Contents

Volume 105, Supplement 5, September 1997

Toxicology of Natural and Man-Made Fibrous
and Non-Fibrous Particles

- 1001

Giinter Oberdérster and Kevin E. Driscoll

Physical and Chemical Properties of Particles/Mechanisms of Toxicity
Mineral Properties and Their Contributions to Particle Toxicity ..
George D. Guthrie Jr.
Surface Reactivity in the Pathogenic Response to Particulates
Bice Fubini
‘Chemical Characterization and Reactivity of Iron Chelator-treated Amphibole Asbestos ..
Julie Gold, Helena Amandusson, Anatol Krozer, Bengt Kasemo, Tore Ericsson, Giovanna Zanetti, and Bice Fubini
Study of the Stability of a Paramagnetic Label Linked to Mesoporous Silica Surface in Contact with Rat Mesothelial

. 1003

1013

. 1021

Cells in Culture . 1031
Laura Mollo, 0p Bice Fubini
Demonstration of Nitric Oxide on Asbestos and Silicon Carbide Fibers with a New Ultraviolet Spectrophotometric Assay... 1037

Per Leanderson, Verner Lagesson, and Christer Tagesson
Can Microwave Radiation at High Temperatures Reduce the Toxicity of Fibrous Crocidolite Asbestos? ..
Mairam Gulumian, Zolani L. Nkosibomvu, Kalavati Channa, and Herman Pollak
Significance of the Biodurability of Man-made Vitreous Fibers to Risk Assessment ...
Hartwig Muble and Bernd Bellman
Investigations on Health-related Properties of Two Sepiolite Samples
Bernd Bellmann, Hartwig Muble, and Heinrich Ernst
Bioavailable Transition Metals in Particulate Matter Mediate Cardiopulmonary Injury in Healthy and
Compromised Animal Models .
Daniel L. Costa and Kevin L. Dreher

1041

- 1045

. 1049

- 1053

Carcinogenesis and Genotoxicity

Oncogenes and Tumor-Suppressor Genes in Mesothelioma—A Synopsis ....
Jobn F. Lechner, Johannes Tesfaigzi, and Brenda I. Gerwin

Susceptibility of p53-deficient Mice to Induction of Mesothelioma by Crocidolite Asbestos Fibers ...
Jean M. Marsella, Brenda L. Liu, Charles A. Vaslet, and Agnes B. Kane

Mechanisms of Fiber-induced Genotoxicity ...
‘Marie-Claude Jaurand

Malignant Transformation of Immortalized Human Bronchial Epithelial Cells by Asbestos Fibers
Tom K. Hei, Li J. Wu, and Chang Q. Piao

Neutrophils Amplify the Formation of DNA Adducts by Benzo[a]pyrene in Lung Target Cells
Paul J.A. Borm, Ad M. Knaapen, Roel P.F. Schins, Roger W.L. Godschalk, and Frederik-Jan Van Schooten

‘A New Mechanism for DNA Alterations Induced by Alpha Particles Such as Those Emitted by Radon and Radon Progeny
Bruce E. Lehnert and Edwin H. Goodwin

Fiber-specific Molecular Features of Tumors Induced in Rat Peritoneum ...
Klaus Unfried, Markus Roller, Friedrich Pott, Johannes Friemann, and Walter Debnen

Mechanism of Asbestos-mediated DNA Damage: Role of Heme and Heme Proteins ...
Qumar Rahman, Nayyara Mahmood, Sikander G. Khan, Jamal M. Arif, and Mohammad Athar

Asbestos, Asbestosis, and Lung Cancer: Observations in Quebec Chrysotile Workers ...
Bruce W. Case and André Dufresne

- 1061

. 1069

-- 1073

.- 1085

.- 1089

1095

.- 1103

. 1109

~ 1113

Intracellular Signaling Pathways

Cell Signaling Pathways Elicited by Asbestos ....
Brooke T. Mossman, Steven Faux, Yoonne Janssen, Luis A. Jimenez, Cynthia Timblin, Christine Zanella, Jonathan Goldberg,
Eric Walsh, Aaron Barchowsky, and Kevin Driscoll

» 1121



Possible Role of Lipid Peroxidation in the Induction of NF-KB and AP-1 in RFL-6 Cells by Crocidolite Asbesto:

Evidence following Protection by Vitamin E .... 1127
Stephen P. Faux and Peter J. Howden

Increased Focal Adhesion Kinase- and Urokinase-type Plasminogen Activator Receptor-associated Cell Signaling

in Endothelial Cells Exposed to Asbestos ... . 1131

‘A. Barchowsky, B.M. Lannon, L.C. Elmore, and M.D. Treadwell

Asbestos and Silica-induced Changes in Human Alveolar Macrophage Phenotype .....
Andrij Holian, Margaret O. Uthman, Tatiana Goltsova, Steven D. Brown, and Raymond F. Hamilton Jr.

(p53, Cip1, and Gadd 153 Expression following Treatment of A549 Cells with Natural and Man-made Vitreous Fibers ....
Neil F. Johnson and Richard J. Jaramillo

Crocidolite Asbestos Induces Apoptosis of Pleural Mesothelial Cells: Role of Reactive Oxygen Species and

Poly(ADP-ribosyl) Polymerase ....
V. Courtney Broaddus, Lin Yang, Louis M. Scavo, Joel D. Ernst, and Alice M. Boylan

Alterations in Protein Glycosylation in PMA-differentiated U-937 Cells Exposed to Mineral Particles ....
Nourredine Trabelsi, Anne Greffard, Jean-Claude Pairon, Jean Bignon, Giovanna Zanetti, Bice Fubini, and Yannick Pilatte

. 1139

.- 1143

. 1147

. 1153

Cytokines/Immune Mechanisms

Cytokines and Particle-induced Inflammatory Cell Recruitment ..
Kevin E. Driscoll, Janet M. Carter, Diana G. Hassenbein, and Brian Howard

‘Analyzing the Genes and Peptide Growth Factors Expressed in Lung Cells in Vivo Consequent to Asbestos Exposure

and in Vitro .....
Arnold R. Brody, Jing-Yao Liu, David Brass, and Miriam Corti

Effects of Mineral Fibers on the Expression of Genes Whose Product May Play a Role in Fiber Pathogenesis .
Tohru Tsuda, Yasuo Morimoto, Hiroshi Yamato, Hiromi Nakamura, Hajime Hori, Nobuhiko Nagata, Masamitsu Kido,
Toshiaki Higashi, and Isamu Tanaka

Particulate-Cell Interactions and Pulmonary Cytokine Expression ..
Jacob N. Finkelstein, Carl Johnston, Ted Barrett, and Ginter Oberdarster

Localization of Intercellular Adhesion Molecule-1 (ICAM-1) in the Lungs of Silica-exposed Mice ....
Ricardo C. Nario and Andrea K. Hubbard

. 1159

- 1165

. 1173

- 1179

.- 1183

Alveolar Macrophage Interaction with Air Pollution Particulates .. . 1191
Carroll-Ann Goldsmith, Charles Frevert, Amy Imrich, Constantinos Sioutas, and Lester Kobzik

Immunohistochemical Localization of Transforming Growth Factor Beta Isoforms in Asbestos-related Diseases .... .. 1197
Jaishree Jagirdar, Theodore C. Lee, Joan Reibman, Leslie I. Gold, Christopher Aston, Raymond Bégin, and William N. Rom

Models/Mechanisms

Early Mesothelial Cell Proliferation after Asbestos Exposure: In Vivo and in Vitro Studies . 1205
Tan Y.R. Adamson

Comparison of Pleural Responses of Rats and Hamsters to Subchronic Inhalation of Refractory Ceramic Fibers ... .. 1209

Jeffiey I. Everitt, Thomas R. Geleleichter, Edilberto Bermudez, James B. Mangum, Brian A. Wong, Derek B. Janszen, and
Owen R. Moss

Mechanisms of Mineral Dust-induced Emphysema .... 1215
‘Andrew Churg, Katalin Zay, and Kevin Li

Lung Proliferative and Clearance Responses to Inhaled para-Aramid REP in Exposed Hamsters and Rats:

Comparisons with Chrysotile Asbestos Fibers .. .. 1219

David B. Warheit, Suzanne I. Snajdr, Mark A. Hartsky, and Steven R. Frame
Chronic Inhalation Study of Fiber Glass and Amosite Asbestos in Hamsters: Twelve-month Preliminary Results . -
T.W. Hesterberg, C. Axten, E.E. McConnell, G. Oberdérster, J. Everitt, W.C. Miiller, J. Chevalier, G.R. Chase, and P. Thevenaz
Sites of Particle Retention and Lung Tissue Responses to Chronically Inhaled Diesel Exhaust and Coal Dust in Rats

.. 1223

and Cynomolgus Monkeys .. . 1231
Kristen J. Nikula, Kelly J. Avila, William C. Griffith, and Joe L. Mauderly

Short-term Inhalation and in Vitro Tests as Predictors of Fiber Pathogenicity .. .. 1235
Richard Thomas Cullen, Brian George Miller, John Michael Gordon Davis, David McAllister Brown, and Kenneth Donaldson

Silica-induced Apoptosis in Alveolar and Granulomatous Cells in Vivo .. .. 1241

James Leigh, He Wang, Antonio Bonin, Matthew Peters, and Xiuyao Ruan
Expression of Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases, and Extracellular Matrix mRNA
following Exposure to Mineral Fibers and Cigarette Smoke in Vivo
Yasuo Morimoto, Tohru Tsuda, Hiromi Nakamura, Hajime Hori, Hiroshi
Masamitsu Kido, and Isamu Tanaka

.. 1247

Yamato, Nobuhiko Nagata, Toshiaki Higashi,


Dose-Response Relationship of Fibrous Dusts in Intraperitoneal Studies ...
Markus Roller, Friedrich Pott, Kenji Kamino, Gerhard-Heinrich Alchoff, and Bernd Bellman

Pleural Macrophage Recruitment and Activation in Asbestos-induced Pleural Injury .
Nonghoon Choe, Shogo Tanaka, Weijia Xia, David R. Hemenway, Victor L. Roggli, an

Cell Size of Alveolar Macrophages: An Interspecies Comparison
Fritz Krombach, Silvia Miinzing, Anne-Marie Allmeling, J. Tilman Gerlach, Jiirgen Bebr, and Martina D

Intratracheal Instillation versus Intratracheal Inhalation: Influence of Cytokines on Inflammatory Response ...
M. Osier, RB. Baggs, and G. Oberdorster

Oxidative Stress

Efflux of Reduced Glutathione after Exposure of Human Lung Epithelial Cells to Crocidolite Asbestos ....
Scott A. Golladay, Sun-Hee Park, and Ann E. Aust

In Vivo and in Vitro Proinflammatory Effects of Particulate Air Pollution (PMjo)
XY. Li, P.S. Gilmour, K. Donaldson, and W. MacNee

Free Radical Activity of PMjo: Iron-mediated Generation of Hydroxyl Radicals
Kenneth Donaldion, David M. Brown, Colin Mitchell, Miglna Dineva, Paul H. Beswid

Formation and Persistence of 8-Oxoguanine in Rat Lung Cells as an Important Determinant for Tumor Formation

following Particle Exposure
Peter Nebls, Frank Seiler, Bernd Rehn, Ruth Greferath, and Joachim Bruch

Expression of Inducible Nitric Oxide Synthase and Formation of Nitric Oxide by Alveolar Macrophages:

‘An Interspecies Comparison .
Natalie K. Jesch, Martina Dorger, Georg Enders, Gabriele Rieder, Claus Vogelmeier, Konrad Messmer, and Fritz Krombach

The Role of Reactive Oxygen and Nitrogen Species in the Response of Airway Epithelium to Particulates ...
Linda D. Martin, Thomas M. Krunkosky, Janice A. Dye, Bernard M. Fischer, Nan Fei Jiang, Lori G. Rochelle, Nancy J. Akley,
Kevin L. Dreher, and Kenneth B. Adler

Interspecies Comparison of Rat and Hamster Alveolar Macrophage Antioxidative and Oxidative Capacity ...
Martina Dorger, Anne-Marie Allmeling, Ariane Neuber, Jiirgen Behr, Walter Rambeck, and Fritz Krombach

Free Radical Activity of Industrial Fibers: Role of Iron in Oxidative Stress and Activation of Transcription Factors ......
Peter S. Gilmour, David M, Brown, Paul H. Beswick, William MacNee, Irfan Rahman, and Kenneth Donaldson

‘Augmentation of Pulmonary Reactions to Quartz Inhalation by Trace Amounts of Iron-containing Particles ..
Vincent Castranova, Val Vallyathan, Dawn M. Ramsey, Jeffrey L. McLaurin, Donna Pack, Steven Leonard, Mark W. Barger,
Jane Y.C. Ma, Nar S. Dalal, and Alex Teass

Involvement of Protein Kinase C, Phospholipase C, and Protein Tyrosine Kinase Pathways in Oxygen Radical Generation

. 1297

. 1301

.- 1309

.- 1313

.. 1319

by Asbestos-stimulated Alveolar Macrophage .... .. 1325
Young Lim, Sun-Hyung Kim, Kyoung-Ah Kim, Min-Wha Oh, and Kweon-Haeng Lee

Approaches to Safety Evaluation and Risk Assessment

Approaches to Characterizing Human Health Risks of Exposure to Fibers . 1329

Vanessa T. Vu and David Y. Lai

Relevance of Particle-induced Rat Lung Tumors for Assessing Lung Carcinogenic Hazard and Human Lung Cancer Risk ........ 1337
Joe L. Mauderly

Puimonary Carcinogenicity of Inhaled Particles and the Maximum Tolerated Dose
G. Oberdérster

Strategies for Setting Occupational Exposure Limits for Particles
Helmut A. Greim and Kyriakoula Ziegler-Skylakakis

Use of Mechanistic Data in Assessing Human Risks from Exposure to Particles ....
Roger O. McClellan

Editorial Committee for the Sixth International Meeting on the Toxicology of Natural and Man-Made Fibrous

.» 1347

.. 1357

1363

and Non-Fibrous Particles .... . 1373
Editorial Policy ... . 1375
Instructions to Authors ..... a» 1376
Subscription Information .. 1378
Published Volumes of EHP Supplements .. 1380