Federal Register / Vol. 75, No. 235 / Wednesday, December 8, 2010 / Notices 76457 

part of the EPA registration numbers of 

the products listed above. 

TABLE 2—REGISTRANTS OF

METHOMYL PRODUCTS

EPA company 

No. Company name and address 

000352 ........... E.I. du Pont de Nemours 

and Company DuPont 

Crop Protection, StineHaskell Research Center, 

P.O. Box 30, Newark, DE 

19714–0030. 

III. Summary of Public Comments 

Received and Agency Response to 

Comments 

On April 14, 2008, during the public 

comment period the registrant withdrew 

the voluntary cancellation of the grape 

use and submitted a PRIA action 

consisting of a change in the use of 

methomyl on grapes along with grape 

residue monitoring data provided by 

grape growers. While this new 

information refined the dietary 

assessment, it was not sufficient to 

change the Agency’s previous 

conclusion. As a result, the registrant 

withdrew the PRIA action on April 9, 

2010. For this reason, the Agency does 

not believe that the information 

submitted during the comment period 

merits further review or a denial of the 

requests for voluntary use deletion. 

IV. Cancellation Order 

Pursuant to FIFRA section 6(f), EPA 

hereby approves the requested 

amendments to terminate uses of 

methomyl registrations identified in 

Table 1 of Unit II. Accordingly, the 

Agency hereby orders that the product 

registrations identified in Table 1 of 

Unit II. are amended to terminate the 

affected use. The effective date of the 

cancellations that are the subject of this 

notice is December 8, 2010. Any 

distribution, sale, or use of existing 

stocks of the products identified in 

Table 1 of Unit II. in a manner 

inconsistent with any of the provisions 

for disposition of existing stocks set 

forth in Unit VI. will be a violation of 

FIFRA. 

V. What is the Agency’s authority for 

taking this action? 

Section 6(f)(1) of FIFRA provides that 

a registrant of a pesticide product may 

at any time request that any of its 

pesticide registrations be canceled or 

amended to terminate one or more uses. 

FIFRA further provides that, before 

acting on the request, EPA must publish 

a notice of receipt of any such request 

in the Federal Register. Thereafter, 

following the public comment period, 

the EPA Administrator may approve 

such a request. The notice of receipt for 

this action was published for comment 

on October 24, 2007 (72 FR 60634) 

(FRL–8153–3). The comment period 

closed on April 21, 2008. 

VI. Provisions for Disposition of 

Existing Stocks 

Existing stocks are those stocks of 

registered pesticide products which are 

currently in the United States and 

which were packaged, labeled, and 

released for shipment prior to the 

effective date of the action. The existing 

stocks provision for the products subject 

to this order is as follows. 

Now that EPA has approved product 

labels reflecting the requested 

amendments to delete uses, registrants 

are permitted to sell or distribute 

products listed in Table 1 of Unit II. 

under the previously approved labeling 

until June 8, 2012, a period of 18 

months after publication of the 

cancellation order in this Federal 

Register, unless other restrictions have 

been imposed. Thereafter, registrants 

will be prohibited from selling or 

distributing the products whose labels 

include the deleted uses identified in 

Table 1 of Unit II., except for export 

consistent with FIFRA section 17 or for 

proper disposal. 

Persons other than the registrant may 

sell, distribute, or use existing stocks of 

products whose labels include the 

deleted uses until supplies are 

exhausted, provided that such sale, 

distribution, or use is consistent with 

the terms of the previously approved 

labeling on, or that accompanied, 

products with the deleted uses. 

List of Subjects 

Environmental protection, Pesticides 

and pests. 

Dated: December 2, 2010. 

Richard P. Keigwin, Jr., 

Director, Pesticide Re-evaluation Division, 

Office of Pesticide Programs. 

[FR Doc. 2010–30865 Filed 12–7–10; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

[EPA–HQ–OPP–2010–0588; FRL–8854–5] 

FIFRA Scientific Advisory Panel; 

Notice of Public Meeting 

AGENCY: Environmental Protection 

Agency. 

ACTION: Notice. 

SUMMARY: There will be a 4–day meeting 

of the Federal Insecticide, Fungicide, 

and Rodenticide Act Scientific Advisory 

Panel (FIFRA SAP) to consider and 

review the Chlorpyrifos PhysiologicallyBased Pharmacokinetic/ 

Pharmacodynamic (PBPK/PD) Modeling 

linked to the Cumulative and Aggregate 

Risk Evaluation System (CARES). 

DATES: The meeting will be held on 

February 15–18, 2011, from 9 a.m. to 

approximately 5:30 p.m. 

Comments. The Agency encourages 

that written comments be submitted by 

January 31, 2011 and requests for oral 

comments be submitted by February 8, 

2011. However, written comments and 

requests to make oral comments may be 

submitted until the date of the meeting, 

but anyone submitting written 

comments after January 31, 2011 should 

contact the Designated Federal Official 

(DFO) listed under FOR FURTHER

INFORMATION CONTACT. For additional 

instructions, see Unit I.C. of the 

SUPPLEMENTARY INFORMATION. 

Nominations. Nominations of 

candidates to serve as ad hoc members 

of FIFRA SAP for this meeting should 

be provided on or before December 22, 

2010. 

Webcast. This meeting may be 

webcast. Please refer to the FIFRA SAP’s 

Web site, http://www.epa.gov/scipoly/ 

SAP for information on how to access 

the webcast. Please note that the 

webcast is a supplementary public 

process provided only for convenience. 

If difficulties arise resulting in 

webcasting outages, the meeting will 

continue as planned. 

Special accommodations. For 

information on access or services for 

individuals with disabilities, and to 

request accommodation of a disability, 

please contact the DFO listed under FOR

FURTHER INFORMATION CONTACT at least 

10 days prior to the meeting to give EPA 

as much time as possible to process 

your request. 

ADDRESSES: The meeting will be held at 

the Environmental Protection Agency, 

Conference Center, Lobby Level, One 

Potomac Yard (South Bldg.), 2777 S. 

Crystal Dr., Arlington, VA 22202. 

Comments. Submit your comments, 

identified by docket identification (ID) 

number EPA–HQ–OPP–2010–0588, by 

one of the following methods: 

• Federal eRulemaking Portal: http:// 

www.regulations.gov. Follow the on-line 

instructions for submitting comments. 

• Mail: Office of Pesticide Programs 

(OPP) Regulatory Public Docket (7502P), 

Environmental Protection Agency, 1200 

Pennsylvania Ave., NW., Washington, 

DC 20460–0001. 

• Delivery: OPP Regulatory Public 

Docket (7502P), Environmental 

Protection Agency, Rm. S–4400, One 


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Potomac Yard (South Bldg.), 2777 S. 

Crystal Dr., Arlington, VA. Deliveries 

are only accepted during the Docket 

Facility’s normal hours of operation 

(8:30 a.m. to 4 p.m., Monday through 

Friday, excluding legal holidays). 

Special arrangements should be made 

for deliveries of boxed information. The 

Docket Facility telephone number is 

(703) 305–5805. 

Instructions: Direct your comments to 

docket ID number EPA–HQ–OPP–2010– 

0588. If your comments contain any 

information that you consider to be CBI 

or otherwise protected, please contact 

the DFO listed under FOR FURTHER

INFORMATION CONTACT, to obtain special 

instructions before submitting your 

comments. EPA’s policy is that all 

comments received will be included in 

the docket without change and may be 

made available on-line at http:// 

www.regulations.gov, including any 

personal information provided, unless 

the comment includes information 

claimed to be Confidential Business 

Information (CBI) or other information 

whose disclosure is restricted by statute. 

Do not submit information that you 

consider to be CBI or otherwise 

protected through regulations.gov or email. The regulations.gov Web site is an 

‘‘anonymous access’’ system, which 

means EPA will not know your identity 

or contact information unless you 

provide it in the body of your comment. 

If you send an e-mail comment directly 

to EPA without going through 

regulations.gov, your e-mail address 

will be automatically captured and 

included as part of the comment that is 

placed in the docket and made available 

on the Internet. If you submit an 

electronic comment, EPA recommends 

that you include your name and other 

contact information in the body of your 

comment and with any disk or CD–ROM 

you submit. If EPA cannot read your 

comment due to technical difficulties 

and cannot contact you for clarification, 

EPA may not be able to consider your 

comment. Electronic files should avoid 

the use of special characters, any form 

of encryption, and be free of any defects 

or viruses. 

Docket: All documents in the docket 

are listed in the docket index available 

at http://www.regulations.gov. 

Although, listed in the index, some 

information is not publicly available, 

e.g., CBI or other information whose 

disclosure is restricted by statute. 

Certain other material, such as 

copyrighted material, is not placed on 

the Internet and will be publicly 

available only in hard copy form. 

Publicly available docket materials are 

available either in the electronic docket 

at http://www.regulations.gov, or, if only 

available in hard copy, at the OPP 

Regulatory Public Docket in Rm. S– 

4400, One Potomac Yard (South Bldg.), 

2777 S. Crystal Dr., Arlington, VA. The 

hours of operation of this Docket 

Facility are from 8:30 a.m. to 4 p.m., 

Monday through Friday, excluding legal 

holidays. The Docket Facility telephone 

number is (703) 305–5805. 

Nominations, requests to present oral 

comments, and requests for special 

accommodations. Submit nominations 

to serve as ad hoc members of FIFRA 

SAP, requests for special seating 

accommodations, or requests to present 

oral comments to the DFO listed under 

FOR FURTHER INFORMATION CONTACT. 

FOR FURTHER INFORMATION CONTACT: 

Sharlene R. Matten, DFO, Office of 

Science Coordination and Policy 

(7201M), Environmental Protection 

Agency, 1200 Pennsylvania Ave., NW., 

Washington, DC 20460–0001; telephone 

number: (202) 564–0130; fax number: 

(202) 564–8382; e-mail address: 

matten.sharlene@epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. General Information 

A. Does this action apply to me? 

This action is directed to the public 

in general. This action may, however, be 

of interest to persons who are or may be 

required to conduct testing of chemical 

substances under the Federal Food, 

Drug, and Cosmetic Act (FFDCA), 

FIFRA, and the Food Quality Protection 

Act of 1996 (FQPA). Since other entities 

may also be interested, the Agency has 

not attempted to describe all the specific 

entities that may be affected by this 

action. If you have any questions 

regarding the applicability of this action 

to a particular entity, consult the DFO 

listed under FOR FURTHER INFORMATION

CONTACT. 

B. What should I consider as I prepare 

my comments for EPA? 

When submitting comments, 

remember to: 

1. Identify the document by docket ID 

number and other identifying 

information (subject heading, Federal 

Register date and page number). 

2. Follow directions. The Agency may 

ask you to respond to specific questions 

or organize comments by referencing a 

Code of Federal Regulations (CFR) part 

or section number. 

3. Explain why you agree or disagree; 

suggest alternatives and substitute 

language for your requested changes. 

4. Describe any assumptions and 

provide any technical information and/ 

or data that you used. 

5. If you estimate potential costs or 

burdens, explain how you arrived at 

your estimate in sufficient detail to 

allow for it to be reproduced. 

6. Provide specific examples to 

illustrate your concerns and suggest 

alternatives. 

7. Explain your views as clearly as 

possible, avoiding the use of profanity 

or personal threats. 

8. Make sure to submit your 

comments by the comment period 

deadline identified. 

C. How may I participate in this 

meeting? 

You may participate in this meeting 

by following the instructions in this 

unit. To ensure proper receipt by EPA, 

it is imperative that you identify docket 

ID number EPA–HQ–OPP–2010–0588 in 

the subject line on the first page of your 

request. 

1. Written comments. The Agency 

encourages that written comments be 

submitted, using the instructions in 

ADDRESSES, no later than January 31, 

2011, to provide FIFRA SAP the time 

necessary to consider and review the 

written comments. Written comments 

are accepted until the date of the 

meeting, but anyone submitting written 

comments after January 31, 2011, 

should contact the DFO listed under FOR

FURTHER INFORMATION CONTACT. Anyone 

submitting written comments at the 

meeting should bring 30 copies for 

distribution to FIFRA SAP. 

2. Oral comments. The Agency 

encourages that each individual or 

group wishing to make brief oral 

comments to FIFRA SAP submit their 

request to the DFO listed under FOR

FURTHER INFORMATION CONTACT no later 

than February 8, 2011, in order to be 

included on the meeting agenda. 

Requests to present oral comments will 

be accepted until the date of the 

meeting, and to the extent that time 

permits, the Chair of FIFRA SAP may 

permit the presentation of oral 

comments at the meeting by interested 

persons who have not previously 

requested time. The request should 

identify the name of the individual 

making the presentation, the 

organization (if any) the individual will 

represent, and any requirements for 

audiovisual equipment (e.g., overhead 

projector, 35 mm projector, chalkboard). 

Oral comments before FIFRA SAP are 

limited to approximately 5 minutes 

unless prior arrangements have been 

made. In addition, each speaker should 

bring 30 copies of his or her comments 

and presentation slides for distribution 

to the FIFRA SAP at the meeting. 

3. Seating at the meeting. Seating at 

the meeting will be open and on a firstcome basis. 


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4. Request for nominations to serve as 

ad hoc members of FIFRA SAP for this 

meeting. As part of a broader process for 

developing a pool of candidates for each 

meeting, FIFRA SAP staff routinely 

solicits the stakeholder community for 

nominations of prospective candidates 

for service as ad hoc members of FIFRA 

SAP. Any interested person or 

organization may nominate qualified 

individuals to be considered as 

prospective candidates for a specific 

meeting. Individuals nominated for this 

meeting should have expertise in one or 

more of the following areas: Risk 

assessment, organophosphate 

pesticides, cholinesterase inhibition, 

data-derived uncertainty factors (also 

referred to as chemical-specific 

adjustment factors), pharmacodynamic 

modeling, physiologically-based 

pharmacokinetic modeling, 

biomonitoring data, statistical modeling, 

probabilistic techniques, and dietary 

exposure to pesticides. Nominees 

should be scientists who have sufficient 

professional qualifications, including 

training and experience, to be capable of 

providing expert comments on the 

scientific issues for this meeting. 

Nominees should be identified by name, 

occupation, position, address, and 

telephone number. Nominations should 

be provided to the DFO listed under FOR

FURTHER INFORMATION CONTACT on, or, 

before December 22, 2010. The Agency 

will consider all nominations of 

prospective candidates for this meeting 

that are received on or before this date. 

However, final selection of ad hoc 

members for this meeting is a 

discretionary function of the Agency. 

The selection of scientists to serve on 

FIFRA SAP is based on the function of 

the panel and the expertise needed to 

address the Agency’s charge to the 

panel. No interested scientists shall be 

ineligible to serve by reason of their 

membership on any other advisory 

committee to a Federal department or 

agency or their employment by a 

Federal department or agency except the 

EPA. Other factors considered during 

the selection process include 

availability of the potential panel 

member to fully participate in the 

panel’s reviews, absence of any conflicts 

of interest or appearance of lack of 

impartiality, independence with respect 

to the matters under review, and lack of 

bias. Although, financial conflicts of 

interest, the appearance of lack of 

impartiality, lack of independence, and 

bias may result in disqualification, the 

absence of such concerns does not 

assure that a candidate will be selected 

to serve on FIFRA SAP. Numerous 

qualified candidates are identified for 

each panel. Therefore, selection 

decisions involve carefully weighing a 

number of factors including the 

candidates’ areas of expertise and 

professional qualifications and 

achieving an overall balance of different 

scientific perspectives on the panel. In 

order to have the collective breadth of 

experience needed to address the 

Agency’s charge for this meeting, the 

Agency anticipates selecting 

approximately 10–15 ad hoc scientists. 

FIFRA SAP members are subject to 

the provisions of 5 CFR part 2634, 

Executive Branch Financial Disclosure, 

as supplemented by EPA in 5 CFR part 

6401. In anticipation of this 

requirement, prospective candidates for 

service on the FIFRA SAP will be asked 

to submit confidential financial 

information which shall fully disclose, 

among other financial interests, the 

candidate’s employment, stocks and 

bonds, and where applicable, sources of 

research support. EPA will evaluate the 

candidates financial disclosure form to 

assess whether there are financial 

conflicts of interest, appearance of a 

lack of impartiality or any prior 

involvement with the development of 

the documents under consideration 

(including previous scientific peer 

review) before the candidate is 

considered further for service on FIFRA 

SAP. Those who are selected from the 

pool of prospective candidates will be 

asked to attend the public meetings and 

to participate in the discussion of key 

issues and assumptions at these 

meetings. In addition, they will be asked 

to review and to help finalize the 

meeting minutes. The list of FIFRA SAP 

members participating at this meeting 

will be posted on the FIFRA SAP Web 

site at http://epa.gov/scipoly/sap, or 

may be obtained from the OPP 

Regulatory Public Docket at http:// 

www.regulations.gov. 

II. Background 

A. Purpose of FIFRA SAP 

FIFRA SAP serves as the primary 

scientific peer review mechanism of 

EPA’s Office of Chemical Safety and 

Pollution Prevention (OCSPP) and is 

structured to provide scientific advice, 

information and recommendations to 

the EPA Administrator on pesticides 

and pesticide-related issues as to the 

impact of regulatory actions on health 

and the environment. FIFRA SAP is a 

Federal advisory committee established 

in 1975 under FIFRA that operates in 

accordance with requirements of the 

Federal Advisory Committee Act. FIFRA 

SAP is composed of a permanent panel 

consisting of seven members who are 

appointed by the EPA Administrator 

from nominees provided by the National 

Institutes of Health and the National 

Science Foundation. FIFRA, as 

amended by the Food Quality Protection 

Act of 1996 (FQPA), established a 

Science Review Board consisting of at 

least 60 scientists who are available to 

the SAP on an ad hoc basis to assist in 

reviews conducted by the SAP. As a 

peer review mechanism, FIFRA SAP 

provides comments, evaluations and 

recommendations to improve the 

effectiveness and quality of analyses 

made by Agency scientists. Members of 

FIFRA SAP are scientists who have 

sufficient professional qualifications, 

including training and experience, to 

provide expert advice and 

recommendation to the Agency. 

B. Public Meeting 

Chlorpyrifos (0,0-diethyl-0-3,5,6- 

trichloro-2-pyridyl phosphorothioate) is 

a broad-spectrum, chlorinated 

organophosphate (OP) insecticide. In 

2000, nearly all residential uses were 

voluntarily cancelled by Dow 

AgroSciences, but agricultural uses 

remain. The 2000 human health risk 

assessment was largely based on adult 

laboratory animal data (rat or dog) for 

cholinesterase inhibition and the 

application of default uncertainty 

factors to address inter- and intraspecies differences including 

susceptible populations. Currently, the 

Agency is developing a new human 

health risk assessment expected to be 

released in 2011. In 2008, the FIFRA 

Scientific Advisory Panel (SAP) 

reviewed a draft science issue paper on 

the human health effects of chlorpyrifos. 

Since that time, Dow AgroSciences has 

undergone a research effort to improve 

the existing physiologically-based 

pharmacokinetic/pharmacodynamic 

model (PBPK/PD) developed by Dr. 

Charles Timchalk and co-workers at 

Pacific Northwest National Laboratory. 

Dow AgroSciences has also developed a 

proposed approach for merging this 

PBPK/PD model with CARES 

Cumulative and Aggregate Risk 

Evaluation System, see http:// 

www.ilsi.org/ResearchFoundation/ 

Pages/CARES.aspx, a publicallyavailable probabilistic exposure model. 

The purpose of the February 2011 SAP 

meeting will be to review the PBPK/PD 

model and to evaluate the proposed 

approach for linking this PBPK model to 

the probabilistic exposure model. 

The linking of the chlorpyrifos PBPK/ 

PD model with a probabilistic exposure 

model may provide opportunities to 

calculate distributions of exposure to 

chlorpyrifos and its metabolites with 

cholinesterase inhibition levels across 

the U.S. population. In addition, this 


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approach may allow estimation of dataderived uncertainty factors that consider 

use of toxicokinetic and toxicodynamic 

data to inform quantitative 

extrapolations for interspecies 

differences and human variability in 

dose response assessment. The topics to 

be covered in the February 2011 SAP 

are consistent with EPA’s Office of 

Pesticide Programs continuing efforts to 

improve the scientific basis for risk 

assessment by broadening the 

application of probabilistic exposure 

techniques and PBPK models. The 

Agency has a conceptually similar effort 

on-going to link PBPK models for 

pyrethroids with Stochastic Human 

Exposure and Dose Simulator (SHEDS) 

exposure software, a probabilistic 

exposure model developed by the EPA’s 

Office of Research and Development, 

which was reviewed by the SAP in July 

2010. The current effort by Dow 

AgroSciences is a research effort which 

may, if sufficiently robust, inform future 

risk assessments; the February meeting 

is a key milestone in this research. The 

Agency will solicit feedback from the 

Panel on technical issues related to 

PBPK/PD model, the proposed approach 

for merging the PBPK/PD model with 

CARES, and the use of such merged 

models in risk assessment. 

C. FIFRA SAP Documents and Meeting 

Minutes 

EPA’s background paper, related 

supporting materials, charge/questions 

to FIFRA SAP, FIFRA SAP composition 

(i.e., members and ad hoc members for 

this meeting), and the meeting agenda 

will be available by late January 2011. 

In addition, the Agency may provide 

additional background documents as the 

materials become available. You may 

obtain electronic copies of these 

documents, and certain other related 

documents that might be available 

electronically, at http:// 

www.regulations.gov and the FIFRA 

SAP homepage at http://www.epa.gov/ 

scipoly/sap. 

FIFRA SAP will prepare meeting 

minutes summarizing its 

recommendations to the Agency 

approximately 90 days after the 

meeting. The meeting minutes will be 

posted on the FIFRA SAP Web site or 

may be obtained from the OPP 

Regulatory Public Docket at http:// 

www.regulations.gov. 

List of Subjects 

Environmental protection, Pesticides 

and pests. 

Dated: November 23, 2010. 

Frank Sanders, 

Director, Office of Science Coordination and 

Policy. 

[FR Doc. 2010–30630 Filed 12–7–10; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

[FRL–9236–6; Docket ID No. EPA–HQ–ORD– 

2010–0991] 

Lymphohematopoietic Cancers 

Induced by Chemicals and Other 

Agents: Overview and Implications for 

Risk Assessment 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice of public comment 

period. 

SUMMARY: EPA is announcing a 45-day 

public comment period for the draft 

document titled, 

‘‘Lymphohematopoietic Cancers 

Induced by Chemicals and Other 

Agents: Overview and Implications for 

Risk Assessment’’ (EPA/600/R–10/ 

095A). The draft document was 

prepared by the National Center for 

Environmental Assessment within 

EPA’s Office of Research and 

Development. The draft document 

provides an overview of the types and 

mechanisms underlying the 

lymphohematopoietic cancers induced 

by chemical agents and radiation in 

humans, with a primary emphasis on 

leukemia and leukemia-inducing agents. 

In addition, the document also focuses 

on how mechanistic information on 

human leukemia-inducing agents can 

inform risk assessment. 

EPA is releasing this draft document 

solely for the purpose of predissemination peer review under 

applicable information quality 

guidelines. This draft document has not 

been formally disseminated by EPA. It 

does not represent and should not be 

construed to represent any Agency 

policy or determination. All public 

comments received will be provided to 

the peer reviewers at the beginning of 

the review process. 

DATES: The 45-day public comment 

period begins December 8, 2010, and 

ends January 24, 2011. Technical 

comments should be in writing and 

must be received by EPA by January 24, 

2011. 

ADDRESSES: The draft 

‘‘Lymphohematopoietic Cancers 

Induced by Chemicals and Other 

Agents: Overview and Implications for 

Risk Assessment’’ is available primarily 

via the Internet on the National Center 

for Environmental Assessment’s home 

page under the Recent Additions and 

the Data and Publications menus at 

http://www.epa.gov/ncea. A limited 

number of paper copies are available 

from the Information Management 

Team, NCEA; telephone: 703–347–8561; 

facsimile: 703–347–8691. If you are 

requesting a paper copy, please provide 

your name, your mailing address, and 

the draft document title, 

‘‘Lymphohematopoietic Cancers 

Induced by Chemicals and Other 

Agents: Overview and Implications for 

Risk Assessment.’’ 

Comments may be submitted 

electronically via http:// 

www.regulations.gov, by mail, by 

facsimile, or by hand delivery/courier. 

Please follow the detailed instructions 

provided in the SUPPLEMENTARY

INFORMATION section of this notice. 

FOR FURTHER INFORMATION CONTACT: For 

information on the public comment 

period, contact the Office of 

Environmental Information Docket; 

telephone: 202–566–1752; facsimile: 

202–566–1753; or e-mail: 

ORD.Docket@epa.gov. 

For technical information, contact 

Nagu Keshava, NCEA; telephone: 919– 

541–3047; facsimile: 919–541–0245; or 

e-mail: keshava.nagu@epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. Information About the Project/ 

Document 

This project was initiated to better 

understand the mechanisms underlying 

the lymphohematopoietic cancers 

induced by chemical agents in humans. 

A draft report was developed that 

provides an overview of types and 

mechanisms underlying the 

lymphohematopoietic cancers induced 

by both chemical agents and radiation 

in humans, with a primary emphasis on 

leukemia and leukemia-inducing agents. 

II. How to Submit Technical Comments 

to the Docket at http:// 

www.regulations.gov 

Submit your comments, identified by 

Docket ID No. EPA–HQ–ORD–2010– 

0991, by one of the following methods: 

• http://www.regulations.gov: Follow 

the on-line instructions for submitting 

comments. 

• E-mail: ORD.Docket@epa.gov. 

• Fax: 202–566–1753. 

• Mail: Office of Environmental 

Information (OEI) Docket (Mail Code: 

2822T), U.S. Environmental Protection 

Agency, 1200 Pennsylvania Ave., NW., 

Washington, DC 20460. The phone 

number is 202–566–1752. 

• Hand Delivery: The OEI Docket is 

located in the EPA Headquarters Docket 


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