**EXHIBIT        31.1**

**CERTIFICATION        OF CEO PURSUANT TO**

**SECURITIES        EXCHANGE ACT RULES 13A-14 AND 15D-14**

**AS        ADOPTED PURSUANT TO**

**SECTION        302 OF THE SARBANES-OXLEY ACT OF 2002**

| 2.                  Based on my knowledge, this annual report does not contain any                  untrue                  statement of a material fact or omit to state a material fact necessary                  to                  make the statements made, in light of the circumstances under which                  such                  statements were made, not misleading with respect to the period                  covered by                  this annual report; |
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| 3.                  Based on my knowledge, the financial statements, and other financial                  information included in this annual report, fairly present in all                  material                  respects the financial condition, results of operations and cash                  flows of                  the registrant as of, and for, the periods presented in this annual                  report; |
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| (a)                  Designed such disclosure controls and procedures or caused such                  disclosure                  controls and procedures to be designed under our supervision, to                  ensure                  that material information relating to the registrant, including                  its                  consolidated subsidiaries, is made known to us by others within                  those                  entities, particularly during the period in which this annual report                  is                  being prepared; |
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| (b)                  Evaluated the effectiveness of the registrant's disclosure controls                  and                  procedures and presented in this annual report our conclusions                  about the                  effectiveness of the disclosure controls and procedures, as of                  the end of                  the period covered by this report based on such evaluation;                  and |
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| (c)                  Disclosed in this report any change in the registrant's internal                  control                  over financial reporting that occurred during the registrant's                  most recent                  fiscal quarter (the registrant's fourth fiscal quarter in the case                  of an                  annual report) that has materially affected, or is reasonably likely                  to                  materially affect, the registrant's internal control over financial                  reporting; and |
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| 5.                  The registrant's other certifying officer and I have disclosed,                  based on                  our most recent evaluation of internal control over financial reporting,                  to the registrant's auditors and the audit committee of the registrant's                  board of directors (or persons performing the equivalent                  functions): |
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| (a)                  All significant deficiencies and material weaknesses in the design                  or                  operation of internal control over financial reporting which are                  reasonably likely to adversely affect the registrant's ability                  to record,                  process, summarize and report financial information;                  and |
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| (b)                  Any fraud, whether or not material, that involves management or                  other                  employees who have a significant role in the registrant's internal                  control                  over financial reporting. |
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|                                         | **IR                  BIOSCIENCES HOLDINGS, INC.**     |
|                                    |                                              |                            |
| Date: October                  10, 2007 | By:                                          | ____________________________________ |
|                                         | Michael                  K. Wilhelm                    |
|                                         | President                  and Chief Executive Officer |

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