UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549



FORM 10-K/A
(Amendment No. 1)



(Mark
One)

|☒ | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For
the fiscal year ended December 31, 2014

or



|☐ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------





For
the transition period from __________________ to
__________________________



Commission
file number: 333-185891



ENUMERAL BIOMEDICAL HOLDINGS, INC.

(Exact
name of registrant as specified in its charter)



|Delaware                                                       | 99-0376434                          
|-------------------------------------------------------------- | ------------------------------------
|(State or other jurisdiction of incorporation or organization) | (I.R.S. Employer Identification No.)





|200 CambridgePark Drive, Suite 2000
        Cambridge, Massachusetts | 02140         
|-------------------------------------------------------------------- | --------------
|(Address of principal executive offices)                             | (Zip Code)    
|Registrant’s telephone number, including area code:                  | (617) 945-9146



Securities
registered pursuant to Section 12(b) of the Act:



|Title of each class | Name of each exchange on which registered
|------------------- | -----------------------------------------
|None                | Not applicable                           



Securities
registered pursuant to Section 12(g) of the Act:



Common
Stock, $0.001 Par Value Per Share(Title of class)



Indicate by check mark if the registrant is
a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. ☐
Yes ☒ No



Indicate by check mark if the registrant is
not required to file reports pursuant to Section 13 or Section 15(d) of the Act. ☐
Yes ☒ No















Indicate by check mark whether the registrant
(1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding
12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days. ☐Yes ☐
No



Indicate by check mark whether the registrant
has submitted electronically and posted on its corporate Website, if any, every Interactive Data File required to be submitted
and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter
period that the registrant was required to submit and post such files). ☐Yes
☒ No



Indicate by check mark if disclosure of delinquent
filers pursuant to Item 405 of Regulation S-K (§229.405 of this chapter) is not contained herein, and will not be contained,
to the best of the registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part
III of this Form 10-K or any amendment to this Form 10-K. ☐
Yes ☒ No



Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company:



|Large accelerated filer | ☐ | Accelerated filer         | ☐
|----------------------- | - | ------------------------- | -
|Non-accelerated filer   | ☐ | Smaller reporting company | ☒



Indicate by check mark whether the registrant
is a shell company (as defined in Rule 12b-2 of the Exchange Act) ☐
Yes ☒ No



State the aggregate market value of the voting
and non-voting common equity held by non-affiliates computed by reference to the price at which the common equity was last sold,
or the average bid and asked price of such common equity, as of the last business day of the registrant’s most recently completed
second fiscal quarter. No market value has been computed based upon the fact that no active trading market had been established
as of June 30, 2014.



Indicate the number of shares outstanding
of each of the registrant’s classes of common stock, as of the latest practicable date: 51,607,665 shares of common stock
are issued and outstanding as of April 24, 2015.



DOCUMENTS INCORPORATED BY REFERENCE



None.















TABLE OF
CONTENTS







|         |  | PART
    III                                                                                        |  | Page | 
|-------- |  | --------------------------------------------------------------------------------------------------- |  | ---- | 
|         |  |                                                                                                     |  |      | 
|ITEM 10. |  | DIRECTORS,
    EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE.                                         |  | 2    | 
|         |  |                                                                                                     |  |      | 
|ITEM 11. |  | EXECUTIVE
    COMPENSATION.                                                                         |  | 12   | 
|         |  |                                                                                                     |  |      | 
|ITEM 12. |  | SECURITY OWNERSHIP OF
    CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS. |  | 22   | 
|         |  |                                                                                                     |  |      | 
|ITEM 13. |  | CERTAIN
RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE.                          |  | 25   | 
|         |  |                                                                                                     |  |      | 
|ITEM 14. |  | PRINCIPAL
    ACCOUNTING FEES AND SERVICES.                                                         |  | 27   | 
|         |  |                                                                                                     |  |      | 
|         |  | PART
    IV                                                                                         |  |      | 
|         |  |                                                                                                     |  |      | 
|ITEM 15. |  | EXHIBITS,
    FINANCIAL STATEMENT SCHEDULES.                                                        |  | 28   | 





















EXPLANATORY NOTE



Enumeral Biomedical Holdings, Inc. (the “Company”)
filed its Form 10-K for the year ended December 31, 2014 (the “2014 Form 10-K”) with the U.S. Securities and Exchange
Commission (the “SEC”) on March 19, 2015. Pursuant to General Instruction G(3) to Form 10-K, the Company incorporated
by reference the information required by Part III of Form 10-K from its definitive proxy statement for the 2015 Annual Meeting
of Stockholders (the “2015 Proxy Statement”) that the Company expected to file with the SEC no later than 120 days
after the end of the fiscal year covered by the 2014 Form 10-K. Because a definitive 2015 Proxy Statement will not be filed with
the SEC before such date, the Company is filing this Amendment No. 1 to the 2014 Form 10-K (the “Form 10-K/A”) to provide
the additional information required by Part III of Form 10-K.



This Form 10-K/A does not change the previously
reported financial statements or any of the other disclosures contained in Parts I, II or IV of the original 2014 Form 10-K, other
than to update information provided in the Exhibit List under Part IV, Item 15(b) of the original 2014 Form 10-K. The complete
text of Items 10 through 14 of Part III and Item 15 of Part IV, each as amended and restated, is included in this Form 10-K/A.
Except for the foregoing amended and restated information, this Form 10-K/A does not amend, update or change any other information
presented in the original 2014 Form 10-K.



In addition, as required by Rule 12b-15 of
the Securities Exchange Act of 1934, as amended (the “Exchange Act”), this Form 10-K/A contains new certifications
by the Company’s principal executive officer and principal financial officer, which are being filed as Exhibits to this Form
10-K/A.

















PART
III







| | ITEM 10. | DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE.
| | -------- | -------------------------------------------------------



Directors and Executive Officers



Below are the names of and certain information regarding the
Company’s current executive officers and directors as of April 27, 2015:



|Name                          |  | Age |  | Position                                                          |  | Date Named to Board of Directors/as Executive Officer |  | Director Class (if applicable)
|----------------------------- |  | --- |  | ----------------------------------------------------------------- |  | ----------------------------------------------------- |  | ------------------------------
|John J. Rydzewski             |  | 62  |  | Chairman of the Board                                             |  | July 31, 2014                                         |  | I                             
|Arthur H. Tinkelenberg, Ph.D. |  | 48  |  | President, Chief Executive Officer and Director                   |  | July 31, 2014                                         |  | I                             
|Anhco Nguyen, Ph.D.           |  | 42  |  | Vice President of Research and Development                        |  | July 31, 2014                                         |  | -                             
|Derek Brand                   |  | 38  |  | Vice President of Business Development                            |  | July 31, 2014                                         |  | -                             
|Kevin G. Sarney               |  | 50  |  | Vice President of Finance, Chief Accounting Officer and Treasurer |  | July 31, 2014                                         |  | -                             
|Barry Buckland                |  | 67  |  | Director                                                          |  | July 31, 2014                                         |  | II                            
|Allan Rothstein               |  | 57  |  | Director                                                          |  | July 31, 2014                                         |  | II                            
|Paul J. Sekhri                |  | 56  |  | Director                                                          |  | December 16, 2014                                     |  | III                           
|Robert L. Van Nostrand        |  | 58  |  | Director                                                          |  | December 1, 2014                                      |  | III                           
|Daniel B. Wolfe               |  | 38  |  | Director                                                          |  | July 31, 2014                                         |  | III                           



Our board of directors is divided into three classes, designated
Class I, Class II and Class III. Each class consists, as nearly as may be possible, of one-third of the total number of directors
constituting the entire board of directors. Class I directors were elected initially for a one-year term which will expire at the
2015 Annual Meeting of Stockholders, Class II directors were elected initially for a two-year term which will expire in 2016 and
Class III directors were elected initially for a three-year term which will expire in 2017. At each succeeding annual meeting of
stockholders beginning with this annual meeting of stockholders, successors to the class of directors whose term expires at that
annual meeting will be elected for a three-year term. If the number of directors is changed, any increase or decrease will be apportioned
among the classes so as to maintain the number of directors in each class as nearly equal as possible, and any additional director
of any class will hold office for a term that will coincide with the remaining term of that class, but in no case will a decrease
in the number of directors shorten the term of any incumbent director.





2







A majority of the authorized number of directors constitutes
a quorum of the Board of Directors for the transaction of business. The directors must be present at the meeting to constitute
a quorum. However, any action required or permitted to be taken by the Board of Directors may be taken without a meeting if all
members of the Board of Directors individually or collectively consent in writing to the action.



Executive officers are appointed by the Board of Directors and
serve at its pleasure.



The principal occupation and business experience during the
past five years for our executive officers and directors is as follows:



John J. Rydzewski – Executive Chairman of the Board
of Directors and Co-Founder



Mr. Rydzewski has served as the Executive Chairman of our board
of directors since the Merger (as defined below), and prior thereto served as a director of Enumeral Biomedical Corp. (“Enumeral”)
since September 2010 and as Executive Chairman of Enumeral’s board since October 2011. From July 2006 to September 2011,
Mr. Rydzewski was managing director of Christofferson, Robb & Co., an investment firm where he monetized life-sciences
intellectual property covering large and small molecule therapeutics. His banking career included partnership responsibilities
at Benedetto, Gartland & Co., an investment bank serving corporate and institutional clients, and officer positions in the
merchant banking and healthcare specialty finance units of Kidder, Peabody & Co. Incorporated and Dean Witter Reynolds Inc.
Prior to banking, he was a manager in the Bankruptcy Services Group of Price Waterhouse & Co. and he also previously held positions
in industry. He has previously served as a director of publicly traded and privately held healthcare companies and he currently
serves as a director of Fidelis Care, Inc., a provider of health insurance coverage. Mr. Rydzewski is also Co-Chairman
of the Board of Advisors of the RAND Corporation’s health policy research unit. He received an M.B.A. and a B.S. in Economics
with Honors from The Wharton School of the University of Pennsylvania. The board of directors has concluded that Mr. Rydzewski
should serve on our board because of his significant life sciences industry experience as an institutional investor, investment
banker and corporate director.



Arthur H. Tinkelenberg, Ph.D. – President, Chief Executive
Officer, Director and Co-Founder



Dr. Tinkelenberg has served as our President and Chief Executive
Officer and a director of the Company since the Merger, and prior thereto was President, Chief Executive Officer and a director
of Enumeral since September 2010. From 2003 through 2009, Dr. Tinkelenberg was a partner in Ascent Biomedical Ventures, a life
sciences venture capital firm focused on early stage biomedical technologies, where he was responsible for originating and managing
numerous biotechnology and medical device company investments. From January 2001 through July 2002, he served in the healthcare
corporate finance and mergers and acquisitions group of Robertson Stephens. Prior to industry, Dr. Tinkelenberg conducted research
in lipid metabolism, genomics, biochemistry, and cell biology as a Research Scientist at Columbia University from 1996 through
2000. He is a published author and inventor on a number of patents from projects initiated by him during his tenure in academic
research. He received his Ph.D. in molecular genetics from The Rockefeller University and his B.A. in Biology from Grinnell College.
The board of directors has concluded that Dr. Tinkelenberg should serve on our board because of his significant experience in the
life sciences industry as an investment banker and venture capitalist, as well as his previous life sciences academic research.



Anhco Nguyen, Ph.D. - Vice President of Research and Development



Dr. Nguyen has served as our Vice President of Research
and Development since the Merger, and prior thereto held positions of increasing responsibility since joining Enumeral in
January 2012. Dr. Nguyen leads our research and development team and is responsible for both our proprietary discovery and
corporate partnership programs. He participates with our business development team in structuring new research collaboration
initiatives. He brings to this role significant industry experience in the development of therapeutic antibodies for
treatment of cancer and multiple sclerosis, including as staff scientist at Forma Therapeutics from June 2009 to January
2012, and as staff scientist at Genzyme Corp. from June 2006 to May 2009. He completed postdoctoral training at MIT’s
Cancer Center and was the recipient of a Presidential Postdoctoral Fellowship, which he completed at the Novartis Institute
for Biomedical Research. He received his Ph.D. Immunology from Washington University and his A.B. in Biology from Harvard
College. He has co-authored numerous articles in the
fields of cancer and immunology.





3







Derek Brand - Vice President of Business Development



Mr. Brand has served as our Vice President of Business Development
since the Merger, and prior thereto held positions of increasing responsibility since joining Enumeral in May 2011. Mr. Brand is
responsible for initiating, negotiating and executing business collaborations with biopharmaceutical companies and other potential
partners. He has broad-based experience creating and implementing
growth strategies for biomedical startup companies, having served in both business roles and scientific capacities. From October
2007 to May 2011, Mr. Brand served as Director of Business Development at the New York Academy of Sciences, a scientific organization
with over 20,000 members throughout the world. From July 2005 to October 2007, Mr. Brand served as Global Product Manager for the
GE Sensing division of General Electric, a multinational conglomerate. Prior in his career, Mr. Brand served in business development
and research roles for several life sciences and medical device companies, and as an equity analyst covering emerging biotech and
pharmaceutical companies. He received his MBA from Babson College and his B.A. in Biology from Hamilton College.



Kevin G. Sarney – Vice President of Finance, Chief
Accounting Officer and Treasurer



Kevin G. Sarney has served as our Vice President of Finance,
Chief Accounting Officer and Treasurer since the Merger. From September 2013 to July 2014, Mr. Sarney served as Vice President,
Finance and Administration for Avaxia Biologics, Inc., a privately-held clinical-stage biopharmaceutical company developing gut-targeted
therapeutics. Prior to joining Avaxia, Mr. Sarney provided financial consulting services to various life sciences companies from
May 2009 to August 2013, including at Helicos BioSciences Corporation, a publicly traded medical device sequencing company, from
December 2009 to May 2010 and at Archemix Corp., a privately held aptamer therapeutics company, from June 2010 to February 2012.
From March 2005 to April 2009, Mr. Sarney held positions of increasing responsibility at Nitromed, Inc., a publicly traded cardiovascular-focused
pharmaceutical company, culminating as Corporate Controller and Principal Accounting Officer. Mr. Sarney earned a B.S. in business
management from the University of Hartford, an M.B.A. from Boston University, and an M.A. in accounting from Suffolk University.
Mr. Sarney is a certified public accountant in the Commonwealth of Massachusetts.



Barry Buckland, Ph.D. – Director, Co-Founder and Chairman
of the Scientific Advisory Board



Dr. Buckland has been a member of our board of directors
since the Merger and prior thereto served as member of the board of directors of Enumeral since December 2009. Dr.
Buckland’s career in the pharmaceutical industry includes his leadership of Merck’s bioprocess Research and
Development Group, which saw the market launch of major biological products, including Gardasil, Rotateq, and Zostavax. Since
May 2009, Dr. Buckland has been the Chief Executive Officer of BiologicB LLC, a consulting firm working with biotechnology
and vaccine products. He is the recipient of numerous awards, among them the Donald Medal, UK Institute of Chemical
Engineering in 2002, Prix Galien award as a member of the team that received the Vaccine Award for Gardasil in 2007, the
Marvin Johnson award by ACS for lifetime contribution to Biotechnology in 2008, and the PhRMA Discoverer of the Year for
development of the Merck HPV vaccine (along with Eliav Barr and Kathrin Jansen) in 2009. He has chaired multiple
International Conferences related to Bioprocess Research and Development and Vaccine Technology and is an author on over 70
papers. He has been a Visiting Professor at University College London since 1995. Dr. Buckland earned his Ph.D. in
Biochemical Engineering at University College London in 1974. The board of directors has concluded that Dr. Buckland should
serve on our board because of his significant experience in the pharmaceutical and biotechnology industries.







4







Allan P. Rothstein – Director



Mr. Rothstein has been a member of our board of directors since
the Merger, and prior thereto served as member of the board of directors of Enumeral since September 2013. December 2011, Mr. Rothstein
has been a principal of Healthcare Recovery Services LLC, servicing financial aspects and enhancing revenue cycles of hospitals
and other healthcare service enterprises. Mr. Rothstein has owned and managed Hedge Capital Partners LLC, an investment vehicle
for venture capital, portfolio management and asset management, since April 2004, and he is also the owner of Shizoom LLC, a business
funding company formed in March 2013. Mr. Rothstein was head of trading at Centurion Partners from September 2010 to August 2011.
From 2002 through 2007, Mr. Rothstein was founder and Chairman of NanoDynamics Inc. He has served as a member of the National Nanotechnology
Business Alliance and the New York Nanotechnology Business Alliance advisory boards and the Dean’s Council of the Graduate
School of SUNY Stonybrook. Mr. Rothstein has over 30 years’ experience in the financial industry, having started his career
at Shearson Loeb Rhoades where he handled arbitrage lines for domestic and international customers. In 1982, he became a member
of the New York Futures Exchange. In 1990 he joined Fahnestock & Company (presently, Oppenheimer & Company) as a Nasdaq
market maker. In his role as Senior Vice President and co-head of Nasdaq Trading, Mr. Rothstein was responsible for trading in
over 500 markets, oversight of all Nasdaq market making and trading systems construction and integration. Mr. Rothstein graduated
as a Benjamin Franklin Scholar from The University of Pennsylvania, magna cum laude, in 1980. The board of directors has
concluded that Mr. Rothstein should serve on our board because of his significant experience as an investor in, and advisor to,
emerging technology companies.



Paul J. Sekhri – Director



Mr. Sekhri has been a member of the Board of Directors of
the Company since December 2014. Since February 2015, Mr. Sekhri has served as President and Chief Executive Officer and a
member of the board of directors of Lycera Corp., a biopharmaceutical company that is developing medicines to treat cancer
and autoimmune disease. From April 2014 to February 2015, Mr. Sekhri was Senior Vice President, Integrated Care at Sanofi
S.A., a multinational pharmaceutical company, where he led the company’s efforts to create innovative solutions and
business models to meet patient needs. Prior to Sanofi, Mr. Sekhri served from June 2013 to March 2014 as Group Executive
Vice President, Global Business Development and Chief Strategy Officer for Teva Pharmaceutical Industries, Ltd., a
multinational pharmaceutical company. From January 2009 to May 2014, Mr. Sekhri served as Operating Partner and Head of the
Biotechnology Operating Group at TPG Biotech, the life sciences venture capital arm of TPG Capital. From 2004 to 2009, Mr.
Sekhri was Founder, President, and Chief Executive Officer of Cerimon Pharmaceuticals, Inc. Prior to founding Cerimon, Mr.
Sekhri was President and Chief Business Officer of ARIAD Pharmaceuticals, Inc. from 2003 to 2004. From 2002 to 2003, Mr.
Sekhri was a partner at New Leaf Ventures, where he focused on healthcare investments. From 1999 to 2003, Mr. Sekhri held
various positions at Novartis Pharma AG, including Senior Vice President and Head of Global Search and Evaluation, Business
Development and Licensing. Mr. Sekhri serves on the board of directors of Veeva Systems Inc., a publicly-held cloud-based
software company focused on the life sciences industry. Mr. Sekhri is also a member of the board of directors of Ascendancy
Healthcare Inc., a privately held company focused on the development and registration of pharmaceutical products in China and
other high-growth Asian markets. Mr. Sekhri serves on the board of directors of the non-profit Cancer Research Institute, the
BioExec Institute, Inc., the Industry Advisory Board of the Michael J. Fox Foundation, the TB Alliance, the Tectonic Theatre
Project, and Young Concert Artists, Inc. Mr. Sekhri is a member of the Patrons Council of Carnegie Hall, where he served as a
member of the Board of Trustees from 2010 to 2012. Mr. Sekhri holds a B.S. in Zoology from the University of Maryland.
The board of directors has concluded that Mr. Sekhri should serve on our board because of his significant experience as a
senior executive and director in the life sciences industry.





5









Robert L. Van Nostrand – Director



Mr. Van Nostrand has been a member of the Board of Directors
of the Company since December 2014. Since 2010, Mr. Van Nostrand has served as an advisor and board member to several biotechnology
companies. From January 2010 to July 2010, Mr. Van Nostrand was Executive Vice President and Chief Financial Officer of Aureon
Laboratories, Inc., a pathology life sciences company. Prior to joining Aureon Laboratories, Mr. Van Nostrand served
as Executive Vice President and Chief Financial Officer of AGI Dermatics, Inc., a private biotechnology company, from July 2007
to September 2008, at which time the company was acquired. From May 2005 to July 2007, Mr. Van Nostrand served as the Senior
Vice President and Chief Compliance Officer of OSI Pharmaceuticals, Inc. a biotechnology company, where he previously served as
Vice President and Chief Financial Officer from December 1996 through May 2005, and as Vice President, Finance and Administration
prior to that. He also served as OSI’s Treasurer from March 1992 to May 2005, and as Secretary from March 1995 to January
2004. Mr. Van Nostrand joined OSI as Controller and Chief Accounting Officer in September 1986. Prior to joining OSI, Mr. Van
Nostrand served in a managerial position with the accounting firm of Touche Ross & Co. (now Deloitte). Mr. Van Nostrand
serves on the board of directors Achillion Pharmaceuticals, Inc., a publicly-held biotechnology company, where he is chairman of
the audit committee and a member of the compensation committee. Mr. Van Nostrand also serves on the board of directors and is chairman
of the audit committee of Intra-Cellular Therapies, Inc. and Metabolix, Inc., both publicly-held biotechnology companies. In addition,
Mr. Van Nostrand is chairman of the board of directors at Metabolix. Mr. Van Nostrand is on the board of the Biomedical Research
Alliance of New York, a private company providing clinical trial services, as well as the Board of the New York Biotechnology Association,
where he previously served as chairman. In addition, he is on the Foundation Board of Farmingdale University. Mr. Van Nostrand
holds a B.S. in Accounting from Long Island University, New York, and he is a Certified Public Accountant.The board of
directors has concluded that Mr. Van Nostrand should serve on our board because of his significant experience as a senior executive
and director in the life sciences industry.



Daniel B. Wolfe, Ph.D. – Director



Dr. Wolfe has been a member of our board of directors
since the Merger, and prior thereto served as member of the board of directors of Enumeral since 2009. Since January 2009,
Dr. Wolfe has served as President and Chief Operating Officer of Harris & Harris Group, Inc., a publicly traded venture
capital firm that invests in transformative companies enabled by disruptive science. Dr. Wolfe has also served as a Managing
Director of Harris & Harris Group, Inc. since January 2008. Previously, he served as Harris & Harris Group,
Inc.’s Chief Financial Officer from January 2008 to December 2012 and as Treasurer from May 2008 to December 2012. Dr.
Wolfe has served as President and Chief Operating Officer of H&H Ventures Management, Inc., a wholly-owned subsidiary of
Harris & Harris Group, Inc., since January 2009. Dr. Wolf previously served H&H Ventures Management as Chief
Financial Officer from January 2009 to December 2012, and as a director from October 2008 to May 2012. At the request of
Harris & Harris Group, Inc., Dr. Wolfe served as Chief Executive Officer of Evolved Nanomaterial Sciences from July 1,
2008 to September 28, 2009. Evolved Nanomaterial Sciences filed for bankruptcy protection under Chapter 7 of the U.S.
Bankruptcy Code on September 30, 2009. Dr. Wolfe also serves on the boards of SiOnyx, Inc., SynGlyco, Inc., and Ultora, Inc.
He completed his Ph.D. and A.M. in Chemistry at Harvard University, and graduated from Rice University with a B.A. in
Chemistry. The board of directors has concluded that Dr. Wolfe should serve on our board because of his significant
experience in capital markets and previous scientific background.





6







Director Relationships and Arrangements



Except for Messrs. Rydzewski, Sekhri and Van Nostrand, none
of our current directors or executive officers have served as a director of another public company within the past five years.



On July 31, 2014, our wholly owned subsidiary,
Enumeral Acquisition Corp. (“Acquisition Sub”) merged (the “Merger”) with and into Enumeral. Enumeral was
the surviving corporation in the Merger and became our wholly owned subsidiary. All of the outstanding shares of Enumeral stock
were converted into shares of our common stock. Also on July 31, 2014, we closed a private placement offering (the “PPO”)
of 21,549,510 Units of our securities, at a purchase price of $1.00 per unit, each unit consisting of one share of our common stock
and a warrant to purchase one share of common stock at an exercise price of $2.00 per share. In connection with the transactions
pursuant to the Merger, certain stockholders of the Company (holding approximately 70% of the common stock), including all of the
investors in the PPO, all of the pre-Merger stockholders of the Company and certain of the Enumeral stockholders (including all
of its officers directors and principal stockholders) entered into a voting agreement in which they have agreed to vote their Company
stock to maintain the composition of the Company’s board of directors (the “Voting Agreement”). The Voting Agreement
will terminate on July 31, 2016.



To our knowledge, there are no arrangements or understandings
between any director, director nominee or executive officer and any other person pursuant to which any person was selected as a
director, director nominee or executive officer, other than the Voting Agreement. There are no family relationships between any
of our directors, director nominees or executive officers. To our knowledge, there have been no material legal proceedings as described
in Item 401(f) of Regulation S-K during the last ten years that are material to an evaluation of the ability or integrity of any
of our directors, director nominees or executive officers. In addition, to our knowledge, there are no pending legal proceedings
to which any of the directors or executive officers is a party adverse to or has a material interest that is adverse to the Company
or Enumeral.



Board of Directors and Corporate Governance



While we are currently
quoted on the over-the-counter market, we have adopted the corporate governance standards of a listed company on the Nasdaq Stock
Market, or Nasdaq. These standards require that a majority of the members of our board of directors be “independent,”
as Nasdaq defines that term, and that our board make an affirmative determination as to the independence of each director. Consistent
with these rules, our board of directors undertook its annual review of director independence in February 2015. During the review,
our board considered relationships and transactions during 2014 and during the past three fiscal years between each director or
any member of his or her immediate family, on the one hand, and the Company and its subsidiaries and affiliates, on the other hand.
The purpose of this review was to determine whether any such relationships or transactions were inconsistent with a determination
that the director is independent. Based on this review, our board of directors determined that Drs. Buckland and Wolfe and Messrs.
Sekhri and Van Nostrand are independent under the criteria established by Nasdaq and by our board of directors.



Our board of
directors held 5 meetings during 2014, and each incumbent director standing for election attended all of the meetings of the
board and the meetings of those committees on which each incumbent director served, in each case during the period that such
person was a director. The permanentcommittees established by our board of directors are the audit committee, the
compensation committee, and the nominating and governance committee, descriptions of which are set forth in more detail
below.







7







Each member of our board
of directors is expected to participate, either in person or via teleconference, in meetings of the board and meetings of committees
of which each director is a member, and to spend the time necessary to properly discharge such director’s respective duties
and responsibilities. Although we do not have a written policy regarding directors’ attendance at annual meetings of stockholders,
all directors are encouraged to attend. As we had no operations prior to the Merger, we did not have an annual meeting of stockholders
in 2014.



Board Leadership Structure



Our board of directors is currently chaired by Mr. Rydzewski.
The Board Chairman has authority, among other things, to call and preside over board of directors meetings, to set meeting agendas
and to determine materials to be distributed to the board. We believe that having
a Board Chairman separate from the chief executive officer can enhance the effectiveness of the board of directors as a whole.
In addition, our board believes it should be able to freely select the Board Chairman based on criteria that it deems to be in
the Company’s best interests and the interests of our stockholders, and therefore one person may, in the future, serve as
both our Chief Executive Officer and Board Chairman.



The board has designated
Mr. Van Nostrand as the lead independent director. We believe that the position of lead independent director reinforces the independence
of the board in its oversight of the Company's business and affairs. The lead independent director, among his other duties and
responsibilities, serves as chairman at sessions of the independent and non-employee directors, and is the principal liaison between
the independent and non-management directors and the Board Chairman, the President and Chief Executive Officer, and our senior
management. The lead independent director consults with the Board Chairman regarding the schedule of board meetings, as well as
the agenda and information to be presented at such meetings. When the Board Chairman is not present, the lead independent director
acts as chairman of board meetings. Pursuant to the lead independent director charter, the individual holding that position must
meet the independence requirements set forth in the applicable rules and listing standards of Nasdaq, or such other national securities
exchange on which our securities are then listed.



Role of the Board in Risk Oversight



Our board of directors has an active role in overseeing
management of the Company’s risks, which the board administers directly as well as through various standing committees
of the board that address risks inherent in their respective areas of oversight. In particular, our board of directors is
responsible for monitoring and assessing strategic risk exposure, including information regarding our credit, liquidity and
operations and the risks associated with each. Our primary risks are currently associated with the development of our
platform technology, including our ability to raise additional capital to complete the development and potential
commercialization of product candidates using our platform technology. The audit committee of the board of directors has the
responsibility to consider and discuss our major financial risk exposures and the steps that our management has taken to
monitor and control these exposures. The audit committee also monitors compliance with legal and regulatory requirements, in
addition to oversight of the performance of the Company’s internal controls over financial reporting. The nominating
and governance committee of the board of directors monitors the effectiveness of the Company’s corporate governance
guidelines, and manages risks associated with the independence of the board of directors and potential conflicts of interest.
The compensation committee of the board of directors assesses and monitors whether any of our compensation policies and
programs has the potential to encourage excessive risk-taking. While each committee is responsible for evaluating certain
risks and overseeing management of such risks, the entire board of directors is regularly informed through committee reports
about such risks.







8







Communicating with the Board of Directors



Stockholders can mail communications to our board of directors
to our Corporate Secretary, Enumeral Biomedical Holdings, Inc., 200 CambridgePark Drive, Suite 2000, Cambridge, Massachusetts 02140,
who will forward the correspondence to each addressee.



Board Committees



Audit Committee



The audit committee was established on August 4, 2014 and currently
consists of Dr. Wolfe, as chairman, and Messrs. Sekhri and Van Nostrand. Messrs. Sekhri and Van Nostrand were appointed to replace
Dr. Buckland and Mr. Rothstein in February 2015. Dr. Buckland and Mr. Rothstein were appointed to the audit committee in August
2014 when the committee was formed following the Merger. The audit committee held 2 committee meetings during 2014.



The duties and responsibilities of the audit committee are
set forth in the charter of the audit committee. A copy of the charter of the audit committee is available under the Investors—Corporate
Governancesection of our corporate website at www.enumeral.com. Among other things,
the duties and responsibilities of the audit committee include reviewing and monitoring our financial statements and internal
accounting procedures, the selection of our independent registered public accounting firm and consulting with and reviewing the
services provided by our independent registered public accounting firm. The audit committee has sole discretion over the retention,
compensation, evaluation and oversight of our independent registered public accounting firm.



The Unites States Securities and Exchange Commission, or SEC,
and Nasdaq have established rules and regulations regarding the composition of audit committees and the qualifications of audit
committee members. Our board of directors has examined the composition of the audit committee and the qualifications of the audit
committee members in light of the current rules and regulations governing audit committees. Based upon this examination, our board
of directors has determined that each member of the audit committee is independent and is otherwise qualified to be a member of
the audit committee in accordance with the rules of the SEC and Nasdaq.



Additionally, the SEC requires that at least one member of the
audit committee have a “heightened” level of financial and accounting sophistication. Such a person is known as the
“audit committee financial expert” under the SEC’s rules. Our board of directors has determined that Dr. Wolfe
and Mr. Van Nostrand each satisfies the definition of “audit committee financial expert” in the rules and regulations
of the SEC, and each is an independent member of the board of directors and the audit committee.



Compensation Committee



The compensation committee was established on August 4, 2014
and currently consists of Mr. Sekhri, as chairman, and Dr. Buckland and Mr. Van Nostrand. Messrs. Sekhri and Van Nostrand were
appointed to replace Mr. Rothstein and Dr. Wolfe in February 2015. Mr. Rothstein and Dr. Wolfe were appointed to the compensation
committee in August 2014 when the committee was formed following the Merger. The compensation committee did not hold any committee
meetings during 2014.





9









The duties and responsibilities of the compensation
committee are set forth in the charter of the compensation committee. A copy of the charter of the compensation committee is available
under the Investors—Corporate Governancesection of our corporate website at www.enumeral.com.As discussed in its charter, among other things, the duties and responsibilities of the compensation committee include
evaluating the performance of our executive officers, determining the overall compensation of our executive officers and administering
all executive compensation programs, including, but not limited to, our incentive and equity-based plans. The compensation committee
evaluates the performance of our executive officers on an annual basis and reviews and approves on an annual basis all compensation
programs and awards relating to such officers. The compensation committee applies discretion in the determination of individual
executive compensation packages to ensure compliance with our compensation philosophy. Our chief executive officer makes recommendations
to the compensation committee with respect to the compensation packages for officers other than himself.



Nasdaq has established rules and regulations regarding
the composition of compensation committees and the qualifications of compensation committee members. Our board of directors has
examined the composition of the compensation committee and the qualifications of the compensation committee members in light of
the current rules and regulations governing compensation committees. Based upon this examination, our board of directors has determined
that each member of the compensation committee is independent and is otherwise qualified to be a member of the compensation committee
in accordance with such rules.



None of our executive officers has served as a member of the
compensation committee (or other committee serving an equivalent function) of any other entity.



Nominating and Governance Committee



The nominating and governance committee was established
in February 2015 and currently consists of Dr. Buckland, as chairman, and Messrs. Sekhri and Van Nostrand.



The duties and responsibilities of the nominating
and governance committee are set forth in the nominating and governance committee charter. A copy of the nominating and governance
committee charter is available under the Investors—Corporate Governancesection of our corporate website at
www.enumeral.com.Among other things, the duties and
responsibilities of the nominating and governance committee include identifying individuals qualified to become board members,
recommending director nominees to the board for the next annual meeting of stockholders, evaluating the overall effectiveness
of the board, developing, mentoring and evaluating our corporate governance practices, and performing such other duties as enumerated
in and consistent with its charter.



The nominating and governance committee will also
consider candidates recommended by stockholders for nomination to the board of directors. A stockholder who wishes to recommend
a candidate for nomination to the board of directors must submit such recommendation to Enumeral Biomedical Holdings, Inc., 200
CambridgePark Drive, Suite 2000, Cambridge, Massachusetts 02140; Attention: Corporate Secretary. All stockholder recommendations
of candidates for nomination for election to the board of directors must be in writing and must set forth the following: (i) the
candidate’s name, age, business address, and other contact information, (ii) the number of shares of our common stock beneficially
owned by the candidate, (iii) a complete description of the candidate’s qualifications, experience, background and affiliations,
as would be required to be disclosed in the proxy statement pursuant to Schedule 14A under the Securities Exchange Act of 1934,
as amended (the “Exchange Act”), (iv) a sworn or certified statement by the candidate in which he or she consents to
being named in the proxy statement as a nominee and to serve as director if elected, and (v) the name and address of the stockholder(s)
of record making such a recommendation and the number of shares owned by the recommending stockholder(s).





10









We believe that our board of directors as a
whole should encompass a range of talent, skill and expertise enabling it to provide sound guidance with respect to our
operations and interests. The nominating and governance committee evaluates all candidates for the board of directors by
reviewing their biographical information and qualifications. The nominating and governance committee then determines, based
on the background information and the information obtained in the interviews, whether to recommend to the board of directors
that the candidate be nominated for approval by the stockholders to fill a directorship. With respect to an incumbent
director whom the nominating and governance committee is considering as a potential nominee for re-election, the nominating
and governance committee reviews and considers the incumbent director’s service during his or her term, including the
number of meetings attended, level of participation, and overall contribution to the board of directors. The manner in which
the nominating and governance committee evaluates a potential nominee will not differ based on whether the candidate is
recommended by the directors or stockholders.



Nasdaq has established rules and regulations regarding
the composition of nominations committees and the qualifications of nominations committee members. The board of directors has examined
the composition of the nominating and governance committee and the qualifications of the members of the nominating and governance
committee in light of the current rules and regulations governing nominations committees. Based upon this examination, the board
of directors has determined that each member of the nominating and governance committee is independent and is otherwise qualified
to be a member of the nominating and governance committee in accordance with such rules.



The Company does not have a formal policy in place
with regard to the consideration of diversity of candidates for the board of directors, but the board of directors strives to nominate
candidates with a variety of complementary skills so that, as a group, the board of directors will possess the appropriate talent,
skills and expertise to oversee the Company’s business.



Code of Ethics and Business Conduct



The Company has adopted a written code of ethics and business
conduct that applies to our directors, officers and employees, including our principal executive officer, principal financial
officer, principal accounting officer or controller, or persons performing similar functions. A current copy of the code of ethics
and business conduct is available under the Investors—Corporate Governance section of our corporate website at www.enumeral.com.
A copy of the code of ethics and business conduct will also be provided to any person, without charge, upon written request sent
to Enumeral Biomedical Holdings, Inc., 200 CambridgePark Drive, Suite 2000, Cambridge, Massachusetts 02140; Attention: Corporate
Secretary. Any amendments to or waivers of the code of ethics and business conduct will be promptly posted on our website at www.enumeral.com
or in a Current Report on Form 8-K, as required by applicable laws.



Section 16(a) Beneficial Ownership Reporting
Compliance



Section 16(a) of the Exchange Act requires our directors, executive
officers and ten percent stockholders to file initial reports of ownership and reports of changes in ownership of our common stock
with the SEC. Directors, executive officers and ten percent stockholders are also required to furnish us with copies of all Section
16(a) forms that they file. As we did not register our common stock under Section 12(g) of the Exchange Act until April 3, 2015,
our directors, executive officers and ten percent stockholders were not required to file any Section 16(a) fillings during calendar
year 2014.



Related Person Transaction Approval
Policy



While we have no written policy regarding approval of
transactions between us and a related person, our board of directors, as matter of appropriate corporate governance, reviews
and approves all such transactions to the extent required by applicable rules and regulations. Generally, management would
present any related person transactions proposed to be entered into by us to the board of directors for approval. The board
may approve the transaction if it is deemed to be in the best interests of our stockholders and the Company.





11







| | ITEM 11. | EXECUTIVE
COMPENSATION.
| | -------- | -----------------------



Summary Compensation Table



The following table
sets forth information concerning the total compensation paid or accrued by the Company and Enumeral during the last two fiscal
years indicated to (i) all individuals that served as our or Enumeral’s principal executive officer or acted in a similar
capacity for the Company or Enumeral at any time during the most recent fiscal year indicated; (ii) the two most highly compensated
executive officers who were serving as executive officers of the Company or Enumeral at the end of the most recent fiscal year
indicated; and (iii) up to two additional individuals for whom disclosure would have been provided pursuant to clause (ii) above
but for the fact that the individual was not serving as an executive officer of the Company or Enumeral at the end of the most
recent fiscal year indicated.



|Name & Principal Position                                                                                                                                         |  | Fiscal Year ended December 31, |                                                                                                                                                                                                                                                     | Salary ($) |  | Stock Awards ($)(1) |                         | Option Awards ($)(2) |  | All Other Compensation ($) |                                                                                           | Total ($)
|----------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------------------------ | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ---------- |  | ------------------- | ----------------------- | -------------------- |  | -------------------------- | ----------------------------------------------------------------------------------------- | ---------
|John J. Rydzewski
                                                                                Executive Chairman                                              |  |                                | 2014 2013                                                                                                                                                                                                                                           |            |  |                     | 167,359 (3) 200,000 (5) |                      |  |                            | --
                                                                                87,480 |          
|Arthur H. Tinkelenberg, Ph.D.
                                                                            President and Chief Executive Officer                   |  |                                | 2014
                                                                                                                                                                                                                                          2013 |            |  |                     | 174,609 (3) 250,000 (5) |                      |  |                            | --
                                                                                87,480 |          
|Kevin G. Sarney (7)
                                                                            Vice President of Finance, Chief Accounting Officer and Treasurer |  |                                | 2014                                                                                                                                                                                                                                                |            |  |                     | 85,416                  |                      |  |                            | --                                                                                        |          







| | (1) | These amounts represent the aggregate fair value on the date the restricted stock was granted to each named executive officer.
| | --- | ------------------------------------------------------------------------------------------------------------------------------



| | (2) | These amounts represent the aggregate grant date fair value of (a) stock option awards granted in fiscal year 2014 under our
2014 Equity Incentive Plan and (b) with respect to Mr. Rydzewski and Dr. Tinkelenberg, warrants to purchase shares of Enumeral
Series B Preferred Stock granted in fiscal 2014, as further detailed in notes (3), (4) and (6) below. In all cases, these amounts
are computed in accordance with Financial Accounting Standards Board (“FASB”) Accounting Standards Codification Topic
718 (“Topic 718”).  These amounts do not represent the actual amounts paid to or realized by the Named Executive
Officers during fiscal year 2014, and there can be no assurance that the Topic 718 amount will ever be realized. A description
of the assumptions we used for purposes of determining grant date fair value is set forth in the notes to our consolidated financial
statements included in our Annual Report on Form 10-K for the year ended December 31, 2014, which was filed with the
SEC on March 19, 2015. The named executive officers will only realize compensation
to the extent the trading price of our common stock is greater than the exercise price of such stock options or warrants, as applicable.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------









12









| | (3) | During the first half of 2014, Mr. Rydzewski and Dr. Tinkelenberg each agreed to a reduction in salary until such time as Enumeral
obtained at least $2 million in proceeds in connection with either a financing transaction or a corporate collaboration or similar
arrangement. Mr. Rydzewski’s and Dr. Tinkelenberg’s full salaries were restored in connection with the Merger. In relation
to this salary reduction, Mr. Rydzewski and Dr. Tinkelenberg received warrants to purchase 47,058 and 58,823 shares of Enumeral
Series B Preferred Stock, respectively, as further detailed in notes (4) and (6) below. In connection with the Merger, Mr. Rydzewski’s
and Dr. Tinkelenberg’s Enumeral Series B Preferred Stock warrants were converted into warrants to purchase 137,762 and 172,204
shares of the Company’s common stock, respectively.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (4) | This amount reflects (a) $172,230 related to a July 31, 2014 grant of 300,000 incentive stock options to purchase shares of
our common stock and (b) $61,231 related to the grant of warrants to purchase 47,058 shares of Enumeral Series B Preferred Stock,
as detailed in Note (3) above.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (5) | In October 2013, Mr. Rydzewski and Dr. Tinkelenberg agreed to purchase shares of common stock from Enumeral at the fair market
value of $0.27 per share in an aggregate amount equal to the net cash salary (after standard withholding) otherwise payable to
each executive for the period between October 1, 2013 and December 31, 2013. The amounts in the summary compensation table above
include the salary that was paid to each executive for this period, which each executive subsequently paid to Enumeral in exchange
for shares of Enumeral common stock.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (6) | This amount reflects (a) $172,230 related to a July 31, 2014 grant of 300,000 incentive stock options to purchase shares of
our common stock and (b) $76,539 related to the grant of warrants to purchase 58,823 shares of Enumeral Series B Preferred Stock,
as detailed in Note (3) above.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (7) | Mr. Sarney’s employment with Enumeral commenced on July 31, 2014.
| | --- | -----------------------------------------------------------------



We have no plans in place and have never
maintained any plans that provide for the payment of retirement benefits or benefits that will be paid primarily following retirement
including, but not limited to, tax qualified deferred benefit plans, supplemental executive retirement plans, tax-qualified deferred
contribution plans and nonqualified deferred contribution plans.



Except as indicated below, we have no contracts,
agreements, plans or arrangements, whether written or unwritten, that provide for payments to the named executive officers listed
above.





Outstanding Equity Awards at Fiscal Year-End



As of December 31, 2014, we have one compensation
plan, the Enumeral Biomedical Holdings, Inc. 2014 Equity Incentive Plan, or the 2014 Plan. The 2014 Plan was approved by our stockholders
on July 31, 2014 and provides for awards of stock options, stock appreciation rights, restricted stock, restricted stock units,
performance shares, and performance units. The table below provides information with respect to the outstanding equity awards of
Mr. Rydzewski, Dr. Tinkelenberg and Mr. Sarney as of December 31, 2014.





13













|                                                                                                                             |  | Option Awards                                                             | Stock Awards                                                                                                                                                                                                                                                        
|---------------------------------------------------------------------------------------------------------------------------- |  | ------------------------------------------------------------------------- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|                                                                                                                             |  |                                                                           |                                                                                                                                                                                                                                                                     
|Name                                                                                                                         |  | Number of Securities Under- lying Unexer- cised Options Exercis- able (#) |                                                                                                                                                                                                                                                                     
|John
                                         J.
                                                                  Rydzewski |  |                                                                           | 12,504
(1)                                                                                                                                                                                                                                                          
|Arthur H. Tinkelenberg,
    Ph.D.                                                                                            |  |                                                                           | 12,504
                                                                                                                                                                                                                                                          (1)
|Kevin G. Sarney                                                                                                              |  |                                                                           | —                                                                                                                                                                                                                                                                   







| | (1) | Consists of incentive stock options granted on July 31, 2014 for 100,000 shares of our common stock, which vest monthly over
four years in 48 equal monthly installments, beginning on July 31, 2014.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | Consists of incentive stock options granted on July 31, 2014 for 200,000 shares of our common stock which vest upon satisfactory
achievement of performance-based objectives. These objectives have not yet been met.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | Represents the unvested portion of restricted stock awards made to each of Mr. Rydzewski and Dr.
Tinkelenberg in the amount of 324,000 shares of Enumeral common stock granted as of January 2, 2013, of which 13,500 shares were
immediately vested upon grant and the balance vests in 46 equal monthly installments beginning on January 26, 2013. In connection
with the Merger, Mr. Rydzewski’s and Dr. Tinkelenberg’s Enumeral restricted stock awards were each converted into restricted
stock awards for 357,086 shares of the Company’s common stock.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (4) | Represents the unvested portion of a restricted stock award made to Mr. Rydzewski in the amount
of 100,000 shares of Enumeral common stock granted as of October 1, 2011, of which (a) 1/3 of the shares underlying the restricted
stock award vested in four equal quarterly installments on December 31, 2011, March 31, 2012, June 30, 2012 and September 30, 2012;
and (b) 2/3 of the shares underlying the restricted stock award vest in 36 equal monthly installments beginning on October 31,
2012.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (5) | The market value of the unvested shares of restricted stock is calculated based on a market value
of $1.05 per share (the closing price of our common stock on the OTCQB on December 31, 2014) multiplied by the number of shares.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------











14







| | (6) | Consists of incentive stock options granted July 31, 2014 for 300,000 shares of our common stock, of which 75,000 shares vest
on July 31, 2015 and 225,000 shares vest monthly over three years in 36 equal monthly installments beginning on August 31, 2015.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (7) | Consists of incentive stock options granted July 31, 2014 for 50,000 shares of our common stock
which shall vest upon satisfactory achievement of performance-based objectives. These objectives have not yet been met.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



The following table sets forth certain information with respect
to grants of stock options to the Named Executive Officers during fiscal year 2014:





|GRANTS OF PLAN BASED AWARDS TABLE
|---------------------------------
|                                 
|Name                             
|John J. Rydzewski                
|Arthur H. Tinkelenberg, Ph. D.   
|Kevin G. Sarney                  







| | (1) | These amounts represent the aggregate grant date fair value of (a) stock option awards granted in fiscal year 2014 under our
2014 Equity Incentive Plan and (b) with respect to Mr. Rydzewski and Dr. Tinkelenberg, warrants to purchase shares of Enumeral
Series B Preferred Stock granted in fiscal 2014, as further detailed in note (2) below. In all cases, these amounts are computed
in accordance with FASB ASC Topic 718. A description of the assumptions used for purposes of determining grant date fair value
is set forth in the notes to our consolidated financial statements included in our Annual Report on Form 10-K for the year
ended December 31, 2014, which was filed with the SEC on March 19, 2015. The named executive officers will only realize
compensation to the extent the trading price of our common stock is greater than the exercise price of such stock options or warrants,
as applicable.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | (2) | On April 15, 2014, Mr. Rydzewski and Dr. Tinkelenberg received warrants to purchase 47,058 and 58,823 shares of Enumeral Series
B Preferred Stock, respectively, in relation to the executives agreeing to take a temporary salary reduction, as detailed in the
Summary Compensation Table above. In connection with the Merger, on July 31, 2014 Mr. Rydzewski’s and Dr. Tinkelenberg’s
warrants to purchase Enumeral Series B Preferred Stock were converted into warrants to purchase 137,762 and 172,204 shares of our
common stock, respectively. These warrants were granted outside of our 2014 Plan.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------







15







Employment Agreements



John J. Rydzewski



On July 21, 2014, Enumeral and Mr. Rydzewski amended and restated
his existing employment agreement, dated as of October 1, 2011. His amended and restated employment agreement provides, following
the closing of the Merger and PPO, for (i) a term of employment of two years from July 21, 2014 that automatically renews for additional
two-year terms unless terminated by Enumeral or Mr. Rydzewski, (ii) a base salary of $262,500, (iii) entitlement to participate
in bonus plans which are approved by the Board for Enumeral employees generally, (iv) a stock option award to purchase 100,000
shares of Enumeral’s or, if applicable, the Company’s common stock with an exercise price equal to the fair market
value of Enumeral’s common stock as determined by Enumeral’s board of directors and vesting in 48 equal monthly installments
over 4 years beginning on July 31, 2014, (v) an incentive stock option award to purchase 200,000 shares of Enumeral’s or,
if applicable, the Company’s common stock with an exercise price equal to the fair market value of Enumeral’s common
stock as determined by Enumeral’s board of directors and vesting subject to performance-based criteria set forth in the employment
agreement, and (vi) a warrant to purchase 47,058 shares of Enumeral’s Series B Preferred Stock subject to vesting conditions
set forth in the employment agreement and exercisable at $2.125 per share.



Pursuant to the October 1, 2011 employment agreement, Mr. Rydzewski
received (a) a restricted stock grant of 100,000 shares and (b) a stock option award to purchase 50,000 shares of Enumeral’s
common stock, in each case subject to the vesting conditions set forth in the employment agreement and with an exercise price equal
to the fair market value of Enumeral’s common stock as determined by Enumeral’s board of directors. Mr. Rydzewski exercised
his option to purchase 50,000 options on July 25, 2012. Additionally, on January 2, 2013, Mr. Rydzewski received a restricted stock
grant of 324,000 shares of Enumeral common stock, of which 13,500 shares were immediately vested upon grant and the balance vests
in 46 equal monthly installments beginning on January 26, 2013.



Contemporaneous with the closing of the Merger and PPO, Mr.
Rydzewski’s warrants and options to purchase shares of Enumeral common stock, as well as restricted grants of Enumeral common
stock, were converted into warrants and options to purchase shares of our common stock, as well as restricted grants of our common
stock, respectively.



On July 31, 2014, the Company agreed to assume the obligations
of Enumeral under the amended and restated employment agreement.



Arthur H. Tinkelenberg, Ph.D.



On July 21, 2014, Enumeral and Dr. Tinkelenberg amended
and restated his existing employment agreement, dated as of July 1, 2010. His amended and restated employment agreement
provides, following the closing of the Merger and PPO, for (i) a term of employment of two years from July 21, 2014 that
automatically renews for additional two-year terms unless terminated by Enumeral or Dr. Tinkelenberg, (ii) a base salary of
$262,500, (iii) entitlement to participate in bonus plans which are approved by the Board for Enumeral employees generally,
(iv) a stock option award to purchase 100,000 shares of Enumeral’s or, if applicable, the Company’s common stock
with an exercise price equal to the fair market value of Enumeral’s common stock as determined by Enumeral’s
board of directors and vesting in 48 equal monthly installments over 4 years beginning on July 31, 2014, (v) an incentive
stock option award to purchase 200,000 shares of Enumeral’s or, if applicable, the Company’s common stock with an
exercise price equal to the fair market value of Enumeral’s common stock as determined by Enumeral’s board of
directors and vesting subject to performance-based criteria set forth in the employment agreement, and (vi) a warrant to
purchase 58,823 shares of Enumeral’s Series B Preferred Stock subject to vesting conditions set forth in the employment
agreement and exercisable at $2.125 per share.





16







Pursuant to the July 1, 2010 employment
agreement, Dr. Tinkelenberg received (a) a restricted stock grant of 393,750 shares and (b) a stock option award to purchase 51,576
shares of Enumeral’s common stock, in each case subject to the vesting conditions set forth in the employment agreement (and
which were fully vested prior to the closing of the Merger) and with an exercise price equal to the fair market value of Enumeral’s
common stock as determined by Enumeral’s board of directors. Dr. Tinkelenberg exercised his 51,576 options on July 27, 2012.
Additionally, on January 2, 2013, Dr. Tinkelenberg received a restricted stock grant of 324,000 shares of Enumeral common stock,of which 13,500 shares were immediately vested upon grant and the balance vests in 46 equal monthly installments beginning
on January 26, 2013.



Contemporaneous with the closing of the
Merger and PPO, Dr. Tinkelenberg’s warrants and options to purchase shares of Enumeral common stock, as well as restricted
grants of Enumeral common stock, were converted into warrants and options to purchase shares of our common stock, as well as restricted
grants of our common stock, respectively.



On July 31, 2014, we agreed to assume the
obligations of Enumeral under the amended and restated employment agreement.



Kevin G. Sarney



Pursuant to his offer letter, dated July
25, 2014, Mr. Sarney serves as our Vice President of Finance and Chief Accounting Officer. Mr. Sarney’s offer letter provides
that Mr. Sarney shall be entitled to a base salary of $200,000 and a target bonus of 25% of his base salary based on achievement
of target milestone parameters, with such bonus being determined at the discretion of our board of directors. Pursuant to the offer
letter, Mr. Sarney received an incentive stock option to purchase 350,000 shares of our common stock with an exercise price at
the then fair market value of our common stock as determined by the board of directors. Of the 350,000 options, 75,000 vest on
July 31, 2015 and 225,000 vest monthly over three years in 36 equal monthly installments beginning on August 31, 2015. The remaining
50,000 options vest upon satisfactory achievement of performance-based objectives.



Potential Payments upon Termination or Change in Control



Employment Agreements of Mr. Rydzewski
and Dr. Tinkelenberg



If Mr. Rydzewski’s or Dr. Tinkelenberg’s
employment was terminated for cause, death, disability or resigns for any reason (other than resignation for Good Reason, as such
term is defined below), their employment agreements provide that such executive would have received the following:



| | · | any accrued but unpaid salary through the date of termination plus any accrued vacation;
| | - | ----------------------------------------------------------------------------------------



| | · | any earned and declared but unpaid bonus for the most recently completed year;
| | - | ------------------------------------------------------------------------------



| | · | reimbursement of any unreimbursed expenses; and
| | - | -----------------------------------------------



| | · | benefits in accordance with the terms of the applicable plans and programs of the Company.
| | - | ------------------------------------------------------------------------------------------



In addition, all of the
executive’s unvested stock or options shall immediately terminate and be cancelled.







17







If Mr. Rydzewski’s or Dr. Tinkelenberg’s
employment is terminated by the Company other than for Cause or by Mr. Rydzewski or Dr. Tinkelenberg for Good Reason where a Change
in Control has not occurred (as such terms are defined below), and provided that the executive executes the Company’s form
of termination and release agreement, the executive will be entitled to the following:



| | · | base salary for the greater of twelve months or the remaining time until two years from the date
of the closing of the Merger and PPO (the “Severance Period”);
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | all earned and declared but unpaid bonuses which are due and payable, including a pro rata portion
of the current year’s potential bonus, calculated based on the then-current target bonus percentage (but no less than 40%),
payable in lump sum, based upon achievement of then-current target milestones through the termination date of employment as determined
in good faith by the Company’s compensation committee or board of directors, as applicable;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | continued coverage for the Severance Period of all Company group insurance (including life, health,
accident and disability insurance) and, to the extent permitted by applicable law, all other employee benefit plans, programs or
arrangements in which the executive was participating at any time during the six month period preceding the termination of employment,
provided that the Company will no longer be obligated to fund the cost of premiums for such plans and benefits in the event that
the executive becomes eligible for similar insurance or other employee benefits from a new employer during the Severance Period;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | continued vesting of any non-vested stock options and restricted stock granted pursuant to the
employment agreement for the Severance Period pursuant to the vesting schedule set forth therein, as well as extension of the period
to exercise vested stock options until five years following the expiration of the Severance Period, provided that if the executive
breaches the terms of his employment agreement, all of the executive’s unvested options and shares of restricted stock will
be immediately forfeited; and
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | payment for all accrued but unused vacation on the termination date of employment.
| | - | ----------------------------------------------------------------------------------



In addition, if a Change in Control occurs
during the Severance Period, all non-vested stock options and shares of restricted stock shall immediately accelerate and become
exercisable or non-forfeitable, as the case may be.



If Mr. Rydzewski’s or Dr. Tinkelenberg’s
employment is terminated, or Mr. Rydzewski or Dr. Tinkelenberg resigned for Good Reason where a Change in Control has occurred,
and provided that the executive executes the Company’s form of termination and release agreement, the executive will receive:



| | · | an amount equal to one year of base salary, payable immediately in one lump sum;
| | - | --------------------------------------------------------------------------------



| | · | all bonuses which are due and payable, including the full amount of the current year’s target
incentive bonus as if the then-current target milestones were achieved for the applicable year;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | continued coverage for the Severance Period of all Company group insurance (including life, health,
accident and disability insurance) and, to the extent permitted by applicable law, all other employee benefit plans, programs or
arrangements in which the executive was participating at any time during the six month period preceding the termination of employment;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------







18







| | · | all non-vested stock options or restricted stock shall vest immediately and become exercisable
or non-forfeitable and shall be exchanged for cash or freely tradable stock of the acquiring company, provided that in the event
it is not possible for such stock options or restricted stock to be exchanged for cash or freely tradable stock of the acquiring
company, the period to exercise vested stock options shall be extended until five years following the date such shares vested;
and
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | payment for all accrued but unused vacation on the termination date of employment.
| | - | ----------------------------------------------------------------------------------



“Cause” is defined in Mr. Rydzewski’s
and Dr. Tinkelenberg’s employment agreements as:



| | · | the executive’s conviction by a court of competent jurisdiction of any felony involving dishonesty,
breach of trust or misappropriation or entry of a plea of nolo contendere thereto;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | the commission of an act of fraud upon, breaching the duty of loyalty to, the Company or any of
its subsidiaries;
| | - | -----------------------------------------------------------------------------------------------------------------



| | · | a conviction for willful violation of any law, rule or regulation governing operation of the Company
or any of its subsidiaries that is punishable by six months or more imprisonment;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | the substantial and continuing failure or refusal of the executive, after seven days’ written
notice thereof, to perform his or her job duties and responsibilities which failure or refusal is committed in bad faith (other
than failure or refusal resulting from incapacity due to physical disability or mental illness);
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | the executive’s breach of his employment agreement that continues for more than seven days
after written notice has been given to the executive; or
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------



| | · | the deliberate and willful disregard for our rules or policies of the Company that results in a
material and substantial loss, damage or injury to the Company.
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------



“Good Reason” is defined in
Mr. Rydzewski’s and Dr. Tinkelenberg’s employment agreements as:



| | · | a reduction in the executive’s then-current base salary or target bonus percentage;
| | - | -----------------------------------------------------------------------------------



| | · | any failure to offer to the executive at least the same level of benefits offered to similarly
situated employees;
| | - | ------------------------------------------------------------------------------------------------------------------



| | · | a significant diminution in the executive’s managerial authority, duties and responsibilities
following a Change in Control of the Company;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------



| | · | the relocation of the executive’s primary business location to a location outside of the
New York metropolitan area;
| | - | --------------------------------------------------------------------------------------------------------------------



| | · | failure to pay to the executive any portion of his current base salary, bonus or benefits within
20 days of when such compensation is due, based upon the payment terms currently in effect, unless such payment is prohibited by
law, regulation or rule; or
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | the Company’s failure to obtain a reasonably satisfactory agreement from any successor to
the Company to assume and agree to perform the executive’s employment agreement.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------







19







“Change in Control” is defined
in Mr. Rydzewski’s and Dr. Tinkelenberg’s employment agreements as:



| | · | the merger or consolidation of the Company with another entity, where, immediately after the transaction:
| | - | ---------------------------------------------------------------------------------------------------------



| | o | the Company’s stockholders immediately prior to the merger or consolidation beneficially own, directly or indirectly,
less than 50% of the voting shares of the surviving entity in the consolidation or merger (or of its ultimate parent corporation,
if any); or
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | o | persons who constitute the Company’s board of directors prior to the transaction cease to constitute at least a majority
of the board of directors of the surviving entity in the consolidation or merger (or of its ultimate parent corporation, if any);
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | sale, lease or other transfer of all or substantially all of the Company’s assets or the exclusive
license of all or substantially all of its patents, provisional patent applications and patent applications for substantially all
uses to a third party;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | any person (other than the Company, any of its subsidiaries, or any trustee, fiduciary or other person
or entity holding securities under any employee benefit plan), together with all affiliates and associates of such person, becomes
the beneficial owner of Company securities representing 50% or more of the combined voting power of the Company’s then outstanding
securities having the right to vote in an election of the Company’s board of directors.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Director Compensation



Non-employee directors’ compensation
generally is determined and awarded by our board of directors. Our board is responsible for, among other things, reviewing, evaluating
and designing a director compensation package of a reasonable total value, typically based on comparisons with similar firms, and
aligned with long-term interests of our stockholders, and reviewing director compensation levels and practices and considering,
from time to time, changes in such compensation levels and practices. These matters also include making equity awards to non-employee
directors from time to time under our equity-based plans. As part of these responsibilities, our board may request that our management
provide the board with recommendations on non-employee director compensation and/or common director compensation practices, although
the board retains its ultimate authority to take compensatory actions.



Prior to the Merger, the Company did not pay
its non-employee directors an annual retainer. On August 4, 2014, our board of directors approved a director compensation program
for non-employee directors. Newly elected non-employee board members will receive an option to purchase 60,000 shares of our common
stock that will vest on a monthly basis over three years from date of grant, and a one-time option grant of 20,000 shares that
will be fully vested upon their election to the board. Non-employee directors shall also be entitled an annual retainer at the
rate of $20,000 per annum, which individual directors may elect to take in the form of cash, restricted stock or options to purchase
common stock. The election shall be made on an annual basis at least 30 days prior to the beginning of a fiscal year. Compensation
taken in the form of restricted stock or options to purchase common stock shall vest over one year in four equal quarterly amounts
on the first day of each fiscal quarter, provided the individual continues to serve as a director.



Directors who serve as members of the
audit committee are entitled to additional compensation at the rate of $3,000 per annum, with the chairman of the audit
committee being compensated at the rate of $6,000 per annum. Directors who serve as members of the compensation committee are
entitled to additional compensation at the rate of $2,000 per annum, with the chairman of the compensation committee being
compensated at the rate of $4,000 per annum. A director who serves in the position of lead independent director shall be
entitled to compensation at the rate of $6,000 per annum. Pursuant to the terms of the director compensation program, all
such board and committee fees shall be paid quarterly in advance.





20







On August 4, 2014, pursuant to the adoption
of the director compensation program discussed above, we granted each of Mr. Rothstein and Drs. Buckland and Wolfe an option to
purchase 20,000 shares of our common stock with an exercise price of $1.00 per share which are fully vested. In addition, on August
4, 2014 we also granted Mr. Wolfe an option to purchase 60,000 shares of our common stock with an exercise price of $1.00 per share,
of which 36,667 shares were vested on the grant date and the remaining 23,333 shares vest monthly over a fourteen (14) month period
commencing on September 1, 2014.



In connection with the Merger, John Rydzewski
was elected Chairman of the Board of Directors and, pursuant to the adoption of his employment agreement, was granted an option
to purchase 300,000 shares of our common stock. Also in connection with the Merger, Arthur Tinkelenberg was elected a director
and, pursuant to the adoption of his employment agreement, was granted an option to purchase 300,000 shares of our common stock.
Each of the option awards were made under our 2014 Plan. Additional information regarding the option awards may be found above
under “Employment Agreements.”



The following table sets forth compensation
actually paid to Enumeral non-employee directors during fiscal year 2014:



|Name                       |  | Fees earned or paid in cash
                                                                                ($)(1) |            | Option awards ($)(2) |  | Total ($)
|-------------------------- |  | ------------------------------------------------------------------------------------------------------------------ | ---------- | -------------------- |  | ---------
|Barry Buckland, Ph.D.      |  |                                                                                                                    | 30,917 (3) |                      |  |          
|Allan Rothstein            |  |                                                                                                                    | 13,750     |                      |  |          
|Paul J. Sekhri (4)         |  |                                                                                                                    | —          |                      |  |          
|Robert L. Van Nostrand (4) |  |                                                                                                                    | —          |                      |  |          
|Daniel B. Wolfe, Ph.D.     |  |                                                                                                                    | 11,667     |                      |  |          





| | (1) | Except as otherwise specifically noted, the amounts set forth in this column represent fees paid for service on our board of
directors and committees thereof.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | These amounts represent the aggregate grant date fair value of stock option awards granted in fiscal year 2014 under the 2014
Plan, computed in accordance with FASB ASC Topic 718.  These amounts do not represent the actual amounts paid to or realized
by the directors during fiscal year 2014, and there can be no assurance that the Topic 718 amount will ever be realized. A description
of the assumptions we used for purposes of determining grant date fair value is set forth in the notes to our consolidated financial
statements included in our Annual Report on Form 10-K for the year ended December 31, 2014, which was filed with the
SEC on March 19, 2015.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | Represents the aggregate of (i) $20,500 paid to Dr. Buckland pursuant to his consulting and Scientific Advisory Board agreements
with the Company and (ii) $10,417 paid to Dr. Buckland for service on our board of directors and committees thereof.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (4) | Messrs. Van Nostrand and Sekhri joined our board on December 1, 2014 and December 16, 2014, respectively.
| | --- | ---------------------------------------------------------------------------------------------------------







21







| | ITEM 12. | SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS.
| | -------- | -----------------------------------------------------------------------------------------------



Beneficial ownership is determined in accordance with the rules
of the SEC and generally includes voting or investment power with respect to securities. In accordance with SEC rules, shares of
our common stock which may be acquired upon exercise of stock options or warrants which are currently exercisable or which become
exercisable within 60 days of the date of the table below are deemed beneficially owned by the holders of such options and warrants
and are deemed outstanding for the purpose of computing the percentage of ownership of such person, but are not treated as outstanding
for the purpose of computing the percentage of ownership of any other person. Subject to community property laws, where applicable,
the persons or entities named in the tables below have sole voting and investment power with respect to all shares of our common
stock indicated as beneficially owned by them.



The following table sets forth information with respect to the
beneficial ownership of our common stock as of April 21, 2015 (the “Determination Date”), by (i) each stockholder known
by us to be the beneficial owner of more than 5% of our common stock (our only classes of voting securities), (ii) each of our
directors and executive officers, and (iii) all of our directors and executive officers as a group. To the best of our knowledge,
except as otherwise indicated, each of the persons named in the table has sole voting and investment power with respect to the
shares of our common stock beneficially owned by such person, except to the extent such power may be shared with a spouse. To our
knowledge, none of the shares listed below are held under a voting trust or similar agreement, except as noted. In addition, to
our knowledge there is no arrangement, including any pledge by any person of securities of the Company or any of its parents, the
operation of which may at a subsequent date result in a change in control of the Company.



|Title of class |  | Name and address of beneficial owner (1)                                                                |  | Amount and nature of beneficial ownership |            | Percent of class (2)
|-------------- |  | ------------------------------------------------------------------------------------------------------- |  | ----------------------------------------- | ---------- | --------------------
|Common Stock   |  | Harris & Harris Group, Inc. (3) 1450 Broadway, 24th Floor New York, NY 10018                            |  |                                           | 9,794,824  |                     
|Common Stock   |  | Daniel B. Wolfe, Ph.D. c/o Harris & Harris Group, Inc. (3) 1450 Broadway, 24th Floor New York, NY 10018 |  |                                           | 9,794,824  |                     
|Common Stock   |  | Mark Tompkins (4)                                                                                       |  |                                           | 5,195,348  |                     
|Common Stock   |  | Allan Rothstein (5)                                                                                     |  |                                           | 2,107,964  |                     
|Common Stock   |  | John J. Rydzewski (6)                                                                                   |  |                                           | 1,476,346  |                     
|Common Stock   |  | Arthur H. Tinkelenberg, Ph.D. (7)                                                                       |  |                                           | 1,467,146  |                     
|Common Stock   |  | Barry Buckland, Ph.D. (8)                                                                               |  |                                           | 306,886    |                     
|Common Stock   |  | Paul J. Sekhri (9)                                                                                      |  |                                           | 30,002     |                     
|Common Stock   |  | Robert L. Van Nostrand (10)                                                                             |  |                                           | 30,002     |                     
|Common Stock   |  | Derek  Brand (11)                                                                                       |  |                                           | 279,261    |                     
|Common Stock   |  | Anhco Nguyen, Ph.D. (12)                                                                                |  |                                           | 129,246    |                     
|Common Stock   |  | Kevin G. Sarney (13)                                                                                    |  |                                           | —          |                     
|Common Stock   |  | All of our directors and executive officers as a group (10 persons) (14)                                |  |                                           | 15,621,677 |                     





*	Less than 1%



| | (1) | Unless otherwise set forth above, the address for each of the persons or entities listed above is c/o Enumeral Biomedical Holdings,
Inc., 200 CambridgePark Drive, Suite 2000, Cambridge, MA 02140.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------







22







| | (2) | Applicable percentage ownership is based on 51,607,665 shares of Common Stock outstanding as of the Determination Date, together
with securities exercisable or convertible into shares of Common Stock within 60 days after the Determination Date, for each shareholder.
Beneficial ownership is determined in accordance with the rules of the SEC and generally includes voting or investment power with
respect to securities.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | Consists of 7,966,368 shares of common stock owned directly by Harris & Harris Group, Inc. (“Harris”), 255,120
shares that Harris has the right to acquire upon the exercise of warrants that are exercisable within 60 days of the Determination
Date and 1,500,000 shares that Harris has the right to acquire upon the exercise of PPO Warrants that are exercisable within 60
days of the Determination Date, and 73,336 shares of common stock that Daniel B. Wolfe, a director of the Company, has the right
to acquire upon the exercise of options that is exercisable within 60 days of the Determination Date provided however that Dr.
Wolfe has assigned the economic benefit of the option to Harris. 7,966,368 shares of common stock and warrants to purchase 1,755,120
shares of common stock owned by Harris is pledged as security for a margin account. Dr. Wolfe, along with Douglas W. Jamison, Alexei
Andreev and Misti Ushio, are managing directors of Harris and as such may be deemed to have shared voting and dispositive power
over the share of common Stock beneficially owned by Harris. However, each of such persons disclaims beneficial ownership over
such shares of Common Stock except as to their pecuniary interest therein of 325,651, 375,029, 301,576 and 292,602 shares, respectively.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (4) | Consists of 3,995,348 shares of common stock owned directly by Mr. Tompkins and 1,200,000 shares that Mr. Tompkins has the
right to acquire upon the exercise of warrants that are exercisable within 60 days of the Determination Date, based on information
provided by Mr. Tompkins as of April 8, 2015. Mr. Tompkins does not serve as an officer or director of the Company.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (5) | Consists of 1,728,960 shares of common stock owned directly by Mr. Rothstein, 270,427 shares that Mr. Rothstein has the right
to acquire upon the exercise of warrants that are exercisable within 60 days of the Determination Date, 50,000 shares that Mr.
Rothstein has the right to acquire upon the exercise of PPO warrants that are exercisable within 60 days of the Determination Date,
and 58,577 shares that Mr. Rothstein has the right to acquire
upon the exercise of options that are exercisable within 60 days of the Determination Date.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------







| | (6) | Consists of 1,264,637 shares of common stock owned directly by Mr. Rydzewski, 188,785 shares that Mr. Rydzewski has the right
to acquire upon the exercise of warrants that are exercisable within 60 days of the Determination Date and 22,924 shares that Mr.
Rydzewski has the right to acquire upon the exercise of options that are exercisable within 60 days of the Determination Date.
Does not include shares that Mr. Rydzewski has the right to acquire upon exercise of options subject to performance based criteria,
which criteria has not yet been achieved.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------







23







| | (7) | Consists of 1,272,018 shares of common stock owned directly by Dr. Tinkelenberg, 172,204 shares that Dr. Tinkelenberg has the
right to acquire upon the exercise of warrants that are exercisable within 60 days of the Determination Date and 22,924 shares
that Dr. Tinkelenberg has the right to acquire upon the exercise of options that are exercisable within 60 days of the Determination
Date. Does not include shares that Dr. Tinkelenberg has the right to acquire upon exercise of options subject to performance based
criteria, which criteria has not yet been achieved.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (8) | Consists of 68,882 shares of common stock owned directly by Dr. Buckland and 175,286 shares of common stock owned by BiologicB,
LLC, a company wholly-owned by Mr. Buckland and 62,718 shares that Dr. Buckland has the right to acquire upon the exercise of options
that are exercisable within 60 days of the Determination Date.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (9) | Consists of 30,002 shares that Mr. Sekhri has the right to acquire upon the exercise of options that are exercisable within
60 days of the Determination Date.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (10) | Consists of 30,002 shares that Mr. Van Nostrand has the right to acquire upon the exercise of options that are exercisable
within 60 days of the Determination Date.
| | ---- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (11) | Consists of 279,261 shares that Mr. Brand has the right to acquire upon the exercise of options that are exercisable within
60 days of the Determination Date. Terms of certain options are described in such option agreements. Does not include shares that
Mr. Brand has the right to acquire upon exercise of options subject to performance based criteria, which criteria has not yet been
achieved.
| | ---- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (12) | Consists 129,246 shares that Dr. Nguyen has the right to acquire upon the exercise of options that are exercisable within 60
days of the Determination Date. Terms of certain options are described in such option agreements. Does not include shares that
Dr. Nguyen has the right to acquire upon exercise of options subject to performance based criteria, which criteria has not yet
been achieved
| | ---- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (13) | Mr. Sarney started with the Company on July 31, 2014. As of the date hereof, Mr. Sarney did not beneficially own any shares.
| | ---- | ----------------------------------------------------------------------------------------------------------------------------



| | (14) | Shares are subject to the Voting Agreement as described above under “Item 10 - Director Relationships and Arrangements.”
| | ---- | ------------------------------------------------------------------------------------------------------------------------



Equity Compensation Plan Information



The following table provides information
with respect to the 2014 Plan, as well as grants outside of the 2014 Plan, as of December 31, 2014:







24









|Equity Compensation Plan Information                       | 
|---------------------------------------------------------- | 
|Plan Category                                              | 
|Equity compensation plans approved by security holders     | 
|Equity compensation plans not approved by security holders | 
|Total                                                      | 



| | (1) | A total of 8,100,000 shares of our common stock were authorized for issuance pursuant to awards under
the 2014 Plan as of December 31, 2014, of which 2,730,963 stock options have been awarded to participants under the 2014 Plan as
of December 31, 2014. The amount listed above does not include 345,699 shares of restricted stock granted under the 2014 Plan as
of December 31, 2014 and 84,596 shares previously granted pursuant to restricted stock awards under the 2014 Plan for which restrictions
have lapsed as of December 31, 2014.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | On April 15, 2014, Mr. Rydzewski and Dr. Tinkelenberg received warrants to purchase 47,058 and 58,823
shares of Enumeral Series B Preferred Stock, respectively, in relation to the executives agreeing to take a temporary salary reduction,
as detailed in the Summary Compensation Table above. In connection with the Merger, on July 31, 2014 Mr. Rydzewski’s and
Dr. Tinkelenberg’s warrants to purchase Enumeral Series B Preferred Stock were converted into warrants to purchase 137,762
and 172,204 shares of our common stock, respectively. These warrants were granted outside of our 2014 Plan.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | ITEM 13. | CERTAIN
RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE.
| | -------- | --------------------------------------------------------------------------



SEC rules require us to disclose any transaction or currently
proposed transaction in which we are a participant and in which any related person has or will have a direct or indirect material
interest involving the lesser of $120,000.00 or one percent (1%) of the average of our total assets as of the end of last two completed
fiscal years. A related person is any executive officer, director, nominee for director, or holder of 5% or more of our common
stock, or an immediate family member of any of those persons.



We completed the following offerings in which a person who was
a related party at the time of the transaction participated (share and per share numbers below are without giving effect to the
conversion of all Enumeral shares into shares of our common stock in the Merger):



| | (a) | During April and September, 2013, Enumeral completed a private placement with 17 accredited investors pursuant to which we
sold 1,833,798 shares of Series A-2 Preferred Stock, at price of $1.45 per share, or approximately $2,659,007 in the
aggregate. In connection with the Merger, each share of Series A-2 Preferred Stock was converted into 1.997594 shares of our common
stock, representing 3,663,177 shares in the aggregate. Mr. Rydzewski, Dr. Tinkelenberg, Mr. Rothstein, who became a director of
Enumeral in September 2013, Jay and Tammy Levine, Mr. Rothstein’s brother-in-law and sister, and Harris & Harris Group,
Inc. purchased 34,483, 34,483, 100,000, 100,000, and 724,138, respectively, of the securities in this offering.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------







25







| | (b) | During February and March 2014 and to fund operations prior to the Series B offering, Enumeral completed a private placement
with 7 accredited investors pursuant to which we sold $750,000 principal amount of 12% Convertible Promissory Notes (the “Bridge
Notes”). The Bridge Notes had a maturity of July 1, 2015 or if earlier, a Liquidity Event (as defined in Enumeral’s
charter) and bore interest at the rate of 12% payable annually and automatically converts into either Series B Preferred Stock
or common stock, at the option of holder of the Bridge Notes, upon achieving certain fundraising goals. Each noteholder also received
a warrant to purchase 925.924 shares of common stock, for each $1,000 principal amount of Bridge Notes, or 694,443 in the aggregate.
The warrants have an exercise price of $0.27 per share. In connection with the Merger, the principal and interest on the Bridge
Notes were converted into 3,230,869 shares of our common stock. Mr. Rydzewski, Mr. Ostuni, Mr. Rothstein, Michael Weiss, a director
of Enumeral at the time, and Harris & Harris Group, Inc. purchased $50,000 principal amount of the Bridge Notes and warrants
to purchase 46,296 shares of Enumeral common stock, $10,000 principal amount of the Bridge Notes and warrants to purchase 9,259
shares of Enumeral common stock, $265,000 principal amount of the Bridge Notes and warrants to purchase 245,370 shares of Enumeral
common stock, $50,000 principal amount of the Bridge Notes and warrants to purchase 46,296 shares of Enumeral common stock, and
$250,000 principal amount of the Bridge Notes and warrants to purchase 231,481 shares of Enumeral common stock, respectively, in
this offering.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (c) | During April 2014, Enumeral completed a private placement of 948,823 shares of Series B Preferred Stock. Harris & Harris
Group, Inc. purchased 470,588 of the securities in this offering.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



In September 2014, the Company and Dr. Buckland entered into
a Scientific Advisory Board Agreement (the “SAB Agreement”) pursuant to which Dr. Buckland serves as chairman of our
Scientific Advisory Board. The SAB Agreement supersedes Dr. Buckland’s previous consulting agreement entered into with Enumeral
in April 2011, as subsequently amended, pursuant to which Dr. Buckland received 159,045 shares of Enumeral restricted common stock,
as well as cash compensation for consulting services. Pursuant to the terms of the SAB Agreement, Dr. Buckland will receive compensation
on an hourly or per diem basis, either in cash or, at Dr. Buckland’s election, in options to purchase the Company’s
common stock, provided that any such compensation will not exceed $100,000 in any continuous twelve month period. The SAB Agreement
has a term of two years.



In September 2013, Enumeral entered into a consulting agreement
with Mr. Rothstein and his father, Norman Rothstein, to consult with Enumeral’s chief executive officer and senior members
of management on various financing-related matters. Each of these individuals received 500,000 shares of Enumeral common stock
valued at $0.27 per share as payment for their services provided to Enumeral, with one third vesting upon the execution of the
consulting agreement in September 2013, one third vesting on December 14, 2013, and one third vesting on March 10, 2014. The consulting
agreement was terminated on July 30, 2014.



Director Independence



While we are currently quoted on the over-the-counter
market, we have adopted the corporate governance standards of a listed company on the Nasdaq Stock Market, or Nasdaq. These
standards require that a majority of the members of our board of directors be “independent,” as Nasdaq defines
that term, and that our board make an affirmative determination as to the independence of each director. Consistent with
these rules, our board of directors undertook its annual review of director independence in February 2015. During the review,
our board considered relationships and transactions during 2014 and during the past three fiscal years between each director
or any member of his or her immediate family, on the one hand, and the Company and its subsidiaries and affiliates, on the
other hand. The purpose of this review was to determine whether any such relationships or transactions were inconsistent with
a determination that the director is independent. Based on this review, our board of directors determined that Drs. Buckland
and Wolfe and Messrs. Sekhri and Van Nostrand are independent under the criteria established by Nasdaq and by our board of
directors.





26







| | ITEM 14. | PRINCIPAL
ACCOUNTING FEES AND SERVICES.
| | -------- | ---------------------------------------



As a matter of corporate governance, we will not engage our
independent registered public accounting firm to render audit or non-audit services unless the service is specifically approved
in advance by the audit committee.



The following table shows the fees billed by Friedman LLP for
audit and other services provided for the fiscal year ended December 31, 2014. All of the services described in the following fee
table were approved in conformity with the audit committee’s pre-approval process.



|Type of Fee            |  | 2014
|---------------------- |  | ----
|                       |  |     
|Audit Fees (1)         |  | $   
|Audit Related Fees (2) |  |     
|Tax Fees (3)           |  |     
|All Other Fees (4)     |  |     
|Total                  |  | $   





| | (1) | Audit Services – This category includes the audit of the Company’s annual financial statements and services that
are normally provided by independent auditors in connection with the engagement for fiscal years.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | Audit Related Services – This category consists of fees reasonably related to the performance of the audit or review
of the Company’s financial statements that are not reported as “Audit Fees.”
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | Tax Services – This category consists of tax compliance, tax advice and tax planning work.
| | --- | ------------------------------------------------------------------------------------------



| | (4) | All Other Fees – This category consists of fees for other miscellaneous items.
| | --- | ------------------------------------------------------------------------------



The following table sets forth the approximate aggregate fees
for professional audit services rendered by Anton & Chia, LLP for the audit and other service for the fiscal year ended October
31, 2013:



|Type of Fee            |  | 2013
|---------------------- |  | ----
|                       |  |     
|Audit Fees (1)         |  | $   
|Audit Related Fees (2) |  |     
|Tax Fees (3)           |  |     
|All Other Fees (4)     |  |     
|Total                  |  | $   







27







| | (1) | Audit Services – This category includes the audit of the Company’s annual financial statements and services that
are normally provided by independent auditors in connection with the engagement for fiscal years.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | Audit Related Services – This category consists of fees reasonably related to the performance of the audit or review
of the Company’s financial statements that are not reported as “Audit Fees.”
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | Tax Services – This category consists of tax compliance, tax advice and tax planning work.
| | --- | ------------------------------------------------------------------------------------------



| | (4) | All Other Fees – This category consists of fees for other miscellaneous items.
| | --- | ------------------------------------------------------------------------------



PART
IV



| | ITEM 15. | EXHIBITS,
FINANCIAL STATEMENT SCHEDULES.
| | -------- | ----------------------------------------



(a)(1)	   Financial statements.



| | · | Report of Independent Registered Public Accounting Firm
| | - | -------------------------------------------------------

| | · | Consolidated Balance Sheets at December 31, 2014 and 2013
| | - | ---------------------------------------------------------

| | · | Consolidated Statements of Operations and Comprehensive Loss for the years ended December 31, 2014
and 2013
| | - | -----------------------------------------------------------------------------------------------------------

| | · | Consolidated Statements of Changes in Stockholders’ Equity/(Deficiency) at December 31, 2014
| | - | --------------------------------------------------------------------------------------------

| | · | Consolidated Statements of Cash Flows for the Years Ended December 31, 2014 and 2013
| | - | ------------------------------------------------------------------------------------

| | · | Notes to Consolidated Financial Statements
| | - | ------------------------------------------



(b)       	Exhibits.



|Exhibit
        Number | Description                                                                                                                                                                                                                                                                                                                                                
|---------------------- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|2.1                    | Agreement and Plan of Merger and Reorganization, dated as of July 31, 2014, by and among the Company, Acquisition Sub and Enumeral Biomedical Corp. (Incorporated by reference to Exhibit 2.1 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).
|3.1                    | Amended and Restated Certificate of Incorporation of the Company. (Incorporated by reference to Exhibit 3.1 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                                  
|3.2                    | Amended and Restated By-Laws of the Registrant. (Incorporated by reference to Exhibit 3.2 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                                                    
|3.3                    | Certificate of Merger of Enumeral Biomedical Corp., with and into Acquisition Sub, filed July 31, 2014. (Incorporated by reference to Exhibit 3.3 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                            





28















|Exhibit
        Number | Description                                                                                                                                                                                                                                                                                                                                                                          
|---------------------- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|10.1                   | Split-Off Agreement, dated as of July 31, 2014, by and among Enumeral Biomedical Holdings, Inc., Cerulean Operating Corp. and Olesya Didenko. (Incorporated by reference to Exhibit 10.1 number of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                        
|10.2                   | General Release Agreement, dated as of July 31, 2014, by and among Enumeral Biomedical Holdings, Inc., Cerulean Operating Corp. and Olesya Didenko. (Incorporated by reference to Exhibit 10.2 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                         
|10.3                   | Form of Lock-Up Agreement between Enumeral Biomedical Holdings, Inc. and the officers, directors and shareholders party thereto. (Incorporated by reference to Exhibit 10.3 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                            
|10.4                   | Form of Subscription Agreement for the PPO between Enumeral Biomedical Holdings, Inc. and the investors party thereto. (Incorporated by reference to Exhibit 10.4 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                      
|10.5                   | Form of PPO Warrant for Common Stock of Enumeral Biomedical Holdings, Inc. (Incorporated by reference to Exhibit 10.5 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                                                  
|10.6                   | Placement Agency Agreement, dated July 3, 2014, between Enumeral Biomedical Holdings, Inc. and EDI Financial, Inc., as amended by Amendment No. 1 dated as of July 21, 2014. (Incorporated by reference to Exhibit 10.6 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).
|10.7                   | Placement Agency Agreement, dated July 25, 2014, between Enumeral Biomedical Holdings, Inc. and Katalyst Securities LLC. (Incorporated by reference to Exhibit 10.7 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                    
|10.8                   | Form of Agent Warrant in the PPO for Common Stock of Enumeral Biomedical Holdings, Inc. (Incorporated by reference to Exhibit 10.8 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                                     
|10.9                   | Form of Registration Rights Agreement for the PPO dated July 31, 2014, among Enumeral Biomedical Holdings, Inc. and the other parties thereto (Incorporated by reference to Exhibit 10.9 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                               
|10.10                  | Voting Agreement dated July 31, 2014, among Enumeral Biomedical Holdings, Inc. and the other parties thereto. (Incorporated by reference to Exhibit 10.10 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                              







29







|Exhibit
        Number | Description                                                                                                                                                                                                                                                                                                                                                                               
|---------------------- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|10.11†                 | The Registrant’s 2014 Equity Incentive Plan (Incorporated by reference to Exhibit 10.11 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                                                                                     
|10.12†                 | Amendment No. 1 to Enumeral Biomedical Holdings, Inc.’s 2014 Equity Incentive Plan, adopted on December 1, 2014 (Incorporated by reference to Exhibit 10.3 of the Form 8-K for the event occurring on December 1, as filed with the Securities and Exchange Commission on December 4, 2014 (SEC File No. 333-185891)).                                                                    
|10.13†                 | Form of Non-Qualified Stock Option Agreement under 2014 Equity Incentive Plan. (Incorporated by reference to Exhibit 10.12 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                                                  
|10.14†                 | Form of Stock Appreciation Right Grant Agreement under 2014 Equity Incentive Plan, (Incorporated by reference to Exhibit 10.13 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                                              
|10.15†                 | Form of Restricted Stock Agreement under 2014 Equity Incentive Plan (Incorporated by reference to Exhibit 10.14 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                                                             
|10.16†                 | Form of Incentive Stock Option Agreement under 2014 Equity Incentive Plan. (Incorporated by reference to Exhibit 10.15 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                                                      
|10.17†                 | Amended and Restated Employment Agreement, dated as of July 21, 2014 between Enumeral Biomedical Corp. and Arthur Tinkelenberg, as assumed by Enumeral Biomedical Holdings, Inc. (Incorporated by reference to Exhibit 10.16 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).
|10.18†                 | Amended and Restated Employment Agreement, dated as of July 21, 2014 between Enumeral Biomedical Corp. and John Rydzewski, as assumed by Enumeral Biomedical Holdings, Inc. (Incorporated by reference to Exhibit 10.17 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).     
|10.19†                 | Employment Agreement, dated as of May 19, 2011 between Enumeral Biomedical Corp. and Derek Brand, as assumed by Enumeral Biomedical Holdings, Inc. (Incorporated by reference to Exhibit 10.18 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                              
|10.20†                 | Scientific Advisory Board Agreement, dated as of September 14, 2014, between Enumeral Biomedical Holdings, Inc. and Barry Buckland, Ph.D. (Incorporated by reference to Exhibit 10.3 of the Form 10-Q for the quarterly period ended September 30, 2014 as filed with the Securities and Exchange Commission on November 14, 2014 (SEC File No. 333-185891)).                             







30







|Exhibit
        Number | Description                                                                                                                                                                                                                                                                                                                                                                                                     
|---------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|10.21                  | Real Estate Lease Agreement, dated as of July 16, 2012, between Enumeral Biomedical Corp. and RB Kendall Fee, LLC (Incorporated by reference to Exhibit 10.19 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                                     
|10.22                  | Indenture of Lease, dated as of November 7, 2014, between King 200 CPD LLC and Enumeral Biomedical Holdings, Inc. (Incorporated by reference to Exhibit 10.1 of the Form 10-Q for the quarterly period ended September 30, 2014 as filed with the Securities and Exchange Commission on November 14, 2014 (SEC File No. 333-185891)).                                                                           
|10.23                  | Form of Replacement Warrant, issued by Enumeral Biomedical Holdings, Inc. to Square 1 Bank pursuant to Loan and Security Agreement between Enumeral Biomedical Corp. and Square 1 Bank, as amended (Incorporated by reference to Exhibit 10.23 of the Form 10-K for the annual period ended December 31, 2014 as filed with the Securities and Exchange Commission on March 19, 2015 (SEC File No. 333-185891)).
|10.24§                 | Exclusive Patent License Agreement, dated as of April 15, 2011, between Enumeral Biomedical Corp. and the Massachusetts Institute of Technology. (Incorporated by reference to Exhibit 10.22 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on October 31, 2014 (SEC File No. 333-185891)).                                                    
|10.25§                 | First Amendment to Exclusive Patent License Agreement, effective as of March 8, 2013, between Enumeral Biomedical Corp. and the Massachusetts Institute of Technology.  (Incorporated by reference to Exhibit 10.23 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on October 31, 2014 (SEC File No. 333-185891)).                             
|10.26                  | Second Amendment to Exclusive Patent License Agreement, effective as of July 16, 2014, between Enumeral Biomedical Corp. and the Massachusetts Institute of Technology. (Incorporated by reference to Exhibit 10.24 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                               
|10.27§                 | Contract Research Agreement, dated as of February 28, 2012, between Enumeral Biomedical Corp. and Crucell Holland B.V. (Incorporated by reference to Exhibit 10.25 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on October 31, 2014 (SEC File No. 333-185891)).                                                                              
|10.28§                 | 1st Amendment to Contract Research Agreement, dated as of March 22, 2013, between Enumeral Biomedical Corp. and Crucell Holland B.V. (Incorporated by reference to Exhibit 10.26 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                  
|10.29§                 | Master Service Provider Agreement, dated as of March 14, 2012, between Enumeral Biomedical Corp. and Anthrogenesis Corporation D/B/A Celgene Cellular Therapeutics. (Incorporated by reference to Exhibit 10.27 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on October 31, 2014 (SEC File No. 333-185891)).                                 









31







|Exhibit
        Number | Description                                                                                                                                                                                                                                                                                                                                                                                  
|---------------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|10.30§                 | Change Order, dated as of December 16, 2013, between Enumeral Biomedical Corp. and Celgene Cellular Therapeutics. (Incorporated by reference to Exhibit 10.28 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                  
|10.31§                 | Research Agreement, dated as of June 18, 2012, between Enumeral Biomedical Corp. and sanofi-aventis U.S. Inc. (Incorporated by reference to Exhibit 10.29 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on October 31, 2014 (SEC File No. 333-185891)).                                                                    
|10.32§                 | Services Agreement, dated as of October 8, 2013, between Enumeral Biomedical Corp. and Novartis Pharma AG. (Incorporated by reference to Exhibit 10.30 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on October 31, 2014 (SEC File No. 333-185891)).                                                                       
|10.33§                 | Agreement, dated as of March 21, 2013, between Enumeral Biomedical Corp. and Fikst. (Incorporated by reference to Exhibit 10.31 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                                                
|10.34§                 | Award/Contract, dated as of September 17, 2012, between Enumeral Biomedical Corp. and National Cancer Institute. (Incorporated by reference to Exhibit 10.32 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                   
|10.35§                 | Award/Contract, dated as of September 10, 2014, between Enumeral Biomedical Corp. and National Cancer Institute (Incorporated by reference to Exhibit 10.2 of the Form 10-Q for the quarterly period ended September 30, 2014 as filed with the Securities and Exchange Commission on November 14, 2014 (SEC File No. 333-185891)).                                                          
|10.36§                 | Study Agreement, dated as of December 17, 2014, between Enumeral Biomedical Holdings, Inc. and Merck Sharp & Dohme Corp. (Incorporated by reference to Exhibit 10.36 of the Form 10-K for the annual period ended December 31, 2014 as filed with the Securities and Exchange Commission on March 19, 2015 (SEC File No. 333-185891)).                                                       
|10.37                  | Form of Replacement Warrant issued by Enumeral Biomedical Holdings, Inc. to holders of warrants of Enumeral Biomedical Corp issued in connection with the Bridge Notes offering (Incorporated by reference to Exhibit 10.37 of the Form 10-K for the annual period ended December 31, 2014 as filed with the Securities and Exchange Commission on March 19, 2015 (SEC File No. 333-185891)).
|10.38†                 | Offer Letter dated July 25, 2014, between Enumeral Biomedical Corp. and Kevin G. Sarney. (Incorporated by reference to Exhibit 10.44 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                                           
|10.39                  | Form of Indemnification Agreement between Enumeral Biomedical Holdings, Inc. and each of its directors and officers (Incorporated by reference to Exhibit 10.45 of the Form 8-K/A for the event occurring on July 31, 2014 as filed with the Securities and Exchange Commission on August 8, 2014 (SEC File No. 333-185891)).                                                                





32







|Exhibit
        Number | Description                                                                                                                                                                                                                                                  
|---------------------- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|21                     | Subsidiaries of Enumeral Biomedical Holdings, Inc. (Incorporated by reference to Exhibit 21 of the Form 10-K for the annual period ended December 31, 2014 as filed with the Securities and Exchange Commission on March 19, 2015 (SEC File No. 333-185891)).
|31.1*                  | Principal Executive Officer Certification required by Rule 13a-14(a) or Rule 15d-14(a) of the Securities Exchange Act of 1934, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                                         
|31.2*                  | Principal Financial and Accounting Officer Certification required by Rule 13a-14(a) or Rule 15d-14(a) of the Securities Exchange Act of 1934, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                          
|101 **                 | Interactive Data Files of Financial Statements and Notes.                                                                                                                                                                                                    
|101.INS **             | XBRL Instance Document.                                                                                                                                                                                                                                      
|101.SCH**              | XBRL Taxonomy Extension Schema Document.                                                                                                                                                                                                                     
|101.CAL**              | XBRL Calculation Linkbase Document.                                                                                                                                                                                                                          
|101.DEF**              | XBRL Taxonomy Extension Definition Linkbase Document.                                                                                                                                                                                                        
|101.LAB**              | XBRL Label Linkbase Document.                                                                                                                                                                                                                                
|101.PRE**              | XBRL Taxonomy Presentation Linkbase Document.                                                                                                                                                                                                                



*	Filed herewith.



**	Previously furnished with the Form
10-K for the annual period ended December 31, 2014 as filed with the Securities and Exchange Commission on March 19, 2015 (SEC
File No. 333-185891).



†	Management contract or compensatory
plan or arrangement.



| | § | Confidential treatment requested as to certain portions, which portions have been filed separately
with the Securities and Exchange Commission.
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------







33









SIGNATURES



Pursuant to the requirements
of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf
by the undersigned, thereunto duly authorized.



|               | ENUMERAL BIOMEDICAL HOLDINGS, INC.
|-------------- | ----------------------------------
|               |                                   
|April 28, 2015 | By:                               
|               | Name:                             
|               | Title:                            



Pursuant to the requirements
of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant
in the capacities and on the dates indicated.



|Name                                        |  | Positions                                                                                                                                |  | Date          
|------------------------------------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------- |  | --------------
|                                            |  |                                                                                                                                          |  |               
|/s/ John J. Rydzewski                       |  | Director and Executive Chairman of the Board                                                                                             |  | April 28, 2015
|John J. Rydzewski                           |  |                                                                                                                                          |  |               
|                                            |  |                                                                                                                                          |  |               
|/s/ Arthur H. Tinkelenberg, Ph.D.           |  | President, Chief Executive Officer and Director
        (principal executive officer)                                                    |  | April 28, 2015
|Arthur H. Tinkelenberg, Ph.D.               |  |                                                                                                                                          | 
|                                            |  |                                                                                                                                          |  |               
|/s/ Barry Buckland, Ph.D.                   |  | Director                                                                                                                                 |  | April 28, 2015
|Barry Buckland, Ph.D.                       |  |                                                                                                                                          | 
|                                            |  |                                                                                                                                          |  |               
|/s/ Allan Rothstein                         |  | Director                                                                                                                                 |  | April 28, 2015
|Allan Rothstein                             |  |                                                                                                                                          |  |               
|                                            |  |                                                                                                                                          |  |               
|/s/ Paul J. Sekhri                          |  | Director                                                                                                                                 |  | April 28, 2015
|Paul J. Sekhri                              |  |                                                                                                                                          |  |               
|                                            |  |                                                                                                                                          |  |               
|/s/ Robert L. Van Nostrand                  |  | Director                                                                                                                                 |  | April 28, 2015
|Robert L. Van Nostrand                      |  |                                                                                                                                          |  |               
|                                            |  |                                                                                                                                          |  |               
|/s/ Daniel B. Wolfe, Ph.D.                  |  | Director                                                                                                                                 |  | April 28, 2015
|Daniel B. Wolfe, Ph.D.                      |  |                                                                                                                                          |  |               
|                                            |  |                                                                                                                                          |  |               
|/s/ Kevin G. Sarney
        Kevin G. Sarney |  | Vice President of Finance, Chief Accounting Officer and Treasurer
        (principal financial officer and principal accounting officer) |  | April 28, 2015









34







EXHIBIT INDEX



The Company is filing as part of this Annual
Report on Form 10-K the following exhibits:



|Exhibit Number | Description                                                                                                                                                                                         
|-------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|31.1           | Principal Executive Officer Certification required by Rule 13a-14(a) or Rule 15d-14(a) of the Securities Exchange Act of 1934, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
|31.2           | Principal Financial Officer Certification required by Rule 13a-14(a) or Rule 15d-14(a) of the Securities Exchange Act of 1934, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

















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