Page 3 of 13



### less than that by the oral route and toxicity by the dermal route at environmental concentrations is not expected. Therefore, quantitation of risk followi ng dermal exposure was not required.

No teratogenic effects were noted in a rabbit developmental study at the high dose of 10 mg/kg/day. Children born to mothers treated with streptomycin injections have sometimes had hearing loss; no teratogenic effec ts have been attributed to streptomycin treatment. Because the dose selected for risk assessment is much lower than the injected dose at which toxicity occurs in humans, there are no residual concerns and the Food Quality Protection Act ( FQPA ) safety

fact or was reduced to 1x.

Table 1. Toxicological Doses and Endpoints for Streptomycin Human Risk Assessment

Exposure Dose and Uncertainty

Factors Special FQPA Safety

Factor Study and Toxicological Effects

Acute Dietary (any population) N/A N/A Toxicity from single

- dose exposure not identified

.
Chronic Dietary (all populations) NOAEL = 5 mg/kg/day

UF = 100

chronic RfD = 0.05 mg/kg/day FQPA SF = 1X

chronic PAD = 0.05 mg/kg/day 2

- year feeding study in rats LOAEL = 10 mg/kg/day based on reduced body weight gain

Inhalation

exposure (all durations) NOAEL = 5 mg/kg/day

UF = 100 FQPA SF = 1X 2

- year feeding study in rats LOAEL = 10 mg/kg/day based on reduced body weight gain

Dermal exposure N/A N/A Not required because of minimal dermal absorption.

Cancer Classification: " Inadequate Information to Assess Carcinogenic Potential "

UF = uncertainty factor, FQPA SF = FQPA safety factor, NOAEL = no observed adverse effect level, LOAEL = lowest observed adverse effect level, chronic RfD = chronic reference dose = NOAEL/UF, NA = Not Applicable, PAD = population adjusted dose = RfD/FQPA SF



### Residue Chemistry

To support the emergency exemption for use of streptomycin in gr apefruit, eight field trials were performed in the states of California (2), Florida (5) and Texas (1). Detailed information about the location of the field trials is not available; however, the number of field trials per region

follows the recommendation s of the OPPTS 860.1500 guideline. S treptomycin was applied as

the Firewall formulation which is a wettable powder containing 22.4% streptomycin sulfate

. The application method was not described; t wo applications were performed at a rate of 0.448 lb ai/A

with a 21

- day RTI . The petition requested a 21

- day PHI, but the field trials had a 60

- day PHI.

S amples were analyzed by the analytical method entitled, “Confirmation of Aminoglycosides by

HPLC

- MS/MS”; United States Department of Agriculture, Food Safe ty and Inspection Service, Office of Public Health Science, SOP No: CLG

- AMG1.02; Effective June 1, 2005. The registrant states that method validation and concurrent recoveries were between 70

- 120%. Duplicate samples were collected and analyzed for parent streptomycin. Streptomycin residues

found in grapefruit were 0.0090

- 0.0855 ppm (see Table 2)

. The OECD tolerance calculation procedures (March 2011 version) were used to determine the appropriate tolerance level forPage 4 of 13



### grapefruit ; see Appendix A

. Thus, a tolerance level of 0.15 ppm is appropriate for streptomycin

in/on grapefruit. This recommendation is lower than toleranc e level (0.20 ppm) proposed by the petitioner.

Table 2 . Residues of Streptomycin in Grapefruit (ppm)

Trial Sample 1 Sample 2 Average

08

- CA08 0.0230 0.0211 0.022

08

- CA09 0.0090 0.0096 0.010

08

- FL53 0.0380 0.0244 0.031

08

- FL54 0.0185 0.0236 0.021

08

- FL55 0.0281 0.0547 0.041

08

- FL56 0.0583 0.0855 0.072

08

- FL57 0.0656 0.0699 0.066

08

- TX01 0.0479 0.0394 0.044

A processing study was done by treating a plot at a 5X rate and harvesting 60 days after

treatment. Residues in the raw agricultural commodity were 0.167 ppm. The grapefruit was processed to juice, oil and dried pulp. No concentration was observed for g rapefruit juice or oil; therefore, residues in these commodities are covered by the tolerance for grapefruit. The dried pulp had residues of approximately 0.76 ppm which leads to a concentration factor (CF) of 4.5X. The highest average field trial (HAFT) is 0.072 ppm and a 4.5 X CF was reported for grapefruit pulp. A tolerance of 0.4 0 ppm ( HAFT x CF = 0. 0 72 ppm x 4.5 = 0.32 ppm) is recommended for grapefruit, dried pulp.

Table 3. Tolerance Summary for Streptomycin.

Commodity Tolerance (ppm) Comments; Correct Commodity Definition Established Proposed Recommended

Grapefruit 1 

### None 0.20 0.15

Grapefruit, dried pulp 2 

### None 1.0 0.40

1 OECD tolerance calculation procedures were used to estimate the tolerance recommended for grapefruit. The tolerance proposed by the petitioner was obtained NAFTA tolerance calculation procedures.

. 2 The tolerance recommended was obtained from the product of the HAFT and the CF. The registrant u sed the tolerance proposed for grapefruit instead of the HAFT.



### Conclusion: The data submitted supports two applications of Firewall to grapefruit at maximum single rate of 0.448 lb ai/A with a 21

- day RTI and a 60

- day PHI. Tolerances of 0.15 ppm and 0.40 ppm are recommended for grapefruit and grapefruit, dried pulp, respectively.Page 5 of 13



### Dietary Exposure

The last dietary assessment for streptomycin was conducted to support the tolerance reassessment eligibili ty decision (T. Goodlow, D310391, 01/09/2006). To support the current emergency exception, c hronic dietary risk assessments including food and drinking water were conducted using the Dietary Exposure Evaluation Model DEEM

- FCIDTM , Version 2.0 3

. A chronic p opulation adjusted dose (cPAD) of 0.05 mg/kg/day was used . No acute dietary toxicity endpoint was identified from the streptomycin toxicology data base . C ancer quantitati o n was not required

.

The chronic assessment used tolerance level residues for all registered commodities , plus grapefruit (0.15 ppm was used for grapefruit and grapefruit juice). In addition, default processing factors were used for all commodities except grapefruit juice. One hundred percent crop treated was assumed for all crops. T he e stimated drin king water concentration (EDWC ) for surface water (51.4 ppb) provided by the Environmental Fate and Effe cts Division (EFED) w as used

. The EDWC is based on aerial application to apple orchards. Dietary risk estimates for food and drinking water were below the Agency’s level of concern. The highest exposure was for children 1<2 years old (0.006486 mg/kg/day) which utilized 13 % of the chronic population adjusted dose (cPAD). Accordingly , the proposed emergency exemption will not result in dietary

risks of concern with a 60

- day PHI

.

Table 4 . Summary of Estimated Chronic Dietary (Food and Drinking Water) Exposure and Risk for Streptomycin

Population Subgroup Dietary Exposure (mg/kg/day) % cPAD

General U.S. Population 0.002303 4.6

All Infants (< 1 year old) 0.006393 13

Children 1

- 2 years old 0.006486 13

Children 3

- 5 years old 0.004926 9.9

Children 6

- 12 years old 0.002756 5.5

Youth 13

- 19 years old 0.001797 3.6

Adults 20

- 49 years old 0.001853 3.7 Adults 50+ years old 0.001879 3.8

Females 13

- 49 years old 0.001832 3.7Page 6 of 13



### Residential Exposure and Risk Assessment

Estimated r isks for homeowner users of streptomycin products were assessed in the 2006 streptomycin risk assessment because labels gi ve directions for applying in residential environments (e.g., EPA Reg No.s 74011

- 311 and 80990

- 4, the latter is the label associated w ith this action). Streptomycin would be used in residential areas to control the same diseases (e.g., blight, various rots) as it would in commercial greenhouse and agricultural settings. Applications would typically be made to trees and various types of shrubs. How exposures for these types of uses are addressed in risk assessment is described in the recently updated Standard Operating Procedures for Residential Exposure Assessment (SOPs)

. 1



### Streptomycin is not significantly absorbed through the dermal route

. Hence , only inhalation exposures are pertinent for risk assessment

. Estimated inhalation risks for residential applicators have been recalculated for this assessment to reflect the most up to date residential SOPs which describe both the applicable scenarios that should be considered and how the calculations should be completed

. The algorithms and other inputs used for the calculations are described in the SOPs. The point of departure, as described above, is a NOAEL of 5 mg/kg/day based on a 2

yea r feeding study in rats based on reduced body weight gain with a total uncertainty factor of

100. The application rate (i.e., lb ai/gallon input parameter) is based on the same values specified in the 2006 TRED for consistency because the cited label is c learly intended for residential users (EPA Reg 74011

- 311). The label associated with this action (EPA Reg 80990

- 4) also allows for uses in a residential environment at a slightly higher application rate (i.e., 0.00112 instead of 0.00085 lb ai/gallon) but it is likely that, because of the resistance management issues stipulated on this label, that this product would not be used by homeowners.

For all scenarios considered estimated risks are not of concern (i.e., Margins of Exposure or

MOEs exceed the target of 100 in all cases) : the lowest calculated MOE is 86,000. Based on the scenarios considered, the absorbed dose recommended for aggregation purposes is 0.000058 mg/kg/day. If the application rate for EPA Reg 80990

- 4 was considered it would not alt er the outcome of this assessment given the minor differences in application rate relative to the magnitude of the MOEs which were calculated.

Although a quantitative residential post

- application inhalation exposure assessment was not performed, an inhala tion exposure assessment was performed for handlers. This exposure scenario is representative of a worse case inhalation exposure and is protective of any potential

post

- application inhalation exposure.

1 http://www.epa.gov/pesticides/science/residential

- exposure

- sop.htmlPage 7 of 13 

### Table 5. Inhalation Risks For Homeowners Who Mix and Apply Streptomycin

Scenario Formulation Application Equipment/Method Inhalation

Unit Exposure (mg/lb ai) Application

Rate ( lb ai/gallon ) Amount

Handled Daily ( gallons ) Inhalation

Absorbed

Dose (mg/kg/day) I nhalation

MOE

Gardens /

Trees Wettable

powders Manually

pressurized

Handwand 1.1 0.00085 5 0.000058 86,000

Gardens /

Trees Wettable

powders Hose

- end Sprayer 0.0014 0.00085 11 0.00000016 31,000,000

Gardens /

Trees Wettable

powders Backpack 1.1 0.00085 5 0.000058 86,000

Gardens /

Trees Wettable

powders Sprinkler can 0.0014 0.00085 5 0.000000074 67,000,000



### Aggregate Exposure Assessment

In accordance with the FQPA, HED must consider and aggregate (add) pesticide exposures and risks from three major sources: food, dri nking water, and residential exposures. In an aggregate assessment, exposures from relevant sources are added together and compared to the quantitative

estimate of hazard (e.g., a NOAEL in this case ). When aggregating exposures and risks from

various sou rces, HED considers both the route and duration of exposure.

Aggregate exposure for streptomycin included oral (food and water ) and inhalation routes. The population group with both the highest dietary exposure and a residential component of the

aggrega te

, the general US population , was used to assess aggregate exposure

. The dermal route

was not included because no dermal hazard exists for this chemical, as noted previously.

Table 6 . Short

- Term Aggregate Risk Calculations

Population NOAEL

mg/kg/day LOC 1 Max

Allowable Exposure 2
mg/kg/day Average

Food and

Water Exposure mg/kg/day Residential

Exposure mg/kg/day 3 Total

Exposure mg/kg/day 4 Aggregate

MOE (food, water, and residential) 5

General US population 5 100 0.05 0.002303 0.000058 0.002361 2100

1 The Level of Concern = 100, based on a 10x interspecies UF and a 10x intraspecies UF.

2 Maximum Allowable Exposure (mg/kg/day) = NOAEL/LOC

3 Residential Exposure = Inhalation Exposure.

4 Total Exposure = Avg Food & Water Exposure + Residential Exposure

. From Tables 3 and 4.

5Page 8 of 13



### Occupational Exposure and Risk Assessment

Occupational exposures and corresponding risks have not been evaluated for streptomycin since the completion of the Reregistration Eligibility Document in 1992. 2 

### Streptomycin use in agriculture and for ornamentals is typically for the control of various diseases such as blight, various rots and citrus canker. In this action, the Florida Department of Agricultu re and Consumer Services (FDACS) has asked for streptomycin use to be allowed on grapefruit in order to manage citrus canker at an application rate of 0.448 lb streptomycin per acre per application with an allowable seasonal use of 0.896 lb streptomycin pe r acre (i.e., 2 applications per season). FDACS also specified that applications are to be by ground equipment only and no applications are to occur via chemigation. A restricted entry interval (REI) of 12 hours and a 21

- day PHI

we re specified in the pet ition (however, a 60

- day PHI is being recommended by HED as previously discussed) . Handlers are required to wear normal work clothing, chemical resistant gloves and footwear, and a dust/mist respirator (i.e., PF=5 respirator). The label associated with

t his section 18 action is for Firewall 17WP Fungicide/Bactericide (EPA Reg 80990

- 4) which is a wettable powder formulation containing 22.4 percent streptomycin available in normal packaging (i.e., it does not appear to be sold in water soluble packets).

In occupational exposure and risk assessments for pesticides both handler and post

- application exposures are considered. Dermal exposures are considered for both and inhalation exposures are considered only for handlers. As there is no dermal endpoint as sociated with streptomycin, only inhalation exposures for handlers have been calculated. The inputs and algorithms used as the basis of these calculations have been recently updated. 3 

### The hazard aspects of the assessment

are similar to those described ab ove for the residential risk assessment. Risks (MOEs) have been calculated for the scenarios that would be expected to be associated with common applications to citrus in Florida such as airblast application to orchards. At the current level of protective equipment specified in the proposed streptomycin label (i.e., PF

- 5 respirator) risks are not a concern for all scenarios considered (i.e., MOEs exceed 100 in all circumstances).

Table 7

. Occupational Handler Risk from Mixing/Loading/Application of Streptomycin

Exposure Scenario Crop or Target Application Rate Amount

Handled

or Area

Treated INHALATION MOE

[Values are rounded, R=Respirator]

Worker Activity Form. Application

Equipment Application

Type No

- R PF5 R PF10 R EC

M/L WP Airblast Broadcast Orchard (e.g., apples, grapes) 0.448 lb ai/acre 40 acres 520 2600 5200 93000

Applicat

or Spray Airblast Broadcast Orchard (e.g., apples, grapes) 0.448 lb ai/acre 40 acres 4700 24000 47000 330000

M/L/A WP Mechanicall

y

- pressurized Handgun Broadcast

(foliar) Orchard

(e.g., apples, grapes) 0.000747 lb ai/gal 1000 gal 140000 690000 1400000 No Data

2 http://www.epa.gov/oppsrrd1/REDs/old_reds/strep_sulfate.pdf

3 http://www.epa.gov/pesticides/science/handler

- exposure

- data.html , includes both the algorithms and the

recommende d input parameters for risk assessment purposes.Page 9 of 13



### Appendix A. Tolerance established for grapefruit by using the OECD Calculator.

Streptomycin

Grapefruit

USA (CA, TX and FL)
2 Single Appl of 0.448 lb ai/A, 21

- day RTI, 60

- day PHI

Total number of data (n) 8

Percentage of censored data 0%

Number of non

- censored data 8

Lowest residue 0.010

Highest residue 0.072

Median residue 0.036

Mean 0.038

Standard deviation (SD) 0.022

Correction factor for censoring (CF) 1.000

Proposed MRL estimate

- Highest residue 0.072

- Mean + 4 SD 0.126

- CF x 3 Mean 0.115

Unrounded MRL 0.126

Rounded MRL 0.15Page 10 of 13



### Appendix B. Chronic Food Residue Input file.

Filename: F: \ Dietary Assessments \ Streptomycin \ ChronicFood&SurfaceWater_2012.R98 Chemical: Streptomycin RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 5 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/da y Date created/last modified: 05

- 22

- 2012/19:05:47/8 Program ver. 2.03
Comment: Emergency exception for grapefruit (0.15 ppm). Chronic run incorporating default processing factors.

------------------------------------------------------------------ -------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 1100 0070 11 Apple, fruit with peel 0.250000 1.000 1.000 11000080 11 Apple, peeled fruit 0.250000 1.000 1.000 11000081 11 Apple, peeled fruit

- babyfood 0.250000 1.000 1.000 11000090 11 Apple, dried 0.250000 8.000 1.000 11000091 11 Apple, dried

- babyfood 0.250000 8.000 1.000 11000100 11 Apple, juice 0.250000 1.300 1.000 11000101 11 Apple, juice

- baby food 0.250000 1.300 1.000 11000110 11 Apple, sauce 0.250000 1.000 1.000 11000111 11 Apple, sauce

- babyfood 0.250000 1.000 1.000
06030300 6C Bean, black, seed 0.500000 1. 000 1.000
06020310 6B Bean, broad, succulent 0.500000 1.000 1.000
06030320 6C Bean, broad, seed 0.500000 1.000 1.000 06020330 6B Bean, cowpea, succulent 0.500000 1.000 1.000

06030340 6C Bean , cowpea, seed 0.500000 1.000 1.000 06030350 6C Bean, great northern, seed 0.500000 1.000 1.000 06030360 6C Bean, kidney, seed 0.500000 1.000 1.000
06020370 6B Bean, lima, succulent 0.500000 1.000 1.000
06030380 6C Bean, lima, seed 0.500000 1.000 1.000 06030390 6C Bean, mung, seed 0.500000 1.000 1.000 06030400 6C Bean, navy, seed 0.500000 1.000 1.000

06030 410 6C Bean, pink, seed 0.500000 1.000 1.000 06030420 6C Bean, pinto, seed 0.500000 1.000 1.000 06010430 6A Bean, snap, succulent 0.500000 1.000 1.000 06010431 6A Bean, snap, succulent

- babyfood 0.500000 1.000 1.000 04020850 4B Celery 0.250000 1.000 1.000 04020851 4B Celery

- babyfood 0.250000 1.000 1.000 04020860 4B Celery, juice 0.250000 1.000 1.000 11001290 11 Crabapple 0.250000 1.000 1.000 10001800 10 Grapefruit 0.150000 1.000 1.000 10001810 10 Grapefruit, juice 0.150000 1.000 1.000 11002100 11 Loquat 0.250000 1.000 1.000

11002660 11 Pear 0.250000 1.000 1.000

11002661 11 Pear

- babyfood 0.250000 1.000 1.000
11002670 11 Pear, dried 0.250000 6.250 1.000 11002680 11 Pear, juice 0.250000 1.000 1.000 11002681 11 Pear, juice

- babyfood 0.250000 1.000 1.000 08002700 8 Pepper, bell 0.250000 1. 000 1.000 08002701 8 Pepper, bell

- babyfood 0.250000 1.000 1.000 08002710 8 Pepper, bell, dried 0.250000 1.000 1.000 08002711 8 Pepper, bell, dried

- babyfood 0.250000 1.000 1.000 08002720 8 Pepp er, nonbell 0.250000 1.000 1.000 08002721 8 Pepper, nonbell

- babyfood 0.250000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.250000 1.000 1.000 19022740 19B Pepper, black and white 0.250000 1.000 1.000 19022741 19B Pepper, black and white

- babyfood 0.250000 1.000 1.000 01032960 1C Potato, chips 0.250000 1.000 1.000 01032970 1C Potato, dry (granules/ flakes) 0.250000 6.500 1.000

01032 971 1C Potato, dry (granules/ flakes)

- b 0.250000 6.500 1.000
01032980 1C Potato, flour 0.250000 1.000 1.000
01032981 1C Potato, flour

- babyfood 0.250000 1.000 1.000 01032990 1C Potato, tuber, w/peel 0.250000 1.000 1.000 01032991 1C Potato, tuber, w/peel

- babyfood 0.250000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.250000 1.000 1.000 01033001 1C Potato, tuber, w/o peel

- babyfood 0.250000 1.000 1.000Page 11 of 13 11003100 11 Quince 0.250000 1.000 1.000

08003750 8 Tomato 0.250000 1.000 1.000

08003751 8 Tomato

- babyfood 0.250000 1.000 1.000 08003760 8 Tomato, p aste 0.250000 5.400 1.000 08003761 8 Tomato, paste

- babyfood 0.250000 5.400 1.000 08003770 8 Tomato, puree 0.250000 3.300 1.000 08003771 8 Tomato, puree

- babyfood 0.250000 3.300 1.000
08003780 8 Tomato, dried 0.250000 14.300 1.000
08003781 8 Tomato, dried

- babyfood 0.250000 14.300 1.000 08003790 8 Tomato, juice 0.250000 1.500 1.000
95003800 O Tomato, Tree 0.250000 1.000 1.000
86010000 O Water, direct, all sources 0.051400 1.000 1.000
86020000 O Water, indirect, all sources 0.051400 1. 000 1.000Page 12 of 13



### Appendix C. Chronic Results file.

U.S. Environmental Protection Agency Ver. 2.00

DEEM

- FCID Chronic analysis for STREPTOMYCIN (1994

- 98 data)

Residue file name: F: \ Dietary Assessments \ Streptomycin \ ChronicFood&SurfaceWater_2012.R98 Adjustment factor #2 NOT used.
Analysis Date 05

- 22

- 2012/19:07:20 Residue file dated: 05

- 22

- 2012/19:05:47/8
Reference dose (RfD, Chronic) = .05 m g/kg bw/day
COMMENT 1: Emergency exception for grapefruit (0.15 ppm). Chronic run incorporating default processing factors.

=============================================================================== Total exposure by population sub group

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.002303 4.6%

U.S. Population (spring season) 0.002270 4.5% U.S. Population (summer season) 0.002330 4.7% U.S. Population (autumn season) 0.002314 4.6% U.S. Population (winter season) 0.002297 4.6%

Northeast region 0.002237 4.5% Midwest region 0.002348 4.7% Southern region 0.002201 4.4% Western region 0.002477 5.0%

Hispanics 0.002680 5.4%

Non

- hispanic whites 0.0022 41 4.5%

Non

- hispanic blacks 0.002243 4.5%

Non

- hisp/non

- white/non

- black 0.002600 5.2%

All infants (< 1 year) 0.006393 12.8% Nursing i nfants 0.002861 5.7%

Non

- nursing infants 0.007733 15.5%

Children 1

- 6 yrs 0.005266 10.5%

Children 7

- 12 yrs 0.002561 5.1%

Females 13

- 19 (not preg or nursing) 0.001761 3.5% Females 20+ (not preg or nursing) 0.001865 3.7%

Females 13

- 50 yrs 0.001975 3.9% Females 13+ (preg/not nursing) 0.002056 4.1%
Females 13+ (nursing) 0.002450 4.9%

Males 13

- 19 yrs 0.001828 3.7% Males 20+ yrs 0.001848 3.7%

Seniors 55+ 0.001882 3.8%

Children 1

- 2 yrs 0.006486 13.0%

Children 3

- 5 yrs 0.004926 9.9%

Children 6

- 12 yrs 0.002756 5.5%

Youth 13

- 19 yrs 0.001797 3.6%

Adults 20

- 49 yrs 0.001853 3.7% Adults 50+ yrs 0.001879 3.8%

Females 13

- 49 yrs 0.001832 3.7%

-------------------------------------------------------------------------------Page 13 of 13



### Appendix D. International Residue Limits

Stre ptomycin (PC Code 006306) Streptomycin Sulfate (PC Code 006310)

Summary of US and International Tolerances and Maximum Residue Limits



### Residue Definition:

US Canada Mexico 2 

### Codex 3



### 40 CFR 180.441: Plants (commodities in this action):

Tolerances are established for residues of the fungicide streptomycin in or on food

commodities as follows: 

### None

Commodity 1 

### Tolerance (ppm) /Maximum Residue Limit (mg/kg)

US Canada Mexico 2 

### Codex 3



### Grapefruit 0.15 Grapefruit, dried pulp 0.40

Completed: M. Negussie; 0 7 / 12 /2012

1 Includes only commodities of interest for this action. Tolerance values should be the HED recommendations and not those proposed by the applicant.

2 Mexico adopts US tolerances and/or Codex MRLs for its export purposes.

3 * = absent at the limit of quantitation; Po = postharvest treatment, such as treatment of stored grains. PoP = processed postharvest treated commodity, such as processing of treated stored wheat. (fat) = to be measured on the fat portion of th e sample. MRLs indicated as proposed have not been finalized by the CCPR and the CAC.