### Clcthodim Dietary Exposure and Risk Assessment DP Nu m ber: 431223

PC Code: 

### 121011



## UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D

. C. 20460

OFFICE OF CHEMICAL SAF ET Y AND POLLUTION PREVENTION



## MEMORANDUM

DAT E: 

## 01/ 1 9116

SUBJECT: C l et h odi m: 

## Acute and Chronic Aggregate Dietary ( F ood and Drinking Water) Exposure an d Ri sk Assess m e nts fo r New Uses on Stevia; Pom e Fruit C rop Group 1 1-1 

## O ; Stone F ruit Crop Group 12-12; a nd Cr op Group / Subgroup Expa nsi o n s fo r Onion, Bulb Subgroup 3

- 07 A; Fruitin g Vegetables Cro p Group 8-1 

## O; Low g r ow in g S ub g roup 1 3-0 7G

, exce pt
Cra n berry; Rapeseed Subgroup 20A, except Flax Seed; Sun fl ower S u bgrou p 208; and Cotto n see d Subgroup 20C.

PC Co de: 

## 121011

D ecis ion No.: 

## 497978

P et iti o n No. : 

## 4E8334 DP Barcode: 

## D431223

Re g i strat ion Nos.: 

## 59639

- 3

, 59639- 1 32
Regulatory Act i o n: 

## Sect i on 3

Ri s k Assessme nt T y pe: 

## Sing l e Chemical/ Agg re ga t e Case No.: 

## NA

TXR No.: 

## NA CAS No.: 

## 99129-21-2

40 CF R: § 

## 180.4 5 8 MRID No

. : 

## NA

FROM :

THROUGH:

TO : 

## Meheret Negussie, C hemi s t 

# /ieiierd**~Cl"V-#<'e.** Ri sk Assessmen t Branch Ill (RAB3)

H ea l th Effects Di visio n (HE D ) (7509P)

S h eila Pip er, Sen i or

# emis**~** Don a ld Wilbur

, S e nior Ch e mist

# \I**~** Dietary Exposu r e Sc i ence Adv i sory

# Cou~~C)

# Ch**ri tin** **ae n~lin** **ge ,**  Br a nch C hi ef 

# ,iJ 

# I/ Cf&

RAB3/HED (7509 P ) 

# {/7 / /

.._

Laura No ll en, Bi o l og i st/ Ri s k Assesso r RA83/HED (7509 P)

a nd
Barbara Madden/Sidne y Jackson

, RM #5

Ri sk Int egratio n , Minor Use, a nd E m e r ge n cy R es p o ns e Branch

R

eg i s tr a tion Division (7505 P )

Pa ge I of23

### Clethodim Dietary Exposure and Ri s k Asse ss ment DP Number: 43 12 23
PC Code: 121011



## I. Exec uti ve S umm ary

Acute and chronic aggregate dietary (food and drinking water) exposure and ri s k

assessments were conducted using the Dietary Exposure Eva l uati on Model sof tware with

the Food Commod it y Intake Database (DEEM-FCID) Version 3.16. Thi s software uses 2003-2008 food consumption data from the U.S. Dep a rtment of Agriculture's (USDA ' s)

National H ealt h and Nutrition Examination Survey

, What We Eat in America, (NHANES / WWEIA). The analyses were conducted in s upport of n ew u ses on s t ev i a;

po me fruit crop croup 11

- 10: stone fruit crop group 12-12 ; and crop group / subgroup expansions for onion, bulb subgroup 3-07 A; fruiting vegetab l es crop group 8-10 ; Low growing s ubgroup 13-070

, except cranber r y; rapeseed subgroup 20A, except flax seed;

and cottonseed subgroup 20C. Thi s memorandum was reviewed by two peer reviewer s of the D ES AC

, per DESAC SO P 2012. 1

.

Acute and Clu-onic Dietary (Food and Drinking Water) Exposure Results and

Characterization

Unrefined acute and chronic dietar y analyses were conducted. The assumptions of the

di e tary assessment included tolerance levels for all commodities and l 00 % crop treated (CT). DEEM version 7.81 default proce ss ing factors were assumed except for where

tol erances were established for processed commoditie s

. Estimated drinking water
concentrations (EDWCs) were incorporated directly into th e dietary assessment from ground water estimates obtained u s ing the Pe sticide Root Zo n e Model for Ground Water ( PRZM- GW) model provided by th e Environmental Fate and Effects Di v i sio n (E FED ).

The acute di etary risk assessment s how s that the acute dietary risk est im a t es are below

H ED ' s le v el of concern (LOC) (i.e., < 100 % of the acute population adjusted do se (aPAO)). For the general U.S. population

, th e exposure for food and drinkin g water
utilized 10 % of the aPAD. The acute dietary ri s k estimate for the highe s t reported exposed population subgroup, all infant s (< l yea r old), utili ze d 29 % of the aPAD at th e 95 111 

## percentile.

The chronic dietary risk assessment s h ows that th e chronic dietary risk est imat es are below H E D 's LOC ( i.e., < 100 % of the chronic population adjusted dose (c PAD) )

. For

the genera l U.S. population

, the exposure for food and drinkin g water utili ze d 1 2% of the

cP AD. The chro ni c dietary risk estimate for the highe s t reported exposed population subgroup

, all infants (< l year old)

, utili zed 30% of the cPAD.

Ca ncer Dietary (rood and Drinking Wat e r) Exposure

Clcthodim has been classified as ''No t likely to be Carcinogenic to Humans " ba se d no treatment-related in c r ease in tumor incidence in rat and m ouse carcinogenicity studies.

Therefore

, cancer ri sk was not assessed.

Page 2 of23

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 3 of 23 

## Introduction

Dietary risk assessment incorporates both exposure and toxicity for any given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreas onable adverse health effects). This dose is referred to as the population

- adjusted dose (PAD). The PAD is equivalent to the point of departure (POD); e.g. no observed adverse effect level (NOAEL), lowest observed adverse effect level (LOAEL), etc.) div ided by the required uncertainty or safety factors.

For non

- cancer chronic exposures, HED is concerned when estimated dietary risk
exceeds 100% of the cPAD. References which discuss chronic risk assessments in more detail are available on the EPA/pestici des web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21

- JUN

- 2000, web link: http://www.epa.gov/fedrgstr/EPA

- PEST/2000/July/Day

- 12/6061.pdf or see SOP 99.6 (20

- AUG

- 1999).

The most recent dietary risk assessment for clethodim was conducted by Nancy Dodd (DP# D412296

, 11/13/2013 ).

II. Residue Information

Permanent tolerances have been established in 40 CFR §180.458 for the combined residues of clethodim and its metabolites containing the 5

- (2

- ethylthiopropyl)cyclohexene

- 3

- one and 5

- (2

- ethylthiopropyl)

- 5

- hydroxycyclohexene

- 3

- one moieties and their sulphoxides and sulphones, expressed as clethodim in/on various raw agricultura l commodities ranging from 0.2 ppm in livestock commodities to 20 ppm in clover, hay. The residues of concern for tolerance expression and risk assessment are
the same.

T able 1 presents the residue values for the proposed uses. The complete details o f HED recommendations are presented in the s ummary document (DP# D42 5763

, M. Negussie,
01/13/2016 )

.

In general, pesticide residues would not be expected to be found in fish unless the pesticide bioaccumulates or has an aquatic use. To determine whether or not residues are present in fish, HED now routinely checks PDP monitoring data regardless of the pesticide’s uses and physicochemical properties. The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, and 2010 . PD P analyzed
residues in salmon in 2013. H owever, the samples were not analyzed for clethodim.

Residue Data used for Acute and Chronic Assessment:

Unrefined acute and chronic dietary analyses were conducted . T he assumptions of the dietary assessment included t olerance levels for all commodities and 100% CT.

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 4 of 23 

## DEEM default processing factors were used when available except for potato, dry (granules/flakes) and sesame oil, for which either a tolerance was established or an empirical processing factor wa s available. A 2.0 ppm tolerance was established on potato granules/flakes (DP#’s 240302 and 254018, M. Xue, 09/07/2000). A sesame oil processing factor of 1.4x was recommended by ARIA (D. Rate, DP#334913, 02/09/2007).

A processing study (J. Stokes, D P#333329, 09/09/2007) indicated that no separate tolerances or processing factors are required for the following field corn processed commodities: flour, meal, starch, grits, and refined oil. Stevia is not a commodity with reported consumption in DEEM. A dditionally, based on previous decisions made by the
ChemSAC (09/11/ 2013), we do not expect there to be residues in stevia ( 

## Rebaudioside A powder ) , and thus exposure is expected to be negligible.

Table 1. Tolerance Summary for Clethodim.
Commodity Proposed
Tolerance (ppm) Recommended

Tolerance (ppm) Comments; Correct Commodity

Definition

Onion, bulb Subgroup 3

- 07A 0.2 0. 5 0 Onion, bulb, subgroup 3

- 07A
Fruiting Vegetable s G roup 0 8

- 10 1.0 1.0 Vegetable

, f ruiting, Group 8

- 10

Pome Fruit G roup 1 1

- 10 0.2 0.2 0 Fruit, pome, group 11

- 10

Stone Fruit Group 12

- 12 0.2 0.2 0 Fruit, stone, group 12

- 12

L ow G rowing Berry S ubgroup
13

- 07G , except Cranberry 3.0 3.0 Berry, low growing, subgroup 13

- 07G

, except cranberry
Rapeseed subgroup 20A , except flax 0.5 0.5 0 Rapeseed subgroup 20A

, except flax
seed
Sunflower subgroup 20B 5.0 5.0
Cotton seed subgroup 20C 1.0 1.0 Cotton seed subgroup 20C

Stevia 12.0 12 Stevia, dried leaves



## III. Percent Crop Treated Information

100% CT was assumed for all crops.

IV. Drinking Water Data

The drinking water residues used in the acute and chronic dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) in the following
memorandum: “ Clethodim: Drinking Water Exposure Assessment for Registration
Review ” ( G. Orrick

, DP# D425767, 03/31/2015 and D P#412704

, 6/24/13 ) and incorporated directly into this dietary assessment. Water residues were incorporated in
the DEEM

- FCID into the food categories “wa ter, direct, all sources” and “water, indirect,
all sources.”

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 5 of 23 

## B ased on the proposed application rates and the environmental fate properties of clethodim, surface and ground water contamination may occur from clethodim as well as
its sulfoxide and sulfo ne degradates. The risk of water contamination is primarily associated with clethodim sulfone and clethodim sulfoxide rather than parent clethodim based on greater persistence and mobility of these degradates. Thus, the assessment s w ere based on the total toxic residue rather than parent only.

The maximum screening

- level acute and chronic EDWCs (1,43 0 and 1,150 μg/L, respectively) which are used in the dietary assessment are based on the maximum use pattern for clethodim (which includes non

- cropped areas, fallow ground, and alfalfa), which includes a maximum annual application rate of 4.5 lbs a.i./A. The EDWCs are
estimated with PRZM

- GW to occur in an area of Wisconsin that is vulnerable to ground
water contamination. These EDWCs are 4 3

- 53x greater than screening

- level EDWCs for ground water from Screening Concentration In Ground Water (SCI

- GROW ) and 4

- 8x greater than screening

- level EDWCs for surface water from FIRST (FQPA Index Reservoir Screening Tool) (Table 2 ). The variance with S CI

- GROW may be due, in part, to 1) PRZM

- GW being mechanistic, the SCI

- GROW is empirical, and 2) differences in modeling assumptions such as the duration of the modeling scenario.

Table 2 . Screening

- Level ROC EDWCs for Clethodim Uses 1



### Source (Tier: Model) Use Site (Max. Annual App. Rate) Acute (μg/L) Chronic

(μg/L)

Surface water (Tier I: FIRST) Non

- cropped (4.5 lbs a.i./A) 330 137
Ground water (Tier I: PRZM

- GW) Non

- cropped (4.5 lbs a.i./A) 1,430 1,150
Ground water (Tier I: SCI

- GROW) Non

- cropped (4.5 lbs a.i./A) ≤27

1 

### Maximum values in bold.



## The models and their descriptions are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/

.

V. DEEM

- FCID Program and Consumption Information

Clethodim acute and chronic dietary exposure assessment s were conducted using the

DEEM

- FCID, Version 3.16, which incorporates 2003

- 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported cons umption of more than 20,000 individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA

- defined food commodities (e.g., apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S , baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. However, for acute exposure a ssessment, consumption data are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2,

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 6 of 23 

## children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 years old.

For chronic dietary exposure assessment, an e stimate of the residue level in each food or
food

- form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting re sidue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

V I

. Toxicological Information

The toxicity endpoints pertinent for human dietary risk assessment are summarized in
Table 3

.

Table 3

. Summary of Toxicological Doses and Endpoints fo r Clethodim for Use in Dietary Exposure Risk Assessments.

Exposure/
Scenario Point of

Departure Uncertainty/

FQPA Safety

Factors RfD, PAD, Level

of Concern for
Risk Assessment Study and Toxicological
Effects

Acute Dietary (All Populations) NOAEL

=100 mg/kg/day UF A 

### = 10X

UF H 

### = 10X FQPA SF =

1X Acute RfD = 1

mg/kg/day

aPAD= 1 mg/kg/day Acute neurotoxicity studies

rats LOAEL =1000 mg/kg based
on clinical observation from two acute neurotoxicity studies (one study was
conducted in 2006 and the current study, completed in 2012). The clinical
observation included decreased spontaneous activity, ruffled fur, head tilt, and hunched posture

.

Chronic Dietary (All Populations) NOAEL =

30 mg/kg/day UF A 

### = 10X

UF H 

### = 10X FQPA SF =

1X C hronic RfD =

0.3mg/kg/day

cPAD = 0.3 mg/kg/day Carcinogenicity study

- mice

LOAEL=150 mg/kg/day based on reduced survival;
decreased red cell mass; and
increased incidences of bile duct hyperplasia, of pigmentation of the liver, and of foci of amphophilic macrophages in the lung.

Cancer (oral, dermal, inhalation) Clethodim is classified as "Not Likely" to be carcinogenic based no treatment

- related

increase in tumor incidence in rat and mouse carcinogenicity studies.

Point of Departure (POD) = A data poin t or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A 

### = extrapolation from animal to human

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 7 of 23 (interspecies). UF H 

### = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic).
RfD = reference dose.



## VI I

. Results/Discussion

Results of Acute and Chronic Dietary (Food and Drinking Water) Exposure Analysis

As stated above, for acute and chronic assessments, HED is concerned when dietary risk
exceeds 100% of the PAD. The DEEM

- FCID analyses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 4 are for the general U.S. Population, all infants (<1 year old), child ren 1

- 2, children 3

- 5,
children 6

- 12, youth 13

- 19, females 13

- 4 9, adults 20

- 49, and adults 50

- 99 years.

The acute dietary exposure for food and drinking water utilized 1 0 % of the aPAD for the general U.S. population. The acute dietary exposure for the highest reported exposed population subgroup, all infants (<1 year old), utilized 2 9 % of the a PAD at the 95 th 

## percentile

.

The chronic dietary exposure for food and drinki ng water utilized 1 2 % of the cPAD for
the general U.S. population. The chronic dietary exposure for the highest reported exposed population subgroup, all in fants (<1 year old), utilized 30 % of the cPAD.

The results of the acute and chronic dietary exposure analys e s are reported in T able 4
below.

Table 4

. Summary of Dietary (Food and Drinking Water ) Exposure and Risk for Clethodim

.

Population Subgroup Acute Dietary
95th% percentile Chronic Dietary

Dietary (mg/kg/day) % aPAD Dietary Exposure (mg/kg/day) % cPAD

General U.S. Population 0.10 2 035 10 0.037 592 1 2

All Infants (< 1 year old) 0.28 6 813 2 9 0.0 90304 30

Children 1

- 2 years old 0.17 7502 18 0.07 4277 2 5

Children 3

- 5 years old 0.15 7066 1 6 0.06 1470 20

Children 6

- 12 years old 0.105 444 10 0.04 0639 14

Youth 13

- 19 years old 0.08 0662 8. 1 0.028 696 9.6

Adults 20

- 49 years old 0.094 225 9. 4 0.03 4796 12

Adults 50

- 99 years old 0.08 4808 8. 5 0.034 303 11

Females 13

- 49 years old 0.09 4612 9.5 0.034 543 12

aPAD= 1 mkd; cPAD= 0.3 mkd; Highest Exposure values are bold ed

.

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 8 of 23 

## VII I

. Characterization of Inputs/Outputs

The acute and chronic dietary exposure assessment is un refined, i.e., based on the

a ssumption of tolerance

- level residues for all commodities and 100% CT

. R efinement to the analyses cou ld be made through the use of anticipated residues

, %CT data , empirical processing factors, and monitoring data . Since risk estimates are below HED’s level of

concern, a refined analysis is not needed at this time.

I X

. Conclusions

The acute and ch ronic dietary a nalyses demonstrate that the exposure from the existing
and requested uses for clethodim will not result in dietary risk estimates that exceed

HED ’s level of concern for any of the regulated population subgroups, including those comprised o f infants and children.

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 9 of 23 

## X. List of Attachments

Attachment 1: Acute Food and Water Residue Input File
Attachment 2: Acute Food and Water Results File
Attachment 3 : Chronic Food and Water Residue Input File
Attachment 4 : Chronic Food and Water Results File

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 10 of 23 

## Attachment 1 : Acute Food and Water Residue Input File

Filename: C: \ Users \ mnegussi \ Documents \ DEEM Version 3.16 \ Clethodim \ New

folder \ AcuteClethodim2016.R08

Chemical: Clethodim RfD(Chronic): 0.3 mg/kg bw/day NOEL(Chronic): 30 mg/kg bw/day RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day Date created/last modified: 01

- 13

- 2016/12:30:46 Program ver. 3.16, 03

- 08

- d

Com ment: New Acute Reference Dose; New uses

- apple, pear, cherry, plum and crop group expansion

--------------------- -------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------ ------------- ---------- ------ ------ ------- 0101050000 1AB Beet, garden, roots 1.000000 1.000 1.000 0101050001 1AB Beet, garden, roots

- babyfood 1.000000 1.000 1.000 0101052000 1A Beet, sugar 0 .200000 1.000 1.000 0101052001 1A Beet, sugar

- babyfood 0.200000 1.000 1.000 0101053000 1A Beet, sugar, molasses 1.000000 1.000 1.000 0101053001 1A Beet, sugar, molasses

- babyfood 1.000000 1.000 1.000

0101067000 1AB Burdock 1.000000 1.000 1.000

0101078000 1AB Carrot 1.000000 1.000 1.000

0101078001 1AB Carrot

- babyfood 1.000000 1.000 1.000 0101079000 1AB Carrot, juice 1.000000 1.000 1.000

0101084000 1AB Celeriac 1.000000 1.000 1.000 0101100000 1AB Chicory, roots 1.000000 1.000 1.000 0101168000 1AB Ginseng, dried 1.000000 1.000 1.000

0101190000 1AB Horseradish 1.000000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 1.000000 1.000 1.000 0101251000 1AB Parsnip 1.000000 1.000 1.000 0101251001 1AB Parsnip

- babyfood 1.000000 1.000 1.000 0101314000 1AB Radish, roots 1.000000 1.000 1.000 0101316000 1AB Radish, Oriental, roots 1.000000 1.000 1.000 0101327000 1AB Rutabaga 1.000000 1.000 1.000 0101331000 1AB Salsify, roots 1.000000 1.000 1.000 0101388000 1AB Turnip, roots 1.000000 1.000 1.000

0103015000 1CD Arrowro ot, flour 1.000000 1.000 1.000 0103015001 1CD Arrowroot, flour

- babyfood 1.000000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 1.000000 1.000 1.000

0103082000 1CD Cassava 1.000000 1.000 1.000

0103082001 1CD Cassava

- babyfood 1.000000 1.000 1.000 0103139000 1CD Dasheen, corm 1.000000 1.000 1.000 0103166000 1CD Ginger 1.000000 1.000 1.00 0 0103166001 1CD Ginger

- babyfood 1.000000 1.000 1.000 0103167000 1CD Ginger, dried 1.000000 1.000 1.000 0103296000 1C Potato, chips 1.000000 1.000 1.000

0103297000 1C Potat o, dry (granules/ flakes) 2.000000 1.000 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 2.000000 1.000 1.000 0103298000 1C Potato, flour 1.000000 6.500 1.000 0103298001 1C Potato, flour

- babyfood 1.000000 6.500 1.000 0103299000 1C Potato, tuber, w/peel 1.000000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 1.000000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 1.000000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 1.000000 1.000 1.000 0103366000 1CD Sweet potato 1.000000 1.000 1.000 0103366001 1CD Sweet pot ato

- babyfood 1.000000 1.000 1.000 0103371000 1CD Tanier, corm 1.000000 1.000 1.000

0103387000 1CD Turmeric 1.000000 1.000 1.000 0103406000 1CD Yam, true 1.000000 1.000 1.000

0103407000 1CD Yam bean 1.000000 1.000 1.000 0200315000 2 Radish, tops 0.700000 1.000 1.000 0200317000 2 Radish, Oriental, tops 0.700000 1.000 1.000 0200332000 2 Salsify, tops 0.700000 1.000 1.000 0301165000 3A Garlic, bulb 0. 5 00000 1.000 1.000 D42576

Full comment: D425763

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 11 of 23 0301165001 3A Garlic, bulb

- babyfood 0. 5 00000 1.000 1.000 0301237000 3A Onion, bulb 0. 5 00000 1.000 1.000 0301237001 3A Onion, bulb

- babyfood 0. 5 00000 1.000 1.000 0301238000 3A Onion, bulb, dried 0. 5 00000 9.000 1.000

03012380 01 3A Onion, bulb, dried

- babyfood 0. 5 00000 9.000 1.000 0301338000 3A Shallot, bulb 0. 5 00000 1.000 1.000 0302103000 3B Chive, fresh leaves 12.000000 1.000 1.000 4E6836 0302239000 3B Onion, gree n 2.000000 1.000 1.000 0401005000 4A Amaranth, leafy 2.000000 1.000 1.000 5E6978 0401018000 4A Arugula 2.000000 1.000 1.000 5E6978 0401104000 4A Chrysanthemum, garland 2.000000 1.000 1.000 5E6978 0401133000 4A Cress, garden 2.000000 1.000 1.000 5E6978 0401134000 4A Cress, upland 2.000000 1.000 1.000 5E6978 0401138000 4A Dandelion, leaves 2.000000 1.000 1.000 5E6978

0401150000 4A Endive 2.000000 1.000 1.000 5E6978 0401204000 4A Lettuce, head 2.000000 1.000 1.000 5E6978 0401205000 4A Lettuce, leaf 2.000000 1.000 1.000 5E6978 0401248000 4A Parsley, leaves 2.000000 1.000 1.000 5E6978

0401313000 4A Radicchio 2.000000 1.000 1.000 5E6978 0401355000 4A Spinach 2.00000 0 1.000 1.000 5E6978 0401355001 4A Spinach

- babyfood 2.000000 1.000 1.000 5E6978

0402076000 4B Cardoon 0.600000 1.000 1.000 0402085000 4B Celery 0.600000 1.000 1. 000 0402085001 4B Celery

- babyfood 0.600000 1.000 1.000 0402086000 4B Celery, juice 0.600000 1.000 1.000

0402087000 4B Celtuce 0.600000 1.000 1.000

0402152000 4B Fen nel, Florence 0.600000 1.000 1.000

0402322000 4B Rhubarb 0.600000 1.000 1.000

0402367000 4B Swiss chard 0.600000 1.000 1.000

0501061000 5A Broccoli 3.000000 1.000 1.000

0501061001 5A Broccoli

- babyfood 3.000000 1.000 1.000 0501062000 5A Broccoli, Chinese 3.000000 1.000 1.000 0501064000 5A Brussels sprouts 3.000000 1.000 1.000 0501069000 5A Cabbage 3.000000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 3.000000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 3.000000 1.000 1.000

0501083000 5A C auliflower 3.000000 1.000 1.000

0501196000 5A Kohlrabi 3.000000 1.000 1.000

0502063000 5B Broccoli raab 3.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 3.000000 1.000 1.000

0502117000 5B Collards 3.000000 1.000 1.000

0502194000 5B Kale 3.000000 1.000 1.000 0502229000 5B Mustard greens 3.000000 1.000 1.000 0502318000 5B Rape greens 3.000000 1.000 1.000 0502389000 5B Turnip, greens 3.000000 1.000 1.000 0600347000 6 Soybean, seed 10.000000 1.000 1.000 0600349000 6 Soybean, soy milk 10.000000 1.000 1.000 0600349001 6 Soybean, soy milk

- babyfood or in 10.000000 1.000 1.000 0600350000 6 Soybean, oil 10.000000 1.000 1.000 0600350001 6 Soybean, oil

- babyfood 10.000000 1.000 1.000 0601043000 6A Bean, snap, succulent 3.500000 1.000 1.000 4F6895

Full comment: 4F6895 0601043001 6A Bean, snap, succulent

- babyfood 3.500000 1.000 1.000 4F6895

Full comment: 4F6895 0601257000 6A Pea, edible podded, succulent 3.500000 1.000 1.000 4F6895 0601349500 6AB Soybean, vegetable 10.000000 1.000 1.000 0602031000 6B Bean, broad, succulent 3.500000 1.00 0 1.000 4F6895 0602033000 6B Bean, cowpea, succulent 3.500000 1.000 1.000 4F6895 0602037000 6B Bean, lima, succulent 3.500000 1.000 1.000 4F6895 0602255000 6B Pea, succulent 3.500000 1.000 1.00 0 4F6895 0602255001 6B Pea, succulent

- babyfood 3.500000 1.000 1.000 4F6895 0602259000 6B Pea, pigeon, succulent 3.500000 1.000 1.000 4F6895 0603030000 6C Bean, black, seed 3.500000 1.000 1.000 4F68 95 0603032000 6C Bean, broad, seed 3.500000 1.000 1.000 4F6895 0603034000 6C Bean, cowpea, seed 3.500000 1.000 1.000 4F6895 0603035000 6C Bean, great northern, seed 3.500000 1.000 1.000 4F6895

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 12 of 23 0603 036000 6C Bean, kidney, seed 3.500000 1.000 1.000 4F6895 0603038000 6C Bean, lima, seed 3.500000 1.000 1.000 4F6895 0603039000 6C Bean, mung, seed 3.500000 1.000 1.000 4F6895

0603040000 6C Bean, navy, seed 3.500000 1.000 1.000 4F6895 0603041000 6C Bean, pink, seed 3.500000 1.000 1.000 4F6895 0603042000 6C Bean, pinto, seed 3.500000 1.000 1.000 4F6895

0603098000 6C Ch ickpea, seed 3.500000 1.000 1.000 4F6895 0603098001 6C Chickpea, seed

- babyfood 3.500000 1.000 1.000 4F6895 0603099000 6C Chickpea, flour 3.500000 1.000 1.000 4F6895 0603182000 6C Guar, seed 3.500000 1.000 1.000 4F6895 0603182001 6C Guar, seed

- babyfood 3.500000 1.000 1.000 4F6895 0603203000 6C Lentil, seed 3.500000 1.000 1.000 4F6895 0603256000 6C Pea, dry 3.500000 1.000 1.000 4F6895 0603256001 6C Pea, dry

- babyfood 3.500000 1.000 1.000 4F6895 0603258000 6C Pea, pigeon, seed 3.500000 1.000 1.000 4F6895 0603348000 6C Soybean, flour 10.000000 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 10.000000 1.000 1.000

0801374000 8A Tomatillo 1.000000 1.000 1.000

0801375000 8A Tomato 1.000000 1.000 1.000

0801375001 8A Tomato

- babyfood 1.000000 1.000 1.000 0801376000 8A Tomato, paste 1.000000 5.400 1.000 previo

Full comment: previous tolerance expired 4/30/03

0801376001 8A Tom ato, paste

- babyfood 1.000000 5.400 1.000 previo

Full comment: previous tolerance expired 4/30/03 0801377000 8A Tomato, puree 1.000000 3.300 1.000 previo

Full comment: previous tolerance exp ired 4/30/03 0801377001 8A Tomato, puree

- babyfood 1.000000 3.300 1.000 previo

Full comment: previous tolerance expired 4/30/03 0801378000 8A Tomato, dried 1.000000 14.300 1.000

0801378001 8A Tomato , dried

- babyfood 1.000000 14.300 1.000 0801379000 8A Tomato, juice 1.000000 1.500 1.000 0801380000 8A Tomato, Tree 1.000000 1.000 1.000 0802148000 8BC Eggplant 1.000000 1.000 1.000

0802234000 8BC Okra 1.000000 1.000 1.000 0802270000 8B Pepper, bell 1.000000 1.000 1.000 0802270001 8B Pepper, bell

- babyfood 1.000000 1.000 1.0 00 0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 1.000000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 1.000000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 0901075000 9A Cantaloupe 2.000000 1.000 1.000 0901187000 9A Honeydew melon 2.000000 1.000 1.000

0901399000 9A Watermelon 2.000000 1.000 1.000 0901400000 9A Watermelon, juice 2.000000 1.000 1.000 0902021000 9B Balsam pear 0.500000 1.000 1.000 0902088000 9B Chayote, fruit 0.500000 1.000 1.000 0902102000 9B Chinese waxgourd 0.500000 1.000 1.000

0902135000 9B Cucumber 0.500000 1.000 1.000 0902308000 9B Pumpkin 0.500000 1.000 1.000 0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 0902356000 9B Squash, summer 0.500000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.500000 1.000 1.000 0902357000 9B Squash, winter 0.500000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.500000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.200000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.200000 1.000 1.000 1100008001 11 Apple, peeled fruit

- babyfood 0.200000 1.000 1.000 1100009000 11 Apple, dried 0.200000 8.000 1.00 0 D42576

Full comment: D425763 1100009001 11 Apple, dried

- babyfood 0.200000 8.000 1.000 1100010000 11 Apple, juice 0.200000 1.300 1.000 1100010001 11 Apple, juice

- babyfood 0.20000 0 1.300 1.000 1100011000 11 Apple, sauce 0.200000 1.000 1.000 1100011001 11 Apple, sauce

- babyfood 0.200000 1.000 1.000 1100129000 11 Crabapple 0.200000 1.000 1.000

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 13 of 23 1100173500 11 Goji berry 1.000000 1.000 1.000 1100210000 11 Loquat 0.200000 1.000 1.000

1100266000 11 Pear 0.200000 1.000 1.000 D42576

Full co mment: D425763

1100266001 11 Pear

- babyfood 0.200000 1.000 1.000 1100267000 11 Pear, dried 0.200000 6.250 1.000 1100268000 11 Pear, juice 0.200000 1.000 1.000

1100268001 11 Pear, juice

- babyfood 0.200000 1.000 1.000 1100310000 11 Quince 0.200000 1.000 1.000 1201090000 12A Cherry 0.200000 1.000 1.000 D42576

Full comment: D42 5763 1201090001 12A Cherry

- babyfood 0.200000 1.000 1.000 1201091000 12A Cherry, juice 0.200000 1.500 1.000 1201091001 12A Cherry, juice

- babyfood 0.200000 1.500 1.000 1202012000 12B Apri cot 0.200000 1.000 1.000 1202012001 12B Apricot

- babyfood 0.200000 1.000 1.000 1202013000 12B Apricot, dried 0.200000 6.000 1.000 1202014000 12B Apricot, juice 0.200000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 0.200000 1.000 1.000

1202230000 12B Nectarine 0.200000 1.000 1.000

1202260000 12B Peach 0.200000 1.000 1 .000

1202260001 12B Peach

- babyfood 0.200000 1.000 1.000 1202261000 12B Peach, dried 0.200000 7.000 1.000 1202261001 12B Peach, dried

- babyfood 0.200000 7.000 1.000

1202262000 12B Pe ach, juice 0.200000 1.000 1.000 1202262001 12B Peach, juice

- babyfood 0.200000 1.000 1.000

1203285000 12C Plum 0.200000 1.000 1.000

1203285001 12C Plum

- babyfood 0.200000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.200000 1.000 1.000 1203286001 12C Plum, prune, fresh

- babyfood 0.200000 1.000 1.000 1203287000 12C Plum, prune, dried 0.200000 5.000 1.000 1203287001 12C Plum, prune, dried

- babyfood 0.200000 5.000 1.000 1203288000 12C Plum, prune, juice 0.200000 1.400 1.000 1203288001 12C Plum, pru ne, juice

- babyfood 0.200000 1.400 1.000 1301055000 13A Blackberry 0.300000 1.000 1.000 1301056000 13A Blackberry, juice 0.300000 1.000 1.000 1301056001 13A Blackberry, juice

- babyfood 0.300000 1.000 1.000 1301058000 13A Boysenberry 0.300000 1.000 1.000 1301208000 13A Loganberry 0.300000 1.000 1.000 1301320000 13A Raspberry 0.300000 1.000 1.000 1301320001 13A Raspberry

- babyfood 0.300000 1.000 1.000 1301321000 13A Raspberry, juice 0.300000 1.000 1.000 1301321001 13A Raspberry, juice

- babyfood 0.300000 1.000 1.000

1302057000 13B Blueber ry 0.200000 1.000 1.000 1302057001 13B Blueberry

- babyfood 0.200000 1.000 1.000

1302136000 13B Currant 0.200000 1.000 1.000 1302137000 13B Currant, dried 0.200000 1.000 1.000 1302149000 13B Elderberry 0.200000 1.000 1.000 1302174000 13B Gooseberry 0.200000 1.000 1.000 1302191000 13B Huckleberry 0.200000 1.000 1.00 0 1307130000 13G Cranberry 0.500000 1.000 1.000 1307130001 13G Cranberry

- babyfood 0.500000 1.000 1.000 1307131000 13G Cranberry, dried 0.500000 1.000 1.000

1307132000 13G Cranb erry, juice 0.500000 1.100 1.000 1307132001 13G Cranberry, juice

- babyfood 0.500000 1.100 1.000 1307359000 13G Strawberry 3.000000 1.000 1.000 D42576

Full comment: D425763 1307359001 13G Strawberry

- babyfood 3.000000 1.000 1.000 1307360000 13G Strawberry, juice 3.000000 1.000 1.000 1307360001 13G Strawberry, juice

- babyfood 3.000000 1.000 1.000 1500120000 15 Corn, fie ld, flour 0.200000 1.000 1.000 6F7117 1500120001 15 Corn, field, flour

- babyfood 0.200000 1.000 1.000 6F7117 1500121000 15 Corn, field, meal 0.200000 1.000 1.000 6F7117 1500121001 15 Corn, field, mea l

- babyfood 0.200000 1.000 1.000 6F7117 1500122000 15 Corn, field, bran 0.200000 1.000 1.000 6F7117 1500123000 15 Corn, field, starch 0.200000 1.000 1.000 6F7117

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 14 of 23 1500123001 15 Corn, field, starch

- bab yfood 0.200000 1.000 1.000 6F7117 1500124000 15 Corn, field, syrup 0.200000 1.500 1.000 6F7117 1500124001 15 Corn, field, syrup

- babyfood 0.200000 1.500 1.000 6F7117 1500125000 15 Corn, field, oil 0.200000 1.000 1.000 6F7117 1500125001 15 Corn, field, oil

- babyfood 0.200000 1.000 1.000 6F7117 1901028000 19A Basil, fresh leaves 12.000000 1.000 1.000 4E6836 1901028001 19A Basil, fresh leaves

- babyfood 12. 000000 1.000 1.000 4E6836 1901029000 19A Basil, dried leaves 12.000000 1.000 1.000 4E6836 1901029001 19A Basil, dried leaves

- babyfood 12.000000 1.000 1.000 4E6836 1901102500 19A Chive, dried leaves 12.000000 1.000 1.000 1901118000 19A Cilantro, leaves 12.000000 1.000 1.000 4E6936 1901118001 19A Cilantro, leaves

- babyfood 12.000000 1.000 1.000 4E6936

1901144000 19A Dillweed 12.000000 1.000 1.00 0 4E6836 1901184000 19A Herbs, other 12.000000 1.000 1.000 4E6836 1901184001 19A Herbs, other

- babyfood 12.000000 1.000 1.000 4E6836 1901202000 19A Lemongrass 12.000000 1.000 1.000 4E68 36 1901220000 19A Marjoram 12.000000 1.000 1.000 4E6836 1901220001 19A Marjoram

- babyfood 12.000000 1.000 1.000 4E6836 1901249000 19A Parsley, dried leaves 12.000000 1.000 1.000 4E6836

1901 249001 19A Parsley, dried leaves

- babyfood 12.000000 1.000 1.000 4E6836 1901334000 19A Savory 12.000000 1.000 1.000 4E6836 2001163000 20A Flax seed, oil 0.600000 1.000 1.000

2001319000 20A Rapeseed, oil 0.500000 1.000 1.000 D42576

Full comment: D425763 2001319001 20A Rapeseed, oil

- babyfood 0.500000 1.000 1.000 2001336000 20A Sesame, seed 0.500000 1.000 1.000

2 001336001 20A Sesame, seed

- babyfood 0.500000 1.000 1.000 2001337000 20A Sesame, oil 0.500000 1.400 1.000 2001337001 20A Sesame, oil

- babyfood 0.500000 1.400 1.000 2002330000 20B Safflower, oil 5.000000 1.000 1.000 D42576

Full comment: D425763 2002330001 20B Safflower, oil

- babyfood 5.000000 1.000 1.000 2002364000 20B Sunflower, seed 5.000000 1.000 1.000

2002365000 20B Sunflower, oil 5.000000 1.000 1.000 2002365001 20B Sunflower, oil

- babyfood 5.000000 1.000 1.000 2003114001 20C Coconut, oil

- babyfood 1.000000 1.000 1.000 D42576

Full comment: D425 763 2003128000 20C Cottonseed, oil 1.000000 1.000 1.000 2003128001 20C Cottonseed, oil

- babyfood 1.000000 1.000 1.000 3100044000 31 Beef, meat 0.200000 1.000 1.000 3100044001 31 Beef, meat

- babyfood 0.200000 1.000 1.000 3100045000 31 Beef, meat, dried 0.200000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 3100046001 31 Beef, meat byproducts

- babyfood 0.200000 1.000 1.000 3100047000 31 Beef, fat 0.200000 1.000 1.000 3100047001 31 Beef, fat

- babyfood 0.200000 1.000 1.000 3100048000 31 Beef, kidney 0.200000 1.000 1. 000 3100049000 31 Beef, liver 0.200000 1.000 1.000 3100049001 31 Beef, liver

- babyfood 0.200000 1.000 1.000 3200169000 32 Goat, meat 0.200000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000 3200171000 32 Goat, fat 0.200000 1.000 1.000 3200172000 32 Goat, kidney 0.200000 1.000 1.000 3200173000 32 Goat, liv er 0.200000 1.000 1.000 3300189000 33 Horse, meat 0.200000 1.000 1.000 3400290000 34 Pork, meat 0.200000 1.000 1.000 3400290001 34 Pork, meat

- babyfood 0.200000 1.000 1.000 3400291000 34 Pork, skin 0.200000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.200000 1.000 1.000 3400292001 34 Pork, meat byproducts

- babyfood 0.200000 1.000 1.000 3400293000 34 Pork, fat 0.200000 1.000 1.000 3400293001 34 Pork, fat

- babyfood 0.200000 1.000 1.000 3400294000 34 Pork, kidney 0.200000 1.000 1.000 3400295000 34 Pork, l iver 0.200000 1.000 1.000 3500339000 35 Sheep, meat 0.200000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.200000 1.000 1.000

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 15 of 23 3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 3500341000 35 Sheep, fat 0.200000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.200000 1.000 1.000 3500342000 35 Sheep, kidney 0.200000 1.000 1.00 0 3500343000 35 Sheep, liver 0.200000 1.000 1.000 3600222000 36 Milk, fat 0.050000 1.000 1.000 3600222001 36 Milk, fat

- baby food/infant formu 0.050000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.050000 1.000 1.000 3600223001 36 Milk, nonfat solids

- baby food/in 0.050000 1.000 1.000 3600224000 36 Milk, water 0.050000 1.000 1.000 3600224001 36 Milk, water

- babyfood/infant fo rm 0.050000 1.000 1.000 3600225001 36 Milk, sugar (lactose)

- baby food/ 0.050000 1.000 1.000 4000093000 40 Chicken, meat 0.200000 1.000 1.000 4000093001 40 Chicken, meat

- babyfood 0.200000 1.000 1.000 4000094000 40 Chicken, liver 0.200000 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.200000 1.000 1.000 4000095001 40 Chicken, meat byproducts

- babyfoo 0.200000 1.000 1.000 4000096000 40 Chicken, fat 0.200000 1.000 1.000 4000096001 40 Chicken, fat

- babyfood 0.200000 1.000 1.000 4000097000 40 Chicken, skin 0.200000 1.000 1.000 4000097001 40 Chicken, skin

- babyfood 0.200000 1.000 1.000 5000382000 50 Turkey, meat 0.200000 1.000 1.000 5000382001 50 Turkey, meat

- babyfood 0.200000 1.000 1.000 5000383000 50 Turkey, liver 0.200000 1.000 1.000 5000383001 50 Turkey, liver

- babyfood 0.200000 1.000 1.000 5000384000 50 Turkey, meat byproducts 0.200000 1.000 1.000 5000384001 50 Turkey, meat byproducts

- babyfood 0.200000 1.000 1.000 5000385000 50 Turkey, fat 0.200000 1.000 1.000 5000385001 50 Turkey, fat

- babyfood 0.200000 1.000 1.000 5000386000 50 Turkey, skin 0.200000 1.000 1.000 5000386001 50 Turkey, skin

- babyfood 0.200000 1.000 1.000 6000301000 60 Poultry, other, meat 0.200000 1.000 1.000 6000302000 60 Poultry, other, liver 0.200000 1.000 1.00 0 6000303000 60 Poultry, other, meat byproducts 0.200000 1.000 1.000 6000304000 60 Poultry, other, fat 0.200000 1.000 1.000 6000305000 60 Poultry, other, skin 0.200000 1.000 1.000 7000145000 70 Egg, whole 0.200000 1.000 1.000 7000145001 70 Egg, whole

- babyfood 0.200000 1.000 1.000 7000146000 70 Egg, white 0.200000 1.000 1.000 7000146001 70 Egg, white (solids)

- babyfood 0.200000 1.000 1.000 7000147000 70 Egg, yolk 0.200000 1.000 1.000 7000147001 70 Egg, yolk

- babyfood 0.200000 1.000 1.000 8601000000 86A Water, direct, all sources 1.430000 1.000 1.000 8602000000 86B Water, indirect, all sources 1.430000 1.000 1.000 9500016000 O Artichoke, globe 1.200000 1.000 1.000 9500019000 O Asparagus 1.700000 1.000 1.000 5E6977 9500188000 O Hop 0.500000 1.000 1.000 5E6977

9500263000 O Peanut 3.000000 1.000 1.000 9500264000 O Peanut, butter 3.000000 1.890 1.000 9500265000 O Peanut, oil 3.000000 1.000 1.000 9500275000 O Peppermint 5.000000 1.000 1.000 9500276000 O Peppermint, oil 5.000000 1 .000 1.000 9500352000 O Spearmint 5.000000 1.000 1.000 9500353000 O Spearmint, oil 5.000000 1.000 1.000

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 16 of 23 

## Attachment 2: Acute Food and Water Results File

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for CLETHODIM NHANES 2003

- 2008 2

- Day Residue file: AcuteClethodim2016.R08 Adjustment factor #2 NOT used. Analysis Date: 01

- 19

- 2016/11:39:19 Residue file dated: 01

- 19

- 2016/11:36:41 NOEL (Acute) = 100.000000 mg/kg body

- wt/day RAC/FF intake summed over 24 hours
Run Comment: "New Acute Reference Dose; New SLUA not used; New uses

- apple, pea r, cherry, plum and crop group expansion"

===============================================================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Population:

0.102035 10.20 980 0.167895 16.79 595 0.319699 31.97 312

All Infants:

0.286813 28.68 348 0.398209 39.82 251 0.527687 52.77 189

Female 13

- 50:

0.094461 9.45 1058 0.137324 13.73 728 0.191331 19.13 522

Children 1

- 2:

0.177502 17.75 563 0.355548 35.55 281 0.906317 90.63 110

Children 3

- 5:

0.157066 15.71 636 0.225863 22.59 442 0.515648 51.56 193

Children 6

- 12:

0.105444 10.54 948 0.176090 17.61 567 0.326669 32.67 306

Youth 13

- 19:

0.080662 8.07 1239 0.130928 13 .09 763 0.181832 18.18 549

Adults 20

- 49:

0.094225 9.42 1061 0.137011 13.70 729 0.185488 18.55 539

Adults 50

- 99:

0.084808 8.48 1179 0.127349 12.73 785 0.195200 19.52 512

Female 13

- 49:

0.094612 9.46 1056 0.137415 13.74 727 0.186638 18.66 535

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 17 of 23 

## Attachment 3 : Chronic Food and Water Residue Input File

Filename: C: \ Users \ mnegussi \ Documents \ DEEM Version 3.16 \ Clethodim \ New

folder \ ChronicClethodim2016.R08

Chemical: Clethodim RfD(Chronic): .3 mg/kg bw/day NOEL(Chronic): 30 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 01

- 19

- 2016/11:42:54 Program ver. 3.16, 03

- 08

- d

Comm ent: New Chronic Reference Dose; New SLUA not used; New uses apple, pear, cherry, plum and crop group expansion;

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101050000 1AB Beet, garden, roots 1.000000 1.000 1. 000 0101050001 1AB Beet, garden, roots

- babyfood 1.000000 1.000 1.000 0101052000 1A Beet, sugar 0.200000 1.000 1.000 0101052001 1A Beet, sugar

- babyfood 0.200000 1.000 1.000

0101053000 1A Bee t, sugar, molasses 1.000000 1.000 1.000 0101053001 1A Beet, sugar, molasses

- babyfood 1.000000 1.000 1.000

0101067000 1AB Burdock 1.000000 1.000 1.000

0101078000 1AB Carrot 1.000000 1.000 1.000

0101078001 1AB Carrot

- babyfood 1.000000 1.000 1.000 0101079000 1AB Carrot, juice 1.000000 1.000 1.000

0101084000 1AB Celeriac 1.000000 1.000 1.000 0101100000 1AB Chicory, roots 1.000000 1.000 1.000 0101168000 1AB Ginseng, dried 1.000000 1.000 1.000

0101190000 1AB Horseradish 1.000000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 1.000000 1.000 1.000 0101251000 1AB Parsnip 1.000000 1.000 1.000 0101251001 1AB Parsnip

- babyfood 1.000000 1.000 1.000 0101314000 1AB Radish, r oots 1.000000 1.000 1.000 0101316000 1AB Radish, Oriental, roots 1.000000 1.000 1.000 0101327000 1AB Rutabaga 1.000000 1.000 1.000 0101331000 1AB Salsify, roots 1.000000 1.000 1.000 0101388000 1AB Turnip, roots 1.000000 1.000 1.000 0103015000 1CD Arrowroot, flour 1.000000 1.000 1.000 0103015001 1CD Arrowroot, flour

- babyfood 1.000000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 1.000000 1.000 1.000

0103082000 1CD Cassava 1.000000 1.000 1.000

0103082001 1CD Cassava

- babyfood 1.000000 1.000 1.000

0103139000 1CD Dasheen , corm 1.000000 1.000 1.000 0103166000 1CD Ginger 1.000000 1.000 1.000 0103166001 1CD Ginger

- babyfood 1.000000 1.000 1.000 0103167000 1CD Ginger, dried 1.000000 1.000 1.000 0103296000 1C Potato, chips 1.000000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 2.000000 1.000 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 2.000000 1.000 1.00 0 0103298000 1C Potato, flour 1.000000 6.500 1.000 0103298001 1C Potato, flour

- babyfood 1.000000 6.500 1.000 0103299000 1C Potato, tuber, w/peel 1.000000 1.000 1.000

0103299001 1C Potat o, tuber, w/peel

- babyfood 1.000000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 1.000000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 1.000000 1.000 1.000 0103366000 1CD Sweet potato 1.000000 1.000 1.000 0103366001 1CD Sweet potato

- babyfood 1.000000 1.000 1.000 0103371000 1CD Tanier, corm 1.000000 1.000 1.000

0103387000 1CD Turmeric 1.000000 1.000 1.000 0103406000 1CD Yam, true 1.000000 1.000 1.000

0103407000 1CD Yam bean 1.000000 1.000 1.000 0200315000 2 Radish, t ops 0.700000 1.000 1.000 0200317000 2 Radish, Oriental, tops 0.700000 1.000 1.000 0301165000 3A Garlic, bulb 0. 5 00000 1.000 1.000 D42576

Full comment: D425763

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 18 of 23 0301165001 3A Garlic, bulb

- babyfood 0. 5 00000 1.000 1.000 0301237000 3A Onion, bulb 0. 5 00000 1.000 1.000 0301237001 3A Onion, bulb

- babyfood 0. 5 00000 1.000 1.000 0301238000 3A Onion, bulb, dried 0. 5 00000 9.000 1.000 0301238001 3A Onion, bulb, dried

- babyfood 0. 5 00000 9.000 1.000 0301338000 3A Shallot, bulb 0. 5 00000 1.000 1.000 0302103000 3B Chive, fresh leaves 12.000000 1.000 1.000 4E6836 0302239000 3B Onion, green 2.000000 1.000 1.000 0401005000 4A Amaranth, leafy 2.000000 1.000 1.000 5E6978 0401018000 4A Arugula 2.000000 1.000 1.00 0 5E6978 0401104000 4A Chrysanthemum, garland 2.000000 1.000 1.000 5E6978 0401133000 4A Cress, garden 2.000000 1.000 1.000 5E6978 0401134000 4A Cress, upland 2.000000 1.000 1.000 5E69 78 0401138000 4A Dandelion, leaves 2.000000 1.000 1.000 5E6978

0401150000 4A Endive 2.000000 1.000 1.000 5E6978 0401204000 4A Lettuce, head 2.000000 1.000 1.000 5E6978

0401 205000 4A Lettuce, leaf 2.000000 1.000 1.000 5E6978 0401248000 4A Parsley, leaves 2.000000 1.000 1.000 5E6978

0401313000 4A Radicchio 2.000000 1.000 1.000 5E6978

0401355000 4A Spinach 2.000000 1.000 1.000 5E6978 0401355001 4A Spinach

- babyfood 2.000000 1.000 1.000 5E6978

0402076000 4B Cardoon 0.600000 1.000 1.000 0402085000 4B Celery 0.600000 1.000 1.000 0402085001 4B Celery

- babyfood 0.600000 1.000 1.000 0402086000 4B Celery, juice 0.600000 1.000 1.000

0402087000 4B Celtuce 0.600000 1.000 1.000 0402152000 4B Fennel, Florence 0.600000 1.000 1.000

0402322000 4B Rhubarb 0.600000 1.000 1.000

0402367000 4B Swiss chard 0.600000 1.000 1.000

0501061000 5A Broccoli 3.000000 1.000 1.000

0501061001 5A Broccoli

- babyfood 3.000000 1.000 1.000 0501062000 5A Broccoli, Chinese 3.000000 1.000 1.000 0501064000 5A Brussels sprouts 3.000000 1.000 1.000 0501069000 5A Cabbage 3.000000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 3.000000 1.000 1.000 0501072000 5A Cabbage , Chinese, mustard 3.000000 1.000 1.000

0501083000 5A Cauliflower 3.000000 1.000 1.000

0501196000 5A Kohlrabi 3.000000 1.000 1.000

0502063000 5B Broccoli raab 3.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 3.000000 1.000 1.000

0502117000 5B Collards 3.000000 1.000 1.000

0502194000 5B Kale 3.000000 1.000 1.00 0 0502229000 5B Mustard greens 3.000000 1.000 1.000 0502318000 5B Rape greens 3.000000 1.000 1.000 0502389000 5B Turnip, greens 3.000000 1.000 1.000 0600347000 6 Soybe an, seed 10.000000 1.000 1.000 0600349000 6 Soybean, soy milk 10.000000 1.000 1.000 0600349001 6 Soybean, soy milk

- babyfood or in 10.000000 1.000 1.000 0600350000 6 Soybean, oil 10.000000 1.000 1.000 0600350001 6 Soybean, oil

- babyfood 10.000000 1.000 1.000 0601043000 6A Bean, snap, succulent 3.500000 1.000 1.000 4F6895 0601043001 6A Bean, snap, succulent

- babyfood 3.500000 1.000 1.000 4F6895 0601257000 6A Pea, edible podded, succulent 3.500000 1.000 1.000 4F6895 0602031000 6B Bean, broad, succulent 3.500000 1.000 1.000 4F6895 0602033000 6B Bean, cowpea, succulent 3.500000 1.000 1.000 4F6895 0602037000 6B Bean, lima, succulent 3.500000 1.000 1.000 4F6895 0602255000 6B Pea, succulent 3.500000 1.000 1.000 4F6895 0602255001 6B Pea, succulent

- babyfood 3.500000 1.000 1.000 4F6895 0602259000 6B Pea, pigeon, succulent 3.500000 1.000 1.000 4F6895 0603030000 6C Bean, black, seed 3.500000 1.000 1.000 4F6895 0603032000 6C Bean, broad, seed 3.500000 1.000 1.000 4F6895 0603034000 6C Bean, cowpea, seed 3.500000 1.000 1.000 4F6895 0603035000 6C Bean, great northern, seed 3.500000 1.000 1.000 4F6895 0603036000 6C Bean, kidney, seed 3.500000 1.000 1.000 4F6895

0603038 000 6C Bean, lima, seed 3.500000 1.000 1.000 4F6895 0603039000 6C Bean, mung, seed 3.500000 1.000 1.000 4F6895

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 19 of 23 0603040000 6C Bean, navy, seed 3.500000 1.000 1.000 4F6895

0603041000 6C Bean, pink, seed 3.500000 1.000 1.000 4F6895 0603042000 6C Bean, pinto, seed 3.500000 1.000 1.000 4F6895 0603098000 6C Chickpea, seed 3.500000 1.000 1.000 4F6895

0603098001 6C Chick pea, seed

- babyfood 3.500000 1.000 1.000 4F6895 0603099000 6C Chickpea, flour 3.500000 1.000 1.000 4F6895 0603182000 6C Guar, seed 3.500000 1.000 1.000 4F6895 0603182001 6C Guar, seed

- b abyfood 3.500000 1.000 1.000 4F6895 0603203000 6C Lentil, seed 3.500000 1.000 1.000 4F6895 0603256000 6C Pea, dry 3.500000 1.000 1.000 4F6895 0603256001 6C Pea, dry

- babyfood 3.500000 1.000 1.000 4F6895 0603258000 6C Pea, pigeon, seed 3.500000 1.000 1.000 4F6895 0603348000 6C Soybean, flour 10.000000 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 10.000000 1.000 1.000

0801374000 8A Tomatillo 1.000000 1.000 1.000

0801375000 8A Tomato 1.000000 1.000 1.000

0801375001 8A Tomato

- ba byfood 1.000000 1.000 1.000 0801376000 8A Tomato, paste 1.000000 5.400 1.000 previo

Full comment: previous tolerance expired 4/30/03 0801376001 8A Tomato, paste

- babyfood 1.000000 5.400 1.000 previo

Full comment: previous tolerance expired 4/30/03 0801377000 8A Tomato, puree 1.000000 3.300 1.000 previo

Full comment: previous tolerance expired 4/30/03 0801377001 8A Tomato, pure e

- babyfood 1.000000 3.300 1.000 previo

Full comment: previous tolerance expired 4/30/03 0801378000 8A Tomato, dried 1.000000 14.300 1.000 0801378001 8A Tomato, dried

- babyfood 1.000000 14 .300 1.000 0801379000 8A Tomato, juice 1.000000 1.500 1.000 0801380000 8A Tomato, Tree 1.000000 1.000 1.000 0802148000 8BC Eggplant 1.000000 1.000 1.000

0802234000 8BC Okra 1.000000 1.000 1.000 0802270000 8B Pepper, bell 1.000000 1.000 1.000 0802270001 8B Pepper, bell

- babyfood 1.000000 1.000 1.000 0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 1.000000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 1.000000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 0901075000 9A Cantaloupe 2.000000 1.000 1.000 0901187000 9A Honeydew melon 2.000000 1.000 1.000

090139900 0 9A Watermelon 2.000000 1.000 1.000 0901400000 9A Watermelon, juice 2.000000 1.000 1.000 0902021000 9B Balsam pear 0.500000 1.000 1.000 0902088000 9B Chayote, fruit 0.500000 1.000 1.000 0902102000 9B Chinese waxgourd 0.500000 1.000 1.000

0902135000 9B Cucumber 0.500000 1.000 1.000 0902308000 9B Pumpkin 0.500000 1.000 1.000 0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 0902356000 9B Squash, summer 0.500000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.500000 1.000 1.000 0902357000 9B Squash, winter 0.500000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.500000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.200000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.200000 1.000 1.000 1100008001 11 Apple, peeled fruit

- babyfood 0.200000 1.000 1.000 1100009000 11 Apple, dried 0.200000 8.000 1.000 D42576

Full comment: D425763 1100009001 11 Apple, dried

- babyfood 0.200000 8.000 1.000 1100010000 11 Apple, juice 0.200000 1.300 1.000 1100010001 11 Apple, juice

- babyfood 0.200000 1.300 1.000

11000110 00 11 Apple, sauce 0.200000 1.000 1.000 1100011001 11 Apple, sauce

- babyfood 0.200000 1.000 1.000 1100129000 11 Crabapple 0.200000 1.000 1.000 1100173500 11 Goji berry 1.000000 1.000 1.000 1100210000 11 Loquat 0.200000 1.000 1.000

1100266000 11 Pear 0.200000 1.000 1.000 D42576

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 20 of 23 Full comment: D425763

1100266001 11 Pe ar

- babyfood 0.200000 1.000 1.000 1100267000 11 Pear, dried 0.200000 6.250 1.000 1100268000 11 Pear, juice 0.200000 1.000 1.000 1100268001 11 Pear, juice

- babyfood 0.200000 1.000 1.000 1100310000 11 Quince 0.200000 1.000 1.000 1201090000 12A Cherry 0.200000 1.000 1.000 D42576

Full co mment: D425763 1201090001 12A Cherry

- babyfood 0.200000 1.000 1.000 1201091000 12A Cherry, juice 0.200000 1.500 1.000 1201091001 12A Cherry, juice

- babyfood 0.200000 1.500 1.000

1202012000 12B Apricot 0.200000 1.000 1.000 1202012001 12B Apricot

- babyfood 0.200000 1.000 1.000 1202013000 12B Apricot, dried 0.200000 6.000 1.000 1202014000 12B Apricot, juice 0.200000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 0.200000 1.000 1.000

1202230000 12B Nectarine 0.200000 1.000 1.000

1202260000 12B Peach 0.200000 1.000 1.000

1202260001 12B Peach

- babyfood 0.200000 1.000 1.000 1202261000 12B Peach, dried 0.200000 7.000 1.000 1202261001 12B Peach, dried

- babyfood 0.200000 7.000 1.000

12022620 00 12B Peach, juice 0.200000 1.000 1.000 1202262001 12B Peach, juice

- babyfood 0.200000 1.000 1.000

1203285000 12C Plum 0.200000 1.000 1.000 D42576

Full comment: D 425763

1203285001 12C Plum

- babyfood 0.200000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.200000 1.000 1.000 1203286001 12C Plum, prune, fresh

- babyfood 0.200000 1.000 1.000

1203287000 12C Pl um, prune, dried 0.200000 5.000 1.000 1203287001 12C Plum, prune, dried

- babyfood 0.200000 5.000 1.000 1203288000 12C Plum, prune, juice 0.200000 1.400 1.000 1203288001 12C Plum, prune, juice

- babyfood 0.200000 1.400 1.000 1301055000 13A Blackberry 0.300000 1.000 1.000 1301056000 13A Blackberry, juice 0.300000 1.000 1.000 1301056001 13A Blackberry, juice

- babyfood 0.300000 1.000 1.000 1301058000 13A Boysenberry 0.300000 1.000 1.000 1301208000 13A Loganberry 0.300000 1.000 1.000 1301320000 13A Raspberry 0.300000 1.000 1.000 1301320001 13A Raspberry

- babyfood 0.300000 1.000 1.000 1301321000 13A Raspberry, juice 0.300000 1.000 1.000 1301321001 13A Raspberry, juice

- babyfood 0.300000 1.000 1.000 1302057000 13B Blueberry 0.200000 1.000 1.000 1302057001 13B Blueberry

- babyfood 0.200000 1.000 1.000

1302136000 13B Currant 0.200000 1.000 1.000 1302137000 13B Currant, dried 0.200000 1.000 1.000 1302149000 13B Elderberry 0.200000 1.000 1.000 1302174000 13B Gooseberry 0.200000 1.000 1.000

1302191000 13B Huckleb erry 0.200000 1.000 1.000 1307130000 13G Cranberry 0.500000 1.000 1.000 1307130001 13G Cranberry

- babyfood 0.500000 1.000 1.000 1307131000 13G Cranberry, dried 0.500000 1.000 1.000 1307132000 13G Cranberry, juice 0.500000 1.100 1.000 1307132001 13G Cranberry, juice

- babyfood 0.500000 1.100 1.000 1307359000 13G Strawberry 3.000000 1.000 1.00 0 1307359001 13G Strawberry

- babyfood 3.000000 1.000 1.000 1307360000 13G Strawberry, juice 3.000000 1.000 1.000 1307360001 13G Strawberry, juice

- babyfood 3.000000 1.000 1.000 1500120000 15 Corn, field, flour 0.200000 1.000 1.000 6F7117 1500120001 15 Corn, field, flour

- babyfood 0.200000 1.000 1.000 6F7117 1500121000 15 Corn, field, meal 0.200000 1.000 1.000 6F7117 1500121001 15 Corn, field, meal

- babyfood 0.200000 1.000 1.000 6F7117 1500122000 15 Corn, field, bran 0.200000 1.000 1.000 6F7117 1500123000 15 Corn, field, starch 0.200000 1.000 1.000 6F7117 1500123001 15 Corn, field, starch

- babyfood 0.200000 1.000 1.000 6F7117 1500124000 15 Corn, field, syrup 0.200000 1.500 1.000 6F7117 1500124001 15 Corn, field, syrup

- babyfood 0.200000 1.500 1.000 6F7117

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 21 of 23 1500125000 15 Corn, field, oil 0.200000 1.000 1.000 6F7117 1500125001 15 Corn, field, oil

- babyfood 0.200000 1.000 1.000 6F7117 1901028000 19A Basil, fresh leaves 12.000000 1.000 1.000 4E6836 1901028001 19A Basil, fresh leaves

- babyfoo d 12.000000 1.000 1.000 4E6836 1901029000 19A Basil, dried leaves 12.000000 1.000 1.000 4E6836 1901029001 19A Basil, dried leaves

- babyfood 12.000000 1.000 1.000 4E6836 1901102500 19A Chive, dried leaves 12.000000 1.000 1.000 1901118000 19A Cilantro, leaves 12.000000 1.000 1.000 4E6936 1901118001 19A Cilantro, leaves

- babyfood 12.000000 1.000 1.000 4E6936

1901144000 19A Dillweed 12.000000 1 .000 1.000 4E6836 1901184000 19A Herbs, other 12.000000 1.000 1.000 4E6836 1901184001 19A Herbs, other

- babyfood 12.000000 1.000 1.000 4E6836 1901202000 19A Lemongrass 12.000000 1.000 1 .000 4E6836 1901220000 19A Marjoram 12.000000 1.000 1.000 4E6836 1901220001 19A Marjoram

- babyfood 12.000000 1.000 1.000 4E6836 1901249000 19A Parsley, dried leaves 12.000000 1.000 1.000 4 E6836 1901249001 19A Parsley, dried leaves

- babyfood 12.000000 1.000 1.000 4E6836 1901334000 19A Savory 12.000000 1.000 1.000 4E6836 2001163000 20A Flax seed, oil 0.600000 1.000 1.000

2001319 000 20A Rapeseed, oil 0.500000 1.000 1.000 2001319001 20A Rapeseed, oil

- babyfood 0.500000 1.000 1.000 D42576

Full comment: D425763 2001336000 20A Sesame, seed 0.500000 1.000 1.000 2001336001 20A Sesame, seed

- babyfood 0.500000 1.000 1.000 2001337000 20A Sesame, oil 0.500000 1.400 1.000 2001337001 20A Sesame, oil

- babyfood 0.500000 1.400 1.000

2002330000 20B Safflower, oil 5.000000 1.000 1.000 D42576

Full comment: D425763 2002330001 20B Safflower, oil

- babyfood 5.000000 1.000 1.000 2002364000 20B Sunflower, seed 5.000000 1.000 1.000

2 002365000 20B Sunflower, oil 5.000000 1.000 1.000 2002365001 20B Sunflower, oil

- babyfood 5.000000 1.000 1.000 2003114001 20C Coconut, oil

- babyfood 1.000000 1.000 1.000 D42576

Full com ment: D425763 2003128000 20C Cottonseed, oil 1.000000 1.000 1.000 2003128001 20C Cottonseed, oil

- babyfood 1.000000 1.000 1.000 3100044000 31 Beef, meat 0.200000 1.000 1.000

3100044001 31 Beef, meat

- babyfood 0.200000 1.000 1.000 3100045000 31 Beef, meat, dried 0.200000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 3100046001 31 Beef, meat byproduct s

- babyfood 0.200000 1.000 1.000 3100047000 31 Beef, fat 0.200000 1.000 1.000 3100047001 31 Beef, fat

- babyfood 0.200000 1.000 1.000 3100048000 31 Beef, kidney 0.200000 1.000 1.000 3100049000 31 Beef, liver 0.200000 1.000 1.000 3100049001 31 Beef, liver

- babyfood 0.200000 1.000 1.000 3200169000 32 Goat, meat 0.200000 1.000 1.000

320017000 0 32 Goat, meat byproducts 0.200000 1.000 1.000 3200171000 32 Goat, fat 0.200000 1.000 1.000 3200172000 32 Goat, kidney 0.200000 1.000 1.000 3200173000 32 Goat, liver 0.200000 1.000 1.000 3300189000 33 Horse, meat 0.200000 1.000 1.000 3400290000 34 Pork, meat 0.200000 1.000 1.000 3400290001 34 Pork, meat

- babyfood 0.200000 1.000 1.000 3400291000 34 Pork, skin 0.200000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.200000 1.000 1.000 3400292001 34 Pork, meat byproducts

- babyfood 0.200000 1.000 1.000 3400293000 34 Pork, fat 0.200000 1.000 1.000 3400293001 34 Pork, fat

- babyfood 0.200000 1.000 1.000 3400294000 34 Pork, kidney 0.200000 1.000 1.000 3400295000 34 Pork, liv er 0.200000 1.000 1.000 3500339000 35 Sheep, meat 0.200000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.200000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 3500341000 35 Sheep, fat 0.200000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.200000 1.000 1.000

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 22 of 23 3500342000 35 Sheep, kidney 0.200000 1.000 1.000 3500343000 35 Sheep, liver 0.200000 1.000 1.000 3600222000 36 Milk, fat 0.050000 1.000 1.000 3600222001 36 Milk, fat

- baby food/infant formu 0.050000 1.000 1.000 3600223000 36 Milk, n onfat solids 0.050000 1.000 1.000 3600223001 36 Milk, nonfat solids

- baby food/in 0.050000 1.000 1.000 3600224000 36 Milk, water 0.050000 1.000 1.000 3600224001 36 Milk, water

- babyfood/infant form 0.050000 1.000 1.000 3600225001 36 Milk, sugar (lactose)

- baby food/ 0.050000 1.000 1.000 4000093000 40 Chicken, meat 0.200000 1.000 1.000 4000093001 40 Chicken, meat

- babyfood 0.200000 1.000 1.00 0 4000094000 40 Chicken, liver 0.200000 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.200000 1.000 1.000 4000095001 40 Chicken, meat byproducts

- babyfoo 0.200000 1.000 1.000

4000096000 40 Chick en, fat 0.200000 1.000 1.000 4000096001 40 Chicken, fat

- babyfood 0.200000 1.000 1.000 4000097000 40 Chicken, skin 0.200000 1.000 1.000 4000097001 40 Chicken, skin

- babyfood 0.200000 1.000 1.000 5000382000 50 Turkey, meat 0.200000 1.000 1.000 5000382001 50 Turkey, meat

- babyfood 0.200000 1.000 1.000 5000383000 50 Turkey, l iver 0.200000 1.000 1.000 5000383001 50 Turkey, liver

- babyfood 0.200000 1.000 1.000 5000384000 50 Turkey, meat byproducts 0.200000 1.000 1.000 5000384001 50 Turkey, meat byproducts

- babyfood 0.200000 1.000 1.000 5000385000 50 Turkey, fat 0.200000 1.000 1.000 5000385001 50 Turkey, fat

- babyfood 0.200000 1.000 1.000 5000386000 50 Turkey, skin 0.200000 1.000 1.000 5000386001 50 Turkey, skin

- babyfood 0.200000 1.000 1.000 6000301000 60 Poultry, other, meat 0.200000 1.000 1.000 6000302000 60 Poultry, other, liver 0.200000 1.000 1.000 6000303000 60 Poultry , other, meat byproducts 0.200000 1.000 1.000 6000304000 60 Poultry, other, fat 0.200000 1.000 1.000 6000305000 60 Poultry, other, skin 0.200000 1.000 1.000 7000145000 70 Egg, whole 0.200000 1.000 1.000 7000145001 70 Egg, whole

- babyfood 0.200000 1.000 1.000 7000146000 70 Egg, white 0.200000 1.000 1.000 7000146001 70 Egg, white (solids)

- babyfood 0.200000 1.000 1.00 0 7000147000 70 Egg, yolk 0.200000 1.000 1.000 7000147001 70 Egg, yolk

- babyfood 0.200000 1.000 1.000 8601000000 86A Water, direct, all sources 1.150000 1.000 1.000

8602000000 86B Water , indirect, all sources 1.150000 1.000 1.000 9500016000 O Artichoke, globe 1.200000 1.000 1.000 9500019000 O Asparagus 1.700000 1.000 1.000 5E6977 9500188000 O Hop 0.500000 1.000 1.000 5E6977

9500263000 O Peanut 3.000000 1.000 1.000 9500264000 O Peanut, butter 3.000000 1.890 1.000 Harmon

Full comment: Harmonize with Codex 9500265000 O Peanut, oil 3.000000 1.000 1.000 9500275000 O Peppermint 5.000000 1.000 1.000 9500276000 O Peppermint, oil 5.000000 1.000 1.000 9500352000 O Spearmint 5.000000 1.000 1.000 9500353000 O Spearmint, oil 5.000000 1.000 1.000

### Clethodim Dietary Exposure and Risk Assessment DP Number: 431223

PC Code: 121011

______________________________________________________________________________________

Page 23 of 23 

## Attachment 4 : Chronic Food and Water Re sult File

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for CLETHODIM NHANES 2003

- 2008 2

- day

Residue file name: C: \ Documents and Settings \ MNEGUSSI \ My Documents \ DEEM Version

3.16 \ Clethodim \ New folder \ ChronicClethodim2016.R08 Adjustment factor #2 NOT used. Analysis Date 01

- 19

- 2016/11:44:19 Residue file dated: 01

- 19

- 2016/11:42:54 Reference dose (RfD, Chronic) = .3 mg/kg bw/day COMMENT 1: New Chronic Reference Dose; New uses apple, pear, cherry, plum and crop group expansion;

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.037592 12.5% Hispanic 0.037148 12.4%

Non

- Hisp

- White 0.038086 12.7%

Non

- Hisp

- Black 0.032509 10.8%

Non

- Hisp

- Other 0.044262 14.8% Nursing Infants 0.035322 11.8%

Non

- Nursing Infants 0.114860 38.3%

Female 13+ PREG 0.034795 11.6%

Children 1

- 6 0.065046 21.7%

Children 7

- 12 0.038039 12.7%

Male 13

- 19 0.028061 9.4%

Female 13

- 19/NP 0.029350 9.8%

Male 20+ 0.033038 11.0% Female 20+/NP 0.035985 12.0%

Seniors 55+ 0.033746 11.2%

All Infants 0.0903 04 30.1%

Female 13

- 50 0.034534 11.5%

Children 1

- 2 0.074277 24.8%

Children 3

- 5 0.061470 20.5%

Children 6

- 12 0.040639 13.5%

Youth 13

- 19 0.028696 9.6%

Adults 20

- 49 0.034796 11.6%

Adults 50

- 99 0.034303 11.4%

Female 13

- 49 0.034543 11.5%

-------------------------------------------------------------------------------