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**UNITED        STATES**

**SECURITIES        AND EXCHANGE COMMISSION**

**WASHINGTON,        D.C. 20549**

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**FORM        10-KSB/A**

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**Amendment          No. 1**

|  x      | **Annual Report Pursuant                  to Section 13                  or 15(d) of the Securities                  Exchange Act of 1934**     |
|--------------|-------------------------------------------------------------------------------------------------------------------------------------------------|
|         | **For the fiscal year ended                  December                  31, 2006.**                                                              |
|         |                                                                                                                                            |
| ** OR** |
|         |                                                                                                                                            |
|  o      | **Transition Report Pursuant                  to Section                  13 or 15(d) of the Securities Exchange                  Act of 1934** |

**COMMISSION        FILE NUMBER: 33-05384**

**IR        BIOSCIENCES HOLDINGS, INC.**

| **DELAWARE**                                                                                     |   | **13-3301899**                                                               |
|--------------------------------------------------------------------------------------------------|--------|------------------------------------------------------------------------------|
| (State                  or Other Jurisdiction of Incorporation                  or Organization) |   |  (I.R.S.                  Employer Identification                  No.) |
|                                                                                             |   |                                                                         |
| **4021                  N. 75th Street, Suite 201,                  Scottsdale, AZ**             |   |  **85251**                                                              |
|  (Address                  of Principal Executive Offices)                                  |   |  (Zip                  Code)                                            |

**(480)        922-3926**

**NONE**

**COMMON        STOCK, $ 0.001 PAR VALUE PER SHARE**

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**Explanatory        Note**

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**PART      III**

**ITEM        9. DIRECTORS, EXECUTIVE OFFICERS, PROMOTERS AND CONTROL PERSONS**
**AND        CORPORATE GOVERNANCE**
**;        COMPLIANCE WITH SECTION 16(A) OF THE EXCHANGE ACT**

| **Name**                                     |   | **Age** |   | **Position**                                                                                              |
|----------------------------------------------|--------|---------|--------|-----------------------------------------------------------------------------------------------------------|
| Michael                K. Wilhelm            |   | 40      |   | President,                Chief Executive Officer and Director                                            |
| John                N. Fermanis              |   | 53      |   | Chief                Financial Officer                                                                    |
| Hal                N. Siegel, Ph.D.          |   | 52      |   | Sr.                  Director of Product Development and Regulatory Affairs and                  Director |
| Theodore                E. Staahl, M.D.      |   | 62      |   | Director                                                                                                  |
| Robert                J. Hariri, M.D., Ph.D. |   | 48      |   | Director                                                                                                  |

**Michael        K. Wilhelm, President, Chief Executive Officer and Director**

**John        N. Fermanis, Chief Financial Officer**

**Hal        N. Siegel, Ph.D., Sr. Director of Product Development and Regulatory Affairs        and**
**Director**

**Theodore        E. Staahl, M.D., Director**

**Robert        J. Hariri, M.D., Ph.D., Director**

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**FAMILY        RELATIONSHIPS**

**COMMITTEES        **
**OF        THE BOARD OF DIRECTORS**

**CODE        OF ETHICS**

**SECTION        16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE**

**ITEM        10. EXECUTIVE COMPENSATION**

**Summary        Compensation Table**

| **Name                  and****Principal                  Position** | ** ** | **Year** | ** ** | **Salary****($)** | ** ** | **Bonus****($)(1)** | ** ** | **Stock****Awards****($)(2)** | ** ** | **Option****Awards****($)(3)** | ** ** | **All                  Other****Compensation****($)(4)** | ** ** | **Total****($)** |
|----------------------------------------------------------------------|------------|----------|------------|-------------------|------------|---------------------|------------|-------------------------------|------------|--------------------------------|------------|----------------------------------------------------------|------------|------------------|
| Michael                  K. Wilhelm (5)                              |       |     |       |              |       |                |       |                          |       |                           |       |                                                     |       |             |
| President,                  CEO and                                  |       | 2006     |       | $286,317          |       | $41,278             |       | —                       |       | $735,731                       |       | $5,955                                                   |       | $1,069,281       |
| Director                                                             |       | 2005     |       | $275,000          |       | $28,870             |       | —                       |       | $82,912                        |       | —                                                  |       | $386,782         |
|                                                                 |       |     |       |              |       |                |       |                          |       |                           |       |                                                     |       |             |
| John                  N. Fermanis                                    |       | 2006     |       | $98,000           |       | $17,596             |       | —                       |       | —                        |       | —                                                  |       | $115,596         |
| Chief                  Financial Officer                             |       | 2005     |       | $85,000           |       | $4,590              |       | $76,416                       |       | —                        |       | —                                                  |       | $166,006         |
|                                                                 |       |     |       |              |       |                |       |                          |       |                           |       |                                                     |       |             |
| Hal                  N. Siegel                                       |       |     |       |              |       |                |       |                          |       |                           |       |                                                     |       |             |
| Senior                  Director, Product                            |       |     |       |              |       |                |       |                          |       |                           |       |                                                     |       |             |
| Development                  and                                     |       |     |       |              |       |                |       |                          |       |                           |       |                                                     |       |             |
| Regulatory                  Affairs and                              |       | 2006     |       | $42,308           |       | —             |       | —                       |       | $32,071                        |       | $95,574                                                  |       | $169,953         |
| Director                                                             |       | 2005     |       | —           |       | —             |       | —                       |       | —                        |       | $58,285                                                  |       | $58,285          |

| **Named                  Executive Officer**  |   | **Issue                  Date**  |   | **Price**  |   | **Underlying                  Warrants**  |    | **Compensation                  Cost**  |
|----------------------------------------------------|--------|---------------------------------------|--------|-----------------|--------|------------------------------------------------|---------|----------------------------------------------|
| Michael                  K. Wilhelm                |   | July                  14, 2006        |   | $               | 0.250  |                                           | 300,000 |                                         | $ | 41,278 |
|                                               |   | May                  20, 2005         |   | $               | 0.300  |                                           | 80,811  |                                         | $ | 28,870 |
|                                               |   |                                  |   |            |   |                                           |    |                                         |   |   |
| John                  N. Fermanis                  |   | July                  14, 2006        |   | $               | 0.158  |                                           | 62,500  |                                         | $ | 9,596 |
|                                               |   | May                  6, 2005          |   | $               | 0.308  |                                           | 12,500  |                                         | $ | 4,590 |

| **Named                Executive Officer**  |   | **Issue                Date**  |   | **Number                of Shares** |   | **Compensation                Cost**  |
|--------------------------------------------------|--------|-------------------------------------|--------|-------------------------------------|--------|--------------------------------------------|
| John                N. Fermanis                  |   | March                10, 2006       |   | 100,000                             |   | $                                          | 35,000 |
|                                             |   | May                18, 2005         |   | 100,000                             |   | $                                          | 41,416 |

| **Named                  Executive Officer**  |   | **Grant                  Date**  |   | **Price**  |   | **Underlying                  Options**  |                              | **Compensation                  Cost**  |
|----------------------------------------------------|--------|---------------------------------------|--------|-----------------|--------|-----------------------------------------------|-----------------------------------|----------------------------------------------|
| Michael                  K. Wilhelm                |   | September                  13, 2006   |   | $               | 0.220  |                                          |                    3,500,000 |                                         | $ | 469,247 |
|                                               |   | July                  14, 2006        |   | $               | 0.231  |                                          |                    1,896,970 |                                         | $ | 266,484 |
|                                               |   | August                  10, 2005      |   | $               | 0.330  |                                          |                    103,030   |                                         | $ | 27,513 |
|                                               |   | May                  20, 2005         |   | $               | 0.440  |                                          |                    150,000   |                                         | $ | 55,399 |
|                                               |   |                                  |   |            |   |                                          |                              |                                         |   |   |
| Hal                  N. Siegel                     |   | October                  23, 2006     |   | $               | 0.200  |                                          | 200,000                           |                                         | $ | 32,071 |

| **Named                Executive Officer**  |   | **Issue                Date**  |   | **Price**  |   | **Underlying                Warrants**  |   | **Compensation                Cost**  |
|--------------------------------------------------|--------|-------------------------------------|--------|-----------------|--------|----------------------------------------------|--------|--------------------------------------------|
| Hal                N. Siegel                     |   | September                30, 2006   |   | $               | 1.000  |                                         | 2,500  |                                       | $ | 156 |
|                                             |   | June                30, 2006        |   | $               | 1.000  |                                         | 2,500  |                                       | $ | 213 |
|                                             |   | March                31, 2006       |   | $               | 0.125  |                                         | 9,000  |                                       | $ | 2,267 |
|                                             |   | December                31, 2005    |   | $               | 0.125  |                                         | 9,000  |                                       | $ | 2,242 |
|                                             |   | September                30, 2005   |   | $               | 0.125  |                                         | 9,000  |                                       | $ | 3,003 |
|                                             |   | June                30, 2005        |   | $               | 0.125  |                                         | 9,000  |                                       | $ | 2,242 |
|                                             |   | March                31, 2005       |   | $               | 0.125  |                                         | 900    |                                       | $ | 352 |
|                                             |   | March                12, 2005       |   | $               | 0.125  |                                         | 3,000  |                                       | $ | 1,173 |

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*President          and Chief Executive Officer:*

*Chief          Financial Officer:*

*Senior          Director of Product Development and Regulatory Affairs:*

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**Outstanding      Equity Awards at Fiscal Year-End as of December 31, 2006**

|                                                                                                       |   | **Option                  Awards**                                                                       |
|------------------------------------------------------------------------------------------------------------|--------|----------------------------------------------------------------------------------------------------------|
| **Name**                                                                                                   |   | **Number                  of****Securities****Underlying****Unexercised****Options****#****Exercisable** |   | **Number                  of****Securities****Underlying****Unexercised****Options****#****Unexercisable** |   | **Equity                  Incentive Plan Awards: Number of Securities Underlying Unexercised                  Unearned Options****(#)** |   | **Option****Exercise****Price****($)** |   | **Option****Expiration****Date** |
| Michael                  K. Wilhelm                                                                        |   |                                                                                                     | 1,222,416 |   |   | — |   |   | 674,554 |   | $ | 0.231 |   |   | 7/14/2011 |
| President,                  CEO and                                                                        |   |                                                                                                     | 279,299 |   |   | — |   |   | 175,246 |   | $ | 0.220 |   |   | 9/13/2011 |
| Director                                                                                                   |   |                                                                                                     | 1,871,304 |   |   | — |   |   | 1,174,151 |   | $ | 0.220 |   |   | 9/13/2011 |
|                                                                                                       |   |                                                                                                     |   |   |   |   |   |   |   |   |   |   |   |   |   |
| John                  N. Fermanis                                                                          |   |                                                                                                     |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Chief                  Financial Officer                                                                   |   |                                                                                                     | — |   |   | — |   |   | — |   |   | — |   |   | — |
|                                                                                                       |   |                                                                                                     |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Hal                  N. Siegel                                                                             |   |                                                                                                     |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Senior                  Director, Product Development and Regulatory Affairs and                  Director |   |                                                                                                     | 200,000 |   |   | — |   |   | — |   | $ | 0.200 |   |   | 10/23/2011 |

**Director      Compensation**

| **Name**                                 |   |   | **Fees                Earned****or                Paid in****Cash****($**)**** |   |   | **Stock                Awards****($**)**** |   | **Option                Awards****($**)**** |   | **Non-Equity****Incentive****Plan****Compensation****($**)**** |   | **Nonqualified****Deferred****Compensation****Earnings****($**)**** |   | **All                Other****Compensation****($**)**** |   |   | **Total**($**)**                                                              |
|------------------------------------------|--------|--------|--------------------------------------------------------------------------------|--------|--------|--------------------------------------------|--------|---------------------------------------------|--------|----------------------------------------------------------------|--------|---------------------------------------------------------------------|--------|---------------------------------------------------------|--------|--------|-------------------------------------------------------------------------------|
| Mark                L. Witten, Ph.D. (1) |   | $      | 5,000                                                                          |   |   | --                                         |   | --                                          |   | --                                                             |   | --                                                                  |   | --                                                      |   | $      |             5,000 |

| (1) | Mark                  L. Witten, Ph.D. resigned as a member of the Board of Directors                  on May 18,                  2006. On December 16, 2002 we entered into a consulting agreement                  with                  Mark Witten, our chief research scientist and director. The consulting                  agreement was entered into on a month-to-month basis. Under the                  terms of                  this agreement, Dr. Witten agreed to place at our disposal his                  judgment                  and expertise in the area of acute lung injury. In consideration                  for these                  services, we agreed to pay Dr. Witten a non-refundable fee of $5,000                  per                  month. This                  contract was terminated effective February 1,                  2006. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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**LONG          TERM INCENTIVES**

**Stock          Options and Restricted Stock**

**Stock          Incentive Plans**

*2003          Stock Option, Deferred Stock and Restricted Stock Plan*

***Purpose***

***Administration***

***Eligibility***

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***Terms          of Options***

*Purchase          Price*

*Vesting*

*Expiration*

*Transferability*

*Option          Adjustments.*

*Termination,          Modification And Amendment*

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**ITEM          11. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND          RELATED          STOCKHOLDER MATTERS**

**PRINCIPAL          STOCKHOLDERS**

| **Name                    of Beneficial Owner (1)**                                                                                      |   | **Common                    Stock****Beneficially                    Owned(2)** |         | **Percentage                    of****Common                    Stock (3)** |   |
|------------------------------------------------------------------------------------------------------------------------------------------|--------|---------------------------------------------------------------------------------|--------------|-----------------------------------------------------------------------------|--------|
| Michael                    K. Wilhelm                                                                                                    |   |                                                                            | 8,680,657(4  | )                                                                           |   | 7.2 | % |
| John                    N. Fermanis                                                                                                      |   |                                                                            | 180,000(5    | )                                                                           |   | * | % |
| Hal                    N. Siegel, Ph.D.                                                                                                  |   |                                                                            | 249,900(6    | )                                                                           |   | * | % |
| Theodore                    E. Staahl, M.D.                                                                                              |   |                                                                            | 3,489,464(7  | )                                                                           |   | 3.1 | % |
| Robert                    J. Hariri, M.D., Ph.D.                                                                                         |   |                                                                            | —      |                                                                        |   | — | % |
|                                                                                                                                     |   |                                                                            |         |                                                                        |   |   |   |
| Mark                    Witten 1501                    N. Campbell AvenueRoom                    3352Tucson,                    AZ 85724 |   |                                                                            | 8,960,778(8  | )                                                                           |   | 7.8 | % |
|                                                                                                                                     |   |                                                                            |         |                                                                        |   |   |   |
| All                    executive officers and directors as a group (5 persons)                                                           |   |                                                                            | 12,600,021(9 | )                                                                           |   | 10.3 | % |

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**ITEM        12. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR        INDEPENDENCE**

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**ITEM      13. EXHIBITS**

**EXHIBITS**

| **Exhibit                  Number** |   | **Description                  of Exhibit**                                                                                                                                                                                                                                                                                                                                                                              |
|-------------------------------------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 2.1                                 |   | Agreement                  and Plan of Merger dated July 2, 2003 among the Registrant, GPN                  Acquisition Corporation and ImmuneRegen BioSciences, Inc. (incorporated                  by                  reference to exhibit 2 of the Registrant's current report on Form                  8-k                  filed with the Securities and Exchange Commission on July 7,                  2003).    |
|                                |   |                                                                                                                                                                                                                                                                                                                                                                                                                     |
| 3.1                                 |   | Certificate                  of Incorporation filed with the Delaware Secretary of State on                  June 4,                  1985 (incorporated by reference to exhibit 3.1 of the Registrant's                  annual                  report on Form 10-KSB for the year ended December 31, 2001 filed                  with the                  Securities and Exchange Commission on April 16, 2002).     |
|                                |   |                                                                                                                                                                                                                                                                                                                                                                                                                     |
| 3.1(a)                              |   | Certificate                  of Amendment filed with the Delaware Secretary of State on July                  16, 1987                  (incorporated by reference to exhibit 3.1(a) of the Registrant's                  annual                  report on Form 10-KSB for the year ended December 31, 2001 filed                  with the                  Securities and Exchange Commission on April 16, 2002).     |
|                                |   |                                                                                                                                                                                                                                                                                                                                                                                                                     |
| 3.1(b)                              |   | Certificate                  of Amendment filed with the Delaware Secretary of State on February                  3,                  1992 (incorporated by reference to exhibit 3.1(b) of the Registrant's                  annual report on Form 10-KSB for the year ended December 31, 2001                  filed                  with the Securities and Exchange Commission on April 16,                  2002).  |
|                                |   |                                                                                                                                                                                                                                                                                                                                                                                                                     |
| 3.1(c)                              |   | Certificate                  of Amendment filed with the Delaware Secretary of State on November                  23,                  1992 (incorporated by reference to exhibit 3.1(c) of the Registrant's                  annual report on Form 10-KSB for the year ended December 31, 2001                  filed                  with the Securities and Exchange Commission on April 16,                  2002). |
|                                |   |                                                                                                                                                                                                                                                                                                                                                                                                                     |
| 3.1(d)                              |   | Certificate                  of Amendment filed with the Delaware Secretary of State on December                  15,                  1994 (incorporated by reference to exhibit 3.1(d) of the Registrant's                  annual report on Form 10-KSB for the year ended December 31, 2001                  filed                  with the Securities and Exchange Commission on April 16,                  2002). |
|                                |   |                                                                                                                                                                                                                                                                                                                                                                                                                     |
| 3.1(e)                              |   | Certificate                  of Amendment filed with the Delaware Secretary of State on November                  7,                  1995 (incorporated by reference to exhibit 3.1(e) of the Registrant's                  annual report on Form 10-KSB for the year ended December 31, 2001                  filed                  with the Securities and Exchange Commission on April 16,                  2002).  |
|                                |   |                                                                                                                                                                                                                                                                                                                                                                                                                     |
| 3.1(f)                              |   | Certificate                  of Amendment filed with the Delaware Secretary of State on December                  30,                  1996 (incorporated by reference to exhibit 3.1(f) of the Registrant's                  annual report on Form 10-KSB for the year ended December 31, 2001                  filed                  with the Securities and Exchange Commission on April 16,                  2002). |
|                                |   |                                                                                                                                                                                                                                                                                                                                                                                                                     |
| 3.1(g)                              |   | Certificate                  of Amendment filed with the Delaware Secretary of State on November                  8,                  2000 (incorporated by reference to exhibit 3.1(h) of the Registrant's                  annual report on Form 10-KSB for the year ended December 31, 2001                  filed                  with the Securities and Exchange Commission on April 16,                  2002).  |
|                                |   |                                                                                                                                                                                                                                                                                                                                                                                                                     |
| 3.2                                 |   | Amended                  and Restated Bylaws of the Registrant dated as of January 1, 2002                  (incorporated by reference to exhibit 3(b) of the Registrant's                  annual                  report on Form 10-KSB for the year ended December 31, 2001 filed                  with the                  Securities and Exchange Commission on April 16, 2002).                                   |
|                                |   |                                                                                                                                                                                                                                                                                                                                                                                                                     |
| 4.1                                 |   | Specimen                  Common Stock Certificate (incorporated by reference to exhibit                  4.1 of the                  Registrant's registration statement on Form SB-2 (File No. 333-120784)                  filed with the Securities and Exchange Commission on November 24,                  2004).                                                                                                  |

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| **Exhibit                Number** |  | **Description                of Exhibit** |
|-----------------------------------|--|-------------------------------------------|

| 4.2        |   | 2003                    Stock Option, Deferred Stock and Restricted Stock Plan (incorporated                    by                    reference to exhibit 4.1 of the Registrant's registration statement                    on                    Form S-8 (file no. 333-113511) filed with the Securities and                    Exchange                    Commission on March 11, 2004).                                                                                                                                                                    |
|------------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 4.3        |   | Form                    of Warrant by and between the Registrant and each of the Investors                    or                    Creditors, as the case may be, who entered into an Agreement                    filed as                    Exhibit 10.6, 10.7, 10.8 or 10.9 herewith (incorporated by reference                    to                    exhibit 4.1 of the Registrant's current report on Form 8-K filed                    with the                    Securities and Exchange Commission on October 19,                    2004).        |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 4.4        |   | Form                    of Registration Rights (Annex A to Subscription Agreement) by                    and between                    the Registrant and each of the Investors who entered into the                    Agreements                    filed as Exhibits 10.6 and 10.8 herewith (incorporated by reference                    to                    exhibit 4.2 of the Registrant's current report on Form 8-K filed                    with the                    Securities and Exchange Commission on October 19,                    2004).  |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 4.5        |   | Form                    of Anti-Dilution Rights (Annex B to Subscription Agreement) by                    and between                    the Registrant and each of the Investors who entered into the                    Agreements                    filed as Exhibits 10.6 and 10.8 herewith (incorporated by reference                    to                    exhibit 4.3 of the Registrant's current report on Form 8-K filed                    with the                    Securities and Exchange Commission on October 19,                    2004). |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 4.6        |   | Promissory                    Note issued from the Registrant to SBM Certificate Company as                    of April 28,                    2004 (incorporated by reference to exhibit 4.6 of the Registrant's                    registration statement on Form SB-2 (File No. 333-120784) filed                    with the                    Securities and Exchange Commission on November 24,                    2004).                                                                                                                                 |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 4.7        |   | Form                    of Warrant by and between the Registrant and each of the investors                    who                    entered into the Subscription Agreements filed as Exhibits 10.18,                    10.19                    and 10.20 herewith (incorporated by reference from Exhibit 4.1                    to the                    Quarterly Report on Form 10-QSB as filed with the Securities                    and Exchange                    Commission on November 14, 2006).                                                 |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
|  10.1 |   | License                    Agreement dated December 16, 2002 among ImmuneRegen BioSciences,                    Inc., a                    subsidiary of the Registrant, David Harris and Mark Witten (incorporated                    by reference to exhibit 10.4 of the Registrant's registration                    statement on                    Form SB-2 (File No. 333-120784) filed with the Securities and                    Exchange                    Commission on November 24, 2004).                                                            |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 10.1(a)    |   | First                    Amendment to License Agreement dated December 20, 2002 among                    ImmuneRegen                    BioSciences, Inc., a subsidiary of the Registrant, David Harris                    and Mark                    Witten (incorporated by reference to exhibit 10.4(a) of the Registrant's                    registration statement on Form SB-2 (File No. 333-120784) filed                    with the                    Securities and Exchange Commission on November 24,                    2004).                   |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 10.1(b)    |   | Second                    Amendment to License Agreement dated June 26, 2003 among ImmuneRegen                    BioSciences, Inc., a subsidiary of the Registrant, David Harris                    and Mark                    Witten (incorporated by reference to exhibit 10.4(b) of the Registrant's                    registration statement on Form SB-2 (File No. 333-120784) filed                    with the                    Securities and Exchange Commission on November 24,                    2004).                                         |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 10.1(c)    |   | Assignment                    Agreement dated February 23, 2005 between ImmuneRegen BioSciences,                    Inc., a                    subsidiary of the Registrant and Mark Witten (incorporated by                    reference to                    exhibit 10.4(c) of the Registrant's registration statement on                    Form SB-2                    (File No. 333-120784) filed with the Securities and Exchange                    Commission on                    July 20, 2005).                                                   |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 10.1(d)    |   | Assignment                    Agreement dated February 23, 2005 among ImmuneRegen BioSciences,                    Inc., a                    subsidiary of the Registrant, David Harris and Mark Witten (incorporated                    by reference to exhibit 10.4(d) of the Registrant's registration                    statement                    on Form SB-2 (File No. 333-120784) filed with the Securities                    and Exchange                    Commission on July 20, 2005).                                                          |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 10.1(e)    |   | Assignment                    Agreement dated November 7, 2005 between ImmuneRegen BioSciences,                    Inc., a                    subsidiary of the Registrant and Mark Witten (incorporated by                    reference to                    exhibit 10.4(e) of the Registrant's registration statement on                    Form SB-2                    (File No. 333-120784) filed with the Securities and Exchange                    Commission on                    November 16, 2005).                                                |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 10.1(f)    |   | Assignment                    Agreement dated November 7, 2005 between ImmuneRegen BioSciences,                    Inc., a                    subsidiary of the Registrant and Mark Witten (incorporated by                    reference to                    exhibit 10.4(f) of the Registrant's registration statement on                    Form SB-2                    (File No. 333-120784) filed with the Securities and Exchange                    Commission on                    February 22, 2006).                                                |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 10.1(g)    |   | Assignment                    Agreement dated November 7, 2005 between ImmuneRegen BioSciences,                    Inc., a                    subsidiary of the Registrant and Mark Witten (incorporated by                    reference to                    exhibit 10.4(g) of the Registrant's registration statement on                    Form SB-2                    (File No. 333-120784) filed with the Securities and Exchange                    Commission on                    November 16, 2005).                                                |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 10.1(h)    |   | Assignment                    Agreement dated November 7, 2005 between ImmuneRegen BioSciences,                    Inc., a                    subsidiary of the Registrant and Mark Witten (incorporated by                    reference to                    exhibit 10.4(h) of the Registrant's registration statement on                    Form SB-2                    (File No. 333-120784) filed with the Securities and Exchange                    Commission on                    November 16, 2005).                                                |
|       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 10.2       |   | Lease                    Agreement dated July 1, 2004 between ImmuneRegen BioSciences,                    Inc., a                    subsidiary of the Registrant, and The Clayton Companies (incorporated                    by                    reference to exhibit 10.5 of the Registrant's registration statement                    on                    Form SB-2 (File No. 333-120784) filed with the Securities and                    Exchange                    Commission on November 24,                    2004).                              |

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| **Exhibit                Number** |  | **Description                of Exhibit** |
|-----------------------------------|--|-------------------------------------------|

| 10.3   |   | Form                  of Subscription Agreement entered into as of October 13, 2004 between                  the                  Registrant and each of the Investors set forth on the Schedule                  of                  Investors thereto (incorporated by reference to exhibit 10.1 of                  the                  Registrant's current report on Form 8-K filed with the Securities                  and                  Exchange Commission on October 19, 2004).             |
|--------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| 10.4   |   | Form                  of Settlement Agreement entered into as of October 13, 2004 between                  the                  Registrant and each of the Creditors set forth on the Schedule                  of                  Creditors thereto (incorporated by reference to exhibit 10.2 of                  the                  Registrant's current report on Form 8-K filed with the Securities                  and                  Exchange Commission on October 19, 2004).               |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| 10.5   |   | Form                  of Subscription Agreement entered into as of October 26, 2004 between                  the                  Registrant and each of the Investors set forth on the Schedule                  of                  Investors thereto (incorporated by reference to exhibit 10.1 of                  the                  Registrant's current report on Form 8-K filed with the Securities                  and                  Exchange Commission on October 27, 2004).             |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| 10.6   |   | Form                  of Settlement Agreement entered into as of October 26, 2004 between                  the                  Registrant and each of the Creditors set forth on the Schedule                  of                  Creditors thereto (incorporated by reference to exhibit 10.2 of                  the                  Registrant's current report on Form 8-K filed with the Securities                  and                  Exchange Commission on October 27, 2004).               |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| 10.7   |   | Employment                  Agreement dated February 15, 2005 between the Registrant and John                  N.                  Fermanis (incorporated by reference to exhibit 10.10 of the Registrant's                  Amendment No. 1 on Form 10-K/A to its annual report for the year                  ended                  December 31, 2004).                                                                                                                                                 |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| 10.8   |   | Employment                  Agreement dated August 10, 2005 by and between the Registrant and                  Michael                  K. Wilhelm (incorporated by reference to exhibit 10.1 of the Registrant's                  quarterly report on Form 10-QSB for the three months ended September                  30,                  2005).                                                                                                                                                      |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| 10.9   |   | Change                  of Control Agreement dated August 10, 2005 by and between the Registrant                  and Michael K. Wilhelm (incorporated by reference to exhibit 10.2                  of the                  Registrant's quarterly report on Form 10-QSB for the three months                  ended                  September 30, 2005).                                                                                                                                               |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| 10.10  |   | Severance                  Agreement dated November 7, 2005 by and between the Registrant                  and Michael                  K. Wilhelm (incorporated by reference to exhibit 10.3 of the Registrant's                  quarterly report on Form 10-QSB for the three months ended September                  30,                  2005).                                                                                                                                                      |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| 10.11  |   | Authorization                  for Regulatory Contact dated November 7, 2005 between ImmuneRegen                  BioSciences, Inc., a subsidiary of the Registrant, and Synergos,                  Inc.                  (incorporated by reference to exhibit 10.14 of the Registrant's                  registration statement on Form SB-2 (File No. 333-120784) filed                  with the                  Securities and Exchange Commission on February 22,                  2006).          |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| 10.12  |   | Proforma                  invoice/quotation dated November 7, 2005 from Sigma-Aldrich, Inc.                  to                  ImmuneRegen BioSciences, Inc., a subsidiary of the Registrant                  (incorporated by reference to exhibit 10.15 of the Registrant's                  registration statement on Form SB-2 (File No. 333-120784) filed                  with the                  Securities and Exchange Commission on November 16,                  2005).                    |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| 10.13  |   | Letter                  of acceptance dated October 2, 2003, from Huntingdon Life Sciences                  to                  ImmuneRegen BioSciences, Inc., a subsidiary of the Registrant                  (incorporated by reference to exhibit 10.16 of the Registrant's                  registration statement on Form SB-2 (File No. 333-120784) filed                  with the                  Securities and Exchange Commission on February 22,                  2006).                     |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
| 10.14  |   | Price                  Quotation dated June 27, 2003 received by ImmuneRegen BioSciences,                  Inc., a                  subsidiary of the Registrant from AppTec Laboratory Services (incorporated                  by reference to exhibit 10.17 of the Registrant's registration                  statement                  on Form SB-2 (File No. 333-120784) filed with the Securities and                  Exchange                  Commission on February 22,                  2006). |

----

| **Exhibit                Number** |  | **Description                of Exhibit** |
|-----------------------------------|--|-------------------------------------------|

| 10.15  |   | Consulting                    Agreement dated March 15, 2005 between ImmuneRegen BioSciences,                    Inc., a                    subsidiary of the Registrant and Dr. Hal Siegel, Ph.D. (Siegel                    Consultancy) (incorporated by reference to exhibit 10.18 of the                    Registrant's registration statement on Form SB-2 (File No. 333-120784)                    filed with the Securities and Exchange Commission on February                    22,                    2006).    |
|--------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| 10.16  |   | Consulting                    Agreement dated November 3, 2005 between ImmuneRegen BioSciences,                    Inc., a                    subsidiary of the Registrant and Dr. Jack Caravelli, Ph.D (incorporated                    by                    reference to exhibit 10.19 of the Registrant's registration statement                    on                    Form SB-2 (File No. 333-120784) filed with the Securities and                    Exchange                    Commission on February 22, 2006). |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| 10.17  |   | Consulting                    Agreement dated July 29, 2005 between ImmuneRegen BioSciences,                    Inc., a                    subsidiary of the Registrant and Dr. Kelly McQueen, MD, MPH (incorporated                    by reference to exhibit 10.20 of the Registrant's registration                    statement                    on Form SB-2 (File No. 333-120784) filed with the Securities                    and Exchange                    Commission on February 22, 2006).                     |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| 10.18  |   | Form                    of Subscription Agreement entered into as of December 6, 2006                    between the                    Registrant and each of the Investors set forth on the Schedule                    of                    Investors contained therein (incorporated by reference from Exhibit                    10.1                    to the Report on Form 8-K as filed with the Securities and Exchange                    Commission on December 7, 2006).                                       |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| 10.19  |   | Form                    of Subscription Agreement entered into as of October 4, 2006                    between the                    Registrant and each of the Investors set forth on the Schedule                    of                    Investors contained therein. (incorporated by reference from                    Exhibit 10.2                    to the Quarterly Report on Form 10-QSB as filed with the Securities                    and                    Exchange Commission on November 14, 2006).      |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| 10.20  |   | Form                    of Subscription Agreement entered into as of October 26, 2006                    between the                    Registrant and each of the Investors set forth on the Schedule                    of                    Investors contained therein (incorporated by reference from Exhibit                    10.2                    to the Quarterly Report on Form 10-QSB as filed with the Securities                    and                    Exchange Commission on November 14, 2006).      |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| 10.21  |   | Standard                  Form of                  Director Indemnification Agreement.                                                                                                                                                                                                                                                                                                                                                                                                                                       |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| 14.1   |   | Code                    of Ethics, dated April 29, 2005.                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| 21.1   |   | Subsidiaries                    of Registrant (incorporated by reference to exhibit 21.1 of the                    Registrant's registration statement on Form SB-2 (File No. 333-120784)                    filed with the Securities and Exchange Commission on November                    24,                    2004).                                                                                                                                                                                                  |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| 23.1   |   | Consent                    of Russell Bedford Stefanou Mirchandani LLP                                                                                                                                                                                                                                                                                                                                                                                                                                                       |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| 31.1   |   | Certification                    of Chief Executive Officer pursuant to Item 601(b)(31) of Regulation                    S-B,                    as adopted pursuant to Section 302 of the Sarbanes-Oxley Act                    of                    2002.                                                                                                                                                                                                                                                                 |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| 31.2   |   | Certification                    of Chief Financial Officer pursuant to Item 601(b)(31) of Regulation                    S-B,                    as adopted pursuant to Section 302 of the Sarbanes-Oxley Act                    of                    2002.                                                                                                                                                                                                                                                                 |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| 32.1   |   | Certifications                    of Chief Executive Officer pursuant to 18 U.S.C. Section 1350                    as adopted                    pursuant to Section 906 of the Sarbanes-Oxley Act of                    2002.*                                                                                                                                                                                                                                                                                              |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| 32.2   |   | Certifications                    of Chief Financial Officer pursuant to 18 U.S.C. Section 1350                    as adopted                    pursuant to Section 906 of the Sarbanes-Oxley Act of                    2002.*                                                                                                                                                                                                                                                                                              |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |

| * | This                      exhibit shall not be deemed "filed" for purposes of Section                      18 of the                      Securities Exchange Act of 1934 or otherwise subject to the                      liabilities of                      that section, nor shall it be deemed incorporated by reference                      in any                      filing under the Securities Act of 1933 or the Securities Exchange                      Act of                      1934, whether made before or after the date hereof and irrespective                      of any                      general incorporation language in any                      filings. |
|---|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

**ITEM      14. PRINCIPAL ACCOUNTANT FEES AND SERVICES**

|                                   |   | **December                31, 2006 ** |   |   | **December                31, 2005** |
|----------------------------------------|--------|--------------------------------------------|--------|--------|--------------------------------------|
| (i)                Audit Fees          | $      | 58,856                                     |   | $      | 67,000                               |
| (ii)                Audit Related Fees |   | --                                         |   |   | --                                   |
| (iii)                Tax Fees          |   | --                                         |   |   | 10,000                               |
| (iv)                All Other Fees     |   | 4,795                                      |   |   | --                                   |
| Total                fees              | $      | 63,651                                     |   | $      | 77,000                               |

**AUDIT        FEES.**

**TAX        FEES. **

**ALL        OTHER FEES. **

**POLICY        ON AUDIT COMMITTEE PRE-APPROVAL OF AUDIT AND PERMISSIBLE NON-AUDIT SERVICES        OF        INDEPENDENT AUDITORS**

----

**SIGNATURES**

|                                |                                                 |                                                                                                                                                                                                                                                 |
|-------------------------------------|------------------------------------------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                | **IR                BIOSCIENCES HOLDINGS, INC.**     |
|                           |                                            |                                                                                                                                                                                                                                            |
| Date:                April 30, 2007 | By:                                        | /s/                Michael K.                Wilhelm                                 |
|                                | Michael                K. Wilhelm                    |
|                                | President                and Chief Executive Officer |

|  **SIGNATURE**                                                                                                                                                                                                                                                                |   | ** TITLE**                                                                                                 |   | ** DATE**                              |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-----------------------------------------------------------------------------------------------------------------|--------|---------------------------------------------|
|                                                                                                                                                                                                                                                                               |   |                                                                                                            |   |                                        |
| /s/                  Michael K.                  Wilhelm                                  Michael                  K. Wilhelm                                                                      |   | Chief                  Executive Officer, President and Director (Principal Executive                  Officer) |   |  April                  30,  2007 |
|                                                                                                                                                                                                                                                                               |   |                                                                                                            |   |                                        |
| /s/                  John N.                  Fermanis                    John                  N. Fermanis                                                                    |   | Chief                  Financial Officer (Principal Financial and Accounting                  Officer)          |   |  April                  30, 2007       |
|                                                                                                                                                                                                                                                                               |   |                                                                                                            |   |                                        |
| /s/                  Hal N.                  Siegel                                              Hal                  N. Siegel, Ph.D. |   | Director                                                                                                        |   |  April                  30, 2007       |
|                                                                                                                                                                                                                                                                               |   |                                                                                                            |   |                                        |
| /s/                  Theodore E.                  Staahl                                   Theodore                  E. Staahl, M.D.                                                          |   | Director                                                                                                        |   |  April                  30, 2007       |
|                                                                                                                                                                                                                                                                               |   |                                                                                                            |   |                                        |
| /s/                  Robert J.                  Hariri                                           Robert                  J. Hariri, M.D., Ph.D.       |   | Director                                                                                                        |   |  April                  30, 2007       |

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