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                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549


                                FORM 10-K405/A


    Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934


                         Commission File No. 0-15098


                        JONES MEDICAL INDUSTRIES, INC.
            (Exact name of registrant as specified in its charter)


         Delaware
(State or other jurisdiction of                           43-1229854
incorporation or organization)              (I.R.S. Employer Identification No.)


      1945 Craig Road, St. Louis, MO                              63146
    (Address of principal executive offices)                   (Zip Code)


      Registrant's telephone number including area code: (314) 576-6100



         Securities registered pursuant to Section 12(b) of the Act:


Title of Each Class                   Name of Each Exchange on which Registered
-------------------                   -----------------------------------------
       None


         Securities registered pursuant to Section 12(g) of the Act:


                         Common Stock, $.04 par value
                         ----------------------------
                               (Title of class)


                               AMENDMENT NO. 1


        The undersigned Registrant hereby amends the following items, financial
statements, exhibits or other portions of its Annual Report on Form 10-K for
the Fiscal Year Ended December 31, 1995, as set forth on the pages attached
hereto:

    ITEM 14.  EXHIBITS, FINANCIAL STATEMENT SCHEDULES AND REPORTS ON FORM 8-K
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(a)     1.    The consolidated financial statements filed as part of this
              report on Form 10-K are listed on the accompanying Index to 
              Consolidated Financial Statements and Consolidated Financial 
              Statement Schedule on page F-1 (previously filed).

        2.    The consolidated financial statement schedule filed as part of
              this report on Form 10-K is listed on the accompanying Index to
              Consolidated Financial Statements and Consolidated Financial
              Statement Schedule on page F-1 (previously filed).

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3.      Exhibits:

        (3.1)   Restated Certificate of Incorporation of the Company dated June
                21, 1988 (previously filed).

        (3.2)   Certificate of Amendment of the Certificate of Incorporation of
                the Company dated May 14, 1990 (previously filed).
                
        (3.3)   Certificate of Amendment of the Certificate of Incorporation of
                the Company dated May 30, 1991 (previously filed).

        (3.4)   Certificate of Designation of Convertible Preferred Stock,
                Series A as, filed with the Secretary of State of Delaware on 
                May 15, 1991, is incorporated by reference from Form 8-K dated
                May 29, 1991.
                
        (3.5)   Amended By-Laws of the Company as of June 14, 1988 (previously
                filed).

        (3.6)   Amendment to Section 3.02 of By-Laws of the Company as of April
                1, 1992 (previously filed).

        (10.1)  The Company's 1989 Incentive Stock Option Plan (previously
                filed). 

        (10.2)  The Company's Cash or Deferred Profit Sharing Plan and Trust
                amended and restated as of January 1, 1995.     


        (10.3)  Agreement and Plan of Reorganization dated as of December 27,
                1990, as Amended and Restated as of March 15, 1991, between the 
                Company and GenTrac, Inc., is incorporated by reference from 
                Form 8-K dated May 29, 1991.

        (10.4)  Asset Purchase Agreement dated as of February 12, 1993, between
                the Company and Tsumura International, Inc., is incorporated by
                reference from Form 8-K dated February 18, 1993.

        (10.5)  Stock Purchase Agreement dated as of March 22, 1993, among the
                Company and each of the stockholders of Bronson
                Pharmaceuticals, is incorporated by reference from Form 8-K 
                dated April 7, 1993.

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        (10.6) The Company's 1994 Incentive Stock Plan effective June 1, 1994,
               is incorporated by reference from the Company's Proxy Statement
               dated April 21, 1995 for the Annual Meeting of
               Stockholders held May 15, 1995.

        (10.7) The Company's 1994 Formula Stock Option Plan for Non-Management
               Directors effective May 25, 1994, is incorporated by reference
               from the Company's Proxy Statement dated April 21, 1995 for the
               Annual Meeting of Stockholders held May 15, 1995. 

        (10.8) Licensing Agreement dated August 31, 1995 between the Company
               and Eli Lilly & Company is incorporated by reference from Form
               8-K dated September 15, 1995.

        (10.9) Manufacturing Agreement dated August 31, 1995 between the
               Company and Eli Lilly & Company, is incorporated by reference
               from Form 8-K dated September 15, 1996.

        (11.1) Statement re: computation of per share earnings (previously
               filed).

        (21.1) Subsidiaries of the Registrant (previously filed).

        (23.1) Consent of Ernst & Young LLP (previously filed).

        (27.1) Financial Data Schedule (previously filed).

(b)     No reports on Form 8-K were filed by the Company during the last
        quarter of the period covered by this report.

                                  SIGNATURES
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        Pursuant to the requirements of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the Registrant has duly caused this Report to be signed
on its behalf by the undersigned, thereunto duly authorized.
                            
                                       JONES MEDICAL INDUSTRIES, INC.


                                       BY:  /s/ Dennis M. Jones
                                            ------------------------------
                                                Dennis M. Jones, President



Date:  March 18, 1996