[Federal Register Volume 75, Number 221 (Wednesday, November 17, 2010)]
[Notices]
[Pages 70248-70254]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2010-28818]


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ENVIRONMENTAL PROTECTION AGENCY

[EPA-HQ-OPPT-2009-0477; FRL-8848-7]


Endocrine Disruptor Screening Program; Second List of Chemicals 
for Tier 1 Screening

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

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SUMMARY: This document announces the second list of chemicals and 
substances for which EPA intends to issue test orders under the 
Endocrine Disruptor Screening Program (EDSP). EPA established the EDSP 
in response to section 408(p) of the Federal Food, Drug, and Cosmetic 
Act (FFDCA). This second list of chemicals expands the EDSP in an 
effort to include all pesticides, required by FFDCA, and adds priority 
drinking water chemicals into the program for screening as authorized 
by SDWA section 1457. Today's publication provides public notice of 
EPA's tentative decision-making in advance of the actual issuance of 
EDSP testing orders.

DATES: In order for the Agency to consider information and/or comments 
that may be relevant to the inclusion or exclusion of chemicals 
contained on the second EDSP list, this information and/or comments 
should be received by EPA on or before December 17, 2010.

ADDRESSES: Submit your comments, identified by docket identification 
(ID) number EPA-HQ-OPPT-2009-0477, by one of the following methods:
    <bullet> Federal eRulemaking Portal: http://www.regulations.gov. 
Follow the on-line instructions for submitting comments.
    <bullet> Mail: Document Control Office (7407M), Office of Pollution 
Prevention and Toxics (OPPT), Environmental Protection Agency, 1200 
Pennsylvania Ave., NW., Washington, DC 20460-0001.
    <bullet> Hand Delivery: OPPT Document Control Office (DCO), EPA 
East Bldg., Rm. 6428, 1201 Constitution Ave., NW., Washington, DC. 
Attention: Docket ID Number EPA-HQ-OPPT-2009-0477. The DCO is open from 
8 a.m. to 4 p.m.,

[[Page 70249]]

Monday through Friday, excluding legal holidays. The telephone number 
for the DCO is (202) 564-8930. Such deliveries are only accepted during 
the DCO's normal hours of operation, and special arrangements should be 
made for deliveries of boxed information.
    Instructions: Direct your comments to docket ID number EPA-HQ-OPPT-
2009-0477. EPA's policy is that all comments received will be included 
in the docket without change and may be made available on-line at 
http://www.regulations.gov, including any personal information 
provided, unless the comment includes information claimed to be 
Confidential Business Information (CBI) or other information whose 
disclosure is restricted by statute. Do not submit information that you 
consider to be CBI or otherwise protected through regulations.gov or e-
mail. The regulations.gov Web site is an ``anonymous access'' system, 
which means EPA will not know your identity or contact information 
unless you provide it in the body of your comment. If you send an e-
mail comment directly to EPA without going through regulations.gov, 
your e-mail address will be automatically captured and included as part 
of the comment that is placed in the docket and made available on the 
Internet. If you submit an electronic comment, EPA recommends that you 
include your name and other contact information in the body of your 
comment and with any disk or CD-ROM you submit. If EPA cannot read your 
comment due to technical difficulties and cannot contact you for 
clarification, EPA may not be able to consider your comment. Electronic 
files should avoid the use of special characters, any form of 
encryption, and be free of any defects or viruses.
    Docket: All documents in the docket are listed in the docket index 
available at http://www.regulations.gov. Although listed in the index, 
some information is not publicly available, e.g., CBI or other 
information whose disclosure is restricted by statute. Certain other 
material, such as copyrighted material, is not placed on the Internet 
and will be publicly available only in hard copy form. Publicly 
available docket materials are available either in the electronic 
docket at http://www.regulations.gov, or, if only available in hard 
copy, at the OPPT Docket. The OPPT Docket is located in the EPA Docket 
Center (EPA/DC) at Rm. 3334, EPA West Bldg., 1301 Constitution Ave., 
NW., Washington, DC. The EPA/DC Public Reading Room hours of operation 
are 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal 
holidays. The telephone number of the EPA/DC Public Reading Room is 
(202) 566-1744, and the telephone number for the OPPT Docket is (202) 
566-0280. Docket visitors are required to show photographic 
identification, pass through a metal detector, and sign the EPA visitor 
log. All visitor bags are processed through an X-ray machine and 
subject to search. Visitors will be provided an EPA/DC badge that must 
be visible at all times in the building and returned upon departure.

FOR FURTHER INFORMATION CONTACT: For technical information contact: 
William Wooge, Office of Science Coordination and Policy, Environmental 
Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460-
0001; telephone number: (202) 564-8476; e-mail address: 
<a href="/cdn-cgi/l/email-protection#2d5a42424a48035a444141444c406d485d4c034a425b"><span class="__cf_email__" data-cfemail="56213939313378213f3a3a3f373b1633263778313920">[email protected]</span></a>.
    For general information contact: The TSCA-Hotline, ABVI-Goodwill, 
422 South Clinton Ave., Rochester, NY 14620; telephone number: (202) 
554-1404; e-mail address: <a href="/cdn-cgi/l/email-protection#0e5a5d4d4f2346617a6267606b4e6b7e6f20696178"><span class="__cf_email__" data-cfemail="9bcfc8d8dab6d3f4eff7f2f5fedbfeebfab5fcf4ed">[email protected]</span></a>.

SUPPLEMENTARY INFORMATION:

I. General Information

A. Does this action apply to me?

    You may be potentially affected by this action if you produce, 
manufacture, use, consume, work with, or import substances included on 
the second EDSP list. Potentially affected entities may include, but 
are not limited to:
    <bullet> Chemical manufacturers, importers and processors (NAICS 
code 325), e.g., persons who manufacture, import or process chemical 
substances.
    <bullet> Pesticide, fertilizer, and other agricultural chemical 
manufacturers (NAICS code 3253), e.g., persons who manufacture, import 
or process pesticide, fertilizer and agricultural chemicals.
    <bullet> Scientific research and development services (NAICS code 
5417), e.g., persons who conduct testing of chemical substances for 
endocrine effects.
    This listing is not intended to be exhaustive, but rather provides 
a guide for readers regarding entities likely to be affected by this 
action. Other types of entities not listed in this unit could also be 
affected. The North American Industrial Classification System (NAICS) 
codes have been provided to assist you and others in determining 
whether this action might apply to certain entities. If you have any 
questions regarding the applicability of this action to a particular 
entity, consult the technical person listed under FOR FURTHER 
INFORMATION CONTACT.

B. What should I consider as I prepare my comments for EPA?

    1. Submitting CBI. Do not submit this information to EPA through 
regulations.gov or e-mail. Clearly mark the part or all of the 
information that you claim to be CBI. For CBI information in a disk or 
CD-ROM that you mail to EPA, mark the outside of the disk or CD-ROM as 
CBI and then identify electronically within the disk or CD-ROM the 
specific information that is claimed as CBI. In addition to one 
complete version of the comment that includes information claimed as 
CBI, a copy of the comment that does not contain the information 
claimed as CBI must be submitted for inclusion in the public docket. 
Information so marked will not be disclosed except in accordance with 
procedures set forth in 40 CFR part 2.
    2. Tips for preparing your comments. When submitting comments, 
remember to:
    i. Identify the document by docket ID number and other identifying 
information (subject heading, Federal Register date and page number).
    ii. Follow directions. The Agency may ask you to respond to 
specific questions or organize comments by referencing a Code of 
Federal Regulations (CFR) part or section number.
    iii. Explain why you agree or disagree; suggest alternatives and 
substitute language for your requested changes.
    iv. Describe any assumptions and provide any technical information 
and/or data that you used.
    v. If you estimate potential costs or burdens, explain how you 
arrived at your estimate in sufficient detail to allow for it to be 
reproduced.
    vi. Provide specific examples to illustrate your concerns and 
suggest alternatives.
    vii. Explain your views as clearly as possible, avoiding the use of 
profanity or personal threats.
    viii. Make sure to submit your comments by the comment period 
deadline identified.

II. Introduction

A. What action is the agency taking?

    Today's document announces the second list of chemicals that the 
Agency intends to include in its EDSP. Through the issuance of orders, 
the Agency intends to require the submission of Tier 1 Screening data 
for these chemicals. Elsewhere in today's issue of the Federal 
Register, EPA also is announcing the policies and procedures expected 
to be followed for certain chemicals on this list. Information on EDSP 
and Tier 1 Screening data is

[[Page 70250]]

available on the Agency's Web site at http://www.epa.gov/endo.

B. What is the agency's authority for taking this action?

    EPA's authority for taking this action is based on several 
different Congressional actions, including FFDCA, the Safe Drinking 
Water Act (SDWA), and the House Appropriations Committee report for 
EPA's FY 2010 appropriations.
    EPA developed the EDSP in 1998 to implement FFDCA section 408(p), 
which requires EPA to ``develop a screening program, using appropriate 
validated test systems and other scientifically relevant information, 
to determine whether certain substances may have an effect in humans 
that is similar to an effect produced by a naturally occurring 
estrogen, or such other endocrine effect as [EPA] may designate.'' (21 
U.S.C. 346a(p)). The statute generally requires EPA to ``provide for 
the testing of all pesticide chemicals'' and gives EPA discretionary 
authority to ``provide for the testing of any other substance that may 
have an effect that is cumulative to an effect of a pesticide chemical 
if the Administrator determines that a substantial population may be 
exposed to such a substance.'' (21 U.S.C. 346a(p)(3)). The statute also 
authorizes EPA to exempt a chemical upon a determination that ``the 
substance is anticipated not to produce any effect in humans similar to 
an effect produced by a naturally occurring estrogen.'' (21 U.S.C. 
346a(p)(4)).
    Section 1457 of SDWA provides that ``in addition to the 
substances'' referred to in FFDCA section 408(p)(3)(B), ``the 
Administrator may provide for testing under the screening program 
authorized by section 408(p) of such Act, in accordance with the 
provisions of section 408(p) of such Act, of any other substance that 
may be found in sources of drinking water if the Administrator 
determines that a substantial population may be exposed to such 
substance.'' (42 U.S.C. 300j-17). EPA used its authority under SDWA to 
identify a portion of the chemicals on the second EDSP list.
    In addition, in Congress's House Appropriations Committee report 
for EPA's FY 2010 appropriations (H.R. 2996, H. Rept. 111-180) (Ref. 
1), it directed EPA ``to publish within 1 year of enactment a second 
list of no less than 100 chemicals for screening that includes drinking 
water contaminants, such as halogenated organic chemicals, dioxins, 
flame retardants (PBDEs, PCBs, PFCs), plastics (BPA), pharmaceuticals 
and personal care products, and issue 25 orders per year for the 
testing of these chemicals.''

III. Background

    EPA developed EDSP in response to a Congressional mandate in FFDCA 
``to determine whether certain substances may have an effect in humans 
that is similar to an effect produced by a naturally occurring 
estrogen, or such other endocrine effect as [EPA] may designate'' (21 
U.S.C. 346a(p)). As part of EDSP, EPA issues orders to collect certain 
test data on listed chemical substances. Unit II.B. describes the 
authority for listing a chemical. Test data requirements are derived 
from specific test assays, which are divided into two tiers. Tier I 
test assays are used to screen the chemicals for interaction with the 
estrogen (E), androgen (A) or thyroid (T) hormonal systems. Tier II 
test assays are intended to test for more specific chemical effects on 
the endocrine system, and are currently in the process of being 
developed and validated. Further information regarding EDSP and 
requirements for Tier I and Tier II can be found on the Agency's EDSP 
Web site, at http://www.epa.gov/endo/.

IV. Development of the Second EDSP List

    In developing the second EDSP list, EPA focused on a subset of 
chemicals and substances that have been listed as priorities within 
EPA's drinking water and pesticides programs. While the Agency has not 
included some chemicals or substances on the second EDSP list as 
explained in Unit IV.A., non-inclusion does not mean that these other 
chemicals or substances may not be subject to testing in the near term 
nor in the future. In addition, based on current information, the 
public should not presume that the listing of a chemical or substance 
indicates in any way that EPA currently suspects that such chemical or 
substance interferes with the endocrine systems of humans or other 
species simply because it has been listed for screening under the EDSP. 
At the present time, EPA believes that these chemicals or substances 
should be candidates, at least for screening purposes, under EDSP 
testing based only on their pesticide registration status and/or 
because such substances may occur in sources of drinking water to which 
a substantial population may be exposed.

A. Basis for Chemical Selection

    The Agency considered chemicals contained on the Office of Water 
(OW) and Office of Pesticide Programs (OPP) priority lists for 
inclusion on the second EDSP list.
    1. Initial compilation of OW candidate chemicals. The Agency 
identified candidate chemicals that are either contaminants regulated 
with a national primary drinking water regulation (NPDWR) (40 CFR part 
141) (Ref. 2) or are unregulated contaminants that are listed on the 
third Contaminant Candidate List (CCL 3) (USEPA, 2009) (Ref. 3). EPA 
began with the 85 regulated drinking water contaminants with existing 
NPDWRs and the 116 unregulated contaminants listed on CCL 3 because 
these represent many of the priority contaminants for the drinking 
water program. Most of the regulated drinking water contaminants with 
NPDWRs were designated by Congress under the 1986 or the1996 SDWA 
amendments. Because Congress designated these contaminants for 
regulation due to concerns about occurrence in drinking water and 
adverse impacts on human health, EPA believes that each such substance 
meets the statutory testing criteria from SDWA section 1457. SDWA 
section 1412(b)(9) requires the Agency to periodically review the 
existing NPDWRs and revise them, if appropriate. Information about the 
potential for endocrine disruption will assist the Agency in updating 
human health assessments, which the Agency considers in its periodic 
review of NPDWRs to ensure that they are protective of human health.
    SDWA section 1412(b)(1) requires the Agency to develop a list of 
unregulated contaminants that are known or anticipated to occur in 
public water systems (PWSs) and may require regulation under SDWA. The 
Agency is required to develop the CCL list every 5 years. In 
determining whether a substance may occur in drinking water, EPA 
considers not only public water system monitoring data, but also data 
on ambient concentrations in surface water and ground water, and 
releases to the environment (e.g., reporting data from the Toxics 
Release Inventory). The Agency believes that such data are sufficient 
to anticipate contaminants that may occur in public water systems and 
furthermore, also represent those substances that may be found in 
sources of drinking water and to which a substantial population may be 
exposed. In selecting contaminants for the CCL, SDWA section 
1412(b)(1)(C) requires that the Agency ``take into consideration, among 
other factors of public health concern, the effect of such contaminants 
upon subgroups that comprise a meaningful portion of the general 
population (such as infants, children, pregnant women, the elderly,

[[Page 70251]]

individuals with a history of serious illness, or other subpopulations) 
that are identifiable as being at greater risk of adverse health 
effects due to exposure to contaminants in drinking water than the 
general population.'' The protocol that EPA used to develop CCL 3 was 
reviewed by internal experts, as well as external experts such as the 
National Drinking Water Advisory Council and the Science Advisory Board 
(Ref. 3). The CCL 3 has undergone a rigorous listing and expert review 
process, including a public nomination and comment period, and 
therefore, represent an excellent source of potential drinking water 
candidates to consider for EDSP screening. The information about the 
potential for endocrine disruption will assist the Agency in evaluating 
the human health impacts of unregulated drinking water contaminants. In 
the CCL listing, EPA already has made the component of the SDWA section 
1457 determination that such substances may occur in sources of 
drinking water. The final CCL 3 listing also represents EPA's 
determination that a substantial population may be exposed to such 
substance for the purposes of SDWA 1457.
    In listing drinking water contaminants on the CCL 3, EPA closely 
evaluated the nature of the occurrence and prevalence information 
supporting each such CCL 3 listing. Evaluating occurrence, EPA 
considered and evaluated data based on occurrence in finished drinking 
water and ambient water, as well as based on total releases to the 
environment, pesticide application rates, and production volumes (73 FR 
9628, February 21, 2008) (FRL-8529-7). In deciding whether to move a 
possible drinking water contaminant from the preliminary CCL 3 to the 
proposed CCL 3, EPA scored each such contaminant based on, among other 
attributes, its occurrence attributes (at 73 FR 9640-41, February 21, 
2008). The occurrence attributes were weighted more heavily based on a 
hierarchy representing prevalence of the contaminant in the water 
environment or likely release to the water environment. The results of 
that scoring are described at 73 FR 9644, February 21, 2008. The 
administrative record supporting the CCL 3 ultimately published in 2009 
includes contaminant-by-contaminant information sheets that document 
the occurrence data upon which EPA relied for the listing of CCL 3 
contaminants. The basis for EPA's inclusion of the CCL 3 contaminants 
on its tentative testing list, therefore, also provides the basis for 
EPA's determination that a substantial population may be exposed to 
each such substance for the purposes of SDWA section 1457.
    2. Initial compilation of OPP candidate chemicals. The Agency 
identified candidate chemicals from OPP based on pesticides that were 
scheduled for Registration Review during fiscal years 2007 and 2008. 
This selection is part of the Agency's intent to efficiently expedite 
the testing of pesticides by conducting the testing in parallel or as 
part of the OPP Registration Review program.
    3. Streamlining the second EDSP list. Consolidating the lists of OW 
and OPP chemicals resulted in over 200 chemicals. A listing of these 
chemicals is available in the docket for this notice (Ref. 4). The 
Agency streamlined this initial second EDSP list by excluding any 
chemical that fell into one or more of the following categories:
    i. Biological agent and naturally occurring chemicals (e.g., 
microbials, microbial toxins, inorganics, radionuclides).
    ii. Chemicals for which the manufacturer, importer or registrant 
cannot be clearly identified (e.g., disinfection byproducts or DBPs, 
microbes, microbial toxins, degradate compounds with more than one 
possible source).
    iii. Chemicals already included on the first EDSP list because 
these chemicals have already received an EDSP order. Note however that 
if no one agreed to provide data in response to that order, additional 
orders may be issued under a SDWA determination.
    iv. Chemicals that are hormones with confirmed endocrine effects.
    v. Chemicals not likely to be biologically active or which are 
incompatible with testing assays for various reasons due to one or more 
of their physiochemical properties (e.g., gases, strongly acidic or 
basic, solubility, vapor pressure molecular weight).
    vi. Pesticides that are scheduled for registration review after FY 
2008.
    Although these chemicals have been excluded from the second EDSP 
list for one or more of these reasons, it is important to note that 
these exclusions do not imply that the Agency has no interest in the 
potential for endocrine disruption activity for these chemicals. In 
some instances, the Agency recognizes that information on endocrine 
effects is already available (e.g., for the hormones) or the Agency is 
currently collecting information (e.g., through the first EDSP list). 
In other cases, the Agency simply realizes that at this time there is 
some difficulty with collecting the information about endocrine effects 
through the EDSP (i.e., because of the Agency's inability to identify a 
manufacturer, importer, or registrant or because the contaminant is 
incompatible with the testing assays). In addition, EPA recognizes that 
some of the naturally occurring chemicals also have anthropogenic 
sources and should be considered for the EDSP. In no way should it be 
inferred that removal from this initial second EDSP list signifies that 
a chemical does not have the potential to be placed on a future EDSP 
chemical list. The Agency intends to reexamine currently excluded 
chemicals for future EDSP chemical lists.
    EPA is interested in receiving information from the public that may 
help the Agency resolve the difficulties with the currently excluded 
chemicals so that the Agency will be able to consider adding them to 
future EDSP chemical lists.

B. Second EDSP List of Chemicals

    There are approximately 134 chemicals on the second ESDP list (see 
Table 1). This list includes a large number of pesticides, two 
perfluorocarbon compounds (PFCs), and three pharmaceuticals 
(erythromycin, nitroglycerin, and quinoline). This list also consists 
of an array of other chemicals, ranging from those used for industrial 
manufacturing processes, as plasticizers, or in the production of 
pharmaceutical and personal care products (PPCPs).
    EPA is interested in receiving information and/or comment that may 
inform the exclusion or inclusion of chemicals on the second EDSP list. 
The Agency does not plan to respond formally to information or comments 
that may be submitted on this document, but will add such information 
to the notice docket as public record. EPA will consider such 
information and/or comment before finalizing the second EDSP list and 
publishing the Schedule for Issuance of Orders along with the second 
EDSP list. In addition, please note that by relying on the CCL 3 as 
part of this effort, the Agency does not intend to re-open CCL 3 for 
public comment or any of the individual lists used to create the second 
list of EDSP chemicals and does not intend to respond to any such 
comments so submitted.

[[Page 70252]]



                           Table 1--Second EDSP List of Chemicals for Tier 1 Screening
----------------------------------------------------------------------------------------------------------------
                    Chemical name                          CAS number        SDWA         PAI       RR schedule
----------------------------------------------------------------------------------------------------------------
1,1,1,2-Tetrachloroethane............................           630-20-6          X   ..........  ..............
1,1,1-Trichloroethane................................            71-55-6          X   ..........  ..............
1,1,2-Trichloroethane................................            79-00-5          X   ..........  ..............
1,1-Dichloroethane...................................            75-34-3          X   ..........  ..............
1,1-Dichloroethylene.................................            75-35-4          X   ..........  ..............
1,2,3-Trichloropropane...............................            96-18-4          X   ..........  ..............
1,2,4-Trichlorobenzene...............................           120-82-1          X   ..........  ..............
1,2-Dibromo-3-chloropropane (DBCP)...................            96-12-8          X   ..........  ..............
1,2-Dichloroethane...................................           107-06-2          X   ..........  ..............
1,2-Dichloropropane..................................            78-87-5          X   ..........  ..............
1,3-Dinitrobenzene...................................            99-65-0          X   ..........  ..............
1,4-Dioxane..........................................           123-91-1          X   ..........  ..............
1-Butanol............................................            71-36-3          X   ..........  ..............
2,4,5-TP (Silvex)....................................            93-72-1          X   ..........  ..............
2-Methoxyethanol.....................................           109-86-4          X   ..........  ..............
2-Propen-1-ol........................................           107-18-6          X   ..........  ..............
4,4'-Methylenedianiline..............................           101-77-9          X   ..........  ..............
Acetaldehyde.........................................            75-07-0          X   ..........  ..............
Acetamide............................................            60-35-5          X   ..........  ..............
Acetochlor...........................................         34256-82-1          X           X   ..............
Acetochlor ethanesulfonic acid (ESA).................        187022-11-3          X   ..........  ..............
Acetochlor oxanilic acid (OA)........................        194992-44-4          X   ..........  ..............
Acrolein.............................................           107-02-8          X           X   ..............
Acrylamide...........................................            79-06-1          X   ..........  ..............
Alachlor.............................................         15972-60-8          X           X   ..............
Alachlor ethanesulfonic acid (ESA)...................        142363-53-9          X   ..........  ..............
Alachlor oxanilic acid (OA)..........................        171262-17-2          X   ..........  ..............
alpha-Hexachlorocyclohexane..........................           319-84-6          X   ..........  ..............
Aniline..............................................            62-53-3          X   ..........  ..............
Bensulide............................................           741-58-2          X           X          FY 2008
Benzene..............................................            71-43-2          X   ..........  ..............
Benzo(a)pyrene (PAHs)................................            50-32-8          X   ..........  ..............
Benzyl chloride......................................           100-44-7          X   ..........  ..............
Butylated hydroxyanisole.............................         25013-16-5          X   ..........  ..............
Carbon tetrachloride.................................            56-23-5          X   ..........  ..............
Chlordane............................................            57-74-9          X   ..........  ..............
Chlorobenzene........................................           108-90-7          X   ..........  ..............
cis-1,2-Dichloroethylene.............................           156-59-2          X   ..........  ..............
Clethodim............................................         99129-21-2          X           X          FY 2008
Clofentezine.........................................         74115-24-5  ..........          X          FY 2007
Clomazone............................................         81777-89-1  ..........          X          FY 2007
Coumaphos............................................            56-72-4  ..........          X          FY 2008
Cumene hydroperoxide.................................            80-15-9          X   ..........  ..............
Cyanamide............................................           420-04-2  ..........          X          FY 2008
Cyromazine...........................................         66215-27-8  ..........          X          FY 2007
Dalapon..............................................            75-99-0          X   ..........  ..............
Denatonium saccharide................................         90823-38-4  ..........          X          FY 2008
Di(2-ethylhexyl) adipate.............................           103-23-1          X   ..........  ..............
Dichloromethane......................................            75-09-2          X   ..........  ..............
Dicrotophos..........................................           141-66-2          X           X          FY 2008
Dimethipin...........................................         55290-64-7          X           X   ..............
Dinoseb..............................................            88-85-7          X   ..........  ..............
Diuron...............................................           330-54-1          X           X   ..............
Endothall............................................           145-73-3          X           X   ..............
Endrin...............................................            72-20-8          X   ..........  ..............
Epichlorohydrin......................................           106-89-8          X   ..........  ..............
Erythromycin.........................................           114-07-8          X   ..........  ..............
Ethylbenzene.........................................           100-41-4          X   ..........  ..............
Ethylene dibromide...................................           106-93-4          X   ..........  ..............
Ethylene glycol......................................           107-21-1          X   ..........  ..............
Ethylene thiourea....................................            96-45-7          X   ..........  ..............
Ethylurethane........................................            51-79-6          X   ..........  ..............
Etofenprox...........................................         80844-07-1  ..........          X          FY 2007
Fenamiphos...........................................         22224-92-6          X           X          FY 2008
Fenarimol............................................         60168-88-9  ..........          X          FY 2007
Fenoxaprop-P-ethyl...................................         71283-80-2  ..........          X          FY 2007
Fenoxycarb...........................................         72490-01-8  ..........          X          FY 2007
Flumetsulam..........................................         98967-40-9  ..........          X          FY 2008
Fomesafen sodium.....................................        108731-70-0  ..........          X          FY 2007
Fosetyl-Al (Aliette).................................         39148-24-8  ..........          X          FY 2008
Glufosinate ammonium.................................         77182-82-2  ..........          X          FY 2008
HCFC-22..............................................            75-45-6          X   ..........  ..............

[[Page 70253]]

 
Heptachlor...........................................            76-44-8          X   ..........  ..............
Heptachlor epoxide...................................          1024-57-3          X   ..........  ..............
Hexachlorobenzene....................................           118-74-1          X   ..........  ..............
Hexachlorocyclopentadiene............................            77-47-4          X   ..........  ..............
Hexane...............................................           110-54-3          X   ..........  ..............
Hexythiazox..........................................         78587-05-0  ..........          X          FY 2007
Hydrazine............................................           302-01-2          X   ..........  ..............
Isoxaben.............................................         82558-50-7  ..........          X          FY 2008
Lactofen.............................................         77501-63-4  ..........          X          FY 2007
Lindane..............................................            58-89-9          X   ..........  ..............
Methanol.............................................            67-56-1          X   ..........  ..............
Methoxychlor.........................................            72-43-5          X   ..........  ..............
Methyl tert-butyl ether..............................          1634-04-4          X   ..........  ..............
Metolachlor ethanesulfonic acid (ESA)................        171118-09-5          X   ..........  ..............
Metolachlor oxanilic acid (OA).......................        152019-73-3          X   ..........  ..............
Molinate.............................................          2212-67-1          X   ..........  ..............
Nitrobenzene.........................................            98-95-3          X   ..........  ..............
Nitroglycerin........................................            55-63-0          X   ..........  ..............
N-Methyl-2-pyrrolidone...............................           872-50-4          X   ..........  ..............
N-Nitrosodimethylamine (NDMA)........................            62-75-9          X   ..........  ..............
n-Propylbenzene......................................           103-65-1          X   ..........  ..............
o-Dichlorobenzene....................................            95-50-1          X   ..........  ..............
o-Toluidine..........................................            95-53-4          X   ..........  ..............
Oxirane, methyl-.....................................            75-56-9          X   ..........  ..............
Oxydemeton-methyl....................................           301-12-2          X           X          FY 2008
Oxyfluorfen..........................................         42874-03-3          X           X   ..............
Paclobutrazol........................................         76738-62-0  ..........          X          FY 2007
p-Dichlorobenzene....................................           106-46-7          X           X   ..............
Pentachlorophenol....................................            87-86-5          X           X   ..............
Perchlorate..........................................         14797-73-0          X   ..........  ..............
Perfluorooctane sulfonic acid (PFOS).................          1763-23-1          X   ..........  ..............
Perfluorooctanoic acid (PFOA)........................           335-67-1          X   ..........  ..............
Picloram.............................................          1918-02-1          X           X   ..............
Polychlorinated biphenyls............................          1336-36-3          X   ..........  ..............
Profenofos...........................................         41198-08-7          X           X          FY 2008
Propetamphos.........................................         31218-83-4  ..........          X          FY 2008
Propionic acid.......................................            79-09-4  ..........          X          FY 2008
Pyridate.............................................         55512-33-9  ..........          X          FY 2007
Quinclorac...........................................         84087-01-4  ..........          X          FY 2008
Quinoline............................................            91-22-5          X   ..........  ..............
Quizalofop-P-ethyl...................................        100646-51-3  ..........          X          FY 2008
RDX..................................................           121-82-4          X   ..........  ..............
sec-Butylbenzene.....................................           135-98-8          X   ..........  ..............
Sodium tetrathiocarbonate............................          7345-69-9  ..........          X          FY 2008
Styrene..............................................           100-42-5          X   ..........  ..............
Sulfosate............................................         81591-81-3  ..........          X          FY 2007
Temephos.............................................          3383-96-8  ..........          X          FY 2008
Terbufos.............................................         13071-79-9          X           X          FY 2008
Terbufos sulfone.....................................         56070-16-7          X   ..........  ..............
Tetrachloroethylene..................................           127-18-4          X   ..........  ..............
Thiophanate-methyl...................................         23564-05-8          X           X   ..............
Toluene diisocyanate.................................         26471-62-5          X   ..........  ..............
Toxaphene............................................          8001-35-2          X   ..........  ..............
trans-1,2-Dichloroethylene...........................           156-60-5          X   ..........  ..............
Trichloroethylene....................................            79-01-6          X   ..........  ..............
Triethylamine........................................           121-44-8          X   ..........  ..............
Triflumizole.........................................         68694-11-1  ..........          X          FY 2007
Trinexapac-ethyl.....................................         95266-40-3  ..........          X          FY 2008
Triphenyltin hydroxide (TPTH)........................            76-87-9          X           X   ..............
Vinclozolin..........................................         50471-44-8          X           X   ..............
Xylenes (total)......................................          1330-20-7          X           X   ..............
Ziram................................................           137-30-4          X           X   ..............
----------------------------------------------------------------------------------------------------------------
CAS Number = Chemical Abstract Services Registry Number.
SDWA = Drinking water chemical based on CCL 3 List or chemicals with National Primary Drinking Water
  Regulations.
PAI = Pesticide active ingredient (Current pesticide registration exists).
RR = OPP Registration Review date.


[[Page 70254]]

V. References

    The following is a list of the documents that are specifically 
referenced in this document. These references are available in the 
docket number identified under General Information (Section I.B).

    1. U.S. Congress. House Report 111-180. Available at: http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=111congreports&docid=f:hr180.111.pdf.
    2. USEPA. 2009. National Primary Drinking Water Regulations. May 
2009. EPA 816-F-09-004. Available at: http://www.epa.gov/safewater/consumer/pdf/mcl.pdf.
    3. USEPA. 2009. Drinking Water Contaminant Candidate List 3--
Final Notice. Federal Register. Vol, 74. No 194. p. 51850. October 
8, 2009.
    4. Initial Compilation of Chemicals and Substances Considered 
for the Second Endocrine Disruptor Screening Program List.

List of Subjects

    Environmental protection, Chemicals, Drinking water, Endocrine 
disruptors, Pesticides.

    Dated: September 28, 2010.
Steve A. Owens,
Assistant Administrator, Office of Chemical Safety and Pollution 
Prevention.
[FR Doc. 2010-28818 Filed 11-16-10; 8:45 am]
BILLING CODE 6560-50-P


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