<PAGE>

                                                                  EXHIBIT 10.24c

                          SECOND AMENDMENT TO SUBLEASE

THIS SECOND AMENDMENT TO SUBLEASE ("Second Amendment") is made as of June 1,
2004 by and between Sorrento Montana, LP., a California Limited Partnership
("Landlord") and Integra NeuroSciences CA Corporation, a Delaware Corporation
("Tenant"), with reference to the following facts and circumstances:

            A. Landlord and Camino NeuroCare, Inc. entered into a Sublease dated
            July 1, 2001 ("Sublease") for approximately 16,205 square feet of
            premises commonly known as Suites #706 through #714 and Suite #716,
            5965 Pacific Center Boulevard, San Diego, California 92121
            ("Premises").

            B. Landlord and Tenant subsequently amended and supplemented the
            Sublease through First Amendment to Sublease dated July 1, 2003
            which in part substituted Integra Neurosciences CA Corporation for
            Camino NeuroCare, Inc. as Tenant and extended the term of the
            Sublease two additional years through June 30, 2005.

Landlord and Tenant desire to modify, amend and supplement the Sublease through
this Second Amendment as follows:

            1. Paragraph 1.4 ("PREMISES") is hereby amended to add the
            approximately 1,180 square foot Suite #717, 5965 Pacific Center
            Boulevard, San Diego, California 92121 to Tenant's Premises in an
            "as is" condition effective June 1, 2004 resulting in Premises of
            approximately 17,385 square feet.

            2. Paragraph 1.8 ("INITIAL SECURITY DEPOSIT") is hereby amended to
            provide for Tenant's Security Deposit to be Increased by One
            Thousand One Hundred Twenty-One and No/100 Dollars ($1,121.00),
            resulting in a Security Deposit of Sixteen Thousand Five Hundred
            Fifteen and 75/100 Dollars ($16,515.75).

            3. Paragraph 1.9.1 ("BASE RENT") is amended to provide for payment
            by Tenant of Base Rent of Sixteen Thousand Five Hundred Fifteen and
            75/100 Dollars ($16,515.75) per month effective June 1, 2004.

            4. Paragraph 17.0 ("OPTION TO RETURN PREMISES") is hereby deleted in
            its entirety.

                        Except as specifically provided in this Second
Amendment, all of the terms, conditions and definitions set forth in the
Sublease shall remain unchanged and in full force and effect. In the event of
any conflict between this Second Amendment and the Sublease, the terms of this
Second Amendment shall prevail.

                                     Page 1
<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Second Amendment To
Sublease effective the day and year first written above:

LANDLORD:                                                TENANT:

SORRENTO MONTANA, L.P.                           INTEGRA NEUROSCIENCES CA
                                                 CORPORATION
                                                 A Delaware Corporation

A California Limited Partnership
By:  Sorrento Commercial Properties, Inc.        By: /s/ Stuart M. Essig
A California Corporation doing business as       -----------------------
Sorrento Management Company                      Title: President and CEO

                                                 Date: 5/11/04
By: /s/ Roger W. Hillbrook
    -------------------------------
    Roger W. Hillbrook
    Vice President/Corporate Broker

Date: 5/12/04

                                     Page 2