Exhibit
21.1

Subsidiaries
of Registrant

|Entity                                                  |  | State of Incorporation |  | Doing Business As(if different from corporate name)
|------------------------------------------------------- |  | ---------------------- |  | ---------------------------------------------------
|Anniston HMA, Inc.                                      |  | Alabama                |  | Stringfellow Memorial Hospital                     
|Biloxi H.M.A., Inc.                                     |  | Mississippi            |  | Biloxi Regional Medical Center                     
|Brandon H.M.A., Inc.                                    |  | Mississippi            |  | Rankin Medical Center                              
|Canton HMA, Inc.                                        |  | Mississippi            | 
|Carlisle HMA, Inc.                                      |  | Pennsylvania           |  | Carlisle Regional Medical Center                   
|Citrus HMA, Inc.                                        |  | Florida                | 
|Clarksdale H.M.A., Inc.                                 |  | Mississippi            |  | Northwest Mississippi Regional Medical Center      
|Coffee Hospital Management                              |  | Tennessee              | 
|Associates, Inc. (1)                                    | 
|Collier HMA, Inc.                                       |  | Florida                |  | Collier Regional Medical Center                    
|Durant H.M.A., Inc.                                     |  | Oklahoma               |  | Medical Center of Southeastern Oklahoma            
|Durant HMA Surgical Center, Inc. (5)                    |  | Oklahoma               |  |                                                    
|Gaffney H.M.A., Inc.                                    |  | South Carolina         |  | Upstate Carolina Medical Center                    
|Green Clinic, Inc.                                      |  | Florida                |  |                                                    
|Haines City H.M.A., Inc.                                |  | Florida                |  | Heart of Florida Regional Medical Center           
|Hamlet H.M.A., Inc.                                     |  | North Carolina         |  | SandHills Regional Medical Center                  
|Hartsville H.M.A., Inc.                                 |  | South Carolina         |  | Carolina Pines Regional Medical Center             
|Hartsville HMA Physician Management, Inc.               |  | South Carolina         |  | The Medical Group                                  
|Health Management Associates of West Virginia, Inc. (1) |  | West Virginia          |  | Williamson Memorial Hospital                       
|Health Management Associates, Inc.                      |  | Kentucky               |  |                                                    
|Health Management Investments, Inc.                     |  | Delaware               | 
|Hernando H.M.A., Inc.                                   |  | Florida                |  | Brooksville Regional Hospital                      
|                                                        |  |                        |  | Spring Hill Regional Hospital                      
|HMA Fentress County General Hospital, Inc.              |  | Tennessee              |  | Jamestown Regional Medical Center                  
|HMA Foundation, Inc.                                    |  | Florida                |  |                                                    
|HMA Mesquite Hospital, Inc.                             |  | Texas                  |  | Medical Center of Mesquite                         
|HMA Santa Rosa Medical Center, Inc.                     |  | California             |  | Santa Rosa Medical Center                          
|Hospital Management Associates, Inc.                    |  | Kentucky               | 
|Insurance Company of the Southeast, Ltd.                |  | Cayman Islands, BWI    |  |                                                    
|Jackson HMA North Medical Office Building, Inc.         |  | Mississippi            | 
|Jackson HMA, Inc.                                       |  | Mississippi            |  | Central Mississippi Medical Center                 
|Kentucky HMA Physician Management, Inc.                 |  | Kentucky               | 
|Kennett HMA, Inc.                                       |  | Missouri               |  |                                                    
|Key West HMA Physician Management, Inc.                 |  | Florida                | 
|Key West HMA, Inc.                                      |  | Florida                |  | Lower Keys Medical Center                          
|Keystone HMA Property Management, Inc.                  |  | Pennsylvania           | 
|Lake Norman HMA Surgical Center, Inc.                   |  | North Carolina         |  |                                                    
|Lancaster HMA, Inc.                                     |  | Pennsylvania           |  | Community Hospital of Lancaster                    
|Lancaster HMA Physician Management, Inc.                |  | Pennsylvania           |  | Central Penn Medical Group                         
|Lebanon HMA, Inc.                                       |  | Tennessee              | 
|Lehigh HMA, Inc.                                        |  | Florida                |  | Lehigh Regional Medical Center                     

67

---

|Entity                                           |  | State of Incorporation |  | Doing Business As(if different from corporate name)
|------------------------------------------------ |  | ---------------------- |  | ---------------------------------------------------
|Little Rock H.M.A., Inc.                         |  | Arkansas               |  | Southwest Regional Medical Center                  
|Lone Star HMA, L.P.                              |  | Delaware               |  | Mesquite Community Hospital                        
|Louisburg H.M.A., Inc.                           |  | North Carolina         |  | Franklin Regional Medical Center                   
|Madison HMA, Inc.                                |  | Mississippi            |  | Madison County Medical Center                      
|Marathon H.M.A., Inc.                            |  | Florida                |  | Fishermen's Hospital                               
|Meridian H.M.A. Nursing Home, Inc.               |  | Mississippi            | 
|Meridian H.M.A., Inc.                            |  | Mississippi            |  | Riley Memorial Hospital                            
|Meridian HMA Clinic Management, Inc.             |  | Mississippi            | 
|Mesquite HMA General, LLC                        |  | Delaware               |  |                                                    
|Mesquite HMA Limited, LLC                        |  | Delaware               | 
|Midwest City H.M.A., Inc.                        |  | Oklahoma               |  | Midwest Regional Medical Center                    
|Monroe HMA, Inc.                                 |  | Georgia                |  | Walton Regional Medical Center                     
|Mooresville HMA Physician Management, Inc.       |  | North Carolina         |  | Primary Care Associates                            
|Mooresville Hospital Management Associates, Inc. |  | North Carolina         |  | Lake Norman Regional Medical Center                
|Natchez Community Hospital, Inc.                 |  | Mississippi            |  | Natchez Community Hospital                         
|Orlando H.M.A., Inc.                             |  | Florida                |  | University Behavioral Center                       
|Paintsville Hospital Company (1)                 |  | Kentucky               |  | Paul B. Hall Regional Medical Center               
|Pasco HMA, Inc.                                  |  | Florida                |  | Pasco Regional Medical Center                      
|PBEC HMA, Inc.                                   |  | Florida                |  | Pelican Bay Executive Center                       
|Pennington Gap HMA, Inc.                         |  | Virginia               |  | Lee Regional Medical Center                        
|Personal Home Health Care, Inc.(2)               |  | Tennessee              |  |                                                    
|Polk HMA, Inc.                                   |  | Florida                | 
|Poplar Bluff HMA, Inc.                           |  | Missouri               |  |                                                    
|Punta Gorda HMA, Inc.                            |  | Florida                |  | Charlotte Regional Medical Center                  
|Regional Cardiology Center, LLC (3)              |  | Mississippi            |  |                                                    
|River Oaks Hospital, Inc                         |  | Mississippi            |  | River Oaks Health System                           
|River Oaks Management Company (4)                |  | Mississippi            |  | Preferred Medical Network                          
|River Oaks Medical Office Building, Inc. (4)     |  | Mississippi            | 
|Riverview Regional Medical Center, Inc.          |  | Alabama                |  | Riverview Regional Medical Center                  
|ROH, Inc. (4)                                    |  | Mississippi            |  | Woman's Hospital at River Oaks                     
|Rose City HMA, Inc.                              |  | Pennsylvania           |  | Lancaster Regional Medical Center                  
|Sebastian Hospital, Inc.                         |  | Florida                |  | Sebastian River Medical Center                     
|Sebring Hospital Management Associates, Inc.     |  | Florida                |  | Highlands Regional Medical Center                  
|Statesboro H.M.A., Inc.                          |  | Georgia                |  | East Georgia Regional Medical Center               
|Statesville HMA, Inc.                            |  | North Carolina         |  | Davis Regional Medical Center                      
|Tequesta H.M.A., Inc.                            |  | Florida                |  | SandyPines                                         
|The Surgery Center at Durant, LLC (6)            |  | Oklahoma               |  | The Surgery Center at Durant                       
|Topeka H.M.A., Inc.                              |  | Kansas                 | 
|Tullahoma HMA, Inc.                              |  | Tennessee              |  |                                                    
|Van Buren H.M.A., Inc.                           |  | Arkansas               |  | Crawford Memorial Hospital                         
|Yakima HMA, Inc                                  |  | Washington             |  | Yakima Regional Medical & Heart Center             
|Yakima HMA Physician Management Corp.            |  | Washington             | 

|(1) |  | Subsidiary
of Health Management Associates, Inc. (Kentucky)
|--- |  | -----------------------------------------------------------

|(2) |  | Subsidiary
of HMA Fentress County General Hospital, Inc.
|--- |  | --------------------------------------------------------

|(3) |  | Subsidiary
of Biloxi H.M.A., Inc.
|--- |  | ---------------------------------

|(4) |  | Subsidiary
of River Oaks Hospital, Inc.
|--- |  | ---------------------------------------

|(5) |  | Subsidiary
of Durant H.M.A., Inc.
|--- |  | ---------------------------------

|(6) |  | Subsidiary
of Durant HMA Surgical Center, Inc.
|--- |  | ----------------------------------------------

68