Related cases: 

Health related cases: 

Ecotox related cases: 

Conce1·n levels: 

Type of Concern: 

Level of Concern: 

Health 

2 

Persistence 

1 

SAT Report 

PMN Number: P-15-0607 

SAT Date: 7/24/2014 

Print Date: 11/3/2015 

Eco Comments 

2 

Yes 

Bioaccum 

1 

Toxicity 

2 

Comments 

PMN 

1 1 1 -

Exposure Based Review: 

Health: No 

Ecotox: Yes 

Routes of exposure: 

Keywords: 

Health: De1mal Drinking Water Inhalation 

Ecotox: All releases to water 

Fate: ; 

Keywords: IRR-E,MM,L; LIVER; KIDNEY; DEVEL; BLOOD; HEART; SENS; 

UNCERT ONCO; AQUATOX-A,C 

Summary of Assessment: 

Fate: 

FATE: 

Liquid 

log Kow = 4.84 (M) 

S = Reacts I 10 mg/L at 25 oc (M I M) 

Hydrolysis half-life = hr-da 

VP = 3.0E-2 ton at 25 oc (M) 

BP = Dec. 110 oc (M) 

H = 1.04E-3 (E) 
log Koc = 4.93 (E) 

log Fish BCF = 2.86 (E) 

log Fish BAF = 2.52 (E) 

POTW removal (%) = 90-99 via hydrolysis, then 90-99 via sorption 

Time for complete ultimate aerobic biodeg = Hyd Pdt ~ mo 

S01ption to soils/sediments = Hyd Pdt strong 

Volatilization half-life from a standard river = 3 hrs 

Volatilization half-life from a standard lake = 7 da 

Atmospheric Oxidation Half-life = 29 hr via OH radical 

PBT Potential: PMN P1B1; Hyd Pdt P1B1 

*CEB FATE: Migration to ground water = Hyd Pdt negl 

Health: 

Health Summary: Abs01ption is poor with reaction all routes, based on 

physical/chemical propetiies. The PMN substance is a strong oxidizer. There are concems for 

initation to the eye, mucous membranes, and hmg also concem for heati, liver, kidney, blood, 

and developmental toxicities, sensitization, and lmcetiain oncogenicity. based on analogs and 

submitted test data. 

Test Data: PMN: (-)Salmonella with and without activation;(-) E. 

coli with and without activation; (-) in 4h and 24h mouse lymphoma assays; not con osive to 

human skin in vitro; rat oral OECD 422 LOEL = 50 mglkg, effects to the heati (male) and liver 

(female) at 50 mg/kg, also effects to the blood, kidney and spleen at higher doses, NOEL (repro) 

= 150 mg/kg 

rat 90-day oral NOEL = 50 with effects to the thyroid, liver, and blood 

at oral developmental NOEL = 100 mg/kg; rat dietaty 2-generation 

reproductive toxicity NOEL = 10000 ppm (highest dose tested) 

- Salmonella assay negative with and without activation; 

E. coli reverse mutation assay negative with and without activation; 

Negative for chromosome abenations in CHL cells; 

Mouse micronucleus assay via the oral route negative; 

Mild to moderate eye initant in rabbits; 

Rat repeat dose (42D) oral (gavage) toxicity test: no NOEL established, but with adverse effects 

to the liver, kidney, and blood at 1000 mg/kg; 

Rat acute (15D) oral (gavage) toxicity LD50 > 2000 mg/kg; 

Rat acute (15D) dennal toxicity LD50 > 2000 mg/kg; 

Demal initant in rabbits; 

Moderate demal initant in male rabbits; 

Detmal sensitizer in guinea pigs at 50% a.i. challenge solution; 

Not a dennal sensitizer in guinea pigs at 10% a.i. 

Submitted with 8e) 19260 

Rabbit oral developmental study: developmental effects including reduced fetal weights and 

delayed ossifications seen at 300 mg/kg 
Ecotox: 

Test End Predicted Measured Comments 

fish chronic >0.6 

value 

daphnid chronic 1.4 1.5 

value 

algal chronic 0.56 1.9/0.56 

value 

3-h EC50 

Chronic 

Value 

Ecotox Values Comments: Profile is based on SARs nearest analog forecotox chemical class: - MW264; liquid with unknown mp(P); S = 10 

at (P); log Kow = 4.8 (EPI); pH 7; hardness <180.0 mg/L as CaC03; effective 

concentrations based on 100% active ingredients and mean measured concentrations; and TOC 

<2.0 mg/L; 

submitted two ecotoxicity studies on P-15-0607 (reviewed below) . • 

acute base set · · tests · · · and · · 

<HUCUH;;:, were 

conducted usmg a contammg 53.9% mineral spirits as 

diluents (commercial fonnulation). Mineral spirits refers to a range of peu·oleum solvents 

consisting largely of saturated hydrocarbons, including both straight-chain and branched 

paraffms, and cycloparaffms, which may have alkyl side chains. There are concems with mineral 

spirits as diluents since mineral spirits are documented to present toxicity and potentially reduce 

bioavailability of- The studies completed in 1997 were conducted with acetone as the 
llll~' .. ' measured and purity conected test results from both P-15-0607 and 

was the most sensitive for the acute and chronic 

1s 1mp01tant to note that results and are read across to 

P-15-0607. Since biomass is a more se iti ~ growth rate, EPA calculated an 

EC50 and EC10 for the 72-hour algae study-Based on the experimental 72-hour 

algae EC50 for biomass of 1.12 mg a.i./L (1120 11g a.i./L ), and the ~ assessment 

factor of 4, the acute concentration of concem ~-0607 -is 281 11g 

a.i./L. The chronic value (ChV) for P-1 5-0607- is the EC1 ing 

a ChV of0.56 mg a.i./L (560 11g a.i./L). The chronic CoC for P-15-0607-then 

derived by dividing the estimated Ch V by an assessment factor of 10 yielding a chronic CoC of 

56 11g a.i./L. 

Acute COC: 281 ppb 

Chronic COC: 56 ppb 

Ecotoxicity Reviewer: 

Date: 7/28/2015 

Ecotox Factors Comments: 

SAT Chair: 

Fate assessor: 

Comments 

Health assessor: