Related ca s e s : H ealth related cases : Ecotox related cases : C on c e1 ·n l evel s: T y pe of C oncern: Le v el of C oncern: Health 2 Per s i s tence 1 

### SAT Report PMN N umber : P-15-060 7 SAT Date : 7/24/ 2014 Pr int D ate: 11 / 3 / 2015

E co C omments

2 Yes

Bioac c um 1 Toxicity 2 C omment s PMN 1 1 1 

# -

E xpo s ure Bas ed Review: Health: No E cotox: Yes Route s of expo s ure: Keyword s : Health: De1mal D rink in g Water Inh al ati on Ec otox: A ll r eleases to water Fate: ; Ke y word s : IRR

- E , MM, L ; LIVER ; KI D NE Y ; D EVE L ; B LOOD ; H EAR T ; SENS ; UNC E R T ONCO; AQUATOX

- A , C S ummary of A ss e ss ment: Fate: FATE: Liq u id l og Kow = 4.84 (M) S = Reacts I 10 m g/L at 25 

## oc (M I M) H yd r olysis h al f -li fe = hr- da VP = 3
. 0E

- 2 to n at 25 

## oc (M) BP = Dec
. 110 

## oc (M) H = 1.04E-3 (E )l og Koc = 4
. 93 (E) l og Fish BCF = 2.86 (E) l og Fish BAF = 2
. 52 (E) POTW removal (%) = 90

- 99 v ia h yd r olysis , then 90

- 99 v ia so rp t ion Time for comp l ete ultimate aer obic biodeg = H yd Pdt**~** mo S01pt i on to soils/ sediment s = H yd Pdt st r o n g Volati li zation half-life from a standard river = 3 hr s Volati li zation half-life from a standard lake = 7 da Atmospheri c Oxidation H alf-lif e = 29 hr via OH radical PB T Potent ial : PMN P1B1 ; H yd Pdt P1B1 *CEB F ATE: Migra t ion to ground water = H yd Pdt n egl Health: Health Summary: Abs01ption i s poor with r eaction all routes, based on physical/chemical propetiies
. The PMN substance is a strong oxidi zer . There are co n ce m s for initation to t he eye , mucous membranes , and hmg al so concem for heati, liver, kidney , b l ood , and developmental toxici t ies, se n sit iz atio n , and lmcet ia in oncogeni city
. based on analogs and subm i t

ted t est data
. Test Data: PMN : (

- )Salmone lla with and w i t h out acti vati on;(

- ) E
. coli with and without activation; (

- ) in 4h and 24h mouse lymphoma assays ; n ot co n os i ve to human skin in v i t ro ; ra t oral OECD 422 LOEL = 50 mglkg, effects to the heat i (mal e) and li ver (femal e) at 50 mg/kg , also effects to the blood, kidney and spleen at higher doses, NOEL (rep r o) = 150 mg/kg rat 90-day oral NOEL = 50 w i t h effects to the thyroid, liver, and b l ood at oral developmental NOEL = 100 mg/kg ; rat dietaty 2-generation reproductive toxicity NOEL = 10000 ppm (highes t dose tested)

- Sa lmo nell a assay negative with and w i t h out acti vati on ; E
. coli r everse mu tation assay ne gative w i t h and without activation; Nega t ive for c hromosome abena t ions in C HL ce ll s ; Mouse micronucleus assay via the oral r oute negative; Mild to moderate eye initant in rabbits; Ra t repeat dose (42D) o ral (gavage) toxicity test : no NOEL established , bu t with adverse effects to t he li ver, kidney , and blood at 1000 mg/kg ; Ra t acute ( 15D ) o ral (gavage) toxicity LD50 > 2000 mg/kg ; Ra t acute ( 15D ) dennal toxicity LD 50 > 2000 mg/kg ; Demal ini tant in rabb i ts ; Moderate de mal initant in male rabbit s ; Detmal sensitizer in guinea pigs at 50% a .i
. c h allen ge so lu t ion ; Not a dennal se n sit izer in gu ine a pigs at 10% a.i. Subm i t

ted w i t h 8e) 19260 Rabbit oral developmental study: developmental e f fects includin g r educed fetal weights and delayed ossificatio n s see n at 300 mg/kgEcotox: Te s t End Predicted Mea s ured C omments

fi s h chronic > 0
. 6 value daphnid chronic 1.4 1.5 v alue algal chronic 0 .56 1
. 9/0.56 v alue 3-h EC50 Chronic

Value Ecotox Value s C omments : Profile is based o n SARs n ea r est analog f o reco t ox c h em ical class:

- MW26 4 ; liqu id wi t h unknow n m p( P ) ; S = 10 at (P ); log Kow 

### = 4
. 8 (EPI ) ; p H 7 ; h a r dness < 180
. 0 m g/L as CaC03 ; effective co n cent r ati on s based on 100% ac ti ve ingredie n ts and m ean m easured co n ce n t ratio n s ; and TOC < 2.0 m g/L ;

s u bmitted two eco t oxi city s tudi es on P-1 5

- 0607 (r evi ewed be l ow)
. • ac u t e bas e set · · t es t s · · · an d · ·

< HU C UH;;:, were co n d u c t ed u s m g a co nt a m mg 53
. 9% min er a l sp ir it s as d i lu ents (co mmercial f o n nu l ati on ). M iner a l sp ir it s r efer s to a r ange of p eu·o l eum solven ts co n s i st in g la r gely of sat ur ated h ydr ocarbo n s , in cludin g bo t h st r a

i gh t
- c h ain an d b r anc h ed pa r a f f

ms, and cyclopa r a f f

ms, w hi c h m ay h ave alky l s i de c h a in s. There a r e co n ce m s w i t h min eral spir i ts as dilue n ts s in ce min eral s p irits a r e docume nted to p r esent tox icity an d p otentia ll y r educe b i oava i la b i lity of

- T h e studi es co m p l et ed in 1 997 wer e co n d u c t ed w i t h ace t one as t h e**llll~ '**  ..**'** mea s ured and pur i ty conected te s t re s ult s from both P-15-0607 and was t h e mo st se n s itive f o r the acute and c hro n ic 1 s 1mp 01tant to note tha t r es ul ts and a r e read ac r oss to P-15-0607
. S in ce bioma ss is a more**se iti** **~** growth r ate, EPA cal c ul ated an EC50 and EC10 for the 72 -h our al gae s tudy- Based o n the exper imental 72 -h our algae E C50 for biomass of 1.12 mg a .i ./L ( 1120 11 g a.i ./L) , a n d the**~** assessment factor of 4 , the ac u te co n cent r ati on of co n ce m**~-0607** -i s 281 11g a.i ./L
. The c hronic value (C h V) fo r P-1 5

- 0607

- i s t h e**EC1 in** **g** a Ch V of0.56 mg a .i ./L (560 11 g a.i ./L). The c hronic CoC for P-15-0607- then de ri ved by di v iding t h e est im ated Ch V b y an assessme nt factor of 1 0 y ielding a c hro ni c CoC of 56 11g a.i ./L
. Acute COC: 28 1 ppb Chroni c COC: 56 ppb Ecotoxi city R eviewer : Date : 7/ 28 / 2015

Ecotox Factors Comments:

SA T Chair: Fate as s e ss or: Comments

Health as s e ss or: