### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY **WASHINGTON D.C. 20460**

OFFICE OF CHEMICAL SAFETY AND

POLLUTION PREVENTION 

### PC Code: 027412 **DP barcode:** 370764 **Date:** July

20 , 2010
**MEMORANDUM Subjec** t: Tier II Drinking Water Exposure Assessment for Fluopicolide and its Major

Degradate, 2,6

-Dichlorobenzamide (BAM) for Use on Potatoes, Carrots , Sugar Beets and Brassica (Cole) Leafy Vegetables **To** : Tony

Kish, Risk Manager Janet Whitehurst, Risk Manager Reviewer Registration Division (7505P) **From** : Robert A. Miller, Environmental Protection Specialist

Environmental Risk Branch I Environmental Fate and Effects Division (7507P) **Approved** Brian Anderson, Acting Branch Chief **By** Environmental Risk Branch I

Environmental Fate and Effects Division (7507P) **Summary** A Tier II screening

-level drinking water assessment was conducted for the proposed new use of fluopicolide on potatoes, carrots , sugar beets and brassica (cole) vegetables

. Because 2,6

- dichlorobenzamide (BAM) is potentially a major toxic degradation product in aerobic soil metabolism, aquatic photolysis and soil photolysis studies , it was also included in the exposure asses sment for drinking water

.

### Fluopicolide belongs to the benzamide pyridine chemical class. Fluopicolide controls oomycete

pathogens on contact, and is mesosystemic meaning that it translocates toward the stem tips, but not toward the roots. Fluopicolide is formulated as a suspension concentrate, V

- 10161 4 SC, containing 39.5% fluopicolide. It also is formulated as a suspension concentrate premix, V

10162 Premix, containing 5.54% fluopicolide and 55.4% propamocarb hydrochloride. This drinking water assessment only addresses the active ingredient, fluopicolide and its degradate BAM. It does not address the other active ingredient found in V

- 10162 premix, which contains 55. 4% propamocarb hydrochloride. The additive or sy nergistic qualities of fluopicolide and propamocarb hydrochloride are not addressed. Surface water concentrations were estimated using the Tier II model PRZM version 3.12/ EXAMS version 2.98. Ground water concentrations were estimated using the Tier I SCI

-GROW model. This assessment addresses the Estimated Drinking Water Concentrations (EDWCs) of the parent fluopicolide and its major degradate 2,6

-dichlorobenzamide in drinking water

. The recommended estimated drinking water concentrations (EDWCs) for fluopicolide are provided below

. **25.50** μ g/Lfor the 1 in 10 year annual peak concentration (acute) **24.14** μg/Lfor the 1 in 10 year annual mean concentration (non

-cancer chronic) and **22.36** μ g/Lfor the 30 ye ar annual mean concentration (cancer chronic) Based on PRZM/EXAMS modeling results, the recommended EDWCs for BAM are **4.13** μg /L for the 1 in 10 year annual peak concentration (acute) **3.43** μg /L for the 1 in 10 year annual mean concentration (non

-cancer chronic) and **2.10** μg /L for the 30 year annual mean concentration (cancer chronic) The SCI

- GROW model estimated acute and chronic ground water drinking water concentrations for fluopicolide and BAM are not expected to exceed 0.5 μg/L and 2.96 μg/L respectively. **Monitoring Dat a**  Fluopicolide and BAM are not included as analytes monitored in U.S. surface and groundwater under the USGS’s National Water Quality Assessment (NAWQA) program

. Samples from European water supply wells detected the maj or degradate BAM. BAM in European groundwater, however, originated from use of dichlobenil. BAM is the main pesticide residue in Danish groundwater, with 19.7% of the abstraction wells analyzed in 2003 having detectable BAM concentrations and 8.1% of the wells containing BAM concentrations exceeding the EC threshold limit (0.1 μ g liter−1 

### ) ( Sorensen, et al. 2007)

. **Surface Water Assessment** The proposed new uses of fluopicolide are for application to potatoes, sugar beets , carrots and brassica vegetables

. The exposure concentrations for drinking water exposure assessments were

### estimated based on EFED’s aq uatic Tier II model PRZM/EXAMS. A graphical user interface (pe5v01.pl), (http://www.epa.gov/oppefed1/models/water/pe4_instructions_public.htm) developed by the EPA, was used to facilitate inputting chemical and use specific parameters into the appropriate PRZM input files and EXAMS chemical files. This approach employs PRZM , which simulates runoff and erosion from an agricultural field on a daily time step. The runoff and erosion flux output data from PRZM are used as chemical loadings to EXAMS, which simulates surface water in order to predict the Estimated Drinking Water Concentrations (EDWCs). EDWCs for drinking water exposure assessment were determined using an Index Reservoir (IR) scenario which describes a generic scenario for the EXAMS component of the modeling exercise. Chemical Application Methods (CAMs) 2 and 1 were used in PRZM/EXAMS modeling to calculate surface water ECCs for fluopicolide and BAM, respectively. CAM 2 was employed to model the foliar application of fluopicolide

. CAM 1 was used to simulate the dissipation and degradation of BAM on the soil after f oliar application of the parent through linearly decreasing distribution in the soil to a depth of 4 cm. Potatoes, carrots , brassica vegetables and sugar beets are proposed to be added to the currently approved root and tuber sub groups on the V

- 10161 4 SC and fluopicolide technical labels

. Potatoes are proposed to be added to the V

- 10162 Premix label. The proposed aerial and ground spray application rates for potatoes, carrots and , brassica vegetables on the V

- 10161 4 SC and fluopicolide technical labels are 3 applications of 0.1 25 lbs ai/A at 7 day intervals. The proposed aerial and ground spray

application rates on the V

- 10162 Premix label for potatoes are 4 applications of 0.09 lbs ai/A at 10 day intervals. Proposed new target crops, application dates, modeled crop scenarios, maximum application rates and minimum application intervals are displayed in **Table 1**

. **Table 1. Target Crops, Crop**  **Scenario, Initial Application Date, Application**  **Rates and Minimum Application Interval for Proposed**  **Fluopicolid e**  **Uses Crop**  **Crop Scenario /** 

**Application Date (day** **- month)**  **Maximum**

**Application Rate**  **(lbs a.i./acre) Maximum** 

**Number of Applications**  **Minimum**

**Interval (days)**  **Fluopicolide Technical and V -**  **10161 4 SC Label s**  Brassica Vegetables CA Lettuce 0. 125 3 7

FL Cabbage Carrots FL Carrots (15

- 11) 0. 125 3 7 Potatoes ID Potatoes (01

-08) 0.125 3 7

ME Potatoes (01

-08) Sugar beets MN Sug. Beet (01

-07) 0.125 3 7 

### V**- 10162 Premix Label**  Potatoes ID Potatoes (01

-08) 0.09 4 10

ME Potatoes (01

-08) 

### PRZM/EXAMS Modeling of Fluopicolide

### The appropriate PRZM and EXAMS input parameters for fluopicolide are selected from

reviewed environmental fate data submitted by the registrant (**Table 2**)

. PRZM/EXAMS input parameters used in this assessment are in accordance with EFED water model PRZM/EXAMS input parameter guidance (U.S. EPA 2009). The input parameters employed are similar to those used in the 2007 fluopicolide drinking water assessment for the parent (March 7, 2007, DP barcode 325804)

.
**Table 2 . PRZM/EXAMS Input Par** **ameters for Proposed**  **Fluopicolide Uses Parameter**  **Input Value and Unit Comment**  **Source** Method of application Aerial and ground Label CAM 2, foliar applied Hydrolysis (t 1/2) 0 Stable MRID 46708420 Spray drift and application efficiency Aerial: 0.16 Ground: 0. 0 64 Efficiency

– aerial: 0.95, Ground 0.99 Guidance Aerobic soil metabolism (t 1/2) 454.5 days Upper 90th percentile of acceptable aerobic soil half

-lives (390, 392, 457 days) MRID 46708427 MRID 46708428
Aerobic aquatic metabolism (t 1/2) 146.4 days Upper 90th percentile of half

-lives (135, 124 days) MRID 46708429 Anaerobic aquatic metabolism (t 1/2) 2162 days Upper 90th percentile of half

-lives (1553, 967 days) MRID 46708429 Aquatic photolysis (t 1/2) 170 days MRID 46708422 Vapor pressure 2.2 8×10 - 9 Torr Product Chemistry Solubility in water (pH 7, 20 °C) 3.02 ppm Henry’s Law constant (20 °C) 4.11×10 - 10 atm/mol.m3 Molecular weight 383.59 Partition coefficient Koc 3 40 mL/g Average Koc (373, 356, 349, 341 and 283) 

### PRZM/EXAMS Modeling of BAM BAM was modeled in PRZM/EXAMS because it is of concern to HED due its potential toxicity to mammals

. BAM is a major degradate of both fluopicolide and dichlobenil

. Because guideline fate studies for BAM were not available, literature data from (027412 DP D325803+) were used in surface and groundwater modeling. The application rate of BAM was determined based on the maximum detected amount of 40.2% in the aerobic soil metabolism study of fluopicolide (MRID 46708428 ) and then multiplied by the percentage difference in molecular weight (MW) between BAM (190.3) and fluopicolide (383.59)

. The corresponding maximum application rates and application intervals of BAM for the target crops are shown in **Table 3**

. **Table 3 . Target Crops,**  **Crop Scenario, Application Rates and Minimum**  **Application Interval for BAM**

### Crop **Crop Scenario/ Application Date**  **(day -** **month) Max.** 

**Application Rate**  **(lbs a.i./acre) Maximum** 

**Number of Applications**  **Minimum**

**Interval (days)**  **Fluopicolide Technical and V -**  **10161 4 SC Labels** Brassica Vegetables CA Lettuce 0.025 3 7

FL Cabbage Carrots FL Carrots (15

- 11) 0.025 3 7 Potatoes ID Potatoes (01

-08) 0.025 3 7

ME Potatoes (01

-08) Sugar beets MN Sug. Beet (01

-07) 0.025 3 7 

### V**- 10162 Premix Label**  Potatoes ID Potatoes (01

-08) 0 .02 2 4 10

ME Potatoes (01

-08) 1 = V

- 10161 4 SC label

- 0.125 ai lb/A (application rate) x 0.402 (Maximum detected in fate study) x (190.3/383.59 [Molecular Weight Ratio] ) 2 v_10162 Premix label

- 0.1 ai lb./A (application rate) x 0.402 (Maximum detected in fate study) x (190.3/383.59 [Molecular Weight Ratio] ) 

### The input parameters used for BAM (**Table 4**) are similar to those used in the 2007 fluopicolide drinking water assessment for the major degradate (May 3, 2007, DP Barcode: 325804) BAM was the major transformation product in the aerobic soil metabolism study (MRID 46708428 ) detected at a maximum 40.2% of the applied at the end of the 369 day study

. Since the maximum amount of BAM is detected at the end of experiment (369 days) and the potential for continuing formation of BAM can not be discounted; therefore, it is assumed that BAM is stable in the aerobic soil environment. **Table 4 . PRZM/EXAMS Input Parameters for**  **BAM Parameter**  **Input Value and Unit Comment**  **Source** Method of application Ground CAM 1 BAM is a metabolite, so assume directly applied to soil Hydrolysis (t 1/2) 0 Stable HSDB, 2002 Spray drift and application efficiency 0 drift (assume soil applications) Efficiency

– 1.0 Aerobic soil metabolism (t 1/2) Stable Assumed stable MRID 46708428 Aerobic aquatic metabolism (t 1/2) Stable Assumed stable PRZM/EXAM Guidence (2 x aerobic soil metabolism t 1/2) Anaerobic aquatic metabolism (t 1/2) 0 Assume stable Aquatic photolysis (t 1/2) 0 Assume stable Partition coefficient Koc 3 0 mL/g HSDB, 2002

### Table 4 **. PRZM/EXAMS Input Parameters for BAM** 

**Parameter Input Value and Unit**  **Comment Source**  Plant Decay Rate PLDKRT 1.98×10 -2 (days - 1 ) Foliar pesticide decay rate constant assuming default half

-life of 35 days Vapor pressure 3.26 ×10 - 9 mmHg Product Chemistry Solubility in water (pH 7, 20 °C) 2700 ppm Henry’s Law constant (20 °C) 1.22×10 - 9 atm/mol.m3 Molecular weight 190.03 

### Surface Water Modeling Results Since fluopicolide can be used on various crops, the final drinking water estimates were adjusted with a default value of 0.87 as Percent Cropped Area (PCA) factor. The estimated drinking water concentration (EDWC) values are summarized in **Table 5** 

. EDWCs generated by the scenarios are expected to be generally representative of concentrations that would result from field application of fluopicolide on potato, sugar beet and carrot crops

. Example PRZM/EXAMS output files for the crop scenarios are provided in the **Appendix A**

. **Table 5 .**  **PRZM /EXAMS**  **Estimated Drinking Water Concentrations, EDWCs (μg/L) for**  **Fluopicolide and BAM on**  **Potato es** **, Sugar B eet** **s ,**  **Carrot s**  **and Brassica Vegetables**  **after Adjustment for D efault PCA of 0.87**  **Crop Scenario/ Application Method**  **Annual Peak (acute)**  **Annual Mean**

**(non -** **cancer chronic)**  **30 Year Annual Mean**  **(cancer chronic) Fluopico** 

**- lide**  ***** **BAM  ** Fluopico**

**- lide** * **BAM  ** Fluop****ico******

**lide*** **BAM  ** Fluopicolide Technical and V****- 10161 4 SC Labels**  **CA Lettuce** Aerial Spray 17.08 16.61 16.13 Ground Spray 15.62 15.20 14.59 Ground Application 1 2. 34 2. 28 2. 23 **FL Cabbage** Aerial Spray 14.8 8 14.15 11.16 Ground Spray 13.85 13. 16 10.21 Ground Application 1 1. 65 1. 48 0.91 **ME Potato**  Aerial Spray 22.80

-- 22.65

-- 22.36

-- Ground Spray 22.17

-- 21.82

-- 21.12

-- Ground Application 1

-- 1. 51

-- 1.44

-- 1.3 7 **ID Potato**

### Ground Water Assessment

For fluopicolide, the SCI

-GROW estimated ground water drinking water concentrations are not expected to exceed 0.5 μg/L, which was based on 3 applications of 0.12 5 lb ai/ac per application. For BAM, the SCI

-GROW estimated ground water drinking water concentrations are not expected to exceed 2. 47 μg/L, which was based on 3 applications of 0.25 lb ai/ac per application. The SCI

- GROW outputs are presented in **Appendi x B** 

. **Data Gaps and Uncertainty** Aerial Spray 12.46

-- 12.23

-- 11.75

-- Ground Spray 10 .40

-- 10.22

-- 9.81

-- Ground Application 1

-- 1.60

-- 1.57

-- 1.51 **MN Sugar Beets** Aerial Spray 15.02

-- 14.36

-- 13.44

-- Ground Spray 14.64

-- 14.12

-- 13.81

-- Ground Application 1

-- 2.44

-- 2.38

-- 2.28 **Florida Carrots** Aerial Spray 25. 50

-- 24. 1 4

-- 2 0

. 79

-- Ground Spray 25. 00

-- 2 3.66

-- 20.43

-- Ground Application 1

-- 4.13

-- 3.43

-- 2.10 

### V**- 10162 Premix Label**  **Potatoes ME** **Potato** Aerial Spray 16.00

-- 15.81

-- 15.52

-- Ground Spray 14.91

-- 14.75

-- 14.46

-- Ground Application 1

-- 1.57

-- 156

-- 1.55 **ID Potato** Aerial Spray 11.55

-- 11.34

-- 10.91

-- Ground Spray 9.62

-- 9.43

-- 9.06

-- Ground Application 1

-- 1.51

-- 1.49

-- 1.42 * CAM 2 used in PRZM/EXAMS

. ** CAM 1 used in PRZM/EXAMS

. 1 Since fluopicolide degrades to BAM after foliar application, CAM 2 is used to represent ground application.

###  This drinking water assessment only addresses the active ingredient, fluopicolide in the V

- 10162 Premix formulation . It does not address the other active ingredient found in V

10162 premix, which contains 55.4% propamocarb hydrochloride. The additive or sy nergistic qualities of fluopicolide and propamocarb hydrochloride are not addressed.

 Due to the lack of environmental fate data for 2,6

- dichlorobenzamide (BAM) EFED assumed that BAM is stable to the aqueous photolysis, aerobic aquatic metabolism, anaerobic aquatic metabolism and aerobic soil metabolism in PRZM/EXAMS modeling. In SCIGROW modeling aerobic soil metabolism is assumed to be stable.

 The Koc 

### of 30 was referenced in a Danish report (Cohr, 2002) , which indicates a “mobile” class (FAO classification scheme). However, based on the chemical structure of BAM, PCKOCWI

N of the EPI Suite(http://www.epa.gov/opptintr/exposure/pubs/episuite htm) predicts a Koc 

### of 141, which indicates a “moderately mobile” class. The lower value of 30 was used in this risk assessment to provide more conservative estimates. **References** Karl

-Heinz Cohr and Flemming A. Simonsen. 2004. Evaluation of Health Hazards by Exposure to BAM (2,6

-Dichlorobenzamide) and Risk Characterisation of Drinking Water Exposure. Danish Toxicology Centre. Environmental Project Nr. 943 2004 Brusch, W. 2004. Pesticider og nedbrydningsprodukter, p. 33

-40. In L. F. Jorgensen (ed.), Groundwater monitoring 2003. Geological Survey of Denmark and Greenland, Copenhagen, D enmark. HSDB, 2002 [Hazardous Substances Data Bank]. National Library of Medicine. Last update: 6

- 8

-2002. Access date: 05

-25

-20 10 . http://toxnet.nlm.nih.gov/cgibin/sis/htmlgen?HSDB.

### Appendix A

**– Example PRZM/EXAMS (PE5** **) Output Files**

**Fluopicolide , Label** **- 10161 4 SC**  Florida Carrots

– Aerial Spray
stored as FlFLCa.out Chemical: Fluopicolide PRZM environment: FLcarrotSTD.txt modified Tueday, 29 May 2007 at 13:45:36 EXAMS environment: ir298.exv modified Tueday, 26 August 2008 at 06:14:08 Metfile: w12844.dvf modified Tueday, 26 August 2008 at 06:14:22 Water segment concentrations (ppb) Year Peak 96 hr 21 Day 60 Day 90 Day Yearly 1961 2.522 2.487 2.363 1.53 1.02 0.2515 1962 4.995 4.951 4.511 4.16 3.888 2.792 1963 14.12 9.13 1 6.484 4.767 4.68 3.713 1964 21.97 21.71 20.82 15.1 12.79 9.813 1965 19.12 18.95 18.27 17.02 16.14 10.38 1966 15.79 15.65 15.43 14.74 14.22 9.399 1967 9.338 9.268 8.955 8.545 8.377 6.056 1968 6.936 6.889 6.682 6.298 5.984 4.513 1969 11.42 11.31 10.91 10.4 10.36 7.591 1970 15.1 14.97 14.57 13.98 13.43 8.849 1971 7.353 7.276 6.96 6.361 5.974 5.063 1972 6.629 6.563 6.302 6.043 5.868 4.093 1973 5.497 5.447 5.309 5.204 5.071 3.589 1974 11.78 11.63 11.23 10.28 9.668 6.569 1975 9.776 9.676 9.278 8.502 8.014 5.36 1976 10.48 10.37 10.11 9.279 8.706 5.925 1977 18.18 17.98 17.53 12.09 9.12 6.765 1978 16.8 16.65 16.09 15.06 14.32 9.448 1979 13.22 13.15 12.75 11.9 11.32 7.796 1980 13.11 12.99 12.57 12.07 11.49 8.113 1981 12.09 9.235 8.938 8.487 8.423 5.939 1982 12.57 12 .44 11.99 11.29 11.2 7.926 1983 13.24 13.12 12.79 11.89 11.43 7.777 1984 46.96 46.39 44.45 29.38 20.82 10.49 1985 37.53 37.2 35.9 33.24 31.74 21.161986 29.55 29.2 27.94 22.4 21.39 15.35

1987 27.23 26.99 26.03 24.07 22.74 14.59 1988 11.15 11.08 10.84 10.45 10.14 6.907 1989 7.344 7.278 5.566 5.186 5.127 4.135 1990 7.053 6.976 6.767 6.313 6.233 4.321 Sorted results Prob. Peak 96 hr 21 Day 60 Day 90 Day Yearly 0.032258064516129 46.96 46.39 44.45 33.24 31.74 21.16 0.0645161290322581 37.53 37.2 35.9 29.38 22.74 15.35 0.0967741935483871 29.55 29.2 27.94 24.07 21.39 14.59 0.129032258064516 27.23 26.99 26.03 22.4 20.82 10.49 0.161290322580645 21.97 21.71 20.82 17.02 16.14 10.38 0.193548387096774 19.12 18.95 18.27 15.1 14.32 9.813 0.225806451612903 18.18 17.98 17.53 15.06 14.22 9.448 0.258064516129032 16.8 16.65 16.09 14.74 13.43 9.399 0.290322580645161 15.79 15.65 15.43 13.98 12.79 8.849 0.32258064516129 15.1 14.97 14.57 12.09 11.49 8.113 0.354838709677419 14.12 13.15 12.79 12.07 11.43 7.926 0.387096774193548 13.24 13.12 12.75 11.9 11.32 7.796 0.419354838709677 13.22 12.99 12.57 11.89 11.2 7.777 0.451612903225806 13.11 12.44 11.99 11.29 10.36 7.591 0.483870967741936 12.57 11.63 11.23 10.45 10.14 6.907 0.516129032258065 12.09 11.31 10.91 10.4 9.668 6.765 0.54838709677 4194 11.78 11.08 10.84 10.28 9.12 6.569 0.580645161290323 11.42 10.37 10.11 9.279 8.706 6.056 0.612903225806452 11.15 9.676 9.278 8.545 8.423 5.939 0.645161290322581 10.48 9.268 8.955 8.502 8.377 5.925 0.67741935483871 9.776 9.235 8.938 8.487 8.014 5.36 0. 709677419354839 9.338 9.131 6.96 6.361 6.233 5.063 0.741935483870968 7.353 7.278 6.767 6.313 5.984 4.513 0.774193548387097 7.344 7.276 6.682 6.298 5.974 4.321 0.806451612903226 7.053 6.976 6.484 6.043 5.868 4.135 0.838709677419355 6.936 6.889 6.302 5.204 5 .127 4.093 0.870967741935484 6.629 6.563 5.566 5.186 5.071 3.713 0.903225806451613 5.497 5.447 5.309 4.767 4.68 3.589 0.935483870967742 4.995 4.951 4.511 4.16 3.888 2.792 0.967741935483871 2.522 2.487 2.363 1.53 1.02 0.2515 0.1 29.318 28.979 27.749 23.903 21.333 14.18 Average of yearly averages: 7.48911666666667 Inputs generated by pe5.pl
- Novemeber 2006 Data used for this run: Output File: FlFLCa Metfile: w12844.dvf PRZM scenario: FLcarrotSTD.txt EXAMS environment file: ir298.exv Chemical Name: Fl uopicolide Description Variable Name Value Units Comments Molecular weight mwt 383.59 g/mol Henry's Law Const. henry 4.11e
- 10 atm
- m^3/mol Vapor Pressure vapr 2.28e
- 9 torr Solubility sol 3.02 mg/L Kd Kd mg/L Koc Koc 340 mg/LPhotolysis half
- life kdp 170 da ys Half
- life

Aerobic Aquatic Metabolism kbacw 146.4 days Halfife Anaerobic Aquatic Metabolism kbacs 2162 days Halfife Aerobic Soil Metabolism asm 454.5 days Halfife Hydrolysis: pH 7 0 days Half
- life Method: CAM 2 integer See PRZM manual Incorporation Depth : DEPI 0 cm Application Rate: TAPP 0.14 kg/ha Application Efficiency: APPEFF 0.95 fraction Spray Drift DRFT 0.16 fraction of application rate applied to pond Application Date Date 15
- 11 dd/mm or dd/mmm or dd

- mm or dd
- mmm Interval 1 interval 7 days Set to 0 or delete line for single app. app. rate 1 apprate 0.14 kg/ha Interval 2 interval 7 days Set to 0 or delete line for single app. app. rate 2 apprate 0.14 kg/ha Record 17: FILTRA IPSCND 2 UPTKF Record 18: PLVKRT PLDKRT 0.0198 FEXTRC 0.5 Flag for Ind ex Res. Run IR Reservoir Flag for runoff calc. RUNOFF total none, monthly or total(average of entire run) 

### Fluopicolide, V**- 10162 Premix Label**  ME Potatoes

– Ground Spray stored as FlMEPoG.out Chemical: Fluopicolide PRZM environment: MEpotatoSTD.txt modif ied Tueday, 29 May 2007 at 13:56:18 EXAMS environment: ir298.exv modified Tueday, 26 August 2008 at 06:14:08 Metfile: w14607.dvf modified Tueday, 26 August 2008 at 06:14:52 Water segment concentrations (ppb) Year Peak 96 hr 21 Day 60 Day 90 Day Yearly 196 1 6.049 6.006 5.833 5.442 5.212 3.546 1962 6.838 6.818 6.784 6.613 6.439 5.594 1963 12.55 12.49 12.27 11.72 11.26 8.609 1964 13.8 13.76 13.56 13.22 12.84 10.72 1965 10.81 10.78 10.68 10.41 10.3 9.184 1966 10.03 9.999 9.882 9.719 9.583 8.212 1967 10.76 10.7 3 10.63 10.54 10.34 8.638 1968 18.51 18.43 18.27 17.76 17.29 13.81 1969 17.25 17.2 17.03 16.52 16.03 13.41 1970 16.73 16.68 16.55 16.2 15.87 13.52 1971 18.44 18.37 18.11 17.42 16.87 13.84 1972 16.88 16.81 16.67 16.32 16.05 13.66 1973 20.33 20.26 20.08 19.7 19.38 15.79 1974 20.11 20.04 19.93 19.44 18.98 15.77 1975 19.05 18.99 18.72 18.15 17.62 14.85 1976 23.8 23.7 23.36 22.73 22.08 17.59 1977 24.15 24.07 23.79 23.31 22.76 18.64 1978 23.22 23.16 22.77 21.98 21.34 18.581979 24.17 24.09 23.9 23.43 23.03 18.79

1980 19.37 19.31 19.2 18.72 18.28 15.73 1981 23.47 23.39 23.15 22.67 22.54 18.6 1982 23.36 23.29 22.92 22.05 21.31 17.83 1983 23.32 23.25 23.12 22.97 22.69 19.1 1984 22.73 22.66 22.44 21.8 21.27 17.94 1985 20.9 20.84 20.61 19.98 19.37 16.47 1986 26.55 26.4 6 26.12 25.31 24.66 20.9 1987 25.48 25.41 25.07 24.29 23.67 19.63 1988 25.48 25.42 25.08 24.23 23.56 19.53 1989 25.54 25.45 25.09 24.64 23.95 19.61 1990 22.54 22.48 22.31 21.88 21.44 18.46 Sorted results Prob. Peak 96 hr 21 Day 60 Day 90 Day Yearly 0.0322 58064516129 26.55 26.46 26.12 25.31 24.66 20.9 0.0645161290322581 25.54 25.45 25.09 24.64 23.95 19.63 0.0967741935483871 25.48 25.42 25.08 24.29 23.67 19.61 0.129032258064516 25.48 25.41 25.07 24.23 23.56 19.53 0.161290322580645 24.17 24.09 23.9 23.43 23.0 3 19.1 0.193548387096774 24.15 24.07 23.79 23.31 22.76 18.79 0.225806451612903 23.8 23.7 23.36 22.97 22.69 18.64 0.258064516129032 23.47 23.39 23.15 22.73 22.54 18.6 0.290322580645161 23.36 23.29 23.12 22.67 22.08 18.58 0.32258064516129 23.32 23.25 22.92 2 2.05 21.44 18.46 0.354838709677419 23.22 23.16 22.77 21.98 21.34 17.94 0.387096774193548 22.73 22.66 22.44 21.88 21.31 17.83 0.419354838709677 22.54 22.48 22.31 21.8 21.27 17.59 0.451612903225806 20.9 20.84 20.61 19.98 19.38 16.47 0.483870967741936 20.33 2 0.26 20.08 19.7 19.37 15.79 0.516129032258065 20.11 20.04 19.93 19.44 18.98 15.77 0.548387096774194 19.37 19.31 19.2 18.72 18.28 15.73 0.580645161290323 19.05 18.99 18.72 18.15 17.62 14.85 0.612903225806452 18.51 18.43 18.27 17.76 17.29 13.84 0.64516129032 2581 18.44 18.37 18.11 17.42 16.87 13.81 0.67741935483871 17.25 17.2 17.03 16.52 16.05 13.66 0.709677419354839 16.88 16.81 16.67 16.32 16.03 13.52 0.741935483870968 16.73 16.68 16.55 16.2 15.87 13.41 0.774193548387097 13.8 13.76 13.56 13.22 12.84 10.72 0.8 06451612903226 12.55 12.49 12.27 11.72 11.26 9.184 0.838709677419355 10.81 10.78 10.68 10.54 10.34 8.638 0.870967741935484 10.76 10.73 10.63 10.41 10.3 8.609 0.903225806451613 10.03 9.999 9.882 9.719 9.583 8.212 0.935483870967742 6.838 6.818 6.784 6.613 6. 439 5.594 0.967741935483871 6.049 6.006 5.833 5.442 5.212 3.546 0.1 25.48 25.419 25.079 24.284 23.659 19.602 Average of yearly averages: 14.8851 Inputs generated by pe5.pl
- Novemeber 2006 Data used for this run: Output File: FlMEPoG Metfile: w1460 7.dvf PRZM scenario: MEpotatoSTD.txt EXAMS environment file: ir298.exv Chemical Name: FluopicolideDescription Variable Name Value Units Comments

Molecular weight mwt 383.59 g/mol Henry's Law Const. henry 4.11e
- 10 atm
- m^3/mol Vapor Pressure vapr 2.28e
- 9 to rr Solubility sol 3.02 mg/L Kd Kd mg/L Koc Koc 340 mg/L Photolysis half
- life kdp 170 days Half
- life Aerobic Aquatic Metabolism kbacw 146.4 days Halfife Anaerobic Aquatic Metabolism kbacs 2162 days Halfife Aerobic Soil Metabolism asm 454.5 days Halfife Hyd rolysis: pH 7 0 days Half
- life Method: CAM 2 integer See PRZM manual Incorporation Depth: DEPI 0 cm Application Rate: TAPP 0.14 kg/ha Application Efficiency: APPEFF 0.99 fraction Spray Drift DRFT 0.064 fraction of application rate applied to pond Applicati on Date Date 08
- 01 dd/mm or dd/mmm or dd

- mm or dd
- mmm Interval 1 interval 7 days Set to 0 or delete line for single app. app. rate 1 apprate 0.14 kg/ha Interval 2 interval 7 days Set to 0 or delete line for single app. app. rate 2 apprate 0.14 kg/ha Record 17: FILTRA IPSCND 2 UPTKF Record 18: PLVKRT PLDKRT 0.0198 FEXTRC 0.5 Flag for Index Res. Run IR Reservoir Flag for runoff calc. RUNOFF total none, monthly or total(average of entire run) 

### BAM, V**- 10161 4 SC**  FL Carrots

– Ground Application stored as BAMFLCa.out Chemical: BAM PRZM environment: FLcarrotSTD.txt modified Tueday, 29 May 2007 at 13:45:36 EXAMS environment: ir298.exv modified Tueday, 26 August 2008 at 06:14:08 Metfile: w12844.dvf modified Tueday, 26 August 2008 at 06:14:22 Water segment c oncentrations (ppb) Year Peak 96 hr 21 Day 60 Day 90 Day Yearly 1961 0.0961 0.09258 0.07941 0.03853 0.02569 0.006334 1962 0.7555 0.7278 0.2673 0.09372 0.06261 0.0236 1963 1.134 1.092 0.7143 0.3918 0.3162 0.1382 1964 5.083 4.927 4.339 2.51 1.676 0.5524 196 5 2.605 2.511 2.157 1.574 1.271 0.4151 1966 0.6324 0.6094 0.5438 0.3998 0.323 0.1346 1967 0.2018 0.1944 0.1668 0.1162 0.0944 0.04614 1968 0.4884 0.4705 0.4036 0.2005 0.1339 0.04606 1969 1.394 1.348 1.231 0.6628 0.4433 0.198 1970 0.8653 0.834 0.7179 0.5249 0.424 0.131 1971 0.05101 0.04914 0.03785 0.02546 0.02059 0.010431972 0.04626 0.04457 0.03565 0.02599 0.02098 0.009201

1973 0.2198 0.2117 0.1816 0.1148 0.07662 0.02463 1974 0.7942 0.7736 0.637 0.3866 0.258 0.08173 1975 0.5778 0.5567 0.4781 0.3484 0.2812 0. 1005 1976 0.3578 0.3474 0.3007 0.129 0.0864 0.04617 1977 1.553 1.503 1.362 0.836 0.5579 0.1704 1978 0.8388 0.8084 0.6946 0.5067 0.4093 0.1593 1979 0.5498 0.5297 0.4545 0.2824 0.2279 0.1027 1980 0.6431 0.6242 0.537 0.3478 0.2327 0.1099 1981 0.4563 0.33 0.28 36 0.207 0.1673 0.0543 1982 1.219 1.174 1.007 0.6266 0.4187 0.1694 1983 0.5156 0.4975 0.4284 0.3129 0.2529 0.09122 1984 10.36 10.09 8.708 4.952 3.301 0.8324 1985 4.992 4.811 4.134 3.016 2.437 0.7553 1986 1.867 1.799 1.661 1.036 0.6912 0.1791 1987 1.148 1.1 07 0.9507 0.6933 0.5599 0.2414 1988 0.4663 0.4506 0.3879 0.2831 0.2288 0.07198 1989 0.1437 0.1384 0.06286 0.02493 0.02015 0.00986 1990 0.1213 0.1169 0.1005 0.07317 0.059 0.02066 Sorted results Prob. Peak 96 hr 21 Day 60 Day 90 Day Yearly 0.032258064516129 10.36 10.09 8.708 4.952 3.301 0.8324 0.0645161290322581 5.083 4.927 4.339 3.016 2.437 0.7553 0.0967741935483871 4.992 4.811 4.134 2.51 1.676 0.5524 0.129032258064516 2.605 2.511 2.157 1.574 1.271 0.4151 0.161290322580645 1.867 1.799 1.661 1.036 0.6912 0.2 414 0.193548387096774 1.553 1.503 1.362 0.836 0.5599 0.198 0.225806451612903 1.394 1.348 1.231 0.6933 0.5579 0.1791 0.258064516129032 1.219 1.174 1.007 0.6628 0.4433 0.1704 0.290322580645161 1.148 1.107 0.9507 0.6266 0.424 0.1694 0.32258064516129 1.134 1.0 92 0.7179 0.5249 0.4187 0.1593 0.354838709677419 0.8653 0.834 0.7143 0.5067 0.4093 0.1382 0.387096774193548 0.8388 0.8084 0.6946 0.3998 0.323 0.1346 0.419354838709677 0.7942 0.7736 0.637 0.3918 0.3162 0.131 0.451612903225806 0.7555 0.7278 0.5438 0.3866 0.2 812 0.1099 0.483870967741936 0.6431 0.6242 0.537 0.3484 0.258 0.1027 0.516129032258065 0.6324 0.6094 0.4781 0.3478 0.2529 0.1005 0.548387096774194 0.5778 0.5567 0.4545 0.3129 0.2327 0.09122 0.580645161290323 0.5498 0.5297 0.4284 0.2831 0.2288 0.08173 0.612 903225806452 0.5156 0.4975 0.4036 0.2824 0.2279 0.07198 0.645161290322581 0.4884 0.4705 0.3879 0.207 0.1673 0.0543 0.67741935483871 0.4663 0.4506 0.3007 0.2005 0.1339 0.04617 0.709677419354839 0.4563 0.3474 0.2836 0.129 0.0944 0.04614 0.741935483870968 0.3 578 0.33 0.2673 0.1162 0.0864 0.046060.774193548387097 0.2198 0.2117 0.1816 0.1148 0.07662 0.02463 0.806451612903226 0.2018 0.1944 0.1668 0.09372 0.06261 0.0236 0.838709677419355 0.1437 0.1384 0.1005 0.07317 0.059 0.02066 0.870967741935484 0.1213 0.1169 0 .07941 0.03853 0.02569 0.01043 0.903225806451613 0.0961 0.09258 0.06286 0.02599 0.02098 0.00986 0.935483870967742 0.05101 0.04914 0.03785 0.02546 0.02059 0.009201 0.967741935483871 0.04626 0.04457 0.03565 0.02493 0.02015 0.006334 0.1 4.7533 4.581 3.9363 2 .4164 1.6355 0.53867 Average of yearly averages: 0.1644005 Inputs generated by pe5.pl
- Novemeber 2006 Data used for this run: Output File: BAMFLCa Metfile: w12844.dvf PRZM scenario: FLcarrotSTD.txt EXAMS environment file: ir298.exv Chemical Name: BAM Description Variable Name Value Units Comments Molecular weight mwt 190.03 g/mol Henry's Law Const. henry 1.22e
- 9 atm
- m^3/mol Vapor Pressure vapr 3.26e
- 5 torr Solubility sol 2700 mg/L Kd Kd mg/L Koc Koc 30 mg/L Photolysis half
- life kdp 0 days Half
- life Aerobic Aquatic Metabolism kbacw 0 days Halfife Anaerobic Aquatic Metabolism kbacs 0 days Halfife Aerobic Soil Metabolism asm 0 days Halfife Hydrolysis: pH 7 0 days Half
- life Method: CAM 1 integer See PRZM manual Incorporation Depth: DEPI 4 cm Application Rate: TAPP 0.028 kg/ha Application Efficiency: APPEFF 1 fraction Spray Drift DRFT 0 fraction of application rate applied to pond Application Date Date 15
- 11 dd/mm or dd/mmm or dd

- mm or dd
- mmm Interval 1 interval 7 days Set to 0 or delete line for single a pp. app. rate 1 apprate 0.028 kg/ha Interval 2 interval 7 days Set to 0 or delete line for single app. app. rate 2 apprate 0.028 kg/ha Record 17: FILTRA IPSCND 2 UPTKF Record 18: PLVKRT PLDKRT FEXTRC 0.5 Flag for Index Res. Run IR Reservoir Flag fo r runoff calc. RUNOFF total none, monthly or total(average of entire run)

### BAM, V**- 10162 Premix Label** 

IDPotatoes

– Ground Application stored as MEBAMDW.out Chemical: BAM PRZM environment: MEpotatoSTD.txt modified Tueday, 29 May 2007 at 13:56:18 EXAMS env ironment: ir298.exv modified Tueday, 26 August 2008 at 06:14:08 Metfile: w24156.dvf modified Tueday, 26 August 2008 at 06:15:52 Water segment concentrations (ppb) Year Peak 96 hr 21 Day 60 Day 90 Day Yearly 1961 0.8674 0.8661 0.8614 0.8521 0.8041 0.2243 1 962 0.8692 0.8683 0.8646 0.831 0.8163 0.7957 1963 0.9419 0.941 0.9369 0.9279 0.9213 0.8743 1964 0.839 0.8382 0.8353 0.8297 0.8244 0.7814 1965 0.8147 0.8139 0.8106 0.8031 0.7975 0.7512 1966 0.7054 0.7047 0.7028 0.6968 0.6922 0.6515 1967 0.5997 0.5992 0.5969 0.5919 0.588 0.5658 1968 0.8861 0.885 0.8806 0.8711 0.8641 0.6578 1969 0.9168 0.9158 0.9117 0.8882 0.8332 0.7896 1970 0.8913 0.8904 0.8867 0.8824 0.8771 0.8263 1971 0.9517 0.9507 0.9469 0.9389 0.9324 0.7911 1972 1.014 1.013 1.009 0.9987 0.9942 0.9118 1973 1.446 1.444 1.437 1.426 1.421 1.077 1974 1.383 1.381 1.375 1.363 1.353 1.3 1975 1.676 1.674 1.667 1.651 1.539 1.322 1976 2.171 2.168 2.158 2.134 2.117 1.669 1977 2.067 2.065 2.056 2.037 2.022 1.902 1978 1.769 1.767 1.761 1.746 1.734 1.642 1979 1.587 1.586 1.581 1.568 1.559 1.471 1980 1.51 1.508 1.502 1.487 1.459 1.368 1981 1.453 1.452 1.446 1.433 1.423 1.353 1982 1.628 1.626 1.619 1.606 1.596 1.342 1983 1.814 1.812 1.804 1.787 1.775 1.561 1984 1.734 1.732 1.726 1.71 1.698 1.596 1985 1.469 1.467 1.462 1.449 1.44 1.375 1986 1.318 1.318 1.313 1.305 1.3 1.232 1987 1.144 1.143 1.138 1.13 1.122 1.061 1988 1.234 1.233 1.227 1.141 1.064 0.9967 1989 1.216 1.214 1.209 1.198 1.19 1.121 1990 1.053 1.052 1.048 1.039 1.037 0.9842 Sorted results Prob. Peak 96 hr 21 Day 6 0 Day 90 Day Yearly 0.032258064516129 2.171 2.168 2.158 2.134 2.117 1.902 0.0645161290322581 2.067 2.065 2.056 2.037 2.022 1.669 0.0967741935483871 1.814 1.812 1.804 1.787 1.775 1.642 0.129032258064516 1.769 1.767 1.761 1.746 1.734 1.596 0.161290322580645 1.734 1.732 1.726 1.71 1.698 1.561 0.193548387096774 1.676 1.674 1.667 1.651 1.596 1.471 0.225806451612903 1.628 1.626 1.619 1.606 1.559 1.375 0.258064516129032 1.587 1.586 1.581 1.568 1.539 1.368 0.290322580645161 1.51 1.508 1.502 1.487 1.459 1.3530.3225 8064516129 1.469 1.467 1.462 1.449 1.44 1.342

0.354838709677419 1.453 1.452 1.446 1.433 1.423 1.322 0.387096774193548 1.446 1.444 1.437 1.426 1.421 1.3 0.419354838709677 1.383 1.381 1.375 1.363 1.353 1.232 0.451612903225806 1.318 1.318 1.313 1.305 1.3 1.12 1 0.483870967741936 1.234 1.233 1.227 1.198 1.19 1.077 0.516129032258065 1.216 1.214 1.209 1.141 1.122 1.061 0.548387096774194 1.144 1.143 1.138 1.13 1.064 0.9967 0.580645161290323 1.053 1.052 1.048 1.039 1.037 0.9842 0.612903225806452 1.014 1.013 1.009 0. 9987 0.9942 0.9118 0.645161290322581 0.9517 0.9507 0.9469 0.9389 0.9324 0.8743 0.67741935483871 0.9419 0.941 0.9369 0.9279 0.9213 0.8263 0.709677419354839 0.9168 0.9158 0.9117 0.8882 0.8771 0.7957 0.741935483870968 0.8913 0.8904 0.8867 0.8824 0.8641 0.7911 0.774193548387097 0.8861 0.885 0.8806 0.8711 0.8332 0.7896 0.806451612903226 0.8692 0.8683 0.8646 0.8521 0.8244 0.7814 0.838709677419355 0.8674 0.8661 0.8614 0.831 0.8163 0.7512 0.870967741935484 0.839 0.8382 0.8353 0.8297 0.8041 0.6578 0.903225806451613 0.8147 0.8139 0.8106 0.8031 0.7975 0.6515 0.935483870967742 0.7054 0.7047 0.7028 0.6968 0.6922 0.5658 0.967741935483871 0.5997 0.5992 0.5969 0.5919 0.588 0.2243 0.1 1.8095 1.8075 1.7997 1.7829 1.7709 1.6374 Average of yearly averages: 1.09979 Inputs generated by pe5.pl
- Novemeber 2006 Data used for this run: Output File: MEBAMDW Metfile: w24156.dvf PRZM scenario: MEpotatoSTD.txt EXAMS environment file: ir298.exv Chemical Name: BAM Description Variable Name Value Units Comments Molecular weight mwt 190.03 g/mol Henry's Law Const. henry 1.22e
- 9 atm
- m^3/mol Vapor Pressure vapr 3.26e
- 5 torr Solubility sol 2700 mg/L Kd Kd mg/L Koc Koc 30 mg/L Photolysis half
- life kdp 0 days Half
- life Aerobic Aquatic Metabolism kbacw 0 days Halfife Anaerobic Aquatic Meta bolism kbacs 0 days Halfife Aerobic Soil Metabolism asm 0 days Halfife Hydrolysis: pH 7 0 days Half
- life Method: CAM 1 integer See PRZM manualIncorporation Depth: DEPI 4 cm

Application Rate: TAPP 0.02 kg/ha Application Efficiency: APPEFF 1 fraction Spray Drift DRFT 0 fraction of application rate applied to pond Application Date Date 01
- 08 dd/mm or dd/mmm or dd

- mm or dd
- mmm Interval 1 interval 10 days Set to 0 or delete line for single app. app. rate 1 apprate 0.02 kg/ha Interval 2 interval 10 days Set to 0 or delete line for single app. app. rate 2 apprate 0.02 kg/ha Interval 3 interval 10 days Set to 0 or delete line for single app. app. rate 3 apprate 0.02 kg/ha Record 17: FILTRA IPSCND 2 UPTKF Record 18: PLVKRT PLDKRT FEXTRC 0.5 Flag for Index Re s. Run IR Reservoir Flag for runoff calc. RUNOFF total none, monthly or total(average of entire run) 

## Appendix B

**– SCI** **- GROW outputs**  **Fluopicolide applications on carrots, sugar beets , brassica vegetables**  **and potatoes**

SCIGROW VERSION 2.3 ENVIRONMENTAL FATE AND EFFECTS DIVISION OFFICE OF PESTICIDE PROGRAMS U.S. ENVIRONMENTAL PROTECTION AGENCY

SCREENING MODEL FOR AQUATIC PESTICIDE EXPOSURE


### Fl **uopicolide –**  **V -**  **101 62**  **4 SC Label** SciGrow version 2.3 chemical:Fluopicolide time is 5/10/2010 11: 0:47

------------------------------------------------------------------------ Application Number of Total Use Koc Soil Aerobic rat e (lb/acre) applications (lb/acre/yr) (ml/g) metabolism (days)

------------------------------------------------------------------------ 0.125 3.0 0.375 3.40E+02 454.5

--------------------------------------------- --------------------------- groundwater screening cond (ppb) = 5.00E
- 01 ************************************************************************ 

### BAM

**– V** **- 10162**  **Premix Label** SCIGROW VERSION 2.3 ENVIRONMENTAL FATE AND EFFECTS DIVISION OFFICE OF PESTICIDE PROGRAMS U.S. ENVIRONMENTAL PROTECTION AGENCYSCREENING MODEL FOR AQUATIC PESTICIDE EXPOSURE SciGrow version 2.3 chemical:Premix Label
- BAM time is 5/26/2010 12:30:29

------------------------------------------------------------------------ Application Number of Total Use Koc Soil Aerobic rate (lb/acre) applications (lb/acre/yr) (ml/g) metabolism (days)

------------------------------------------------------------------------ 0.025 3.0 0.075 3.00E+01 9999.0 1

------------------------------------------------------------------------ groundwater screen ing cond (ppb) = 2.47E+01 ************************************************************************ 1 9,999 days was inputted into SCIGROW Soil as the soil metabolism half
- life into parameter to represent the stability of BAM in aerobic soils