[Federal Register Volume 75, Number 224 (Monday, November 22, 2010)]
[Notices]
[Page 71132]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2010-29332]


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 DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[ATSDR-267]


Availability of Draft Toxicological Profiles

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Department of Health and Human Services (DHHS).

ACTION: Notice of availability.

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SUMMARY: This notice announces the availability of the Toxicological 
Profile for Toxaphene (Update) and the Toxicological Profile for 
Trichlorobenzenes for review and comment. We are seeking public 
comments for review and potential inclusion in the profiles. These 
comments can include additional information or reports on studies about 
the health effects of toxaphene and trichlorobenzenes. ATSDR remains 
committed to providing a public comment period for these documents to 
best serve public health and our clients.
    The Comprehensive Environmental Response, Compensation, and 
Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments 
and Reauthorization Act of 1986 (SARA), section 104(i)(3), [42 U.S.C. 
9604(i)(3)], directs the ATSDR administrator to prepare toxicological 
profiles of priority hazardous substances and, as necessary, to revise 
and publish each updated toxicological profile.

DATES: To be considered, comments on these draft toxicological profiles 
must be received not later than February 25, 2011. Comments received 
after the close of the public comment period will be considered at the 
discretion of ATSDR, based upon what is deemed to be in the best 
interest of the general public.

ADDRESSES: Requests for printed copies of the draft toxicological 
profiles should be sent via e-mail to <a href="/cdn-cgi/l/email-protection#e48780878d8a828ba4878087ca838b92"><span class="__cf_email__" data-cfemail="aecdcacdc7c0c8c1eecdcacd80c9c1d8">[email protected]</span></a>, or to Ms. Olga 
Dawkins, Division of Toxicology and Environmental Medicine, Agency for 
Toxic Substances and Disease Registry, Mailstop F-62, 1600 Clifton 
Road, NE., Atlanta, Georgia 30333. Electronic access to these documents 
is also available at: http://www.atsdr.cdc.gov/toxprofiles/index.asp.
    Written comments and other data submitted in response to this 
notice and to the draft toxicological profiles should bear the docket 
control number ATSDR-XXX. Send one copy of all comments and three 
copies of all supporting documents to the attention of Ms. Nickolette 
Roney, Division of Toxicology and Environmental Medicine, Agency for 
Toxic Substances and Disease Registry, Mailstop F-62, 1600 Clifton 
Road, NE., Atlanta, Georgia 30333, by the end of the comment period. 
Electronic comments may be sent via e-mail to: 
<a href="/cdn-cgi/l/email-protection#7703070702151b1e1414181a1a121903043714131459101801"><span class="__cf_email__" data-cfemail="0175717174636d6862626e6c6c646f7572416265622f666e77">[email protected]</span></a>. Please include toxaphene or trichlorobenzenes 
in the subject line of the e-mail. Because all public comments 
regarding ATSDR toxicological profiles are available for public 
inspection, no confidential business information or other confidential 
information should be submitted in response to this notice.

FOR FURTHER INFORMATION CONTACT: Ms. Olga Dawkins, Division of 
Toxicology and Environmental Medicine, Agency for Toxic Substances and 
Disease Registry, Mailstop F-62, 1600 Clifton Road, NE., Atlanta, 
Georgia 30333, telephone (770) 488-3315. Electronic access to this 
document is also available at: http://www.atsdr.cdc.gov/toxprofiles/index.asp.
    Comments and other data submitted in response to this notice and 
the draft toxicological profiles should bear the docket control number 
ATSDR-267.

SUPPLEMENTARY INFORMATION: The Superfund Amendments and Reauthorization 
Act (SARA) (Pub. L. 99-499) amends the Comprehensive Environmental 
Response, Compensation, and Liability Act (CERCLA or Superfund) (42 
U.S.C. 9601 et seq.) by establishing certain responsibilities for ATSDR 
and the U.S. Environmental Protection Agency (U.S. EPA) with regard to 
hazardous substances most commonly found at facilities on the CERCLA 
National Priorities List (NPL). As part of these responsibilities, the 
ATSDR administrator must prepare toxicological profiles for substances 
enumerated on the priority list of hazardous substances. This list 
identifies 275 hazardous substances that, according to ATSDR and U.S. 
EPA, pose the most significant potential threat to human health. The 
availability of the revised priority list of 275 hazardous substances 
was announced in the Federal Register on March 6, 2008 (73 FR 12178). 
In addition, ATSDR has the authority to prepare toxicological profiles 
for substances not found at sites on the NPL, in an effort to ``* * * 
establish and maintain inventory of literature, research, and studies 
on the health effects of toxic substances'' under CERCLA Section 
104(i)(1)(B), to respond to requests for consultation under CERCLA 
Section 104(i)(4), and as otherwise necessary to support the site-
specific response actions conducted by ATSDR.
    Each profile will include an examination, a summary, and an 
interpretation of available toxicological information and 
epidemiological evaluations. This information and these data identify 
the levels of significant human exposure for the substances and for the 
associated health effects. The profiles must also include a 
determination of whether adequate information on the health effects of 
each substance is available or is being developed. If adequate 
information is not available, ATSDR, in cooperation with the National 
Toxicology Program (NTP), is required to ensure the initiation of 
research to determine such health effects.
    Although ATSDR considered key studies for each of the substances 
during the profile development process, this Federal Register notice 
solicits any relevant, additional studies, particularly unpublished 
data and ongoing studies. ATSDR will evaluate such data or studies for 
possible addition to the profiles, now or in the future. All 
toxicological profiles issued as ``Drafts for Public Comment'' 
represent ATSDR's best efforts to provide crucial toxicological 
information on priority hazardous substances.
    The draft toxicological profiles will be made available to the 
public on or about October 17, 2010.

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                  Hazardous substances                        CAS No.
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Toxaphene...............................................       8001-35-2
Trichlorobenzenes *
    1,2,3 Trichlorobenzene..............................         87-61-6
    1,2,4 Trichlorobenzene..............................        120-82-1
    1,3,5 Trichlorobenzene..............................        108-70-3
    Trichlorobenzene....................................      12002-48-1
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* Denotes new profile.


    Dated: November 17, 2010.
Ken Rose,
Director, Office of Policy, Planning and Evaluation, National Center 
for Environmental Health/Agency for Toxic Substances and Disease 
Registry.
[FR Doc. 2010-29332 Filed 11-19-10; 8:45 am]
BILLING CODE 4163-70-P


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