Aldicarb Dietary Risk Assessment Summary 

July 2010 

I. Hazard Assumptions

 Point of Departure based on Human Study; BMDL10 = 0.013 mg/kg/day 

 Intra-species Uncertainty Factor = 10 

 FQPA Safety Factor from new CCA PND11 Study; comparison of RBC cholinesterase 

inhibition for male rats and pups 

 Revised FQPA Safety Factor = 4.8 

 Population Adjusted Dose = 0.00027 mg/kg/day 

II. Food & Water Exposure Assumptions; Usage Assumptions

A. Food Exposure Assumptions 

 Probabilistic Analysis 

 Residues are the combined residues of aldicarb, aldicarb sulfoxide, and aldicarb sulfone 

(calculated as aldicarb) 

 PDP Data 

o Composite Data used in Risk Assessment (RA) (see Table 1 for years and total 

number of samples) 

o Single Serving Data from PDP and Carbamate Task Force were NOT used 

 Orange juice data translated to grapefruit juice, lemon juice, and lime juice 

 Field Trial Data: used for pecans, peanuts, cottonseed, dry beans, sugar beets, soybeans, 

sorghum, sugarcane, pecans, coffee (although some uses were voluntarily cancelled 

during the RED process, scenarios where run since tolerances still exist for them) 

Table 1. Summary of Composite Data Used in Risk Assessment 

Commodity Years of PDP Data Used Total No. of Samples Total No. of Detects 

Potatoes 2000-2002; 2008 2216 57 

Frozen Potatoes (Partially Cooked 

French Fries 

2006-2007 1544 93 

Sweet Potatoes 2003-2004, 2008 1657 17 

Oranges 2000-2001, 2004-2005 2972 9 

Orange Juice 2004-2006 1487 46 

Grapefruit 2005-2006 430 4 

Table 2. Summary of Empirical Processing Factors 

Commodity/Processed Food Form Processing Factor 

Potatoes: dried and cooked food forms 0.3 

Potatoes: fried forms (with and without peel) 0.62 

Potatoes: fried and dried food forms 0.19 

Potatoes: boiled and cooked 0.5 

Potatoes: boiled/cooked and dried food forms 0.15 

Beans, dry 0.05 

Peanut/oil 0.18 

Soybean/oil 0.3 

Cottonseed/oil 0.1 

Sugarcane/sugar beet Residues assumed to be zero 

Page 1 of 8 
B. Water Exposure Assumptions 

 The Agency used PRZM for estimated drinking water concentrations for groundwater 

 Scenario leading to the highest concentrations was Georgia Cotton/Peanut at maximum 

application rates, assuming a 500 ft. well set-back 

 Also conducted analyses using the North Carolina Cotton/Peanut scenario at maximum 

application rates, assuming a 300 ft. well set-back 

 The Agency used groundwater monitoring data to qualitatively validate the estimated 

drinking water concentrations from groundwater identified using PRZM 

C. Usage Assumptions 

 Screening Level Usage Analysis (dated 4/15/10) was used 

 Same percent crop treated assumed for fresh and processed commodities 

III. Risk Assumptions & Characterization

A. Risk Assumptions 

 Refined using Eating Occasion Analysis 

 Human recovery data indicate 2 hour half-life for adults 

 New CCA study did not indicate significant differences in recovery rates between adults 

and pups at lower doses 

 Assessed assuming 1 minute and 120 minute half-lives 

B. Risk Characterization 

 Inclusion of commodities cancelled in the RED does not materially affect the risk. 

 Food exposure is the risk driver for children ages 1-2 and 3-5. 

o Potatoes and citrus are the greatest contributors to food exposure. 

 Water is the most significant contributor to exposure of infants. 

o The use of aldicarb in the southeast U.S. on citrus, peanuts, cotton and soybeans 

leads to the greatest exposure in drinking water. 

 Additional characterization runs, assuming zero residues for all samples included as 1⁄2 

limit of detection for the three analytes, were conducted. 

Table 3. Risk Results – 99.9th Percentile; No Recovery Assumed 

*Bolded values indicate dietary exposures exceeding the level of concern, 100% of the aPAD 

Food Alone Food and Drinking Water/ GA 

Cotton/Peanut Scenario 

Population Subgroup aPAD 

(mg/kg/day) Exposure 

(mg/kg/day)

% aPAD as 

aldicarb

Exposure 

(mg/kg/day)

% aPAD as 

aldicarb

General U.S. Population 0.00031 0.000423 160 0.00176 650 

All Infants (< 1 year old) 0.00031 0.000731 270 0.00428 1600 

Children 1-2 years old 0.00031 0.000866 320 0.00218 810 

Children 3-5 years old 0.00031 0.000737 270 0.00195 720 

Children 6-12 years old 0.00031 0.000459 150 0.00127 470 

Youth 13-19 years old 0.00031 0.000370 140 0.00133 500 

Adults 20-49 years old 0.00031 0.000312 120 0.00138 510 

Page 2 of 8 
Food Alone Food and Drinking Water/ GA 

Cotton/Peanut Scenario aPAD Population Subgroup (mg/kg/day) Exposure % aPAD as Exposure % aPAD as 

(mg/kg/day) aldicarb (mg/kg/day) aldicarb

Adults 50+ years old 0.00031 0.000289 110 0.00103 380 

Females 13-49 years old 0.00031 0.000304 110 0.00134 500 

Table 4. Results of Eating Occasion Risk Assessment at Various Recovery Rates 

Scenario 

1 m Eating 

Occasion % aPAD 

99.91

120 m Eating 

Occasion % aPAD 

99.92

INFANTS 

Food and Water; existing uses GA 500ft 800% 810% 

Food alone existing uses 220% 220% 

Food alone; RED commodities removed 220% 230% 

Food alone; potatoes removed 130% 130% 

Food alone; potatoes and sweet potatoes removed 120% 120% 

Food alone; citrus commodities removed 130% 130% 

Food alone; citrus and potato commodities removed 15% 15% 

Food and water; citrus and potato commodities removed; GA 500 ft 790% 800% 

Food and water; citrus and potato commodities removed; NC 300 ft 250% 250% 

CHILDREN AGES 1-2 

Food and Water; existing uses GA 500ft 430% 440% 

Food alone existing uses 270% 290% 

Food alone; RED commodities removed 280% 290% 

Food alone; potatoes removed 220% 220% 

Food alone; potatoes and sweet potatoes removed 220% 220% 

Food alone; citrus commodities removed 210% 210% 

Food alone; citrus and potato commodities removed 9% 9% 

Food and water; citrus and potato commodities removed; GA 500 ft 300 330 

Food and water; citrus and potato commodities removed; NC 300 ft 

94% 100% 

CHILDREN AGES 3-5 

Food and Water; existing uses GA 500ft 340% 360% 

Food alone existing uses 230% 230% 

Food alone; RED commodities removed 230% 230% 

Food alone; potatoes removed 130% 140% 

Food alone; potatoes and sweet potatoes removed 130% 140% 

Food alone; citrus commodities removed 190% 190% 

Food alone; citrus and potato commodities removed 7% 7% 

Food and water; citrus and potato commodities removed; GA 500 ft 260% 290% 

Food and water; citrus and potato commodities removed; NC 300 ft 84% 92% 1 The Agency historically does not assume a one minute recovery rate in pesticide dietary exposure and risk assessments. 

However, a one minute recovery rate was included in this assessment to demonstrate that the length of the half-life time 

does not substantively affect dietary exposure of aldicarb to infants and children. 2

 120 minute half-life based on human recovery data. 

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Page 4 of 8 

Table 5. Additional Characterization Runs 

*Assuming zero residues for all samples included as 1⁄2 limit of detection for three analytes 

*Bolded values indicate dietary exposures exceeding the level of concern, 100% of the aPAD 

Food Alone

Food alone 

Assuming zeros 

for non Detects for 

Potatoes

Food alone 

Assuming zeros 

for non Detects for 

Potatoes and 

Citrus

Food alone 

Assuming zeros 

for non Detects for 

Citrus; potatoes 

removed

Population Subgroup

NR1 2 hr1 NR1 2 hr1 NR1 2 hr1 NR1 2 hr1 

General U.S. Population 160 -- 150 -- 120 -- 42 -- 

All Infants (< 1 year old) 270 220 210 220 94 90 39 1 

Children 1-2 years old 320 290 310 290 240 230 130 38 

Children 3-5 years old 270 230 270 220 210 180 92 39 

Children 6-12 years old 170 -- 170 -- 140 -- 59 -- 

Youth 13-19 years old 140 -- 120 -- 110 -- 44 -- 

Adults 20-49 years old 120 -- 110 -- 100 -- 31 -- 

Adults 50+ years old 110 -- 110 -- 100 -- 25 -- 

Females 13-49 years old 110 -- 110 -- 94 -- 34 -- 

1

NR = %aPAD directly from DEEMTM. 2 hr. = %aPAD assuming 2 hour 1⁄2 life. 

IV. Commodity Specific (Eaters Only) Analyses 

 Margins of exposure (MOE) greater than 48 would not be of concern 

Table 6. Commodity Specific (Eaters Only) Analysis – Children 1-2

Amount food 

consumed, g/kg 

BW/day 

Max Aldicarb 

Residue, ppm 

(PDP Composite) 

Mg 

aldicarb/ kg 

BW/day 

MOE 

50th percentile of Consumption, Baked potato 3.2 0.49 0.00156 8 

90th percentile of Consumption, Baked potato 11.8 0.49 0.0058 2 

50th percentile of Consumption, Fried Potatoes 2.77 0.051 0.000142 92 

90th percentile of Consumption, Fried Potatoes 5.55 0.051 0.000283 46 

50th percentile of Consumption, Orange Juice 14.1 1 0.0167 0.000236 55 

90th percentile of Consumption, Orange Juice 31.4 0.0167 0.000524 25 

Mg aldicarb/kg BW/day = amount food x max aldicarb residue/1000 

MOE = BMDL10/mg aldicarb day 

MOE should be greater than 48; bolded MOEs indicate MOEs of concern 1 A 15 kg (~33 lb) child drinking 8 oz. (~250 g) would have a consumption of 16.7 g OJ/kg BW. 

Notes: 

Baked Potato Food Form: Potato, tuber w/o peel, cooked, fresh, baked 

Fried Potato Food Form: Potato, tuber, w/o peel, cooked, frozen, fried 

Orange Juice Food Form: Orange, juice, uncooked, fresh, not specified 

No processing factors were applied 
Appendix I. Summary of PDP Data for Aldicarb, Aldicarb Sulfoxide, and Aldicarb Sulfone 

Year 

No. of Samples 

with 

Detectable 

Residues 

Total No. 

of Samples 

Analyzed 

Detect 

Rate 

Max PCT

Average 

Aldicarb 

LOD 

Average 

Sulfoxide 

LOD 

Average 

Sulfone 

LOD 

Average 

Combined 

1⁄2 LODs 

Range of 

Aldicarb 

Detects (No. 

of Detects) 

Range of 

Sulfoxide 

(No. of D

Potatoes 

2008 30 744 4.0 15 0.00357 0.00299 0.00415 0.00494 N/A 0.002-0.02002 12 370 3.2 15 0.0177 0.0344 0.0327 0.0387 N/A 0.045-0.2001 12 733 1.6 15 0.0177 0.0345 0.0350 0.0398 N/A 0.045-02000 3 369 0.8 15 0.0177 0.0527 0.0595 0.0587 N/A 0.045-0

Frozen Potatoes 

2007 32 800 4.0 15 0.00277 0.00284 0.00332 0.00412 N/A 0.002 - 02006 61 744 8.2 15 0.00282 0.00222 0.00343 0.00390 N/A 0.002 - 0

Sweet Potatoes 

2008 1 184 0.5 5 0.00912 0.00853 0.00971 0.0127 N/A 0.042004 8 739 1.1 5 0.00912 0.00259 0.00406 0.00749 N/A 0.0027-02003 8 734 1.1 5 0.0103 0.00897 0.00751 0.0125 N/A 0.0027-0

Grapefruit 

2006 4 216 1.8 55 0.00708 0.005 0.009 0.00971 N/A 0.008 - 02005 0 214 0 55 0.007 0.00699 0.00701 0.00973 N/A N/

Orange 

2005 2 741 0.3 35 0.00910 0.00854 0.00971 0.0126 N/A 0.0304, 2004 0 742 0 35 0.0106 0.0149 0.0156 0.0188 N/A N/2001 4 745 0.5 35 0.012 0.00989 0.00817 0.0141 N/A 0.0119 - 2000 3 744 0.4 35 0.012 0.00994 0.00820 0.0141 N/A 0.01

Orange Juice 

2006 37 557 6.6 35 0.00496 0.00429 0.00544 0.00680 N/A 0.008 2005 9 744 1.2 35 0.00922 0.00855 0.00971 0.0127 N/A 0.002-0.02004 0 186 0 35 0.0106 0.0149 0.0132 0.0178 N/A N/

Peanut Butter 

2006 0 662 0 40 0.01 0.01 0.01 0.0139 N/A N/2000 0 716 0 40 0.01 0.012 0.014 0.0165 N/A N/

Average of 1⁄2 limits of detection (LODs) on an aldicarb basis for non Detects calculated using following formula: 

Total residue (as aldicarb) = (1⁄2 aldicarb average LOD) + (1/2 aldicarb sulfone average LOD x 0.86) + (1/2 aldicarb sulfoxide average L

Page 5 of 8 
 Summary of Residue Inputs for Aldicarb Acute Dietary Exposure Analyses 

Commodity Max % CT1 Data Source2 Commodity Classification 3 Food Forms4 Acute RDF5 (RDF #) Residue Value, ppm 6 

Beans (dry) <2.5 FT B Baked, boiled, fried, canned:cooked; canned:boiled; cooked:NFS N/A 0.00855 Coffee Beans 1 FT/PS B Boiled; cooked:NFS N/A 0.00855 

Cottonseed meal N/A 0.1 

Cottonseed/ 35 FT/PS B Cottonseed oil N/A 0.1 Grapefruit - NB Uncooked, Cooked (NFS) Peeled Fruit 55 PDP PB Canned (NFS) Grapefruit - peel 55 PDP PB Peel 

4 detects+ 232 1⁄2 

LODs + 194 

zeroes 

RDF114 

N/A 

Grapefruit - Juice 55 

PDP – 

Orange 

Juice 

PB Uncooked, cooked, frozen, canned, juice 

concentrate 

46 detects+ 772 1⁄2 

LODs + 669 

zeroes 

RDF109 

N/A 

NB Peeled fruit: uncooked; cooked 

Lemon <2.5 PDP - Orange PB Peeled fruit: canned; Peel: uncooked, baked, boiled, canned, frozen 

9 detects+ 65 1⁄2 

LODs + 2898 

zeroes 

RDF112 

N/A 

Lemon - Juice <2.5 

PDP – 

Orange 

Juice 

PB canned, frozen; juice concentrate: frozen, cooked, baked, boiled, canned 

46 detects+ 0 1⁄2 

LODs + 1441 

zeroes 

RDF110 

N/A 

NB Peeled fruit 

Limes <2.5 PDP - Orange PB Peel: baked, boiled; 

9 detects+ 65 1⁄2 

LODs + 2898 

zeroes 

RDF112 

N/A 

Lime – Juice <2.5 

PDP – 

Orange 

Juice 

PB Juice: uncooked, canned, frozen; Juice concentrate: cooked, frozen 

46 detects+ 0 1⁄2 

LODs + 1441 

zeroes 

RDF110 

N/A 

NB Uncooked, Cooked (NFS) 

Orange – Peeled fruit 35 PDP PB Canned (NFS); Orange Peel: Uncooked; Cooked (NFS); Boiled; Canned (NFS); 

Frozen (NFS) 

9 detects+ 1031 1⁄2 

LODs + 1932 

zeroes 

RDF111 

N/A 

Page 6 of 8 
 Summary of Residue Inputs for Aldicarb Acute Dietary Exposure Analyses 

Commodity Max % CT1 Data Source2 Commodity Classification 3 Food Forms4 Residue Acute RDF5 

Value, ppm (RDF #) 6 

Orange Juice 35 PDP PB Uncooked, cooked, frozen, canned, juice concentrate 

46 detects+ 474 1⁄2 

LODs + 967 

zeroes 

RDF106 

N/A 

Hulled N/A 0.0047 

Peanuts 40 FT/PS B Butter N/A 0.0047 

Peanuts, oil N/A 0.0047 

Pecans <2.5 FT PB Unbaked, baked, boiled 

22 detects + 858 

zeroes 

RDF104 

N/A 

Uncooked; Cooked: Baked; Frozen, Baked; Dried (NFS and Boiled) N/A 0.00639 Cooked: Boiled; Baked N/A 0.00639 

Potatoes/whitedry and flour 15 PDP/PS B 

Cooked: Fried N/A 0.00639 

NB Uncooked; Baked; Cooked (NFS) N/A NB Cooked Fried N/A NB Cooked: boiled N/A 

Potatoes/ whitepeeled; peel only; whole; unspecified 

15 PDP/PS 

PB Canned: Cooked; Canned: Boiled 

57 detects + 275 

1⁄2 LOD + 1884 

zeroes 

RDF 108 N/A 

Frozen: Cooked; Frozen: Baked; 

Potatoes/ whitepeeled - Frozen 15 PDP/PS PB Frozen: Fried 

93 detects + 139 

1⁄2 LOD + 1312 

zeroes 

RDF 113 

N/A 

Sorghum, grain <2.5 FT B Boiled, syrup N/A 0.2 

Soybean flour (defatted, full fat); mature seeds, dry; protein isolate; sprouted seeds) 

N/A 0.00855 

Soybeans <2.5 FT/PS B 

Soybean oil N/A 0.00855 

Sugarcane <2.5 FT/PS B Sugar-cane, refined; sugar- cane/molasses Sugar beets 10 FT/PS B Sugar beet, refined; sugar beet/molasses 

Processing studies indicate that promolasses removes aldicarb residuesand molasses are assumed to be zer

NB Boiled N/A NB Fried N/A 

Sweet potato 5 PDP/PS 

NB Cooked, baked 

17 detects + 66 

LODs + 1574 

zeroes 

RDF107 N/A 

Page 7 of 8 
 Summary of Residue Inputs for Aldicarb Acute Dietary Exposure Analyses 

Commodity Max % CT1 Data Source2 Commodity Classification 3 Food Forms4 Residue Acute RDF5 

Value, ppm (RDF #) 6 

PB Canned: cooked, boiled N/A 

1 BEAD estimated percent crop treated; Max. = estimated Maximum (for acute exposure). 2 FT = Field Trials; PS = Processing Study; PDP = USDA Pesticide Data Program (monitoring data). 3 Refer to HED SOP99.6. NB = Not Blended; PB = Partially Blended; B = Blended. 4 Food forms shown in the table are taken directly from the DEEM software. NFS = not further specified 5 RDF = Residue Distribution File. Det. = detect; LOD = residues at 1⁄2 LOD; Z = zeroes. 6 Reported for Blended commodities only, as aldicarb. 7 For blended commodities, a point estimate was used for the acute analysis, with the %CT and processing factor incorporated into the APage 8 of 8