UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D
.C

. 20460 

### DEC 15 2011

MEMORANDUM OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION

SUBJECT: BEAD Chemical Profile for Registration Review: TFMlLampricide (036201) FROM:

THRU:

TO: Colwell Cook,.Entomologist

# tf11t1-/.- Biological Analysis Branch
...., JihadAlsadek,Economist

# J~**A~ 71~f**  Science Information and Analysis Branch 

### John Faulkner, 

### Economist 

# cfJvrt**~** Economic Analysis Branch Biological and Economic Analysis Division (7503P) Arnet Jones, Chief 

# M.**~~**

# . Biological Analysis

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# ¥ Diann Sims, Chief C

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# :;:::y::~:::~d**AnalY~SiS** Bran::,. ' 

# 0 Economic Analysis Branch V \I \..

## v.~ Biological and Economic Analy i ivision (7503P) Jill Bloom, Chemical Review Manager Risk Management and Implementation Branch 2 Pesticide Re-evaluation Division (7508P)
Product Review Panel date: December 14, 2011 INTRODUCTION The purpose ofthis document is to convey usage information and a broad overview ofthe pest management roles ofpesticides that are beginning to undergo registration review. The anticipated audience consists ofthe team ofEPA staffcurrently evaluating the registration status ofTFMlLampricide, and eventually the general public. This document builds upon the data already provided inthe "Usage and Label Use DataPackages" that are also provided to 1Registration Review teams by BEAD. The document is based on information and data available to BEAD as ofDecember 2011. TFM (3-trifluoromethyl-4-nitrophenol) is a critically important pesticide. Itis a halogenated mononitrobenzamide that is used to kill sea lamprey larvae (EPA 1999). Sea lampreys are native to the Atlantic Ocean. They are an ocean fish that spawn in fresh water. They were found in Lake Ontario in 1835, and introduced into Lake Erie in 1921, probably through the Welland Canal (USDA 2011). These invasive pests are aggressive parasites offish and have reduced the populations ofnative fish in all ofthe Great Lakes (University ofWisconsin Sea Grant Institute 2002). It is thought that TFM targets the mitochondria and uncouples oxidative phosphorylation, whichresults in the lampreys not being able to meettheir energy demands (Wilkie, et al. 2010). These products are only for sale to certified applicators ofthe U.S. Fish and Wildlife Services, Fisheries and Oceans Canada, and provincial and state fish and game employees. 

### USE SITES Agricultural Use Sites TFM is not labeled for use on any agricultural site. Non-Agricultural Use Sites TFM is labeled for use on lakes and streams only.


### COMMON FORMULATIONS AND APPLICATION METHODS TFM is formulated as an impregnated material (solid bar) and as a soluble liquid concentrate. The solid bar is placed in the water and allowed to dissolve slowly. The liquid formulation is applied bymetered pump from the back ofa boat or by backpack sprayer.


### USAGE Our available data from proprietary data, USDAINASS, Kline and Company, Inc., and California DepartmentofPesticide Regulation databases did not show any uses for this chemical on either agricultural crops ornon-agricultural sites. The sea lamprey is an invasive species introduced into the Great Lakes. This blood-sucking fish has devastated the native fishes ofthe Great Lakes (University ofWisconsin Sea Grant Institute 2002). TFM is the lampricide used to control sea lamprey larvae in tributaries to the Great Lakes, the Finger Lakes and Lake Champlain (EPA 1999). The only other chemical registered for sea lamprey control is niclosamide, which is registered for deltatreatments (NYS Department ofEnvironmental Conservation 2011).

2mSTORY OF BEAD ASSESSMENTS FORTFM BEAD found no past assessments on this chemical in its databases. INFORMATION THAT MAY BE USEFUL FORBEAD'S FUTURE WORK ON TFM The sea lamprey is an.invasive, aggressive pest that has greatly impacted the native fish ofthe Great Lakes, and it is critical to control. TFM is the major lampricide used to control this major pest, is highly restricted to the tributaries ofthe Great Lakes, and can only be purchased and applied by certified applicators ofthe U.S. Fish and Wildlife Services, Fisheries and Oceans Canada, and provincial and state fish and game employees. Because ofthe restrictions of locations and personal BEAD does notpredict that further information will be needed at this time. REFERENCES EPA. 1999. TFM Fact Sheet. Found at: http://www.epa.gov /oppsrrdlIREDs/factsheets/3082fact.pdf NYS Department ofEnvironmental Conservation. 2011. Found at: http://www.dec.ny.gov/animalsI7240.html
. USDA. 2011. Sea lamprey. Sea lamprey control. Found at: http://www.invasivespeciesinfo.gov/aquatics/lamprey.shtml
. University ofWisconsin Sea Grant Institute. 2002. Sea lamprey. Found at: http://seagrant.wisc.edulgreatlakesfishlsealamprey.html
. Wilkie, M. P., Y. S. Wang, and G. B. McClelland. 2010. Modes oflampricide toxicity on larval lampreys and non-target fishes. Found at: http:/ /www.glfc.org!researchlreports/Wilkie2010.htm



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