# Aldicarb Dietary Risk Assessment Summary

July 2010

I. Hazard Assumptions

 Point of Departure based on Human Study; BMDL 10 

# = 0.013 mg/kg/day

 Intra-species Uncertainty Factor = 10

 FQPA Safety Factor from new CCA PND11 St udy; comparison of RBC cholinesterase

inhibition for male rats and pups

 Revised FQPA Safety Factor = 4.8

 Population Adjusted Dose = 0.00027 mg/kg/day

II. Food & Water Exposure Assumptions; Usage Assumptions

A. Food Exposure Assumptions

 Probabilistic Analysis

 Residues are the combined residues of aldicar b, aldicarb sulfoxide, and aldicarb sulfone

(calculated as aldicarb)

 PDP Data

o Composite Data used in Risk Assessment (RA) (see Table 1 for years and total

number of samples)

o Single Serving Data from PDP and Carbamate Task Force were NOT used

 Orange juice data translated to grapefruit juice, lemon juice, and lime juice

 Field Trial Data: used for pecans, peanuts, cottonseed, dry beans, sugar beets, soybeans,

sorghum, sugarcane, pecans, coffee (alt hough some uses were voluntarily cancelled

during the RED process, scenarios where run since tolerances still exist for them)

Table 1. Summary of Composite Data Used in Risk Assessment

Commodity Years of PDP Data Used Total No. of Samples Total No. of Detects

Potatoes 2000-2002; 2008 2216 57

Frozen Potatoes (Partially Cooked

French Fries 2006-2007 1544 93

Sweet Potatoes 2003-2004, 2008 1657 17

Oranges 2000-2001, 2004-2005 2972 9

Orange Juice 2004-2006 1487 46

Grapefruit 2005-2006 430 4



# Table 2. Summary of Empirical Processing Factors

Commodity/Processed Food Form Processing Factor

Potatoes: dried and cooked food forms 0.3

Potatoes: fried forms (with and without peel) 0.62

Potatoes: fried and dried food forms 0.19

Potatoes: boiled and cooked 0.5

Potatoes: boiled/cooked and dried food forms 0.15

Beans, dry 0.05

Peanut/oil 0.18

Soybean/oil 0.3

Cottonseed/oil 0.1

Sugarcane/sugar beet Residues assumed to be zero



# Page 1 of 8

# B. Water Exposure Assumptions

 The Agency used PRZM for estimated dri nking water concentrations for groundwater

 Scenario leading to the highest concentra tions was Georgia Cotton/Peanut at maximum

application rates, assuming a 500 ft. well set-back

 Also conducted analyses using the North Ca rolina Cotton/Peanut scenario at maximum

application rates, assuming a 300 ft. well set-back

 The Agency used groundwater monitoring data to qualitatively va lidate the estimated

drinking water concentrations from groundwater identified using PRZM

C. Usage Assumptions

 Screening Level Usage Analysis (dated 4/15/10) was used

 Same percent crop treated assumed for fresh and processed commodities

III. Risk Assumptions & Characterization

A. Risk Assumptions

 Refined using Eating Occasion Analysis

 Human recovery data indicate 2 hour half-life for adults

 New CCA study did not indicate si gnificant differences in rec overy rates between adults

and pups at lower doses

 Assessed assuming 1 minute a nd 120 minute half-lives

B. Risk Characterization

 Inclusion of commodities cancelled in the RED does not materially affect the risk.

 Food exposure is the risk driver for children ages 1-2 and 3-5.

o Potatoes and citrus are the greate st contributors to food exposure.

 Water is the most significant contributor to exposure of infants.

o The use of aldicarb in the southeast U. S. on citrus, peanuts, cotton and soybeans

leads to the greatest exposure in drinking water.

 Additional characterization runs, assuming zer o residues for all samples included as 1⁄2

limit of detection for the thr ee analytes, were conducted.

Table 3. Risk Results – 99.9 th 

# Percentile; No Recovery Assumed

*Bolded values indicate dietar y exposures exceeding the leve l of concern, 100% of the aPAD

Food Alone Food and Drinking Water/ GA

Cotton/Peanut Scenario

Population Subgroup aPAD

(mg/kg/day) Exposure

(mg/kg/day) % aPAD as

aldicarb Exposure

(mg/kg/day) % aPAD as

aldicarb

General U.S. Population 0.00031 0.000423 160 0.00176 650

All Infants (< 1 year old) 0.00031 0.000731 270 0.00428 1600

Children 1-2 years old 0.00031 0.000866 320 0.00218 810

Children 3-5 years old 0.00031 0.000737 270 0.00195 720

Children 6-12 years old 0.00031 0.000459 150 0.00127 470

Youth 13-19 years old 0.00031 0.000370 140 0.00133 500

Adults 20-49 years old 0.00031 0.000312 120 0.00138 510



# Page 2 of 8

# Food Alone Food and Drinking Water/ GA

Cotton/Peanut Scenario aPAD Population Subgroup (mg/kg/day) Exposure % aPAD as Exposure % aPAD as

(mg/kg/day) aldicarb (mg/kg/day) aldicarb

Adults 50+ years old 0.00031 0.000289 110 0.00103 380

Females 13-49 years old 0.00031 0.000304 110 0.00134 500



# Table 4. Results of Eating Occasion Risk Assessment at Various Recovery Rates

Scenario 1 m Eating

Occasion % aPAD

99.9 1 

# 120 m Eating

Occasion % aPAD

99.9 2



# INFANTS

Food and Water; existing uses GA 500ft 800% 810%

Food alone existing uses 220% 220%

Food alone; RED commodities removed 220% 230%

Food alone; potatoes removed 130% 130%

Food alone; potatoes and sweet potatoes removed 120% 120%

Food alone; citrus commodities removed 130% 130%

Food alone; citrus and potato commodities removed 15% 15%

Food and water; citrus and potato commodities removed; GA 500 ft 790% 800%

Food and water; citrus and potato commodities removed; NC 300 ft 250% 250%

CHILDREN AGES 1-2

Food and Water; existing uses GA 500ft 430% 440%

Food alone existing uses 270% 290%

Food alone; RED commodities removed 280% 290 %

Food alone; potatoes removed 220% 220%

Food alone; potatoes and sweet potatoes removed 220% 220%

Food alone; citrus commodities removed 210% 210%

Food alone; citrus and potato commodities removed 9% 9%

Food and water; citrus and potato commodities removed; GA 500 ft 300 330

Food and water; citrus and potato commodities removed; NC 300 ft

94% 100%

CHILDREN AGES 3-5

Food and Water; existing uses GA 500ft 340% 360%

Food alone existing uses 230% 230%

Food alone; RED commodities removed 230% 230%

Food alone; potatoes removed 130% 140%

Food alone; potatoes and sweet potatoes removed 130% 140%

Food alone; citrus commodities removed 190% 190%

Food alone; citrus and potato commodities removed 7% 7%

Food and water; citrus and potato commodities removed; GA 500 ft 260% 290%

Food and water; citrus and potato commodities removed; NC 300 ft 84% 92%

1 

# The Agency historically does not assume a one minute recovery rate in pesticide dietary exposure and risk assessments.

However, a one minute recovery rate was included in this asse ssment to demonstrate that the length of the half-life time

does not substantively affect dietary exposu re of aldicarb to infants and children.

2 

# 120 minute half-life based on human recovery data.



# Page 3 of 8

# Page 4 of 8 Table 5. Additional Characterization Runs

*Assuming zero residues for all samples included as 1⁄2 limit of detection for three analytes

*Bolded values indicate dietar y exposures exceeding the leve l of concern, 100% of the aPAD

Food Alone Food alone

Assuming zeros

for non Detects for

Potatoes Food alone

Assuming zeros

for non Detects for

Potatoes and

Citrus Food alone

Assuming zeros

for non Detects for

Citrus; potatoes

removed Population Subgroup

NR 1 

# 2 hr 1 

# NR 1 

# 2 hr 1 

# NR 1 

# 2 hr 1 

# NR 1 

# 2 hr 1



# General U.S. Population 160

-- 150 -- 120 -- 42

--

All Infants (< 1 year old) 270 22 0 210 220 94 90 39 1

Children 1-2 years old 320 290 310 29 0 240 23 0 13 0 38

Children 3-5 years old 270 230 270 22 0 210 18 0 92 39

Children 6-12 years old 170

-- 170 -- 140 -- 59

--

Youth 13-19 years old 140

-- 120 -- 110 -- 44

--

Adults 20-49 years old 120

-- 110 -- 100 -- 31

--

Adults 50+ years old 110

-- 110 -- 100 -- 25

--

Females 13-49 years old 110 -- 110

-- 94

-- 34

--

1 

# NR = %aPAD directly from DEEMTM. 2 hr. = %aPAD assuming 2 hour 1⁄2 life.



# IV. Commodity Specific (Eaters Only) Analyses

 Margins of exposure (MOE) greater than 48 would not be of concern

Table 6. Commodity Specific (Eaters Only) Analysis – Children 1-2

Amount food

consumed, g/kg

BW/day Max Aldicarb

Residue, ppm

(PDP Composite) Mg

aldicarb/ kg

BW/day MOE

50 th 

# percentile of Consumption, Baked potato 3.2 0.49 0.00156 8

90 th 

# percentile of Consumption, Baked potato 11.8 0.49 0.0058 2

50 th 

# percentile of Consumption, Fried Potatoes 2.77 0.051 0.000142 92

90 th 

# percentile of Consumption, Fried Potatoes 5.55 0.051 0.000283 46

50 th 

# percentile of Consumption, Orange Juice 14.1 1 

# 0.0167 0. 000236 55

90 th 

# percentile of Consumption, Orange Juice 31.4 0.0167 0.000524 25

Mg aldicarb/kg BW/day = amount food x max aldicarb residue/1000

MOE = BMDL 10 

# /mg aldicarb day

MOE should be greater than 48; bold ed MOEs indicate MOEs of concern

1 

# A 15 kg (~33 lb) child drinking 8 oz. (~250 g) would have a consumption of 16.7 g OJ/kg BW.

Notes:

Baked Potato Food Form: Potato, tuber w/o peel, cooked, fresh, baked

Fried Potato Food Form: Potato, tuber, w/o peel, cooked, frozen, fried

Orange Juice Food Form: Orange, ju ice, uncooked, fresh, not specified

No processing factors were appliedAppendix I. Summary of PDP Data for Aldicarb, Aldicarb Sulfoxide,and Aldicarb SulfoneYearNo. of SampleswithDetectableResiduesTotal No.of SamplesAnalyzedDetectRateMaxPCTAverageAldicarbLODAverageSulfoxideLODAverageSulfoneLODAverageCombined1⁄2 LODsRange ofAldicarbDetects (No.of Detects)Range of AldicarbSulfoxide Detects(No. of Detects)Range ofAldicarb SulfoneDetects (No. ofDetects)Potatoes2008307444.0150.003570.002990.004150.00494N/A0.002-0.062 (14)0.002-0.34 (30)2002123703.2150.01770.03440.03270.0387N/A0.045-0.186 (12)0.035-0.062 (2)2001127331.6150.01770.03450.03500.0398N/A0.045-0.43 (12)0.035-0.11 (9)200033690.8150.01770.05270.05950.0587N/A0.045-0.32 (3)0.035-0.125 (2)Frozen Potatoes2007328004.0150.002770.002840.003320.00412N/A0.002 - 0.021 (31)0.002 - 0.004 (14)2006617448.2150.002820.002220.003430.00390N/A0.002 - 0.039 (60)0.002 - 0.02 (23)Sweet Potatoes200811840.550.009120.008530.009710.0127N/A0.041 (1)0.027 (1)200487391.150.009120.002590.004060.00749N/A0.0027-0.077 (8)0.003-0.06 (7)200387341.150.01030.008970.007510.0125N/A0.0027-0.083 (8)0.003-0.023 (4)Grapefruit200642161.8550.007080.0050.0090.00971N/A0.008 - 0.063 (4)N/A200502140550.0070.006990.007010.00973N/AN/AN/AOrange200527410.3350.009100.008540.009710.0126N/A0.0304, 0.0147N/A200407420350.01060.01490.01560.0188N/AN/AN/A200147450.5350.0120.009890.008170.0141N/A0.0119 - 0.0229N/A200037440.4350.0120.009940.008200.0141N/A0.0119N/AOrange Juice2006375576.6350.004960.004290.005440.00680N/A0.008 (9)N/A200597441.2350.009220.008550.009710.0127N/A0.002-0.005 (37)N/A200401860350.01060.01490.01320.0178N/AN/AN/APeanut Butter200606620400.010.010.010.0139N/AN/AN/A200007160400.010.0120.0140.0165N/AN/AN/AAverage of 1⁄2 limits of detection (LODs) on an aldicarb basis for non Detects calculated using following formula:Total residue (as aldicarb) = (1⁄2 aldicarb average LOD) + (1/2 aldicarb sulfone average LOD x 0.86) + (1/2 aldicarb sulfoxide average LOD x 0.92).Page 5 of 8Summary of Residue Inputs for Aldicarb Acute Dietary Exposure AnalysesCommodityMax %CT1DataSource2CommodityClassification3Food Forms4Acute RDF5(RDF #)ResidueValue, ppm6ProcessingFactorAcute AR,ppm7Beans (dry)<2.5FTBBaked, boiled, fried, canned:cooked;canned:boiled; cooked:NFSN/A0.008550.050.0000107Coffee Beans1FT/PSBBoiled; cooked:NFSN/A0.00855N/A0.0000855Cottonseed mealN/A0.10.50.0175Cottonseed/35FT/PSBCottonseed oilN/A0.10.10.0035NBUncooked, Cooked (NFS)Grapefruit -Peeled Fruit55PDPPBCanned (NFS)Grapefruit - peel55PDPPBPeel4 detects+ 232 1⁄2LODs + 194zeroesRDF114N/AN/AN/AGrapefruit -Juice55PDP –OrangeJuicePBUncooked, cooked, frozen, canned, juiceconcentrate46 detects+ 772 1⁄2LODs + 669zeroesRDF109N/AN/AN/ANBPeeled fruit: uncooked; cookedLemon<2.5PDP -OrangePBPeeled fruit: canned; Peel: uncooked,baked, boiled, canned, frozen9 detects+ 65 1⁄2LODs + 2898zeroesRDF112N/AN/AN/ALemon - Juice<2.5PDP –OrangeJuicePBcanned, frozen; juice concentrate:frozen, cooked, baked, boiled, canned46 detects+ 0 1⁄2LODs + 1441zeroesRDF110N/AN/AN/ANBPeeled fruitLimes<2.5PDP -OrangePBPeel: baked, boiled;9 detects+ 65 1⁄2LODs + 2898zeroesRDF112N/AN/AN/ALime – Juice<2.5PDP –OrangeJuicePBJuice: uncooked, canned, frozen; Juiceconcentrate: cooked, frozen46 detects+ 0 1⁄2LODs + 1441zeroesRDF110N/AN/AN/ANBUncooked, Cooked (NFS)Orange – Peeledfruit35PDPPBCanned (NFS); Orange Peel: Uncooked;Cooked (NFS); Boiled; Canned (NFS);Frozen (NFS)9 detects+ 1031 1⁄2LODs + 1932zeroesRDF111N/AN/AN/APage 6 of 8Summary of Residue Inputs for Aldicarb Acute Dietary Exposure AnalysesCommodityMax %CT1DataSource2CommodityClassification3Food Forms4ResidueAcute RDF5ProcessingAcute AR,Value, ppm(RDF #)6Factorppm7Orange Juice35PDPPBUncooked, cooked, frozen, canned, juiceconcentrate46 detects+ 474 1⁄2LODs + 967zeroesRDF106N/AN/AN/AHulledN/A0.0047N/A0.00188ButterN/A0.00471.890.00355Peanuts40FT/PSBPeanuts, oilN/A0.00470.180.000338Pecans<2.5FTPBUnbaked, baked, boiled22 detects + 858zeroesRDF104N/AN/AN/AUncooked; Cooked: Baked; Frozen,Baked; Dried (NFS and Boiled)N/A0.006390.30.00192Cooked: Boiled; BakedN/A0.006390.190.00121Potatoes/whitedry and flour15PDP/PSBCooked: FriedN/A0.006390.150.000959NBUncooked; Baked; Cooked (NFS)N/AN/AN/ANBCooked FriedN/A0.62N/ANBCooked: boiledN/A0.5N/APotatoes/ whitepeeled; peelonly; whole;unspecified15PDP/PSPBCanned: Cooked; Canned: Boiled57 detects + 2751⁄2 LOD + 1884zeroesRDF 108N/A0.5N/AFrozen: Cooked; Frozen: Baked;N/APotatoes/ whitepeeled - Frozen15PDP/PSPBFrozen: Fried93 detects + 1391⁄2 LOD + 1312zeroesRDF 113N/A0.62N/ASorghum, grain<2.5FTBBoiled, syrupN/A0.2N/A0.005Soybean flour (defatted, full fat); matureseeds, dry; proteinisolate; sproutedseeds)N/A0.00855N/A0.000214Soybeans<2.5FT/PSBSoybean oilN/A0.008550.30.0000641Sugarcane<2.5FT/PSBSugar-cane, refined; sugar-cane/molassesSugar beets10FT/PSBSugar beet, refined; sugar beet/molassesProcessing studies indicate thatprocessing into sugar andmolasses removes aldicarb residues, so the residues in sugarand molasses are assumed to be zero.NBBoiledN/A0.5N/ANBFriedN/A0.62N/ASweet potato5PDP/PSNBCooked, baked17 detects + 66LODs + 1574zeroesRDF107N/AN/AN/APage 7 of 8Summary of Residue Inputs for Aldicarb Acute Dietary Exposure AnalysesCommodityMax %CT1DataSource2CommodityClassification3Food Forms4ResidueAcute RDF5ProcessingAcute AR,Value, ppm(RDF #)6Factorppm7PBCanned: cooked, boiledN/A0.5N/A1BEAD estimated percent crop treated; Max.= estimated Maximum (for acute exposure).2FT = Field Trials; PS = Processing Study; PDP = USDA Pesticide Data Program (monitoring data).3Refer to HED SOP99.6. NB = Not Blended; PB = Partially Blended; B = Blended.4Food forms shown in the table are taken directly fromthe DEEM software. NFS = not further specified5RDF = Residue Distribution File. Det. = detect; LOD = residues at 1⁄2 LOD; Z = zeroes.6Reported for Blended commodities only, as aldicarb.7For blended commodities, a point estimate was used for the acute analysis, with the %CT and processing factor incorporated intothe AR.Page 8 of 8