V. DEEM-FCID Program and Consumption Information

Clethodim acute and chronic dietary exposure assessments were conducted using the 

DEEM-FCID, Version 3.16, which incorporates 2003-2008 consumption data from 

USDA’s NHANES/WWEIA. The data are based on the reported consumption of more 

than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” 

(e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit -

cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly 

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic 

exposure assessment, consumption data are averaged for the entire U.S. population and 

within population subgroups. However, for acute exposure assessment, consumption 

data are retained as individual consumption events. Based on analysis of the 2003-2008 

WWEIA consumption data, which took into account dietary patterns and survey 

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 6 of 23

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 

years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the cPAD. This procedure is performed for each 

population subgroup.

VI. Toxicological Information

The toxicity endpoints pertinent for human dietary risk assessment are summarized in 

Table 3. 

Table 3. Summary of Toxicological Doses and Endpoints for Clethodim for Use in Dietary 

Exposure Risk Assessments.

Exposure/

Scenario

Point of 

Departure

Uncertainty/

FQPA Safety 

Factors

RfD, PAD, Level 

of Concern for 

Risk Assessment

Study and Toxicological 

Effects

Acute Dietary

(All 

Populations)

NOAEL 

=100 

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 

1X

Acute RfD = 1 

mg/kg/day

aPAD= 1 

mg/kg/day

Acute neurotoxicity studiesrats

LOAEL =1000 mg/kg based 

on clinical observation from 

two acute neurotoxicity 

studies (one study was 

conducted in 2006 and the 

current study, completed in 

2012). The clinical 

observation included 

decreased spontaneous 

activity, ruffled fur, head tilt, 

and hunched posture.

Chronic 

Dietary

(All 

Populations)

NOAEL = 

30 

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 

1X

Chronic RfD = 

0.3mg/kg/day

cPAD = 0.3 

mg/kg/day

Carcinogenicity study-mice

LOAEL=150 mg/kg/day 

based on reduced survival; 

decreased red cell mass; and 

increased incidences of bile 

duct hyperplasia, of 

pigmentation of the liver, and 

of foci of amphophilic 

macrophages in the lung.

Cancer 

(oral, dermal, 

inhalation)

Clethodim is classified as "Not Likely" to be carcinogenic based no treatment-related 

increase in tumor incidence in rat and mouse carcinogenicity studies.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response 

data and used to mark the beginning of extrapolation to determine risk associated with lower 

environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest 

observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from animal to human 
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 7 of 23

(interspecies). UFH = potential variation in sensitivity among members of the human population 

(intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). 

RfD = reference dose. 

VII. Results/Discussion 

Results of Acute and Chronic Dietary (Food and Drinking Water) Exposure Analysis

As stated above, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure of 

the U.S. population and various population subgroups. The results reported in Table 4

are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, 

children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years.

The acute dietary exposure for food and drinking water utilized 10% of the aPAD for the 

general U.S. population. The acute dietary exposure for the highest reported exposed 

population subgroup, all infants (<1 year old), utilized 29% of the aPAD at the 95th

percentile.

 

The chronic dietary exposure for food and drinking water utilized 12% of the cPAD for 

the general U.S. population. The chronic dietary exposure for the highest reported 

exposed population subgroup, all infants (<1 year old), utilized 30% of the cPAD.

The results of the acute and chronic dietary exposure analyses are reported in Table 4

below.

Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Clethodim.

Population Subgroup

Acute Dietary

95th% percentile Chronic Dietary

Dietary 

(mg/kg/day) % aPAD Dietary Exposure(mg/kg/day) % cPAD

General U.S. Population 0.102035 10 0.037592 12

All Infants (< 1 year old) 0.286813 29 0.090304 30

Children 1-2 years old 0.177502 18 0.074277 25

Children 3-5 years old 0.157066 16 0.061470 20

Children 6-12 years old 0.105444 10 0.040639 14

Youth 13-19 years old 0.080662 8.1 0.028696 9.6

Adults 20-49 years old 0.094225 9.4 0.034796 12

Adults 50-99 years old 0.084808 8.5 0.034303 11

Females 13-49 years old 0.094612 9.5 0.034543 12

 aPAD= 1 mkd; cPAD= 0.3 mkd; Highest Exposure values are bolded.
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 8 of 23

VIII. Characterization of Inputs/Outputs

The acute and chronic dietary exposure assessment is unrefined, i.e., based on the 

assumption of tolerance-level residues for all commodities and 100% CT. Refinement to 

the analyses could be made through the use of anticipated residues, %CT data, empirical 

processing factors, and monitoring data. Since risk estimates are below HED’s level of 

concern, a refined analysis is not needed at this time.

IX. Conclusions

The acute and chronic dietary analyses demonstrate that the exposure from the existing 

and requested uses for clethodim will not result in dietary risk estimates that exceed 

HED’s level of concern for any of the regulated population subgroups, including those

comprised of infants and children.
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 9 of 23

X. List of Attachments

Attachment 1: Acute Food and Water Residue Input File

Attachment 2: Acute Food and Water Results File

Attachment 3: Chronic Food and Water Residue Input File

Attachment 4: Chronic Food and Water Results File
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 10 of 23

Attachment 1: Acute Food and Water Residue Input File

Filename: C:\Users\mnegussi\Documents\DEEM Version 3.16\Clethodim\New 

folder\AcuteClethodim2016.R08

Chemical: Clethodim

RfD(Chronic): 0.3 mg/kg bw/day NOEL(Chronic): 30 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day

Date created/last modified: 01-13-2016/12:30:46 Program ver. 3.16, 03-08-d

Comment: New Acute Reference Dose; New uses-apple, pear, cherry, plum and crop group 

expansion

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101050000 1AB Beet, garden, roots 1.000000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 1.000000 1.000 1.000 

0101052000 1A Beet, sugar 0.200000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.200000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 1.000000 1.000 1.000 

0101053001 1A Beet, sugar, molasses-babyfood 1.000000 1.000 1.000 

0101067000 1AB Burdock 1.000000 1.000 1.000 

0101078000 1AB Carrot 1.000000 1.000 1.000 

0101078001 1AB Carrot-babyfood 1.000000 1.000 1.000 

0101079000 1AB Carrot, juice 1.000000 1.000 1.000 

0101084000 1AB Celeriac 1.000000 1.000 1.000 

0101100000 1AB Chicory, roots 1.000000 1.000 1.000 

0101168000 1AB Ginseng, dried 1.000000 1.000 1.000 

0101190000 1AB Horseradish 1.000000 1.000 1.000 

0101250000 1AB Parsley, turnip rooted 1.000000 1.000 1.000 

0101251000 1AB Parsnip 1.000000 1.000 1.000 

0101251001 1AB Parsnip-babyfood 1.000000 1.000 1.000 

0101314000 1AB Radish, roots 1.000000 1.000 1.000 

0101316000 1AB Radish, Oriental, roots 1.000000 1.000 1.000 

0101327000 1AB Rutabaga 1.000000 1.000 1.000 

0101331000 1AB Salsify, roots 1.000000 1.000 1.000 

0101388000 1AB Turnip, roots 1.000000 1.000 1.000 

0103015000 1CD Arrowroot, flour 1.000000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 1.000000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 1.000000 1.000 1.000 

0103082000 1CD Cassava 1.000000 1.000 1.000 

0103082001 1CD Cassava-babyfood 1.000000 1.000 1.000 

0103139000 1CD Dasheen, corm 1.000000 1.000 1.000 

0103166000 1CD Ginger 1.000000 1.000 1.000 

0103166001 1CD Ginger-babyfood 1.000000 1.000 1.000 

0103167000 1CD Ginger, dried 1.000000 1.000 1.000 

0103296000 1C Potato, chips 1.000000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 2.000000 1.000 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 2.000000 1.000 1.000 

0103298000 1C Potato, flour 1.000000 6.500 1.000 

0103298001 1C Potato, flour-babyfood 1.000000 6.500 1.000 

0103299000 1C Potato, tuber, w/peel 1.000000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 1.000000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 1.000000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 1.000000 1.000 1.000 

0103366000 1CD Sweet potato 1.000000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 1.000000 1.000 1.000 

0103371000 1CD Tanier, corm 1.000000 1.000 1.000 

0103387000 1CD Turmeric 1.000000 1.000 1.000 

0103406000 1CD Yam, true 1.000000 1.000 1.000 

0103407000 1CD Yam bean 1.000000 1.000 1.000 

0200315000 2 Radish, tops 0.700000 1.000 1.000 

0200317000 2 Radish, Oriental, tops 0.700000 1.000 1.000 

0200332000 2 Salsify, tops 0.700000 1.000 1.000 

0301165000 3A Garlic, bulb 0.500000 1.000 1.000 D42576

 Full comment: D425763
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 11 of 23

0301165001 3A Garlic, bulb-babyfood 0.500000 1.000 1.000 

0301237000 3A Onion, bulb 0.500000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.500000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.500000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.500000 9.000 1.000 

0301338000 3A Shallot, bulb 0.500000 1.000 1.000 

0302103000 3B Chive, fresh leaves 12.000000 1.000 1.000 4E6836

0302239000 3B Onion, green 2.000000 1.000 1.000 

0401005000 4A Amaranth, leafy 2.000000 1.000 1.000 5E6978

0401018000 4A Arugula 2.000000 1.000 1.000 5E6978

0401104000 4A Chrysanthemum, garland 2.000000 1.000 1.000 5E6978

0401133000 4A Cress, garden 2.000000 1.000 1.000 5E6978

0401134000 4A Cress, upland 2.000000 1.000 1.000 5E6978

0401138000 4A Dandelion, leaves 2.000000 1.000 1.000 5E6978

0401150000 4A Endive 2.000000 1.000 1.000 5E6978

0401204000 4A Lettuce, head 2.000000 1.000 1.000 5E6978

0401205000 4A Lettuce, leaf 2.000000 1.000 1.000 5E6978

0401248000 4A Parsley, leaves 2.000000 1.000 1.000 5E6978

0401313000 4A Radicchio 2.000000 1.000 1.000 5E6978

0401355000 4A Spinach 2.000000 1.000 1.000 5E6978

0401355001 4A Spinach-babyfood 2.000000 1.000 1.000 5E6978

0402076000 4B Cardoon 0.600000 1.000 1.000 

0402085000 4B Celery 0.600000 1.000 1.000 

0402085001 4B Celery-babyfood 0.600000 1.000 1.000 

0402086000 4B Celery, juice 0.600000 1.000 1.000 

0402087000 4B Celtuce 0.600000 1.000 1.000 

0402152000 4B Fennel, Florence 0.600000 1.000 1.000 

0402322000 4B Rhubarb 0.600000 1.000 1.000 

0402367000 4B Swiss chard 0.600000 1.000 1.000 

0501061000 5A Broccoli 3.000000 1.000 1.000 

0501061001 5A Broccoli-babyfood 3.000000 1.000 1.000 

0501062000 5A Broccoli, Chinese 3.000000 1.000 1.000 

0501064000 5A Brussels sprouts 3.000000 1.000 1.000 

0501069000 5A Cabbage 3.000000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 3.000000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 3.000000 1.000 1.000 

0501083000 5A Cauliflower 3.000000 1.000 1.000 

0501196000 5A Kohlrabi 3.000000 1.000 1.000 

0502063000 5B Broccoli raab 3.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 3.000000 1.000 1.000 

0502117000 5B Collards 3.000000 1.000 1.000 

0502194000 5B Kale 3.000000 1.000 1.000 

0502229000 5B Mustard greens 3.000000 1.000 1.000 

0502318000 5B Rape greens 3.000000 1.000 1.000 

0502389000 5B Turnip, greens 3.000000 1.000 1.000 

0600347000 6 Soybean, seed 10.000000 1.000 1.000 

0600349000 6 Soybean, soy milk 10.000000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 10.000000 1.000 1.000 

0600350000 6 Soybean, oil 10.000000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 10.000000 1.000 1.000 

0601043000 6A Bean, snap, succulent 3.500000 1.000 1.000 4F6895

 Full comment: 4F6895 

0601043001 6A Bean, snap, succulent-babyfood 3.500000 1.000 1.000 4F6895

 Full comment: 4F6895 

0601257000 6A Pea, edible podded, succulent 3.500000 1.000 1.000 4F6895

0601349500 6AB Soybean, vegetable 10.000000 1.000 1.000 

0602031000 6B Bean, broad, succulent 3.500000 1.000 1.000 4F6895

0602033000 6B Bean, cowpea, succulent 3.500000 1.000 1.000 4F6895

0602037000 6B Bean, lima, succulent 3.500000 1.000 1.000 4F6895

0602255000 6B Pea, succulent 3.500000 1.000 1.000 4F6895

0602255001 6B Pea, succulent-babyfood 3.500000 1.000 1.000 4F6895

0602259000 6B Pea, pigeon, succulent 3.500000 1.000 1.000 4F6895

0603030000 6C Bean, black, seed 3.500000 1.000 1.000 4F6895

0603032000 6C Bean, broad, seed 3.500000 1.000 1.000 4F6895

0603034000 6C Bean, cowpea, seed 3.500000 1.000 1.000 4F6895

0603035000 6C Bean, great northern, seed 3.500000 1.000 1.000 4F6895
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 12 of 23

0603036000 6C Bean, kidney, seed 3.500000 1.000 1.000 4F6895

0603038000 6C Bean, lima, seed 3.500000 1.000 1.000 4F6895

0603039000 6C Bean, mung, seed 3.500000 1.000 1.000 4F6895

0603040000 6C Bean, navy, seed 3.500000 1.000 1.000 4F6895

0603041000 6C Bean, pink, seed 3.500000 1.000 1.000 4F6895

0603042000 6C Bean, pinto, seed 3.500000 1.000 1.000 4F6895

0603098000 6C Chickpea, seed 3.500000 1.000 1.000 4F6895

0603098001 6C Chickpea, seed-babyfood 3.500000 1.000 1.000 4F6895

0603099000 6C Chickpea, flour 3.500000 1.000 1.000 4F6895

0603182000 6C Guar, seed 3.500000 1.000 1.000 4F6895

0603182001 6C Guar, seed-babyfood 3.500000 1.000 1.000 4F6895

0603203000 6C Lentil, seed 3.500000 1.000 1.000 4F6895

0603256000 6C Pea, dry 3.500000 1.000 1.000 4F6895

0603256001 6C Pea, dry-babyfood 3.500000 1.000 1.000 4F6895

0603258000 6C Pea, pigeon, seed 3.500000 1.000 1.000 4F6895

0603348000 6C Soybean, flour 10.000000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 10.000000 1.000 1.000 

0801374000 8A Tomatillo 1.000000 1.000 1.000 

0801375000 8A Tomato 1.000000 1.000 1.000 

0801375001 8A Tomato-babyfood 1.000000 1.000 1.000 

0801376000 8A Tomato, paste 1.000000 5.400 1.000 previo

 Full comment: previous tolerance expired 4/30/03

0801376001 8A Tomato, paste-babyfood 1.000000 5.400 1.000 previo

 Full comment: previous tolerance expired 4/30/03

0801377000 8A Tomato, puree 1.000000 3.300 1.000 previo

 Full comment: previous tolerance expired 4/30/03

0801377001 8A Tomato, puree-babyfood 1.000000 3.300 1.000 previo

 Full comment: previous tolerance expired 4/30/03

0801378000 8A Tomato, dried 1.000000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 1.000000 14.300 1.000 

0801379000 8A Tomato, juice 1.000000 1.500 1.000 

0801380000 8A Tomato, Tree 1.000000 1.000 1.000 

0802148000 8BC Eggplant 1.000000 1.000 1.000 

0802234000 8BC Okra 1.000000 1.000 1.000 

0802270000 8B Pepper, bell 1.000000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 1.000000 1.000 1.000 

0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 1.000000 1.000 1.000 

0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 1.000000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 

0901075000 9A Cantaloupe 2.000000 1.000 1.000 

0901187000 9A Honeydew melon 2.000000 1.000 1.000 

0901399000 9A Watermelon 2.000000 1.000 1.000 

0901400000 9A Watermelon, juice 2.000000 1.000 1.000 

0902021000 9B Balsam pear 0.500000 1.000 1.000 

0902088000 9B Chayote, fruit 0.500000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.500000 1.000 1.000 

0902135000 9B Cucumber 0.500000 1.000 1.000 

0902308000 9B Pumpkin 0.500000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 

0902356000 9B Squash, summer 0.500000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.500000 1.000 1.000 

0902357000 9B Squash, winter 0.500000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.500000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.200000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.200000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.200000 1.000 1.000 

1100009000 11 Apple, dried 0.200000 8.000 1.000 D42576

 Full comment: D425763

1100009001 11 Apple, dried-babyfood 0.200000 8.000 1.000 

1100010000 11 Apple, juice 0.200000 1.300 1.000 

1100010001 11 Apple, juice-babyfood 0.200000 1.300 1.000 

1100011000 11 Apple, sauce 0.200000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.200000 1.000 1.000 

1100129000 11 Crabapple 0.200000 1.000 1.000 
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 13 of 23

1100173500 11 Goji berry 1.000000 1.000 1.000 

1100210000 11 Loquat 0.200000 1.000 1.000 

1100266000 11 Pear 0.200000 1.000 1.000 D42576

 Full comment: D425763

1100266001 11 Pear-babyfood 0.200000 1.000 1.000 

1100267000 11 Pear, dried 0.200000 6.250 1.000 

1100268000 11 Pear, juice 0.200000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.200000 1.000 1.000 

1100310000 11 Quince 0.200000 1.000 1.000 

1201090000 12A Cherry 0.200000 1.000 1.000 D42576

 Full comment: D425763

1201090001 12A Cherry-babyfood 0.200000 1.000 1.000 

1201091000 12A Cherry, juice 0.200000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 0.200000 1.500 1.000 

1202012000 12B Apricot 0.200000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.200000 1.000 1.000 

1202013000 12B Apricot, dried 0.200000 6.000 1.000 

1202014000 12B Apricot, juice 0.200000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.200000 1.000 1.000 

1202230000 12B Nectarine 0.200000 1.000 1.000 

1202260000 12B Peach 0.200000 1.000 1.000 

1202260001 12B Peach-babyfood 0.200000 1.000 1.000 

1202261000 12B Peach, dried 0.200000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 0.200000 7.000 1.000 

1202262000 12B Peach, juice 0.200000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.200000 1.000 1.000 

1203285000 12C Plum 0.200000 1.000 1.000 

1203285001 12C Plum-babyfood 0.200000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.200000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.200000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.200000 5.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 0.200000 5.000 1.000 

1203288000 12C Plum, prune, juice 0.200000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.200000 1.400 1.000 

1301055000 13A Blackberry 0.300000 1.000 1.000 

1301056000 13A Blackberry, juice 0.300000 1.000 1.000 

1301056001 13A Blackberry, juice-babyfood 0.300000 1.000 1.000 

1301058000 13A Boysenberry 0.300000 1.000 1.000 

1301208000 13A Loganberry 0.300000 1.000 1.000 

1301320000 13A Raspberry 0.300000 1.000 1.000 

1301320001 13A Raspberry-babyfood 0.300000 1.000 1.000 

1301321000 13A Raspberry, juice 0.300000 1.000 1.000 

1301321001 13A Raspberry, juice-babyfood 0.300000 1.000 1.000 

1302057000 13B Blueberry 0.200000 1.000 1.000 

1302057001 13B Blueberry-babyfood 0.200000 1.000 1.000 

1302136000 13B Currant 0.200000 1.000 1.000 

1302137000 13B Currant, dried 0.200000 1.000 1.000 

1302149000 13B Elderberry 0.200000 1.000 1.000 

1302174000 13B Gooseberry 0.200000 1.000 1.000 

1302191000 13B Huckleberry 0.200000 1.000 1.000 

1307130000 13G Cranberry 0.500000 1.000 1.000 

1307130001 13G Cranberry-babyfood 0.500000 1.000 1.000 

1307131000 13G Cranberry, dried 0.500000 1.000 1.000 

1307132000 13G Cranberry, juice 0.500000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 0.500000 1.100 1.000 

1307359000 13G Strawberry 3.000000 1.000 1.000 D42576

 Full comment: D425763

1307359001 13G Strawberry-babyfood 3.000000 1.000 1.000 

1307360000 13G Strawberry, juice 3.000000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 3.000000 1.000 1.000 

1500120000 15 Corn, field, flour 0.200000 1.000 1.000 6F7117

1500120001 15 Corn, field, flour-babyfood 0.200000 1.000 1.000 6F7117

1500121000 15 Corn, field, meal 0.200000 1.000 1.000 6F7117

1500121001 15 Corn, field, meal-babyfood 0.200000 1.000 1.000 6F7117

1500122000 15 Corn, field, bran 0.200000 1.000 1.000 6F7117

1500123000 15 Corn, field, starch 0.200000 1.000 1.000 6F7117
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 14 of 23

1500123001 15 Corn, field, starch-babyfood 0.200000 1.000 1.000 6F7117

1500124000 15 Corn, field, syrup 0.200000 1.500 1.000 6F7117

1500124001 15 Corn, field, syrup-babyfood 0.200000 1.500 1.000 6F7117

1500125000 15 Corn, field, oil 0.200000 1.000 1.000 6F7117

1500125001 15 Corn, field, oil-babyfood 0.200000 1.000 1.000 6F7117

1901028000 19A Basil, fresh leaves 12.000000 1.000 1.000 4E6836

1901028001 19A Basil, fresh leaves-babyfood 12.000000 1.000 1.000 4E6836

1901029000 19A Basil, dried leaves 12.000000 1.000 1.000 4E6836

1901029001 19A Basil, dried leaves-babyfood 12.000000 1.000 1.000 4E6836

1901102500 19A Chive, dried leaves 12.000000 1.000 1.000 

1901118000 19A Cilantro, leaves 12.000000 1.000 1.000 4E6936

1901118001 19A Cilantro, leaves-babyfood 12.000000 1.000 1.000 4E6936

1901144000 19A Dillweed 12.000000 1.000 1.000 4E6836

1901184000 19A Herbs, other 12.000000 1.000 1.000 4E6836

1901184001 19A Herbs, other-babyfood 12.000000 1.000 1.000 4E6836

1901202000 19A Lemongrass 12.000000 1.000 1.000 4E6836

1901220000 19A Marjoram 12.000000 1.000 1.000 4E6836

1901220001 19A Marjoram-babyfood 12.000000 1.000 1.000 4E6836

1901249000 19A Parsley, dried leaves 12.000000 1.000 1.000 4E6836

1901249001 19A Parsley, dried leaves-babyfood 12.000000 1.000 1.000 4E6836

1901334000 19A Savory 12.000000 1.000 1.000 4E6836

2001163000 20A Flax seed, oil 0.600000 1.000 1.000 

2001319000 20A Rapeseed, oil 0.500000 1.000 1.000 D42576

 Full comment: D425763

2001319001 20A Rapeseed, oil-babyfood 0.500000 1.000 1.000 

2001336000 20A Sesame, seed 0.500000 1.000 1.000 

2001336001 20A Sesame, seed-babyfood 0.500000 1.000 1.000 

2001337000 20A Sesame, oil 0.500000 1.400 1.000 

2001337001 20A Sesame, oil-babyfood 0.500000 1.400 1.000 

2002330000 20B Safflower, oil 5.000000 1.000 1.000 D42576

 Full comment: D425763

2002330001 20B Safflower, oil-babyfood 5.000000 1.000 1.000 

2002364000 20B Sunflower, seed 5.000000 1.000 1.000 

2002365000 20B Sunflower, oil 5.000000 1.000 1.000 

2002365001 20B Sunflower, oil-babyfood 5.000000 1.000 1.000 

2003114001 20C Coconut, oil-babyfood 1.000000 1.000 1.000 D42576

 Full comment: D425763

2003128000 20C Cottonseed, oil 1.000000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 1.000000 1.000 1.000 

3100044000 31 Beef, meat 0.200000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.200000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.200000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.200000 1.000 1.000 

3100047000 31 Beef, fat 0.200000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.200000 1.000 1.000 

3100048000 31 Beef, kidney 0.200000 1.000 1.000 

3100049000 31 Beef, liver 0.200000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.200000 1.000 1.000 

3200169000 32 Goat, meat 0.200000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000 

3200171000 32 Goat, fat 0.200000 1.000 1.000 

3200172000 32 Goat, kidney 0.200000 1.000 1.000 

3200173000 32 Goat, liver 0.200000 1.000 1.000 

3300189000 33 Horse, meat 0.200000 1.000 1.000 

3400290000 34 Pork, meat 0.200000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.200000 1.000 1.000 

3400291000 34 Pork, skin 0.200000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.200000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.200000 1.000 1.000 

3400293000 34 Pork, fat 0.200000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.200000 1.000 1.000 

3400294000 34 Pork, kidney 0.200000 1.000 1.000 

3400295000 34 Pork, liver 0.200000 1.000 1.000 

3500339000 35 Sheep, meat 0.200000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.200000 1.000 1.000 
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 15 of 23

3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 

3500341000 35 Sheep, fat 0.200000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.200000 1.000 1.000 

3500342000 35 Sheep, kidney 0.200000 1.000 1.000 

3500343000 35 Sheep, liver 0.200000 1.000 1.000 

3600222000 36 Milk, fat 0.050000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.050000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.050000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 

3600224000 36 Milk, water 0.050000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.050000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 

4000093000 40 Chicken, meat 0.200000 1.000 1.000 

4000093001 40 Chicken, meat-babyfood 0.200000 1.000 1.000 

4000094000 40 Chicken, liver 0.200000 1.000 1.000 

4000095000 40 Chicken, meat byproducts 0.200000 1.000 1.000 

4000095001 40 Chicken, meat byproducts-babyfoo 0.200000 1.000 1.000 

4000096000 40 Chicken, fat 0.200000 1.000 1.000 

4000096001 40 Chicken, fat-babyfood 0.200000 1.000 1.000 

4000097000 40 Chicken, skin 0.200000 1.000 1.000 

4000097001 40 Chicken, skin-babyfood 0.200000 1.000 1.000 

5000382000 50 Turkey, meat 0.200000 1.000 1.000 

5000382001 50 Turkey, meat-babyfood 0.200000 1.000 1.000 

5000383000 50 Turkey, liver 0.200000 1.000 1.000 

5000383001 50 Turkey, liver-babyfood 0.200000 1.000 1.000 

5000384000 50 Turkey, meat byproducts 0.200000 1.000 1.000 

5000384001 50 Turkey, meat byproducts-babyfood 0.200000 1.000 1.000 

5000385000 50 Turkey, fat 0.200000 1.000 1.000 

5000385001 50 Turkey, fat-babyfood 0.200000 1.000 1.000 

5000386000 50 Turkey, skin 0.200000 1.000 1.000 

5000386001 50 Turkey, skin-babyfood 0.200000 1.000 1.000 

6000301000 60 Poultry, other, meat 0.200000 1.000 1.000 

6000302000 60 Poultry, other, liver 0.200000 1.000 1.000 

6000303000 60 Poultry, other, meat byproducts 0.200000 1.000 1.000 

6000304000 60 Poultry, other, fat 0.200000 1.000 1.000 

6000305000 60 Poultry, other, skin 0.200000 1.000 1.000 

7000145000 70 Egg, whole 0.200000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.200000 1.000 1.000 

7000146000 70 Egg, white 0.200000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.200000 1.000 1.000 

7000147000 70 Egg, yolk 0.200000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.200000 1.000 1.000 

8601000000 86A Water, direct, all sources 1.430000 1.000 1.000 

8602000000 86B Water, indirect, all sources 1.430000 1.000 1.000 

9500016000 O Artichoke, globe 1.200000 1.000 1.000 

9500019000 O Asparagus 1.700000 1.000 1.000 5E6977

9500188000 O Hop 0.500000 1.000 1.000 5E6977

9500263000 O Peanut 3.000000 1.000 1.000 

9500264000 O Peanut, butter 3.000000 1.890 1.000 

9500265000 O Peanut, oil 3.000000 1.000 1.000 

9500275000 O Peppermint 5.000000 1.000 1.000 

9500276000 O Peppermint, oil 5.000000 1.000 1.000 

9500352000 O Spearmint 5.000000 1.000 1.000 

9500353000 O Spearmint, oil 5.000000 1.000 1.000 
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 16 of 23

Attachment 2: Acute Food and Water Results File

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for CLETHODIM NHANES 2003-2008 2-Day

Residue file: AcuteClethodim2016.R08 Adjustment factor #2 NOT used.

Analysis Date: 01-19-2016/11:39:19 Residue file dated: 01-19-2016/11:36:41

NOEL (Acute) = 100.000000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

Run Comment: "New Acute Reference Dose; New SLUA not used; New uses-apple, pea

r, cherry, plum and crop group expansion"

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Total US Population:

 0.102035 10.20 980 0.167895 16.79 595 0.319699 31.97 312 

All Infants:

 0.286813 28.68 348 0.398209 39.82 251 0.527687 52.77 189 

Female 13-50:

 0.094461 9.45 1058 0.137324 13.73 728 0.191331 19.13 522 

Children 1-2:

 0.177502 17.75 563 0.355548 35.55 281 0.906317 90.63 110 

Children 3-5:

 0.157066 15.71 636 0.225863 22.59 442 0.515648 51.56 193 

Children 6-12:

 0.105444 10.54 948 0.176090 17.61 567 0.326669 32.67 306 

Youth 13-19:

 0.080662 8.07 1239 0.130928 13.09 763 0.181832 18.18 549 

Adults 20-49:

 0.094225 9.42 1061 0.137011 13.70 729 0.185488 18.55 539 

Adults 50-99:

 0.084808 8.48 1179 0.127349 12.73 785 0.195200 19.52 512 

Female 13-49:

 0.094612 9.46 1056 0.137415 13.74 727 0.186638 18.66 535 
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 17 of 23

Attachment 3: Chronic Food and Water Residue Input File

Filename: C:\Users\mnegussi\Documents\DEEM Version 3.16\Clethodim\New 

folder\ChronicClethodim2016.R08

Chemical: Clethodim

RfD(Chronic): .3 mg/kg bw/day NOEL(Chronic): 30 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 01-19-2016/11:42:54 Program ver. 3.16, 03-08-d

Comment: New Chronic Reference Dose; New SLUA not used; New uses apple, pear, 

cherry, plum and crop group expansion; 

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101050000 1AB Beet, garden, roots 1.000000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 1.000000 1.000 1.000 

0101052000 1A Beet, sugar 0.200000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.200000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 1.000000 1.000 1.000 

0101053001 1A Beet, sugar, molasses-babyfood 1.000000 1.000 1.000 

0101067000 1AB Burdock 1.000000 1.000 1.000 

0101078000 1AB Carrot 1.000000 1.000 1.000 

0101078001 1AB Carrot-babyfood 1.000000 1.000 1.000 

0101079000 1AB Carrot, juice 1.000000 1.000 1.000 

0101084000 1AB Celeriac 1.000000 1.000 1.000 

0101100000 1AB Chicory, roots 1.000000 1.000 1.000 

0101168000 1AB Ginseng, dried 1.000000 1.000 1.000 

0101190000 1AB Horseradish 1.000000 1.000 1.000 

0101250000 1AB Parsley, turnip rooted 1.000000 1.000 1.000 

0101251000 1AB Parsnip 1.000000 1.000 1.000 

0101251001 1AB Parsnip-babyfood 1.000000 1.000 1.000 

0101314000 1AB Radish, roots 1.000000 1.000 1.000 

0101316000 1AB Radish, Oriental, roots 1.000000 1.000 1.000 

0101327000 1AB Rutabaga 1.000000 1.000 1.000 

0101331000 1AB Salsify, roots 1.000000 1.000 1.000 

0101388000 1AB Turnip, roots 1.000000 1.000 1.000 

0103015000 1CD Arrowroot, flour 1.000000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 1.000000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 1.000000 1.000 1.000 

0103082000 1CD Cassava 1.000000 1.000 1.000 

0103082001 1CD Cassava-babyfood 1.000000 1.000 1.000 

0103139000 1CD Dasheen, corm 1.000000 1.000 1.000 

0103166000 1CD Ginger 1.000000 1.000 1.000 

0103166001 1CD Ginger-babyfood 1.000000 1.000 1.000 

0103167000 1CD Ginger, dried 1.000000 1.000 1.000 

0103296000 1C Potato, chips 1.000000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 2.000000 1.000 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 2.000000 1.000 1.000 

0103298000 1C Potato, flour 1.000000 6.500 1.000 

0103298001 1C Potato, flour-babyfood 1.000000 6.500 1.000 

0103299000 1C Potato, tuber, w/peel 1.000000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 1.000000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 1.000000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 1.000000 1.000 1.000 

0103366000 1CD Sweet potato 1.000000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 1.000000 1.000 1.000 

0103371000 1CD Tanier, corm 1.000000 1.000 1.000 

0103387000 1CD Turmeric 1.000000 1.000 1.000 

0103406000 1CD Yam, true 1.000000 1.000 1.000 

0103407000 1CD Yam bean 1.000000 1.000 1.000 

0200315000 2 Radish, tops 0.700000 1.000 1.000 

0200317000 2 Radish, Oriental, tops 0.700000 1.000 1.000 

0301165000 3A Garlic, bulb 0.500000 1.000 1.000 D42576

 Full comment: D425763
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 18 of 23

0301165001 3A Garlic, bulb-babyfood 0.500000 1.000 1.000 

0301237000 3A Onion, bulb 0.500000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.500000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.500000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.500000 9.000 1.000 

0301338000 3A Shallot, bulb 0.500000 1.000 1.000 

0302103000 3B Chive, fresh leaves 12.000000 1.000 1.000 4E6836

0302239000 3B Onion, green 2.000000 1.000 1.000 

0401005000 4A Amaranth, leafy 2.000000 1.000 1.000 5E6978

0401018000 4A Arugula 2.000000 1.000 1.000 5E6978

0401104000 4A Chrysanthemum, garland 2.000000 1.000 1.000 5E6978

0401133000 4A Cress, garden 2.000000 1.000 1.000 5E6978

0401134000 4A Cress, upland 2.000000 1.000 1.000 5E6978

0401138000 4A Dandelion, leaves 2.000000 1.000 1.000 5E6978

0401150000 4A Endive 2.000000 1.000 1.000 5E6978

0401204000 4A Lettuce, head 2.000000 1.000 1.000 5E6978

0401205000 4A Lettuce, leaf 2.000000 1.000 1.000 5E6978

0401248000 4A Parsley, leaves 2.000000 1.000 1.000 5E6978

0401313000 4A Radicchio 2.000000 1.000 1.000 5E6978

0401355000 4A Spinach 2.000000 1.000 1.000 5E6978

0401355001 4A Spinach-babyfood 2.000000 1.000 1.000 5E6978

0402076000 4B Cardoon 0.600000 1.000 1.000 

0402085000 4B Celery 0.600000 1.000 1.000 

0402085001 4B Celery-babyfood 0.600000 1.000 1.000 

0402086000 4B Celery, juice 0.600000 1.000 1.000 

0402087000 4B Celtuce 0.600000 1.000 1.000 

0402152000 4B Fennel, Florence 0.600000 1.000 1.000 

0402322000 4B Rhubarb 0.600000 1.000 1.000 

0402367000 4B Swiss chard 0.600000 1.000 1.000 

0501061000 5A Broccoli 3.000000 1.000 1.000 

0501061001 5A Broccoli-babyfood 3.000000 1.000 1.000 

0501062000 5A Broccoli, Chinese 3.000000 1.000 1.000 

0501064000 5A Brussels sprouts 3.000000 1.000 1.000 

0501069000 5A Cabbage 3.000000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 3.000000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 3.000000 1.000 1.000 

0501083000 5A Cauliflower 3.000000 1.000 1.000 

0501196000 5A Kohlrabi 3.000000 1.000 1.000 

0502063000 5B Broccoli raab 3.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 3.000000 1.000 1.000 

0502117000 5B Collards 3.000000 1.000 1.000 

0502194000 5B Kale 3.000000 1.000 1.000 

0502229000 5B Mustard greens 3.000000 1.000 1.000 

0502318000 5B Rape greens 3.000000 1.000 1.000 

0502389000 5B Turnip, greens 3.000000 1.000 1.000 

0600347000 6 Soybean, seed 10.000000 1.000 1.000 

0600349000 6 Soybean, soy milk 10.000000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 10.000000 1.000 1.000 

0600350000 6 Soybean, oil 10.000000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 10.000000 1.000 1.000 

0601043000 6A Bean, snap, succulent 3.500000 1.000 1.000 4F6895

0601043001 6A Bean, snap, succulent-babyfood 3.500000 1.000 1.000 4F6895

0601257000 6A Pea, edible podded, succulent 3.500000 1.000 1.000 4F6895

0602031000 6B Bean, broad, succulent 3.500000 1.000 1.000 4F6895

0602033000 6B Bean, cowpea, succulent 3.500000 1.000 1.000 4F6895

0602037000 6B Bean, lima, succulent 3.500000 1.000 1.000 4F6895

0602255000 6B Pea, succulent 3.500000 1.000 1.000 4F6895

0602255001 6B Pea, succulent-babyfood 3.500000 1.000 1.000 4F6895

0602259000 6B Pea, pigeon, succulent 3.500000 1.000 1.000 4F6895

0603030000 6C Bean, black, seed 3.500000 1.000 1.000 4F6895

0603032000 6C Bean, broad, seed 3.500000 1.000 1.000 4F6895

0603034000 6C Bean, cowpea, seed 3.500000 1.000 1.000 4F6895

0603035000 6C Bean, great northern, seed 3.500000 1.000 1.000 4F6895

0603036000 6C Bean, kidney, seed 3.500000 1.000 1.000 4F6895

0603038000 6C Bean, lima, seed 3.500000 1.000 1.000 4F6895

0603039000 6C Bean, mung, seed 3.500000 1.000 1.000 4F6895
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 19 of 23

0603040000 6C Bean, navy, seed 3.500000 1.000 1.000 4F6895

0603041000 6C Bean, pink, seed 3.500000 1.000 1.000 4F6895

0603042000 6C Bean, pinto, seed 3.500000 1.000 1.000 4F6895

0603098000 6C Chickpea, seed 3.500000 1.000 1.000 4F6895

0603098001 6C Chickpea, seed-babyfood 3.500000 1.000 1.000 4F6895

0603099000 6C Chickpea, flour 3.500000 1.000 1.000 4F6895

0603182000 6C Guar, seed 3.500000 1.000 1.000 4F6895

0603182001 6C Guar, seed-babyfood 3.500000 1.000 1.000 4F6895

0603203000 6C Lentil, seed 3.500000 1.000 1.000 4F6895

0603256000 6C Pea, dry 3.500000 1.000 1.000 4F6895

0603256001 6C Pea, dry-babyfood 3.500000 1.000 1.000 4F6895

0603258000 6C Pea, pigeon, seed 3.500000 1.000 1.000 4F6895

0603348000 6C Soybean, flour 10.000000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 10.000000 1.000 1.000 

0801374000 8A Tomatillo 1.000000 1.000 1.000 

0801375000 8A Tomato 1.000000 1.000 1.000 

0801375001 8A Tomato-babyfood 1.000000 1.000 1.000 

0801376000 8A Tomato, paste 1.000000 5.400 1.000 previo

 Full comment: previous tolerance expired 4/30/03

0801376001 8A Tomato, paste-babyfood 1.000000 5.400 1.000 previo

 Full comment: previous tolerance expired 4/30/03

0801377000 8A Tomato, puree 1.000000 3.300 1.000 previo

 Full comment: previous tolerance expired 4/30/03

0801377001 8A Tomato, puree-babyfood 1.000000 3.300 1.000 previo

 Full comment: previous tolerance expired 4/30/03

0801378000 8A Tomato, dried 1.000000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 1.000000 14.300 1.000 

0801379000 8A Tomato, juice 1.000000 1.500 1.000 

0801380000 8A Tomato, Tree 1.000000 1.000 1.000 

0802148000 8BC Eggplant 1.000000 1.000 1.000 

0802234000 8BC Okra 1.000000 1.000 1.000 

0802270000 8B Pepper, bell 1.000000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 1.000000 1.000 1.000 

0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 1.000000 1.000 1.000 

0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 1.000000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 

0901075000 9A Cantaloupe 2.000000 1.000 1.000 

0901187000 9A Honeydew melon 2.000000 1.000 1.000 

0901399000 9A Watermelon 2.000000 1.000 1.000 

0901400000 9A Watermelon, juice 2.000000 1.000 1.000 

0902021000 9B Balsam pear 0.500000 1.000 1.000 

0902088000 9B Chayote, fruit 0.500000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.500000 1.000 1.000 

0902135000 9B Cucumber 0.500000 1.000 1.000 

0902308000 9B Pumpkin 0.500000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 

0902356000 9B Squash, summer 0.500000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.500000 1.000 1.000 

0902357000 9B Squash, winter 0.500000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.500000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.200000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.200000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.200000 1.000 1.000 

1100009000 11 Apple, dried 0.200000 8.000 1.000 D42576

 Full comment: D425763

1100009001 11 Apple, dried-babyfood 0.200000 8.000 1.000 

1100010000 11 Apple, juice 0.200000 1.300 1.000 

1100010001 11 Apple, juice-babyfood 0.200000 1.300 1.000 

1100011000 11 Apple, sauce 0.200000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.200000 1.000 1.000 

1100129000 11 Crabapple 0.200000 1.000 1.000 

1100173500 11 Goji berry 1.000000 1.000 1.000 

1100210000 11 Loquat 0.200000 1.000 1.000 

1100266000 11 Pear 0.200000 1.000 1.000 D42576
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 20 of 23

 Full comment: D425763

1100266001 11 Pear-babyfood 0.200000 1.000 1.000 

1100267000 11 Pear, dried 0.200000 6.250 1.000 

1100268000 11 Pear, juice 0.200000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.200000 1.000 1.000 

1100310000 11 Quince 0.200000 1.000 1.000 

1201090000 12A Cherry 0.200000 1.000 1.000 D42576

 Full comment: D425763

1201090001 12A Cherry-babyfood 0.200000 1.000 1.000 

1201091000 12A Cherry, juice 0.200000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 0.200000 1.500 1.000 

1202012000 12B Apricot 0.200000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.200000 1.000 1.000 

1202013000 12B Apricot, dried 0.200000 6.000 1.000 

1202014000 12B Apricot, juice 0.200000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.200000 1.000 1.000 

1202230000 12B Nectarine 0.200000 1.000 1.000 

1202260000 12B Peach 0.200000 1.000 1.000 

1202260001 12B Peach-babyfood 0.200000 1.000 1.000 

1202261000 12B Peach, dried 0.200000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 0.200000 7.000 1.000 

1202262000 12B Peach, juice 0.200000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.200000 1.000 1.000 

1203285000 12C Plum 0.200000 1.000 1.000 D42576

 Full comment: D425763

1203285001 12C Plum-babyfood 0.200000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.200000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.200000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.200000 5.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 0.200000 5.000 1.000 

1203288000 12C Plum, prune, juice 0.200000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.200000 1.400 1.000 

1301055000 13A Blackberry 0.300000 1.000 1.000 

1301056000 13A Blackberry, juice 0.300000 1.000 1.000 

1301056001 13A Blackberry, juice-babyfood 0.300000 1.000 1.000 

1301058000 13A Boysenberry 0.300000 1.000 1.000 

1301208000 13A Loganberry 0.300000 1.000 1.000 

1301320000 13A Raspberry 0.300000 1.000 1.000 

1301320001 13A Raspberry-babyfood 0.300000 1.000 1.000 

1301321000 13A Raspberry, juice 0.300000 1.000 1.000 

1301321001 13A Raspberry, juice-babyfood 0.300000 1.000 1.000 

1302057000 13B Blueberry 0.200000 1.000 1.000 

1302057001 13B Blueberry-babyfood 0.200000 1.000 1.000 

1302136000 13B Currant 0.200000 1.000 1.000 

1302137000 13B Currant, dried 0.200000 1.000 1.000 

1302149000 13B Elderberry 0.200000 1.000 1.000 

1302174000 13B Gooseberry 0.200000 1.000 1.000 

1302191000 13B Huckleberry 0.200000 1.000 1.000 

1307130000 13G Cranberry 0.500000 1.000 1.000 

1307130001 13G Cranberry-babyfood 0.500000 1.000 1.000 

1307131000 13G Cranberry, dried 0.500000 1.000 1.000 

1307132000 13G Cranberry, juice 0.500000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 0.500000 1.100 1.000 

1307359000 13G Strawberry 3.000000 1.000 1.000 

1307359001 13G Strawberry-babyfood 3.000000 1.000 1.000 

1307360000 13G Strawberry, juice 3.000000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 3.000000 1.000 1.000 

1500120000 15 Corn, field, flour 0.200000 1.000 1.000 6F7117

1500120001 15 Corn, field, flour-babyfood 0.200000 1.000 1.000 6F7117

1500121000 15 Corn, field, meal 0.200000 1.000 1.000 6F7117

1500121001 15 Corn, field, meal-babyfood 0.200000 1.000 1.000 6F7117

1500122000 15 Corn, field, bran 0.200000 1.000 1.000 6F7117

1500123000 15 Corn, field, starch 0.200000 1.000 1.000 6F7117

1500123001 15 Corn, field, starch-babyfood 0.200000 1.000 1.000 6F7117

1500124000 15 Corn, field, syrup 0.200000 1.500 1.000 6F7117

1500124001 15 Corn, field, syrup-babyfood 0.200000 1.500 1.000 6F7117
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 21 of 23

1500125000 15 Corn, field, oil 0.200000 1.000 1.000 6F7117

1500125001 15 Corn, field, oil-babyfood 0.200000 1.000 1.000 6F7117

1901028000 19A Basil, fresh leaves 12.000000 1.000 1.000 4E6836

1901028001 19A Basil, fresh leaves-babyfood 12.000000 1.000 1.000 4E6836

1901029000 19A Basil, dried leaves 12.000000 1.000 1.000 4E6836

1901029001 19A Basil, dried leaves-babyfood 12.000000 1.000 1.000 4E6836

1901102500 19A Chive, dried leaves 12.000000 1.000 1.000 

1901118000 19A Cilantro, leaves 12.000000 1.000 1.000 4E6936

1901118001 19A Cilantro, leaves-babyfood 12.000000 1.000 1.000 4E6936

1901144000 19A Dillweed 12.000000 1.000 1.000 4E6836

1901184000 19A Herbs, other 12.000000 1.000 1.000 4E6836

1901184001 19A Herbs, other-babyfood 12.000000 1.000 1.000 4E6836

1901202000 19A Lemongrass 12.000000 1.000 1.000 4E6836

1901220000 19A Marjoram 12.000000 1.000 1.000 4E6836

1901220001 19A Marjoram-babyfood 12.000000 1.000 1.000 4E6836

1901249000 19A Parsley, dried leaves 12.000000 1.000 1.000 4E6836

1901249001 19A Parsley, dried leaves-babyfood 12.000000 1.000 1.000 4E6836

1901334000 19A Savory 12.000000 1.000 1.000 4E6836

2001163000 20A Flax seed, oil 0.600000 1.000 1.000 

2001319000 20A Rapeseed, oil 0.500000 1.000 1.000 

2001319001 20A Rapeseed, oil-babyfood 0.500000 1.000 1.000 D42576

 Full comment: D425763

2001336000 20A Sesame, seed 0.500000 1.000 1.000 

2001336001 20A Sesame, seed-babyfood 0.500000 1.000 1.000 

2001337000 20A Sesame, oil 0.500000 1.400 1.000 

2001337001 20A Sesame, oil-babyfood 0.500000 1.400 1.000 

2002330000 20B Safflower, oil 5.000000 1.000 1.000 D42576

 Full comment: D425763

2002330001 20B Safflower, oil-babyfood 5.000000 1.000 1.000 

2002364000 20B Sunflower, seed 5.000000 1.000 1.000 

2002365000 20B Sunflower, oil 5.000000 1.000 1.000 

2002365001 20B Sunflower, oil-babyfood 5.000000 1.000 1.000 

2003114001 20C Coconut, oil-babyfood 1.000000 1.000 1.000 D42576

 Full comment: D425763

2003128000 20C Cottonseed, oil 1.000000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 1.000000 1.000 1.000 

3100044000 31 Beef, meat 0.200000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.200000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.200000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.200000 1.000 1.000 

3100047000 31 Beef, fat 0.200000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.200000 1.000 1.000 

3100048000 31 Beef, kidney 0.200000 1.000 1.000 

3100049000 31 Beef, liver 0.200000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.200000 1.000 1.000 

3200169000 32 Goat, meat 0.200000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000 

3200171000 32 Goat, fat 0.200000 1.000 1.000 

3200172000 32 Goat, kidney 0.200000 1.000 1.000 

3200173000 32 Goat, liver 0.200000 1.000 1.000 

3300189000 33 Horse, meat 0.200000 1.000 1.000 

3400290000 34 Pork, meat 0.200000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.200000 1.000 1.000 

3400291000 34 Pork, skin 0.200000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.200000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.200000 1.000 1.000 

3400293000 34 Pork, fat 0.200000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.200000 1.000 1.000 

3400294000 34 Pork, kidney 0.200000 1.000 1.000 

3400295000 34 Pork, liver 0.200000 1.000 1.000 

3500339000 35 Sheep, meat 0.200000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.200000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 

3500341000 35 Sheep, fat 0.200000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.200000 1.000 1.000 
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 22 of 23

3500342000 35 Sheep, kidney 0.200000 1.000 1.000 

3500343000 35 Sheep, liver 0.200000 1.000 1.000 

3600222000 36 Milk, fat 0.050000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.050000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.050000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 

3600224000 36 Milk, water 0.050000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.050000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 

4000093000 40 Chicken, meat 0.200000 1.000 1.000 

4000093001 40 Chicken, meat-babyfood 0.200000 1.000 1.000 

4000094000 40 Chicken, liver 0.200000 1.000 1.000 

4000095000 40 Chicken, meat byproducts 0.200000 1.000 1.000 

4000095001 40 Chicken, meat byproducts-babyfoo 0.200000 1.000 1.000 

4000096000 40 Chicken, fat 0.200000 1.000 1.000 

4000096001 40 Chicken, fat-babyfood 0.200000 1.000 1.000 

4000097000 40 Chicken, skin 0.200000 1.000 1.000 

4000097001 40 Chicken, skin-babyfood 0.200000 1.000 1.000 

5000382000 50 Turkey, meat 0.200000 1.000 1.000 

5000382001 50 Turkey, meat-babyfood 0.200000 1.000 1.000 

5000383000 50 Turkey, liver 0.200000 1.000 1.000 

5000383001 50 Turkey, liver-babyfood 0.200000 1.000 1.000 

5000384000 50 Turkey, meat byproducts 0.200000 1.000 1.000 

5000384001 50 Turkey, meat byproducts-babyfood 0.200000 1.000 1.000 

5000385000 50 Turkey, fat 0.200000 1.000 1.000 

5000385001 50 Turkey, fat-babyfood 0.200000 1.000 1.000 

5000386000 50 Turkey, skin 0.200000 1.000 1.000 

5000386001 50 Turkey, skin-babyfood 0.200000 1.000 1.000 

6000301000 60 Poultry, other, meat 0.200000 1.000 1.000 

6000302000 60 Poultry, other, liver 0.200000 1.000 1.000 

6000303000 60 Poultry, other, meat byproducts 0.200000 1.000 1.000 

6000304000 60 Poultry, other, fat 0.200000 1.000 1.000 

6000305000 60 Poultry, other, skin 0.200000 1.000 1.000 

7000145000 70 Egg, whole 0.200000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.200000 1.000 1.000 

7000146000 70 Egg, white 0.200000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.200000 1.000 1.000 

7000147000 70 Egg, yolk 0.200000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.200000 1.000 1.000 

8601000000 86A Water, direct, all sources 1.150000 1.000 1.000 

8602000000 86B Water, indirect, all sources 1.150000 1.000 1.000 

9500016000 O Artichoke, globe 1.200000 1.000 1.000 

9500019000 O Asparagus 1.700000 1.000 1.000 5E6977

9500188000 O Hop 0.500000 1.000 1.000 5E6977

9500263000 O Peanut 3.000000 1.000 1.000 

9500264000 O Peanut, butter 3.000000 1.890 1.000 Harmon

 Full comment: Harmonize with Codex

9500265000 O Peanut, oil 3.000000 1.000 1.000 

9500275000 O Peppermint 5.000000 1.000 1.000 

9500276000 O Peppermint, oil 5.000000 1.000 1.000 

9500352000 O Spearmint 5.000000 1.000 1.000 

9500353000 O Spearmint, oil 5.000000 1.000 1.000 
Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 23 of 23

Attachment 4: Chronic Food and Water Result File

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for CLETHODIM NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\MNEGUSSI\My Documents\DEEM Version 

3.16\Clethodim\New folder\ChronicClethodim2016.R08

 Adjustment factor #2 NOT used.

Analysis Date 01-19-2016/11:44:19 Residue file dated: 01-19-2016/11:42:54

Reference dose (RfD, Chronic) = .3 mg/kg bw/day

COMMENT 1: New Chronic Reference Dose; New uses apple, pear, cherry, plum and crop 

group expansion;

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.037592 12.5%

Hispanic 0.037148 12.4%

Non-Hisp-White 0.038086 12.7%

Non-Hisp-Black 0.032509 10.8%

Non-Hisp-Other 0.044262 14.8%

Nursing Infants 0.035322 11.8%

Non-Nursing Infants 0.114860 38.3%

Female 13+ PREG 0.034795 11.6%

Children 1-6 0.065046 21.7%

Children 7-12 0.038039 12.7%

Male 13-19 0.028061 9.4%

Female 13-19/NP 0.029350 9.8%

Male 20+ 0.033038 11.0%

Female 20+/NP 0.035985 12.0%

Seniors 55+ 0.033746 11.2%

All Infants 0.090304 30.1%

Female 13-50 0.034534 11.5%

Children 1-2 0.074277 24.8%

Children 3-5 0.061470 20.5%

Children 6-12 0.040639 13.5%

Youth 13-19 0.028696 9.6%

Adults 20-49 0.034796 11.6%

Adults 50-99 0.034303 11.4%

Female 13-49 0.034543 11.5%

-------------------------------------------------------------------------------