[Federal Register Volume 75, Number 235 (Wednesday, December 8, 2010)]
[Notices]
[Pages 76460-76461]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2010-30848]


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ENVIRONMENTAL PROTECTION AGENCY

[FRL-9236-6; Docket ID No. EPA-HQ-ORD-2010-0991]


Lymphohematopoietic Cancers Induced by Chemicals and Other 
Agents: Overview and Implications for Risk Assessment

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice of public comment period.

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SUMMARY: EPA is announcing a 45-day public comment period for the draft 
document titled, ``Lymphohematopoietic Cancers Induced by Chemicals and 
Other Agents: Overview and Implications for Risk Assessment'' (EPA/600/
R-10/095A). The draft document was prepared by the National Center for 
Environmental Assessment within EPA's Office of Research and 
Development. The draft document provides an overview of the types and 
mechanisms underlying the lymphohematopoietic cancers induced by 
chemical agents and radiation in humans, with a primary emphasis on 
leukemia and leukemia-inducing agents. In addition, the document also 
focuses on how mechanistic information on human leukemia-inducing 
agents can inform risk assessment.
    EPA is releasing this draft document solely for the purpose of pre-
dissemination peer review under applicable information quality 
guidelines. This draft document has not been formally disseminated by 
EPA. It does not represent and should not be construed to represent any 
Agency policy or determination. All public comments received will be 
provided to the peer reviewers at the beginning of the review process.

DATES: The 45-day public comment period begins December 8, 2010, and 
ends January 24, 2011. Technical comments should be in writing and must 
be received by EPA by January 24, 2011.

ADDRESSES: The draft ``Lymphohematopoietic Cancers Induced by Chemicals 
and Other Agents: Overview and Implications for Risk Assessment'' is 
available primarily via the Internet on the National Center for 
Environmental Assessment's home page under the Recent Additions and the 
Data and Publications menus at http://www.epa.gov/ncea. A limited 
number of paper copies are available from the Information Management 
Team, NCEA; telephone: 703-347-8561; facsimile: 703-347-8691. If you 
are requesting a paper copy, please provide your name, your mailing 
address, and the draft document title, ``Lymphohematopoietic Cancers 
Induced by Chemicals and Other Agents: Overview and Implications for 
Risk Assessment.''
    Comments may be submitted electronically via http://www.regulations.gov, by mail, by facsimile, or by hand delivery/
courier. Please follow the detailed instructions provided in the 
SUPPLEMENTARY INFORMATION section of this notice.

FOR FURTHER INFORMATION CONTACT: For information on the public comment 
period, contact the Office of Environmental Information Docket; 
telephone: 202-566-1752; facsimile: 202-566-1753; or e-mail: 
<a href="/cdn-cgi/l/email-protection#246b76600a604b474f4150644154450a434b52"><span class="__cf_email__" data-cfemail="fdb2afb9d3b9929e969889bd988d9cd39a928b">[email protected]</span></a>.
    For technical information, contact Nagu Keshava, NCEA; telephone: 
919-541-3047; facsimile: 919-541-0245; or e-mail: <a href="/cdn-cgi/l/email-protection#640f01170c0512054a0a050311240114054a030b12"><span class="__cf_email__" data-cfemail="d8b3bdabb0b9aeb9f6b6b9bfad98bda8b9f6bfb7ae">[email protected]</span></a>.

SUPPLEMENTARY INFORMATION:

I. Information About the Project/Document

    This project was initiated to better understand the mechanisms 
underlying the lymphohematopoietic cancers induced by chemical agents 
in humans. A draft report was developed that provides an overview of 
types and mechanisms underlying the lymphohematopoietic cancers induced 
by both chemical agents and radiation in humans, with a primary 
emphasis on leukemia and leukemia-inducing agents.

II. How to Submit Technical Comments to the Docket at http://www.regulations.gov

    Submit your comments, identified by Docket ID No. EPA-HQ-ORD-2010-
0991, by one of the following methods:
    <bullet> http://www.regulations.gov: Follow the on-line 
instructions for submitting comments.
    <bullet> E-mail: <a href="/cdn-cgi/l/email-protection#49061b0d670d262a222c3d092c3928672e263f"><span class="__cf_email__" data-cfemail="86c9d4c2a8c2e9e5ede3f2c6e3f6e7a8e1e9f0">[email protected]</span></a>.
    <bullet> Fax: 202-566-1753.
    <bullet> Mail: Office of Environmental Information (OEI) Docket 
(Mail Code: 2822T), U.S. Environmental Protection Agency, 1200 
Pennsylvania Ave., NW., Washington, DC 20460. The phone number is 202-
566-1752.
    <bullet> Hand Delivery: The OEI Docket is located in the EPA 
Headquarters Docket

[[Page 76461]]

Center, Room 3334 EPA West Building, 1301 Constitution Ave., NW., 
Washington, DC. The EPA Docket Center Public Reading Room is open from 
8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal 
holidays. The telephone number for the Public Reading Room is 202-566-
1744. Such deliveries are only accepted during the docket's normal 
hours of operation, and special arrangements should be made for 
deliveries of boxed information. If you provide comments by mail or 
hand delivery, please submit three copies of the comments. For 
attachments, provide an index, number pages consecutively with the 
comments, and submit an unbound original and three copies.
    Instructions: Direct your comments to Docket ID No. EPA-HQ-ORD-
2010-0991. Please ensure that your comments are submitted within the 
specified comment period. Comments received after the closing date will 
be marked ``late,'' and may only be considered if time permits. It is 
EPA's policy to include all comments it receives in the public docket 
without change and to make the comments available online at http://www.regulations.gov, including any personal information provided, 
unless a comment includes information claimed to be Confidential 
Business Information (CBI) or other information whose disclosure is 
restricted by statute. Do not submit information that you consider to 
be CBI or otherwise protected through http://www.regulations.gov or e-
mail. The http://www.regulations.gov Web site is an ``anonymous 
access'' system, which means EPA will not know your identity or contact 
information unless you provide it in the body of your comment. If you 
send an e-mail comment directly to EPA without going through http://www.regulations.gov, your e-mail address will be automatically captured 
and included as part of the comment that is placed in the public docket 
and made available on the Internet. If you submit an electronic 
comment, EPA recommends that you include your name and other contact 
information in the body of your comment and with any disk or CD-ROM you 
submit. If EPA cannot read your comment due to technical difficulties 
and cannot contact you for clarification, EPA may not be able to 
consider your comment. Electronic files should avoid the use of special 
characters, any form of encryption, and be free of any defects or 
viruses. For additional information about EPA's public docket visit the 
EPA Docket Center homepage at http://www.epa.gov/epahome/dockets.htm.
    Docket: Documents in the docket are listed in the http://www.regulations.gov index. Although listed in the index, some 
information is not publicly available, e.g., CBI or other information 
whose disclosure is restricted by statute. Certain other materials, 
such as copyrighted material, are publicly available only in hard copy. 
Publicly available docket materials are available either electronically 
in http://www.regulations.gov or in hard copy at the OEI Docket in the 
EPA Headquarters Docket Center.

    Dated: December 2, 2010.
Darrell A. Winner,
Acting Director, National Center for Environmental Assessment.
[FR Doc. 2010-30848 Filed 12-7-10; 8:45 am]
BILLING CODE 6560-50-P


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