Initial to indicate certification as to information on this page (full text of certification is on page one). Date INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary. 2. Case # and Name 3. Date and Type of DCI and Number

4. EPA Product Registration 5. I wish to cancel this product registration voluntarily 6. Generic Data 7. Product Specific Data 6a. I am claiming a Generic Data Exemption because I obtain the active ingredient from the source EPA registration number listed below. 6b. I agree to satisfy Generic Data Requirements as indicated on the attached form entitled "Requirements Status and Registrant's Response." 7a. My product is an MUP and I agree to satisfy the MUP requirement on the attached form entitled "Requirements Status and Registrant's Response." 7b. My product is an EUP and I agree to satisfy the EUP requirement on the attached form entitled "Requirements Status and Registrant's Response." OMB Approval 2070-0174

1. Company Name and Address 0253 - Oxamyl Chemical # and Name: 103801 Oxamyl 27-Oct-2011 GENERIC ID # GDCI-103801-859 

### United States Environmental Protection Agency

Washington, D.C. 20460 DATA CALL-IN RESPONSE 1 Page of 1

8. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law. Signature and Title of Company's Authorized Representative ______________________________________________________ 10. Name of Company N/A N/A

9. Date

11. Phone NumberInitial to indicate certification as to information on this page (full text of certification is on page one) 13. Phone Number 10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.
12. Name of Company 11. Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________

Environmental Fate Data Requirements (Conventional Chemical)
Nontarget Plant Protection Data Requirements (Conventional Chemical)

Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical) 835.4400

850.4100 850.4150 850.4400

850.1025 850.1035 Anaerobic aquatic metabolism

Terrestrial Plant Toxicity (Seedling Emergence) Terrestrial plant toxicity, Tier 1 (vegetative vigor) Aquatic plant toxicity test using Lemna spp. Tiers I and II
Oyster acute toxicity test (shell deposition) Mysid acute toxicity test 0253 - Oxamyl Chemical # and Name: 103801 Oxamyl 27-Oct-2011 GENERIC ID # GDCI-103801-859

C,A,B

C,A,B C,A,B C,A,B

C,A,B C,A,B TGAI

TEP TEP TEP

TGAI TGAI 24

12 12 12

12 12 1 of Page

(10)

(4, 6, 15) (3, 8, 16) (1, 12, 17)

(7) (9) N

N N N

N N 2Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical)

Toxicology Data Requirements (Conventional Chemical) 850.1350 850.1400 850.2100 850.3040

870.7800 Mysid chronic toxicity test

Fish early-life stage toxicity test Avian acute oral toxicity test Field testing for pollinators

Immunotoxicity 0253 - Oxamyl Chemical # and Name: 103801 Oxamyl 27-Oct-2011 GENERIC ID # GDCI-103801-859

C,A,B C,A,B C,A,B C,A,B

C,A,B TGAI TGAI TGAI TEP

TGAI 12 12 12 24

12 2 of Page

(2) (2) (11) (5, 13)
(14) N N Y Y

Y 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS 0253 - Oxamyl GDCI-103801-859

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

16 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

The 40 CFR Part 158.660 indicates that either the TEP or the TGAI may be used for aquatic plant testing. However, use of the TEP is preferred to a TGAI study with a standard solvent. Since chronic toxicity studies involving freshwater fish and invertebrates indicate that oxamyl affects reproduction endpoints of freshwater animals (MRIDs 40901101 and 45067801), data are also required for estuarine / marine fish and invertebrates. Refer to public draft guideline 850.4250 for guidance on Tier II vegetative vigor testing. Refer to public draft guideline 850.4225 for guidance on Tier II seedling emergence testing. Data are required to fulfill this guideline due to concerns that oxamyl may affect honey bee colonies. Data are required for tomatoes only. Data are required for the Eastern oyster. Data are required for six species of dicots from at least four families, one species of which is soybean (Glycine max). Data are required for four species of monocots from at least two families, one species which is corn (Zea mays). At least one of either the monocot or dicot species must be a root crop. Data are required for mysid shrimp. Data are required for acidic systems in which abiotic degradation is minimized. Inclusion of a ferrous iron-poor system is also required. Multiple sampling intervals should be included within the first hours after application in the event that degradation is rapid. Data are required for a passerine species. A passerine study protocol must be submitted to the Agency for review and approval prior to initiation of this study. The draft protocol must be submitted to EPA within 90 days of receipt of this DCI. Data are required for a duckweed species. A study protocol must be submitted to the Agency for review and approval prior to initiation of this study. The draft protocol must be submitted to EPA within 90 days of receipt of this DCI. A protocol must be submitted to the Agency for review and approval prior to study inception. The draft protocol must be submitted to EPA within 90 days of receipt of this DCI. A Tier II study is required. For oxamyl, the Agency already has an acceptable Tier I seedling emergence study (MRID 45546101). However, because a no-effect value could not be determined for tomatoes, Tier II data are required and are being called-in through this DCI. The purpose of a Tier II study is to establish both a definitive No Observed Adverse Effect Concentration (NOAEC), or alternatively, a concentration at which there is a 5% observed inhibition effect (IC05), to be used in a risk assessment and effects determination for endangered or threatened species (listed species), and a definitive IC25 (concentration at which there is a 25% observed inhibition effect) for assessing risk to non-listed nontarget plants. A Tier II study is required. For oxamyl, the Agency already has a supplemental Tier I vegetative vigor study (MRID 45546102). Due to the limitations in the available Tier I study and because oxamyl can be used as a plant growth regulator, Tier II data are required and are being called-in through this DCI. The purpose of a Tier II study is to establish both a definitive No Observed Case # and Name: DCI Number: 1 Page: of

Footnotes: The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement. Use Categories Key: A - Terrestrial food crop B - Terrestrial feed crop C - Terrestrial nonfood crop 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS 0253 - Oxamyl GDCI-103801-859

17 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Adverse Effect Concentration (NOAEC), or alternatively, a concentration at which there is a 5% observed inhibition effect (IC05), to be used in a risk assessment and effects determination for endangered or threatened species (listed species), and a definitive IC25 (concentration at which there is a 25% observed inhibition effect) for assessing risk to non-listed nontarget plants. A Tier II study is required. A supplemental study is available to characterize the effects of oxamyl on vascular aquatic plants, specifically duckweed (MRID 45546103). This toxicity study was considered scientifically sound, but was classified as "supplemental" due to a lack of constant exposure of test organisms to the test material. Therefore, there is uncertainty associated with the results of this study in that the endpoint obtained may underestimate the effects of oxamyl on aquatic vascular plants. Tier II are required and are being called-in through this DCI. The purpose of a Tier II study is to establish both a definitive No Observed Adverse Effect Concentration (NOAEC), or alternatively, a concentration at which there is a 5% observed inhibition effect (IC05), to be used in a risk assessment and effects determination for endangered or threatened species (listed species), and a definitive IC50 (concentration at which there is a 50% observed inhibition effect) for assessing risk to non-listed nontarget plants. Case # and Name: DCI Number: 2 Page: of 2

### United States Environmental Protection Agency Washington, D.C. 20460 LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE 0253 - Oxamyl Case # and Name: 1 Page: of 1

352 E. I. DU PONT DE NEMOURS AND COMPANY

(S300/419) Co. Nr. Company Name Agent For Company 1007 MARKET STREET Address City ZIP WILMINGTON 198980001 OMB Approval 2070-0174

State
DE DCI Number: GDCI-103801-859

# LINKS TO FORMS: The pesticide registration forms that are listed below can be found at: http://www.epa.gov/opprd001/forms/ Link to C onfidential Statement of Formula and Instructions (Form # 8570 -4 

# ) http://www.epa.gov/opprd001/forms/8570 - 4.pdf C ertification of Attempt to Enter Into an Agreement With Registrants for Development of Data (Form # 8570 - 32 

# ) http://www.epa.gov/opprd001/forms/8570 - 32.pdf
C ertification With Respect to Citation of Data (Form # 8570 - 34 

# ) http://www.epa.gov/opprd001/forms/8570 - 34.pdf