EPA Registration 264‐418

Vol.2
JocJ 

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United srlru Roglstration opp Identifier Numb., 

oEPA Environmental Protection Agency 7.. Amendment 

W .. hinoton. OC 20460 Other 

, for , I- I I 

I. CcmponylPloducl Number 2. EPA 3. Plo!,o$od Clu:tific.tkln 

264-418 iI o Nano o Rul/iclocj 

.i;,c;:;b- ,'N~" CaUon and T obaCGQ ','!' ,?? 

5. Ntml .nd Addrus 01 AP9~e.nl Ilnclud. ZIP Cod_} ~._~.P'dit'd Reveiw. In accordance with FfFRA Seelion 31en3! 

~axo~ CropScionco ~~!!f!. 'my ploduct is sfmRar or identical in compositfon and fabeUng 

. ~-R; 120t4.2T.W.AfexanderOrive 

1 I fl<lflyfe Palk, NC 27709 Reg. No. 

D Ch."k it 1111$ i$ .new addr,ss Product Name 

, ,-II 

[2] Amarnllnenl· f.pl~n b.lo ..... U FiMI printed lab,11 in replonlo 10 18 Agency 1IIIel detod 

'''''m'''''. ,. , •• , •••• ,. AO'M' "U,' , ... ,. o ~M. Too' ...... pile.II,,". 

NotiUe.lion· Expl.in billow. o Othll. Exp/&in bolo ..... 

Explanation: us. oddilion41 Plgoflf i/ ne.:usory. 1"'01 l"tlion [OM S,,'uon 11.1 

REGFEE: Amem!menllo RegiWation· Re!}lsltatk!n 01 Altemale Coolldentiaf S[!Ilements 01 Fonnwa (CSF$). F:ulllllck, FEE: Not Applicable. 

JUSTIFICATION: Tho ploposedAllcmale CSFs reReel eMel amoodlOOnl.$ 10 tho CSF fot the MUP, 8aw- 250 (EPA Reg. No, 264.0$11). or tho US!) m MW 

MUPs forwhich App~caUon& f<lf RCfJi![rnliolliNnottdm&1IIs MIl bIllng submllied coocorrcnUy with thiS subtnl.$s!oo. No nowdala IlIGuiloo lor [no PfOPO$Cd 

amendment to [no subjm;:t ond usn producl- ~Iy 00 OJ6sl[nG dllia on mo III [he EPA. No chlll'lgu made [0 the eomposll1M of tho and U$O ptOOwct. Cutailed 

jvsll5t:.alloru:l provided Itt Iho attached 1etter. COUTACT: Oanlello A.l.'irochcHo, 9[9154S,27!8; cMa~; Da.n!eHo,Lolochel!oObAyltreropfdCIlCII.CQm. 

'III 

,W., , Pec:kell~no 

EFO''O 

WillI Schtbl .. Plekecino 

12TS~:~~" G'" By" N. N, N, PI'stic 

I ~;:: L' 11 ~'(u· No •. j)~. ~ .'!' ........ gl Untt p.ck.ging wg[. • N •. '" , 

, 

01 N"t [n/ONTIelion .•. "",., , 'II ..... , LJ ·I·~'''·'' ! 6. M'M3r In Whlc:h lAb,1 h~ AW .. d [0 Puwuct 

El~i:':!fj:' o Ottar 

I-IV 

I. C,.'KiP,'" • iI_ dim"" '. ", 

N;:rCiIO A LiltocheHe "', Telephora NI. Unclude Ar .. Cod", 

RIl!J15lraffon . ; (9t9) 549·27 fB . _~~_ •• :. 

Certification t;, O,[:t!r-""don 

I Artily th,[ tho $'-I<If1\MIs I hava made on lhis fOlm and lIII,nethmants 1I'!alelO ola tnlo. 1ICC:llre[a and 

. : 

,:"ee ••• 

lecknowl.cge 11u[ any kno .... llnglly /fl" or mi$/udinO ,""_n[ moy be punishable by 1In11 : (S""",edl both under ,. lew. / • 2. ';0 .. '>0 ((;$ -t II/JJ/~ 13, nUl :. • • .A .. :: • .. Reg!slration Manager, Inseclicides • • • 

•••• 

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'4. Typld Name .. :. • • 5.01[' •••• 

Danielle A. Larochelle September 17. 2004 • • •••• 

. -.. I·' ; WhIIo • (PA "" Copy''''' .... , C,'" 
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Baver Crop Science 

November 5, 2004 

IJoCUntellt Processing Desk (WD) 

Office of Pesticide Prugrams (7504C) 

C.S, Environmental Protection Agcucy 

I SO I South Bell Street 

Arlington, Virginia 22202-450 I 

Attenliun: Ms. Linda Arrington, RD 

Dear Ms, Arringtou, 

Rc: \Vitbdrawal of Applications for Pesticide Amendment 

End u.~c Products Containing Ethepbon 

On September /7, 2004 Bayer CropSciem:e submitted sL'"verul application:> 

for pestici(ie amendments tor .. 'od usc products c])Otilining the active 

ingredient Ethcphon. The proposed itnlClldntcnts reflected a) changes whIch 

are not yet approved for the manufacturing llse product Blls..' 250 

Confidential SrnlCmCl!lS of Formula (CSFl» and b) the usc of manufacturillg 

usc product'i which arc llol yel registcred, Base 211 Ethcplton and Etbcpbon 

\1al!ni.1eturillg C(Jl!centratc (applications also ... ubmittcd 9lJ7J2004). \Ve are 

therefore withdrawing the applications submitted flu- the following end use 

products: 

ETHREL1t bm.nd Ethephon Plant Growth Regulator (For Pi!!eapple and 

Sugarcalle) ~- EPA Reg. No. 264-257 

FLOREU~'.' brand Ethephon Phlnt Growth Regulator- EPA Reg. No. 264-263 

ETI-lREL® brand Eth"'phon Plant Regulator - EPA Reg. No. 264-267 

CERON£¥: brand Ethephon Plnnt Regulator - EPA Reg. No. 264~377 

PREpr~l brand Ethcphon Plant Regulator ror eQUOl! - EPA Reg. No. 264·380 

pR.EpTM brand Ethcpholl tor Cotton tllld TubaeCl) - EPA Reg. 1\0. 264-4 [8 

FLOREL® brand GjR Plant Gro\\.1h Regulator - EPA Reg. No. 264-543 

FfN1SHltr (j PRO [Iarvest Aid tor Cotton· EPA R"'g. No. 264~ 703 

Fur your convenicrn.'c, copies olthe App[kations for Pcsticide Amendmeltt 

,EPA Foml 8570-1) submitter! on September [7 for these- proullCL<; are 

attached for referenec. 

Ple,lsc schedule the review olthe Applications submitted OJ! Sept .. 'mher 17'" 

proposing CSF amclldments for Base 250 lind the registration oftlte llew 

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November 5, 2004 

Ms. Linda Arrington 

Page 2 of2 

Withdrawal of Applications for 1)I..'Sticidc Amcndmcnr (Cont'd) 

manufacfuring usc products, Dase 2!! Ethephon and Efhcphon Manufacturing Concentrate. Once 

these aCfions arc complefed, the amendmenfs for rhe producfs listed above will be rc-submiffcd. 

Please leI me know if you need any additional iniOrmatioll. Yon C311 reach me 31 (Y!9) 549<17!R or hy 

c-mni! at D.gI:!l~!lu&;:~i',.,",Hr~tw)£Tgill!-.'t£_Jf'_IJ.t-t_C{}.!l! .. 

Sincerely, 

Dank!!c.l\. L.1fochc!!c 

RcgistrmioJl Product /I,'!unagcr 

cc: Ms. Cynthia Giles Parker. RDiPM22 

AltacbmcnlS 

CarT. t\o_ daLll:!-J)4 

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Bayer Crop Science 

Kovembcr 5,2004 

Dllcument Processing fk-5k ('1'.'0) 

Office of Pesticide Pmgroms (7504C) 

U.S. Environmental Pwtection AgCl1C), 

1801 South Bell SlreC! 

Arlington, Virginin22201-4501 

Attention: ~1s. Linda Arrington, Jill 

Dear Ms. Arrington, 

Re: 'Vithdrawal of Applications for Pesticide Amendment 

End Use Produtts Containing EtbcptlOn By!"" (;,;pS~,!,,~.~ 

1;11" 

r" C !k" 1::{!'>\ 

PTI'\ lie ;:710!) 

"i.1 S!S~As<nnL 

On September 17, 2004 Bayer CropSeiencc submitted severnl applications 

for pesticide nmendmeIlls for end use products tontaining the active 

ingredicn\ Et1tephou. The proposed amendments reflected a) change~ which 

are not yet ttppruved for the manufacturing usc product Base 250 

Confidential Slatcmeul~ ofFonnula (CSFs) and b) the Use of manufacturing 

usc prodUCl" wllie/; are 1101 yel registered, Base 2J I Ethephoo and Etbephon 

Manufacturing Concentrate (applic.1.lions also submittt.:"<i 9//7/2004). We are 

therefore withdrawi11g the applications submitted for the foJ/owil1g cnd tLSe 

0'(' i,C'}( ~ products: 

It c-'t' t' 0 V'I _ ~J .: tt..,,/: ""'-w.::t:s- L12.::.... 

D 3.5-i\l7,2/S 771 't 1'1 . 5 e'" . ETHREL® brand Ethcphon Plant Growth Regulator (For Pineapple and 

wl<V\ • Sugarcane) ~~ EPA Reg. No. 264-257 

FLOREL® brand Etbcp/ion PlaUT Growth Regulator ... EPA Reg. Nu, 264-263 1) :SSl "3 7 3js-771 Y. 2.0 

ETIJREL® brand Ethcphon Phmt Regulator ... EPA Reg. t{o. 264 ... 267 D :s S 1"'3" 7 L-f / S 771 L{:2.. ! 

CERONE:[t brand Ethepbon Plant RCb'1lJator ... EPA Reg. No. 264·377 "0.3 S l '87.s IS7 7 ! L{ '22. 

PREplM brnnd Ethephon Plaut RegulDlor for Cotton ... EPA Reg. No. 264-380 D35 I 'g 7b/ S 77 (Y 2.. 3: 

PREP Th! br:md Ethephon for Colton and Tobacco ... EPA Reg. No. 264-4 J S D 3 S l '8 77/ S 7 7 ! Lf 2 Lj 

FLOREL®brnnd GiR Plant Growth Regl1JlltOr- EPA neg. No. 264-543 1)35 I 'g' 7'6/ S 77f Lf 2 S 

FINfSH® 6 PRO Harvest Aid fur COlion - EPA Reg. No. 264·103 t> 35 (~7 ~/.s7 71 LJ. 2 C 4~"<"-~ 

For your convenience, copies ofthe Applications for Pe.\licide Amendmcn( 

(l~PA Fonn 8570-1) submitted on September 17 for these pmduets arc 

attached for referente. 

Please schedule Ihe review of the Applications submitted on Septcmber 17!" 

prop().~ing CSF ame11dments for Basc 250 and the tcgis-:rlllion of the new 

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November 5, 2004 

Ms. Linda Arrington 

Page 2 of2 

Withdrawal of Applications for Pesticide Amendment (Cont'd) 

manufacturing usc producls, Ha..<;e 211 EtllCphon and Ethephon Manufacturing Concenlrllle. Once 

these actiuns i:Hl: CllUlplcled, the amendments for the products listed above will be re·submitted. 

Please leI me know if YOll need tiny IJdditional iluormation. You can rellc!; me at (919) 549-2718 or by 

e-mail at ll:Jlli8lwdrr:~bc!!c'd'haxIT..cJ:!}Jllii.£!!.£.S@!.D. 

Sincl:rcly, 

Danielle A. Larrn:hel1e 

Registration Product Manager 

cc: Ms. Cruthia Giles Parker. RDIPM22 

Attllchmcnb 

Corr. No. daU 12-04 

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I )11CUm.:m 1>1 OC(':"Slll~~ D..-:sl 1\\ 'D i 

(ltYic.: or Peo.licldc Pfogl'.illl~ (75il..J() 

!' S EnVirollll);.'!II:d PI{I!cclloll A!!':Il"~' 

i i.;()! Suuth IkE '>Ir<:rt 

\ri!l1ghln. \ irglillil ~2202-45(Jl 

·\IfClllion, ivh 1.lI1d.1 :ll'rJllpIUIl. Ttl) 

R~' Wilhtlnmal (l( AppUclllinn.\ lor PcstiddL' Amcmlnl{'llt 

End CSt: PrndlicH C(lIlI:lillin/.i Elhcpilon 

/ 

On Scptr:mD<:r \1 > 2()O"; B:1Y("I" CrDpS:.:ienc..: :.u!mll\\ed s\:\'na\ ;lppiIC-:1Illllh 

for ptstil:id..: ;lrlicOdn1(';1ts for ,'1)(1 Ih(, ptnducts containing lilt :\;:llvC 

mb'l'cd'lL"lIl Hh..:pihll:. Tilt, prop0~i.'d ;llllclltlmepl~ n:i1c..:-r..:d ai c!i:ll1g;:s WhlCh 

3r~' DDt yet :lppliH cd {,:lr IhL~ Illanlli:H:nlfmg the prl)Jucl Hil-..;e 250 

COllfidcnlui StIICl1i:.:n;s 1)1' hmll1li,1 (CSFs 1 :iIlJ hi lht: use of lllanlilaCllli"ing 

11:'.(' pmdw:t:s whidl :lrc n,)! yet n:gLslcrd, 13.:15<': 211 Elln:pllllil :Inti Uil~pholl 

Manti i;ICl1lnng (\IIlCnl1rnlL' (aprnC<llI011~ QISll SOi.llll!U<!d \)' I i.'::'n(4). We ;ire: 

1ilL'rcfon: wllhdwwing !lle :ljlp!ICllioll:> SllbfHllH.:d [,)r lht ~)ilowing end Ib": 

pr(llhlcLS: 

I-,TII RJ: L ji, hr;!l1d l',!hcpholl 1'1,1111 r;-r,Hvth Regulaln:- ll-()r Pi Ilcappic and 

S\l~3r<,';lIlC:)'~ I~PA Reg. 1'.11. 26-l':157 

FLORH 11 hr;lIld HhepiJlIll Planl UrO\'.'lh Rcgui:Hl1r' rI'A Reg. 1\0. 264-2(,] 

f-T! I RFL J<, bra no Elllcpiloo 1'!:1111 Regu la Ilir - I--.P r\ R<.'g. 1\ Ii. 264-267 

(THO:-JFA br:lll<:i Llllt.'piJlJll Phllt! R<:g.uhllir FPA Reg. 1\0, ~6-1,.n: 

pgEl'r,! brand FI11Cpl10ll Planl R<!glllahrr I'or('nllnll· EPA Reg. 1\1) 2fJ4-3XO 

!'RLP\V (;1':11111 Hlh:piJoll fM CI,II()n3I1U Toh:IL';;,)· I--PA !l.eg. Ko ':(,4-..jiX 

FLOIU?L lZ bnlHti CFR Pbnl Growth Kq;'ll~nli)r - IJI A Reg. 1\0_ 26'-\-:;4_~ 

1-1\11:-;11 ~ () PRU 11'1r;'{:~1 Aid )(lrO,l1ol1 - i:PA. Reg. ~o. 2(,~, 7fB 

1-'01 y0\1r C\lil\-\:lW:llce. COp1C_-:' IJrUw Applicatwlt., jilr f'c~li';lde AnIClltil11'-'IlJ 

iI-,rA ronn K570·! I 'lIhlllillC-d on Sep!<:mh-cr I'; [i)r Ih~se prudlk1s :lfC 

:l1(;IL'!l,'1i 1(11 n:fcr..:nc\" 

ric;lsL S,'hLJllk the ret lew ':If tiTL !\pplit<l!IIJIlS ';1I!ml ined 0)\ Seplel1lhcr I 7" 

(1rl)p(,';ll1g r Sf ;)!ilelldmcnl" fill' 1},I'c ~511 alld tile ,egl~lr<llH'n l,r IIIL 11(\\ 

, , , . 

~. (/y" ,. < ;:. ~. '" .. C , • 

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\'o\l':mha:\ ':0(14 

M~, Lind:, !\rnligHlIl 

Page.2 of:': 

WilhdnlWal Dr Apllliratillm ftJr Pc')ticidc Amendment (Cont'd) 

manllfaZ'tllnng n;.;;: pn)'!II-(!~, lkh,: 21 I Elhepil()l1 :md l"lhr:rh()J1 \iamd:l{,llIring C(ln~'cnlraJe, (JIK:': 

thes;; ,1(:)1(l1l~ m~' {;l)mpkled. tile .l!l1.:ndmt.'IlI_" j(lr lh<.: pn'Klil(l~ 11S((.'d ahove will b<: rt:-!.lIbntlllcd 

D:midi.;: A ! .amendk 

Ikgistnlllllil Proilud \LHwg..:r 

8 - --------- ----------
, __ '''~ ____________ ~u~ _ ______________________ ~ 

"'- '" ", .. AI , ,.,.." 

Unit~Stot .. OPP Idandfi., Numbtor 

.oEPA Environmental Protection Agency 

Wuhil\qton. DC 20460 

Registration 

Amendment 

Other 

';: 

Cottotl and Tobacco 

Addrus of Applieont fktefude ZIP Cod., 

t Sa.yer CropScience 

1~.O._Box 12014, 2 T.W. Aleltander Olivo 

Research TrianGle Park, NC 27709 

o en"k. if f/li$ iz. "flW .ddro.ts 

IIor 

I'·EPA 

; 

, -

PM' 

Team 22 

3. Ptoposod CfusiHcadon 

o NOM 0 ft,.meted 

6. Eltpldi(ed Reveiw. In accordance with FIFRA Section 3{cIl3) 

/bllil. mv product Is similar or 1dentic.tlln composition and {abaling 

t~,_ EPA Reg. No. _____________ _ 

tNam. 

- II 

~ Amendmlnt· Expteln below. 

== 

= 

." 

1Q nnubmlnlQn in ,uponu to Aoency I.He, dOfo.l ______ _ 

• [] Notilicetion· e,ploin below. OUw· Explain b"'ow. 

Explanation: U!e odd,tlon&l p"lIohl if neclI."'ry. IFor nCI,on I end Sectlon 1t.1 

REGFEE: Amendmentto Regi5trndon· RegIstration of Alternale Conrlll'enlial Statemenls of FonnulaICSfs). Fasl !mel!.. FEE: Nol Appllc:oblo. 

JUSnFICATIOH: Tho ptap!lnd Aiternate CSFs roneet eilher amendments 10 the CSF fer tho MUP. BlIMI 250{EPA Reg. No. 26-1-51 I). Oflho uso of nfJW 

MUPs for which App~C<ltlOtl.slor Reg!~lrntianfAmoJ"ldrn&fl1s am bclng submilted COIlcurrll1ltly ..... ith thl:l submission. No new data required for the proposed 

IImendlMnl to tho subJect eod use produet - rely on eJdstfng dala on No at tho EPA. No change mode 10 the C(lmposilion ef tho end use pI"Oduct. Dlliailed 

llatlricallons provJdoo in IhG attachod luuor. CO~frACT: Daniello A. llllod1ene, 9t9/549-2711l; eMa~; Danlclte.Larocho1lc@bayoreropselence.com. 

I-m----------------~ 1. , P,,"" Y/1Q .. , , Peckllginll Urn, 

By" r y" N. I--- N. 

11 must I",;"!'" .~. lin . , .. , 

! U Lob" U i 

! 6. MlnMr in Which Libel I. Allixld 10 PreQuct 

I. 

No.por 

(:ont~tr 

I,' R." 

I.~er Soluble Peckellinll 

!- V .. 

No 

I -IV 

No. p.n eontjljn.' 

o Oln,r 

, Insecticides 

Certifk:ation 

.. <Lob." 

... , . 

Telophon. No. 

19t91549·2718 

I certify Ihet tho $l.at,monts I hoy. mild_ on thill form "nd all .nechmtnts Ihe,.to 0" tNO. oceutet. end ; : I 

t ocknowlodgo th4t ony knowHnatly 1&1111 or mi,ll&ding .telement moy bo pUnishlbll by tine or \m9rilOlVnOnt or • ,. 

(jJ;;;~ {/tllilf 3.TI'., ::~:: Registration Manager, Inseclicides : 

14. Typ.d N"",. S.DItI 

Danielle A. Larochelle September 17. 2004 

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tStamped) 

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c' 

I,Cynthia Giles-Parker,Product Manager, Team 22, Fungicide 

Branch, Registration Division, Office of Pesticide Programs, 

Office of Prevention, Pesticide and Toxic Substances, United 

States Environmental Protection Agency (EPA), certify that the 

pesticide product(s) listed below is, as of the date of this 

letter, a registered product under the Federal Insecticide, 

Fungicide, and Rodenticide Act (FIFRA), as amended, and that as 

such, the product(s) may be Bold and marketed in the United 

States of America as authorized and limited by FIFRA. A true and 

correct copy of the product label approved by EPA is attached to 

accompany this letter. 

Registration of this product(s) with EPA also denotes that the 

registrant listed below is responsible for ensuring full 

compliance with all laws of the United States of America, or 

governing jurisdiction, regarding the sale, storage and/or 

disposal of the product(s). Further the recipient of this letter 

is on notice that the status of the referenced registration 

and/or the accompanying label may change subsequent to the date 

of this letter. EPA assumes no responsibility to notify the 

recipient of this letter of any change in the status of the 

registration{s) and/or the product label for the product(s) 

listed below. 

f " 

.", EPA has issued registration numbers for the product (s) listed 

below to: 

Bayer CropScience 

2 T,N. Alexander Drive 

Research _Triangle Park, NC 27709 

EPA REGISTRATION NO. PRODUCT NAME 

264-418 Prep brand Ethephon for Cotton 

And Tobacco 

/ . /J;;> Cynthia Gi s-Parker 

Product Manager (PM22) 

Fungicide Branch 

Registration Division{7505C) 

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11/27/02 12:33 REG1STRATION)RTP ~ 917033355596 

'V Bayer Crop Science 

Fax 

To: From: 'EPA'· ---------- ---M-'-'-es"n~.-a-J-, 80:-r-oo-,.-

ttn' Document Processi Desk: Be Wlrriams Re ulat Affairs. r=:==="""-="-""''''-'.!="'t~~=~-'·····----c ax: 703-305-6596 __ I 01: 919-549·2425 1:-"',,-,::==: -"1='------- , ax: 919.549-2545 

; mall: Meshea,Brodie ba er 'ence.coml 

This isla request \11M (~l gold seal certlfIcates of roglStralion for EPA Rog. No. l64-4S7 + 

MOCAP lSG, ...... EPA Reg. Nq, 2&+418 P"!e. bland Ethep/!on for Cotton andTobacco, 

Pleas. send them to me at the following address.,." C r --:7 11J /Wn~ .. l;rf/~J - /tRvk>eY 

Meihu Brodie 

Sayer CropScience 

PO. Box 12014 

2 T.W. Alexa""'" Drive 

Reoearch Triangle Pari<. NC 27709 

TharI< yeo lor your allllistance. Please caM m. ~ yoo have any queotiOflS or concems . 

Regarde, 

L.J:2~ ~.~' Sr. Reglstnotion AUociate 

Bayer CropSeience 

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C 20460 

Prasad Rao 

A ventis CropScicncc 

2 T, W. Alexander Drive 

Research Triangle Park, North Carolina 27709 

Subject: 

Dear Mr. ROoD. 

Prep brand Ethcphon for Cotton and Tobacco 

EPA Registration No. 2644! 8 

Your label amendment application dated August 12. 

2002 

OffiCE Of 

PREVENTION, pESTICIDES 

AND TOXIC SUBSTANCES 

The amended labeling referred to above, submitted in connection with registration tmdcr 

the Federal Insecticide. Fungicide and Rodenticide Act (FIFRA). as amended is acceptable, 

provided that you comply with the f()!lo\\iing conditions. 

I. You must make the following changes to the labe!: 

n. At every place in the label where it occurs, "PREP" (without any additional prorlm:l 

name) or "PREP brand Ethephon" must either be changcd to a nonspeciJ1c tcml such as "this 

product" or else changed to '\PREP brand Ethepboll for Cotton and Tobacco", the completl.~ namc 

of the subject product. "PREP" and "PREP brand Ethcphonh are also pari of the name of EPA 

Reg. No. 264 M380. 

b. In the "IF IN EYES:" subsection of the "FIRST AID" section. in the second SlalCl1lc.:.'ilt 

add "eye" after "then continue rinsing". 

c. In the Jirst sentence in the "PERSONAL PROTECTIVE EQUIPMENT (PPE)" seclion. 

add "made of any walerproof material" after "chemical resistant gloves". 

d. In the first sentence in the secondMloMlust paragraph in the "AGRICULTURAL USE 

REQUIREMENTS" section. change "chemical resistant gloves such as any waterproof gloves" lo 

"chemical resistant gloves made of any walerproof material, such as nitrile, butyl, ncoprene, or 

barrier laminate". 

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e. Move the sentence "Do 110t contaminate wmer, food, or feed by storagt: or disposaL" in 

the "STORAGE" subsection of the "STORAGE AND DISPOSAL" section 10 just afit!f the 

"STORAGE AND DISPOSAL" heading, change the name of the "STORAGE" subsection to 

"PESTICIDE STORAGE", and provide appropriate statements for spills specifically (not solely 

spills), in this subsection. 

L In the first sentence of the second paragraph in the "Specific Directions" column of the 

"Over-The-Top Applicaliol1" row in the "TOBACCO (FJue-Cllrcd Only)" table at the top of page 

6, Change H, •• using thret! nozzles (one nozzle tips over .. ," to " ... using three n07.2les (one nozzle 

{ipover ... ". 

2. Submit one copy of your final printed iabcliag before you release the product for shipment. 

Tfthcse conditions nrc not complied with, !llt: registration may be subject to cancellation in 

accordance \\ith FIFRA section 6(e)< Your release for shipment of the product bearing the 

amended labeling constitutes acceptance of these conditions, 

If you have any questions about this letter. please contact John Bazuin at (703)3()5~ 7381 " 

Sincerely yours. 

Cynthia L Giles~Parker 

Product Manager (22) 

Fungicide Branch 

Registration Division (7505C) 

Attachment: Label stamped "ACCEPTED with COMMENTS" 

13 
TM 

J..J;"' 

-~ r 4 '" , v. PREP brand Ethephon FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: EJi1ephon (2-ChloroethyJ) phosphonic aci(l" ............................. 55.4% 

INERT INGREDIENTS: , .. " .... , ..................... ,,44.6% 

*This product contains 6 pounds elhepholl per gallon. 

EPA Res. No. 264-418 EPA Est. No. 264·PA·01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

Sl u~t«lIlO t'nlierlde Ja ('liqueti'!, busquea algui!.'11 piHiI que- se Ja (',wJiquea listed en detallt'. 

(If 1'ilU do nOll1lldentand 1he lahd, firld wnll'Olli' to explain it 10)'011 in detaiL) 

for MEDICAL And IBA.M1tQRTATIQN Emergencies!llilY Call 24 Hours A Day 1·800·334·7577 

1 1 

The U5C oj 1l1i~ product lor it vMiety of plant growlh regllJallOn US5 ;Ul' prote<.ted by United States ;lnt! foreign patents imlulhng 

US Patent 4,240,8 t9. No license 15 grarl(ed In Uk this prodlJtt in countries olJler O)~n the Urtit('{1 S1atl'\. or Jor any ure not (unlempJated bi' this 1,jj)eL 

LiabWtv , fo ,~ ate nmm I J' Igl'n)"nt , , na , res It J Je of lhi~ product Oll~ldl' 11 f' Un ted Slate~ " rom U~l' or $<\ L , tt 

• 

~ .. : : •• • • -- t1-JiHYE5: • Hold cye open and rinse ~Iowlyand gehJlywitl1 water for 1S-16 mi!,!ute!i. • •• • ••• 

• • • 

• Reflll.we contact lr,nses. if pre$Cllt, attcr the l1r;t S minutf5, then rontlnue rinsing. , 

• • • • i. <:>11 . ", • • 1 i • " •• • 

IF ON 5KJN OR • lake off (J)ntarninated polhing, : .' tt " CLOTt4JNG: Rinse ~n immediately will (p\enty-oJ watt'r for 15-20 mln!lte~, • • ••• 

• <:>11 , i . . t ,,,d,"" :' .. 1';-: .;;.;;;:~ • Jmml'5l1att:ly fa!! il poison-ton)rQl (ente! or doctor fOf treatmenl advice. . . 

• Do not 'Induce 'iomhing 1lflles5 toJd to do $0 by a Miron controJ (enter or doctor. 

• Haw: person sip a gla~of .water If able to swaJlow_ 

• 'moo, i • 

For MEOlCAlEniergencies call 24 Hours A Day 1-800·334-7Sn. 

"'~ , h~u 1 " , ,d""", 

NOTETO ,.;. ;:;;;,:1,;;, should be given to . ~tJ1:; , , t , ;,h, 

.--

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE (,lU!eS irre\'cr\ible eye darn.'!);c and skin hUrris HarmJuJ If swallowed or absorkd tllrolJgh skill Do nOl get ill e)'C'S, On skin or 011 clUlhlOg. 

PERSONAL PROTEGIVE EQUIPMENT (PPE) 

lIpplicators and olher hant]len II1U51 we,1f ((JI'erd]Js OVI!I ,horV.ic't'I'cd shirts and short P;HltS, ,hemic,lJ rl'';islanl gJ{)I'l'S isudl as Nitrile, BUlyl, Neoprene 

and/or BiHfler laminalej, (heml(aJ-r('\istJnt 10otw(w pllJS '>I)(ks, prolcttlve CYCI¥{'dr, chemital·r('51',t.lnt htwlgear for t:lI'erhead exposure JfrlJ (I;('nli(;llrMistant apron whl'n cleaning t.'i\III'prnelit or mixing and Joading. 

DisciHd (IOHling and other absorbent nlaterlals that hayc been drel rched or heaviJy (olllamin;tt.;d with this products con(entrate_ 00 not reu~l' lhem. 

follow lI1<1nllla(tllrer'~ in~tru(1iom Jor cleanmglmalnlainmg Pf'F. If no ~uch in~lf1rniun~ tor lVasJl<lblf'~. u~- ddergenl and hot waler Kf'r'>J ;llld wa~JI 

PI'E sep.natl'ly Jroll1 other lanndlY 

Wllell handl('f~ U~' dosed ~yslcnIS, enrJosed cabs, Ilf dlroilll in a rrlJnnff thilt Jlltets thl' requiremcnb Jisll'd m the Worker Prote(lion 51"nliMd \WPS) 

tor agri(lillllral pl"iticidl'S [40 eFR 170 24fr (d) (4·6)). lhe hdrllJi('r prE requit('lllfrlts In"v be reduced or morlilicrl as spe(iJied in (be \'IPS 

14 

I 
user Safety Recommendations 

Users should wash hamh brfOf!~ ealing. dl jrl~ins. (hewing gum, USillg tobacco or USillg the toile!. 

Users shuuld remort: clothing immediately if pe~li(jd" gels inside. Tllen wash body thoroughly ami pul 011 clean clolhing 

Us<-rs should rcmore PPt Immediately after handling !ilis prodllct A~ soon as rossl"ble, wash Ifloroughly and dlilnge into clean dolhing. W<l~h Ihe 

olll1.ide 01 glo~'es before relilovinS. 

ENVIRONMENTAL HAZARDS 

Do nol apply directly to waler, or In area$ where surface waiN is prMenl ur Iu Illlertidal areilS below Ihe mean high waler mark. 00 not (OnlilllllO;jle 

waler when disposing of equipment washwaters. 

00 nol contaminate WJlcr IISed for irrigation or donltosliL purpusc~. 

SPRAY DRIFT 

Moid spray drift Do nol aPfrlr when weallier conditions may CilU~ drift, Do nOl allow !llis Jlroduct to drift on to non·target areaS. Drift Olay re\ull III 

illegal re>idul'S or injlllY to adjacent crops alld l'!;gelation, io We form 01 leaf }'eJlowlOg and delolialion. ro avoid lpray drift, 00 N01 apply <IN(Jlly 

when wind speed is greillerlhan 10 mph or during peri ods of femper;1!ure inversions. Use of larger droplel $"Ile. will also reduce sprdy drifJ. 

AVOIDtNG SPRAY DR1H Al n-ll: AI'Pl!(1IT10N sm tS H-lf RE~PONSJfJJU1Y Of- mE APPLICATOR. 

The interaction of many eQuillnlellt'i1nd,wealher-rel<l!eJ fa(!Or5 delermine the potentiallur ~pc.1r drifL The applicator is respon;ible lOr considen'ng 

aJi these ladors when making decisian~. 

lhe following drift man~gemenl r;>qUlrl'nlent~ musl be foJlowed 10 .avoid ulf·1Mgel mUl'ernenl from .lcrial applications 10 agricultural lield {fUIII. eu:se reqlliremenlS dn nor "'Pllly 10 forestry applilaliuns, public 11('<llth uses or to <lpplltatinns I rsing dry forrnulaliOl15. 

1. The diS1<lnceof tile outer fliOSl nlJalb onlhe boom rlHrst no! exceed 3/-11he lellg!!1 of the wingspOln or roWL 

2. Noz;:les mllst alw<lYS poinl backward parallel with !lIC air SlrCilnl ,111d nl'Ver bt: poinltG dowllwards more lllan 45 degreC5. 

WilerI' stall'S hOlve IllOfe stringent regulations, lhey sholdJ be ob~r\'ed, 

The applicator ~hoilld be familiar With and take Into aCCOlrnt lhc Infofllli\tlon col'Cred in 1I1e Aeri~1 Dnit Redilctillil Advisory belol'o-: 

AERIAL DRIFT REDUCTION ADVISORY 

[This section is ad~isory in nature and does ilol sllperwde tile mandatory lam-I requirement5j. 

INFORMATION ON DROPLET SIZE 

fhe most elk{live way tu reduce drilt PQlenlial is 10 apply large droplf'h. Ihe best driJ! m~llagclt1ent strategy is to apply the lilrgC5t droplel'.. tllat 

pro'iide sufficient wl'era:;e and mrnrnJ. Allplying larger droplcls rl'-ducr~ drilt polt'ntial. hut will 110t prevcnt drift if applications are made illlprnprrJv. 

or undel unlal'nrable em'irorllnenlal condiliuns (Si.'e Wind. T emperatllfc and !Jumidity. and Temperalure tnverslons). 

CONTROLLING DROPlff SIZE 

Volume - U..e high flow rate Iiontes to apply the highesl wdctiul ~pray volume, Noales Wilh higher rated 1101'6 prndllt(' larger droplets. 

Pressure - ()() nnt exceC'd the ooa.le mallufactllfer"~ rNomlllendcd pressures, For many nozzle types tOlVer pressllfe produce51arger droplet5. When 

..-li[glll:'r Ifow r,1leS arc nrcded. lile h'lgher flow r<lte n07Zles 'instead of increasing prewre, 

.Imber of Iloules· lise lhe minimllm number of novll's !llaf pHll'ide unifufOl coVl'rag~'. 

Nonie Orient.l!ion' Orienllng nOl.l.h '}(l that the spray is releil\€(f flarallel to the ailSlream prorJuces larger droplets th~n oUler orienfiltiom iind IS lhe 

recommended praClKt'. )igniflcalll deJicllioll fW1l1 hurilom~l will redure droplel Slle and incrt'a~e drill potenliaL 

Nonle lype· u~ il nuaJe type :hal is dl'5igncd lor lhe- inlended i111pllcatlOlt Wilh HlO~t nOllle lypes, uarrower spray angles prudutt' largrl uroplCh. 

Consider uSing low·drif! nOllle~, soilif ~lre,lnl nonles oriented Slrdight biltk producc 11 Ie largcst drupll'b and 1I1e lowest drilt. 

BOOM LENGTH 

For SOme UY..' pdl1erus, rt'dlrcing lhe dfeClIYC boom lellsth to I'!ss lhan 314 of lile willgl/ltln or rOl0r tenglh InaI' funhcr redute drifl wilhOin R'rJIIClng ~wath width. 

APPliCATION !lEIGtJT 

Application, should not be made at a heighl gleatertilan10 l("et aoove tile tup of the target pl;:lIlts llOles, a greater lleight h re-quired fOf arruaft ~afety. 

Making applicalions-all1le luwht heighl !!Iil[ is s.afe reducd expowre 01 droplets 10 ev~poraliOIl illid wind, 

SWATH ADJUSTMENT 

Wflen application, Me made wlth.l wmwmd. lhe swal!1 wllille displac('{! downwind. Tilerciorc. on tlie Irp ilnd downwind edges 01 !lll' lltld, the 

~pplkator SllOl1ld conl)Jf'ns<lte tor this dhtllacement by adih~llng lile path 01 the aircruit UPWilld SWilth aliju'Strll('lIt di~tanc(' sflould inl(l'iI~l'. with 

Inue<lsing drill polcillial (lligll~1 Wllld, "nailer droJl~, etc j, 

WIND 

Drift polential i~ Inwesl bctwttll WI lid \peeds 01 2 . 10 mpli Hnwe .... er. manr larlurs, il1c1uding druplel 5i7e and equiprnenl type detenlilnf" driJt 

potential at ilily given speed, AppticallOn 511l"lUJd ue al"OId('{! below 2 rliph due to l'ariable wind direction and high inversion ptllt!ntiaL NI)Tf" local 

terrain L,ln 1IIIIIIence wind p.ll1cl ns. hery appliGlt(Jf ShOlIlri he 1:lmiliar Il·ilh 10f<ll Wind palterllS i1rld how they Jffect spray dtift 

15 
TEMPERATURE AND HUMIDllY 

Wilen making applicalion~ iu low relative humidlt)'. set up equipment to produce targ~1 droplets to compeusate lor evaporation, Droplet evaporation 

is mosl severe when conditions arc both hot and rlry_ 

TEMPERATURE INVERSIONS 

Applications should not OlLur during a trmper<ltme inversion btcall5e drilt putential is high. TelOfler.1ture illversions restrict vertical air mixing, which 

Cil\lreS small ~uspendctl droplets to remain ill .llonccntrilted cloud, 11lis cloud can move in unpredictable diledions due to the light varialJlr. winds 

common during inversions, lemperaturc inversion~ aH~ dl<!fdlh.'rized by in(f<'a~i!!g tt'IUIJl~ratures wil h allitude ilnd are common on nighls with limiled 

do\!d (Over and light to 110 wind. nte~' hegin to tonll as the sun sets and ollcII (()Iltmue into Ihe morniu8_ TheIr presence can ~ indicated by ground 

fog; however, if fog is not prerent, inversions can also be idelltihcd by the Illovemeut of ~rnoke from a ground source or an aircrall smoke generator, 

Smoke that la}'f-(s and ruo'<t~ laterilily in il concentrated (loud (undr.r low wind COltditions\ indirates an inversion, while smoke that move~ upward and 

rapidly diSSIpates indicates good verlic,lt air nli~ing. 

SENSITIVE AREAS 

I he fK'Sticide should only be applii?d whell the potential lor drill to adlilcent S("n<;ltlve ~reas (e.g. rcsidential i1feilS. hodie; 01 waier, known habitat for 

titreatened or endangered species, non-target crop~) is minimal (c.g_ when wind I~ blowing away from the >en~iti¥e areas), 

USE PRECAUTIONS 

00 not apply PREP'V brand Ethephlln IrIr Cotton and Tobac(o through 'Hli' I)"pe 01 Ifflgatioll sj-"'telll 

Avoid spray drilt to nearby crops ilS this proriuct will cause ntodific,.\!Ons In pl,.nt gro\~1h Plant inimy or relluced yicld~ will rCSlllt. 

l.lix only tllf amount 01 ~play you ('xpect to lise e;\(h rlay . [}(J not allow mixed 'iohJtiol! to staud overnight 

• DIREGIONS FOR USE 

II is a violalion of Federal law to use Ihis product in a manner inconsistent with its labeling. 

Do not apply this product in a way that will contact workers oc other persons, either dire<tly or through drift. Only protected handlers may be in 

the area dudng applicalion, For any requirements spe<ifk to your State or Tribe, consul I tbe agency re5pon~ble fQl" pesticide regulations. 

Read entire label before using Ihis product 

RAL USE REO 

the thi~ product only in accordance with ib labeling and witll tile worker Prolcctlon Standard, '10 erR part 170. TillS standard contains requirenlents 

lor the protectIOn of agricultural workers on larms, lorem, nurseries, and gre~nhouses. and handlers of agricultural pe"tkides. II contains 

requirem~nh for training, decontanunatiou, notilication, anrl emergency iI!>Sistance. It also contain~ spenlic instructions and exceptions i 

the stah?ll1cltls on this f.lhel about personal prot('(1ivr eqllipillent (PPE), IlotifkatH)n to worker~ and restricto:-d·entry intervals, The requiremenh in 

box only apply to USes 01 this product th~t .1n~ lovered b~·the Worker I'rotcctilm \tiliidard. 

00 not enter or allow workcr entry mto treated dleas during thi" rKtnded-e!lt~· Irlterval (REI} of 4fl Jlmlr~ the Rlt I~ 72 tlours in a(('as where "".~" I I"""'" "s I,,, tllan 25 im hes per year 

PPE required lor early entry to treated area~ tha} IS peouittcd under the WOlker I'wtectiOi'1 standilfd and thaI involves contilct witll anything that 

trcaled such as plant'i, wil or water is covcralls oyer 10ng·~!eL'Ved shirt <HId long p.lnts, chernic;)1 resistant glovts such as any waterproof 

i I re~istant footVlear plus socks. and prote-chve eyewcill. Fm overh!'ad eXflmure, d lenl!cal-resistant headgeoar is also required. 

I· I ' t to trc~ted aleal. 

16 
STORAGE AND DISPOSAL 

STORAGE 

Do not conlamillate Wdtl.'f, food, 01 leed Ui' S'O(Jg~ or dhposal. 

If (ontainer is broken 01 contents h<lve spilled, follow all prc(al1liom iudicillt'd above and deiln up immediately nefOie cleaning 111l, pul 011 !u!lleng;h 

trouserS, long slerved shill, plOIIXtlV('" gloves, a11d goggle<. 01 lacC'shieid Soilk np \JlIll with abwrbent media such as S<1nd. earlh or olhel sirilahle 

materia! ilod Ili,pow oj waSIl' al ~n Jpproved wasl('dispo~! f,lCilily. 

PESTfCIDE D!SPOYll 

re51ieide wastes ,lie <I(IIlel1' llMillllous_ Implorer dlspos<J! of e:x(e~\ rn~li(jl!e. spray mixtlrfe, Of IInStllc IS a violation of h"dclallaw If these wastcs 

I 

:;;~;:;,"":;:d:~;~'P,~OSed 01 by use il(cordlng 10 labd inSlru(liofl\, tOnl-a(t yon! Slille I'eslitide or Environmental (0111101 Agency or Ihe lJazardous Wash~ the ne;;r(,5t f-I)A Rl.'g10nal office lor gUidance. 

DISPOSAL 

rjnse (or equi\'alenlj th(- emrly (o111.'lI1ler5 Theu ollel 101 lecycling or reconrlilioniHg, or pUI1(\\lre ;wd di.,pt)sc of in a sallitary landlill, or 1;";;"""";'0 ';" ;1 allowed by stale and !ocal Jl1lhorilie~, by blllning. If container is burned, slay oul flf ~Inoke. 

RETURNABLE·· REFlll.ABLE COtHAINERS 

use. lelurn thr container 10 Ihe /Xlillt of p11l(ha~ or designaled !oralioIlS, This (onlaincr must 111 dy be Idilled wilh PREP'" brand Etlu:phon 

and Tobacco. DO NOT REUSE TIll. CO~·HAINER FOR ANY OTIlER PuRPOSE- Prior In relillillg, insptct Ihoroughly Inr dalnage such as 

1 and damaged 01 WOrH out threJll~ 011 dosUie dcvlces. Do nol rehll or IldllSpOrt dam~gerl or leaking conlaincr5. (hed;; for! 

i!! I' iris nOI .Ii, I I I 

ERAL INFORMATION 

conON 

A !oliar srlfay 01 PREP'¥ bland Elherhon lill cOtlOH and Tomcro will dccclerale opc11Ing o! malure ullopened COllon bolb and ellhance dclolialion 

which can reSUlt In f.lnlt'l h,uv('sl wilh ,1n In(lra~rl rl.'wwrahlc Yield Pit! 1'''' Ireatlllt'l11 on cOl\on al!ow~ in(f!!a!>Cd cHi(Jency from a once-ovel 

harvest:. 

TOBACCO (fLUf-.CURfD): A lolial spray of PRII"~ brand Elherhon rllonlOh.-'s early. uniform ·yello'.\1ng" olilial UIC lobacca_ PREP'~ ledlln',; r l1f1l1!; time. 

allowillg 1110re efficient use of wring balll space, and increased control over harve'il S(h~dule<,. 

SPRAY PREPARATION 

Add 1/2 10 311 of Ihe lIo-'quirel1 aOlonnt of watel 10 Ibc spray t<ink, 51<111 agildlioll Add the reQuiled arnlluHI ull'REP'" brand Elhephon. Jnd Ihe 

remaining alnounl ot walfr Prep;1fr lJIily a~ Ilwch spray soluliOiI ih (&11 be I1sed on the day o! mixing /)0 nOI allow spray so!otion 10 ~Ianll ovelllighL 

00 nOI $pi!llhe concenlrale{j product on spray equiplllellt, or any ail plane pJrI\, 

ANY SPIl.L5 5110111 0 III RINSW IMMEDIATELY Wlllll'll'NTY OF WAT£R, 

Us(> 01 il nUise lalll;; I~ 111!ltlly I('COnlmendell rnr avoH.llllg pOSSible Wills or {OrlO"lIlr<llro 10nl1ulalion on spray f;<.ll1ipment 0/ allY dil plalll: palls. 

TANK MIXTURES WITH DEFOUANTSAND INSEOICIDES 

Ar'" brand EUu:phon is (Ompallb!e wllh 1JI.I'1, rOLEX", OlOppi. i)l()pp" UII/il'"', GiIlSt,iI"2, Ha/Vade l

- Ml'thyll'aralhioll, GUIliioll1, and Mafalhion{ . 

• EP'~ may be app!ierf in '>CqIlCHCC 01 J~ a tank mixilire (00 NOT TANK MIX WlTIl DESIC(AN15 II' COTTON IS TO BE SPINDLE HARVESTED). tollowaU 

apr!iGlb!e use precaulions <lnll rate pel <iC\t' re(Onlln(;ndalions on !abrh ollflndl1r\s Jflplied as lill1k mixtures Ol in sequence wilb PREP'" bfJnd 

(Ihephon. In some (,;l\C~ ~Iiglll I edudlon io boll opeOing I(;,ponse has been ollser .... ell whell tank IlIixe~ wllh defoliants were used 

Good agilation in Ih~~pIJy tank i; Nlemi,,1 Mid a I,mk Illixiule shOilld nOI hf' al!owed 10 ~I<ind wllhoot agililtiol1 for mOle Ihan 5 10 10 minllle<;. Re;\r! 

<illd ob..elVt' all appropri31c I~be! me dirt'(liolls and precalltions for Ihe delo!ialllS and inslXliddes used. 

NOTE: UNIJER (ERT AIN (OhDITION\ Tr\NK f.IIXTURES Of PRTP'¥ [WAND fHIEPHON WITH DESlCCANTS CON IAINING SODIUM (I-lLORATE (aULD RESULT 

IN nil FORMAIION 01 IIYI'O(HLOROUS AODS WIIIUI 0.'-/ HEATING Will rklll IOXIC ClllORIDf ~UMES. 

1)0 NOl MIX PRfP'" BRAND ETHfPllON Willi AMklONlliM THIOSULfr\TI \UCII lANK MIXruklS MAY RESULT IN fORklATION OF TOXIC ~UM[S 

EQUIPMENT ClEANING 

Because 01 the acidic i1illure ollhis prolluCI, lllolollgcd e~pnsllrt'!O .. pray dtposil will damagc acrylic plasllCs, cNtilin pilint5, i1nd IIlel<lll, 

Ri use Ihoroughly wllh a detr-rgt'lit and w,l1el all exposed ,myjic p!a\IIl-lype lila lei ialS ie.g., aimall wil1dshie-ldsl, and painted slrrlace~ wilhin an hour 

after e~posure 10 Spfily deposils. 

At the end of each day. rinse IhofOliglil\' wiitl" del!'rge-nl Jnd walPr "II the melJI P;llis o! Iht all((dfl and the associaled spr,lY t'quipment exposed 10 

Ihe spray deposlls, 

17 . ",.,,'''---------------
conON 

USE EXPEaED PREP'· ONE MiNiMUM SPRAY APPtJCATtON 

CONDITIONS RAn GALLON VOLUMES TIMJNG 

PREP;REA (Gals/A}* 

P;ntsJA lnSA.1. Act" G<o"d AitHH 

PREP'" Ilot ilIld Illy 80'F or 1 1/3 1.0 6 Apply when the numlx:t of 

BoJJ Opener"'''' liigllcr matute unupenM bolls ;, 

I 5uHicient In produce the Dry ~nrJ 7') to BO~F 2 1.5 .\ III 2 detted (tOp. See below tor lesl 

1113 2.0 ) 01 boll matmity_ Treatment (001 bllt aboY(' 65¢F IInlformly opens boJl~ 7 tu 14 

0< days earlier. 

PREP'" + FOtEX- ltig!1 soil moisture 1i3 025 " 10 5 Apply <\ to 7 days prior In 

DefoHantTank MixH* " PREP'~ boll tlpellilll: 

application. 10 be used as a lIig!1 tertiillY level seqllential treatment with. not 

" ill place of PREP'· boJJ op<'niog 

Rank cottOIl 

Oropp High <,oil Illui;tUIC 1!J 0.25 24 10 1 Apply ·1 In 7 dal'S prior In 

OetoJiant Tank Mix ...... "' PI/FP'" boll opening 

I tiSh tertiJity level appliGltioo. To be used as it 

5.equf'ntial trl'i.ltlnent with, not 

" ill place of PREP'~ boll openillg 

, , 

Pre-Conditioner I" tlot, dl)" aboV{' ROOF 213 0.5 12 Apply <1 to 7 days prior 

Defolialion " Caul, abovt65'F 1ir'3 to " to 2 ddoJianl Eohances top (lOP 

defoliation reducillg " deterioration oJ bottom (top R.lllk COttOIl I,,,d I ; 

.. For best pelfolmallce, by glouml or illr ,1pplicatloll, cJIOO~ cqulplnelll and spray vnlilm/.'; that wllIlll~1J11! unilorm (overage 01 foliage and bolls. 

,..,. Prelreatment With Defoliants Prior to PREP" brand Ethephon Bo!! Opening Treatmenl: II the cotton i~ ovelly rank or layiog down in the 

middles and good ~prJy col'erage 01 the bolls with rRLI"~ is dillicult, a pr!'tlealrnenl with defoliallts. will be uselul to improve boll coverage- with 

I'tlt-P'~. Usc dosage hUes of PRrp'~ I NOIOIliellunJ 101 boll ope'ning. Read Jlld I)tJ~el\'e dll appropriate label use directions and ptelOlutiolls 101 tilt: 

de/oliant used . 

... Can use up to lull label hue lor each prodllct, 

•• In (alilOlniil ilod AliZOlla liSt a vnlume oiliu Ie\~ ttlJ.1I S gallons fif'r Mrt' for aefl,,1 "pphr.lllolI;, 

BoH Mflturity 

A boJJ is mallrre when II i~ too hald to be deot('d whf'n sqllccn'd bdwt'co tllllmh ,1nd fingNs, ton hMd tn he 'iJiced with a ~,Jlarp knife, and wilen the 

seed (oat becoilles ligllt brown in cnlor 

Use limitations 

Do not e:xc~d a maximlltn of 2 0 111 l!llicplloll ,)(\1';(' ingrcdiellt per a{r" per yeal Hllougll coillbiuc(] or retleated 11Si:$ 01 any ethephon product:;, 

Boll Opening: 00 not tillik mix PREP'~ lirilnd t thepfloll willi iI dt'5lccant il the cottoo is to hI' ~pindlr h;HYE'..te(L 

Pre-Conditinn 101 lJelliliatioll: 00 not tank mix PREP'~ hrilnd ftliepllon with OC,lCGllltS ulllcss plant dC'Siccatioo is tequired. 00 not me a defoli"nl 

belore the-It'; is ~llffirient m~tule Iltl0PClll"l.l !Julb to plodllc .... tile de,ired 'Iiehl (;ee henerdl IIllonllJliol1 'it'(liOiI on how 10 tC'St lor boll millur]t)'_ 

DO NOT APPLY PREP'~ BRMiO rlttt'PItON It tlAIN IS EXPECTED WI1It1N G tlOH.:\ Rillfll;)1I witliill fi hnll~ of ;)pplfcafion mal' reduce plOduct 

perlormaoc('. 

00 not plaltt tHlother (top Within 30 dar) alter tle:ltmrllL Siliall grillOS plamed f:,\rher thim t month Of IOtercropped with the cotton (fOP 10 whic11 

PREP'~ will be applied Olay only be me.] as W\'t.!l ClOpS aod 01.1)' not be IhHVf'\lerl lor load or frKf I'Rrp'· may cause yellowlng alld grm-'Itli 

inhibition 01 treated slllall Y,fillll}_ 

WHEN TO HARVEST COTTON 

Do Ilot harvest UlttOl1 SOOlter than 7 days allCt a II ratment with t't(I=f"~ brallu Ethel)lloll, 

Observe the Ireated crop and hJfVt'l.t \~hl?fI OptUlllln\ bell opening hi1~ ht'en learhel!, tllO eall~ 1i;>T'ie.t might ledute the futl advantage Qj thf.' 

lIe&tlllt'lit <llId tuo I<ltc a IIJlvest may I('sult in rffitJ{t'f1 Qllilhty alld lo\~ 01 lint wllich wilililnp Imlll tilt: plant 

18 
~--------------------~--~~-~~~ 

~ . 

TOBACCO 

Flup-r",prl Only) 

r. PREP'" ~-~-"Y, 

, w"fi, ";;,:-

t 1/3 SO Use drbp nozlles, (iroose tG (lr OC ,pray tips designed to apply 50·60 gpJ at 3)-40 

Applkation p~i ~rrtl " tractor \peed of B mph. U" 

:2 110lZle~ per row; olle on each side of the row dropp('(/ Irrl\' eoough In direct tire 

spray to the Il'ave~ to he ripened and harvested, Thorough spray coverJge is 

csselltial. With a directed spray, be \Urc to harvest all Icave~ with 20% or mOle 

" , u,,'~ '"~~ lop t1!3 22,13 <0 Treal only wlien Iraves rernailting on the stalk dte OIilture To en~lIre remaining , leaves are mature, te~t \pray several tubacfO plants as desuilreu Hodef the section 

"Proper Time of Tredtntent." lise the lower rak in a normally mature (fOP when 

t'xrcriCf1CC indiciltes thallOiniOlUIO ripening inducement i~ required. Use the higher 

r<lle when the crop is heavy and lIa~ a tendency to be rnore fank or when 

tempe-ratures are lower than normal. Always test spray to determirre- if the tobacco is 

rlliltJlle enouglr t(l re~pond 10 Ireatment witlr PRfI'''' 

Apply ovcHhe-tup PRH"" spray as a line mist u~irr& three nonks (one- lIonl!.' trps 

O'ier the CeirtN 01 the plant. and one un eacll side} so all leavcs are covered 

thnrollghly, similar 10 I , Ir"nero nl sy,te-mic '>trckN (ontrol agents. Use I , ,140 '0 GO p;, 

USE LIMITATIONS 

Ou not apply PRrr'~ brand Eth!.'phon to intmalure lei\v('S a\ tlli, (an rM1l1t in un~trsf~ctory (olnring. weight loss and reduced leal quality. 

00 not allow the (fOP t(l over ripen in the lidr/ alter Ir;iltg PRfP'~ brarrd tthr.pllOn, ~ince- this may cau~(' .,nlue reduction in yield and qualrty, 

Do not treat befure- antiLipate<.l major ~torm which lOuld prevent I raNest and re\ul! In crop lo~~. 

00 NOl AI'PlY PREP'~ BRAND HHEPttON tF fV\IN tS EXI'EGW WITtIiN 6 HOURS, fulinl.)11 wittrin 6 hour~ of appli(ation may reduce product 

perlormimec. 

00 not uS/! PRfP'" br(lnd Ethephon with additive~ other tlr,ln rewf1\mend('(! OH thIS label. 

00 not plant another crop within 30 days aft('f tr('JlmerrL 

Do not e;;(Cftl a rrtaxnnurn 01 Jibs etlrcpllon ,1Cflve ingledient trer ,>.cre pN year throngh repeated use, ul arry e-t1lephon prudud~. 

APPLICATION TIMING 

Suuessful r~ults witlr PI!EP'~ brand Etheplron GIll for tre-atmerrt r.i1enlcw.'eo, are matwe, nnt overly rank green wlren sprayed. lu easily deterrnrrle tire 

proper trealment tilhins Jud the uumher of leil'lt:s per stJlk re-ady for hilrves\. test ~pray :;cveml plant~ in m()1e than 0111' IO{iJtion in ("ilCir field ilnd 

observe the re.ponse. Matnre leav{'~ will beRin to ycllow irr 24 to 72 Im,urs, Te~t leaW'\ tlrat fail to yellow rn 72 huurs Me not mature and art' not readi' l1li1 PRfl"M tre,ltmen!. W.lit a If'll.> rJays to ptrm'll lurthN 113frrrill maturrng. tht'H rn~k!.' anolher test ~pray or "InatlJr'lty" cherk. 

.. avoid quality 10\5 and ur po,~ible- leal drop, Irarvc~t any yellowed le~ve~ prior to applir;}tiurr tN~ 10WN rates under rnost cunditiom. limit Uk of 

higher rate~ to (001 ihdow 65f ilt tile time of !reiltrrrt;ut) ~Iow rqrCtilng lbtlditiorr~_ 

Wiren you !rave confirmed the de~ired rrumilfr (Jlleavl'~ per plant that WIll tol!)r, yorr edH rll!lerwiH<" til(' r!limber nl au", ro treat iu Older to fill tire 

harn. 

Prepare your tC'St spr,ll' by ulixillg (Jrrl' tea~poon 01 PR[\,'v brand Ethf'ldron nr 1 quart 01 water. Spray each le\t pl,lnt wrth alJoul t UL of this mlxturt'. 

covering alileav{'5 witlr a !rne mist PREP'" will not tulor rmrnatlH(' 5pmyed Il'a~e~_ 

19 
r 

•• WHEN TO HARVEST 

An filature, spril\'cd [e<lves win lregin 10 (olur within 24 \0 i2 hllurs after PREP'~ brand Ethepholl <lfrpli(,llion. The )'el[owing protl:$$ is weat/ler 

dt'penden!; (001 weather will d('lay. while hUI, SUliny w(';jIlIN (an ~p('ed III r the process. f-lafY('Sltf('<l\eTI IOMC(t) whc[I [caw'S have reJthed fhe desired 

wlor intenSity, 

Ildr.'est can tOmmCf1{C 48 hours '111C'r I'Rr!"~ brand f)lIcpllull ;Jppli(dIIOlf. 10 IlclNlnine holrYeSllimiliS Jml avoid qUillity loss ur ledl drop, clo-.ely 

monitor tre<lled crop and weather (oDditions 

CURING PREP'" BRAND ETttEP/lON TREATED TOBACCO 

Curing procedures ilrc ii, mirth ;111 art as a science dnd each (Ufe nlUst be iudgetl on the basis o[ tobacco conditiun, interval betv.'een trealmenl and 

harvest, weather and type 01 (uring t<I(ility helole pre>(IIPtion tempcrdture and ~enfilillion s<hedub Gin be e~tablished. fo obtain milximum quality, 

(are must be taken to obwrve and (ootrol the (IInng protes, dosely, !'Specially (hlrillg the Idte "(oloring" and early "drying" stages 01 the leal. 

PREP'~ ur,md tlhepllon treated tubatto will have ~tdrtcd the (l)loring fITQ(ess when hiuve~ted, reducing the time required in the coloring phase 01 

(uring. Treated tobacco should be dfled la~ter illohacco leaves;ue greell Of wntalll some greelt when harvested, it may be necessary 10 (olor diem 

lor a lew hOllrs. tl the len'lM: arc complelely yellow. temperature and 'fentil,1tion Iflust be adi!l~ted In il Illilflner to dry the lobacco a~ fast as po~~blc 

witlrollt scalding. Once Ih(' leal i, dried (J!4 dryi. ylln should lollul\' nOfilial piocelilfr,,", lor ((Iring. Sinre PllfP\~ 1(eated leave, (tlfe laster, treated alld 

Ilfitreated leaves should not be lUred together in the '><:Ime biJrn 

IMPORTANT: READ BEFORE USE 

Read Ihe entire Dire(tlOos lor U~C, Conriitlom, Oisctilinler of Warr<lnlics ,md I imifallOn> 01 Liability bl'lore using this product. If terms are nut 

aW',-ptablc, return the1lnopcnet.i prodlltl contalfl('r at onr.'! . 

• u~ing tills prodl rC!, Ils('r UI boyer ilW~plS the Ifillowing Conrlitiolls, fMdalmel of Warr;rnties and Limit."Jtions of liilUility. 

WlNDITIONS: 1h(' rlir('(tiom lor IN: ollhis prndllC! arf' !Jeli('ved to be adeqllale ,mel should be loll owed carefull,'. However, it is impos,ible to t'hminate 

all risks a~~ci,:lIed with Iht' use 011 his plOdlfct (rop milff)" ioelle(tivelle>s or other linin tended (OllscCjllences may result utXau.se of such laClors as 

weather conditions. prescn(e [II ollwr malerials, or tile IrlillWer of use I)r ilpplic<wt!ll, an 01 whidl are be)'olld tht' control 01 Aventis CropScience. All 

such risks shan be ils.5umed by the user or buyt'1-

DISCLAIMER OF WARRANTIES: ,\VENTIS (ROI'5(11 Net MAKES NO OIHlR WARRANTII \ EXPR[:.5 01{ IMl'lIW, Ot· MflKHANTADlllTY OR Of mN~~S toR II 

PARTICUL-\R PURPOSE OR on IERWISf, THAT [X tEND Bt YOr.1) 11IE 51 ATf MEN IS MAD[ 0'\1 (HtS tADEL No agent 01 Avt!ntls CropSCience i~ allthorized to 

Irtake any vlarranties be)·olld thoSf' (ontaint'tl heJeili or to modify the warranties lOnlained herern, AVt NTIS CROI>S(tEN(f DISCLAIMS ANY t lABILITY 

WIi.>\lSOEVER FOR SI'EmL II">ClO!:NTAL OR CONS[QU[Nl tM DAMAG!:S RfSUI tlNG fROM TttE liSE OR HANDliNG or TtliS PRODUCT. 

LIMITATIONS OF LIABILITY: THE tX(lUSIV[ RfMEDY OF IHi US[I( OR BUYER tOR ,\NY AND All toS51:S. INJURIES OR DAlvlAGES RlSU!TING FROM TltE U~E 

OR HANDUNG OF TillS PRODUCT, WH[THI R tN CONTRACT, WARR,-\NTY, TORT, NfC,UGU-.'C[, STRICT lIABtliTY OR OTHERWtSE, SHAll r-iOT EXCEED IHr. 

PURCHASE PRtCE PAID, OR 1\1 AVCNTI!> CRDPS(tENCf'$ ELECTiON, TIll R[PtArEf...1I NT or PRODUCT 

• 

IDtF alld (,uthioll are registered trddelnarb ot Bdy\'f AG, (,trroany 

10ropp <lnd Ginstar are rrgbterrd tradeillarks ami Ultra is a traoem;lfk 01 Agr! \"0 

JHalYildc is a registered trddemark cf Uniroyal Cumpally. 

4Malathion is a trademilrk 01 Ameri(an CyanJmid Coropall)' 

Aventis (ropSdeoce 

P.O. Box 12D14, 2 T.W. Alexander Drive 

Research Triangle Park. North Ca(olina 27709 

I'RFt> is the trddemar~ ulille Avellti, Group, 

t OU';': is a wgiSIt:'fet/ trademark 01 the Avellti, Group 

PR[I'''' brand Ethephnn for (oUon and TouJ(w {Pt NOINGJ Sublnlf\rd 7/17/02 

20 
I 

, 

TM PREP brand Ethephon FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Et!lcpllon (2-Chloroethvl) phmphoni( ilcid'" 

INERT IN6REDIENTS: _ ...... " .. ,. , ....... , ........ 44.6% 

"'litis prodtlO (ontain<. 6 POtlllds elflcpilofl per gJllolL 

EPA Reg. No. 264-418 EPA Est. No. 264-PA-01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO ~ 11~I('d 110 ("lltltlllle 1,1 etj41~t,), hll;queil illguifll P;-1I<l (111e se la ~xpljque <lllstcd eo del",II",. 

III )'OU do flOt IIfldmtilfld tilt' I,lbel. lind ~(lmO:llne to eXrl,lin it to you in del ail ) 

for ~'£Q!'QL And LRANSPORTATION Emergencies Q.NlY (al! 24 Hours A Day 1-aO()..334·7577 

use 01 Illis proriliO lor a ~'Jnely 01 plJllt gOl .... 11I legll!atioll us~ Me pfrJlt'ttC{1 IIV United Stille,> dod loreign lIalelll~ illdudillg 

V.s. Patcnt-t,2'IO,S19, NO li{('rISt' is gr<lIl1~rllu U'ie IIlis plOrllicl ill (01lItiril'5 olher Ihanlh(' Uniled Sialc, 01 for an~' 11\(' filii crlntl'mplall'rl hy Ihl\ I .. hel 

I ["bilil}, {(If palen I illtnflgefllenl Inai' result frOll1 II~ or 'WI(' olllll~ produet Ollbi(lf' II Ie Uniled Slal(-,. 

S ",tk5 !<V""'/' ~Ccl ;-F-, 

• 

• .' . · .. 

•• • ••• 

• • • ·Per- r R·Nct-~ ~ 

lhis 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

(ORROI,IV(. (au'\ts Irrl"'.'l'(lii)lr eye dilmage alld skilliJOIII$. 11;Jr(lIful il swallVl~rd nr ,1\),Olbcillliwlfgli ~Iall Do nO! get in ('\"1'S. 011 ,\(11) or 011 dodlillg. 

PERSONAL PROTEGIVEEQUIPMENT(PPE) ",,-.l<- of ~~y w,j-"",~~of> 'J 

{, ~...j-~,~ ,\pplitalors .. lid olllt:r h,lIldlers mll~1 WI:,'lf (over,ills over ~j(oll·skn('d $lii[l<, ;lIld ,lion pallts, (/1('1111(;11 rf'~"lanl gloves Isuch as Nllrile, Hillyl, Neojln.'lIe 

and/or B<lujf'[ lamlliat('). (hl'llIlcal·reml<lnl footwear pillS $nd.s, prol(,{live erelVl'ar, {h(,flll[al·r\'~i51<iflt lIeadgl'ar lor QVl'rllI'al1 expOiUH' .1lld (hem'lealn",istant aproll whell cleilililig eqllipment or mixing and !oJd!ng 

Ois(dru dothill); lind Oilier absorbellt Ilialerials Illill hasc bel'li drClirhed or lieavily lOlltanlill<lle<il'lltll Ihis plOrlUCh tOflccntrali:' 1)0 not rell~ llieln, 

Follow milllilladllrel'~ IIlstl urllf)f1~ lor dl"ililllIgim.ljnl,linlll}; ?I'r II 00 \1 Kh III~trll( lions lor \>"as!iabk~. IISI'" delerg"lIt ilfld hot ""<lIN Keep <lnd lVd~1i 

PPE ':>I'parately from other I .. lllldl)' 

Wht'nIMndlt'ls 1I'>t clo«>tl \~.,tenl\, fndosed railS. m ')Ir(ralt Ill" UI<lnIiN that IlIeCI$llic reqlllftrllenlS Ii~ted In til!! WOI/.;Cf Pllltet.li,.lIl ~tamlillrl (WI'S) 

for ilgrinrllliralll<!SlKidl's [·W (HI. ) 702-10 (ill (Hi.\). llir hJfldlcr I'PE r('qllirunef1t5 mJv he reduc('d or nloddled J~ spetilied in Ille WI'S 

21 

y 

.._-----------
• 

User Safety Recommendations 

Uscn s/loilid waS!1 hands before cillillX. drinking. <-heY"ing gUill, using I(1Uil(fO or IJsing the toileL 

Vwr\ shOilld 1('lnuve (iutiling illllll~idt{'ly il pesticide gl'\\ Imide. 1111'11 wash body 1I1orollghJy and put 011 <.1('<11] <lotilillg. 

U~('fS ,hould remuve l'pr immedi,ll('ly i1Jter hitmlling tlll~ Plol!lI(.1. ,\\ SUOII a$llo~SlbJe, \vil~1l1hOlouglil~' imd rJlaoge inlu dt'.lll cluthing WJ\h the 

IJut,lr!c oj glo~"'> helm .. rf'mU~l!lg. 

ENVIRONMENTAL HAZARDS 

Du nol J[lply directly to wilt("r, lJr 10 Jr~il\ wiwlr $1111.)(' Willer h fuewllt or to inl('rtirl,lj <11<'01, helow the loe,m higll Wdter Illilrk Do not LQrltolminille 

\','"Iel \~Jlell disposing oj equiplllenl Vi,gllw<lters. 

Do not (Onlalllill;Jt(' w;1Iel IIY'{\ lur Iffigatioll or rlollw,ti( !ltlqMJ><',. 

SPRAY DRIFT 

i\~'oid spray dnlL Uo not <lfJ[Jl~ wlielllVeilUIl,r colldltllln5 mill' «IU\.C drilL Do uot allow this prcrllltt to drill 1m to rtlln·targel ,HeJ$ Dllll may result in 

iUcgal residue~ or illiliry tn <Illi,ltellt U OP\ alld ~-rgetation, III thl~ lorrn 01 leal yelluwing ilnrJ ddoli,11illll, 10 aVrJilJ spr,lY doll. 00 NOI appl)' <lellilJiy 

when willd sp~~d is gredtel Illan to nlph or lillring 1l('1 iods ul ternperatllre In.t'mom. U<.e- oJ larger dropkt ~i7e 1'0111 "bo reUlite ~pr~~' drift. 

AVOIDING 'lPRAY DRIfT Allllf I\l't"ll(!\TlON stfr IS WE I{E'lpO"I'llllllt fY Ot HH Al'PLKAlOR_ 

1 he interaction ul 1Il,IIly ('{jlliplnellhlnd v.t'dtheHt'lolteilla(tors determine lhe potentl<11 lor ~rilV t!rilt llll! Jppli(iltor h responsihle IIlI runsrrleriog 

JII lhe.e tJ(\OI~ wbell milKlllg ti..ci\ions 

rhe lollowing dolt Inan,lgernent reljllirernents musl be 10110'1.'('11 to JHIIII iJll lJrgd 1110l'erlll"111 110m aelial <lppliUlIiolis to Jgrilullural hl'ld OUj1\, 

.dIII/il.leY.:' r('qu~'renwllts du not apply tu lorestry ,rppir(,ltrolls, pllbli( IlfdItIIU$.e'~,or to irpplicatiulI, lISi.n1\ dlY lorlllillatiolls, 

• TII("ulst"nt/.' 01 tile ollkr must nlJlllcs 1)11 the bUNII IfllJSt Illlt e;o:cct'd 1,4 tIll' ienglll of tlrewllIg\p<lll ur lolllr_ 

2 NoalM I11llst ah~<I~) pI lint Thlckw,lnl p,llillid Volt!! lIle ilir ,1I('anl ami ne\,1'( 11(' pointed drJI~m~ilrtJs nlOre tllall 45 Ilegrces_ 

Where stales h~vl' 1110re striogent rcglliations, th~' IhoulJ be oihrr.'i'tl 

rhe ,1pplkatnr '>llould h(" ianilliar willi <lnt! tdk 11110 ,'t(ounl the Inlorillatiun (OY(~I("I) ill tire "elial Dr ilt Reductloll ,\d\'r50I)' Ilelow. 

AERIAL DRIFT REDUCTION ADVISORY 

[Tlli\ s,e(tion is ildYIWty ill n~tlJrr ,Iod does uol ,upersede tire rndlUJatory !,Jbd rcqullcrucllbj. 

INfORMATION ON DROPLET StZE 

1I1e rno,t cJJrttivt' \\"lY to ICUU(C dlill vOlcnlrall) h! apply largf ur{)pl('t~ Tile be\t dlilt Illiloilgement strJ.leg~ i, tu appl)' the klrgesl droplets lh:Jt 

provide suJJiricnt (Overa}\e <rlld cootroL ApoP!Ylllg lalger droplet) relllJu."" drift powillial, but \'>iJJ nut prevent dlilt il ,lllpliutiulis ;lIi~ Qlade ilnplopt'rJy, 

ur unlier fIIlhrvorable eO\1ronrtlentill conul1ri)ns (Sel' wilirL lCIIlIJI.'rJlure ilild llumidlly. illid ferlljJ('ratlile lnv("r'iion\j , 

CONTROLliNG DRDPLfT SIZE 

Volunl{" Use high 1I0w r,lIe lIu7.des to apply tll~ illglle\t prattleJI SJlI.)), HJIIJme NmAc\ with highcr I,lled IIml'\ prorJ,ute lalger dro[lleh. 

I'rC'>sule • Do not exr:cfd tire nnole IIldlllllaOlirer's ICU)!I1/l!endHi ilre%Urcs FlJr 111,111',' nUl/Ie t"(lle'> hrWI~r pleSSllre prodw,<":S larger dropll!h, Wilen 

Iligher tlow rales i'I/(' rtN:deri, rl}{' Iligher JlOI~ r Jte 1111ll!/.'\ instead 01 irICrtminit llr(,~sllr('. 

ember 01 nunlc\· Use the lIlilillhlJnl nllmber 01 nullleL lhM provid~ \IIlriufln (Overage, .' , 

Nook 01 ientilliun • Odenl'lng n07l1~ St; tllal lhe ~pra\' IS released p~rirUcJ 10 Ule Jirs\re;-Hn ploduCt's IJrgl'r dloplets tllan allicr orientaliolls Jnd i\ tll(" 

r('wmnltlldeu priJcti(' ~il!llrikiint ddlenrnn (uolm hOlil1lllt,ll \\'ill w(j(Ke dloplet we and ioueasc llriJt fXltentiJI. 

~unle Yype· use " lIo111e 1)'fH' lir"t rS rlesignl'd lor the ilmndNj ,'Prlicdt!!)!l Wltll II1ml nUllle tV[-ll'S, narruwer sprJ), angles proullct:' largtr droplets 

(ollsider Iising luw·rJr rJ In()lll('~. '>ollu \tledll! 1I0lLle~ DrielHed ~t[,jigllt had; proflu«(' lIlC IJrgcst dlopl!"h and tilt' luwcst dlill. 

BOOM UNGTH 

For Wille use patli'rIl5, rftillLIlIg ttle f'1I"OIvt: boum length 10 leIS lhan 3}4 01 lite l\'illg~PJII or rotl)l 1r1l£lh IllilV IUlth('r l<'dllc(' drill wiliiont retillLing 

swalh \ ... ·idth. 

APPLICATION HEIGllT 

.o\PPlicatiolls slluulu not be milrlc ,It d 11l'I1\hl gre"ltr thiJn 10 Iet:t JIJOH' the lop (II the tJlgel plants unless J gredtel helgln I~ rerplired fllr aimillt "-<lIe\\, 

M,ddng aprli(iltiolls at the luwest hClg!111hill I, <,cife reduces expO\\III' ,11 dropl!"ts 10 E\'<Ipt'lr,)tioll Jnd willd_ ' 

SWATH ADJUSTMENT 

Wilen apprlf,1tioll~ M!" I11Jril' witlr ,I OO~I~'lIlrJ. Hie 5\1'a{1r I~rll h(' dl\[1l:lreu downwilld. lllt'leloll~. ull tilt' IJr ,lnrJ Ilol'tnwind edges 01 lht Helrl, tile 

applil,dtlJr ~hrl!llu \OUIIWI1",'to: lur thi~ Ilrwl;rCf'llWnl by ,1d[lrSting tl1l' p,lth of lhl' airuall IJPWlllrJ Sw,lth adju\tll1t'nt dlstall(e ,IIOuhllll(H'aY.::. Witil 

inaeasillg drill jlOl(,!ltiJI 1.1liglll:r Willd, "lllalier drops. etr.) " 

WINO 

Dlift pnt('lItfill is lnw{"\t h(,h\'(-cn winrl \pet!(h 01 2 . 10 mph llllIU'VI':'f< IIMOy f,l(\{)(\, !Il(\lldUIB droplet Sill.' dnd L'ijlJlplnerlt f\'pe ul'tenl1ille dlill 

poti.:ntial at any Riven sfX:!.'d, .>\pph(atinrl ~hmllu Il\' .l\'oldro below 2. lTllib rloe til v,JIIJhlc 'hind IlirN.tion iind Iligll illn'rsion potelltlal N011-' total 

terrain Gill inUucll(l: winrl p<ltlenlS E;-ery ,Wp\rCiltor sl!Orlhl bto 1<111111"11 wi;-h !u(al wind patterll, JmI how lhey JJlect srllay drift, 

22 
TEMPERATURE AND HUMIDITY 

WIIt'llllIaking a/1J1licalion~ il1ln1'; rd,lIive hurllidlly, sel up equiplIl(.'n1 10 product' IJrgt'! dropl~g 10 COlilperlSJle lor l'\·,ll){Jl,llion. Oroplel t'vJpor,llI011 

i~ Inn~1 sev~re \'Illcn (Onllilinn~ arc bnl11 1101 illlil Ihy 

TEMPERATURE INVERS1DNS 

Applicajion~ ~llolllri nol occur ullring" leiliperdlure invenioll ba;]usr Uilit palelllial is hlgll lcmpCldlur\' il1\'cr~lons 1 eWilt vt'rticJI air olixlllg. l~llItll 

r<lUses :.mall sll~pcl1uCd dl OrielS 10 It'm;)in ill ,1 lOncelllr;11ed clUild. This dllud riln move ill uflprf!{/iclaole Ilir('(11U1I) uuC' to Ihe Ilghl variable wind~ 

conlOiOl1 dllrillg jrl'icr~ions. TC[llller'l10r(· invt"r\ion\ are (iIJrdCleriLcd o~ in((('J~ing lemJlerillurts wilh al11111ue ailU Me cnnllnOil on IllShls will I limilell 

rloud cover and lighllo 110 Willd, fhey bcgil110 lorm as llit 11111 seh and often (fJ111ifl1JC 11110 Ihe morn log. Their pr('Y!flCC rilll be indi(')H'd by ground 

log, IlOwcver, il foa is IlOt preWlll. il1w(siOils (all al$O oe irlelilirll>d hi' lhe 1110\'(:I1)('rll 01 Ill1nl:C fl0ill" gl()und wurre or <111 aircral1 smoke gtnrr<lI01 

5ulOke IhJl lai'ers illl(ll11oVCS IJ1Naily ill " ((i1l1;t!lllr,lled rlIIIIU (IIndrr low WiIiU rnlluiliol15! illdil:(Jles Jil il1\'N~iol1, while Imok(' 111.11 nlOVe'S upward Jnd 

r,lllidli' llissipdle~ in(lic;lIc~ goorl H:r1ilal air nuxill!:!. 

SENSITIVE AREAS 

1 lie l}('sliliue 5liol11d (lilly be applied 1\'11<:'1] lh~ pOlentlal k,r (/1 ifll0 ,)djacenl sellslli..-!! Me'}s (e.g. residellll,ll drea~, bullies III watel. kllowllildllilJl lor 

IlueJl~l1t'd Ilr emJangerel1 ~PetiC5. fl0I1-I;l1g('1 1I0p~) il 1Illllirna\ [e.g, wilen wiml is blowillg ,1\~ay 1101111 he sellsilive ilrf~as1. 

USE PRECAUTIONS 

Do no! JPply PRFP'" IIri!ml Ethepllull for (oHoll ;Hld Tuoa(( u thmugh Jnv Iype 01 ifflt\<lliull s'r,ICIll. 

Avoid ~pray drilt 10 Ileill by crop~ ,)S lhis ploollrl will C<)II\.C mmjilil.allolls il]I11al11 ~rm~lh, Planl injl1ry or redllted Yield,> will resulL 

1>lix only lhe ,lmOllill 01 ,prav ~Oll ('xpccllo IIW e<illl day 001101 ililow mixed solul11l1110 \Idllrl o\'{'rlliRhl, 

• DIRECTIONS FOR USE 

It isa violation of Federal law 10 u~ lhis producl in a manner inconsistent wilh its labeling, 

Do not apply lhis ptoduct in a way lhat will contact workers at ollter pc(sons, either diredly or th(ough drill. Only prot&led handle(s may be in 

th(' area duting application. For any requirements specific 10 your Stale or T dbe, consult the agency responsible for peslicide regulations.. 

Read entire label bcfole using this product. 

Ule Ihis producl only in ,p'-(I1rUd01 e with ils IJbf'lilig ;lIIU \~ilh Ille Worker Proleclil1l1 St.1l1daru, ·tl1 CFR pan 170 Thi\ SI,lllrlilnl cOlll<1in\ rt'i\lIirCmelll~ 

lor Ihe proluliofl 01 agliculll1ral work{'f, ilil fanllS. 10(eslS, lIufs('ries, and \tr('t'lihOIl*S, ;;nd lIiI01I1.;r~ 0\ agriwltural !leslicide~, It cnllla,"~ 

II lor 1Iililliog, dewnlalllinallOn, nOlill(Jllon, ;]IIU ('IIiCIgeIlC}, ,:I~'ii~lancf'. 11 Jlw WllIalllS ~pe(ifi( 1Il~III1ClioI11 ,llld exceplions pertililling 10 

I 11 (111 111I~ label aboul perwnillllroll,{live P,{juitlment (I'Pl). nOli!lcal Kill lIJ worker,> ,1110 restll(,I('/I'elllIY ililervdls TIl{' reqllircmelll~ ill 11(1'0; 

only apply 101M'S 011 hi~ PI OduLt lh,H <lrt' covererl by 111e WlJrh'r Prolectlun Slal1l11rri, 

nol enler or allow ~~OIkcr efllry in!n IltJled ilrc,1S durifl\t Ih~ 11?511 iCh'fi·eotr'y inler";lll.RI I) \,1 'IB hl)IIIS. fhe REI !~ 7 2 ht!{If~ III JredS wllere """g' I 

I I is Ics'> lhal125 inchK per \".'Jr 

(equirNilor early el]lry 10 lr~alt"{1 arl'iI~ 1I1dll~ 11l'll1lil1t'd llnder the Workcr l'roll'l!ion Sland<>rd "lid Illal ~. ~'~:i:,~~~~~§§~~~:;l:1 II~aled ~lIlll il~ plJnll, wil or water is co,NaliS o~er 10flg.~lccvecl shirl {IOU lflilil P(IIIIS, tlicmi(al rcsi~lalll I 

I resi\tanl lootwear plu~ >;(1Ck;, ,:Inrl prolccllve eyewear. For lI¥crheart expo~url'. (-h<il11ical-ll'5l>tal]l h~ddgear I 

lhl' Ii II II h II '1 

",</'-'~L 

I 

b rvt-t--~ ~ ..l I} V\-"~'4:..-.-/ 

23 
--------------.. ----~ 

STORAGE AND DISPOSAL 

nut (onldlllilltltL' WdIN, loor!, or ked by snrrag~ or di'po<;J1. 

If conlaliler is brokell or Lonrerrts haw' Ipiilelt loUu\\' JII precanliDns indk<Jled <lbnve <lltl! (k,jI) lilt immcdiatdy, Iklnrc de~nrny; rip, PHI lin frrll length 

\wust'rs,. long sleeved shirl, prole(tlve glov('$, dOO goggles or IMe ~hjeJd. wilk up ~pil! with ,rOSOruCnI rnerli.! suLi, ,1'. ~H1d. Nlth nr other srritable 

materia! ~nd rlispo\(' 01 waste at ,111 aPlrlO\'f'rj !'i,nll'di"t)<)<;;ll l,lrilltv 

PESTIODf DISPOSAL 

l'e~lind(' \'J.),te$ alt' iJcult'ly lIol7drdoll$ Irnprllpcr rlisp(l~J oj l')((l'~S pe~ti(Urc. WI"y Ini~tIJrL'. Irr rin\Jte j~ a vioiatlull of fctier,ll Jaw II 'h,,,, ",,,d 

be di~llo'>f'd of by 11'£ ,1nurr1UIY. \0 I,dwl IIrstru((joll~. (orn;H\ yO(l[ S'd\(, I'e,\irjilc or Environlllcnral (ontrol A!!~'I\(y or tire ItazaruOlrS Waste 

~~'~~::,"'~' ;~'~" ilt thr 1tC',lle,t fI'." Rewon;d Offiu' [fir fllmldw¢ 

DISPOSAL 

(rrr equIValent) tire (-mpt1' wnrainel\. Theil oller frrl req'dllrg or rcc(lfluitinning, or prrnctur~ ,lilt! rli;pow of ilt a <.-lnit'rrl' IJlldliH, or by 

~~~~;;~:~~Eor-'~::":~~ Ul' stall' ,)IIUIO( dJ JllllrQlrti1..'S. hy burtllng If COOt,111Ie( i\ burned, \tay out oj ~ll1oke -- REFIllABLE CONTAINERS 

use. rellirn Ihe CDaldinN 10 (Itt' POII\I oj pur(lIase 01 designated lueJ(iuns. Ihj~ LOnMroer rnust unJ~' be relilled With PREP'" brand Illrcphun fur 

<ltld fobalLo. 1)0 ~OT RrUSr rHt (ONtAIN!R FOR .'\NY 011RR t'LRPO~E Prinr to relrlling, rn,pw tJrornuglrly for ddmorgl' Sllch <1\ 

dbra)jon~ Jnd ilJmaged nl ",!)III out t!uedUS till d/)~ule tlcvi(('5 Do not rdill or IraMpult d,rrl1aged or Icaking (fJO\airrl'r5 (jrerk lor 

Ii "I - II 1.lIthL'CVrrlalof'r' rl.l II,rCl\)lnirtdthel II r 

~ENI,RAlINFORMATION 

conON 

A foli,lr ,pray 01 PREP'" h~fld I.tlrcphrm for Cott0n ;'IIId 1nl1<lt({t will iI(reicr<l:(' OW'lring ul i1rdllrlt' llrropencrilollrrrr b()l1~ amf enllJncl:' dcfoli,1lrorr 

whirh C,)n resull In earlier haIVcst With dn Il!uc.neu re(Ovrr.rbl(' ~ir:J1l PRfP" \r('<1Iorcnt url mt\on Jllor.i inol'ilst;d efJiuenry hOlll il orrcC' OI.1:r 

hilr\'tSI. 

TOBACCO (flUE-CURED)" A foliar sway of PRlI"u hr,lrrti lthcplroll prumolts !\lrJy. rrnlforrn "yellowillg" nl rll,lll11e tou,lew. PRI P'~ re;jrr(<,~ (Urlrlg time, / 

allOWing more dlicr('nt use 01 luring b~fIl Sp;rL('. ,'Hit! irrLlea~'l1 corrtrol over iraIH'\t sdredtlle" 

SPRAY PREPARATION .lk ttr\7,:;!,: ' ~. ~'_ / j0W'.d 

,''.dd '1i2 tu 3.14 uf the re-quih:fl JInOurrl 01 w,ller tn rile \prJ'f tJnle StMt ,181101.1Iorl. Adrl the- required ;JI1lollrrl orpREP'~ brand_ttlrephrm:-aot! the ~~~~,-,~ 

remaining aOr(Jlrrr[ of WJt('L Prr[MrC' only a~ Inndr wrily soilltion dS Cilll be r)\ed orr Ihe rlay III miXing, Do nllt allow Iplir)' solntioo Iu Slilrrd overnight. 

Do 1101 spill the «(lnrt'lltralL'd prurirllt on \pray e((rllplrrent, or ,1rry ,wpIJor' part~, 

ANY SPtltS SHOULD BE RthSm IM\jtt)IAIII Y \','1 tH Pt I,NiY OF WA1(R 

U~e of a HurS!' t&nk i~ highly r(,{(1rnrnend<"1i for iWOlrling pO;:;lhle spill~ uf (lrr~:fotriltetl 10Jlrrillatlllll orr Wr,li' eqrnprlltllt ur ani' ,1iqrIJnf' pdrts 

TANI\M!XIU1lliS WITH DEfOUANTSAND INSECTICIDES /'~'- -,/1£<' (~,tk"i'4"I·hf"«,,,-<-, 

(_EP'~ ,,£!~,!I EthepllPr) I~ fOlnp,ltiblc with nHI, t OllX'" Dropp', DrO[1p' Utr<l'~!, Ginsr;)r2. ttarv;\de" Methy! P.lfatJrron, Gutlriun\ and Mdlalhi(l1)4 

/_rr""''jnay lie app~ed In \!!qlll'nll' Dr JS ,1 IJrrk rnrx\lrr(' (DO I\OT TANK MIX WIIH 01 <'ICC"NfS II C01IO~ I~ 10 Ol SPINOll ItARVl-STW). Follow ill! 

i~~,~e lise pre(ilutron~ Jrhi rale pL'r arre rrtOOHrrenoa\IOn\ on Iilbeb 01 PI{Jdun~ applll'd as laok mixlures ur in ~qrJeIK(' rvrth 1'1fE~ \ t-/ 

!~,- (tmeel!,?a:' In \.Olne (JSl:S ~Ji)\ht rl'(hl(liull 10 boll up('ning respoll~ IrJ~ heelr obY:rw~d r'ilrerr lank rnixt'S I\'rll r defnli"nt5 were used ~~'-.•• 

/ 

V 

l\N., Good agitation irr the ~prily t')nl: i,<,s\('lItial Jlld') tank IlhXhrrc ~hultld rrot he allowed to 5.1i1nt! wltlr0ut agitalion for rliort': th,)n S to 10 minlrles ReJd 

..;!' <urd ob*rve JIJ ,1pprOprrJle l;rue! lI~l' rJlrectrDrr~ (Iod PI e(Juti()-lI~ lor tire rlelolianb and 1'IlSf'{trcid~-'JI5ed, I, ,,&l~¥ " ••.. ' .. ,,"" '~~""'-.''-i'h·, <fA\. ft."""J-'_ " 

," NOTE: U~I)ER ct ttrAiN CO"JDITIONS-. T,\NK \ltXitll£S Ot(PRrr''' !:lRA',/O IlHU'1I01{Wt1ll DESICCANT'> CONIAI'-lI\G SODIUM (HlORi\T( (OUt D IRSUll 

IN THf I ORMATION OF I tyPOCttLQROUS ,,00'> WHlfll ON IltAT1fIG\VTllTMlrTOXfcCl ttORlm, rUI>lLS, 

OU t\o r MIX t'RfV"-B~'~~D"r~'HEI'I'iO'l'\\'tTf-t ,'I,t!,IONILtI,1 TI-lIO..,Ulr" IE. ..,unl t..\Nt.: r,tlXTUliES MAY RI SUl T tN FOR\IATt{J\ or I UXt( f UMI S. 

EQUtPMfNT CLEANTNC;--··'~"" -'" " - -, / . f <, , q~" ,"',',' '. '7:,;,,,,,, 

Bc(01u~ 01 the ,rLidi( 1I.l\rrre oj tiltS pwcillrt, prolnrlg('1! L'!(pn\Ur(' to ,prdy u"PUSrt will darltdg<' ilU}'irllrlaSlil!>, (Ntdir1 pillrrl\ 'loci m~tals 

Rins{' thoroughly Wllh .l drlers<"rrt ,rrul l\ilttr ,)11 e_WO~\!rl iI<ryJic Irltlsti, I~(jf InilleriJI~ (t'.g , ,lirLiafl n'lr\dll rlelds!. and pJIOtet! Sllr I,lees within an hour 

afkr t'Xfm,ur"10 sprJy df'posit~, 

At the end of each day, rilile thmoughl" wrth a rleter:,:{'rrt <llrll ""ller all th(, rtrtt,11 pJlts rd Ihl' <rlrrrJlt .)(11llllc ;r\50(lated 'PIM ('1lrliprrrellt eXlrO$('(1 to 

11r~ ~1>rilY d~pn;ils 

24 .-.-~--~ .... - .. ----
conON 

USE EXPECTED PREP'" ONE MINIMUM SPRAY AI'PUCATION 

CON[)ITIONS RATE GALLON VOLUMES TIMING 

PREP~TREA (Gals/A)· 

Piot>fA "SA.L ,,~ C,m,mrl Ai,'-

r i 00'"'. . Ilot and dry BU'f (I[ \ 1/3 1.0 b Apply when thl' number ~! 

Boll Opener""" Higlier IIIJIIlrI.' ilrlop<'oed boll, 

SIIII,Clcol 10 prodll(e - II;; Dry illlJ 7'> 10 BtJ"l 2 15 , 

'" 1 desm'd crop See !lelow lor h~il 

un 2.0 J 0' holl nI,illirily. Irc~lmerll (001 hilI ;IDove G)~I ! ~;~~ormIV OIlt'11S holls 7 10 14 m cdrliN. I D~II' '· ... "'1 

j ·':r. roLEX· High wil nrOIStilll' 1:3 025 H 10 S "ppl,,. 4 to 7 day, prior 10 

"' ,. I'REP'~ tJoll ollel1lOg I Tank Mix* .... applicd!iOIL To be lI~d as d Iligh lerlllily kwl 

SN)tu.'llliJI Irealrllcnl with, 110\ m I i~ ;;I~(~·~I PRI,'" boll opelling 

,~~ I Halik (OUOII , , , 

lIigh <.nil rIlOI\\Oll' 

,) 111 

(Il'} j~ 10 l ! ',;~i~~~ 4 10 7 uavs prior 10 

Tank Mi~"** , j)f _ .J; I; hall oj}{'llillg 

'lppli(Jtll)n, loll!' use-Ii ,IS ;j IliKi! lerlilil,! level , j ~qul'nli.ll tr('~lillcnl \l'ilh, nOI 

01 - In plate 01 I'RfP'~ hOiI opeiling I ,,,' ",II"" " " Pre-Condi\ioner '0; HOI, dry, <lliOl'(' UU'f 213 IL~ 11 Apply 4 10 7 days PliOf t" 

Defoliation (001, doo.,e b5"f I Iii II) & 10 1 dC'ioljilllL trlliancr. top Lrop 

I 

defoliation reducing 01 

Rank (011011 d('teri~ral~Or~r ~~rl~r';~~::l~()P 

... for besl perfOfllliln(e, by ground 01 .Iir JpplIC<lliOII, chrHlsr cQuipmell1 anli ;pr<lv ..olUllles 1I1at I\illlll~ure unllOfrll (GI'er;)!:!!! of lollaw' ami bolls. 

** Pr~treatment Wilh Defoliants Prior to .eR[p~raEA~lhephon Boll o~ening Tr~atment_: IIlht' 1OIIOII ISov('rl~ rank or laying down in I,he ~)- ~~~,<, m ,dd[:s and good ~pr.Jy mvt'rilg~ nl tht" ll1j!ls wllIl(fIRII''::)S dil,h(Uh, il prl'lr.:~'l!nll'lIl wllh defoh'II.1IS '1'111 b", !lSd.','1 III Impmn' boll (I)~'era)\e Wllh t rh"',~ 

~'pmr'~~.) V.-.e dosage r,lte~ ul PRI P ~ rf'{,Olllm!'rl(Je-rl moll oJ}{'nIIlX, R"au and obY'rI'e all <lllprOpndlc lahclllSf' rJlr('(llnrl~ Jnd Ijler;)lliiolls for III(' ) q 

'-(f(:fdliil'rll US<:I"I. '/l?,-",) 

**'" (an I,'>e up 10 hlillabcl f.)le lor Fadl plGlluo e-* In rilliforniil anrl ArilOna USl' a W!lIffie 01 r.o IL":>S Ihilll:; g.)lIo(l~ PN Mrf' lu( aNl,jl ,lpphl..illinm 

Boll Maturity 

A boll i:l Olalurl' whell it i .. 100 hald to Il(:(knled WI'WIl 5qlleeltn belw<'l'n 111I1I11h ,llid III Igel" to.u 11,)rri t,~ he- dKrd Willi ,1 <;llarp knile, ami whl'n Illl' 

wed (oal u{>(Omeslighl Ilrown ill (lkll 

Use Limitations 

Do nul·(-xceed aln;nlmUIII 01 2 (l11; .. r:HI~hnn ;1(11~r illl';rlXlit"111 r><"r ,Ilre [wr year ti1!(lHSb wmhirled or rcp('aled US('~ 01 any e1hephl)l1 prodillb 

Boll Opening: Do nollank Illi(PfU:P'~ brilll~t[theP!lOn with <l dcsirr.,lIllli Ihe 1OilOil is to lie sDindle Iw\'e~lcd '- -~,~-' - ,--~-------

Pr("(,Oiltlilioll lor Oelolialll)ll: On rlu[ \.)nl:: Illi)£l)Rt:p'~ hritiid Ilhcphm I wifh desl«(.)II!S unlM~ p!.)fll dL'Sic(Jllon is rl'quired, 00 oUI t.J<.i' a ddoliallt 

helore Ihere is \t.JIIIC)I:n.LOlil\llre UflOIJ;CfIS'd hilfi$l(i-p;o(i;-;I:e Ihl' dl~ir(.,.j field (~el' Gt'llf'fdllnlorlllannll \C(\101l UII hnw 10 1('\1 tOI boillllJlllrity. 

DO NOT APPLY 5'ilfP'~ IIRANI) nHfl'IIO)t'1I R>\I~ I::' EXI'I-CHD WITIII:-' G IIOLRS R'!infall wilhill r, 110111'> ul "pplicallnll IIlay rcdUCl' product 

/Il.'riofllldl)(e . .-,-.~ " 

00 not plJlI1 <H1ollier (rOP wilhlll 30 rl<tr" .)il«r Ir('~lllIenl. Slllall gr,rlils pldlllM eMIi('r Ihall \ lllOrllh (II interrruPIXit ,~ilh Ihe Lunon (fOp In ..... lIlch 

I'REP'~ will h~ ilpplied lila!' 01111' 1J<: used ,1\ ((}Vcr (1011\ and Inal' nn( bl' hdrVl:')te-<1 lor ffinLi or lee" I'RI r'~ mdy C311W yclloWIIlj\ ilOII growlh 

1IIIIibilirm of Irealed \HlaH grdlns, 

WHEN TO HARVEST COnON 

Do nollldl"y(>S1 Wl\on Y)OON II un 7 ddV'S ,llier ,1 Ire,cltm(,nl \'l~lh I'I{EP'~ hlilll(1 ! Iheph(lrL 

Oh~erv{' Ihe tr<,,{ted (rnp alld harec\1 Il'h!'11 Dplimum holl OP('IlIlI~ hil~ Geen reache·d. Too early hilf',~~\ mlglil n'<ill(c Ihe full adrarlld?;e nf till' 

Irealmenl and Ion l'!le a h;lrl'l'Sf !lldY rt',:~1 III rNluc('d IjUJhlr alld In" (II hr.! l'>'llidll\iU drop hOllllht planl 

25 

,/ 

V 
Directed SprJY 

Appll(,1110n 

0\'c[·1h(',10 11 

"pplir<lhOIl 

--""-----"" 

J In 'in 

I tt, -2m 

TOBACCO 

U5e drup (loale, (hun,!: TG or 0( \pray lips designed, I. SO· 60 S[J<I al 3540 

p~i and ,It tractor ,petti 01 2·3 lurll. lise 

2. nozzle, pt'r lOW, on(' Oil eJeli ~ide oj the HII'! dropped low f'lInugh 10 direct tile 

,pray 10 thl' leilves to lie lipened ,md IIJIVC~I('d, lhnrough spray mWfilgc i, 

f'~'><:'lIli,ll Willi <l dilli(lcd ,pray. Jl'~ ~ure 10 hJlve\1 illl le(lve> willi 20')(; or ((lort' 

[reill Oilly \vhCIl Irav!."> I i on IIle ~talk Me malure. To cmure i i '( 

I(',,~('$ art'" o(illul!;, le,l spray seve[iil tobacco pl,1nl\ <!~ db{ril)ed IInder llie S('(llon 

"Proper rlln(' 01 TreatmellJ" Usc the lower filii:' in a oormally IIIi1ture (rap whell 

expcnCr1(c Indi(~lc~ Ih.31 nlminnlfo ripcning indnfeme{li i, rC(luircri Ihe the IlIgller Ir/ 

[ale i'llit'll tI((' (WP I, IICd~ and In~ <1 1t'lidcl\(Y 10 tit'. Inure rank or wh~n 

1l'llIpNJtllrM Me luwer Ulan nnrll!;11 Always test 'ipray 10 dclernllne d IIH~ lohacco I~ 

") 

matllfl! enough to r~~ umiJo lreatment Wllh I'Uff"~ J "'iC""' 

Applv over Ilie-lofJ REP':.wm.V <1\ a hlle mi,1 1I,In8 Ihle!.' nOlll(,s (onr- 1I0lJle I 

rWN Ihe u!lIlcr 01 llie pldili. Jlld one 011 edcll ,ide) ,0 Jil le'Wb drc coverC'd 

thoroughl')'. ,llIlildl 10 Ihe JppliQliOiI IJJltcrn of ,y,t!'mir ,lId:cr colilrol agenl'>, U:,e 

1060 

:~~~,~~;;b~,;'nn;d.~~'~. :~' ~': imrnalllf<- !!',we, d, lilis(,lll rMulll1\ 11I1'>JII,bcloryrolflrlllj{. I~cigllllo»alid reduced leal qIlJlit)'. 

Do IlOl dllow r ' I ripen in IIII.' IleitJ illier u5inJI;m;'-:f~~l1d ['I'i'I~'~;I:~)lItc Illis roilY (.)llse \I1I!1C rctlurtion in 'iir-Irl ,\lid qUJliw, ""'~~-~.-. 

Do nol Ireal helore Jntlfill'II("I1 Iflaior 5torn I wlnrll rill/id prc\-'('nllmve;1 iJrld r("~ull in (fOp In,~. 

ou NOT <o\PPLl'~'B'RA-~'O-ETtlm)lf ktV~ IS EXPI [III) WITHIN (; 1101111\ I{dinfall wililln h IHlun 01 applicalioll In.W Icdu(c product 

periormance. ~-,~-~.-.. -•.. -~.-

00 1101 u~~'-;"br;(ld EiT\cjlho~~~illl illl(hlII'C, olher 11I.1n rK:lllliOICllded on Ij)h l)lllcL 

I)n IInl pidOI allolher crop \~ithll1 30 days "ller Ir(,<111 neili. 

Do [jot ('XCero)l nljlxilnlllO 01 2 Ibs elhrl1tlllll ,1(11\'C Iligrefllt'nt I)N JW: Ilcr i'far Ihrongh ICIH~Jled OSC\ of illly ,'IIIt'pllOll prodll(I\, 

APPllO.TION TIMING 

~uw:$sful r{',lllt" IVllh~REP'·~b~~- flh;lIoll tdillor Irealml'nl wilen ic,)I"{'S Me malnre, 1\01 ovrrly rank green wllcll ,pr,1'r'NI fo f'.nily tlelcllliloe Iii .. 

proper trcdli'lICnlltllling an 1he-(jU'iI'iber-onb ... r; per ,(Jlk read)' III[ b;II'.'~L lest spr,1y ,\,,\'Njd rridlll; ill 1ll00e Ihan olle IOldlion in each fielrl and 

Ob?l;file.th':Hi"fItlfl\e', Mature leav('", I~ill lJegllllo yellow In £,1 Ifl 72 IlolIIs T0:51 I("N". Ilul l<1illo ytllow in 72 h(lur~ dIe nol matlll!' ilnd dre riOI read)' 

10r~~~e~Hn{'m,-.3Wait a lew dd\',; 10 perm!! fllrther IIJlurill oliltllflng. Ih~n make allOlher I{',I ~llril\, or "11 lahlnl\," (ht><k, 

A amid qualily 10» ,)lId or pO\~lhlt' kdl drop, IIJr\"e~1 ;IIW ')dluwcU Ie,)v('~ prior III d!JPIIC<llion. lise 11)\~er ralc, under 1ll()~1 {{lilflilinfl}. limit lise oi 

~gh('[ rales 10 mol iilelowf,sr <It lilt' Iline nllreallllclll) slow rillenillg WlldillOll}. 

Wilen \'<llrhilve <onlil[lwli IIh' lie',ilen nlJlllb.![ olled"l'\ I)!'( pl;,nt Ihill will (oto)!, '.-"11 Ull d('\~nnlinl' Ih{' IlIlrnhPf of ,1cre~ k' I(Cdl ill oroN jll hilihe 

IMrn ~.- ,''--- --" ____ 'j 

Prep,l.re yOIJf tesl 'Ilidl bi', mi~i~il 0111' ~A~ol I OI\PR£~~ hr~~](!yllep!lo.~.!ill ! qlliifl flf Wdler. ~r,1y filrh 1f',1 p!,Ull willi abOul 1 nz ollhi'i InIXIl;fC. (, / 

ruvcIllIg alileilve5 wllh il filic IIIISI! ·rRtp'~ )\-,1,1 n]}1 2;ior mWI<l\ur(' ,pral'",ill£'J\'c~ '------ -~""'-'" \. 

26 
----~--~. 

WHEN TO HARVEST 

All mature, ~pfilycd ll'aVl:'~ will hegln to (olor \\1111111 2·1 10 72 hOIlf\ ,lite rHfP'~ bral1~e.!l?~i111J1li(alion. Th~ yellowing fJfO(e~S i\ 1'it'i1lher 

depelldelll; ((Jol \H'Jlher IVIII delay, while hoi, SIIIIII,( wCiltlll'f (41\ 5peco nil I 1l' f()(t .... ~. Iiollvrsl Ireilla:!lolMlCO when I('ilves Ila\-e Icarhed the deSlre;J 

WI(H 11IIen~ity_ < '" "----~ 

I'lM\'l'5t [In Wl\1l1lel\(1:' 48 hOllf!> ,1Iter!PRI;P·· bfillid flllI'pllonjappliGllion 

munll(Jr I(MIM crop Jnd weal her (oIHJi~- --~-~,- ~ -- -

10 dtterllHn~ 11~1\·('St timing and ~~'old quality 1(1~~ Of leill drop, rlosely 

CURING PREP'" BRAND ETHEPHON lRfA1ED TOBACCO 

(liring pror.edllics ~fe ,1\ mlflh ilil ,ulas i1 KlCIICf' and eacll (life m(I~1 he IlIdgcrl on tlte IklSi5 olloh,KW (ondllion, 1II1eIVal1ietween Irc,11111('01 Jnll 

Ilap.:I'Sl, v. .... iltll(~r Jnd type 01 (1I(1I1g lao Illy heloll" pft~tfipli(}n leffipt'l<1tllrc illid vemilJtion schedilles (all h~ t5tabll~lIed To obl.)ilt m,jXlmum qualily. 

(arc OIIiSI be laken 1(1 ob\Crve .:inn wnlrol thl' Olflllg prn( es\ tlosel\,. c\pc<iilll~' duriltR lI(e lale "colorillg' and early "drving" slage~ ollhe It·d!. 

; rRli;;':~;;;JE~~~ ceall'iJ 10iJa(W will h,I\'c slalted the 1.010ling prO(~5S ",hell harveslclJ. redu(illg IIle llioe ft"qlllu:d irl Ihe coloring pilau- 01 

wong ft'ille 10 .1(CO ~lIollld b~ dfied lasteL II tohJu() It,wcs are green or contain sonl€' greell wilen lIJ1Vt'\lal. il way be neusSJry 10 colm fhem 

1m a lew houl>, 1I1he le<l\'('\ Jn~ willplelely 'i~1I0\~. telflperatufe and \cntilalioll must be Jdllj~lct1 in J.J1!i!. ler If I dry til(' lobilC(O il~ 1.)~1 as 110ssible 

wililOul ~i)lrlilig. Oncl;' tht" 1('011 i, dficti f3r4 dry), yOU il!()lIld loUow IIOf!ll.i\1 pfoc<,duJc~ {Qr CUfinl-\.~e PRrJ''''' lC{lled Ie-'t\'(!s (ljfe IJsler, If<'.lled Jnd 

tlfllrealed h.',lVbshnulrl fiot llf: cilled lug<"tilcr III the Xlmc O,lrl1 CL-v:'t,t-~<)~ -J0"CV<.->. 1.. 'L I E-b &J A R R ft k! Ti 

JMPORTANT:READ BEFORE USE~M'Jl) D! S CLAL!v\ E. R 'J 

• 

101 ( anri Guillion <If(' rejw;tered tfad(,lIl)rh 01 Il<lF'f AG. (,errrMfiY_ 

'Oropp and ('illstdr ~fe I rghtefe.u t/'ildCflUd,~ <lnd IJIII;) I~ {I Iraileln<lft <)1 ,\gr[\'O_ 

:iHarvdrie i~ ol registered tr..df'lIJJ(k of \}lIiroyJI (Oll1floll1'j. 

~"lalathiun i~ <l lruuemill k (lJ Amefifolll Cy,uldmid (,lflIPollll' 

t il~ ,\,--::..~,-

AventisCropScience - <:,,-,v"'"%'"'9""'&1 T ;/'-'0 V"-~ W'" L'0,')h L,-

P.O. Box 120H, 2 T.W.Alexander Drive 

Research Triangle Park, Nonh carolina 27709 

PllFr i~ II Ie IfJdelllJlk ul the A\lPn1i~Gf{{!lP; - __ cj,\,~, '" '\ ;Le) 

mt LX i~ <l ft'glSt('ft:'{1 tf<ll.kffi.ak oll!lf' A'{('nth Gmi.!p,~ 

PR/-P'~ IHaml Elhl'phOiI lor (oltnl1 <HId Tohdc(Q (PENOi1\G) S(lllIllittrd 7/17/01., -- {::.J''<-Ct/\'"'' ~ t.cJ 

27 
Aventis Crop5cience 

August 12, 2002 

Document Processing Desk (AM.END) 

Office of Pesticide Programs (7504C) 

U. S. Environmental Prote<:tion Agency 

Room 266A, Crystal Mall 2 

}921 Jefferson Davis Highway 

Arlington, VA 22202-4501 

Attn: Ms. Cynthia Giles-Parker (PM Team 22) 

• Sub: PREP brand Ethephon for Cotton and Tobacco (EPA Reg. No. 264-418) 

Revised First Aid Statement 

Dear Ms. Giles-Parker: 

I am submitting an amended label for PREP brand Ethephon for Cotton and Tobacco (EPA Reg. 

No. 264-418) in order to c.ompJy with the directions set forth in the PR Notice 200l-1 (First 

Aid) 

This submission contains the following documents: 

l. An application for new registration/amendment (FomI8570-1) II copYI 

2. Amended label for PREP brand Ethephon lor Cotton and Tobacco 15 copies) 

e ffyou should have any questions. please contact me at (919) 549·2302. 

Si~elY yours, " 

--+i- ?7'>_~"..C f·y!52.-

Prasad Rao 

Registration Manager 

E-nlail P[jJ:-'iilt riJ.!J"itil\fJltL\ (\1111) 

A\'''lllj~ CnlpS;;;ielll" . 2 T\V '\1C\,lIHJ~t' Dn..-e I{c;,,;n.:h TPnlHfjJ-l'!&R XC 277cr-} 

Tclcph"Ill' \91'» 549 lunD 

•••••• 

• •• • •• • • 

••••• • • • • • •• 

••• •• • • ..... • • 

••• 

• •• • •• 

• 

• • • ••••• • 

• ••• • •• •• • 

• 

• ••• 

• • •••• 
-- --- --- ---- u." _~ ___ 

- -- -- ---- ,--~ -~ ----- --~--- --

. J3 - '" .' ~ 

United St,t .. Registration OPP Idonlfflet NtmOet 

oEPA environmental Protactlon Agency ~ Amendment 

W .. hinaton. DC 20480 Other ,;J. S' ,).5 '11 ~ , for , - II 

1. Comp,nyl1'toduct Number 12. EPA Product Mot\eo4r 3. PrGpOlod CI .. IiJic«ion 

264418 i Gites--Parker DN- o RHtrict.d 

i4P~EPlbrand'tth!~h;~ for Cotton and Tobacco 

PM, 

22 

5. Heme om Addr ... of AppUcltnt (lndulh ZIP Cot/llj 6. Expedited Reveiw. In occOfdllfl« with AFRA Section 3(cJj3) 

Aventis CropScience (bHil. my product is similar Of' identical in composition and labeling 

P.O. Box 12014, 2 T.W. Alexander Olive to: 

Research Triangle Pari<, NC 27709 EPA Reo. No. 

D ChH:k If thn,.. n.w addnu . D, t Name 

I - II 

E Amendm,nt· !.xJJtein below. U Fir>II printed Iobol. in rep.o.,., to 

:= [J 

A-o-nev l'mlr "ted - RnubmI.lion in te.,xJn .. to AIiI.nov l'It'r dated_ "Me Too· Applic:eon. jj Natillaatl,n· Explain bo!ow. 0 Other· Explain IHIcw, 

Explanation: u .. additNlI101 peg_til) It nKosl-4fy. {For •• ction llItId Section IIJ 

ReviSed FIrst Aid section of \tl-IIlabel to comply with PR NotiCe 2001-1, 

, - III 

, ..... , Chikf..RHlIJtont P.ok.g!/IG . Unit hckogina Wilier SofubI. Pacboino 2. Tvp. of Container 

Et - V" - Vu 

N. - No - N. g~~ PI .. tic 

... , 

" d 11 -Va'· No. par ~ 'y ... w" No .... ..... ' 

Unit PlIOkaging wgt. <,ontain.r COfItaintlr """', 

, <. , '.f ..... 

f ...... U 

f. MatIMl in Which label I. Affb:~ 10 Produ.:t ~-

I~~ u "' .... , -IV 

11. ',N, 

1".:::"",_ n •• NO'. {I~ An. eo.:t.) 

Registration Manager 

Certification 8. Oat. Application 

I ccnily th61 the ltotomtntl I h~ mad. on tN. fonn 4ItId eft attIIchmUits thereto et. 1JufI, _~ and compf,te. ....... I odtnovrledp tim any knowfir.glty f.,. or mitIl .. ding .tatemant may b. ~ by fine Of ImprleoM\aM or .··~edl both I,jnder IIppIicabf.l.w. : :: ••• 

II 13. litle : • • I' 12.,= • • Registration Mlllnanger ••• •• ••••• • • • • • •••• 

4. Typ.dN_ 5.~o • • • •••• •• • • • Prasad Rao August 12, 2002 • • • ••••• 

• •••• 

EPA FMm "70-' IRw. "04' • ""HI",,, """ ..... ;1::; I 

l 29 
_ ...... " .. ""'.-.~~-----

J • 

• w. ". 

,,. " , A, O""N,. 

Unilod Stataa: Registration OPP ld/lMlffot NumbM 

&EPA Environmental Protection 'Agency - Amendment 282591 WathiOQlon. DC 20400 - Othor 

I for . J. 

1. Complmy/Pfoduet Numbtt 2. EPA Product' MaMg/lt 13. Ci .. dfiCflIlQn 

14. CompanylPtoduet INam.) \ PMI D~,.. o Rea1rictad. 

5. Nam. and Add,.... of AppllCiant 6. Expedited Review. In accOld~~~~.FJFRA Sectioo3tc){3) 

(bHiI. my product is similar or i ' and labeling Ito, ./ 

EPA Reg. No. 

0, Name j/ 

\ , • II / 

ArnoI'dmMlI' ~n b4low. A \ On .• .L in rdporwe to 

datod 

RHUbmiulen In ,,",pon .. to A;MlcV lener ;;I"IM 

No00c6tilm ~ ExpIwn balow. o ;7.:A~i'''''' \ o fxpWnboiow. 

Explanation: v •• Mkfitional p.lslll ,,"OSIUlry. (For •• ellon Seclion II 

/ ) . • 

1,. " Will .. / \ 

Ch!Jd.RwUenl: Patlkaglr.g ;/ Iw,,,, 2. T",", of ~ntai,,*i Bv,,' 18:' f= v" \ ~~W pjptic N. N. .,-

• .;~ N ••. "" 

If -Ye." '1/ •• .., .. Pop" must ~~il , ' eent_fl.r Pad:.aga WIJI .". 

, \ 

~~ ... , 0 L.oboI o ConteiMf ~/ , •• ""' I \ 

6. MbnMt In Which Labell. Afftxe<f,n: Pt()(!OOt ,. ,\ 

~ U Oil", ."\ 

··IV '\ 1.Co_tP~" ,H. '."'- iN ... " Titl~ "" No. (tl'lClUda At .. Codel 

Certification 8. Oat. Applin.tion 

I aortlfy that tM etot9fllOnili hoWl moo. on this form or.d ell attachments tMrfito ete true, ooeut.tte end complete. RflC.elved 

I aeknowl.do- th.t -nv knowingly f.h,. Of mislood#lg .t.lemont may be, punilhilble by fino 01' impriumment {W' I (Stamped) both under ~!lc:WI.I.w. 

12. SigMWte 3. Title 

4. TvPed Namo 5. Dille 

EPA.om> 657'" tRoy, .... , ... Whlu • El'A "" Copy Appllunl Copy 
• 

PAPERWORK REDUCTION ACT NOTICE ond INSmUCTIONS 

INSTBUCDQNS; Thi. hlfm ill to ho Uled fot fill appjlclltiCru: for mow tl/gillff.tion, ~md UII" '"/Ioh.trauon, amendment, toBUbml.don. to 3PPfjeation!l 

1(1( MtilloaU:-, final prinlod 1ab«lfIQ. twogi,tratJon, ote:. In o«ilu to PIOCOIII '" ."plle,ti"n for II new ttgisuation 'ubmined on thi' form, tM 

f!lftowing metflfial rmHIt Mleotnpany the ~cn: 

f. Cartlflo"tll," with nefPoct to Cit.tion 1)1 OIftD (EPA Form 857()'291. IIf flO! n:emptltd by 40 eM 151.81 tb114lJ: 

2. ~ntW St.temont of Fomwtl IEPA Form 867()."iJ 

3. FonnuIatw'. Exemption Stetflmftnt (V'A Fo"." 8:510-211; 

4. RVfI 1IOpi .. of draft l#beling; 

5. ThfM copk. of any dltlo .ubmluod; 

6. Authorization tatt" who,. ~c.ablo; 

7. Matrlou whel'li eppIIcebfo. 

I'''''''''','''mo''''',,"'',. Labllflno .MoId fir.t b. IIUbfri;tttd in tl'lo form of draft Iabo! .. with aU applications fot new tegi,lr.tkwI. Such dr.ft illboh, mIIV bt 

jin the- fCfm crl typed fetal !art on 8.5 x 11 tflll.h peper lot IWbmiu.ion Ot a mccl::up of tn. p~ fAba!. If prepac-.:i' fM ~, It .twukI bo 

in. way '" 10 feeHitet. stolage in on ItS )( t 1 inch file. Mockup lebels eiorJficantly turuII1ar than 8.5 x 11 inchu,~ be /l'lQUntod r.ln 8.5 

:x l1i,r.c~_ ~~!..fot aubmiulon, 

OIlUl wbmlthtd In $UPport of thi' I/iPpflutlon mutt be tubroitttd in II(lcordM\Cle with PR Nolle. 8&-5. AI 

1~~~I!'IS!r!~~U!~~1J.!~.PlaaJI-III"d the imtNOtion:o ij~t&d bafew bol(>r(1 completing tNc 6pplie4tien. Fiun det.nnine tho "C~ :~,:~'~';"~~"'::II i ~c.~.O(l, ~".t.~ in Bl~ck_~:.~~.W~~h you .fe IIUbmittinu thill !lpptil:tltion, ,fot appllllation~ S-\.I~ttlJd In COO(wH)Il~n wi~ N"w new.Uetion _ 

II, I~~I fa c(jmph!titd by the I!ppikent. FOf applkatione wbtrutted m COMGIlli/Jf\ with amend&d Hllt6Q'III-tr.tioh .ction-c, ra#ubmlt-.lOM. 

tategistr.t$oM, .te" Section, I. II. end IV must b. e-cmplotl!<l by tM llflP!lcant. 

Ch.eIt. th. tlppfOptiate eetlnn for which you ere submitting this form. 

1~if!;:r!Qnlu '··This lIIeetlan mullt DI6 compi'lI!&O, .. IIPPlh:.ulbl., f()f all reQielte«on .etlorur. 

1. Ct!mpfllylProduct Nul'tlbv - tnsert your C!m1pllflY Humbt!T, if Qra rnu: bllum 1I,.';on\tJJ by EPA. Thk numbef may he .... befll ".fiQtl«i to yw I!lIi /I 

bMie r.gi.u&nt •• dilltribuwt, '}f all.., .,tab!illt-.I'!Unt. if 't~t ptoduct i. t3-giJitellld, tnJilllrt tho Pr/'4uct Numb.t. 

2. EPA Pt~ Mana .... • II Known. t\I! in.the: mIDltlffld PM hUrrU.l!1t of tM EPA Ploduct MflMQ$r. 

3. Ptop_d a .. -.mc.t1on· SpeCify tM ptOfX>H;d etfWriflutl.;;n of 'tN. prmWM. 

4. ProduatN.I'I'MI' fntoth~.-t.ptodl.ltt n_ {II thiJil ~,t(cldc'$1t will $(>pller Of! tho label. Tho nllmO mullt b. ~f!c te 1'.hI$ ptadvct rmly. 

Dupfication of 0IImfl i$ no-tj1!uminod liffHH)Q p;odvcu- 01 tttl'l $JmW Ctm'tfi8ny. Do nIlt Indtldfl lIny In4rld 04lM- W ¢Ott'IfimV!intl d~tloM. 

5. NOrM /MO Ad....,. clApplkaiot~ Tho twI'Io of dHl fifm or ptf&G1'! .w 1'Idd~$ ,hown in yetit ~¢4t!M it tM I»f1IOO or firm lG.-)YMm tho 

1~{Jl .. tr.t1on will b<llsw.d. If yeu ..-. $4ung 1ft bohalf of llOOthor !NItty, 'fOOpl\Wt $ubmit .uthoritatitm from thllt pMty to lIUlt flU thorn In ~n1ion 

mau.r •. An appfic.nt not l.mdilllJ in tho Unltod Statn mutt hiNt VI .ruth<.irtzed itQllnt wthungln tim Urntad Slm .. tt act fo1 them In Ill! 

IIIW,Uation mDttolll. Tho fl«im. rrod vomplllt. mGi~ng oddlU5 (if $uth!!f! a~nI tm!_1It aeeompony fhli Dpptie.tion. 

S. ~dll.d '\6ww . FjFRA 'OI!etloo;} fe} 3 IBI plOvkh~$ fot IIxvtlditee reVilllw ot ~fltil}W$ fOl' ftQj5UlltlOn, or ~nu to .Jdftl~"'~~::~:'4i that lit. t®mlI., ()f id.noe.l to otMr PlJlltickll~ ptt<ductl: th6t anI Ol.iffOnUy I.t.r&d with tta- EPA. In oro.t tOf y«lt aPPIIcatklfJ_IO :. 

e~pOOit6d reviow, ytJU mutl1 I)fOvWO u" with tM EPA ReQillfhlWn Huff\bll( 6ild pMUtt n&n'I!!I of tM proouct yeu b.IIl""". 1= similar to at 

YOUt ptoduct. Tholl ptoduet muJ.t b. timilllr or idelltkal in twtn fuqnuhltWl'l .nd lilb6lbd U$OUI. 

1. Subi-et ot, .l.Ibmis,don • eM!)k the nppticahle binck. ami prov>dlij tM AOl'ney t"Uer d.11I H J!lf'PfepriMo. PU.I\Ikf" e britf .xlilfI:Mtmll.9f tn. PUfJ1$'li.{~1 

fot tM \Wbmi,tit>fl. su¢h Ita -the ildd,tlo" of it site, ye$t ct filliP {!lplleifyt; -nmend tta (01)fid!lntia1 St6t~t of formula bY .. ,"; -,eteoistrntion 

ftUbmlWOl\-; -(JeMroilatm r.~ 01 u,. d;,&<::tlGIW.~ Anlleh III iMP.tete P&Oe iI itddlfiomi1spae. i.t tloW4crl. 

~~~~"~nl~:::::~ and COrita/ruft Infotmilltien! - TNt Sectil;1n mus-t be eorrq}/eted fet a!luppfieatioru: Mlbmitted in oomaction wHh new 

amtndmal\t$. 

1, TVPft of PmegIDg ~ Chocl<; tn. apPlepritltj) Meck if VGur ploouet w:llile pnck_Oee in tt. .. mdi.mtOO plldegil'lQ t'm". 

Indfeete tho .-11" of 1M individual fHlckM1 aM numb.r I'M tHai! CiH'ItMnlH. 

2, T~ of n-.t.a ~tlllt.r· todleat. typt <'II centllil!M in whic:h filiXlm:-t will bo rn.,btlld. 

3, L<'IC8uon of N.t ¢ofttOJ1t1' • Inditat. tl'<$loa!l:tion of tho rat 1,l0n«tnU' lnlorrnalion fat '{t:Iur PI(>duc:t. 

4. Sluts) Qf Jk~ Cont~· SJMiC'i(y tn. IUtt eOOl/mt, 01 tdt fateil oonwl>OfS for yoor saoduet. 

5, LOCflIkm of u.. tXr.ctf_· IMiGlite tho loeaMl'lot thl! U$O dllltCti<'lM fot YOiII Ploduct. 

S. MlllfflH' in whict! Jebtil!. affb:ed to ptodue1 . IndieiJt.d the matfwd product lab&! if 1Irn.;::hDd to rotall ecntoiflltt. 

ltV ' Pnln Tro' S.dion roupt be enmpj"ted fot oII.,:;phcllt'oml for RegiJlr.ation ."tionll. I_e., new prodUclO rogiGtr.ti(ln, 

~na.t(lo." tlllegi'-lrotion, .tc. 

1·5. Soll-flxplflMtory. 

G. EPA UN 0nI,/, 
• 

• 

PRASAD RAO 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

08/21/2002 

AVENTIS CROPSCIENCE USA LP 

P.O. BOX 12014 

2 T.W. ALEXANDER DRIVE 

RESEARCH TRIANGLE PARK NC 27709 

OFFiCE OF 

PREVENTION, pESllCIDES A.NO 

TOXIC SUBSTANCES 

PRODUCT NAME, PREP BRAND ETHEPHON FOR COTTON AND TOBACCO 

COMPANY NAME, AVENTIS CROPSCIENCE USA LP 

OPP IDEN1'IFICATION NUMBER, 282591 

EPA REGISTRATION NUt·mER: 264-418 

EPA RECEIPT DATE, 08/15/2002 

SUBJECT: RECEIPT OF ~YJENDMENT 

DEAR REGISTRfu~T, 

The Office of Pesticide Programs has received your application 

for an amendment and it has passed an administrative screen for 

completeness. 

Du~-ing the initial screen we determined that the application 

qualifies for fast track review. The package will now be forwarded 

to the Product rlJanager for review to determine its acceptabil ity. 

If you have any questions, please contact C. Giles-Parker, 

Product Manager 22, at (703)-305-7740 . 

Sincerely, 

<~;t/Aat· 

Front End Processing StafE 

Information Services Branch 

Program Management and Support Division 

lnlcmCI M<lr1iss(VRlj. http:ir,\i·",w.cpa,gcv 

R~d«lm.;;;)'d~bI0' P,I"I"d MIt! Veg~u.bl(l 011 &~ed l"lIs on Recyd.,d Paper IMI"I,.""" 50% P()s!cOn~u'M' co"lc"l) 3 2 
-------------~ 

.. ,-.~;., .... ~ 

1"HO;-':'I" rCND"I'Il()<'I':SSING APPl,ICATION INF'OHMAT10;'\ C!IECf( I,lST 

-- -_. ~---- --.~ ~ -- ----------~--~---------- --. __ .--------

PM ,,;2? ~--~ 

EPACOMPANTNUMBEI1.,,~Y"I- Si//( 

, 

, 

'1MB-TOO" CITED PRODUcr STATUS A<;rrVE, __ CANCELLED' __ 

NOTINREFS, __ _ 

• 

• 

33 
WITH DATA 

!NIT. 

FEU __ 

SIG(DATA) __ 

PM 

• 

• 

APPLICATION FOR AMENDMENT 

DATE 

NO DATA 

!NIT. 

FEU-7'-:' ;(J ~ 

• J 

PM .~.;2, 

DATE 

OPP # ,-?,f2;9 s-9/ 

34 
• 

• 

PESTICIDE REGISTRATION ACTION TRACKING SYSTEM (PRATS) CODING FORM 

BAR CODE~g16~ ID NUMBER: :2.(;'-/-'-/ l~ ACTION CODE, 300 

PM, 22 RSVIEWER'._-EG\."2-UiVl DUE DATE, \I I 13 1(l2 

DATE ON APPLIC.~TION, "l I I b I 02-

EPA RECEIVED DATE, 'K / 15/ 02-

PM RECEIVED DATE, 'i / r;; / 0 :2-

APPLICANT,_AlLe.vJ: I;S Cd-v-r ,sc:-; Vb C-L J PI'el. s= 0 J. 8,,, 0 

CHEM CODE (11, Q q '1'3 0 I CHEM : -"E-c=-l±1 .... ,,'+,~~>.Jh!:..Uo<JhLL..------

CHEM CODE (2) , ____ _ CHEM, ______________ __ 

DATA REVIEWS: 

HED: RCAB __ _ TB, __ _ RCB, __ _ DRES __ _ 

OREB __ _ 

10 __ _ EEB __ _ EFGI'/B, __ _ ERCB, __ _ 

BEAD, ACB. __ _ BAB, __ _ EAB __ __ 

RSB: PCRS __ _ PRS, __ _ PCS __ _ 

PM Team: Carl __ _ Paul Vern, __ _ Bill ---

FINAL ACTION, RESPONSE CODE, RESPONSE DATE: _1_/-

75-DAY RESPONSE: YES NO MOS: (1 ) CITE ALL 

CRP: YES NO 14 ) NOT APPLICABLE 

RESTRICTED USE, YES NO (8 ) SELECTIVE 

EXCLUSIVE OSE: YES NO 

MANUFACTURiNG USE: YES NO 

CONDITIONAL REGISTRATION/UNCONDITIONAL REGISTRATION 

NOTES: 

35 
&EPA 

United StMo' Envirlmmflntol Proteetkm Agonoy 

Office of P"ticide Program. tH7505C) 

40t M Stroet SW ( ("' 

Wa.hinUton, DC 20460 ,-

Notice of Supplemental Distribution of • Registered Pesticide Product 

~::.:~:~a~~,.~e,gistrant has obtained final registration for the basic product. the registrant may then supplementally . hislher product. One form must be submitted for each distributor product and must be signed by the 

Involved. The basic registration number and the distributor company number must be shown. 

;~~~;~~~;'a~ has a potential distributor who does not have a company number assigned, shelhe should have the 

apply, on letterhead stationary, to the Registration Division to have a number assigned prior to submitting 

to the agency. 

Notice of Supplemental Distribution must be submitted by the basic registrant. The complated form must have 

concurrence and signature of both the registrant and the distributor. 

Note: Do not submit distributor product labels 

Product fbQic prodlJCrflllm(lllCc.,)t~ by EPA} N~. 

Royst~r-Clark, Inc. 

999 Waterside Drive 

Suite 800 

Norfolk, VA 23510 

Cottou (Iud POP In! 

R .. d All Condition. &forti Signing 

1. The distributor product must have the same composition as the basic product. 

2. The distributor product must be manufactured and packaged by the same person who manufactures and packages 

the registered basic product. 

The labeling tor the distributor product must bear the same claims as the basic product, provided. however, that 

specific claims may be deleted if by doing so, no other changes to the label are necessary. 

The product must remain in the manufacturer's unbroken container. 

5. The label must bear the EPA registration number of the basic product, followed by a hypen and the distributor's 

company number. 

6. Distributor product labets must bear the name and address of the distributor Qualified by such terms as ·packed 

tor .•.• ·distributed by ... ·; or sold by ... • to show that the name is not that of the manufacturer. 

All conditions of the basic registration apply equally to distributor products. It is the responsibility of the baaic 

registrant to see that all distributor labelino is kePt in compliance with requirements placed on the basic product. 

Distributor ••• • •• 

irorond to m6lktlt 011' product und" th. Distributor Producr Nama $ptlCifi...-Jllbow, IJIlb;.ct re th_ com1itiortS JlptlCif'ftHI 0,; ·th-' NoD . 

Regiatrent 

..... . . 

• •• . 

•• ... ~ .. distriblltor f'lNtMd ItbOV1ll may distribllta.rnJ $11/1 tha Distriblltor Producr ~&d Itbo~. $ub;.cr to til. cOf'ldltloM~M • 

•••• 

• • •••• 
Paperwork Reduction Act Notice 

The annual respondent burden for the Notice of Supplemental Distribution of a Registered 

Pesticide Product is estimated to average 15 minutes per response, including time for 

reviewing the jnstructions, searching existing data sources, gathering and maintaining the 

data needed. and completing and reviewing the Information. Send comments regarding this 

burden, to chief, Information Policy Branch, PM 223, U.S. Environmental Protection Agnecy, 

401 M Street, S.W., Washington, DC 20460; and to Paperwork Reduction Project (OMB No. 

2070·0044), Office of Management and Budget, Washington, DC 20503, Marked "Attention 

Desk Officer for EPA." 

• •• •• 

. • " 

•••••• • 

•• • 

• • ••• •• • ••• ••• • •• , . •• 

•••• • 

• • ••••• • 

. •••• . •••• 

•••• 

• •••• 

37 

• 

• 
PI(lUO Read 

&EPA 

Ullited Stalot EnvironmllOllIl Protmion Agency 

Office of PHlicidlll Prog11lm. tH7S05C) 

40t M Str", SW 

Wuhington. DC 20460 

Notice of Supplemental Distribution of a Registered Pesticide Product 

a registrant has obtained final registration for the basic product, the registrant may then supplememally I ~:~:~:g~:~;hjSlher product. One form must be submitted for each distributor product and must be signed by the I ~ involved. The basic registration number and the distributor company number must be shown. 

a registrant has a potential distributor who does not have a company number assigned. sheJhe should have the 

distributor apply, on letterhead stationary, to the Registration Division to have a number assigned prior to submitting 

this form to the agency. 

Notice of Supplemental Distribution must be submitted by the basic rogistrant. The completed form must have 

concurrence and signatute of both the registrant and the distributor. 

Producl 

Note: 00 not submit distributor product labllls 

Rooi.llred Product Ibnie' prcduct n_ tlCcoprtHi by EPA) 

brand Ethephon for Cotton and Tobacco 

! Oislributor Produci Nllmtl 

I Prep brand Ethephon for Cotton and Tobacco 

8I'ld AddlHS of Oislributor ITypo: incJudo ZIP cod.1 

CRoP P{(.CDll..-c .... \ 10 N !;f!;/tv lc-eS I INC~ 

z52>"- "'-. 7 I "*- 5" 'e"" T 

p~ o. Box 707500 

ILL I", "- 0 K 7'1170 - 7500 

Condition. &fortJ Slgnlng 

The distributor product must have 1he same composition as the basic product. 

The disttibutor product must be manufact1Jred and packaged by the same person who manufactures and packages 

the registered basic product. 

The labeling for the distributor product mUSt bear the same claims as the basic product, provided, however. that 

speCific claims may be deleted if by doing so, no other changes to the label are necessary. 

The product must remain in the manufacturer's unbroken container. 

The label must bear the EPA registration number of th. bnic piCd .. .::;t. f;::.:kj\".'ec by a hypan .. rid the dietributar'S: 

company number. 

6. Distributor product labels must bear the name and addtess of the distributor qualified by such terms as ·packed 

for ...... distributed by ... "; or sold by .•. • to show 1hat the name is not that of the manUfacturer. 

7. All conditions of the basic registration apply equally to distributor products. It is the responsibility of the basic 

registrant to see that all distributor labeling is kept in compliance with requirements placed on the basic product. 

Dlitributor • 

irl(flnd to mllfi:or our product undu Ihll Oistrjbu(cr PrCduCI Name #p.clfifld 4JbOIlli'. $ubftlct to tht1 conditions $p«ifilld ~ 'lJt.it Notico. 

Registrant 

•••••• • ••• : : ;111 • 

• 

•••• • • •• • 

tigrett thtH Iho distributor n.mod .bov. mlly dhitribur.1tfId $IlJl the OistTibutor Producr SfH!Cffntd .twvv, QU&;.1:t to rhft c:pndilfpns $p«:ifi.d on 

this NoriC/l. • .: ••• 

Signllturr 

lnge H. Davis, stration Coordinator 

Form 8570--5 (R ..... 2-921 Pt .... ioo. tldititm. lIle o04OIot •• 

0"" 

•••• • •••• 

3-
• • 

Paperwork Reduction Act Notice 

The annual respondent burden for the Notice of Supplemental Distribution of a Registered 

Pesticide Product is estimated to average 15 minutes per response, including time for 

reviewing the instructions, searching existing data sources, gathering and maintaining the 

data needed, and completing and reviewing the information. Send comments regarding this 

burden, to chief, Information Policy Branch, PM 223, U.S. Environmental Protection Agnecy, 

401 M Street, S.W., Washington, DC 20460; and to Paperwork Reduction Project (OMB No. 

2070-00441, Office of Management and Budget, Washington, DC 20503, Marked' Attention 

Desk Officer for EPA." 

• ••• • 

•••• 

• •••• • ••••• 

• • • • • • • , 

•••• • 

• • 

• • • •• • • • • • •• • ••• • • • • • 

•• • 

•••• 

• • • •••• 

•••• • •••• 

39 

, 

I 
- --~-~~~~---~.---~ ~~- ---~--- ------------

'I 

aEPA 

" 

SIIUOS EovlfMlmMI41 Ploleel~ AIlOllllY 

Ollie, 01 ,."Hoid, PUlllltn)llH750SCI 

40t M 511"' SW 

Wt1Ihinglon, DC 20460 

Notlca of Supplemental DistributIon of a Registorod Posticide Product 

Instructfons 

1':1 . 

AIUH 3 tllgi$tntnl has obtalnod Unal roglstralion for tho b •• k: prodUCI, tho rngiGlr;Jm Tlmy than SflPil!tllTlUntillly 

dblllbule hislher product, Ono 101m must be submIt/ad for each disttibutor product and must be s.lunad by lite 

dlst/ilmto( involved. Tho basic fogistlillion IlUlnbflf alld the dislfibulor cornpilOy 1I111'11ber must 00 shown, 

II it leuistranl hal. potelltial distributor who does not h,lVI a company numbsr assigned. sho{)\Il should have the 

dis/ributor apply, on lottorhOiJd SliltlonPfV, to the Heo)sualion DIvIsIon to /lava a lIumbor iJssiOnod priol 10 $ubmiuinu 

Ihisform to the '(lency. 

TIl;!;. Notice of Supplemental Dlm)butJon must be s.ubmitted by the basic fog/want. Tho complotod form must havo 

tho concurrence *00 .ignltur. of both the registrant and the dlstribulor. 

EPA f!.cDjalllllon NumbCM' 01 P,ccll.llli Db:lrlblWII CMI'I/'IIII'IY NumhllW' 

,I: 264-418~...:'i __ ~_~ __ ~ ________ ~ __ ": 55467 ._ .•... _ .. ___________ . ___ _ 

TENKOZ. lie, 

P.O, oox 1036 

Note: Do not .ubmlt di.trlbutor produtit l.b,l, 

315 toml CAMELLIII BOOLhVARD 

pO~r VALLEY, GEORGIA 31030 

1. The distributor product muat have the ume compo,ltlon as the basIc product. 

2. The distrIbutor product must be manufactured and packaged by tne ume person who manufactures Ind packages 

the reg!.ttred bI.1e product. 

), Joe lilbetinO for the distributor product mUllt boar tho $limo clllimlJ; '$ tho basIc product, provided, however. that 

~ecmc dalm. mlLY be deleted If by doing $0, no othe~ changes to the label Ate necesury. 

~e product mUlt remain in the meoufactuw', unbrokef1 con tamer. ' 

5. The la1>&1 must bear the EPA registration number of the basIc product. follow&d by • hypan and tho dIstributor', 

company number. 

6. Distributor prodUCt I,bell must bear the namo and .ddr." of the dlstrlbutOf Qualified by such terms 85 "packlld 

for",:distributed by .... ; or sold by .... to show that the name I. not that of the manufacturer, 

7, All conditions of tht! basic (egistrati01'llipply oqullfly to disttilJUtOf products. It Is the responsibility of tho basic 

registrant to set that aU distributor labll~ng is Jc&pt in compliance wit.h roqufrflmonts placod on the basic produci. 

Oi$ltlbutot 

Nh inrtmd rll tftMk.r _ ~cr lind", Ih" DllrtiblllDt i+Ddu",r N_ $pf>{!ifiM /tb(>Vff, Aub/l>cr t(l ,h. o:tmrlilmfl.'t "pt>Cifiltd 011 tltIs Noricll.. • •• 

• •• 

•••••• • •• _~~J·.2fH?5 

•• • 

• 

•••• • • 

• • •••••• • 

• • 

. • " .. 
----------------~~~~~------

" 

" 

&EPA Notice of 

United SIBI1)1I Environmentsl Protection Ag6tlcy 

Offle ... of P(l~llcide Programs (H7505C) 

401 M Strool SW 

Washinijlon, DC 20450 

Distribution of a Pesticide Product 

Instructions 

10-31·95 

After a registrant has obtained final registration for the basic product. the registrant may then supplementally 

distribute his/her product, Ooe form must be submitted for each distributor product and must be signed by the 

distributor involved. The basic registration number and the distributor company number must be shown. 

If a registrant has a potential distributor who docs not have a company number assigned, she/he should have the 

distributor apply. on letterhead stationary, to the Registration Division to have a number assigned prior to submitting 

this form to the agency. 

This Notice of Supplemental Distribution must be submitted by the basic registrant. The completed form must have 

the concurrence and signature of both the registrant and the distributor. 

264-418-, 

Note: 00 ncrt submit dlS1ributor product labels 

oj R"OistereO Producf /b8$k: producr nlHrnJ IK:CCPttfd by EPA) Dit:fribulor P,oduef Name 

Alabama Farmers Coopel'ative, Inc. 

p, 0, Box 2227 

Decatur, Al 35609-2227 

Read AU Conditions Before Signing 

Prep brand 

The distributor product must have the same composition as the basic product. 

for Cotton and 

Tobacco 

The distributor product must be manufactured and packaged by the same person who manufactures and packages 

the registered basic product. 

The labeling for the distributor product must bear the same claims as the basic product, provided, however. 1hat 

specific claims may be deleted if by doing so. no other changes-to the label are necessary. 

product must remain in the manufacturer's unbroken container. 

The label must bear the EPA registration number of the basic product. followed by a hypen and the distributor'S 

company number. 

Distributor product labels must bear the name and address of the distributor qualified by such terms as ·pack&d 

for ...... distributed by ... ·; or sold by ..... to show that the name is not that of the manufacturer. 

7. All conditions of the basic registration apply equally to distributor products. It is the responsibility of the basic 

•••• registrant to see that all distributor labeling is kept in compliance with requirements plaCed on the.~uic product. 

Distributor • 

Registrant 

• • 

•• ••• •• • • • • 

• 

•••• 

• •• •• • 

that tlw d;slriburor fJlffllttri above may distribute lUId sell the Distrilmtor Pr-odlJct spec;(ifXi ltb-oYe, 5lJbjcct ro the conditioM tiptXlirmi 011 I thk IV, rico, 

8570·5 f 
• • 

Paperwork Reduction Act Notice 

The annual respondent burden for the Notice of Supplemental Distribution of a Registered 

Pesticide Product is estimated to average 15 minutes per response. including time for 

reviewing the instructions, searching existing data sources, gathering and maintaining the 

data needed, and completing and reviewing the information. Send comments regarding this 

burden, to chief, Information Policy Branch, PM 223, U,S. Environmental Protection Agnecy, 

401 M Street, S.W., Washington, DC 20460; and to Paperwork Reduction Project (OMB No. 

2070·0044), Office of Management and Budget, Washington, DC 20503, Marked" Attention 

Desk Officer for EPA." 

•••• 

• •••• 

• 

• • .... . -

• . .. · ... ., 

• 

.. . · ., •••• 

••• • " . · .. 

• ••••• •• • 

• • 

• ••••• • .. • 

• •••• • • • •••• 

, 

I 

42 
All 

"-_.----------- --_.-_. - - ---- - ------ .. - --- ---

Notice of 

Un'lod 518tcII" Elwironmcnlal Protection Aaencv 

Office 01 Peslicidtl ProglUms IH7505C) 

401 M $"(1011 SW 

Washinglon, DC 20460 

Distribution of a Pesticide Product 

Instructions 

a registrant has obtained final tegistration for the basic product, the registrant may then supplementally 

I ~:!:;:~~:~:his/her product, One fotm must be submitted for each distributor product and must be signed by the J I involved. The basic registration number and the distributor company number must be shown. 

a registrant has a potential distribu10r who does not have a company number assigned, she/he should have the I d;,.,'!butor apply. on letterhead stationary, to the Registration Division to have a number assigned prior to submit1ing 

I form to the agency. 

Notice of Supplemental Distribution must be submitted by the basic registrant, The completed form must have 

concurrence and signature of both the registrant and the distributor, 

Rcg; .. tnllion Number of Product Companv 

i 0,1 3S 

Note: DD not submit distributor product labels 

Registeretd Product !wk; prot/Utlr mmw IICCtlptlXl by EPA} 

brand Ethephon for Cotton and Tobacco 

Name end Addr,," of . ZIP codtlJ 

SOllthern States Coopen'ltivc, Inc. 

P. O. Box 26234 

RiChmond, VA 23260 

Oi$tribulor Product Name 

Southern tes PREP brand Ethephon for 

1. The distributor product must have the same composition as the basic product. 

The distributor product must be manufactured and packaged by the same person who manufactures and packages 

the registered basic product. 

The labeling for the distributor product must bear the same claims as the basic product, provided. however, that 

specific claims may be deleted if by doing so, no other chang"es to the label are necessary. 

The product must remain in the manufactuter's unbroken container. 

The labe! must bear the EPA registration number of the basic product, followed by a hypen and the distributor's 

company number. 

Distributor product labels must bear the name and address of the distributor qualified by such terms as -pou::ked 

for •.. , -distributed by ... -; or sold by ... • to show that the name is not that of the <manufacturer. 

All conditions of the basic regIstration apply equally to distrib,utor products. It is the responsibility of the basic 

registrant to see that all distributor labeling is kept in compliance with requirements placed on the basic product. 

Distributor • .. inwmi to market our product umiM the Distributor p,O<!uct Nttmit ~p#C;mxI abOV6. $Ubjt>ct to tlw condition$ spoclfHXI on th. Noh . ••• _ 

Registrant 

• • 

• •• •• •• 

S-S~q~··· • 

•••• 

· .. •• • 

• • • 

I QlJIrnI thst tho d~""'"to' m_'" ~~o" may distTibuw Md!Wll llu. Oigtributor Product 8p11dfi«J uboW". subject ro tho corntl,J~;~!it1d on 

!Jrm Noliell. • :.: 

•• • 

EPA Form 8570·5 iRav. 2·921 PUW'OU$ edilion,. oro ol»olcto. 
,- -- - -- --" ~--- -- -- - - - - ~ -

• • 

Paperwork Reduction Act Notice 

The annual respondent burden for the Notice of Supplemental Distribution of a Registered 

PesticIde Product is estimated to average 15 minutes per response, including time for 

reviewing the instructions, searching existing data sources, gathering and maintaining the 

data needed, and completing and reviewing the Information. Send comments regarding this 

burden, to chief, Information Policy Branch, PM 223, U.S. Environmental Protection Agnecy, 

401 M Street, S.W., Washington, DC 20460; and to Paperwork Reduction Project (DMB No. 

2070·0044), Office of Management and Budget, Washington, DC 20503, Marked" Attention 

Desk Officer for EPA." 

• • 

• • 

•••••• •• • 

• • 

•••••• • .. • 

••• •• 

• • ••••• 

••• • 

•• • · .. • 

• • •• • • ••• 

• ••• • • • ••• 

• 

... 

• •• •••• 

••• • •• • · .. 

L-. ________________ ~_~_ 

44 
Uniled SIal!)!! EnviroomootQI Proloction Agoncy 

OUial' 01 Pesticids PrO\lIlWT19 (H7505C) 

401 M Strtlet SW 

Wumingloo, DC 20460 

Notice of Supplemental Distribution of a Registered Pesticide Product 

a registrant has obtained final registration for the basic product, the registrant may then supplementally 

~:::;::~~~,lhiSll\er product. One form must be submitted for each distributor product and must be signed by the 

involved, The basic registration number and tho distributor company number must be shown. 

Ifl;~{;;~;~~;'.npt! has a potential distributor who does not have a company number assigned, shethe should have the ~ apply, on lettethead stationary, to the Registration Division to have a number assigned prior to submitting 

to the agency. 

This Notice of Supplemental Distribution must be submitted by the basic registrant. The completed form must have 

the concurrence and signature of both the registrant and the distributor. 

264-418 ! n09078 

Note: Do not submit distributor prodUC1labels 

8thephon for Cotton and Tobacco 

of Oiutribt.ttor tTYPI': includfl ZIP codtlJ 

Tenn~s$ec Fal:TIers Cooperati-..'e 

P. O. Box 3003 

200 Wa.ldron ROCld 

J.aVer':ine, Tennessee 370136-1983 

en-oPR PREP 

"--

brand £th 

The distributor product must have the same composition as the basic product. 

for Cotton 

The distributor product must be manufactured and packaged by the same person who manufactUres and packages 

the registered basic product. 

The labelina for the distributor product must bear the same claims as the basic product, provided, however. that 

specific "claims may be deleted if by doing so, no other changes to -the label are necessary. 

product must remain in the manufacturer's unbroken container. 

The label must bear the EPA registration number of the basic product, followed by a hypen and the distributor's 

company number. 

Distributor product labels must boar the name and address of the distributor Qualified by such terms as ·packed 

for ... ,·distributed by ..... ; or sold by ..... to show that the name is not that of the manufacturer. 

All conditions of the basic registration applv equally to distribotor products. It is the responsibilitY of the basic 

registrant to see that all distributor labeling is kept in compliance with requirements placed on the basic product. 

Distributor 

I

W.m',Md to lIlIN/wr our ,"oduct unde, thq Oi&tribuw(' Product Nimw 3pl'ICirrsd .wOVtl, sllhi-cr to tho condftiOfl$ lIPttcirNid on thi# Natictl. 

• • 

Oato 

• •• •• •• 

• < • •••• • • • 

, 1 is t 

EPA Fein' 8570·5 (Rev. 2·921 Provious ed!i.km, IIr(l Ob90lfito. 

.. . • .. •• . 

. ·, .. . •••• 

.. 
• • 

Paperwork Reduction Act Notice 

The annual respondent burden for the Notice of Supplemental Distribution of a Registered 

Pesticide Product 1s estimated to average 15 minutes per response, including time for 

reviewing the instructions, searching existing data sources, gathering and maintaining the 

data needed, and completing and reviewing the information. Send comments regarding this 

burden, to chief, Information Policy Branch, PM 223. U.S. Environmental Protection Agnecy, 

401 M Street, S.W., Washington, DC 20460; and to Paperwork Reduction Project (DMB No. 

2070-00441, Office of Management and Budget. Washington, DC 20503, Marked" Attention 

Desk Officer for EPA." 

• • 

• • 

•••••• 

•• • • • 

•• •••• • .. • 

••••• 

• • 

••••• 

• • •• • •••• 

• 

• •• 

• •• 

•• • 

• •• •• • • •• 

• 

•• • 

• •• •••• 

••• • 

•• • • •• 

46 
& EPA 

fTWst bo 

Unilod Shllo" Enllironmllfll-al Protoction Agoncy 

Oftico 01 Poslicido Programs IH7505Cl 

401 M SPOilt SW 

Wusnrngton, DC 20460 

Notice of Supplemental Distribution of a Registered Pesticide Product 

Instructions 

<Ii regisuant has obtained final registration for the basic product. the registrant may then supplementallv 

I ~:;:~:g~:~;hislher product. One form must be submitted for each distributor product and must be signed bV the II involvod. The basic registration number and the distributor company number must be shown. 

a registrant has a potential distributor who does not have a company numbor assigned, shelhe should have the I d;SU;~b;'tOr apply. on letterhead stationary. to the Registration Division to have a number assigned prior to submitting 

I form to the agency. 

Notice of Supplemental Distribution must be submitted by the basic registrant. The completed form must have 

concurrence and signature of both the registrant and the distributor. 

Product 

264-418 q ; 51251 

Note: Do not submit distributor product labets 

tbMic product ntlmfl 

Ethephon for Cotton and Tobacco SF S('I'vices IlP.LP !wand Ethepnon for Cotton 

. im:Jud. ZlP CDd.1 

S,p' SCyvicp" r nc ' 

'i3;)Ji Nodh J1},m 51:; , 

Nor I-h ).,ilfle f2lx f , 11 ;<, 

701.//"1 

1. The distributor product must have the same composition as the basic product. 

and Tobacco 

The otStributor product must 00 manufactured and packaged 'by the same person who manufactures and packages 

the registered basic product. 

The labeling for the distributor product must bear the same claims as the basic product, provided, however, that 

sped'fl,c claims may be de:leted if by doing so. no other changes-to the label are necessary. 

product must remain in the manufactUrer's unbroken container. 

The label must bear the EPA registration number of the basic product, followed by a hypen and the dlstributot's 

company number. 

Distributor product labels. must bear the name and address of the distributor qualified by such terms as ·packed 

for •.• ,"distributed by ..... ; or sold by .•. • to show that the name is not that of the manufactUlor. 

All conditions of the basic registration apply equally to distributor products. It is the responsibility of the basic 

registrant to s.ee that all distributor labeling is kept In 'compliance with requirements placed on the basic product. 

Distributor 

I ~' •• ,,~'" ro fMlkllt QUf' pt"Oduct undtK tJt. Dist.ributw Product N_ $pM:i1hHi 400_. $UbjBct to thII c.mditiom: ~1fXI on thi8 Noticf,. 

• • 

• •• •••• Signature and retia of Diouibotor 

(Y-'\ • • •••• • • • 

•• • · " .. IlIgrlHl th,,, t/Hl al$tributor nlll1HKl4bove miry disrrilwtlllllld 111111 thtt DitrtTibutor Product spilCifiM/ ~oVll. subj«t to th. ctmdfr:m; ~ M· 

this Noticf,. • •••• 

i st 

EPA FO'm 8570-5 tRav. 2-921 PrliviouS' edilions "'/11 ",bsoteta. 

· • .. • • 
• • 

Paperwork Reduction Act Notice 

The annual respondent burden for the Notice of Supplemental Distribution of a Registered 

Pesticide Product is estimated to average 15 minutes per response, including time for 

reviewing the jnstructions, searching existing data sources, gathering and maintaining the 

data needed, and completing and reviewing the information. Send comments regarding this 

burden, to chief, Information Policy Branch, PM 223, U.S. Environmental Protection Agnecy, 

401 M Street, S.W., Washington, DC 20460; and to Paperwork Reduction Project (OMB No. 

2070-0044), Office of Management and Budget, Washington, DC 20503, Marked· Attention 

Desk Officer for EPA.· 

•••••• 

•• • • • 

•••••• • .. • 

••• •• 

• • ••••• 

• • •• • •••• 

• 

• · •• .. .. . •• · .. • · .. 

• 

.. . • •• •••• 

••• • 

•• • · .. 

" 

'-----------------,----- - ---" 

48 

, 

, 
. Al! !nllllucliont< Be-folD 

],,) 

Form (Form 

Unitod S\lllil~ Envilonmcnta! Prot$Cllon Agcnoy 

Offke of Poslicido Pfogram$ lH7505C) 

401 M SlIool SW &EPA Wllllhinglon. DC :20460 

Notice of Supplemental Distribution of a Pesticide Product 

Instructions 

After a registrant has obtained final registration for the basic product, the registrant may then supplementally 

distribute his/her ptoduct. One form must be submitted for each distributor ptoduct and must be signed by the 

distributor involved. The basic registration number and the distributor company number must be shown. 

~;::~;~;~;'~~p~:. a potentia! distributor who does not have a company number assigned, she/he should have the 

• on letterhead stationary, to the Registration Division to have a number assigned prior to submitting 

agency. 

I Notice of Supplemental Distribution must bo submitted by the basic registrant. The completed form must have 

concurrence and signature of both the registrant and the distributor. 

of Product Company Number 

I----~ __ ~~_~~_~~ _____ ~L-='--_~,-- 1169 __________ I 

Note: Do not submit distributor product labels 

lK:r:t1PtDf'i by EPA} Dishibulor Product Nomobrand fOI' and Tobacco 

of Distributor (TYJW: includ. ZIP cod.) 

Gold Kist, Inc. 

't"P.I?Epll [b a: /le.gJ....6tVti?.d ,u,adeu!Q.kh 06 

RllOne-Pou..ee.nc Ag Campa-JU( 

244 Perimeter Center Park\-/ay, NE 

P. O. Box 2210 

Atlanta, GA 30301 

Road All 

The distributor product must have the same, composition as the basic product. 

2. The distributor product Inust be manufactured and packaged by the same person who manufactures and packages 

the regist8/ed basic product. 

The labeling for the distributor product must bear the same claims as 1he basic product, provided, however, that 

specific claims may be deleted if by doing so, no other changes to the label are necessary. 

The- product must remain in the manufacturer's unbroken container. 

label must bear the EPA registration number of the basic product, followed by a hypen and the distributor's 

company number. 

Distributor product labels must bear the name and address of the distributor Qua!ified by such terms as "packed 

for ... , ndistributed by ..... ; or sold by ... n to show that the name is not that of the manufactUrer. 

7. All conditions of the basic registrat[on apply equally to distributor products. It is the responsibility of the basic 

registrant to see that all distributor labeling is kept in compliance with requirements placed on the basic 

Distributor 

•••••• • I"' •• "",d to mmlctft our product undsr th8 iJistribut"r Prooucf N_ $pVCifiqd #bov", subjt1ct fo fhe canditiolJ8 ~ttKJ "",this "otic •• 

SignalUlO .,d Title 01 Disllibulol 

G0A$- jif- d;~r:k~ /?2r?~,.- ... c":?,.,,?_,,- ~-~ 

RegIstrant 

•••••• 

•••••• • ~OJ· •••• 

• • tJ??~s:~··. 

••••• • 

•• • •••• 

(aflftHI th.t thlt dl$tributor named obevlt nmy dwtribute and soli thl1 Dis[ributor Product spoci(iBd .wav", wbjuct ro the ccndj60;r,·4ntcirHHf on 

this Notic#. •• • 

EPA Form 8570-5 !Rllv. 2·92) Previou$ editions IIro obsolele. 
• 

Paperwork Reduction Act Notice • 

The annual respondent burden for the Notice of Supplemental Distribution of a Registered 

Pesticide Product is estimated to average 15 minutes per response, including time for 

reviewing the instructions, searching existing data sources, gathering and maintaining the 

data needed, and completing and reviewing the information. Send comments regarding this 

burden, to chief, Information Policy Branch, PM 223, U.S. Environmental Protection Agnecy, 

401 M Street, S.W .. Washington, DC 20460; and to Paperwork Reduction Project (OMB No. 

2070-0044). Office of Management and Budget, Washington, DC 20503, Marked' Attention 

Desk Officer for EPA.' 

• • 

• • 

• • •• • •••• 

• 

• • •••••• 

• 

•••• • •••• 

• 

" . • •• •••• 

••• • •• • • •• 

• ••••• 

•• • • • -..... 

• • • • 

• •••• • • • •••• 

50 
'I 

Unilcd Stales Environm6fllal Protru::lion Ag&flcy 

Office of Pc!ticido PrOijfl.llllS {H7505CI 

401 M Siroot SW &EPA W<lshinglon, DC 20460 

Notice of Distribution of a Pesticide Product 

Instructions 

After a registrant has obtained final registration for 1he basic product. the registrant may than supplamomally 

dis1ribute his!hQr product. One form must be submitted for each distributor produCt and must be signed by the 

distributot involved. The basic tegistration number and the distributor company number must be shown. 

Iflfi~a;;;:~~i:~;"an~, has a potential distributot who does not have a company number assigned. shelhe should have the 

d apply. on letterhead st31ionary, to the Registration Division to have a number assigned ptior to submitting 

form TO the agency. 

I Notice of Supplemental Distribution must be submitted by the basic registrant. The completed form must have 

concurrence and signature of both the registrant and the distributor. 

Number 

Note: Do not submit distrIbutor product labels 

Product {basic product nlJffl#1llCC6Pted by EPA} 01$lribulor Producl Name 

W A¥<-\"c\<.?\'c.\..D 'B'('c;._~ ?\Zc? 

NamG ..,d Addr&" 

WA.vt'~~';;::-\E\....O 

?m, ?,...:9 ..... At 0 

\.)'" ~ 0 ........ <?~~ ;\ \-.{ 

nlNld A11 ComIItiom _ SignIng 

1. The distributor product must have the same composition as the basic product. 

2. The distributor product must be manufactuted and packaged by the same person who manufactures and packages 

tho registered basic product. 

The labeling for the distributor product must bear the same claims as the basic product. provided. however. that 

specific claims may be deleted if by doing so, no other changes to the label are necessary. 

The product must remain in the manufacturer's unbroken container. 

The label must bear the EPA registration number of the basic product. followed by a hypen and the distributor's 

company number. 

6. Distributor product labels must bear the name and address of the distributor qualified by such terms as ~packed 

for .... "distributed by ... ·; or sold by" .. ~ to show that the name is not that of the manufacturer. 

7. All conditions of the basic registration apply equally to distributor products, It is the responsibility of the basic 

registrant to see that all distributor labeling is kept in compliiimce with requirements placed on the basic product. 

Distributor 

I

'W''''',Md to mMkot our product under t'1II Dk;ttibutor Prcduet N_ sp«:ifHW abovu, subject to tlw conditiOlt$ •••••• .J'tICI'fied on this • Nqticfl. • • • • 

Tido of Oimibutof 

-- , 

Registrant 

•••••• 

• 

• •• •• • •••• 

fI{Jf1Hl that tho dmtributor namod """"m" .';SUm.,. and sPII the DitJtnoutor Producr t'ipacifWd libow, st/bjl1-ct to tho c(J(lrfl,&¥~rfi8d on 

•• • 

8570-5 IRev. 2-921 Prllvioos odi!ioo$ 4ro oblloleto. 
--_ ...... _-_._-------------

• • 

Paperwork Reduction Act Notice 

The annual respondent burden for the Notice of Supplemental Distribution of a Registered 

Pesticide Product is estimated to average 15 minutes per response, including time for 

reviewing the instructions, searching existing data sources, gathering and maintaining the 

data needed, and completing and reviewing the information. Send comments regarding this 

burden, to chief, Information Policy Branch, PM 223, U.S. Environmental Protection Agnecy, 

401 M Street, S.W., Washington, DC 20460; and to Paperwork Reduction Project (OMB No. 

2070·0044). Office of Management and Budget, Washington, DC 20503, Marked" Attention 

Desk Officer for EPA." 

• • 

•• • •••• 

• 

• • •••• •• 

• 

•••• 

• •••• 

• ••••• •• • • • 

• ••••• 

• • 

• • 

• •••• 

• • • • •••• 

•• • • •• •••• 

••• • •• • • •• 

52 

• • 

• • 
----------------

I, Cynthia Giles-Parker, Product Manager, Team 22, Fungicide 

Branch, Registration Division, Office of Pesticide programs, Office 

of Prevention, Pesticide and Toxic Substances, United States 

Environmental Protection Agency (EPA), certify that the pesticide 

product (8) listed below is, as of the date of this letter, a 

registered product under the Federal Insecticide, Fungicide, and 

Rodenticide Act (FIFRA) I as amended, and that as such, the 

product(s) may be sold and marketed in the United States of America 

as authorized and limited by FIFRA. A true and correct copy of the 

product label approved by EPA is attached to accompany this letter. 

Registration of this product (s) with EPA also denotes that the 

registrant listed below is responsible for ensuring full compliance 

with all laws of the United States of America, or governing 

jurisdiction, regarding the sale, storage and/or disposal of the 

product(s). Further the recipient of this letter is on notice that 

the status of the referenced registration and/or the accompanying 

label may change subsequent to the date of this letter. EPA 

assumes no responsibility to notify the recipient of this letter of 

any change in the status of the registration(s) and/or the product 

label for the product{s} listed below. 

EPA has issued registration numbers for the product(s) listed below 

to: 

Aventis CropScience USA LP 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, NC 27709 

EPA REGISTRATION NO, ERQDUCT NAME 

264-418 CERONE® 720 

f /j .-..J c , 

, Cynthia GileS-Parker 

Product Manager (PM22) 

Fungicide Branch 

Registration Division 7505C 

53 
r--.------

I 

I IIIn9tructions BIlI",a FOlIO (Form must bo 

United Stst&!! En'l'ironmet\tol Protootion Agency 

Offico of Pcslidd4 P"'gram!l (H7505C) 

40) M Stle"t SW aEPA Washin';ltIln, DC 20460 

Notice of Supplemental Distribution of a Registered Pesticide Product 

Instructions 

After a registrant has obtained final registration for the basic product, tho registrant may then supplemantally 

i i his/her product, One fotm must be submitted for each distributor product and must be signed by the 

distributor involved, The basic registration number and the distributor company number must be shown. 

Ilffi;a't;;i;~~~;";~, has. a potential distributor who does not have a company number assigned. she/he should have the 

d apply, on letterhead stationary, to the Registration Division to have a number assigned prior to submitting 

to the agency. 

Notice of Supplemental Distribution must be sUbmitted by the basic registrant. The completed form must have 

concurrence and signature of both the registrant and the distributor, 

Numbet of Producl Company Numbet 

Note: Do not submit distributor product labels 

I1f n~itJterod Ptiiduct lbasic product nlM'UlllCCltpttHI by EPA} Ohltributol P,oduct N$no 

PREP brand 

Calarco r Inc. 

P.O. Box 727 

Corcoran, CA 93212 

for 

Tho distributor product must have the samO composition as the basic product. 

••• • 

• • •• 

• 

• • 

• • 

• •• •• •• 

• 

• •• •• • ••• 

•• 

The distributor product must be manufactured and packaged by the same person who manufactures and packages 

the registered basic product. 

The labeling for the distributor product must bear the same clairr:ts as the basic product, provided, however, that 

spocific claims may be ,deleted if by doing so, no other changes to the label are necessary, 

The product must remain in the manufacturer'to unbroken container, 

The label must bear the EPA rogistration number of the basic product, followed by a hypen and the distributor's 

company number. 

Distributor product labels must bear the name and address of the distributor qualified by such terms as "packed 

for".,"distributed by,.,M; or sold by"," to show that the name is not that of the manufacturer. 

7. All conditions of the basic registration apply equally to distributor products. It Is the responsibility of the basic 

registrant to see that all distributor labeling is kept in compliance with requirements placed on the basic product. 

Distributor 

I'" ",'" .. tD fTIIHkot I1ur prDducrumilllr the DisuibutIlr Product Non,. specirlDd OODVD. wbject to the cDnditions spncifNxi DII thiJ NIlfic". 

Doh, 

April 19, 1995 

Registrant 

agme that thtl dhJtributof ntuned IJbOvtf may distribut9 and sell ihg Dhtributor Ptf)duct 3IWCHitid IilbIlvtt. "ubj6cr ro the conditions spfldlHKl lin 

thm Notice. 

EPA Flinn 8570-5lRov, 2·921 editkma IIle I1b!lo~t(l. 
-----------------~ ~~-~~ 

Paperwork Reduction Act Notice 

The annual respondent burden for the Notice of Supplemental Distribution of a Registered 

Pesticide Product is estimated to average 15 minutes per response, including time for 

reviewing the jnstructions, searching existing data sources, gathering and maintaining the 

data needed, and completing and reviewing the information. Send comments regarding this 

burden, to chief, information Policy Branch, PM 223, U.S. Environmental Protection Agnecy, 

401 M Street, S.W., Washington, DC 20460; and to Paperwork Reduction Project (OMB No. 

2070-0044), Office of Management and Budget. Washington, DC 20503, Marked "Attention 

Desk Dff;cer for EPA." 

•••• 

• • •••• 

• ••• 

• • •• 

•••••• • 

• • • 

• • • • •••••• 

•••••• • 

• • •• • • 

• • • 

••••• •• •• 

• • ••••• • 

•• • • • • 

• •• 

• •• • 

• • • • •• 

• • 

• • 

55 

s 
• 

• 

UNITED STATES ENVIRONMENT AI. PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

Ms. Gail S. Powell, Ph.D. 

Rhonc·Poulenc Ag Company 

P.O. Box 12014,2 T.W. Alexander Drive 

Research Triangle Park, NC 27709·2014 

Off rce Of 

PReVENTION. PESTICIDES ... TOXIC SUBSTANCES 

July 7, 1999 

EPA FILENO: 264·257,264·267,264·377,264·418.264·498,264·564 

SUBJECT: Certification to Compliance with Child· Resistant Packaging Regulations 

Per PR Notice 96·2 

DEAR REGJSTRA'IT: 

The Office of Pesticide Programs has reviewed your voluntary certifications regarding 

child·resistant packaging and compliance v.ith the standards of 40 CFR 157.32 including the 

revised effectiveness standards: in 16 CFR 1700.15(b), and [he revised testing procedures in 16 

CFR 1700.20 as published in 60 FR 37710 (July 21, 1995), Your certifications did include a 

statement describing the type of package used and its designation using the American Society for 

Testing and Materials (ASTM) Standard D3475·95 "Standard Classification of Child· Resistant 

Packages. " 

Please note your child·resistant packaging certifications will be placed in the registration 

jackets for the above named products. If you have any queslions please contact me at (703) 308· 

7051. 

Sincerely, 

Z4~/2(,-~ 

Eugenia McAndrew 

Technical Review Branch 

Registration Division 

56 
r- . 

$ dJIJ/j -

\ 'II~ RHONE-POULENC ~ 

CRr CERTWICATION NO PACKAGE CHANGE 

• 

• 

RHONe-poULENC AG COMPANY 

Child-Resistant Packagi1lg Stateme1lt 

Date: December 10, 1997 

Name of Product: PREpTM br.md Ethephon for Cotton and Tobacco 

EPA Reg. No.: 264-418 

Registrant's Name and Address: Rh6ne-Poulenc Ag Company 

PO Box 120]4, 2 T. W. Alexander Drive 

Research Triangle Park, NC 27709-2014 

I certify that the packaging used for tillS product meets the standards of 40 CFR 

"157.32, including the revised standards in 16 CFR '1700.15(b), when tested by the 

revised tesbng procedures in 16 CfRI700.20, as published in 60 FR 37710 Ouly 

21, 1995). 

Please note that Child-Resistant Packaging is provided on a voluntary basis only 

for the 1 gallon (3.7854 liter) alld 2.5 gallon (9.4635 liter) containers. 

For 2.5 gallon (9.4635 liter): 

The type of package is a 63 mm, one-piece, reclosable, continuously threaded 

closure with a localized squeeze force while htrning, ASTM Type 1 B childresistant mechanism on an "F" style plastic bottle. 

For 19.1Ion (3.7854 liter): 

The type of package is a 38 mm, one-piece, reclosablc, conti nuously threaded 

closure with a localized squeeze force while tUflling, ASTM Type lB child-. • 

• ••••• resistant mechanism on an "P' style plastic bottle. • 

Sincerely::-. / )," f 

,. 

~ .. r;' /,j / '// II)".'" tl I ,/,.--,t-<,./ ~-, " v~ 

Gail S. Powell, Ph. D. 

Senior Hegistration Ma-naget 

•••••• • •• 

• • ...... • • 

•• 

•••• • • • ••••• 

., . . , . • •• 

· . •••••• 

• 

••• • • • 

•• 

• · .. ., . •••• 

•• • • • . • 

, 

PO eox: !alj·!.:;;.- W Alfr)(A:--;CfR 02.1>11; 

AFS(ARCH 1fl!/ONGl£ PARK, ,. C '71(B·2')\4 

(919)549·200) 

Excellence ifi Pedorrnance 

Pride m Achrevemenl nHFANA'lICN,\(. raE>'. NurJ!lfB 4WJ378---N;SWlf,lll-,CK APC AT? 

INTERNATlO!{.O,l OI$TRlfjUTlon SEII-f,efS >fLEX NUMtlHI 49W377,MlSW(RHACK APC lOS 

57 

-
• 

~~~ ------- - --------

AUG T 1998 

I, Cynthia Giles~Parker, Product Manager, Team 22. Fungicide 

Branch. Registration Division, Office of Pesticide Programs, Office 

of Prevention, Pesticide and Toxic Substances, United States 

Environmental Protection Agency (EPA) I certify that the pesticide 

product (6) listed below is, as of the date of this letter, a 

registered product under the Federal Insecticide, Fungicide, and 

Rodenticide Act (FIFRA), as amended, and that as suchl the 

product(s) may be sold and marketed in the United States of America 

as authorized and limited by FIFRA. A true and correct copy of the 

product label approved by EPA is attached to accompany this letter. 

Registration of this product (s) with EPA also denotes that the 

registrant listed below is responsible for ensuring full compliance 

with all laws of the United States of America, or governing 

jurisdiction, regarding the sale, storage and/or disposal of the 

product(s). Further the recipient of this letter is on notice that 

the status of the referenced registration and/or the accompanying 

label may change subsquent to the date of this letter. EPA 

assumes no responsibility to notify the recipient of this letter of 

any change in the status of the registration{s) and/or the product 

label for the product{s) listed below. 

EPA ha~ issued registration numbers for the product(s) listed below 

to: 

Rhone-Poulenc 

PO Box 12014, 2 T.W. Drive 

Research Triangle Park, NC 27709-2014 

EPA REGISTRATION NO. PRODUCT NAME 

264-418 Prep brand Ethephon for Cotton & Tobacco 

Alternate Brand: Ceronem 

.. ~~--~~ .~. - "- ----

/~/ Cynthia Giles-Parker 

Product Manager (PM22) 

Fungicide Branch 

Registration Division 

58 
... 

/-

~ RHONE-POULENC 

RH6NE~POULENC AG COMPANY 

JlIllL,26,199:4 

Ivls. Cynthia Gile~-Parkt'r 

OffiCI..' of P(~sticjdt' Frog-rillnS (H7505C) 

DOCUlllCllt rroCt~ssing Desk (CER'[) 

L'.s. Env irnnmclltal PruLectinn Agl'ncy 

RUDm 266A, Cry::.[allvlall 2 

1l)2] Jt.'fferson Davis Higlnvily e Arlington, Virgil1.ia 222])2 

Re: CERONI:~'-720, EPA Reg:. No.: 264-418 

PI('dSt' prnvidl' liS with it (l!ftificMp of rl'gisLratioil for the pn.!tiud rdl-'fel1Ced .tbOVt'. Ph'ilSl' 

lLlclude tht' follmdng iuformation un th\' l'('rtificiltl': 

(1) Rl'gistfa lIt: 

(2) ),j,Ulll' uf Ihe Product: 

Rhc'mr-Pmlit.'uc Ag Compilnr 

r.o. Box 12014, 2 T. W. AJexalH.h~r Drive 

R('seHI'(h Tri'lllgle F,lrk, ;\;Ol'Lh Clrnlina 277Lll} 

CERO!'\l:> 720, EP J\ J~l'g. Nu.: 264-11F1 

(1) Th\~ phrase ",,:.Hbl.PJ1.!,.;,'J2frd.Y.QUb£.Jlli[f!e!m>.-b: ., , .. that tlw product Illay be sold dnd 

tnMkl'Ll'u in the Lnih'li Slates of Anlt~ri(i'l for the Wil'S indicdtl'd un Lltt" label." 

A c{lf1Y lIf Uw 11l0s1 nn:nt f::PA-,.,lalllped, <lpprovl'd lahel i5 ('ndo~l'd, PletlM' COllt.1d nw ,IL (lJ191 

5·19-21 12 ~hol1ld ~;Oll have <lily qUt'stinn<;, 

SilwL'rcly, 

.11111ith L ivloorE' 

Rl'gi5tl'<l lion Spl'clalisl, 

Rt'~~ul<1Ll)rr ComrllJ lteL' 

I'n"!ox 17;'~ ;>7 'il f.' L,'~hl.\f;-IIIr:,;f 

Ilfo,F}l,ll(:H ;0,,':1(,1.[ n_n" t) (; NJ J'!.~;,',~ 

:!l ~91 rAj· .!f,o) 

,'/fi'RqA"'O' JA, Jh.L>, 'i'-.i\'SLil 'l'_(l'.':'/0-fNS','.-Oli;.4C"- M';, I, 'I' 

'!rlLll!I.'\Y()!H_~ '.J:~;:R6d'ifl :;Flf-;:CC lflC' ;;...',-,,<.,"1-' ,ri-Jt;'_i?? NhS"i"N> _~;":. J)"; 

•••• • • •••• 

••• • 

•• .. 

•••• • .. • . 

• 

•••••• 

• •• • • 

•••••• • .. • 

• •••• 

• • ••••• 

"' ' 
• 

• 

RHONE-POULENC -

RHONE-POULENC AG COMPANY 

April R. ]998 

Unilcd Stal~S Em irolllH~'JlIal Prole!.:) iun Agency 

OfficL" orpc::.1icidL' Pwgrams 

DOl.'lImeU1 I'roccs::.iug ]) .... s\...( 7505C) 

401 M Street S II' 

Washington 1),( 20460-0001 

RE: Fi"JISt-I.K llarYcSl Aid tiJr COllOIl (H':\ Reg. :\n. 26 .. k'i64) C~cJanjljd(' Tcchnicitl (EPA 

Reg. '-:"0. 2h-l-565 t ~utJ all Rhuue Poulenc Frhl'phon Product.<. (264-257, 264-163. ~64-:?67. 26-1-

292. :::64-':>7b. 26'+-377. 26..J.-.l80. 2(,-+--%18,164-51 bnd 11'14-543 

Dear Ms. Gill.'s-ParkL'r. 

Thh kUC'f is 10 inlimll ~nu Ihm due 10 n.?l:(':!ll tlrg~U!iz<Jli0nal cbJ.J1gt.'s at Rhone Pouknc. I will nil 

longer be handling regislnllion issues on cyclallilid. ..... t:10.']Sf I i~,' brand f-larvC$l Aid for Collon. or 

ethephon prodUC1S. \ifr. Warrcn Davis will assunH: n:g.uLHory rcspollsihiJiti~s for ryd:.milidt' and 

FINISI+J.t. He call b~ r(:uchcu;tt 919~549<:.; 79. \lc :.iick Summa will handk all ~lhl.'pholl 

reglll(1lD~ isslles. \J lek'::> pholle nurnhl.'r is 919- 5..JCJ~2 3 7~. Pk;rsc .addn:ss all tln un.' 

corrcspolKiL-nce 10 ~kk or Warren, YOli sholllJ ~'oniinlll' 10 USC' the 5;1111(.' mailing address 10 

reach :'\kk ()-r Wnrn:n. 

1 havl.' enjoyC"d )\orkmg ~\j1h you ill1(1 panii.:ularly appn.:cialt: alll)fyvur comribu1inH5 to the 

FI:\ISI·1 U r.;~iSJr;lt:un Ihi" pUil year. 1 t;JJl b", r~<1i.:hed al 9!9-5-19-::'687 if~(lu hil\~~ ~Uly qUi.:i->tinn ... 

Gail S, PO\\t:l1. Ph.D. 

Senior Regislration ~Ialtagcr 

PO&JX IX:~ :tT'.-, .\\[:'<.AN";i-.?;:':"-" 

f.1£'5EARCH WIA!'Gt~ ,',ofOr; I. C :::'7;~<'(;1~ 

(91<j) ~49<?;X:() 

Excellenc"! 1!1 r>erfcJ!!nance 

Prrde (f) Achievement IIHEf1IiA,IONAL Tf-fX Nc)',!"fH ~7.B'7ii·A("'·,1,r Rt!:IK :,pc i'l7 

I~JT(ml<\;iDh';L l<;h~'E'J,r(A' ":(G'd><, 1) LFj !.,lNflUl .1j",:,j/J·/d ,S·.V;~'N ,,' Ji! ,- ,os 

60 
----.~ .. ---------

AHONE-POULENC AG COMPANY 

• 

EPA Correspondence No. GSPlethi\J54 

September 17. 1997 

U.S. Environmental Protection Agency 

Office of Pesticide Programs (}l7504C) 

Document Processing Desk 

401 M Street SW 

Washington D.C. 20460-0001 

Atttl: Ms. Cynthia Giles Parker (PM No. 22), 

RE: Ethephon Oat. Compensation (EPA Reg No.: 264-51 I. 264-418 and 264-267) 

Dear Ms. Giles ~ Parker. 

1 am attaching (WO letters relating (0 ethephon data compensation. These were recently 

sem by Rhone Pou lenc to Microflo Company and Griffin Agricultural Products. 1 think if 

is important that the Agency is aware that outstanding compensation COSIS exist. I believe 

that both companies have cited [he studies in question to support their ethephon 

registrations. I will advise you as soon as a dati compensation agreement is reached for 

these studies. 

e If you have any questions concerning this maner. I can ~ reached at 919~549~2687. 

,~.::.~r1' 

{91gl54!1-:1!XI 

Sincerely. 

%J;/~ Gail Powell. Ph.D. 

RegiStr.1ll0n Manager 

IN1£RNATlOf. __ ~,_ . __ ~_._ ....... WEflBACKA?CRT? 

lNT£RNATICh'.£Al O1SHllBunON SfR'IlCES TElEX NUMBER 40000n.ANSwtRBACK ;.PC lOS 

Excellence In Performance 

Pnde In Achievement 

61 
• 

""RH(jNE-POULENC 

RHONE-POULENC AG COMPANY 

Mr. George Thornlon 

Griffin AgrlcuIrurai Products 

P.O.80xI847 

Rocky Ford Road 

Valdost.GA 31603·1847 

September 17, 1997. 

RE: Ethephon Data Compensation (EPA Reg No.: 264·511, 264·418 and 264·267) 

Dear Mr. Thornton, 

I have attached a list of studies and associated costs required by EPA for ethephon 

reregistration. These studies have been completed since our April 12, 1996 agreement. In 

addition to study costs, we have also included costs for a dietary risk assessment, petition 

fees to suppon cononseedlgintrash tolerances, and contract fees incurred in the 

preparation of this petition. Your share of these costs is onc third of the total cost or 

$157,619.00. These costs were nO! included in our prior agreement. Please submit 

payment within 30 days of receipt of this letter. I can be reached at 919~549-2687 if you 

have questions. 

cc: Alan Reade 

Len Castillo 

Peg Cherny 

Jack Boyne 

Cynthia Giles· Parker (EPA) 

)I;~ Gail Powell, Ph.D. 

Senior Registration Manager 

..... r ,,] _)-''''1 ;J.~.,F 

P1 '1 ~i, 

AI L ,,-t 

Excellence In Performance 

Pride in AchJevemenr 

62 
0) 

VJ 

I::thephon Data Submitted to ~t • I; ScplewiJc! 1!J3i 

RafDrencif Study Name Subml,rrn>n 

/ ....... M Stl.ldy Tit/o Year of Stud)" MRID D ... Sludy Cost, SK 

MOA VERIFICATION· HUNT, T.W. 1m. 14C'

VAUDATIONOF GENERAL METHOD FOR THE ANALYSIS OF 1996 44036001 14-JUN·96 $26,647 

POULTA.T1SJEGG ETHEPHON RESIDUES IN A VARIETY OF SUBSTRATES FOR ETHEPHQN IN POULTRY 

171-4101 LIVER. STUDY NO. EC·95·327. JUNE 13. 1996.54 PP. 

so~ MILLER N.E, AND A.C. UU. 1996. 2·HYOROXYE7HYL PHOSPHONIC ACID (ETHEPHON ,- 43991301 ZZ·APR·9fj SS3JlOO 

ADSORPTlON/DESORPTIQN METABOLITE) ADSR:OPTIONIDESORPnON STUDY. RPAC. STUDY NQ. eC-95-314. APRil 

163·1 11,1996,232PP. 

RISK ASSESSMENT KIDWELL, J. 1996. ETHEPHON ACUTE DIETARY EXPOSURE ASSESSMENT. GUIDELINE 1996 44100203 26·AUQ·96 52,099 

NO. NA. TAS, INC. STUDY NO. ETHEPHONOO..(li.AlJOUS721, 1996,37PP. 

ACUTE NEUR070XICITY BEYAQUTY, P. 1996. A TIME OF PEAK EFFECTS STUDY OF A SINGLE ORALLY 1996 440006-01 29-APR·9fi 

81-8 ADMINISTERED DOSE OF ETHEPHON IN RATS. PROJECT 10 97411, BID·RESEARCH 

LABORATORIES LTD., APRil 19, 1996, 132 PP 

ACUTE NEUROTOXICITY BEYROUTY, P. 1996. AN ACUTE STUDY OFTHE POTENTIAL EFFECTS OF A SINGLE ,,.. 44000602 2!:h·\PR·96 $149.280 

61-8 ORALLY ADMINISTERED DOSE Of ETHEPHON, TECHNtCAL GRADE, ON BEHAVIOR AND 

NEUROMORPHOLQGY IN RATS. PROJECT 1097412, BIO-RESEARCH LABORATORIES 

LTD" APRIL 19, 19~, 569 PP. 

SUBCHRONIC BEYR04TIE, A. 1997. A 2·WEEK RANGE·FINDING TOXICITY STUDY of ORALLY 1997 44283001 23·JUN-97 

NEUROTOXICITY ADMINISTERED ETHEPHON TECHNICAL GRADE BASE 250 IN RATS. GUlDELINE NO. NA. 

82-7 BIO RESEARCH LABORATORIES. PROJECT 10 97453, APRIL 28, 1997. 

sueCHRONIC BEYROUTIE, A. 1997. A 13·WEEK STUDY Of ORAllY ADMINISTERED ETHEPHON 1997 442B3002 23·JUN·97 $218,006 

NEUROTOXICITY TECHNICAL GRADE BASE 250 ON BEHAVIOUR, NEUROCHEMISTRY AND 

82·7 NEUROMORPHOLOGY IN RATS. GUIDELINE NO. 82·7. ClINTRIALS BIORESEARCH LTD 

PROJECT 1097414. APRIL 28, 1997. 

PERMANENT TOLERANCE PETITION FEES FOR CHANGES IN ETHEPHON TOlERANCES 1996 l1-SEP·9I) $8,325 

ON MILK. MEAT, AND EGG 

199$, FOOD QUALITY PROTECTION ACTt PETmON FOR ETHEPHQN TOLERANCES; ,goo 18·NQV·96 $5,440 

AMENDMENT TO ETHEPHON COTTONsEEOIGINmASH TOLERANCE -REVISED 

SECTION F AND G. NOV. 19,1996. PREPARED BY CHARLES, CONN, AND VAN 

GEMHART. 

T""" $472,857 

Development SlwIro .. TO"'1 + 3 $157.619 

. - - ~ - - ~ ~ - ~ ~ ~ - - ~ - ~ ~ ~ - ~ ~ - - - ~ - - ~ ~ ~ -- ~ ~ ~ ~ - ~ ~ ~ ~ - - ~ -~ ~ ~ - ~ ~ ~ ~ ~ ~ ~ ~ ~ - - ~ ~ ~ ~ ~ ~ ~ ~ ~ . - " ~ ~ ~ ~ --~ ~ - ~ - - ~ - - ~ ~ 

RHONe-POUt.ENC AG Cp¥PAlty " _ • Page 1 

PO BOX 12014, tT.W. ALE>lANDEROOIVe 

RESEARCH TRIANGLE PA¥.~"",C,-i7700" 
--

'I' '!;,;;;RH;.;,O.,N.,'E;;;"-,;,,PO--.U;;;;;l.E.;;,;'N;,;;C ............. """"""""""""""' ...... """""''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''= 

• 

• 

RHONE-POULENC AG COMPANY 

Mr, CE Formby 

MicroFlo Company 

P,O, Box 5948 

Lakeland, Florida 33807-5948 

September 17, 1997, 

RE: Ethephon Data Compensation (EPA Reg No,: 264-511,264-418 and 264-267) 

Dear Mr, Formby, 

1 have attached a ii$t of studies and a.<;sociated costs that were required by EPA for 

etbephon reregistration after our March, 1995 Ethephon Data Compensation Agreement. 

These studies were required by EPA in an April 28. 1995 data call in, Microflo received 

the same data call in, In addition to study costs, we have also included 1) costs for a 

dietary risk assessment, 2) petition fees to support a petition to increase cottonseed and 

establlsh gin trash tolerances. and 3) contract fees incurred in the preparation of this 

petition, The April 28, 1995 Ethephon Reregistration Eligibility Decision specified that 

these tolerance changes were required. All of these costs have been incurred since our 

prior agreement. Your share of these costs is one third of the total cost for all studies or 

$236,146, 

There is currently an eye irritation study in progress to suppan reregisrration of 2 

lb ethephon end use products. This was also a requirement of EPA 's April, 1995 data call 

in. Anticipated stUdy cost is approximately $2,200. Your share will be half of the final 

cost. We will bill you faT this in 1998 when the study is submitted to EPA. 

Please submit payment within 30 days of receipt of this letter. I can be reached at 

919·549·2687 if you have questions. 

cc: Alan Reade 

Len Castillo 

PegChemy 

Jack Boyne 

Cynthia Giles- Parker (EPA) 

Sincerely, 

~/Zd( Gail Powell. Ph.D. 

Senior Registration Manager 

_I ,,' ,'.,. , 

I - ~ 

PO sox 1201.<1.;:-1'11 ALfXJ.Nf..t;H QPJ'l\;; 

A£Sf.AflCH 1RIAHGLE PAAK N C 27;oo..2'Jl~ 

,91S) S4lf.2OOJ 

Excellence In Performance 

Pride In Achievement INTEANATiONA!. TELEX Nl.JVe£A 4fXiQJlg.ANSV',ERBACK APe AlP 

INTERNAnONAL OlSTA16Ul1Otl Sf:RV1CES 1ELEX NUM8£fl49993n.ANSWERBA{;l< 

64 
(j) 

01 

U~e~~~l~ UJlJ ~Jlw llJ j~ b'A • 

RehlrllllflC. Study »ame 

tGu~l1ne Study Title 

MOAVEA1ACATlON • HUNT, T.W. 1996. 14C VAl1DATION OF GENERALMETHOO FOATHE ANAlYSIS OF 

POVlTAX1SfEGG ETHEPHON RESIDUES IN A VARIETY OF SUBSTRATES FOR ETHEPHON IN POULTRY 

171·4101 UVER STUDY NO, eC·95-327. JUNE 13. 1m. 54 PP. 

RESIDUE-CROP FIELD SEE, R.M. 1995. "MAGNITUDE OF RPA·9094f.iAND ETHEPHON RESIDUES INION seeD 

TRIALS COTTON RESULTING FROM FOl1AA APPUCATION OF 31039B, 1994. STUDY NO, 

171-4IKl US94101R, RPAC AUGU$T9.1995, 7MPP. 

RESIDUE·CROP FIELD NYGREN, A. 1900. ETHREU!lBRAND PLANT AEGUl.ATORlTOMATOJMAGNITUDE OF 

TRIALS RESIDUE, RHONe,PDULENC AG COMPANY, UAA91E16, JANUARY 25, 1995.207 PP. 

171-4(KI 

SO<l MILLER, N.E. AND A.C. l1U, 1996. 2-HyDfl;OXYETHYL PHO$PHON1C ACID {ETHEPHQN 

ADSOAPTIONIDESORPTION METABOlITE)ADSRDPT10N1PESORPTlON STUDY, APAC. STUDY NO EC-95-314. APRIL 

163-1 

RISK ASSESSMENT 

ACUTE NEUROTOXICITY 

Ill·a 

ACUTE NEUROTOXICITY 

81-8 

SuBCHRONIC 

NEUROTOXICITY 

62-1 

SUBCHRONIC 

NEUROTOXICITY 

• N 

1',I996,232.PP, 

KIDWELL, J. 19\Nl. ETHEPHQN ACUTE DIETARY EXPOSURE ASSEsSMENT. GUIDEUNE 

NO. NA. lAS, INC STUDY NO. ETHEPHON 96·01 AUGUST2-1, 1996, 37 PP. 

BEYRDUTY, P 1996, A TIME OF PEAK EFFECTS STUDY OF A SINGLE ORALLY 

ADMINISTERED DOSE OF ETHEPHON IN RATS_ PROJECT 1097411, ,Blc)'RESEARCH 

LABORATO~IES L TO. APRIL 19, 1996, 132 pp, 

BEYROUTY, P. 1996. AN ACUTE STUDY OF THE POTENTIAL EFFECTS OF A SINGLE 

ORAllY ADMINISTERED DOSE OF ETHEPI-tON, TECHNICAL GRADE. ON BEHAVIOR AND 

NEUROMORPHOlOGY IN RATS. PROJECT 10 97412, BIQ·RESEARCH LABORATORIES 

l TO., APRIL 19, 1996, 5£9 PP. 

BEYRQUTIE, A. 19'91. AZ·WEEK RANGE-FINDING TOXICITY STUDY OF ORAlLY 

ADMINISTERED ETHEPHON TECHNICAL GRADE BASE 250 IN RATS. GUIDELINE NO. NA. 

BID RESEARCH LABQRATOA;IES, PROJECT 10 97453, APRIL 28, 19'91. 

BEvROUTIE, A. 1991. A 13·WEEK STUDY OF ORALLY ADMINISTERED ETHEPHON 

TECHNiCAl GRADE BASE 250 ON BEHAVIOUR, NEUROCHEMISTRY AND 

NEUROMOfIPHOlOGY IN RATS. GUIDELINE NO. 82·7. CUNTRIALS BIORESEARCH L TO . 

PROJECT 10 97414, APRIL26, 1997. 

PERMANENT TOLERANCE PETITION FEES FOR CHANGES IN ETHEPHQN TOLERANCES 

ON MILK, MEAT. AND EGG 

YMf of StI.tcty 

'99' 

'995 

1995 

"00 

1996 

'119, 

1996 

1991 

"'" 

1996 

Submlnbn 

MRIO 

- Study eo", $K 

44036001 14-JUN·96 S26.647 

43868343 I·HiQV-95 $203,063 

43532401 I·FEB·95 $32,496 

43991301 22-APR·96 $63,000 

44100203 28-"UG·96 $2,099 

44000eOl 29·APA·96 

44000802 29·APR-96 $149,2&0 

44283001 23·JUN·97 

'4283002 23·JUN·91 $218,066 

11·SEP·$6 $8,325 

. ~ ~ - ~ ~ -- ~ ~ ~ - ~ ~ - ~ ~,~ ~ ~ - ~ - ~ - ~ ~ ~ ~ - ~ ~ - - ~ ~ ~ ~ ~ - - - ~ - ~ ~ ~ - ~ ~ - - - - ~ ~ ~ - - ~ ~ ~ ~ ~ - - ~ - - - ~ ~ - ~ ~ ~ -~ ~ ~ - ~ - RHONE-POUlENC AG COMPANY 

PO BOX 12014, 2TW. ALGXANDER [),.'~IVE 

RESEARCH TRIANGLE PA"o.tf. N C. 2770(0 

page 

,,' 
O'l 

Ethephon Data Submitted to E~ 

R"tOf'fI(1ce Study Name 

fGWdeUne S1udy TIIII 

1996. FOOD OUALITY PROTECTION ACT I PETITION FOR ETHEPHON TOLERANCES; 

AMENDMENT TO ETHEPHON COTTONSEEDfGINTRASH TOt.ERANCE ·REVlSED 

SECTION F AND G , NOV. 19,1996. PREPARED BY CHARLES, CONN, ANOvAN 

GEMHART. 

• 

Vear ot Study 

'996 

17 September 1997 

MRIO 

Submission ""Ie 

18-NOV·96 

Total 

Development Shiite '" Total + 3 

Study (;(at, $K 

$5,440 

$708.438 

$236,146 

O'l . - - - - - - - - - - - - - - - - . - . - - ••......... - ••.•.... - . - . - . - ..•.. - .. - ... - .. - - ...•.. - ... - .. - . - . - - - . - . -

AHONE~POULENC AG COMPANY 

PO BOX 12014, 2 TW. ALl;XhNDEil C;;r/E 

RESEARCH TRIANGLE PI.r.I:, N.:: 27703 

.-- -

P_ 2 

." 
• 

SEP 23 1997 

I, Cynthia Giles-Parker, Product Manager I Team 22. Fungicide 

Branch, Registration Division, Office of Pesticide Programs, Office 

of Prevention, Pesticide and Toxic Substances, United States 

Environmental Protection Agency (EPA), confirm that the pesticide 

product listed below is. as of the date of this letter. registered 

with EPA under the Federal Insecticide, Fungicide, and Rodenticide 

Act (FIFRA), as amended, and that accordingly, the product may be 

sold and marketed in the United States of America as authorized and 

limited by FIFRA. 

Registration of this product with EPA also denotes that the 

registrant listed below is responsible for ensuring full compliance 

with all laws of the United States of America, or governing 

jurisdiction, regarding the purchase, sale, application, use, 

storage or disposal of the product. Further the recipient of this 

letter is on notice that the status of the referenced registration 

may change after the date of this letter. EPA assumes no 

responsibility to n9tify any recipient of this letter of any change 

in the status of the registration listed below, and advises the 

recipient of this letter to request that the registrant provide 

this information if the status of the registration with EPA should 

change. 

EPA has issued registration numbers for the product listed below 

to: 

Rhone-Poulenc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, North Carolina 27709 

EPA Registration Numbers 

264-418 

Name of Products 

CERONE~ 720 

Cynthia Giles-Parker 

Product Manager (Pf.122) 

Fungicide Branch 

Registration Division (750SC) 

67 
,..---... ~ .~ .~ .. - -- -

~ RHONE-POULENC " 

RHONE·POULENC AG COMPANY 

July 22, 1997 

i\4s, Cynthia Giles-Parker 

Office of Pesticide Programs (H7S0SC) 

Document Processing Desk (CERT) 

Us. Environmental Protecnon Agency 

Room 266A, Crystal Mall 2 

1921 Jefferson Davis Higlnvi.\}' e Arlington, Virginia :22202 

Dear Ms. Giles-Parker: 

Re: CERONE" 720 • bl' A Reg. No.: 264418 

" 

Please provide us \vith thret~ (3) certificates oi registration for the product reierenced above 

Please inc10de the following information on Cilch cernficate: 

cr) RegIstrant: Rh(me-Poulcnc Ag Compall)' 

P.O. Box 12Ul4,:2 1'. w. Alexander Drive 

Research Triangk Park, North Carolina 2770tJ 

• (2) Name of the Product: CERONE» 720, EPA Reg. No.: 264-418 

(3) The phrase within the bod\' of the parabTfaph: " ... that the product may be sold and 

nnrkcted i!1 t1');! Unit~d St:ltc:, of ,A,rriCri([l for the \lS,,:~ ;,-,dic'll(:,-~ tin \l,t:' i;;bt>L 

PJ,!~se contact me at (919) 549-2112 shollid YOIl have tiny qUl~stions. 

Slllccreiy, 

! 

-

Judith L. Moore 

Registration Document" Spedalist 

\-":; "'(.if 1~01.1. ~ r .'/1 ",Le;'''1 jDEH "",;[ 

"tS[AFCI" F{i'~I,(;_f "'MY. II:: ~7 ..,-,·1 :.;,'! 

I("'~-' eot.c..:;.tvc, 

rllfRJ'lnTI:)l,N )[- Fi. '1' I'L'FR -"_.) ;:,7,., A' J,,".','(;i'U/.'::" <'<PC 1"17i' 

,'U[WL:" :,CjA; ;:;·~r~;',i'J;-,i3,' "'S'.'f·,~:'; ""-c.,-,- r ;cJ".'""Ul ,F'TXI ;,·,'·;~','.'Ui"i;L" "P:" I::;',; 

••• • 

•• •• 

• 

•• • •• • 

• •• 

• •• •• • •••• 

• 

•• · " • •••• 

••• • •• •• 

• ••••• . " 

• • 

• ••••• 

• • •• 

• •••• 

• • • •••• 

EXCl)lh'JiCe in PetfO/!ll3N:fJ 

68 
,--------------- ~-~~ ~~ 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

Gail Powell 

Rhone-Poulenc Ag Company 

P.O. Box 12014 

Research Triangle Park, NC.27709 

Dear Ms. Powell: 

SEP 23 1997 

OFfICE OF 

?AEVHITION. P'ESTlCIOES 

AND TOXIC SI.)BSTANCES 

Subject: PREp!!" Brand Ethephon for Cotton and Tobacco 

EPA Registration Number 264-418 e Your letter dated August 14, 1997 

• 

The labeling referred to above, submitted in connection with 

registration under the Federal Insecticide, Fungicide, and 

Rodenticide Act, as amended, is acceptable. A stamped copy is 

enclosed for your records. 

Sincerely yours, 

Cynthia Giles Parker 

Product Manger (22) 

Fungicide Branch 

Registration Division (H750SC) 

69 
l 

brand Ethephon FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Elhephon (2·ChlOroethyl) phosphonic acid' ............................. " ......................... 55.4% 

INERT INGREDIENTS: ........................................................................................................................... 44.6% 

·This product contains 6 pounds ethephon per calion. 

EPA Reg. No. 264·418 EPA Est. No. 264-PA·01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

Si usted no ontiendo la oliquela, busque Ii alguion para quo $0 lit oxplique a ustod on defaUo. 

(M you do not undGrstand Iho label, !lnd someono to explain it 10 you in detaiL) 

For MEDICAL And TRANSPORTATION Emergencies .o..ti.L..Y. Call 24 Hours A Day 1-600-334-7577 

~~ _________________ F~o~r~p~R~O~D~U~CJI~U~S~E~1n~f~o~rm~.~t~lo~n~C~.~I~t~1~-8~O~O~·~33~4~·~97~4~5~ ________________ _ 

Tho use 01 fhis producf lor a varioty 01 plant growth rogulalion uses are prOlocted by Uniled Slates and loreign patents including 

U.S. Palont 4,240,819. No license is granlod 10 uso this product in counlri&$. olhor than the Unitod States or lor any use nol 

contemplated by Ihis laboL Uability for palent infringement may result lrom use or sale of Ihis product oUlside Iho Un~od Slales. 

FIRST AID 

IF IN EYES: Hold oyeHds opon and flush with a gonfle slream 01 water lor at loast 15 minules. Get medical altontion, preferably an 

ophlhalmologlst. 

IF ON SKIN: lmmedialely wash skin with plenty of soap and wale" Get medical anenlkin. 

IF SWALLOWED: Do not induce vomiling. Promptly drink a largo ,quantity of milk, egg whites. getatin solution or if thes", aro not 

available, drink large quantilies ot wator. Avoid alcohol. Call a physician or Polson Conlrol Cenler. 

NOTE TO PHYSICIAN 

Treal symptomatically. Consideration should be given 10 the possibility that overexposuflil to malerials other Ihan Ihis produci may 

have occurred. No sp4cific anlidote is available. Probable mucosal damage may conlraindicate the use 01 gastriC lavago. 

eJANGER 

HAZARDS 

PRECAUTIONARY STATEMENTS 

TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. Causos irrovorsiblo ey'" damage and skin burns. Harmlut if swallOwed or absorbed through skin. Do not gol in DYOS, on 

skin or on clothing. 

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and olhor handlers must wear coveralls ovor short-sleeved shirls and shon pants, chemical resislanl gloves (such as 

N~ril&, Butyl, Neoprene and/or Barrior.Laminalo), chemical-resislanl tOOlwoar plu:: socks, pJoteclive oyewear, chemical·resistanl 

headgear for overhead oxposure and chemical·resistant apron whon cteaning equipment or mixing and loading. 

Discard clolhing and other absorbenl materials Ihat havo been drenched or heavily contaminated with this products concentrale. Do 

not rouso them. Follow manufacturor's instructions lor cleaning/maintaining PPE. II no such instructions tor washables, use dotergenl 

and hot water. Keep and wash PPE soparately from olhlH laundry. . 

When handlers use closed syslems, enclosed cabs, or aircraft in a mannor rhat me!)ls Iho requiremenls lisled in \h"·~er Protoction 

Standard (WPS) for agricu~ural peslicides 140 CFR t70.240 (d) (4-6)], tho handlor PPE raquiremenls may be re£M;et; or modilied as 

speciJied In Ihe WPS. • •••••• 

• •• • • 

ACCEPTED 

SEe 2 2 i997 

• • 

•••• •• 

• 

••• · " " . 

• 

• •• •• • 

•••• 

••• • 

• • •• 

70 

•••••• • • 

•• 

• •••• • • 

• •••• 
User Safety Recommendations 

Us~rs should wash hands beloro oating, drinking, chowing gum, using tobacco or using the 10ilol. 

Usars should remove clothing immediatoly if pesticide golS inside. Thon wash body thoroughly and put on clean clothing. 

UsafS should remove PPE immediately aftor handling this product. As soon as possibla, wash thoroughly and chango 'Inl0 cIoan 

clothing. Wash the outside 01 glovos bolaro removing. 

ENVIRONMENTAL HAZARDS 

Do not apply dir&CI:1y to waiar, or to areas where $urlaco waler is prasen! or to intertidal aroas bolow tho moan high wator mark. Do not 

contaminate water whon disposing 01 equipmont washwatofS. 

Do not contaminate wator used for irrigation or domestic purposes. 

SPRAY DRIFT 

Avoid spray drift. Do not apply whon weathor conditions may causo drill, 00 not allow this product 10 drift on to non·target aroas. Drift 

may result in iHegal residues or Injury to adjacent crops and vogetatron, in tha lorm of loaf YGllcwing and deloliation. To avoid spray 

drift, DO NOT apply aerially when wind speed is greater than 10 mph or during periods 01 temperature inversions. USG at larger droplet 

siu wiR a!$a reduce spray drift. 

AVOIOINGSPRAY DRIFT AT nlE APPLICATION SITE IS nlE RESPONSIBILITY OF 111E APPLICATOR. 

Tho Interaction of many equipment·and·weather·relaled lactors del ermine the potontial lor spray drift. The applicalor is responsible for 

a:onsidering all these lactors when making decisions. 

_(he lollowing drift management requirements must be followed to avoid olf·target movement Irom 8arial applications 10 agricultural lick:! 

crops. ThoS(! raquiraments do not apply to loreslry applicalions, public hQalth useS or to applications using dry tormulations. 

1. The distance 01 tho outer most nozzles on tho boom mus1 not eXCQed 3!4the length 01 the wingspan or rotor. 

2, Nozzles must always point backward parallel with tho air stream and never be pointed downwards more than 45 degrees. 

Whore slates have more stringent regulalions. they should be obsorve<!. 

Tho applicator should be familiar w~h and take into uccou nt the inlormation covered in the Aerial Drilt RedUCtion Advisory below: 

AERIAL DRIFT REDUCTION ADVISORY 

(This soctlon Is advisory In naturo and does not suporsodQ tho mandalory label roquiromentsJ. 

INFORMATION ON DROPLET SIZE 

Tho most affective way to roduce drill potential is to apply large droplets. The best drill managoment strategy is to apply the largost 

droplots that provide su!!icient coverage and control. Applying larger droplets reduces drilt potential. but will not prevent drilt if 

applications are made improporly, or under unlavorable environmental condilions {See Wind, Temperalure and Humidity, and 

Tomperalur. Inversions}. 

CONTROLLING DROPLET SlZE 

•

volume • USe high !low rate nozzles to apply tho highest practical spray volume. Nozzles with higher rated llows produce larger 

'roplsts. ~ 

Pressure· Do not excaed the nozzle manulacturer's recommended pr~ssures. For'many nozzlatypes lower pressure produces largor 

droplots. When hlghortlow rotes aro needed, use higher How rate nozzles inslead of increasing pressure, 

Numberol nozzles' Use tho minimum numbor of nozzles thaI provido unilorm coverago. 

Nozile Orientation - Orienting nozzles so that tho spray is released paralled to tho airstroam produces larger droplets than other 

orientations and is Iho recommonded practice. Signilicant dolicclion trom horizontal will roduce droplet size and incraaso drilt 

potential. 

Nozzle Type - Uso a nozzle typo that is designod for tho intendod application, With most nozzlo typos, narrowl'H Spray angles produce 

larger droplets. Consider using low·drift nozzles. Solid stream nozzles orianted straighl back produco the largost droplots and the 

lowest drilt 

BOOM LENGTH 

For somo uso patlorns. reducing the- etfoClive boom length to less than 3/4 ot the wingspan or rotor longth marl~rtl'1fH reduca drilr 

w~hout roducing swath width. • •••• 

APPLICA nON HEIGHT •••••• 

. " 

Applications should not be made al a height graator than to foot above the top of tho targot plants unle$.$ a groat".'ight is fequiratJ 

for airera!! salety. Making applications at the iowest hoightthat is sale reduCQ!> exposure 01 droplets to ovapornt~n and wind . •• : •• : 

•• • •• 

SWATH ADJUSTMENT •••••• • •••• 

When applications arq made with a crosswind, Ihe swath will be displaced downwind. Therelore, on tho up and downwind odg"e~t,Ptt 

tiald, tho applicator should compensate lor Ihis displacement by adjusting the path 01 Ihe aircraft upwind. SwatlJ, ad~1ment distance 

~hould increa~e. with incroasing drift potential {higher wind, smaller drops, ete.l. • .: ••• 

••• .. • 

.. 

71 
~-~-~.~~~--.... ---... - .... -~ .. 

WIND 

Drifl potontial Is IowGst betwGon wfnd speods 012· 10 mph, However, many faetors, including droplol sizo and oquipmonllypa 

dotormino drift potontial at any given spoed. Application should bn avoided below 2 mph duo to variable wind diroction and high 

inversion potential. NOTE: local terrain can inlluoncG wind pattErns. Evory applicalor should be familiar w~h local wind pallorns and 

how thoy affect spray drift. 

TEMPERATURE AND HUMIDITY 

Whon making appfication$ in low rolative humidity, Sq\ up OQuipmont 10 produce largor droplots to compensate for avaporalion. Droplet 

evaporation is most savor. whon conditions are both hot and dry. 

TEMPERATURE INVERSIONS 

Appfications should not OCCtJr during a tomperature inversion bocause drift potontial is high, Temperature Invorsions rostricl vertical air 

mixing, which causes sma" suspended droplets to remain in a concentratoo cloud. This cloud can move in unpredidable directions due 

10 the light variable winds common during inversions. Tomptfraturo inversions are characteri20d by increasing tomperatures with 

allitudo aod are common on nights with llmited cloud cover and light to no wind. They begin to lorm as the sun sets and olton continuo 

into the morning. Their presenco can be indicated by ground fog; however. if fog Is not prOM nt, inversions can also be identilied by tho 

movement of smoko from a ground source or an aircraft smoko generator. Smoke that layers and moves laterally in a concontratod 

cloud (under low wind conditions) indicates an invarsion, while smoke that moves upward and rapidly dissipates indicates good vertical 

air mixing, 

SENSITIVE AREAS 

Tho pesticide should only be npplied when the potential for drift to adiacent sGnsitivo areas (e.g. rasidontial areas, bodies 01 water. 

known habitat for threatened or endangornd species. non·targetcrops) is minimal (e.g. when wind is blowing away from tho sensitive e ueas). 

USE PRECAUTIONS 

Do not apply PREpm brand Ethophon lor Collon and Tobacco through any typo 01 irrigalion system. 

Avoid spray drift to nearby crops as this product will causo modaicalions in plant growth. Plant injury or reduced yields will result. 

Mix only tha amount 01 spray you 9XpGCI to use each day. Do not allow mixed ~luHon to stand ovarnighl. 

DIRECTIONS FOR USE 

It Is a vlolatlon of Foderal law to use this product In a manner Inconsistent with Its labeling. 

Do not apply this product In a way Ihat will contact workers or other persons, either dlutcuy or Ihrough drill. 

Only prolected handl<Hs may be In the araa during application. For any requlremlmts speclflc to your State 

or Trlbe, consult the agency responslbte tor pesticide regulatlons. 

Read entire lab.1 betore using this product. 

Use this in accordance with its labeling and with the Worker Proteclion Standard, 40 CFR part t70. This standard contains 

for protection 01 agricultural wolkers on farms. lorosts, nurseries, and greenhouses, and handlers 01 agricu~ural 

contains requirements for training, decontamination, notification, and emergency, assistance. "also contains 

and exceptions penaining to the statements on this label about personal prote<:tive equipment (PPE).·~~:;(~,~~:~:~ I 

and rastrlcled·enhy intervals. The requirements in this box only apply to US9S 01 this product that are covered h 

Standard, 

Do not enter or allow worker entry into treated areas during the roslliC!od-ontry inlorval (REII of 48 hours. Tho REI is 72 hours in areas 

where average rainfall is less than 25 inchos per year. 

PPE required lor early entry to troated areas that is permill.od under the Worker Protection Standard and that involves contact wilh 

anything that has been treatod such as plants, soil or waler is coveralls over Iong·sleeved shirt and long pants, chomical resistant 

gloves such as ·any waterprool gloves, chemicat resistanttootwear plus socks, and protective eyewear. For overhead exposure. 

chomical·resistant headgear is also required. 

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72 
STORAGE 

Do not contaminate water. food, or feod by storago or disposal. 

tf containor is brokon or contonts have spi!lod, tollow aU precautlons indicated above and clean up Immediatoly. Boloro cleaning up, 

pul on full length trousers, tong sleeved shirt, protoctive gloves, and goggles or lace shield. Soak up spill with absorbent media such 

as sand, earth or other suitable material and disposo ot wasta at an approved wasto disposal facility. 

PESTtCtDE DtSPOSAL 

Postlcide wastes are acutely hazardous. Improper disposat ot oxcess pesticide, spray mixture, or rinsato is a violaljon 01 Fedorallaw. 

If these wastes cannot be disposed 01 by use according to label instructions, contact your Stato Pesticide or Environmental Control 

Agency or the Hazardous Waste roprosontativo attha nearest EPA Regional Oflice for guidance. 

CONTAINER DISPOSAL 

Triplo rinse (or equivalent) Ihe empty containers. Then olfor for recycling or reconditioning, or punctum and dispose ot in a sanitary 

landfill, or by incineration or if alJcwoo' by stato and local authoritios, by burning. If container is burned, stay oUI of smoke. 

RETURNABLE - REFILLABLE CONTAINERS 

tho container to the point ot purchase or designated locations. This container must only be retilled with PREPl),j brand 

and Tobacco. DO NOT REUSE THE CONTAINER FOR ANY OTHER PURPOSE. Prior to roliOing, ,,' "P''''' I 

such as cracks, punctums, abrasions and damaged or worn out threads on closure devices. 00 not 

Check for teaks atter refiWng and bMoro transportal ion. If the container is not being 

GENERAL INFORMATION 

COTTON 

A foliar spray of PREPn( brand Ethephon tor Cotton and Tobacco will accelerate opening ot mature unapaned cot1on bolls and enhanco 

defoliation which can result in earlier harvest with an increased recoverablo yield, PREp!J.I treatment on cotton allows increasod 

otficiency from a onco<lver harvest. 

TOBACCO (FLUE-CURED): A foliar spray ot PREprn brand Ethephon promotos early, uniform "yellowing~ of mature tobacco. 

PREpThi roducos curingtimo, allowing more etficiont use ot curing barn space. and increased control over harvest schedules. 

SPRAY PREPARATION 

Add 112 to 314 of tho required amount ot water 10 the spray tank. Start agitation. Add tho requiroo amount ot PREptJ.1 brand Ethephon. 

and tho romainlng amount of water. Prepare only as much spray solution as can be used on tho day 01 mixing. 00 not allow spray 

solution to stand overnight. Do not spill tho concentrated product on spray equipmont, or any airplane par1s. 

ANY SPILLS SHOULD BE RINSED IMMEDIATELY WITH PLENTY OF WATER. 

Use of a nurse tank Is highly rocommended tor avoiding possible spills of concGOlraled tormulation on spray equipmenl or any airplane 

parts. 

_ANK MIXTURES WtTH DEFOLIANTS AND INSECTICtDES 

~REPl'>I brand Ethephon is compatible with DEFt, FOlEXIJo, Oropp2, Dropp® Uifraw2, Ginslar~2, Harvade3. Molhyl Parathion, GUlhion l, 

and Malathion". PREpm may be applied in sequence or as a tank mIxture (DO NOT TANK MIX WITH DESICCANTS IF COTTON IS TO 

BE SPINDLE HARVESTED). Follow aU applicable use pre<:3utions and rate per acre recommendations on labels of products applied as 

tank mixturo$ or in sequence with PREP N brand Ethephon. In some cases slight reduction in boll opening responso has been 

observed whon tank mixtls with defoliants were used. 

Good agitation in the spray tank is essential and a lank mixture should not be allowed to stand without agitation lor more than 5 to to 

minutes. Read and observe all appropriate labol use directions and prl;;lcautions for the defoliants and insOCljcides used. 

NOTE: UNDER CERTAIN CONDITIONS. TANK MIXTURES OF PREprn BRAND ETHEPHON WtTH DESICCANTS CONTAINING 

SODIUM CHLORATE COULD RESULT IN THE FORMATION OF HYPOCHLOROUS ACIDS WHICH ON HEATING Will EMIT TOXtC 

CHLORIDE FUMES. 

DO NOT MIX PREPn( BRAND ETHEPHON WITH AMMONIUM THIOSULFATE. SUCH TANK MIXTURES MAY RESULT IN FORMATION 

OF TOXIC FUMES. 

EQUIPMENT CLEANING 

• •• • •• ••• 

Bocausa ottha acidic natur& 01 this product, prolonged oxposure to spray deposit will damage acrylic plastics. certain pallll.,.. ••• • •• metals. : ••• :. • • 

Rinse thoroughly with a detergent and wat!)r all exposed acrylic plastk:·typ~ materials (e.g., aircraft windshields), llnd paintod ~~ 

within an hour after exposuro to spray doposits. • •• • • • •• 

At .. the end 01 each day, rinse thoroughly with a detergent and water aU tho metal parts of the aircraft and th·; a;socjate~.pr~ . . .... Gqulpmont exposed to the spray depoSIts. • •• 

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73 
COTTON 

USE EXPECTED PREprn ONE MINIMUM APPLICATION 

CONDITIONS RATE GALLON SPRAY TIMING 

::EEfT'; ~g~~~A~~ I LBS A.1. Acr •• I Air· .. • 

PREpnt Hot and dry 80°F or 1 113 1.0 6 Apply whon the numbor ~I 

Boll Opener·· highsf mature unopened bOIlSt~i: 

Dry and 75 to GO"F 2 1.5 4 10 2 sufficient to produce ,:10;' desired crop. See below 

Cool but abovo 65°F 22I:J 2.0 3 lesl 01 boll maturity, 

or 

Treatment unilormIY.,~~ens 

Rook coHon 

bolls 710 14 days earlier. 

PREp'N + High soil molSluro 113 0.25 2' to 5 Apply 4 to 7 days~~~'I~~~t~ FOLEX· or PREPnl boll 

Defoliant Tank High fortilify IDvel application. To b9 used as 

Mix··· a sequ9ntiallr9almen!.~it~: or nm 0~~C8orpREP~boli I Rook coHon 

·PREPl'1I+ Oropp High soil moisturo 113 0.25 24 10 3 Apply 4 to 7 days_ £,~jO! t~ 

Dotollant Tank High fanility leval PAEPl"d boll 

Mix·· • Rank cotton application. To be us.ad _~s 

a sequontialtreatment with, 

not in place 01 PREpm boll 

Pro·Condltioner Hot. dry. abovo 80¢F 213 0.5 12 Apply -4 10 7_ d,ays prior to 

tor Defoliation Cool. above 65~F 1 113 1.0 6 10 2 defoliant. ._!~~ 

or crop I i 

dOlo rio ration of bollom crop 

Rank colton and allows lor oartier 

• For bost performance. by ground or air applicalion, choose oqUipment and spray volumes that will insurD uniform coverage 01 foliago 

and bolls . 

•• Pretreatment With Defoliants Prior fa PREpTlI brand Ethephon Boll Opening Treafment: II the collon 

is overly rank or laying down in lhe middies and good spray covorage 01 tho bolls with PREPw IS diflicult, a pretreatment wilh 

• 

dololian!s will be us.fulto improve boll coverago with PREprn. Use dosago rates 01 PREPl)l recommendod for boll opening, Road 

and observe all appropriate label use direcfions and procautions for Iho deloliant used . 

.... Can use up to full label rafe lor each product. -. 

ouo In Calilornia and Arizona use a volume of no lass than 5 gallons per acre lor aDdal applications. 

Bon Maturity 

A boll is maturo when i1 is too h3Jd to bo dented whon squoozod between thumb and lingers. too hard to be sliced with a sharp kniht, and 

when tho seed coat bocomos light brown in color. 

Use Limitations 

Do not exceed a maximum ot 2.0 lb. ethophon activo ingredient por aero por year through combinod or ropoa:ted usos ot any 

ethephon products. 

Boll Opening: Do not tank mix PREprn brand Ethephon with a desiccant if the conon is to be spindle harvesfed. 

Pre-Condition for Defoliation: Do not tank mix PREpN brand Ethephon with dosiccants unloss plant d&siccation.i$ r,quired. Do not 

use a dololiant before there is sufficient mature unopened bolls 10 produce the desired yield (see General IrffOU1lfifon section on 

how to test for boll maturity. • •••••• DO NOT APPLY PREpn< BRAND ETHEPHON IF RAIN IS EXPECTED WITHIN 6 HOURS. Rainfall within 6 Mlllrs of.applica¢m Iflal 

reduco product performance. :..... • •• 'O •• 

Do not plant another crop within 30 days alter treatment. Sma" grains planted earlier than t month or intorcr~~d:'lith the &:.0011 

crop to which PREpm will be applied may only be used as cover crops and may not be harvested for food or+Hdo. PREa~tIll .. y 

cause yellowing and growth inhibition of treated small grains, • ..: ••• 

WHEN TO HARVEST COTTON : •••• 

'O'O •• 

Do not harvest collon sooner than 7 days after a treatment with PREpm brand Ethephon, ••• • 

Ob$orvt;) the troated crop and harvest whon optimum boll opening has been roached. Too early haNost might roduce'u¢luli advantage 

01 tha troalment and too late a harvest may result in roduced quality and loss 01 lint which will drop from the plant. 

74 ---~ -----
Crop 

Over-Tho-Top 

Application 

PREprn 

Plnts/Acro 

1113 

I 113 - 2 213 

USE LIMITATiONS 

50 

40 

TOBAcco 

ue-Cured 0 

Specific Directions 

Use drop nozzJ€!$. Choose TG or 00 spray lips designed to apply 50 - 60 

al 35·40 psi and at tractor spoed of 2-3 mph. Use 

2~'~2>~'P;' ~~iw; ono on each side of the row dropped low enough to direct 

tho tho I to be ripened and harvested. Thorough spray 

a diroctod spray, be sure to halVest all loavas 

romaining on tha stalk are maturo. ensure 

remaining loavos are malure, tesl spray $Ovora] tobacco plants as 

doscribGd under tho section ·Proper limo of Trentman!. M Use the lower rale 

in a normally mature crop when experience Jnd'icaies Ihat m'fnlmum riponi"9 

Inducement is requirod. Use the higher rate when tho crop is heavy and has 

a tendency to be mor~ rank or when temperatures oro Iowor than normal. 

Always tGst spray to determine if the tobacco is mature enough to r€!Spend 

to treatmont with PREplj,f 

Apply over-tho-top PREPw spray as a line mist using throe nozzlos (ono 

nozzle tips tho comer of tho plant, and one on each side) so aU loaves 

are covered , similar to the .. of systemic sucker 

J 

Do not apply PREpTH brand Ethophon to immature leaves as this can result in unsatisfactory coloring, woightloss and redUC6d leaf 

qualify. 

Do not allow tho crop to over ripon in tho liold OIlier using PREP~M brand Ethopoon. since this may causo some reduction in yield and 

quality. 

Do not treat before anticipated major storm which could prevent harvost and resutt in crop loss. 

DO NOT APPLY PREpThI BRAND ETHEPHON IF RAIN IS EXPECTED WITHIN 6 HOURS, Rainfall within 6 hours ot application may 

reduce product performance, 

00 not use PREP'l>( brand Efhophon with additives other than recommended on this label. 

00 not planf another crop within 30 days alter treatment 

Do not exceed a maximum of 2 Ibs othophon activo ingredient per acre per year through repeated uses of any ethophon produdS. 

APPLICATION TIMfNG 

Succoss1ul rGsults with PREpn! brand Ethaphon call for troatman! when leaves rue mature, not ovorly rank green when sprayed, To 

.-easily determine the proper treatment timIng and the numbor ot leaves per stalk ready for harvost, test spray several planfs in mora 

~an onO; location in each liold and observe Ihe reSponse. Mature leavils will begin to yellow in 24 to 72 hours. Test loaves thai fa~ to 

yellow in 72 hours ruo not mature and aro not ready for PREprn troatment. Wait a few days to permit further nafural maturing, thon 

make anofhet test spray or Mmaturity" check. 

To avoid quality loss and or po!/.siblo leaf drop, harvest any yollowGd leaves prior !o application. Use lower rates under most conditions. 

limit use of higher rates to cool (below G5F at the tlmo 01 twatmontj stow ripening conditions. 

When you have conlirmod thtl desirad number of leaves pi1r plant that wiD color, you can delermine the number 01 acres to treat in order 

to fill the barn. 

Propare your tost spray by mixing one teaspoon of PREpn< brand Ethephon in t quart of water. Spray each test plant wilh aboUl f oz. 

of this mixture. covering all leaves with a fine mist. PREprn will not color immature sprayed leaves. 

WHEN TO HARVEST 

All mature, sprayed leaves wm begin to color within 24 to 72 hours atter PREprn brand Ethephon application, The yellowing process is 

wealher dependent; cool weather will delay, while hot, sunny wealher can speed up the process. Harvell troated tobacco when leaves 

have reached the desired color 'Intensity. • •• 

Harvost can commance 48 hours after PREpm brand Etht'lphon application. To datermine harvest timing and avd\Q~lIty loss or leat 

drop, closely monitor treated crop and weather conditions. • •••••• 

CURING PREpN BRAND ETHEPHON TREATED TOBACCO •• :. : 

Curing procedures are as much an art as a scienco and each cure must be judged on the basis of tobacco cond~M,·ltltarval Qi~t 

treatment and harvGst, weather and type of curing facfHty before prescription temperature and ventiJation.lc/aedulos c"'l. 

established. To obtain maximum quality, care must be taken to observe and conlrol tho curing process closely,~ly duri~t a 

late ·coloringM and early ·dryingM stages of tho leaL ••• •• • • •••• 

PREPTh{ brand Efhephon tr&atod tobacco will have started tho coloring process whon harvested, reducing thq, tirTVI.roquirod in 1M 

coloring phaso of curing. Treated tobacco should be dried laster. II tobacco loaves are green or contain somo gtmtmon harvosted. 

it may be necessary to color thom for a 1ew hours. If the leavGs are complQtety yollow, fomperarure and ventilatiQl\'llu$~bG adjustod in 

a manner to dl)' the tobacco as fast as possible without scalding. Once the leaf is dried (314 dry), you should follow ntlrlflal procgduros 

for curmg. Sinco PREpl'ld treated leaves cure fastor. Ireated and untroated leaves should not be cured togother in tho ;;me barn. 

75 -.~-~~-~~~~~ 
LIMITED WARRANTY AND DISCLAIMER 

Tho manufacturer warrants fa) thaI this product conforms to the chemical doscription on tho label; (b) thaI this product is reasonably fit 

lor tho purposes sot forth In the directions lor Use when it is used in accordanC4 with such directions; and (c) that tho dirOC1lons. 

werning and other statements on this label am based upon responsible experts' ovaluation 01 roasonablo losts 01 elfectivonoss. of 

toxicity to laboratory animals and to plants, and 01 rlllsiduos on food crops and upon reports oflleld experience. Tests have not boon 

made on all varieties or in all states or under all conditions. lHE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES. EXPRESS OR IMPLIED, AND IT 

EXPRESSLY EXCLUDes AND DISCLAIMS All IMPLIED WARRANTIES OF MERCHANT·ABllITY OR FITNESS FOR A PARTICULAR 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR. ANY AND ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OFl}US PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT. NEGLIGENCE, STRICT LIABILITY IN TORT OR OTHERWISE SHALL BE LIMITED, ATTHE MANUFACTURER'S OProN. 

TO REPLACEMENT OF, OR lliE REPAYMENT OF THE PURCHASE PRICE FOR, lHE QUANTIlY OF PRODUCT WITH RESPECT TO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL INDIRECT OR 

CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHEN USE OR HANDUNG IS NOT IN 

ACCORDANCE WITH LABEL DlRECTlONS . 

... NOTICE TO BUYER 

~urchaso 01 this product doos not contar any rights undQr patonls governing this produc1 or tho use thoroot in countries outsido 01 tho 

United StatQs . 

• 

lDEF and Gu!hion oro rGgistQred tradomarks 01 Bayer AG, Germany. 

2Dropp and Gil'lStar are rogistored trademarks and Ultra is a Iradomark 01 AgrEvo. 

3Harvado is a registered tradomark 01 Uniroyal Company. 

"Malathion is a trademark 01 American Cyanamid Company. 

Rh6no·PoulofIC Ag Company 

P.O. Box t2014, 2T.W. Aklxandor Drivo 

Rosoarch Trianglo Park. Nooh Carolina 27709 

PREP is tho trademark oj Rhono·Poulenc. 

FOLEX is a registerod trademark 01 Rh6ne·Poulenc. 

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PREpno brand Ethephon tor Cotton and Tobacco (PENDING) Subm!lIed tlt6196, Resubmitted t131J97, Resubmitted 8/.l!97. 

76 ....... ~ ... ~.--------------

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RHONE-POULENC 11«", 3D 1 C;StS'l';Y) 

=~.- . '3~""-_"'. E::' ""~~.~' """"-~~""'~;~'--~~-~3"~ 

• 

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RHONE·POULENC AG COMPANY 

EPA Correspondence No. GSP/eth/o53 

August 14. 1997 

U.S. EnvironmelltaJ Protection Agency 

Office of Pesticide Programs 

Document Processing Desk (H7504C) 

Room 266A, Crystal Mall 2 

1921 Jefferson Davis Highway 

Arlington, VA 22202 

A(tn: Ms. Cynthia Giles Parker (PM No. 22), 

1 

RE: EPA Reg NO.264-418 REP1M brand Elhcphon for Cotton and Tohacco: Label 

revisions in respomc to your comspondcm:e of Angost I. 1997. 

Dear Ms. Giles - Parker, 

I am submitting five copies of a draft label with the correction$ which YOII requested in 

your Angllst I, 1997 correspondence. r im\'c highlighted lilL' changes Oil one of these 

labels to [,lCilitate your review. Please note, Rhone Poulcnc would very llluth aJlpreciate a 

quick review of this labeJ Oll your pan. Productioo for PREpTf'.1 begins in November for 

(he 1998 season. We wnuld like to be able to have both EPA and C;liiromia approval 

belore then so fhar we are able to Ilrodllce a)J product for the 1998 se;l.~on with the Sllme 

label. All of the COlTelll changes which have been made on this label are the same ;1$ 

challges already approved by rhe Agency in Jilly whcn the PREP@/ethephon RED label 

changes were approved. 

'fhe following ch:mgcs have been luade: 

Hazards to I hnualls Sectioll: 

Replaced text widl recommellded wording. 

Statement of Practical Trc<ltmcnt Section: 

Clwnged title to '"FIRST AID" 

Deleted "If Inhaled" Statement 

If Oll Skill: addcd: "Get medical :trtcntion," 

If Swallo\','ed: Added "or Poison Control Ccnter", 

Note t\) Physician Section: 

Moved this section (rom precautiollary SW'£Clllell{S to FIRST /\11) sCCI"ion 

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.~~~. 

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Rj 80x !2()1~ J TW A', i:.KAnOEfl 0n.v'~ 

i\E::;Lfl.I1C1111w.r,~t;:: PAlii( tI C n !ff.j_j{:, 14 

III Hl;1;A:;"h,'Y')') 

Excellence in PerformanCe 

'1IfHll>IAnOIJAl lHrx Wil/dFIl ·r):!}}7n,N .. !;:;';[FUJLI-( M'(~ q II' Pnde In Achlevemen! 

IUffRNt.TiCliAL [)ISffl.8lJnUN SUNI(;f-;; 1 n LX hl;15;LH 1)')<_,7;-, "',( 8H"r,L~_:~" M'(; ,,;5 

77 
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• 

Added: "Treat symptomatically. Consideration should be given to rhe possibility 

that Over exposure to materials other than this product may have: occurred. No 

specific antidote is available. Probable mucosal damage may contraindicate the use 

of gastric IlIvagc," This sL.1tement complies with your input and was recommended 

by our corporate physici;m as appropriate for all ethcphon labels. 

Deleted: Entire prior statement. 

PPE Section: Modified glove statement to meet current requirements. 

Directions for Use section: 

Moved first paragraph from Agricultural Use Requirements box to text above box. 

Use Limitations section: Modifed 2.0 Ib alIA statement as suggested . 

If you have Itny questions concerning this matter, J can be reached at 919-549-2687. 

Gail Powell. Ph.D. 

Registration M,magcr 

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78 

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• 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D,C. 20460 

Gail Powell Rhone~Poulenc Ag Company 

P.O. Box 12014 

Research Triangle Park, NC.27709 

Dear Ms. Powell: 

OffiCE OF 

PREVENTION, PESTICIOES 

ANO TOXIC SUBSTANCES 

Subject: PREP'm Brand Ethephon for Cocton and Tobacco 

EPA Registration Number 264-418 

Your amendment application submission dated 

January 29, 1997 

The labeling referred to above, submitted in connection with 

registration under the Federal Insecticide, Fungicide, and 

Rodenticide Act., as amended, is unacceptable. Please make the 

following labeling changes; 

1. Update the Hazards to HUmans section so it reads as 

follows: 

Corrosive. Causes irreversible eye damage and skin 

burns. Harmful if swallowed or absorbed through the 

skin. Do not get in eyes or on skin or on clothing. 

2. Delete the NOTE TO PHYSICIAN statement and add the 

~ following statement: 

Probable mucosal damage may contraindicate the use of 

gastric lavage. 

3. In the Statement of Practical Treatment Section, you may 

delete the IF INHALED; section since this product is in Toxicity 

Category IV for inhalation toxicity. 

4. In the same section as mentioned above, in the IF ON 

SKIN: statement, you must add the following statement: 

Get medical attention. 

5. Move "Do not apply this product in a way .... agency 

responsible for pesticide regulations" out of the Agricultural 

Use+Requirements~section to immediately below the heading "It is 

a violation of Federal .... with its labeling." 

79 
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6. Modify the Use Limitation 50 it is clear that the maximum 

that can be applied to cotton is 2.0 lb. of ethephon as an active 

ingredient per acre from all sources of ethephon not just this 

product. 

Please note that we are aware that the above changes were 

made on your label at the time of reregistration (label stamped 

7/17/97) . 

Sincerely yours, 

hi 

Cynthia Gl{es-parker 

Product Manger (22) 

Fungicide Herbicide Branch 

Registration Division (H7S0SC) 

80 
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PH ~.~ ..., "') 

EPA COMPANY NUl10ER .2-':_(;, 'I ~ g/ 

EPA REGlS'l'lU\'l'IOH IlUl1Blm 

STATUS (For Amendment:s) 

"ME-TOOH eX'i'ED PRODUCT 5'1'ATUS 

PHA'I' RECORD CnEr~'rED 

Active t/ Cancelled __ _ 

Hot in REFS 

Active Canc~lled 

Hot in HEFS 

81 
// 

APPLICATION FOR. AMmIDMENT 

WITH DATA NO PAT1\. 

INIT DATE INIT DATE 

FEU FBU .:h d.~;2 -5--5'? 

SIG (DATA) PH I,;:!.. ,:2-

PM ------

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82 
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

GAIL POWELL 

RHONE-POULENC AG COMPANY 

P.O. BOX 12014 

02/05/97 

RESEARCH TRIANGLE PARK NC 27709 

PRODUCT NAME: PREP BRAND ETHEPHON FOR COTTON AND TOBACCO 

COMPANY NAME: RHONE-pOULENC AG COMPANY 

OPP IDENTIFICATION NUMBER: 242759 

EPA REGISTRATION NUMBER: 264-418 

~ EPA RECEIPT DATE: 02/04/97 

• 

SUBJECT: RECEIPT OF AMENDMENT 

DEAR REGISTRANT: 

The Office of Pesticide Programs has received your application 

for an amendment and it has passed an administrative screen for 

completeness. 

During the initial screen we determined that the application 

qualifies for fast track review. The package will now be forwarded 

to the Product Manager for review to determine its acceptability. 

If you have any questions I please contact C. Giles-parker, 

Product Manager 22/ at (703}-305-5540 . 

Sincerely 1 

Front End Processing staff 

Information services Branch 

Program Management and support Division 

RecyclediRecyclablo 

J>Mlfd wIIh SoyiCal\olD lllk on ~ fl><Il 

C<I~lll"',"I"'I~~\lH' 
'" .•. , 

&EPA 

• 

United lhfitlU 

Environmental Protection Agency 

W4,hlngtOJl, pc 20400 

I-- Registration 

~ Amendment 

'- Other 

242759 

1. CompanylPrcduet Numb.r 

4.' 

Is, Narno and Ad4r&1W of II IlncluOI1 ZiP Cedel 

Rhone-Poulenc Ag company 

P. O. Box 12014 

Re'se'f"ep.~Trian91e Pack, NC 27709 I -, Ch-;;;; if (his jp tI n"w nddtoil'S 

for ," 

2. EPA Prod\lct M!.nilGf/t 

c" 

PM' 22 

" 3. Proposed Cfl1uifKllltion 

o NOM 0 Ro~trietlXl 

6. Expedited Reviaw. In accordance with FIFRA Section 3(cj!31 

~bHil, my ptoduct is similar or identical In composition and labeling 

to, 

EPA Reg. No. ___ . ___________ .. 

Product Name 

, " II 

Explanation: u.o additIonal peg,*1 if fi<jclltisary. (For fl"""on J and Soction IL) 

-Changes in "Directions for: Use and E.~~~ction-,~~for Tank Mixtures" 

--

"ru----------~~~--~ 

2. TV.,. of Ccmtrurwr 

Glen, :::~' PSP'H 

Other ISpeeifyl. ___ ,,' ___ _ 

If Myu~ No. pM 

UNI PackugiflQ Wilt, eontaIner 

3. ,., N,," : 4 ..... ,,' "". 

lliJ ""'" 0 Co",~~' 1, 2.5, 5.0, 30, 110 aa\/bulJ->:-! :;::'t:E: prOOtlc:t 

~.-.. -M--'"-"'--'-'"-Vl--N-'.-h-L-.-b~--i.--A-ffi-•• -.. --'.--P-'.,--'_" ___ .. ~ ... ~ i 

Wrapper g 1 !)OO to,~ 

ins Label 

11. Cont&(;t Poll'lt 

Gail. Powe~l 

, elV 

Il&b. 

I ""'. . Reglstcatlon 

Certification 

Manager 

I cartilv Ihllt Ihl! lltntl!montll I h9VS mooe on tN. form a!'ld $3 IIttflchffitml$ th~falo fire tru., &tcursto and complelll, ~ ::::" .. I tld:nowlodlJj!l thai any knowIngly fDiu <n ml;JeliKJing Iltlliomenr mi!ly bit puNch:&tll. by frttb I:;If imprilOI'\mOni or 

hoth UM" applle,blo law, 

I ,,} (Stamped) 

r-- 12.s_""'~'",,~/a~/14~,J]~rJ~· ~IjY~~t ·.flO! __ _+3~'''''~'==~~----~I~ Registcation Manager ~ 

4. TyplifJ NIlll'It' $,ollte 

Gait Powell 

EPA Fo<m 867 .. ' (RoY ..... , -

. 
--_._-

• 

PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

PAPERWORK REOUCTION ACT NQTtCE; PuI>Hc reporting trurd," lor this tlullcction af information is Mtlmated to $ljIlTGIi1' 0,85 houtjHlf 

((!$peMl'I, >'¢!uillng 11m3 fOf re\4uwlng inilitroctiom;, searohing &)(l$\/ng data lI00fl!Il$, gntharlng.oo mnintaln/nu liw d.\lw Mooed, and S(l~tlng ond 

rtvlaWihO tho Co!/(I!Hlon of information, S;ma Gomfth:lh\lt ti!g&ttHng tho b<lrden utlmate or any cInar aIIpect of thi, colHu:tlon of In/ormation, including 

suOaa3\ions '(If riitdudnq thh' uurd<i"!1, to Chief. I,.,"-'rmati",., Pelley IiHIru;h, {213Gl. U,S, EnltlrOl'olThllntlll ProU.ction AO<lnev, 401 M Stroot, SW. 

W4$rnngtor:, D<': 20400, 

INSTBUCTlONS: Thl$ (orm if! to bIJ us!'!? for cll applieiltior;$ {(If MW tOwstrlitlon, and 1.1$0 flltoQilmalion, alT1endlT\l:lllt. tl)wbinlUion, to II'pplilllltiolHl 

for n(HifictItJof'lll, tinm printGd Itlbeli"'\J, Iflrl.)(Jiutnltjon, IiIlt. ttl ord~f 10 proceu an 3PpiicaUon fat II twlW rdglS"trotion fwhmluod on troll form, the 

lollowin:1 mal1Hlm must I'lCeCmpIlnV t!tll Gppliem).:m: 

1. Certlfletttioll witl! R.upetrl 10 Cl1i11titm "I 011\1> (EPA rerm $570-29). lit not tl"l<empt'l'd by 40 em 152.31 (bj (<Ill; 

:L Confodeotilll Slatlllllflnt 01 Fctnwia itPA Form 8570>4); 

3. FOlmul/ltOf'$ f>i!ffl\ptioh Statum .. n! ICftA Form SS70·2.71: 

4. Flv!} eople% of dreft Ilibellng; 

5. Thli!l0 eopl<w of #fiV dalll l!ubmhted; 

o. AuthMilllJion ltottCf whlUfI IltpKtr!0l;;; 

7. Mlltrico$ willlr!> epplleOOIIl. 

Submk~l6h of lllu¢!{ng " lhbt~Jjno $hCtuld fj,~t b$ ~,-,bn-Jufd in lllll ferm of u(!lft Icl!eli> wilh Ii!! eppticetiuJ)Q fer MW rffDl~trl}tlWI. Sl.ICh atllft 100/)1$ IlWV hI! 

in the form oll','11ud label [ext en 8,5 l( 11 Inch !"'):lSt fOf !1ubmiimico tlr lil trHH;kup Dr th0 Pl6potud Iwtl, Ifprepllted formO(:jQJp, it $tmuW Ia 

t;Ul'lStructt4 ill 11 ¥lOY as W fzci/it6!e ll!GraiJ4 m en $,5 x 11 ;rwh fih. M'Kkup l!lbth: !fi(:Jr~hel!iltiv :IImaJ1er than $,5 xli ltwrnHj should be moumttd {ttl 8,5 

y 11 ;nell PllPM 16r tubmiw&ion, 

Submi"don of 011111' OM,. sut)(l'~tt"il ill "WIi!:>Gn; of lhis oI'PDlid!l1!Ofl mutt b~ subrnittd If) e,;:cord .. m;e with PH Notice 86-5, (It 

ill..C1F!C INSTRUCTIONS; Pi~il~11 n&! (he i<;ttrud.!6I'lli bted b~bw bilk"" compbt,l1[l tfuS epplic&tion, Artl deteHnhw the tWit (If f$Qi$triltlMI 

tlGUon, til<km If! 81c'0k A, fOt wNch '10'-' Nil u,blnmmo this NPI'HC1!hol1, Vcr q,pth;ali!)l"w tublf'lftN in cor.f(tcti"n Witt; Naw Rtgi1>lf~ti6f1 actiom;, S@c\klm 

I, 1H, lind IV must be (omph!!!!d Ly Ih", llpplJuiiM. For GpfJlitdWns 'll1,lbmithtt'l ill COHI1*,,;;un with umerdw INllglstrnti{H'llllctioM, re$\lbrnllldoM, 

rQJ!lic4'iofl$, 1l!U!;f,ttuatIOti:>, !Ht., Siiot;lif;IW I, If, Gnd IV !Twn b& complalad by the "ppliGJlIlt. 

ill",;k A· Ch;;r,J,: tho ltflP,oprlil((I IK"!iQ'" for which you "m sutmHlillll tll)s fDlm, 

SECTION I . Tffi~ Motion mutt tit complt.g,;j. WI ll[miia,bl"" for ejj mQl$lttljion 1l.(;1lr.",,,. 

I. CompenyiProduu Numbu· IrH'llIrl yevr C"mt:Hlny NumDtt, ,f orm fHW be"l1 4#"'Yfl¢cl by EPA. Thb: number rrury fu:\la been 1n,w"rwd to you 1l$ '* 

t;"'tiC r00!H!4nt, 4 d'$lribuIM, 6t Wi' ik' !JffAbbthrr","t, II your PWd';.H:1 ill r"'ub-tcrud, in/ant the PrOO\H:t Numher. 

::L EPA Ptodut:t I'th .... agll( 0 If known, W! j'(j iM n"nw ll1U PM number 01 !M- EPA Prooutt MEnllgM" 

J. Pr/}jlC4"!l(j' CllirowficMIm\. Spec'ly lhlt P(;:'PQ%W <;,j;%mfil:llliGn of til". plodue!. 

4. P(od\Je1 N&IT'dI· Enter the compl611$ fHlYlu-c.! Mr0& of thil! !HMtid" bllil wi!1 4'(;8$1 tift In{< l;JotL nw rtam6 rffiJ~t be- speeiflc 10 OAt prMU(lt only. 

DuphtlHwn of fllliT!<l'S i1; nN pj:jffl~it~d Mwn\:l pI¢d\Jch, cf tho ::-IIm!! ~mtlp@ny, 0" not ;ndude- any br;;nd mUTH.! ot ¢OffI9&1fflitM dIl4ijm1th:ms, 

5, N'Itm. $rid Add,_ 01 A!Ij1:1kMnt' Too mum!' IA lilt> firm IH per1!OIl and &ddrjJJ!@ dlOwn In yWt appltcatitm is Jlw pefilon &r firm til' whom Ihg 

f¢u'QHhlitm wi!! he inWlltt If yIN lifO lwtir,a in beh.clf of (lIH;;tt\l]I( PMty, y;-lti imillt lluOmit euth(lfiz<:!lIon from tlvlt l'iiVty tQ act 1& IhMft III r&{lill!lf61lM 

multN$, An uPPU;;/>l!l net (fH!id!n-g In tII\lI Vnii<'i-d StdQIl mUd f1i:lvt! an auth"r!n,t.! egen! 11lMJing jI; the UnitW' Stat .. ; to Mt fIX th;nn in /iU 

r~oi1Hrill;':1fl matt<lf'#, Tho IHlmo nm! compliH6 nMi!lflQ aJdretll of w,wh Cil J>lj{!nt (tIti$t ifOotmlpenr this &pptlaMlon. 

tL E:'1"adllad.fl~Vi%W: FlfR-A section 3-lc) ~ (ej pfDv;-de* fOf <::'1;)00;1«1 rtNiew ~f uppliC-lltitlM for reghmllliM, cr em'H;dow~u; to existing l,ttu\'tl1!Wfli,) 

tll"'t Me mrrulM Ot khm1lcml til Qtlwr pti~t!tod$ pwduc:tll Jh!lt are CUrrlh'llly r&u,wler<'>d with the EPA. In erda, for your ~ei!thm to lM elig!bla for, '_ 

fwpadjtlld fllvllilW, 'loti rtIti$t proVio", tiS with [ha EPA !\nO!Sfll<ilofl NUIY,vllr lInd proouH n&lie !lllho pfiXfuct you b&lil!v(!l!; lllmifu to Ot jdilnliecl to 

your product. Tnllt Plodllel mut! b .. iIIirrHU or ;der;!ic:ci ill both f<lfm\llMkm Am! loo"led u\l4!l. 

SECTION II • TN, !lH}lltio-ll tn\J!lt {HI emnplet.x! Im.-.1l <1fpiio<1t)""g ;H.lomiUed to 6ffHmd tM I1lIJi><tratiOrl ohly of <I: t:urrenuy f8W&tlltW j'ilc4U¢t 

lAm'lmimelHl, fe< II r<Hllubrnh:-§ion j~ f:lltpl)f1,,:e It) -Uf> Agency lltl\or, flJr lWtllltiM'erm W the A\i$fWV. fot 1M ",ubmill'$lon of flM primed fnholinU, fer 

r"HlwMrillkll1 find for !lny other MII"n th<lt p"'t"''''~ !tl ;'j lw~<;lfii:' g?A·rQ\1h!MOO pf(,.j',ct. This g~ctlen "t i!i2! 12 h2 Ulied fur JiI ""w bppIIt .. t],:m lor 

r"oi,llal)on_ 

I. SUD~ct of iliubm!lflIloo • eM!)k the !!ppr.ogblll block {1m:! pro'lidl) ttl<> AQOnuy !uner datlt 'f &pproplj!llft, P.ovil1<) u brief oxpianothm o-f tm. p\.lrpo&cls) 

fur the ;!;ubmission. ,-"ch IH' "the MdJti&n ;)! Ii ",!te, peit or !:fop lfpeclfyr; ~ijmllnd too C{)nfid~nti~ $11'iIemcnt of FOm\ulll bV,.,~; ~t<'l(~!l-tr;jrJan 

~ubrni!ltlotl~; ~gentfcl f.mltl mvi~lorr {)f <is!! dUeniQrm.H Attm:h a sttpnrtlte PftlJl' [I eddit!ol'l1H fpMe il ",ednd. 

SECTION III {Paokllgino amJ Contairvlf Infolmmlt;nJ . ihill Section mtmt bo eorrl'plllt¢d f<)f att tlppllc81kmn submiuos(f in connection With fI!IW 

rtuistrlltiofi or ucplfcahlu iml6m!mijl'lt1l. 

I < Type 01 Packaging· Chock the IIPpmprillt<! block if yllur pr;;;d!H:t w1l! Ile pili:kaj;ld in the IndicotmJ ptwkawnu typos. 

Indicats tntl gilt! of tlw: Individual pdckal$" and number per r.;;lml (;on\clmlf, 

2, Typll! of Rfltllil Cor;'tllintf· IndioJlle typo of eCfltrnnllf in which prvdu¢\ will bo O1mk4tod. 

3. Locatinn 01 Not CcnllilnW " hldieat~ tha !<Icalh'.m of lila r:l)t tl(lnlimta information {(lr ¥"ur prodUtlL 

4. Si:l:fI{~1 (II ltatllU Cootlillner· Splloity thll net contuolS 01 lill retail contlliMf!ll Il1t ylltlf product. 

S. L()oedon- of !he DIrection. ·lndicUle tho locanOIl of thu use d,r$Cliof1$ 101 'lour product. 

6. Mannef In wh,ch lab.1 k aflb;od to product Indlcllted the lnijtnw proo\u:t lilbel h~ 111l3Chod to rlltml (;onlalnlllr" 

SECTION IV (Contact POInt)· TN. Section mUllt i.l0l c¢ll1pj!!t<ld fa afl appli(13tior:lIlor Atwetratinn &eli(m,-, ).0., new prfX!u.:tt r~lllr$llon, 

rll$obmill$jon. ~1"l>1)·too,· re-rog!st/o\ion, lite. 

1-5. SlIlf·(lltplanatQry. 

G. EPA V,,, Ody. 
0 ....... j/ 

-----~------

j,:! 

-~--- Un!Ud StD'U,$ 

Environmental Protection Agency 

WaehillQto!'l, OC 20460 

for 

I-:-:- Reglstratlon 

p{. Amendment 

L- Other 

" Section I 

( 

''''''". 

11.< Number 

? 

i4 ., H~""'l 

'P 

13. Pfcpcaod Oe .. irtOotlon 

ONen. D RII.trietlld 

j',,, -, Q, d. .' f. .', : 5, Nnnw end Add, ... of App5Clfnt (lncluda ZIP CQdo} 6. Expedited Review. In accordance with FIFRA Section 3(cH3) ::w, mv product)s similar gt identical in composition and labeling 

EPA Rog. No.~~~~~~~~~~~~~_ 

Product Name 

, " II 

I

i Amendment - Explain beloW. 0 Rnlll prinred labalal" r.'p<m1l"6 to D Aglmcy IIIItG! dated -------"'0,----' I 

Rewbmluion in rcspcmo to AIlO'rnlY louo, dllllld ~------ n ~Me Tco~ Application_ / ;:~, 

o N~lieation· Explain b&lcw. U Othor· E:.!piain balow. -:i 

ExplanatIon: Use itddilloMi pIIO"hl) if n/tcafll1:Cry, (For $aellon I and SoctiO'n ILl 

') 

I~' .~------------------_4 

~'U~iC~~_:~:_' ______ ·_·~·· ______ ~~~'~7:~;~.~.p_'~_'~'7~_ng ____ --1"~.~~' If "Y •• ~ No. plH' ~ylll"~ No. por ~ Pap.r 

Unit P&Ck'glWJ wgt. conlalner wgt conlaiM'r f/' OtMr ISpl>CifVI ______ _ 

3. ,,!N,,' 14. $I",., ... , 

g] I.B1af 0 Containar 

r'-' M_'_'"_'_'_'",-W_"_'_h_lob_ "_'_'_A_"_'_"'_'_'_P_''''_"_'_'_ .... ~_ oh 

CertificatIon 

[g] Olher 

·IV 

10" 

Pl;-H5tir- Vkv,,:,,·,'i.- _?'ii"f' ,.-, 

CDM.nne(DOn(,(id( '.eipe' 

I.~ ... I certlfy Ih6t too otfltomt-nls I have mode on this iorm -And ail stt&ehmllnts thbreto are tria, .ec:urate Mod eompIetll. I.i· 

I ~-::.2!'~"~'~""~W~''''7''~'''~'~·~'''!!::k~''_W_''''_Y_'_''_'_'_'_'_~_·._'- __ '_'_",--:-:::-"~' ~ __ Y_b_'_"'_"' _____ bY_r"' __ M_""' __ '_~_""" __ "'_'_' __ ~i. b..... 4Stampedl t hoth undO'r lew. 

~2~'S~i'M~~~·D~<~~~_D~f~'~~i~(~I~·/ ________ -4~3'~To_·~_'~D~f:"~":7~'I:,"~G':"':'0:: ________ ~i~ 4. Typcd Nona 5. Oot. 

EPA Fomo 8670-', ......... " • Copy 
PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

PAPERWORK REQUCTION ACT NOTICE: F'lJhlili r6portlna hurdcl1lor this tallctnJeri' of information is Ktlm6t&d 10 Werage 0.85 hour por 

renponec. '''<Iudtog t!ow fO( ''''''I1Winll inlUrul.llioiW, 1lI0atchlng: omllhno dllta Boureutl, oathering lind maintaining t!w date needed, 4I'\d t!Off'IPItting and 

revil'lw!ng tho ool!lIOfwn 01 inllHffitl\lon. Send: eO/fllTllll\I$ MjjMdinO 1M burd .. n utima\o Of any otmr a'pect of this oel/cation of lnfbtIDSllon, including 

turu;Mt.t{)m; lor radudf\\llhiJJ burdon, to Chiol, Information Po,ljoy Sr!lnllh, 1213&1. U,S. EnvirOnMental Protection AOfInoy, 401 tiiI Sfillet, SW, 

WlI'$hll\{lton, DC 1046(L 

INSTRUCTIONS; TN:t hrm is \0 be U§!)d for alillppliMtioM lor r'!bW (oQlslratJon, cnd U$O rer0olSl,Mion, OO'HIndment, r.submistion, to lIpJ)#eaUolW 

lor I1(lrifieouolW. final printod IIIb&!lfll). f(lfepilllflUlon, etc. In ardor Itl process on f4lpllelltlon for a new toa!,lrouon #I.IbmItted O'n thl" form, Ita 

following I'fWIlarfai niUst ae::omj:)MY Ihe appliominn: 

t. CortillGJil$)n with Rnpoct to Cl\lJllon 01 00111 IEPA Form &570·2SI. III nOlllXllmptlld by 40 CFR 152,81 /h) t41l: 

2, Confld6fldtil SWtom4nt of Formu!a IEPA Form 8570·4); 

3. fnrmuliltor', EXMI'Iption SUilcmenljEPA form 8570-27): 

4. five copiell 01 draft labofing: 

s. Thrall oopio. 01 MY dllte ,ubmilled; 

a. AUll\¢riutlon leiter wtWIl IIpplwilblll; 

7. MalricDS where Dflpfkable. 

,S",,,,,.,,hm 01 t..haling . l..ablillng 1Iih(HJ!d lirsl hi> tubrnined in lhu form 01 ({rftft !lfblll, wllh lIIIl $ppliellllioll$ lor I\IIW registrlltion. Such droft looo!s 

typed label te)(t on 3.5 x 11 inch paper lor mJbmh,:;lol1 or II mockUp of tM propoSlld lab&!. If (neplJred for mockup. it ahould be 

;:::~:~:~:~iiil way Ifll< 10 fl/llllillilil stoma. in lin 8.5 x I t iw.:h file. Mcekup labels sigt'lHieantty sm&l!llr IhM 8.5 X 11 Inch" should be1'rn:xmhx{ on 8,5 

fM $ubmlstOOn. 

of Olte • Oalil IllJbmiltad ill !;UPport 01 rl~s epplielllion musl be lluumittlld in ae::ordon::o wllh PR Nolioe 80·5. e l~fl;£lE!l:,lli~:!l.!1i;]JIQ!il!; pjll:l$1! r<!(lt! tha inStn)¢lloll$li${ed I.HlIOW bdore ccmplOlinglhis appUcarion. First delermine tfa twa of ttlaiglfeUOn 

A. lor wive!'! you Ute ,ubmltling Ihill application. For applieationll submitted in oonnection wIth New Registration ootiO"', Se(;tiam 

!V muSI blJ eomp!elll'd by 111$ applk:Mt. For I.lPPlic(l\1oml §ubmit\ed in conMotJon with GITlllnd@dreregislral!,,"OelioM',f$,ubmtcs{on8. 

1~"ilj""lQ"" rerIlQi$trlllinn" ate .• S~tllionll!, U, and IV moll! bo ::OInplaled bV rhllllpplielUlt. 

A • Check tJIC nppr"pri<l\!:1 aOlion lor whh:;h you @ro $Ubmlttino thi!J 10flTl, 

1~!£j;;:rJQ!il' This =<lllllon muU bo ::ompI"IfU!, 4$ apph'c .. tM. for nil rl,lQis:UiIouon ~tl<Jm:, 1. CQfftfHmyiPl';,ducl Numb.r· IMen your Compllny Numb!!r, If orno hlilt bean allwiuood by ePA. Thl, numb!!r may havo baen 1II,lIigMdlo Y¢1J allJ 

bUlo rllghmant, III disrribulor. or m. an esrl!b!i5hm~'"t. II your product!9 regilllerod, Ill1Iort Ih. Proouct Numbar. 

2, EPA Ptoduel MIIIMGM ~ 1/ k-noWfi, lill in lhti 'n/llua lind I'M numiHlt 01 the ErA f'roduat Manager. 

3. Propoud Cta!!ifIcatlon ~ Spocify 11\" propO~$d ellluifiellUon nf lhit prOOuct. 

4. Pfo/fucl N.rne· Enter tM ecmplata proou(ll miMe of this pulicide I1S It wj!lllppur on 1M IlIbM. Tfa nama roo$1 be' spedflc t(llfill producl only. 

OupIkatlo:n of Mf11<1a Is 001 PIUmitled llmong prodtwlli of Ih" Salmi company. 00 nol irn:dudtl any brand MOW {)f eomfHmv Umfd~thms. 

5. Namo end Addr ... el Apr»ieant • The name of 1M firm or pMlIon 1.Ind e<!dfuS IIlwwn In your IIf>P~Cillh:," hllta pertlon ot fum to wru:.mlh. 

U1Wfi'uauan win bo h'lIuDd. If you oro Il<lting in bahnll of I'Hl¢ll\or porI\', you must lIubmllllulMrilatlon Ir~ IhlJt porty U, oct f'Or 1hllffj in reghltrallon 

tnlilww. An IIpplil:~flt not l11llldl!'li} in Iha Unilud Slutes must hllve lin lIulhori:uid lIQont r01l!ding In the Unlled Siallll' to &Ot for them in llR 

regi51ra\ion mallors, Tho name and ct.l'fl1!l!.le Il'm!lIng edQ"rll$!l of $\.l::h an n{ltfll mulll aacomp"nr till!> epplle1.ltitm, 

6. ~dl~d ReliWw· F!FRA s!l:IlUon 3 lel3 l6i prOvidl!lI for iJxpedilH rovi"w of appljeutiof1# for rcgiS(flllion. Or trmall1,fnuln18 to '~'~"'!"~''':" 

that IV. lIlmifor OIldul'lt$(:IIIIIO orher pltMicWe producta that ore currently t'1Jgistcf!td with the EPA, In order for ytlUt llfiptloeoon te 

c.tpmhtoo reviow. you mullt pro0de us with IIHi' EPA RIlj)islrMion Number and product nil!'l1l1 of Ifwj- produet you ileuM Is: .imilar ""w,""", 

'fOllr product. The product mullt b, simifM or iden1ical1n holh lomwlation <100 lalal&d US$$. 

1, Subject of lI;ubmiJIalon • Chllck Ihe upp:J¢o!)le bfoek and provide: tho Aoency IMler dOlO If 4pproprlate. Provld. 16 bria' oxph.nation of Ih1ll pU!"fW#oitl 

for the: lmhmiulon, such as "lila addition 01 II tiro, pesl or orop l$poeifyl-; wwmtnd 1M- Conf(domii>l Slolllnwnt 01 Formula by ... ·: wrerogi$trllliion 

wbmilllliol'l"; "gtMrnl Inbel revi5ion of U5e dir:eetlon$," Allneh" Separale; p* il oddiUonili 'pace !$ MOOed. 

~~!!i~~~ jPaCKoglnq lind Conllil(lOf !ntormarkmJ- TfU$ Seotion musl be ::i>mpIoted for allapplieatlont; =ulmilllod in eonMctlon with now 

or epplieabltl amendmenl$', 

TYIUt cot Paellil;;"; - Chock the approprillie tJloek If y(Rlr pro>dw::1 wi!1 bo pa::kaged in the indiealed paekliQing typOt. 

lndieala thll $l'zo of Ino iOOhridual plfckol. and numlmr per r(lloll cont41Mr. 

Typo of Retail CbntJm.t· IndlclIl. typo 01 containtH In whloh producl wiN bl! mmeleU, 

lnclllhm of Nel' ~nlents - !ndhlate 1M localion of rlla nul eonl .. nUl in/nrrmltion for yetlr product. 

SiNic}.of flotllil C0fI1l1in«' Specify Ihe flol contel'lls of WI relail oonloinelll fot your producl. 

LCHlellon of USi! O~cliotlll -Inc!!::ol(l IhlJ location 01 Ihlt use dirllclloml lor ynur produot. 

MaM4»' In which lobo! is affi~.d 10 produet· Indlel'l(ed 1M melhod produel111blll j$ attached 10 r$lail ::onl.ciMr • 

. S~I·.XplamlIMy. 

EPA U,e Only. 
• 

• 

Date of IlOOl.ic:aUa'l _____ _ 

~ of Product PRF;ptm n;;Qod l':;t.benhQQ for; CQt too ann Tobaccn 

P. O. 110% J.2014 

Reseilcch Tdang ~~ Park! NC 27709 

1. 11115 application is ~ by all data subaitted or cited in the 

IR)lieation. In addition, if ciu-all op1:.1QM are indieaud. this applieat.icn 

is BUCp:)r'ud by all data in the Jqencyl S tilM thAt. concern the prcpertles 

or ettecu of this croduct. or of anv other cro:hlct:. that is idenucal or 

sUDltantially similar. and th.I.t is OM of the CypetI of data thn wculd be 

required 'to be sutmitted if this applicat.1cn ICUQht the initial reqistration 

of a p:oduc:e of ident.ieal or similar oq.-it1m and intended. IJSH under 

the data requinment:.!1 in effeet; a\ the date of apptCNal of tfUs awlic.ation. 

2.. r certify t..'wt, for each Study cited in ~ of this application 

tor registration ehat is an exclusive us. at:Udy, I have obtained the 

writun ~tmiUlon of t.'" Or'xqinal data .ut:mltter to elta that studv_ 

3. I certify th.It. for eaet'l study cited in supcon of this colication 

for reQ1Suation t.hat. is not an exclusive use uudy: - I have obtained tl'!~ written pemiSSicn of the original. data su.t:mitUJ:.n 

to cite th.at so.x1y: S. t9 

I t have nexified in writ1nJ the ctI'IIpanies who have lI'1.Itnitud r1au I haVe 

cited to sutII::IOn: t."tis a1)p.lieat.ion and h&v. offered to: (a) p.y COI~~t.ion 

fO\" "'-" data in.=- with """"1",, 3(0)(1)(0) antll(c)(2)(0) ¢ 

the _ra1 I_Icicle. FIIIlqidcle and _icicle l\ct, ..., (b) CUo_ 

negotia.tia"l.li to detemino \ll\ich data an SUbject to the (£4t6IW,&t.ion ~ 

requit •• nt. of tIm ard the eount. an:I tams of cu1C*ns&tion duef if 

&rtf. 'l'M ~es I have not.ified an: (Oeck awl 

{x.l All ~i" listed a'l the Pesticic1e Dau Sut:Ditters tJ.at for 

.t.ll acti,,,. ir¥1Adient.S contained in my prodUce (Cit......u mHbOd or 

cit ..... U option wder Selecti" Met.hex!.)-. (Also sign 'the General 

otter to Pay SUt.B'ftent c.lcw.) 

r J 'IIlOM ~i .. _ """" _<ted the otutliea which I have 

cit.ed (S6lect.ive tllltthrxU 

Date 1I?'9/97 

General Offer to Pay: t huetJV offer arJ!: aqree to -pey Wi\MllUdon. to 

Od\tIr pat'1lCl'lS, with nqarct to the epc::a:oval of this a;IIplieat.icn .. to U\e 

onent roquired by FImA NC. 3(e)(1)(D) an:! 3Jc)(2)(~. 

Siana=- /M/~d( 

TiUe 

(A!>r,l 1985) 

Gai.J Povel 1 

RegIstration Manager 

88 
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• 

RH6NE·POUlENC AS COMPANY 

EPA Correspondence No, GSP/elh!040 

January 31.1997 

U.S. Environmental Protection Agency 

Office of Pesticide Programs 

Document Processing Desk (H7504C) 

Room 26M. CryStal Mall 2 

1921 Jefferson Davis Highway 

Arlington, VA 22202 

Attn: Ms. Cynthia Ciites Parker (Pt-.-1 No. 22), 

... . '. 

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••••• 

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". . • • •• 

RE: PrcpT.\f brand Elhephon for Cotton and Tobacco (EPA Reg No,: 264-418); Label 

Amendment 

Dear Ms. Giles~P,'lIker, 

I am sHbmilling five copics of a revised PREpTM brand Ethephon for CottOil and Tobncco 

label. Please \Iote this label also contains revisions which \vere submitted to the Agency 

in January. 1996 itS pan of the Ethephon reregistnnion process. The January 1996 

revisions have not yet been approved. 1 have highlighted the new proposed label 

revisions on one copy of the submitted label. 

The following chimges hnve been made: 

"Tank Mixtures with DcfoHants and Insecticides" Seclion: 

Added Dropp@ Ultra r.\I and Ginslar® to the list of products. 

"Directions for Use Section": 

COllon Tahk: "Spmy Volume" column: Changed title to '"Minimum Spray 

Volumes", 

Added footnote: "For nest perfonnance by ground or air applicarion, chouse 

eAluipment and spray volumes thilt will insure unifonn coverage of foliage ;lIld 

bolls" 

'"GSOK \;Sl~·: 2 rw ALfXAJ;"<'iH i:ll"JL 

l<f;;r AI'lei i THIN,(;t.f !'Nll( t-) r: ?/;'('1-;::14 

(!:JJG)5{1l·;?Jfl) 

Excellence In Performance 

Pnde In AchJevemenr IlHfJmNI()flAt 1[1 ex hutAfiH1 ,b~()TU Ai r;,Yii'Ri',ACf; A,,-~ ;-ui"' 

IlflfHHAl{(JNAL D;g,RIGuT\CN SHMCfS- rL~ EX nUl-.l8fA ~9'Ynn-·Mb'i,i_PBAC" Ai'\': '11:', 

89 
. ' 

• 

• Deleted upper limits for all spray volumes. Changed spray volumes from 15 to 10 

gallons/Acre for PREP'I'M, PREpTM + FOLEX® and preconditioner treatments. 

"Use Limitations" Section: 

Added statement to address small grain intercropJling. This statement allows for 

planting of small b1fains prior to or immediately following harvest for soil erosion 

control if wheat is not harvested or grazed, The statement lIsed was modeled after 

a similar statement on the AgrEvo's Dropp®UltraTM label which is EPA approved. 

I have attached an article "Terminated-Wheat Cotron Best Texas Drought Option" 

from Cotton Fanning Magazine. l1!is article explains rhe practice of terminated 

wheat-cotton production in Texas. In Texas, wheat is commonly planted in cottOIl 

fields prior to or immediately following han'cst for soil erosion control. This is " 

practice developed. and recommended by the USDA. The current label restriction 

would prevent [he use of this soil erosion COittrOJ practice ill PREplM treated 

fields. 

Tobacco Table: 

"Spray Volume" column: Changed title to "Minimum Spray Volumes". 

Deleted upper limit'> for aU spray volumes. 

"Limited Warranty and Disclaimer" Section 

Corrected typographical error in last sentence of warranty and disclaimer 

statement. 

Added footnotes for Dropp® UltralM ;md Ginslar®. 

I have included the following fonus: CenificaJion witli Respect to Citation of Data nnd 

Application for Pesticide (8570·1). 

Thank you for yonr help on this amendment. I <:an be reached at 919-549-2687 if yon 

have any q1lcstions. 

Si,ry'Y, /i/JILL! 

Gail Powell, Ph.D. 

90 
PREpTM brand Ethephon 

FaA COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Ethephon (2·Chloroethyl) phosphonic acid' .................... " ...... ""."" ..... " ... "" ..... 55.4% 

INERT INGREDIENTS: ........................................................................................................................... 44.6% 

aThis product contains 6 pounds elhephon per gallon. 

EPA Reg. No. 264·418 EPA Est. No. 264·PA·01 

KEEP OUT OF REACH OF CHILDREN, 

DANGER PELIGRO 

5i usloo no ontiondo ta &Ilquela, busquo a alguion para quo so la exp!iquo a uslod en delano. 

(If you do nol understand tho laba!, find someone 10 explain illo you in detaiL) 

e For MEDICAL And TRANSPORTATION Emergencies ONLY Call 24 Hours A Day 1·800·334·7577 

For PRODUCT use. Information Call 1-800-334·9745 .:l,~t::'; 

Tho US8 of this product for a varioty of ptant growth rogutalion uses are protocted by United Siaies and loroign patents including" ".1 

U.S. Patent 4.240.819, No liconso is granted to use this product in countries other than tho Unitod Stales or for any use not 

contemplated by this labol. Liabilijy for patent infringement may result lrom uso or sale 01 this product outside tho Un~ed States, 

/ STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyelids open and flush with a gentle stream 01 waler lor at loast 15 minutes. Get modical attention, prolerably an 

ophthalmologist. 

IF ON SKIN: Immediatoly wash skin with plunty of soap and water. 

fF SWALLOWED: Do not Induce vomiting. Promptly drink a largo quantity 01 milk, egg whites, golatin solution or if tho$o are not 

available, drink largo quantities 01 water. Avoid alcohol. Call a physician immediately. 

IF INHALED: Remove victim to fresh air. If not broathing, give nnlliciat rospiration. Administer oxygen il necessary, Get madical 

atlention. 

.ANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS :±i 

PRECAUTIONARY STATEMENTS 

CORAosrvE. CaulI&s eye and $kin damage. May be latal if aDsorbed through skin. Harmlul if swallowed or inha!ed,)Avoid breathing 

SfJI'ay mist. 00 not get in ay05, on skin or on ctothln9;/"p a~~yIrom ,~~mQstic ani~als. '" J ,1 --""-

;,>NOTE TO PHYSiCIAN ~ \J~"J ~J,-,"j", ~,.-;-J f ~!t""fo--~l«,,,, j " 

There is no specific antidote, An troatment should bo based on obsorvoo signs and symptoms 01 distross in thO' pall_e~t. Ovar~posure 

to materials othor than this product may hava occurred, 2_", ' -, Victims of savare overexposure, by inhalation, should be kept under medical observation for up to 72 hours lor delayod'onsat of 

pulmonary edema, In a victim 01 over·oxposuro by ingestion, carolul gastric lavago is reqUired due to tho possibmty 01 stomach or 

osophageal perforation. This material is an acid, but uso of alkaline s~bstancos 10 neutralize il is contraindicated, 

v 'PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and other handlers must wear coveralls ovor short-sleevod shins and short pants, waterprool glovos, chamlcal·resistant 

footWear plus sockS, protactive oyewear, chemical· resistant headgear for ovarhoad exposuro and chemical-resistant apron when 

cleaning equipment or mixing and loading. 

OiSC3ld clothing and olher,absorbent materials thaI have been drenched or heavily contaminated with this products concentrato. Do 

not rouse them. Follow manulacturer's instructions for cteaning/maintaining PPE. If no such inslructions for washable!>, use detergent 

and hot water, Keep and wash PPE separately from olher laundry. 

When handlers use closed systems, enclosed cabs, or aircraft in a mannor that moets tho roquirements listed in the Worker Protection 

Standard (WPS) lor agricu~ural pesticides (40 CFR 170.240 (d) (4·6)]. tho handler PPE requirements may be reduced or modified as 

specilied in the WPS. 

91 
User Safety Recommendations 

Usors should ~ash hands bolon) aating. drinking, chowing gum, using tobacco or using the loilo!. .)1 

USGrs,should romov. dOlhlng immodialo/y if pesticide gots Insido. Then wash body thoroughly and put on clean dothing. '\ ;: 

( <Use~ should removo P.PE immooiatoJy after han?Hng this product. As soon as possibJa. wash thoroughly and chango into clean p. , clothing. Wash tho outside of glovos beforo remo .... mg, t, / 

ENVIRONMENTAL HAZARDS'/ 

Do no! apply dirodly 10 water, or 10 arona whore surlaco wator Is present or to intol1idal areas bolow tho mean high water mark. Do nO! 

contaminate water whon dIsposing of equipmont washwalor$. 

00 not contaminate walor used for irrigation or domastic purposos. 

SPRAY DRIFT 

A .... oid spray drift. Do not apply when woathor conditions may cause drift. Do not allow this product to drift on to non-target areas. Drift 

may result in illogru residUes or injury to adjacent crops and vegot3tion, in the form of leaf yellowing and defoliation. To a .... oid spray 

drift. 00 NOT apply <lanally when wind speod Is greator than 10 mph or during periods of temperature inversions. Uso of largor droplet 

size wIH also reduce spray drift. 

AVOIDING SPRAY DRIFT AT "THE APPLICATION SITE IS THE RESPONSIBIUTY OF THE APPLICATOR. 

'-' The intoraction of many equipment-and·weather-rolatod factors determine the potential lor spray drift. Tho applicator is responsible lor 

considering all those factors when making docislons. _The lollowing drift management requirements must be followed to avoid oll·targot movement from aorial applications to agriculturallield 

crops. These requirements do not appty to lorestry applications, public health uses or 10 applications using dry lormulations. 

"'1. Tho distance of the outor most nozzles on the boom must not excoed 3/4 the longth 01 the wingspan or rotor. 

l2." Nozzles must always point ba<:kward parallel wilh the air stream and never be point ad downwards more than 45 dogrees. 

:' Where stales hav. more stringent regulations, they should be obsorved. 

t The applicator should be familiar with and take into account the intormation COY/Hod in the Aerial Drill Reduction Advisory bolow: 

AERIAL DRIFT REDUCTION ADVISORY 

:/rThis section is advisory in nature and doas not supersede the mandatory labol requirements]. 

/fNFORMATION ON DROPLET SIZE 

Tho most ellective way to reduce drift potential is to apply large droplets. The best drift management strategy is to apply the largest 

droplets that provldo sufficient coverage and control. Applying largor droplets reducos drilt potontial, but will not pro .... ent drift if 

applications aro made improperly, or under unlavorablo I)nvironmental condillons (Seo Wind, Tomperaturo and Humidity, and 

Temperato/e Invors!ons). ' . J 

'-"CONTROLLING DROPLET SIZE \ ~~ 

Volume - Use high flow rato nozzles to apply the highest prac!ical spray volUme. Nozzles with higher rated llows produce larger ~ "roplets. ~ 

~r."ure - Do not exceed tho nozzle manufacturer's recommended preS$;lJres. For many nozzle types lowor pressure produces larger * 

droplets. Whon high&!' tlow rates are needed, use higher lIow rate nozzlos instead 01 increasing pressure. 

Nomber of nozzles - Use the minimum numbGr of nozzles that provide unilorm covQrago. 

Nozzle Orientation· Orienting nozzles so that the spray is relea.sod paraUol to tho airstream producO$. largor droplets than other 

orientations and is the rocommended practice. S!gnificant deflection Irom horizontal will reduclJ droplet size and Increase drill 

polenlial. 

Nozzle Type· Use a nozzle type that is designed for the intendod llpplication. With most nozzle typos, narrower spray angles produce 

larger droplets. Consider using low·drilt nozzle!!. Solid stroam nozzles oriented straight back produce the large!!t droplets and thlJ 

lowos! drift. 

".BOOM LENGTH 

For somo uso patterns, reducing Ihe ellactive boom le-nglh to less than 3/4 of Ihe wingspan or rotor IlJngth may further reduce drift 

without redUCing swath width. 

"'APPLICATION HEIGHT 

Applications should oot be made at a height greater than 10 faet abo .... e the top of tho target plants unloss a greater height is reqoired 

for aircraft safoty. Making applicalions at tho lowest height that is sa!!) reduces exposure 01 droplets to e .... aporalion and wind. 

,SWATH ADJUSTMENT 

Wh~n applications aro made with a crosswind. tho swath will be displaced downwind. Th&reforo, on the up and downwind ooges 01 the 

field, tho applicator should compunsato for this displacement by ad;usting the path 01 the alreralt upwind. Swath ad;ulltment distance 

should Incroase, with incruasing drift potential (higher wind, smaller drops, atc.). _____ 

92 
WINO/~ 

Orift potential is lowest betwQon wind spoeds of 2· 10 mph. Howevor. many factors, including droplet slzo and equipment typo 

determine drift potential at any given speGd. Application should be avoided below 2 mph duo to variable wind dIrection and high 

inversion potential. NOTE: Local terrain can inftuenco wind patterns. Every applicator should bo familiar with tocal wind patterns and 

how ttley affect spray drift. 

,-,TEMPERATURE AND HUMIDITY 

When making applications in low retativG humidity, set up equipmont to produce targer droplo\s to compensate for evaporation. Oroptot 

evaporation is most seVCUG when conditions aro bolh hot and dry. 

TEMPERATURE INVERSIONS 

Applications should not occur during a temperature invorsion oocau5o drift potential is high. Temperature invorsions restrict vertical air 

mixing, which causes small suspended droplots 10 romain in a concenlratod cloud. This cloud can move in unpredtctable dirOClions duo 

to the tighl variable winds common during inversions. Tamporaturo invarsions are characterized by Incraasing temperatures with 

ahltude and aro common on nights with limited cloud cover and light to no wind, Thoy begin to form as the sun sots and often continue ) 

into Ihe morning. their presence can be Indicated by ground tog; howevnr, ff log is not preSfant, inversions can also be idantifi&d by the~ 

movomont 01 smoke from a ground source or an aircraft smoko gonorator. Smoke that layors and movos latoraJly in a concentrated Y 

cloud (under low wind conditions) IndicattJS an invorsion, while smoke that moves upward and rapidly dissipates indicates good vnrtical 

air mixing. - , 

",SENSITIVE AREAS ~ 

The peslicide should only be applied when the potential lor drilt to adjacent sensitive areas (e.g. residential areas, bodies 01 water, ~ known habital lor threatoned or ondangored spedos, non-targot crops) is minimal (o.g. when wind is blowing away Irom the sensitivn 

eareaS). ~ 

vUSE PRECAUTIONS 

Do not apply PAEpN brand Ethephon lor Cotton and Tobacco through any typo of irrigalion system. 

Avoid spray dr;ft to nearby crops as this product wiU cause modilications in plant growth. Planr injury or reduood yields will result, 

Mix only the amount of spray you oxpoct to uso each day. Do not allow mixod solution 10 sland ovornight. 

DIRECTIONS FOR USE 

It I. a violation 01 Fedoral law to us. this producl In a manner InC1:lnslstont with Jts lab.llng, 

,Read entlra label bofore using this product. 

r-~~~~'w. =~------~ 

apply this prodvct in a way that will contact workers or other persons. oither diroctly or through drift. Only protected handl"l 

in the area during application. For any requirements specilic to your State or Tribe, consult Ihe agency responsible lor 

regulations. 

only in accordance with its labeling and with tho Worker Protection Standard, 40 CFR part t70. This standard contains 

for the protoction 01 agricultural workers on larms:, lorosts, nurserios, and greenhouses, and handlors 01 agricultural 

It contains requirements for training, docontamination. notification, and emergoncy assistance. It also contains specifIC 

and oXCGptlons: PtlMaining to the statemonts on this label about' porsonal protective equipment (PPE), notification to 

and restrictod-ontry Inlorvals. Tha rGquiramonts in this box only apply to uses 01 this prodUel that are coverod by Ihe Workor 

Slandard. 

I Do n~1 enter Of allow worker entry into troated arna$: Quring the rostricUld·enlry intorval (REI) of 48 hours. (The AEI is 72 hours in aroas 

avorage rainfall is loss than 25 inches per yoar.}./JUJ; ~ ',-' / , 

anything PPE required that has lor early b~en entry treated to treated such as areas plants, Ihat soil is' or permiltod wator is under coveralls the Worker ovor long-sleeved Proteelion ;'i:~~:~~~~:~~},I~:~:~~;~:t~~::~~~\t such as any)watorproof gloves. chemical resistant footwear plus socks, and 

I i headgear is also requirod. 

93 
STORAGE' 

00 not contamlnato walnr, food, or food by 510rago or disposal. 

If contalnor is brokon or contonts have spHIod, follow alt procautions indicalod above and ctean up Ii', '~:,?:i~~~'~~I,~;~~;~i~:~i~~:~ I 

on fulliongth trousers, long sleeved shirt, protoctivo gloves, and 9og9les or laco shtotd. Soak up spitt with 

I ,::.:~!~~.a::rth or other suitable mahlrial and disposo of wMte at an approvod waste disposal facUity. 

DISPOSAL 

wastes are acutoly hazardous. Improper disposal 01 oxcess posticido, spray mixture, or finsalo Is a violation 01 Foderallaw. 

wastes cannot be disposed 01 by use according to label instructions, contact your Slate Pasticido or Environmenlal Control 

~~:,rA~o'~r,tt:h:~O Hazardous Waslo roprasontalivo altho nearest EPA Regional Offico lor guidance. 

DISPOSAL 

rlose (or equivalent) the empty containllfS. Then offer lor recycling or reconditioning, or punctum and dispose 01 in a sanitary 

or by incineration or if allowed by stato and local authoritios, by burning. II container is burned. stay out 01 smoke . 

• - REFILLABLE CONTAINERS 

rotum thO cootainor to the point 01 purchase or dosignated locations. This container must only bo "Ililted w~h PREPtl( brand 

lor Cotton and Tobacco. 00 NOT REUSE THE CONTAINER FOR ANY OTHER PURPOSE. Prior to relftling, lrn~!',oc'l 

lor damage such as cracks, punctures. abrasions and damaged or worn outthroads on closure devices. Do not 

leaking containers, Check lor leaks after refilling and belore tltho container is not baing reWled. 

INFORMATION 

VC:OTTON 

A loliar spray 01 PREPN brand Elhephon lor Cotton and Tobacco will accelerate opening 01 mature unopened cotton bolls and enhance 

dolo~ation which can rosult in earlier harvest with an increased recoverablo yield. PREprn tmatment on cotton allows increased 

efficiancy Irom a once-over harvest. 

J'tOBACCO (FLUE-CURED): A lotiar spray 01 PREpN brand Ethephon promotss early, uniform "yellowing- 01 matur~ tobacco. 

PREPnc roducos curing time, allowIng more efficient use 01 curing barn space, and increased control over harvest schedules. 

/$PRAY PREPARATION 

Add 112 to 314 ollho requiroo amount 01 water to the spray tank. Start agitation. Add Ihe required amount 01 PREP7lI brand Ethophon, 

and the remaining amount 01 water. Prepare only as much spray solution as can bo used on the day 01 mixing. Do not allow spray 

solu1lon to stand overnight. Do not split the concentrated product on spray oquipment. or any airplane parts, 

ANY SPILLS SHOULD BE RINSED IMMEDIATELY WITH PLENTY OF WATER. 

Usa 01 a nurse tank is highly recommended lor avoiding possible spillS 01 COflC9nlralnd lormulation on spray aquipmont or any airplane 

parts . 

. ~ANK MIXTURES WITH DEFOLIANTS AND INSECTICIDES 

."REPN brand Ethephon is compatible with DEF'. FOlEX'#. Dropp2, Dropp1}Ulfrarn2, Ginsta~2, Harvadlil· Methyl Parathion, Gll1hion', 

and Malatbion4• PREPN may be applied in sequeoce or as a tank mixture (00 NOT TANK MIX WITH DESICCANTS IF COTTON IS TO 

BE SPINDLE HARVESTED). Follow all applicable use pracaUlions and ralo por acre recommendations on labals 01 products applied as 

tank mix1ures or in sequence w~h PREP U< brand Ethephon. In somo cases slight roduction in bolt opening response has bean 

observed when tank mixes with oololian!s wore used. 

Good agilation In !hll spray tank is essential and 11 tank mixturo should not bo allowed to stand wllhout agitation lor more than 5to to 

minutos. Read and observe aU appropriate label use direction!> and pre-cautions lor the deloliants and insecticides used. 

NOTE: UNDER CERTAIN CONDliIONS, TANK MIXTURES OF PREpnc BRAND ETHEPHON WITH DESICCANTS CONTAINING 

SODIUM CHLORATE COULD RESULT IN THE FORMAT}QN OF HYPOCHLOROUS ACIDS WHICH ON HEATING WILL EMIT TOXIC 

CHLORIDE FUMES. 

DO NOT MIX PREPTloI BRAND ETHEPHON wlm AMMONIUM THIOSULFATE. SUCH TANK MIXTURES MAY RESULT IN FQRMATK)N 

OF TOXIC FUMES. 

;/tEOUIPMENT CLEANING 

Bllcause 01 tho acidic nature of this product, prolonged oxposure to spray d(lpos~ witt damage acrylic plastics. certain paints. and 

metals. 

Rinse thotoughly with a dlltllrgel1t and walDr all oxposed acrylic plaslic.typ{! matorials (o.g., aircraft windshiolds). and painted surfaces 

within an hour after oxposurG to spray doposils. 

At tho ond 01 each day, rinsa thoroughly wilh a detergent and water alt the metal parts 01 the aircraft and the associatlld spray 

equipment expo$Od to tho spray deposits. 

94 
COTTON 

USE" EXPECTED PREpTH ONE MINIMUM APPLICATION 

CONDITIONS RATE GALLON SPRAY TIMING 

PREpm VOLUMES 

I LBS AJ. Aere. Air .... 

PREpN Hot and dry gO°F or I 113 1.0 6 Apply when tho number of 

Boll Openo,·· higher mature unopened bolts is 

Dry and 75 10 BO°F 2 1.5 • 2 

suffldenl to produce tho 

10 desired crop. SOQ bGlow lor 

Cool but above 65"F 2213 2.0 3 lest of boll maturity, 

Treatment uniformly opens 

or bolls 710 14 days oadior. 

0, oil, 

PREpTII + High soil moisture 113 0.25 2. 10 5 Apply 4 to 7 days prior to 

FOLEX· or PREpm boll opening 

OefoUant Tank High ler@ty tevot application. To b& used as 

Mix··· a soquonliallreatmom w~h, or not in I PREpnl bott 

. Rank conon 

EPN+ Dropp High soil moisture 113 0.25 2' 10 3 I ~~~~_;_IO 7 days prior to 

oefollanl Tank High fortUity lovel bolt opening 

Mh,··· r To be used as 

Rank cotton I a :1 ~;.:R"!o~~ ~nh. nOI i~ pi:",. boll 

Pre-Conditioner Hot, dry. 213 0.5 12 Apply 4 to 7 days prior to 

for DefolIation COOl, aboYO 65"F 1113 1.0 6 10 2 dofoliant. Enhancos top 

or crop deloliation reducing 

dolerioralion of bottom crop 

Rank cotton and allows lor aarlier 

• Fat best performanco, by ground or air apphcauon, choose oqUlpment and spray volumes that Will Insura uniform coverage 01101lage 

and boRs . 

•• Pretreatment With Defoliants Prior to PREpn.o brand Ethephon Boll Opening Treatment: II the colton 

is oyorly rank or layIng down in tho mIddies and good spray coverage 01 tho botts with PREf'lM Is diJlicutt. a pretroatmont with 

~ deloUants witt be uselul to improve bolt covorage wilh PREpnI. Use dosago rates of PREpn< ro<:ommcnded for bott opening. Read 

and observe an approprratft labol use dirodions and precautions for the delolianl used. 

(can use up to lutt labol ralo lor each product) c-J,JC;;v~,,-

..... In California and Arizona use a volume 01 no loss than 5 gallons per acre lor aerial applications. 

/8011 Maturity 

A bott is mature when it is too hard 10 be dented when squeezed between thumb and lingers. toO hard to be sliced with a sharp knife, and 

when the seed coat bocomes lighl brown in color. 

Use Llmttatlons 

00 not exceed a maximum 012.0 lb. ai/A lor combined uses 01 PREpn.t brand Ethophon per acro per year. 

• Boll Opening: Do nottanl\: mix PREprn brand EltJaphon wiJh a desiccanl if the colton is 10 be spindle harvesled. 

• Pro-Condition lor Deloliation: Do not tank mix PREp1M brand Elhephon wilh desiccants unloss planl dosiccalion is required. Do not 

- /USD a defolianl before Ihore is sulficient maluro unopanod bolls to produce Iho desirod yield {SGO General Informalion section on 

,"/ how to test for bon maturity. 

00 NOT APPLY PREpnI BRAND ETHEPHON IF RAIN IS EXPECTED WITHIN 6 HOURS. RainlatJ within 6 hours of applicalion may 

roduco product performance. 

Do nol plant anolher crop within ~o days after trealmonl. Small gl{1ins planted oarlior Ihan I month or inlercropped wilh lho colton 

crop to which PREpw witt be appliad may only bo used as COYer crops and may not be harvosled lor lood or loed, PREpnI may 

cause yottowing and growth inhibition of Irealed smatJ grains. 

~~HEN TO HARVEST COTTON 

Do not harvest colton sooner than 7 days aftor a troalmonl with PREpm brand Elhephon. 

Observe Iho Irealed crop and harvest whon optimUm boll oponing has boon roached. Too early harvest mighl r"ducs tho full advanlage 

of tholrealmenl and 100 lale a harvest may resull in reduced quality and loss 01 lint which ¥lilt drop lrom Ihe planl. 

95 
Crop Situation 

Application 

Application 

PREpTU 

Pints/Acre 

1 1/3 

11(3-2213 

USE LIMITATIONS 

Spray 

Volumos 

Oallonsl 

50 

40 

TOBACCO 

SpecHlc Olr.ctlon. 

Use drop nozzles. ChooSB 

gpa at 35-40 psi and at tractor speed 2·3 

2 nozzles per row; one on each side or the row dropped low onough to dirOCf 

the spray to tho loaves to be ripened and harvested. Thorough spray 

i With a directed spray, bo sure to harvest all loaves 

; 

Troa! only whon leaves I 

remaining leaves ar. maturo, spray several 10t,.eeo 

described under the section ·Proper Time 01 Troa!mont: Usa the lower rate 

in a normally mature crop whon experience indicates that minimum ripening 

inducement is required. Use tho higher rato when tho crop is heavy and has 

a tendency to be more rank or when temperatures are lower than normal. 

Always test spray to detormine if tho tobacco is mature enough to respond 

to treatment with PREpm 

Apply ovor-tho-top PAEpl'" spray as a tine mist using: throo nozzles (ono 

nozzte tips over the canter of the plant, and one on oach side) $0 all leaves 

are covered thoroughly, similar to tho I 01 systemic sucker 

I 

Do not apply PAEpDI brand Ethophon to immature loaves as this clln result in unsatislactory coloring, woight loss and reduced loal 

quality. 

Do not allow the CfOptO ovor r'lpon 'In the tiold alter using PAEpu. brand Ethopoon. since this may causo somo roduction in yield and 

quality. 

00 not treat before anticipated major storm which could prevent harvest and res}l.It,in crop ~ss: .. ' . 

00 NOT APPLY PREpn.c BRAND ETHEPHON IF RAIN IS EXPECTED WITHfN\6,HOURS. "Rainfall Within 6 hours of applICation may 

i. reduce product periormance.) ;. jii~l~_ v....-~, ~ ", 

Do not use PAEPT"'lxand Ethephon with add~ivos other than recommendod on this label. ' 

Do not plant another crop within 30 days alter treatmont. /~;;"'/" 

Do not oxceod 2lbs othaphon per acre per year. .' 

vA'PPLlCA nON TIMING .'-

Successful results with PAEpn.c brand Ethephon call for treatmont when loaves are maturo, not ovorty rank green when sprayed. To 

ouily determine the proper troatment timing and the number of leavos per slalk ready for harvest, tost spray several plants in more 

..-..!han one location In each Held and observe the reSponse. Mature leaves will begin to yellow in 24 to 72 hours. Tost leaves that fail to 

.,.weflow In 72 hours are not mature and aro not ready for PAEpN treatment Wait'8 few days to permit lurther natural maturing, then 

make anothor to51 spray or -maturity- chock. 

To avoid quality 10$$ and or possible leaf drop. harvost an¥ yellowed leaves prior to application. Use lower rates under most conditions" 

limit use of higher ratos to cool (below 6SF at tho time of treatmont) slow rlponing conditions. 

Whon you have conlirmod tho desired numbor of leaves por plant that will color, you can dotermine the number of acros to troat in order 

to fill the bam. 

Preparo your test spray by mixing onetoaspoon of PREP1).1 brand Ethephon in t quart of water. Spray each test plant with abolJt t oz. 

of this mixturtl:, covering aU leaves with a tino mist. PAEprn will not co_lor immature sprayed leaves. 

tAYHEN TO HARVEST 

All maturo, sprayed loaves will begin to color within 24 to 72 hours altor PREpm brand Ethophon application. The yellowing procoss i, 

woather dependent; cool weather will detay, while hot, sunny weathorcat'l spood up the procoss. Harvast treated tobacco when leaves 

have reached the desired color inlensily. 

Harvest can commence 48 hours alter PREpm brand Ethephon application. To detonninQ harvest timing and avoid quality loss or loal 

drop, closoly monitor trealed crop and weather conditions. 

v,CURING PREpm BRAND ETHEPHON TREATED TOBACCO 

Curing proceduros are as much an art as a science and each curo must be judged on the basis of tobacco condition, Interval between 

troatment and harvest, woather and type of curing facility boforb prescription temperature and ventilation schodulos can be 

established. To obtain maximum quality, carl) must be taken to observe and control the curing process closely, espocially during the 

lalo ·coloring" and earty "drying~ stagos 01 the loaf. 

PREpn.t brand Ethephon treated tobacco will have started Ihe coloring process when harvested, reducing tho time required in tho 

coloring phase of curing, Treated tobacco shOUld be dried faster. If tobacco lea'lo$ are groen or contain some groen when harvested, 

it may be nGCGs.sary to color them lor a few hours. If the leaves are completely yellow. temperature and ventilation must b& adjustlMl in 

a manner to dry tho tobacco as fast as possible without scalding. Once tho loaf is dried (3/4 dry), you should follow normal procedures 

for curing. Since PAEpN troated loaves curo fastor, treated and untroated leavos should nol be cured together in the same barn. 

96 
LIMITED WARRANTY AND DISCLAIMER 

The manufacturer warrants (a) Ihal this product conforms 10 Ihe chomical description on Iho labol; (b) Ihal this product is reasonably fit 

for Ihe pUrpc.10S sol forth in Ihe directions for use whon it is used in accordanoo w~h such directions; and (c) Ihal Ihe dirGC1!ons, 

warn!{lg and olhor stalomenls on Ihis label am based upon rosponsible oxpons' oyalualion of reasonable 10siS 01 offectiveness, of 

loxicity 10 laboralory animals and 10 planls, and of residues on food ClOPS and upon roports of field experience. Tests have nol beon 

mado on aff vaoollo$; or in all states or under aU conditions. lliE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT 

AUTHtJRlZJ::. ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES, EXPRESS OR IMPLIED. AND IT 

EXP' ..... EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANT·ABILITY OR FITNESS FOR A PARTICULAR 

PUR }SE. 

THIS IARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR 

DAM~ iE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRi .OOS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES. OR INJURIES RESULTING FROM THE USE OR HANDLiNG OF nilS PRODUCT, WHEniER OR NOT BASED IN 

CONTRACT. NEGLIGENCE, STRICT LIABILITY IN TORT OR OniERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTION, 

TO REPlACEMENT OF, OR THE REPAYMENT OF THE PURCHASE PAICE FOR, THE QUANTITY OF PRQDUCTWlTH RESPECT TO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SelLER BE LIABLE FOR SPECiAl INDIRECT OR 

CONSEQUENTIAL DAMAGES RESULTING FROM niE USE OR HANDLING OF THIS PRODUCT, WHEN USE OR HANDLING IS NOT IN 

ACCORDANCE WITH LAIlEL DIRECTIONS. 

NOncE TO BUYEA 

Purchaso ollhis product does not conler any rights under patenls governing Ihis product or Ihe usa therool in counlries oulsid$ 01 Ihe 

fltt'nil&d Siaies . 

• 

1 DEF and GlJlhion are registered trademarks of Bayer AG, G&rmany. 

2Dropp and Ginslar are regislerod trademarks and Ukra is a Irademark 01 AgrEvo. 

'Haf\lade is a registoroo lrad.mark 01 Uniroyal Company. 

~Malalhion is a Iradomark 01 American Cyanamid Company. 

RhOna·Poutone Ag Company 

P.O. Box 12014, 2 T.W. Aloxandor Drive 

RHoarch Triangle Park, Norlh Carolina 27709 

PREP is Ihe Irademark 01 RhOne-PoulenC. 

FOLEX is a registered trademark of Rhono-Poulenc . 

PREpThi brand Elhophon for Cot'.on and Tobaa::o (PENDING) Submitted 1116196, Resubmittod 1131/97. 

97 
, , 

-

• 

• 

I

N AN IRONIC TWIST TO THE CURRENT 

TEXAS DROUGHT, some cotton growers 

have shunned a moisture-conserving cultivation practice because they lacked irrigation 

water. But many who invested water in the practice this winter are benefitting from improved 

stands, fewer blown-out fields and potentially 

higher yields. 

6 COTTON FAAMING JUl..,.. 1!l96 

llYV1CKY BOYD 

The practice, called conservation 

tillage or terminated wheat-cotton, 

involves planting a cover crop of 

wheat or rye in the fnll after cotton 

harvest. The seeds are sown in 28 to 

30 inch!'!:; of the furrows and llides of 

·to-inch rows. i<~aving the top bllre. 

Grower;; allow the wheat or rye to 

tiller until two to four weeks before 

planting, when they burn it down 

with a herbicide such as Roundup_ If 

the wheat isn't tillerillg, it "mdt$~ 

aller the herbicide application and 

does not provide enough residue to 

hold the soil and retain soil moisture. 

Because the top of the bed is bare, 

growers don't need special planting 

equipment to slice through 11 cover 

erop. IU'IyS Wayne Keeling, sys~ms 

agronomist with the Texas 

Agricultural Experiment Station in 

Lubbock. Texas. 

The lack of top cover isn't h~rge 

enough to promote wind erosion, a 

common problem in part:a of the Texas 

Panhnndlo. Growers nlJro don't have 

to fight n cover crop regreening and 

compel,.ing with cotton seedlings, 

according to ~1ing. 

After cott~n harvest, growers plant 

wheat into the stalks. The cover not 

only trnps winter moiature but also 

holds the soil down during strong 

wind stonnS'. 

In Texas, heavy rains !!1ick over 

bare fields of sandy soil. When strong 

winds fnllow, topJroil is blown away. 

~Blow outs~ of entire fields. are not 

uncommon. 

A wheat or rye cover requires II preirrigation before pianting or irrigation 

Jor stand establishment. For thnt rea· 

Jlon, some growers opted against it 

lasl,. winwr l«auoo of low water supplies. 

98 
r 

• 

• 

TEXAS RAINFAU 

r1r the ; . .'ast tbree ~'cnrs, T~:;;a;; h,w 

received II;!~s-lfHtn-normal r,:unfull. 

The problem came to i1 head In law 

1995 when fall nuns never camt', 

The lr(lOd continued inti) 1996 with 

only scan~ ramfall in April and May -

normally the wettest month5 of the 

year, :\1any areas oi the l!.taw Cltli'gOrized as having 

~moderute uroughC 

conditions III l'!nrly 

1996 have neen 

reclassified as being 

III a severe drought. 

-Orought makes 

this less of a.n optIOn 

than what it might 

be uncler normal ctrcumstanccs,F 

K(Wling SIlYS, -:\lm;t people in the system are doing It under irrigahon," 

Ouring four yellrs of large-scale 

lield trials at Lamesa, Texas. conducted in 1991 lind from 1993 tll 199;3 by 

the Texas Agricultural Exlcn,~i(llt 

Service. terminatM wheat-colllJO had 

good yields (~ee bmo, 

Under drylnnd conditions, the U'r~ 

minated wheat·cott-on dldn't perform 

as well. with field,; yu;;lding a four~ 

year average of 234 pounds an acre, 

Conventional tillage yielded 249 

pounds an ocre and solid plnnting 

using minimum tillage yielded 364 

pfJUndll per ncrf'. 

IRRIGATION IS BENEFICIAL 

All things. considered. Keeling 

believes terminated wheat-cotton 

under irrigation is the best optioll, 

"Generally, Yields (of the termmat· 

",d wheat-cotton! have been equal to 

or n little bit higher than conventional," he says. "We have had three ttl 

four yellrs of below-average .minfllil,. 

and it still yielded equul to convenrionoL I think if we ever get back inw 

an uverage water year, that is whIm it 

wilJ renlIy t"1)me Oll.~ 

Alan Duncan, mdependent farm 

implement so-IllS representative based 

in Plainview. Texas, says terminated 

whellt-cotton is slowly catching on, 

espeeialJy in areas with sandy soil, 

~Jt's increaSing eVl'ry year nnd I 

think, oven with the drought. it's 

gaining.~ he ~ays, 

As many as 30 pcreent of the growers In the sandy solis around 

Seminole nnd Brownfield U!W a cover. 

But in the Lubbotk area where soill> 

are hl':'avler. ff>wer have adopted it. 

Duncan adds. 

Butch Harrell. who farms (lcnr 

Hale C~nt.er nonh of Lubbock. knows 

Ihe benefits of temunated wheat·co. 

ton. lIe h(l!! nbout. 122 acres planted 

with C()\'('r under c('nu>r-pivnt lrriga· 

tlOn. IIis r<!maming 2,10 acres are con-

.... entlonally tilled. 

A recent rainstorm dropped a 3/4 

inch on hiS fann, and two hours Inter 

Ihe sun came aut. "licking o~'er the 

!loil. The v.ind then liLarted blowing at 

50 miles per hour. 

"I lost tll"vcral acrcs (of convent!onal) hffausc the .... ind just blew it 

up," Harrell says. "But with the no· 

!ill. I dIdn't even worry about It.~ 

The rover also hal> helped save soil 

mOISture, In the fields WIth a good 

,~()ver, h" used his cuswmary 314 inch 

nnd had good stand establishment. 

Harrell. wh~'s been experimenting' 

with ",over crop!; find what he calls 

~no·ttW for the p!Cit five years, says 

the only drawback is the high cost of 

herbicides needed for burndown_ 

~You ha~'e to have an awfully good 

YH~ld to make it work - that is the 

problem. ~ he says. Two bllieli every 

year would be greal. But last year, we 

were happy to get 600 pounds.M 

.James Simpson, a cotton growf>r 

near Lubbock. decided not to plant a 

rover this win~ 

ter because 

well levels were 

half of what 

they were four 

yean ago. 

~l wiah I still 

had some 

wheat. because 

we would still have our crop," 

Simpson says. 

The same winds that blew out parts 

of Harrell's crop alro struck SimptiOn. 

who lost about half of the 480 acres he 

had und~r cMwr-pivot irrigation. In 

late Mny he was trying to replant. 

Duncan .says one deterrent UI grow_ 

ers have to plant a cover 00 late they 

may not get adequate residue production by the time they have to burn it 

down for spring planting. 
• U, EI'o'Vl1t«"ME... 'TAL I'ROTECTlON AGENCY EPA Rq: NuJnb<,t. l'>$ of rn~:mcc: 

:cI'rtO ""'>r". 

Off« rX I\$lki& I'rograrm 

P:'1:I!md~'~ PI,>jlOnlH7505Ci 264-418 JUl !7 1997 

;- ..,. ~ .u)! 'M" Sr . S W 

\~) W:o!ltin~t<m, 0 C 2~60 

T~mrM l!suMICc' Unconditional +»"t ,.,..,.tV 

NOTICE OF PESTICIDE, 

--- Registration 

_X_ Reregistration N>..'W <If 1' .. \1<',* I'm&'<;:I'Pl-ep brand 

(\;r>!kr Fll'ltA, ~ :tmrndt'd) Ethephon for Cotton 

and Tobacco 

NlI.IIlI' and Addr .. s <,r Rt~:1t.1;W (i",I~M 7JP C.-.k), 

Rhone-Poulenc AG Company 

P.O. Box 12014, 2 T.W, Alexander Drive 

Research Triangle Park, NC 27709 

Now. C~o ill bbdill; ditfmnt ill HlmW!Ce frnm Ilw lI(C~ in COOII«limI with II,n ~iMIIluo toUl;\ Ix- ~ul>lMkd!(l ~ 1Ii:tepfI:d by the Rql«flIIJOI'> 

Dr-Itkin pMr III \llt of!k ~I in romn><:ttt In:my t"'rC$~ 00 lhl!; ptl.>duCl.;lways I'C'fer 10 the lIho~,t EPA ~i1If/lliM numb« 

o~ th<: bti", m ;"I(>lTllllliun f~r()iI;htd by lhc Icti,trW., W ~ na.Ill<'>.J pcll>ci/k " hn.by rquttrw!rtttt,ll.:r«l undo" !be Ft<knllll;Oo;;lIdde. F\lIIjIO:id<: ... .<I 

R<xkntkKk ML 

• Rq:utnlWn Ii In 110 w~y to lK :00",:... '<1 $ "" mOOrn:mrr~ (>1 remmmcn.:I.Mmn M tho. P'OI.Iu« by the Ag~!:ICy. 10 onkr II! p''Jl'Xt ~th and!ht co.;ujtlJl)CnI, 

Iht Adll\ll1isrr~r. on hi:! IOOOiJO. !Ny !II ""y rime !wpmJ (>f wc:llW: rqarratiM of l palkKk in acC<l~ with the Ao. lbc- ~tptaOCc or My rwnc In 

conr.eaiM with ~ rOii>lr.iIion of ~ P'oo:i1lct un<ltr ill" A<I i~ 001 10 W oo"'tnJ~d .. iivm~ Iht rttlSUiII\l ~ rijl" ru "dmj'e UI<; <If u.. name« l<) ir$ usc if 11 

Iw bo:r. ~o\tr~d by lXhr.. 

Based on your response to the Reregistration Eligibility 

Document, EPA has reregistered che product listed above. Enclosed 

is a copy of your label stamped "Accepted, " This action is taken 

under the authority of section 4 (g) (2) (c) of the Federal 

Insecticide, Rodenticide Act, as amended. Reregistration under 

this section does not eliminate the need for continual 

reassessment of pesticides. EPA may require submission of data at 

any time to maintain the registration of your produ(.'t. 

: . 

• 

Sigrw-.. re or App",.,-ir,g O(fi"ral DiU: 

1!' i7 1997 . , 

"rm 'I\H) 

100 
PRE P TM brand Ethephon 

FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

•••• ACTIVE INGREDIENT: Elhephon (2~ChloroethyJ) phosphonic aCId' ..................................... "" ........ : •.... 55.4% 

INERT INGREDIENTS: ................................................. 0< ................................... , ••• -.~~.~;~.:. •••••••• ,. ••• ~ •• ,,44.G% . . . . 'This producl contains 6 pounds ethephon per gallon. 

~ Reg. No. 264-418 

•••••• • • 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

SI usled no enliende la eliqucln. busque a alguien para que SI! la expltque a usled en delalle, 

(II you do nol understand the label, find someone 10 explain It to you in de/ail.) 

•••••• • 

• 

• •• •• ... • , 

••• • 

•• .. 

.FF'iio"rlMi:iE~DiiIllc~A~LClA\ini<dI"TIBMA1iN~Si1pgOl]Rii:TIAA1T]IQQijNEE;;m;;;e;:;rgg;e;;niCcT.;.;;.i"i:QlINUL::'y[(c':i.iill"l 2244iH:r.o;iuJrr:ss~AAiD5i.;;yi11:;·.iiioiOo::·3ii3i44:j·7'55"i777-

For PRODUCT!lS..E. Information Call 1-800-334-9745 

The use 01 this product lor a variety 01 plant growth regul<lHon uses are protected by United States and foreign patents Including 

U.S. Palent 4.240,819. No license is granted /0 use this product in coull/ries other than tho United Stales or for any use nol 

contemplaled by this label. liability for patenllnlringumenl may result from use or sale ol/hls product outside the United Siales. 

FIRST AID 

IF IN EYES: Hold cyelids open and /lush with a gontle Siream 0/ water lor 1I1Ioa51 15 minutes, Gol medical attention, preferably an 

ophlhalmologist 

IF ON SKIN: Immediately wash skln wilh plenty 01 soap and water. Get medical altention. 

IF SWALLOWED: Do not induce vomiling. Promptly drink a large quantity of milk, ogg whites, gelalin solulion or illhase are not 

available, drink largo quanlities 01 water. Avoid alcohol, Call a physician or Polson Control Ccnler. 

NOTE TO PHYSICIAN 

Treat symplomalicnlly. Consideration should be given to Ihe possibility Ihal overexposure !o materials olher Ihan Ihis producl may 

hnve occurred. No specific anlidote is available. Probable mucosal damage may contraindicale Ihe use 01 gastric lavage, 

• PRECAUTIONARY STATEMENTS DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. Causes irreversible eye damage and skin burns. Harmlul il swallowed or absoftlod through skin. Do nor gel in eyes, on 

skin or on clothing, 

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and olher handlers must wear coveralls over short-sleeved shills and shorl pants, chemiCa!·resislanl gloves (such as 

Nilrile, Bulyl, Naoprene andlor Barrier Lamlnale), chcmical'resislant loolwenr plus socks. prolective eyewear, chemical·resislanl 

headgear lor overhead exPosure and chemical·resfstanl apron when Cleaning equipment or mixing and loading. 

Discard clolhlng and olhor absoftlent malerials that have bean drenched or heavily conlaminaled wilh Ihls producls concenlra!e. Do 

not reuse Iham. FollOW manufacluror's inslruclions lor cleaninglmainlaining PPE. II no such fnslrucllons for washables, use delergenl 

and hOI waler. Keep and wash PPE sopar:llely lrom olher laundry, 

When handlers use closed syslems. enclosed cabs. or aircralt in a manner Ihat meolS Ihe requiremenls lisled in Ihe Worker Proleclion 

Standard (WPS) for agricullural peslicides [40 CFR tiO.240 (d) (4-6)j, Ihe handler PPE rcquiremenls may be reduced or modified as 

specitied in rhe WPS. 

ACCEPTED 

i I 1997 

101 
,-----~~-~ ...• ~ --------------

User Safety Recommendations 

Users should wash hands before eallng, drinking, chewing gum, using tobacco or using tho toilel. 

Users should remove clothing Immediately it peslic!de gets Inside. Then wash body thoroughly and put on clean clothing, 

Users should remove PPE immediately aHor handling this producL As soon as possible, wash thoroughly and change inlo clean 

clothing. Wash the outside o~9loves belore removing. 

. ...... ENVIRONMENTAL HAZARDS ........ 

Do not apply direcUy 10 water, or 10 areas whore surface waler is present or 10 intertidal areas below tire intAtn high waier mark. 

conlaminale water when disposing of equipmenl washwalers, .. .. : ••• : .. 

Do noJ contaminate water used lor irrigation or domestic purposes. 

SPRAY DRIFT 

...... .. • • 

•• • •• ..... .. • • 

• 

• • •• 

Donol 

Avoid spray drilL Do not apply when weathor conditions may cause dnff. Do not allow this product ie-drift on to non.ta!£!et areas. DrOt 

may result in illegal residues or injury to adjacent crops and vegetation, in the lorm 01 leal yellowing and detoH~ion~ to avoid spray 

drift, 00 NOT apply aerially when wind speed ts groater than 10 mph or during period!> of temperature inversions. OMbt larger droplet 

size will also reduce spray drift, ..... : 

AVOIDING SPRAY DRIFT AT THE APPUCATION SITE IS THE RESPONSIBILITY OF THE APPLICATOR. •• 

The interacllon 01 many equipment-and·weather·relaled laclors delermine the potenliat lor spmy drift. The appHcator is responsible tor 

•

conSidering all these factors when making decisions, 

The tollowing drilt management requirements must be tollowed to avoid oll·target movement from aeriat appijca![ons to agricultural tield 

crops. These requirements do not appty to lorestry applications, public heaUh uses or to applications using dry formulations. 

1 The distance ot the outer most nozzles on Ihe boom must not exceed 314 Ihe length oJ the wingspan or rotor. 

2, Nozzles must always point backward parnUel with the air stream and never be pointed downwards mora than 45 degrees. 

Where stales have more slringent regulations, they should be observed. 

The applicator should be lamltiar with and take into account the intormation covered in the Aerial Dr'dt Reduction Advisory below: 

AERIAL DRIFT REDUCTION ADVISORY 

[This section is advisory in nature and does not supersede the mandatory label requirementsj. 

INFORMATION ON DROPLET StZE 

The most eUeclive way to reduce drill pOlential is 10 apply targe droplets. The besl drift management strategy is to appty tho largest 

droplets Ihat provide sutlicient coverage and control. Applying larger droplets reduces drill potential, bul will not prevent drill II 

appilcalfons are made improperly. or under unfavorable environmental cond[lfons (See Wind, Temperature and Humidity. and 

Temporature Inversions). 

CONTROLLING DROPLET StZE 

•

volume - Use high How rate nozztes to apply the highest practical spray volume. Nozzles with higher raled Bows produce larger 

roplets, 

Pressure· Do not exceed tho nozzle manulacturer's recommended pressures. For many nozzle types lower pressure produces larger 

droplets. When higher 1I0w rates are needed, use higher How rate nozzles instead 01 increasing pressure. 

Number ot nozztes - Usc the minimum number 01 nozztoo that provide unilorm covera~. 

Nozzle Orientation· Orienting nozzles so Ihat the spray is released parallel to the airstream produces larger droplets than olher 

orientations and is the recommended practice. Significant deflection from horizontal wilt reduce droplet size and increase drift 

potential. 

Nozzle Type· Usa a nozzle type that is designed tor the intended applicaHon. With most nozzle types. murower spray angtos produce 

tafger droplets. ConSIder using low·drill nozzles. Solid stream nozzles oriented straighl back produce the largest droplcts and the 

lowest drill. 

800M LENGTH 

For some use pauerns. reducing the eJtective boom lenglh 10 less Ihan 3f4 ot tho wingspan or rotor length may turther reduce drill 

without reducing swath widlh. 

APPLICATION HEIGHT 

Applications should not be made at a height grealer Ihan to teet abovo the top of the targot plants unless a greater height is required 

for aircralJ salety. Making applications at th.e lowest height Ihal is sate reduces exposure 01 droplets to evaporalion ard,wind. 

SWATH ADJUSTMENT 

When applicalions arc made with a crosswind, the swath will be displaced downwind. Therelore, on the up and downwind edges 01 tho 

Held, the applicator should compensate lor this displacement by adjusting the path 01 the aircraft upwind. Swath adjustment distance 

should Increase. with increasing dritt polenlial (higher wind. smaller drops, etc.). 

102 
WINO 

Drill potentia! is lowesl between wind speedS ot 2 - to mph< However. many faclors, including droplet size and equipment type 

determine drirt potential at any given speed. Application should be avoided below 2 mph due to variable wind direction and high 

Invor$ion potential. NOTE: Local terrain can influence wind patlern$. Every applicator should be ramiliar with local wind patterns and 

how they aUect spray drill. 

TEMPERATURE AND HUMIDITY 

When making applications in low relative humidity, set up oqUipmenl to produce larger droplets to compensate lor ev~poration. Droplet 

evaporatton is most severe when conditions are both hot and dry. • ••• •••• 

TEMPERATURE INVERSIONS •••••• • • •• Applications should not occur during a temperalure inversion because drift potential is high. Ternpemlure ill.versioos I'Ktrlct vertical air 

mixing, which cau&es smail suspended droplels to remain in a concentraled cloud. This cloud can mt". to.!ilnpre~,a~ ·directions due 

to the light variable winds common during inversions. Temperalure inversions are characterized bY.illcreasing. Lem",eratures with 

allitud& and are common on nights wilh limited cloud cover and light to no wind. They begin 10 lorm NioJ/'/, sun sets and:bllen continue 

into the morning. Their presence can bo indicaled by ground log; however, if log is not presenl, invewOQ\~an alsO ~identi!jed by the 

movement 01 smoke Irom a ground $Curce or an aircraft smoke generator. Smoke that layers and moves later'lUy 11".a concentrated 

cloud (under tow wind conditions) indicates an inversion, while smoke that moves upward and rapidly dissIpates i"'ii!'!,t1"l good vertical 

alr mixing. 

SENSITIVE AREAS 

• •• • 

•• 

•• 

The pesticide shOUld only be applied when the potential tor drill to adiacenl sensitive areas (e.g. reSidential areas. bodies 01 water, 

known habitat lor threatened or endangered species. non·tergot crops) is mInimal (e.g. when Wind is blowing away trom the senslilve 

_areas). 

USE PRECAUTIONS 

Do not apply PREP'" bland Elhephon tor Colton and Tobacco Ihrough any type 01 irrigation syslem. 

Avoid :>pray driltto nearby crops 85 this product win cause modifications In planl growth. Plant injury or reduced yields wlU result 

Mix only the amount 01 spray you expect 10 use each day, Do not allow mixed solution to stand overnight. 

DIRECTIONS FOR USE 

It Is a violation 01 Federal law to use this product in a manner Inconsistent with its labeling. 

00 not apply thrs product rn a way that wI!! contact workers or other persons, erther directly or throu9h drift. 

Only protected handlera may be In the area during application. For any requrrements specific to your State 

or Tribe, consult the agency responsible for pesticide regulaHons. 

Read entire tabel before using this product. 

Use this producl only in accordance with ilS labeling and with Ihe Worker Protedion Standard, 40 CFR part t70. This standard contains 

tor the protection 01 agricultural workers on farms. lorasts. nurseries. and greenhouses, and handlors 01 agricultural 

. i It contains reqUirements tor training, decontamination, noUilcat!on, and emergency assistance. It also conlains spocillc 

and except10ns pertain'lng 10 the statements on this label about peJsona:1 proteclive equipment (PPE), notilication 

workers and rastricied-enllY intervals. The reqUirements In this box only apply to uses otthls product that ar~ covered by ihe W,,,k.,.! 

Protection Standard. 

00 not enter or allow worker .ontry inlo treated areas during ihe reslricted-entry interval (REI) 01 4B hours. The REI is 72 hours in 

where average raintall is less than 25 inches per year. 

PPE required tor early entry 10 treated areas Ihat is permitted under the Workor Prolection Stand;ud and that involves contact it 

anything that has been treated such as plants, soil or water is coveralts over long-sleeved shirt and long pan IS, chomical resistanl 

gloves such as any waterproof.gloves, chemical resistanl loolwear Plus socks. and protective eyewear. For overhead exposure, 

chemical-resislanl headgear is also required. 

103 
""----

STORAGE 

Do not contaminate water, food, or feed by siorage or disposal. 

If container is broken or conlents have spilled, follow aU precautions indicatod above and clean up Immediately. Before cleaning up, 

put on full length trousers, long sleeved shirt, pro/ectlve gloves, and goggles or face shiefd. Soak up spill with absorbent media such 

as sand, oarlh or other suitable material and dispose of waste al an approved waste disposal facility. :.-. 

PESTICIDE DISPOSAL •••• 

Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture, or ri~;~.ru·i a vjo.Laljo~.of Federal law, 

If these wastes cannot be disposed of by use according to label instructions, conlact your Slate P.oPJi¥IPP or EOfifMmenlal Conlrol 

Agency or Ihe Hazardous Waste repro.sentalive at Ihe nearest EPA Regional Office lor guidance. • ••• •••• 

CONTAINER DtSPOSAL ••••• ..! 

Tripfe rinse (or equivatent) Ihe empty containers. Then offer for recycling or reconditioning, or pUf"lCll,tU-eoand dispose of in a sanitalY 

landllll, or by Incineration or if allowed by state and local authorities, by burning. If container is burned, stay out ol.smlW:t. 

RETURNABLE - REFILLABLE CONTAINERS •• ! ..• 

After use, return the container to the point 01 purchase or designated locations. This container must only be relillet!:\ti1h fREPw brand 

ElhephOn for Cotton and Tobacco. DO NOT REUSE THE CONTAINER FOR ANY OTHER PURPOSE. Prior to Milling, inspect 

for damage such as cracks, punctures, abrasions and damaged or worn out threads on closure dovices. Do not reliU or 

leaking containers. Check lor leaks after retilling and before transportation. If the container is not being refilled, 

GENERAL INFORMATION 

COTTON 

A foliar spray 01 PREpnl brand Elhephon lor Cotton and Tobacco will accelerate opening of mature unopened cotton bolls and enhanco 

defoliation which can result in eartier harvest with an increased recoverabfe yield. PREP'''' treatment on collon allows increased 

elflciency Irom a once·over harvest. 

TOBACCO (FLUE-CURED): A loHar spray 01 PREpN brand Ethephon promotes early, uniform 'yellowing' 01 mature tobacco. 

PREpw roouces curing time, allowing more efficient use of curing barn space, and increased control oYer harvest schedules. 

SPRAY PREPARATION 

Add 112 to 314 of the required amount of water to the spray tank. Start agitation. Add tho required amount 01 PREp!"" brand Ethephon, 

and tho remaining amount of water. Prepare only as much spray solution as can be used on tho day 01 mixing. Do not allow spray 

solution lostand overnight. Do not spill the concentrated product on spray equipment. or any airplane parts. 

ANY SPIllS SHOULD BE RINSED IMMEDIATELY WITH PLENTY OF WATER 

Use 01 a nurse tank is highly recommended lor aVOiding possibte spills of concenlrated formulation on spray equipmenl or any airplane 

parts . 

.rANK MfXTURES WITH DEFOLIANTS AND INSECTICIDES 

~REPw brand Ethephon is compatible with DEF1, FOLEX®, Dropp", Harvade3. Methyl Parathion, Gulhion I, and Mrualhion4 .. PREP'" 

may be applied in sequence or as a tank mIxture (DO NOT TANK MIX WfTH DESICCANTS IF COnON IS TO BE SPINDLE 

HARVESTED). FoUow all applicable use precautions and rale per acre recommendations on labels 01 producls applied as tank mixtures 

or in .sequence with PREP '1M bcand Ethephon. In some cases slight reduchon in boll opening response has been observed when tank 

mixes wilh deloliants were used. 

Good agitation in the spray tank fs essentiat and a tank mixture should not be allowed to stand without agltati"on lor more than 5 10 to 

minules. Read and observe all appropriate label usc directions and pr~cautions for the defoliants and insecticidos used. 

NOTE: UNDER CERTAIN CONDITIONS, TANK MIXTURES OF PREp:" BRAND ETHEPHON WITH DESICCANTS CONTAINING 

SODIUM CHLORATE COULD RESULT IN THE FORMATION OF HYPOCHLOROUS ACIDS WHICH ON HEATING WILL EMtT TOXIC 

CHLORIDE FUMES. 

DO NOT MIX PREpr" BRAND ETHEPHON WITH AMMONIUM THIOSULFATE. SUCH TANK MIXTURES MAY RESULT IN FORMAT!ON 

OF TOXIC FUMES. 

EQUIPMENT CLEANING 

Because 01 the acidic nature of thiS produCI. prolonged exposure to spray deposit will damage acrytic plaslics. certain paints, and 

metals. 

Rin.so thoroughly with a delergent and water all exposed aClYlic plastic-type materials (e.g., aircraft windshields). and painled surfaces 

within an hour after exposure to spray deposits. 

At the end of each day, rinse thoroughly with a detergent and waler all the metat parts 01 the afrcraft and the associated spray 

equipment exposed 10 the spray deposits. 

104 
COTTON 

USE EXPECTED PREpw ,~ !;, SPRAY APPLICATION 

CONDITIONS RATE VOLUMES TIMING 

(Gals/A) 

pi .f. Ilas A,1. Acr •• Air'" : ... PREP'" HoI and dry 80"F or 1 113 1.0 6 .I.pply when-the numbor 01 

Boll Opener' higher , ,/.lnopenad bolls is 

Dry and 75 to 8O"F 2 1.5 4 i '6- Ihe 

15 - 50 2,5 i ldOf~~!i;~ee below lor 

Cool but above 6soF 2213 2.0 3 •• ~st maturily, 

I opens 

01 •• ,olls ,,~ I 

I 

PREP'" + High soil moisture 113 0.25 2. 15 - 50 5· to 

FOLEX:>: Apply 4 ~:~~!r;:tnor to 01 PREPH~ opening 

Defoliant Tank High lertilily level application. bo used as 

Mix" 01 a se1~~~:lllrealment with, not in of PREP'''' boll I Asok collon I 

rnO' Oropp High soil moisture 113 0.25 2. to-50 3 - 10 Apply 4 to 7 days prior to 

Defoliant Tank High tertitily lavel PREP'''' boll op~ning 

Mix" Rank cotton application. To be used as 

a se~~~~:llrealment with, nol in I of PREP:" boll 

Pre-Conditioner Hot, dry, above 80~F 213 0.5 12 Apply 4 10 7 days prior to 

to, Defoliation Cool. abOve 65'F 1 113 1.0 6 t5- 50 2·5 defoliant. Enhances top 

01 crop deloliation reducing 

deterioration 01 bottom crop 

Rank cotton .nd allows 101 earlier 

Pretreatment With Defoliants Prior to PREpnt brand Ethephon Boll Opening Treatment: II Ihe cOllon 

is overly rank or laying down in the middies and good spray coverage 01 tho boUs with PREP'''' is diUicull, a pretrealment with 

delo~ants will be uselulto improve boll coverage with PREP"" < Use dosage rates 01 PREP"" recommonded for boll opening, Read 

and observe all appropriate label use directions and precautions lor Ihe delolianl used . 

•• Can use up to lull label rate lor each product. e·· In Catilomia and Ariz:ona use a volume 01 no less than 5 gallons per ~cre lor aerial applicalions. 

Boll Maturity 

A boll is mature when il is too hard to be dented when squeeled between thumb and fingers. 100 hard 10 be sliced with a sharp knile, and 

when the seed coal bccomoslighl brown in cotor. 

Use Limitations 

• Do not excoed a maxrmum ot 2.0 lb. othopllon active ingredient por acre per year through combined or repeated uses ot ally 

ethephon products, 

Boll Opening: Do not tank mix PREP I'" brand Ethephon with a desiceant if the collon is to be spindle 11arvestad. 

• Pre-Condilion tor Detoliation: 00 not tank mix PREP»" brand Ethephon with dosiccants untess ptant desiccalion is requirod. 00 not 

use a deloliant bolore thore is sutftcient mature unopened bolls to produce rhe desired yietd {see General tntormation section on 

how to test for boll maturity. 

• DO NOT APPLY PREP"'" BRAND ETHEPHON IF RAtN IS EXPECTED WITHIN 6 HOURS. Raintat! within 6 hours 01 application may 

reduce product perlormance. 

00 not ptant another crop within 30 days alter treatment. 

WHEN TO HARVEST COTTON 

00 not harvest cotton sooner than 7 days alter a treatment with PREpm brand Ethephon. 

Observe the treated crop and harvest when optimum boll opening has boen rcached. Too earty halVest might reduce the tull advantage 

01 the treatment and too late a halVest may reSUlt in reduced quality and loss 01 lint which will drop trom the plant 

105 
PREP'''' 

Crop Situatfon Ptnts/Acre 

Directed Spray 

Application 

Over.The-Top 

Applicalion 

11/3 

t 1/3-22/3 

USE LIMITATIONS 

50-60 

40-60 

TOBACCO 

(Flue-Cured 

Specfffc Directions 

Use drop nonles. Choose TG or OC spray fips 

gpa at 35-40 psi and at tractor speed 

2 nozzles per row; one on each side of 

the spray fo the leaves to be ripened 

om,.,,!!eiS essentiaL With a directed ,p!,~y,.~,!"". I 

only when leaves remaining on To ensure 

remaining leaves are mature, test plants as 

described under tho section "Proper I tho lower rate 

in a normally mature crop when experience lndicafes tl$t p1!"iq!um ripening 

inducement is required, Use the higher rate when fhe Crd!t"i!;'heavy and has 

a tendency to be more rank or when temperatures an1frao.otePIhan normal. 

Always test spray to determine if the tobacco is mature enoll;h to ,.,po,," I 

10 trealment with PAEPlM 

Apply over.the.top PAEP"'" spray as a tine mist using three nozzles (one 

nozzte lips over the centor of tho plant. and one on each side) so atlleaves 

are covered thoroughly, similar to the pallem ot systemic sucker 

" 

• Do not apply PREP'" brand Ethephon to immature leaves as this can result in unsatistactory coloring, weight loss and reduced leat 

quality. 

• Do not allow the crop to over ripen in the Hold after uSing PAEPN brand Efhephon, since this may cause some reduction in yield and 

quality. 

• Do not Ireat before anticipated maior storm which coutd prevent harvest and resufl in crop loss. 

• DO NOT APPLY PREPl" BRAND ETHEPHON IF RAtN IS EXPECTED WITHIN 6 HOUAS. Aainlall within 6 hours 01 application may 

roduce product perlormance. 

Do not use PAEP"" brand Efhephon with additives other than recommended on this label. 

Do not plant another crop within 30 days after treatment 

• Do nol exceed a maximum of 2.0 Ib othephon active ingredient per acre pcr year through combined or repeated uses ot any 

ethephon products, 

APPLICATION TIMING 

Successtul results with PAEP'''' brand Ethephon call for treatmont when leaves aro mature, not overly rank green when sprayed. To 

easily detennine the proper treatment timing and the number 01 leaves per stalk ready tor harvest. test spray several plants in more 

•

than one tocation in each field and observ,e tho response. Mafure teaves will begin to yelklw in 24 to 72 hours. Test leaves that fail fo 

yoUowJn 72 hours are not mature and arc not ready for PAEP"" treatment. Wait a few days to permit further natural maturing, then 

make another test spray or "mafurity" check, 

To avoid quality foss and or possible leal drop, harvest any yen owed teaves prior to application. Use tower rates under most conditions. 

LImit use of higher ratoe 10 cool (below 65F at tho time ottroatment) slow ripening conditions. 

When you have conUrmed 1he desired number ot leaves per plant that will cotor, yoU can determine the number ot ncros to treat in ardor 

to fill the bam. 

Prepare your test spray by mixing one teaspoon of PAEP'" brand Etl'lOphon in 1 quart 01 water. Spray each test plant with about t oz. 

of this mixture, covoring all leaves with n fine mist. PREP'" will not color immature sprayed leave$. 

WHEN TO HARVEST 

AU mature, sprayed leaves will begin to cotor within 24 to 72 hours allor PREP'" brand Elhephon applicatiOn. The yellowing process is 

weather dependent; cool weather will delay, while hot, sunny woather can speed up the process. Harvest treated tobacco when leaves 

have roached the desired color intensity. . 

Harvest can commence 48 hours after PREpl', brand Ethephon app6cation. To determine harvest timing and avoid quality 1055 or leal 

drop, Closely monitor treated crop and weather conditions-. 

CURING PREpn< BRAND ETHEPHON TREATED TOBACCO 

Curing procedures are as much an art as a scionco and each cure must be fudged on the basis of tobacco condition, interval between 

trealment and harvest, weather and Iype of curing tacility befote: proscription temperature and ventilation schedules can be 

established. To obtain maximum quality, care must be taken to observo and control the curing process closely. especially during the 

late ·coloring' and early ~drying· stages of the leaf. 

PREP'" brand Ethephon Ireated tobacco will have started the colOring process when harvested, reducing the time required in the 

coloring phase of CUring. Treated tobacco should be dried faster. If lobacco loaves are green or contain some groon when harvested, 

it may be necessary to color them tor a fow hours. It tho leaves are completely yellow, temperature and venflJation must be adjusted in 

a manner to dry the tobacco as fast as pos.sible without scalding. Once the leaf Is dried (3/4 dry), you should follow normal procedures 

tor curing. Since pAEp!" treated leaves cure faster, treated and unlreated leaves should not be cured fogolherjn the same bam. 

106 
LIMITED WARRANTY AND DISCLAIMER 

The manufacturer warrants (s) thai this product conforms to tho chemical description on the label; (b) Ihallhls product is reasonably fil 

lor the purposes sel forth in the directions for use when II Is used In accordanco with such diroclions; and (c) Ihal tho directions, 

warning and other statements on this label are based upon responsible experts' evaluation of reasonable tests of effectiveness, of 

toxicity to laboratory animals and to plants, and or residues on food crops and upon reports 01 field experience. Tests have not beon 

made on all varieties orin all slates or under aU conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS ALLIMPUED WARRANTIES OF MERCHANT·ABILITY OR FITNESS FC\A",pARTlCULAR 

PURPOSE. •• :. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIB~!.pofiill. ANY ANO ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS I~COf.J~ISTENT W~H THE LABEL 

DIRECTIONS, WARNINGS OR CAUTIONS. •• •••• : ••••• • • 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY !telR AN'f"'iO:,4LL CLAIMS, 

LOSSES. DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDliNG OFTHIS PRODUt;If:WI;IETHER OReHOT BASED IN 

CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR OTHERWISE SHALL BE LIMITED, AT lH&IAANUFACTWRER'S OPTION, 

TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE PRICE FOR, THE QUANTITY OF PRODUC'; WIn! RE$PECTTO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHAll MANUFACTURER OR SELLER BE LIABLE FOR sp~ru\o TNOIRECT OR 

CONSEOUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. ••• • 

•• NOTfCE TO BUYER •• 

Purchase of this produci does not confer any rights under patenls governing this product or the use thereof in countries oulside otthe 

United States . 

• 

• 

IDEF and Guthion are regislered trademarks 01 Bayer AG, Germany. 

2Dropp IS a registored trademark of AgrEvo. 

)HaIVadG is a registered trademark 01 Uniroyal Company . 

. 1Malathion is a trademark ot American Cyanamid Company. 

Rh6ne-Poulenc Ag Company 

P.O, Box 12014,2 TW. Alexander Drive 

Research Triangle Park. North Carolina 2n09 

PREP is the trademark of Rh6ne-Poulenc. 

FOLEX is a registered trademark 01 Rhone-Poulenc. 

PREP'" brand Ethephon for Cotton and Tobacco (PENDING) Submilled 11t6/96. Resubmitted 4117197. 

107 
---~~----- ~~------------------

• 

• 

RH6NE·POULENC AG COMPANY 

EPA Correspondence No. GSPfeth/046 

April )7. 1997 

U,S. Environmental Prolcc!ioll Agency 

Office of Pesticide Programs 

Document Processing Desk (H7504C) 

Room 266A, Crystal Mall 2 

1921 Jefferson Davis Highway 

Arlington, V A 22202 

Attn: Ms. Cynthia Giles Parker (PM No. 22), 

•••••• 

• •• 

• • 

•••••• • .. • 

•••• • • • ••••• 

RE: EPA Reg. No:- 2(}4~41& PREpn! brand Elhcllhon for COUOIl and Tubacco; Label 

revisions in response 10 your corre,sponticllce of March 27, 1997. 

Dear Ms. Giles· P:lrker. 

•••• • •••• 

• 

• • 

••••• • 

• 

••• • 

• .. • 

• 

· .. •• • 

•••• 

••• • 

• .. • 

I am submitting five copics of a draft label witlI the com~ttiuns which yOll requested in 

your March 27, 1997 correspondence. I have highlighted the changes on onc of these 

labels [0 facilitate your review. 

The following changes have been made: 

Hazards to Humans Secllon: 

Replaced lext wilh recommencled wording . 

Statement of Practical Treatment Section: 

Changed title to "FIRST AID" 

Deleted "If Inhaled" Slalement 

If on Skin: added: "Getl11edical :llten!ion:' 

If Swallow'ed: Added ·'or Pili son Cumrol Center". 

Note to PhysiCian Section: 

Moved this section from precautionary statements ttl fIRST AID section 

Aclded: ·'Treat sympl(m)~uically. Consideration Sllould be given to the possibility 

that over Cxpos\lrc to materials orher than thi~ producl may have occurred. No 

specific anticlote is available. Probable mucosal damage may contraindicate the use 

of gastric lavage," This Sliuemcnt complies with your input and was recommended 

by our corporate physician ;15 appropriate for all ethcphon labels. 

Deleted: Entire prior statemellt. 

,>() [lOX 1m1". z I',',' ALEXMiO!011 r,HiV~ 

H<'5(ARG;-i IRIMK,tE hlP;;;. H C 2:70" 21l1-1 

(1tO~s--.:J":X1OO 

Exceffence in Performance 

Pride in Achievement '1'1. "JlI4AIIO~g" TtL!:'>: !;Wl.Rrfi .FlS9J7H·MJ~;Wr HEAC( !<r>::: '''Of' 

11HH1N.".Tion:..I_ I)I$m;8U]I(l!-1 srrWICFS 1 (i F'X tl0~\CH.n ::~'-::n:r!7-AH.S','il:f1HhY i·1 <-, li--,;:; 

108 - ~-.~.----------
• 

• 

PPE Section: Modified glove stalement 10 meel current requiremenls. 

Directions for Use section: 

Moved first paragraph from Agricuhnral Use Requirements box to text above box . 

Use Limitations section: Modifed 2.0 Ib ailA statement as suggested. • ••••• 

• •• 

• • 

•••••• • • 

•••• • •••• 

• 

• • ••••• • 

· 

If you have any questions concerning this matter, I ClIli be reached at 919-54§-2687~··. : 

••••• •• 

Sincerely. 

~~ Gail Powell. Ph.D . 

Registration Manager 

.... • • , 

. ·, .. . •••• 

... • .. • 

109 -----------~---.. -
• 

• 

• 

CERTIFIED MAIL 

Gail Powell PhD. 

Rhone-Poulenc Ag Company 

P.O. Box 12014, 2 rw Alexander Drive 

Research Triangle Park, NC 27709 

Dear Dr Powell: 

Subject: Reregistration 

~'7 1997 

PREP brand Ethephon Plant Regulator For Cotton and Tobacco 

EPA Registration No. 264-418 

Your Submissions Dated January 16 and March 13, 1996 

We cannot accept your labeling submitted for reregistration of ethephon until you 

submit five (5) draft labels with the following corrections. 

1, Update the Hazards to Humans section so it reads as follows: 

Corrosive. Causes irreversible eye damage and skin burns. Hannful jf 

swallowed or absorbed through skin, Do not get in eyes on skin or on 

clothing. 

2. In the Statement of Practical Treatment Section you may delete the IF INHALED: 

secllon since this product is in Toxicity Category IV for inhalation toxicity. At the bottom of 

this section add: 

NOTE TO PHYSICIAN' Probable mucosal damage may contraindicate the 

use of gastriC lavage. 

3. In the IF ON SKIN statements add 

Get medical attention. 

4. Delete the Note to Physician section in the Hazards to Humans section. 

110 
I 

1 

.. J ~ 

• 1::4 .. ... 

. ~ 

. .l ., 

• 

• 

-2-

5. Move "Do not apply this product in a way .... agency responsible for pesticide 

regulations" out of the Agricultural Use Requirements section to immediately below the 

heading "It is a violation of Federal.. .. with its labeling." 

6. Modify the Use Limitation so it is clear that the maximum that can be applied to 

cotton is 2.0 lb. of ethephon as active ingredient per acre from all sources of ethephon not 

just this product 

Submit the labeling reflecting the above mention changes to the Agency for review 

within fifteen (15) days of receipt of this letter. Failure to do so will result in issuance of 

a Notice of Intent to Suspend your product's registration. 

cc: Wanda Daughtry 

Judy Loranger 

Reregistration Branch 

Sincerely, 

~. J /-

.... ; , . . . Cynthia Giles-Parker 

Product Manager (22) 

Fungicide-Herbicide Branch 

Registration Division (7505C) 

Special Review and Reregistration Division (7508W) 

113 ._. -- --------------------------
PREpTM brand Ethephon 

FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

.ACTIVE INGREDIENT: Ethephon (2-Chloroelhyl) phosphonk: ac;d' ........................................................ 55.4% 

INERT INGREDIENTS: ..............................•.....•........•............................................................................. 44.6% 

"This product contaIns 6 pounds elhephon per gallon. 

EPA Reg. No. 264·418 EPA Est. No. 264·PA·01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

Si uSled no onliGnda fa Gllqueta, busquo a algulon para quo $0 la oxpUquo a ustod on detallo. 

(It you do not undQrstand the label, find somoone 10 oll:pfain it to you in dotaiL) 

• -"Fiiorr iMiiE[i02jlltC;1AiiL;:1A"niddl:r[RBAA]N[iS[jP~D:l:Bii:TIAAjT'iilol2ilN:EEnmii.;;-rgiji.;;ni(c;j:I .... i1Oi.iN~Li:Y~CSCiiiliiI12i44-HHGOuiir;;.iAAr:DO';.y~lN.8BiDf).x;::33:3j;4-i=7715517'77;-­

For PRODUCT 1l.S.E. Information Call 1~800~334-9745 

Tho use of thIs product for a varioty of plant growth regulation usas aro protected by United Stalos and foreign patenls including 

U.S. Palent 4,240,819. No ricon$(J is granted to use this product In counlr!es olho( than the United Stales or for any use not 

contemplat&d by this laboL liability for patent Infringement may result from use or sale of this product outside the United States.~ 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyelids opon and flush with a gentle stroam 01 wat~r for at least 15 mInutes. Get medical attention, preferably an 

ophthalmologist. 

IF ON SKIN: Immediately wash skin with plenty of soap and water. (')-e \y , I 

IF SWAUOWED: Do not induce vomiting. Promptly drink a large quantity of milk. egg whiles, gelatin solUlion or if these are not 

available, drink large quantitios of water. Avoid alcohol. Call a physician imm&diatoly. 

IF INHALED: Remove victim to fresh air. If not breathing, giva artificial respfradon. Administer oxygen if n&CGsssry. Get medical 

atlention. 

PRECAUTIONARY STATEMENTS 

• DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. Causes IIyG and skin damag&. ~ be fatal if absorbed through skin. Harmful if swallowed or inhalod. Avoid breathing 

spray mist 00 not get in eyos, on skin or on clothing. Koep away from domestic animals. 

Nore TO PHYSICfAN 

There is no specific antidote. All trealment shook! be based on observod signs and symptoms of distress in tho patient. Overexposure 

to malorlals other than this prod~ .baw:,,~ned, 

Victims of sever. overexposure'~o1nhal8fioJ't..,~ould be kept undor modical observation for up to 72 hours for delayed onset 01 

~ pulmonary edema. In s victim of 'tNGr~·G~poslfflj by ingestion, carelul 9islrk: lavage is required dUG to tho possibiffty 01 stomach or 

~ 

osophagoat pMioration. this matenal Is an acid, but use of alkaline subsTances to neutralize it is contraindicated, ... • • •••• PERSONAL PROTECTIVE EQUIPMENT (PPE) • • 

Applicators and othor handlers must wear coveralls: ovor sllort-skloved shirts and short pants, waterproof glotal"~omicaf.rQsistant 

lootwear plus socks, protoctivG oy.wear, chomical·resistant headgoar for ovorhead exposuro 1ll~.c;Qemical.re~stant apron when 

cleaning equipment or mbdng and bading. : .: ••• 

Discard Clothing and' othor absorbent materials that have been dronched or heavily contamlnatedv41;.Ibis proZlul:t.s.&lncentrato. 00 

not reuse thom. Fotiow manulacluror's instructions for cleaning/maintaining PPE. If no such instrt.Jctl:V'\:fior wasbablo" usa dotergont 

and hot water. KOGP and wash PPE separaloly lrom other laundry. ••••• • •••• : 

When handlSfs use closed systems, enclosed cabs, or aircraft in a mannor that moets Iho requirelll861,a.I!'Sled in th90Workor Protection 

Siandard (WPS) for agricultural pesticides [40 CFR 170.240 (d) (4-S)), the handlor PPE requirements may be: ~U&Jd or modified as 

spoo!ied in tho WPS. • .: ••• 

.... · .. •• • 

114 
• 

User Safely Recommendallons 

Users shoUld wash hands OOloro ealing. drinking. chawfng gum, using tobacco or using the toRot. 

Users should remove clothing immodiately if pesticide gets insido. Thon wash body thoroughly and put on clean clothing. 

Users should remove PPE immodiatofy after handflng this product. As $000 as. possible, wash thoroughly and chang. Into cloan 

clothing. Wash tho outside of glova, befor. removing. 

ENVIRONMENTAL HAZARDS 

00 not apply dirodly to water, Of'to areas whore surface water is prosent or to Intortldal aroas below tho moan high wat~r mark., Do not 

contaminate wator when disposing of equipment washwaters. 

00 not contaminalo wafer used lor Irrigation or domostic purposos. 

SPRAY DRIFT 

Avoid spray drift. 00 nol apply whon woathor conditions may cause drih. 00 not allow this product to drift on 10 non-Iargot areo. Drift 

may result In illegal residuas or Injury to adjacent crops and vogotalion, in tho form of loaf yellowing and detoHation. To avoid spray 

drift. DO NOT apply aerialty when wind speed is greater than fO mph or during periods 01 temperatura Inversions. Use 01 larger droplel 

size win aJso reduce spray drift. 

AVOIDING SPRAY DRIFT ATniE APPUCATIQN SITE IS THE RESPQNSIBIUTY OFTIiE APPLICATOR 

Tho interaction of many equlpment·and-woalher-rel8ted lactors determine tha potential for spray drift. Tha applicator is rosponsiblo lor 

considoring all theso lactors when making docislons. 

Tho following drift managoment roquiremonts must be followed to avoid olf·target movomentlrom aerial applications to agriculturallield 

crops. Those requirements do not apply to lorestry applications, public health uses or to applications using dry lormulations. 

1. The distance 01 the outor mosl nozzles on tho boom must not oxcoed 314 the looQth 01 the wingspan or rotor. 

2. Nozzlas must always point backward paralJoI with the air stream and navor be pointod downwards more than 45 <.!ogrees. 

Where slates have more stringent regulations, they should be observed. 

Tha applicator should bo lamUmr with and take into tiC(:OOnt the Information covered in the Aerial Drift Roduction Advisory below: 

AERIAL DRIFT REDUCTION ADVISORY 

{This section Is advisory in nature and does not supers&de the mandatory label requirements}. 

INFOAMA nON ON DROPLET SIZE 

The mosl affective way to reduco drift potential is 10 apply !arge droplets. The best drift management stratogy is 10 apply Ihe largest 

droplets that provide sufficlont coverage and controL Applying larger droplets roduces drift potential, but will not prevent drift n 

applications aro modo improperly. or under unlavorable environmentai conditions (Sea Wind, Temperature and Humid~y. and 

Temperature Invorsions). 

CONTROLUNG DROPLET SIZE 

Volume· Use high tlow rato nonlos to apply the highost practical spray volumo. Nozzles with higher rated llows produce larger 

droplets. . e Pressure· Do not excooo the noule manulacturer's rocommondod preSsures. For many nozzle typos Iowor pressuro producos largor 

dropklts, When higher llow ratos are neoded. use higher llow rate nozzJos instead of increasing pressure. 

Number 01 nozzles - Use the minimum numbor of nozzlas that provide uniform roverage. 

Nozzle Orientation· Orlentlng nozzles so that the spray is relaased parallel to the airstroam producas larger drop/ets than olher 

orientations and is the rocommendod practico. Signilicant dellection lrom horizontal wili reduce droplet size and increase drift 

potential. 

Nozzle Typo· Usa a nozzle typo thaI is designod lor the inlended application. With most nozzle typos, narrower spray anglos produco 

larger droplets. Consider using low·(hift nozzles. Solid stream nozzles orientod straight back produca tho largesl droplets and the 

Iowost drift. 

BOOM LENGTH •••• • • 

For some usa patterns, reducing the effective boom length to loss than 3/4 01 the wingspan or rotor length 'lIarl~rther reducs drifl 

without reducing swath wklth. • ••••• 

• 

APPLICATION HEIGHT •••••• • 

Applications should not be made at a height greater than to leet above the lOp 01 the target plan. unloH a grtllterth.eight is requirod 

for ai{C1'attswety. Making applications at Ihe lowest heightlhal is sa!e reduces exposure 01 dropl9t.~~aporaUonoand wind. 

SWATH ADJUSTMENT •• • •• : ... ,.. . ... When applicalioos are made wUh a crosswind, Ihe swath wlH bo displaced downwind. Therelore, on me up and dowJlwind odges of Ihe 

llokl, the applicator should compensate for this displacement by adjusting the path 01 the aircraft upwind. Swalh aO!uslment distance 

should incroasa, with Increasing drift potential (highor wind, smallor drops, Gte.). : ••• 

•••• 

.... 

• .. •• . 

115 
po"""'i!',1 is lowest betwoon wind spoeds of 2 • 10 mph. However. man), lactors, including droplot sizo and equipment typo 

dotormine drift potentia! at any giyon spood. Application should bo avoklod be-low 2 mph duo to variable wind direction and high 

inversion potentlal NOTE: Local I.train can influooco wind patterns. Evory appticator should be familiar with local wind panarna. and 

how they aHOd spray drift 

TEMPERATURE AND HUMIDITY 

Whon making applications In low telativo humidity, sot up oqufpmont to produce largot droplets to compensato for evaporation. Droplet 

ovaporation 1$ most SOvoro when condhions are both hot and dry. 

TEMPERATURE INVERSIONS 

Applications should not occur during a !ompet8ture inversion bocauso drift potentia! is high. Tomperaturo invorsions restrict vertical ail 

m1xlng. which causes small suspended droplots to romain in a oonconlrated cloud. This cloud can movo in unpredictable direclions due 

10 tho light variable winds common during inversions. Temperature invorsions arOo characterized by Incruasing temperatures with 

attitude and are common on night$. with limited cloud cover and light to no wind. They begin to form as the SUn sots and oflsn conllnuo 

into the morning. Tholr presonce can be Indicated by ground fog; however, if fog is nol prosent, inversions can also be idenlified by tho 

movement of smoke from a ground source Of an aircraft smoke genarator. Smoke that layers and ITlOV$S laterally In a concentrated 

cloud (undor low wind cond~ions) Indicatos an inversion, while smoko that mov~s upward and rapidly dissipates indicates good verticat 

air mixing. 

SENSITIVE AREAS 

The pesticide should only be applied when thlt potontial for drift to adjacent sensitive areas (e.g. residential arltas, bodies of wator, 

known habital for threatened or endangorod species, non-target crops) is minimal (o.g. when wind is blowing away lrom the sensitivo 

areas). 

e USE PRECAUTIONS 

Do not apply PREpn.t brand Ethophon lor Cotton and Tobacco through any typo of Irrigation system. 

Avoid spray drift to nearby crops ll$this product will causo modifications in plant growth. Plant injury or roduood yiGlds will rosult. 

Mix only the amount of spray you expect to uso Oooch day. 00 not allow mixod SQ!Lrtlon to stand ovornlght. 

DIRECTIONS FOR USE ~. It -i..- a violation of Foderal law to us. this product In a mann.r Inconslstont with 

/ ~ Read entlr. latwll before using this product. 

Its tab.llng. 

, =--------, 

00 not appty this producttn a way that will contact workors or othor porsons, either directly or Ihrough drift. Only prot"oct:"~:':~;'~I~,~: I 

be In tho area during application. For any requlremonts specitlc to your Stato or Trlbe, consutt thlt agency tE I p'''-tlddo rogulations. 

only rn accordance with its taooting and with thlt Worker P~O~'~ect~]io~n~St~at:n~d~'~'d~'~4~O~C~F~R~P'~rt~' 7~:O:;'~j~~2~~si~ I for the protection of agricultural workers on farms, forosts, nursories, and and 

It contain! roquiraments for training. d&eantamlnatian, nQtilicaiion. and 

and exceptions pqrtaining to the ,statements on this label ~about i 

roatricted-Gntry intervals. The requirements In this box only uses product 

Standard. 

not onter or allow workor entry Into troated arens dutlng the rostricted-entry interval JREI) 01 48 hours. Tho REI Is 72 hours in areas 

wh.", ""'"'!10 rainfall is less than 25 Inchos por yoar. 

PPE roquirad for early entry to treat&d areas that Is permitted under the Workar Protection Standard and that involves contact with 

anything that has boon troated such as plants. soil or ~ater is coveralls over Iong-sloeved shirt and long pants, chomical resistant 

gloves such as any waterproof gloves, chomical fOsistant footwear plus socks, and protGctive ayowoar. For overhead oxposuro. 

chemlcal..fO$istant hoadgear Is also required. 

r 

•••••• 

• •• 

• • 

••••• • • • 

• •••• 

..... 

• • . • 

.. . ., . · .. •• •• 

•••• • • • •••• • 

· ., •• • • 

• 

· .. .' . ••• • 

•••• 

• •• .. . 

116 
• 

. , 

STORAGE AND DISPOSAL 

STORAGE 

Do not contamlnato waler, food, or foed by storaoe or dJsposal. 

If container is broken or contants have spilled. follow all precautions Indicated above and clean up immedIately. Sofa!. cloaning up. 

put on full length trousers, long sleaved shIrt, protodivo gloves. and gogglo$ Of face shield. Soak up spill with absorbent media such 

as sand, Garth or other sukablo male rial and dlsposo of was10 at an approved waato disposal facility. 

PESTICIDE DISPOSAL 

Pesticide waJlO. ato acutely hazardous. Improper disposal of excess posticide. spray mixture, or rinsato is a violation of Fodoral law. 

n thase wastes cannot be dispo&ed 01 by UaG according to label Instructions, contact your Stat. Po.ticido or Environmental Control 

Agoncy Of tho Hazardous Wast. representatNc at the noarest EPA Regional Ofllco lot guidance. 

CONTAINER DISPOSAL 

Triple rinse (Ot oquivalont) tho empty conta.inors. Thon offer for tqcycling Of foconditioning, or puncture and di&po$O of In a sanitary 

landfl/f, Of by IncIneration or if alklwod by state and local authorities, by burning. II container Is burned, stay out 01 smoke. 

RETURNABLE -- REfiLLABLE CONTAINERS 

Mer UN, return the conlalner to tho point of purchase Or designated locations. This- oontalnor must only be relHled w~h PREpm brand 

Elhephon for Cotton and Tobacco. DO NOT REUSE THE CONTAINER FOA ANY OTHER PURPOSE, Prior to refUlIng. Inspect 

thoroughly fOr damage such as cracks, punctures, abrasions and damaged or worn out threads on closure devices. Do not rolill or 

transport damaged or loaklng containers. Check for leaks atter relilling and boforo transportation. If tho container Is not boiog refilled, 

return it to tho point of purchase . 

GENERAL INFORMATION 

COTTON 

A loliar spfay of PREPN brand Ethophon for Cotton and Tobaooo will accolerate opening 01 mature unopened cotton bolls and enhance 

defoliation which can result in oarlior harvest with an irn;:feasod recoyerable yield. PREpnt treatment on cotton allows Increased 

efficiency from a once-over harvost. 

TOBACCO (FLUE-CURED): A foliar spray of PREP'noI brand Ethephon promotes early, uniform "yellowing· 01 mature tobacCo. 

PREPD' r&duces curing time, allowing mora efficient use of curing barn space, and incr06$od control OYer harvest schedulos(L--/ 

SPRAY PREPARATION 

Add 112 to 314 of the roquirod amount of water to the spray tank.. Start agitation. Add the t&quirod amount of PREPnc brand Ethephon. 

and tho romaining amount of water. Prepare only as much spray solutIon as can txt used on the day of mixing. Do not allow spray 

solution to stand oYernight. 00 not spJlJ the concentrated product on spray equipment, or any airplane parts. 

ANY SPillS SHOULD BE RINSED IMMEDIATELY WITH PLENlY OF WATER. 

Use of a nursa tank is highly recommended for avoiding possible spills 01 concentrated formulation on spray equipment or any airplane 

parts. 

TANK MIXTURES WITH DEFOLIANTS AND INSECTICIDES 

~ PREpnt bmnd Ethophon is compatiblo with DEFI, FOLEX-, DroW, Harvade3, Methyl Parathion, Guthion1, and Malathion4• PREpN 

..., may be applied in s-oquenco or as a tank mixture (DO NOT TANK MIX -WIlli DESICCANTS IF COTTON IS TO BE SPINDLE 

HARVESTED). Follow all applicab1e us. procautiollS and rate per acto recommendations on labels of products applied as tank mixtures 

or In soquanco w~h PREP 1M brand Ethophon. In some cases slight reduction in boH opening respons. has boen observed when tank 

mixes with defoliants wore usod. 

Good agitation in tho sPfay tank Is assential and a tank mixture should not be allowed to stand w~hout agitation for more than 510 10 

minutes. Read and ob$arve all appropriate label use directions and precautions for the defoUants and insecticldos used, 

NOTE: UNDER CERTAIN CONDITIONS, TANK MIXTURES OF PREprw BRAND ETHEPHON WITH DESICCANTS CONTAINING 

SODIUM CHLORATE COULD RESULT IN THE FORMATION OF HYPOCHLOROUS ACIDS WHICH ON HEATING WILL EMIT TOXIC 

CHLORIDE FUMES. 

DO NOT MiX PREP~ BRAND ETHEPHON WITI-I AMMONIUM THIOSULFATE. SUCH TANKMlxruAES MAY ~".IN FORMATON 

OF TOXIC FUMES. • ••• 

EQUIPMENT CLEANING • • 

•••••• 

• Because of the acidic nature of thls product, proionged exposure to spray deposit will damagl\ ~ip plastics, ptrtain paints, and 

motals. : .: ••• 

Rinse thoroughly with a dotergent and water all exposed acrylic plastic· typo materials (e.g., aircratt.w1odchiold~, a.-·painlad surfaces 

wlthln an hour altar oxposure to spray deposits. • •• • •• 

• •• At ttt. and of each day, rinse thoroughly with a detorgont and wator aU the motal pans of tl'lv.fretaft and"ttJo·:tssociatod spray 

equipment exposed to tho spray dopos~s. ••••• • 

• •• 

•• • 

••• • 

•••• 

• • • • 

117 
• 

..... -- - -----------

EXPECTED PREpm ONE SPRAY VOLUME APPLICATION 

USE CONDITIONS RATE GALLON (Gal./A) TIMING 

PREpm 

TREATS 

Plnt.fA LBS A.1. Acres Ground Air·" 

PREpl'N Hot and dry WF or 1113 1.0 6 Apply when tho numbor 01 

Boll Opon.r· hlghor majuro unopened bolls Is 

Dfy and 75 to 8O~F 2 1.5 • 15·50 2·5 

sufficIent to produce tho 

desired crop. 588 bebw lor 

Cool but above SS&F 2213 2.0 3 lost of boll maturity. 

Treatment uniformly opens 

0' boUs 710 14 days oarHor. 

Aank cotton 

PREtm' + High soil moisture 113 0.25 2. 15·50 5·10 Apply 4 to 7 days prior to 

FOLEX" '" PREpnf boll opening 

Dafoll.nt Tank High fertility 161/01 application. To be used as 

MIx·· 0' 

a sGquonliaJlrealmonl wijh. 

not In place 01 PAEf>ni boll 

Rank cotton I ooooio-o ttoalmen!. 

PREpTM+ Dropp High so~ moiS1uro 113 0.25 24 to ·50 3·10 Apply 4 to 7 days prior to 

O.follant Tank High fortmty lovol PREpm boll oponing 

Mix·· Rank cotion application. To be used as 

a soquentialtrea1mont with, 

not in place of PAEpni boll 

oponir:!·~treatmGnt. 

Pr.·Condltloner Hot, dry, abovo 80eF 213 0.5 12 Apply 4 to 7 days prior to 

fo, D.follatlon Cool, above 65"F 1113 1.0 6 t5·5O 2·5 defollan1. Enhancos top 

"' crop defoliation reducing 

deterioration of bottom crop Rank cotton and allows fo, e.rlior 

harves!. 

·Pretreatment With Defoliants Pnor to PREpN brand Ethephon SoU Opening Treatment 

If the cotlon is ovorly rank or laying down in tho mlddlea and good spray coverage 01 tho bons with PREPnI is difficUlt, a pretreatment 

with dofollants wilt be usofulto imptolle bolt covorago with PREPlW, Us. dosago ndes of PREpm recommended lor boll opening. Road 

and observe all appropriato label us& directions and procautions for tho dalolilU'Jt used. 

"Can usa up to fuillabol rato for oach product. 

• ... In California and Arizona: use a volumo 01 no loss than 5 gallons por acto lor aerIal applications. e Bott Maturity 

;/ 

! -"J 

A boll is mature when it is too hard to be domed when squOGzod OOtwoon thumb and fingors. too hard to bo sliced with a sharp- knit., and 

when tha soad coat becomes light brown in color. 

Use Limitations '. , 00 not excoed a maximum 012.0 lb. ai/A forcomblned uSO$,of PREPN brand Ethophon par acre poryoar_ 

Boll Opening: Do not tank mix PREP'M bland Ethephon with a" aos-icC1ii1tit tho cotton is to bo spincile harvested, 

Pro--Col'Idition lor Dololiation: Do not tank mix: PREpN brand Ethephon with desIccants unless plant desiccation is required. Do not 

uso a dololiant bofore thoro is sufficiont mature unoponed bolls to produco tha desired yield (sea Ganorallnlormation soclion on 

how to tost for boll maturity. • ••• 

DO NOT APPLY PRE?N BRAND ETHEPHQN IF RAIN IS EXPECTED WITHIN 6 HOURS, Rainlall within 6 ~ON'df·application may 

roduc. product porlormanco. : ... :. 

Do not plam anOlhorcrop within 30 days aftor troatman!. • •••••• • 

WHEN TO HARVEST COTTON • .: •• • • • Do not hjlMst cotton sooner than 7 days aftor a treatmont with PREpTSI brand EthGphon. ..: •• :... 

Observe tho traatod crop and harvost whon optimum boll opGning has been ranchO<:!. Too oarly harvosflfllght rodJce.th1t full advantage 

of tho trorumont and too lato a harvost may result in rGduced quality and loss of Nnt which will drop f"""1 m" piant. •• •• 

•• ••• • 

· • • .. ... - •••• • .. •• . 

118 
TOBACCO 

(Flue-Cured Only) 

PREpOI 

Crop Situation Plnta/Acr. 

Diroctoci Spray t 113 

Application 

OVor~Th.·Top t tl3-2213 

Application 

Spray 

Vatu me 

Gattonsl 

Acr. 

50·60 

40-60 

Speclftc Directions 

Use drop nozzles. Choose TG or OC spray tips d&slgnod to apply SO • 60 

gpa at 35-40 psi and at tractor speed of 2-3 mph. Use 

2 nozzl&s per row; ooe on each !lido of tho row droppod low enough to direct 

tho spray to tho I.avos to be tiponod and harvested. Thorough spray 

covorage is osaent)a1. WIth a directed spray, be sure to harv05t allle8ves 

with 20% Of I'l'10(8 yellowino. 

Treat only when I.aves remaining on th. stalk are matur.. To ensure 

remaining leaves are matura, test spray soveral tobacco plants as 

doscribod under tho section -Proper Tlmo of Treatment· Use th. lower rata 

in a normally maturo crop whon exporionc. jndicates that minimum ripening 

inducement is roquiroo. Us. the highor rat. when the crop is heavy and has 

a tendency to 00 more rank or whon temperatures are IoWar than normal. 

Always t.&t spray to detormine n the tobacco is mature .nough to respond 

to treatment wkh PREpm 

Apply over-the-top PAEprw spray as a fine mist using throo noules (ono 

nozzlo tips ovor tho contor of tho plont, and one on oach side) so all loaves 

• 

ar~ cov.rod thoroughly, slmifar to the application pattern 01 systemic sucker 

L. __________ -Lc-________ -"L. __________ ~oo~nl~rn~"~ao~"~nl~'~,~U~,~'~.~'~m •• ~v"o~"~'~'~~rn~o~14~O~I~o~6~O~o'.~L"_ ____________ _J 

USE LIMITATIONS 

Do not apply PREp1lI: bfand Ethephon to immature leav.s as thls can rosult in unsatistactory coloring, weight loss and roducod loaf 

quality. 

Do not allow tho crop to over ripon in tho field altor using PREpl'W bfand Ethephon, since this may causo soma r&duC1ion ln yiold and 

quality, 

00 oat treat bolore anticipated major storm which could provent harvest and result in crop loss. 

• DO NOT APPlY PREflTW BRAND ETHEPHON tF RAIN IS EXPECTED WITHIN 6 HOURS. Rainfall wilhm G hours 01 appIlcat!on may 

reduce product porformance. 

00 not use PRfP!W brand Ethophon with additiv9$ other than rocommendod on this labol. 

Do not plant another crop within 30 days after troatment. ,/. 

00 not eXCHd 21bs ethophon PM acre por yoar. 

APPLICATION TIMING 

Successful results with PREPlW brand Ethephon call fot treatment when leave. are maturo, not overly rank green when sprayed. To 

easily detormlne the proper troatmant timing aM the numbor at leavos per stalk ready lor harvest. tost spray several plants in 1TIOf8 

than one location in each ffold and observe the response. Maturo !Gaves wBI begin to yellow In 24 10 72 hours. Testl.avos that tail to 

yellow in 72 hours are not matoro and are IiOt roady for PREpru. treatment. Wait a tow days 10 permit turthor naturol maturing, then 

• 

make anolhartG&t spray or ·maturity" chock. 

To avoid quanly 106$ and or possible Ioat drop, harvest any yellowed 1~a:v8S prior to appHcation. Uselowor ratos under most conditiomt. 

Umit usa of highot ratos to cool (bolow 6SF at the time of treatment) slow ripening condilions. 

When you have: contirmad tho desired numbor at loaves por plant that wHt color, you can determine tho number of acros to treat in ardor 

10 1111 tho bam. 

Prepar~ your test spray by mixing one toaspoon at PREPno: brand Ethophon in 1 quart at water. Spray oach test plant with about 1 Ol. 

at this mixture, covering alileavos with a tlne mist. PREp-m wlll not color immature sprayod leavas. 

WHEN TO HARVEST 

All mature, sprayed leavos will bog!n to color within 24 to 72 hours after PREpm brand Ethophon application. The yellowing process is 

weather dependent; coot weather will dalay, whllo hot, sunny weather can spe&d up tho process. Hruvest traated tobacco when leaves 

have reached the desired color intensity. • ••••• 

Hruv8$t can commonce 4B hours aftor PREPTW brand Ethephon application. To dotermine harvest timing and avcfK'l·qtality loss or leal 

drop. closo/y monitor troatod crop and weathor conditions. :. _.:. 

CURING PREpN BRAND ETHEPHON TREATED TOBACCO • 

Curing procedures are as much an art as a scienco and each curo must be judgod on the basis ofloSac&" conditio';. interval botweon 

treatmom and harvest, weather and type of curing tacility belore prescription temperaturo lind v4ntllatkSJ1..s.dh&dulos can be 

established. To obtain maximum quality, care must be takon to observe and controt tho curing preet4ltlosolf, .s~ally during the 

lat. ·colorlng- and oarly -drying- stagos at the loaf," •• •• • : 

PREpnI brand Ethephon troatod tobacco will have started tho coloring process whon harvast&<f.UMQing tho'Jma·roquirod in tho 

coloring phaso 01 curing. Tr&atod tobacco should be dried tastor. If tobacco loaves are grean or cOftMrf somo gr.o~ whon harvosted, 

if: may bo nooosslll'f to color thom tor a lew hours. II tho leavos aro complotoly yollow. tomperature and vontilat~n ¢t19J be adjusted in 

a mannor to dry tho tobacco as tM! as posslblo without scaJding. Onco tho Ioat is driod (314 dry), you should follo'h"Mrmai proceduros 

for curing. Sine. PREPTlItreatod loaves cure fastor, troated and untroatGd loans should not be cured togethor ill Hwts-tme barn . .. . 

119 
• 

.. LIMITED WARRANTY AND DISCLAIMER 

The manufactuuN' warrants (8) that this product conforms to tho cll&mica.l dDscriptlon on tho labol; (h) that thit product it roaaonably fit 

for tho purpo ... sot forth In tho directions for usa when It Is usod in acoordance with such dlrec::tlon.; and (c) that tho dlr.aions. 

warning and other statemGnts on this !abol are based upon responsible exports' evaluation of reasonable !oslt of effactlVfflO$S, of 

IOxlclty to laboratofy anlmala and to plants, and of retldues on food cropo and upon reports of field experience. Testa have not baon 

made on aft varieties or In al stat •• or under aU conditlooo. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OruER WARRANTIES, EXPRESS OR IMPLIED. AND IT 

EXPRESSLY EXCLUDES AND DISClAIMS ALL IMPLIED WARRANTIES OF MERCHANT·ABILITY OA FITNESS FOA A PAATlCULAA 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO. AND THE BUYER SHALL BE SOLELY AESPONSIBLE FOA. ANY AND ALl LOSS OA 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS, WARNINGS OR CAl1J1ONS. 

BUYERS EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OA HANDLING OF THIS PRODUCT. WHETHER OR NOT BASEO IN 

CONTRACT, NEGLIGENCE. STRICT UABILITY IN TORT OR OTHERWISE SHALl BE LIMITED, AT THE MANUFACTUAEFrS OPTION, 

TO REPlACEMENT OF. OR THE REPAYMENT OF THE PURCHASE PRICE FOR. THE OUANTITY OF PROOUCTWITH RESPECT TO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAl, INDIRECT OR 

CONSEQUENTIAl DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. 

NonCE TO BUYER 

Purchasa of this product do4t: not oonlGr any rights under palonts governing this product or tho us. thoroof in countries outsida of tho 

Unitsd Statoa • 

'OEF and Guthion are regislarad IratI.marks of Bayer AG, Germany. 

2Oropp is II registered trademark of NOR-AM Chomical Company. 

3Harvadeis a reglatarod trademark of Uniroyal Company. 

"Malathion Is a tradomark of American Cyanamid Company. 

Rh6ne-Poul&nc hJ Company 

P.O. Box 12014. 2 T.W. Alexander Drive 

Research Triangle Park, North Carolina 2n09 

PREP Is the trademark of RhOo.--Poulonc. 

FOlEX Is a registered trademark of RMne.floulorn: . 

PREPN brand Ethophonfor Cotton and Tobacco (PENDING) Submitted 1116196. 

...... 

. .. 

. ... • 

· .. .... · 

• • ••• ..... . . . 

.... . ..... • • 

•• • · .. • · .. •••• 

· .' .... .. . ... . · .. 

120 

/ 
------------------- ---

DP BARCODE, 0233645 

CASE, 003396 

SUBMISSION, S499337 

DATA PACKAGE RECORD 

BEAN SHEET 

DATE, 02/21/97 

page 1 of 1 

* * * CASE/SUBMISSION INFORMATION * * * 

CASE TYPE, REGISTRATION ACTION: 674 8 MNTH RESP-PROD SPC DATA 

RANKING 

CHEMICALS, 

o POINTS () 

099801 Ethephon 55.4000\ 

10#, 000264-00418 PREP PLANT REGULATOR FOR COTTON 

COMPANY, 000264 RHONE-POULENC AG cor~pjUn 

PRODUCT MANAGER, 22 CYNTHIA GILES-PARKER 703-305-5540 ROOM, CM2 229 

PM TE!>l~ REVIEWER, ,IANDA RUFFIN DAUGHTRY 703-308-8171 ROOM, CSI lK4 

RECEIVED DATE, 01/23/96 DUE OUT DATE, 07/21/96 

* * * DATA PACKAGE INFORMATION * * * 

DP BARCODE, 233645 EXPEDITE, N DATE SEWf, 02/21/97 DATE RET., ! 

&;HBMICAL: 099801 Ethephon ~p TYPE: 001 Submission Related Data Package 

CSF: Y LABEL: Y 

ASSIGNED TO 

DIV , RD 

BRAN, FHB 

SECT, PMT-22 

REVR , 

CONTR, 

DATE IN DATE OUT 

/ / I 

( ! I 

/ 

/ 

/ 

ADMIN DUE 

NEGOT 

PROJ 

DATE, OS/22/97 

DATE, / / 

DATE, !! 

DP BC 

226708 

226709 

.I / / 

/ I I 

/ / 

/ 

/ 

* * * DATA REVIEW INSTRUCTIONS * * * 

This product is recommended for reregistration upon your 

final revie ... ; of label for compliance with Ethephon RED. 

After label review, please close this data package 

submission as well as the 674 submission with a 

reregistration decision and file all correspondence in the 

product jacket. Thanks 

correspondence/administrative 

product chemistry/acute tox reviews 

.- * * DJ:3A PACKAGE EVALUATION * * .-

No evaluation is ' .;ritten for this data package 

* .., ..- ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION *' * * 

BRANCH/SECTION 

RSB/PCRS 

RSB/PRS 

DATE OUT 

05/31/96 

05/31/96 

DUE BACK 

08/29/96 

08/29/96 

INS 

Y 

Y 

CSF 

Y 

Y 

121 

I 

LABEL 

Y 

Y 
• 

• 

• 

DATE OUTI 

SDBJBC'l" BP [X] liP [J PRODUC'l' CBBIII8TRY RBVIXW 

TO. 

PROII. 

TlIRU: 

DP BARCODB HO.I226708 RBG./pile Syabol Ho., 264-418 

IIBGI8TllATrOB [ ] RBRBGl:8TIIA'I'IOII [X] RBRBG CABB BO. 0382 

PRODUCT &JIB: Prep Plant RegUlator lor Cotton, 55. 4t AI 

COllPUY.Rhone-PllUlenc Ag COIl!!1IDY: IIBCBIVBD DAH. 01123/96 

BRID B08.439205-04 

22 Cynthia Giles-Parker/Wanda 

Fungicide-Herbicide Branch 

Registration Division (7505C) 

Ruffin Daughtry 

r J -'~? r;;,!L- sami Malak, Chemist, 11/12/96 (308-8392) ~7- ',iY , 

Product Chemistry Review Section u/ /J,{ I'" 

Registration Support Branch/RD (7505W) t (;..U",L.-'· !,IL 

A «""v I, 4P "", Harold Pedall, Section Head d P J~ Itt""""'-

Product Chemistry Review Section 'I' 

1. The submitted product chemistry data requirements for 

reregistration of this end-use product, Prep Plant Regulator 

For Cotton, Reg. No. 264-418, is aduate. 

2. product chemistry data requirements pertaining to Series 63, 

summarized in the table below, is adequate. 

3. The submitted product's label EPA received 1/23/96, is 

acceptable. 

~, The s~mitted produot~s C$F, a. basic formulation dated 

12/19/95 is acceptable, 

All ingredients are cleared tor use in ·pesticide formulations. 

RlCOHMIHDATIOIS: 

We have no objections to reregister this end-use product, Prep 

Plant Regulator For cotton, Reg. No. 264-418. 

122 
• 

• 

• 

2 

SUMMARY OF PRODUCT CHEMISTBYDALi REQUIREMENTS OF SERIES 63 

fflYSlCAUCHEMlCAL PROI'ERIlES. MBlD No. 4392IJ5.!H 

GUIDELINE VALUE OR QUALITATIVE DESCRIPTION 

REFERENCE NOI7T1'LE 

63-2 Color Water clear 

63-3 Physical State Free flowing liquid. 

63-4 Odor Odorless 

63-7 Density. BuIJ: Density. 1.3045 

or Speclftc Gravity 

63-12 pH 1.69 

63-/4 Oxidizing Or Does not contain oxidizing or redudns agents. 

Reducing Actum 

63-15 FlammabUityl Flame NA 

Extension 

63-16 Explodabl/ity Does not contain any explosive mateTinTs 

63-17 Storage Stability Stable for a minimum of 1 year. 

63-18 Viscosity 7.838 cSt 

63-19 Miscibility (With NA 

hydrocarbon 

Solvents) 

63~20 COTTOsicn Non corrosive to stainless steel or plastic. S/Ight corrosicn 

Characteristics to mOd steel and aluminum. - 63-21 Di£lecrrlc Breakdown NA 

floltnge (EP only). 

ee: saml Malak end Cont~.l file (Reg. No. 264~418). 

1505~:RD:RSi:PCR$:C$-1:650:S.K.tak:11/12!96:70l-308·8392:<264·41B>. 

123 
DP BARCODE: 0226708 

CASE: 003396 

SUBMISSION: 8499337 

DATA PACKAGE RECORD 

BEAN SHEET 

DATE: 05/31/96 

page 1 of 1 

• * * CASE/SUBMISSION INFORMATION * * * 

CASE TlrPE: REGISTRATION ACTION: 674 8 NHTH RESP-PROO SPC DATA 

RANKING : 

CHEMICAlS: 

o POINTS () 099801 Ethephon 55.4000% 

10': 000264-00418 PREP PLANT REGULATOR FOR COTTON 

COHPANlr: 000264 RHONE-POULENC AG COMPANY 

PRODUCT MANAGER: 22 CYNTHIA GILES-PARKER 703-305-5540 ROOM: CM2 229 

PM TEAM REVIEWER: WANDA RUFFIN DAUGHTRY 703-308-8171 ROOM: CSl 1K4 

RECEIVED DATE: 01/23/96 DUE OUT DATE: 07/21/96 

* * • DATA PACKAGE INFORMATIOK * * * 

DP BARCODE: 226708 EXPEDITE: N DATE SENT: 05/31/96 DATE RET.: / / 

CHEMICAL: 099801 Ethephon 

CSF: Y LABEL: Y 

.: 

TYPE: 001 Submission Related Data Package 

SIGNED TO DATE IN DATE OUT ADMIN DUE 

NEGOT 

PRQJ 

DATE: 08/29/96 

DIV:RD // // DATE: 

BRAN: RSB / / / / DATE: 

SECT: PCRS / ~/ / / 

:R; ~ ~ ~ 

• 

* * * DATA REVIEW INSTRUCTIONS * * * 

Please complete 8 month reregistration review of product under Ethephon RED (0382). Thanks 

Attached: 

MRID 43920504 FOR SERIES 61, 62 AND 63 

PLEASE RETURN TO W.DAUGHTRY, CS1, 3RD FLOOR, SRRD-7508W 

* * * DATA PACKAGE EVALUATION * * * 

No evaluation is written for this data package 

* * • ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION * • • 

~ ~ 

DP BC BRANCH/SECTION DATE OUT DUE BACK INS CSF 

124 

LABEL 
• 

• 

MEMORANDUM 

UNITEO STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D,C, 20480 

OFFICEOf'" 

PREVENTION, PESTtclOfSAUD 

TOXIC SU6STANCeS 

Subject' EPA File Symbols, 264-263(0226719), 264-543(0226721), 

264-267(0226711), 264-292(0226717), 264-376(0226715), 

264-257(0226723), 264-377(02267291, 264-380(02267261, 

264-418(02267091 & 264-511(D2267061 

From: t4ark J. Perry, Biologist 

Precautionary Review Section 

Registration Support Branch 

Registration Division (7S05W) 

To: Wanda Ruffin Daughtry 

Special Review and Reregistration Division (7S08W) 

Applicant:Rhone Poulenc Ag Company 

P.O. Box 12014 

2 T.W. Alexander Drive 

Research Triangle Park, NC 27709 

BACKGROUND 

Rhone Poulenc Ag Company has submitted or cited acute data 

for several products (listed above) in response to the Ethephon 

RED. The products are addressed in accordance with the acute 

toxicity batching strategy included in the RED document. 

Ethephon is a plant growth regulator used to promote fruit 

ripening, flower induction and other similar responses from 

treated plants. 

RECOMMENDATIONS 

Batch 1: EPA Reg. Nos. 264-263 & 264--543 

81-1: Category IV (MRID 439205-01*) 

81-2, Category III IMRIO 439205-03*1 

81-3: Category IV (Based on ~echnical) 

81-4, Category III (MRID 418674-011 

81-5, Category IV (MRIO 418015-011 

81-6: Non-sensitizer (Based on Technical) 

* MRID 439205-01 and 439205-03 received an abbreviated review due 

to the results of the acute oral and dermal testing on 

technical Ethephon. 

125 
• 

• 

Batch 2, EPA Reg. Nos. 264-267, 264-292 & 264-376 

81-1, Category III (MRID 439205-02*) 

81-2, category JIJ (MRID 439205-03*) 

81-3: Category IV (based on Technical) 

81-4, 

The eye irritation study cited to support this requirement 

cannot be located (MRID 00070086). As a result, 81-4 is a data 

gap for, the batch 2 products listed above. The registrant may 

choose to submit a copy of the cited document for review, or cite 

alternative eye irritation data to support reregistration of the 

products in this batch. 

81-5, Category III (MRID 00251542) 

81-6: Non-sensitizer (Based on Technical) 

* MRIOs 439205-02 and 43920.5-03 received abbreviated reviews due 

to the results of the acute oral and dermal testing on 

technical Ethephon. 

Batch 3, EPA Reg. Nos. 264-257, 264-377 & 264-380 

81-1: Category III (Based on Technical) 

81-2: Category III (Based on Technical) 

81-3, Category IV (Based on Technical) 

81-4, Category I (MRID 002486Sa) 

81-5, Category II (MRID_00251S42 & 00248658) 

81-6: Non-sensitizer~,(Bas8d on Technical) /" \ 

Batch 4: BPA Reg. NO~. 264-418 / 

81-l, Category 

81-2, Category 

81-3, Category 81~4: Category 

--~ -~</~-

II:L-tBased on Technical) 

III (Based on Technical) 

IV (Based on Technical) 

I (MRID 00248658) 

Due to the category I eye irritation observed in a 39.9% 

batch 3 product (MRID 00248658), PRS has decided to use this 

study to support the subject (55.4t) product. 

81-5, Category I (MRID 428727-01) 

81-6: Non-sensitizer (Based on Technical) 

Batch 5: EPA Reg. Nos. 264-511 

81-1: Category III (Based on Technical) 

81-2: Category III (Based on ~echnical) 

81~3: Category IV (Based on Technical) 81~4: Category I 

Requirement waived due to expected severity of eye 

126 
• 

• 

irritation testing results. 

81-5, Category I (MRID 00029513) 

81-6: Non-sensitizer (Based on Technical) 

LlIBELING 

Batch 1: 

1. The recommended signal word is caution. 

2. The recommended precautionary statements are as follows: 

Harmful if absorbed through skin. -Causes moderate· eye 

irritation. Avoid contact with eyes, skin or clothing. Wear 

long-sleeved shirt and long pants, socks and shoes and chemical 

resistant gloves (such as Nitrile, Butyl, Neoprene, and/or 

Barrier Laminate). Wash thoroughly with soap and water after 

handling. 

3. The recommended statements' of practical treatment are as 

follows: 

IF ON SKIN: Wash with plenty of soap and water. Get medical 

attention. 

IF IN EYES, 

physician if 

Batch 2 

Flush eyes with plenty of water. 

irritation persists. 

1. The recommended signal word is caution . 

Call a 

2. The recommended precautionary statements are as follows: 

Harmful if swallowed or absorbed through skin. Avoid 

contact with eyes, skin or clothing. Wear long-sleeved shirt and 

long pants, socks and shoes and chemical resistant gloves (such 

as Nitrile, Butyl, Neoprene, and/o~ Barrier Laminate). Wash 

thoroughly with soap and water after handling. 

3. The recommended statements of practical treatment are as 

follows: 

IF SWALLOWED: Call a physician or Poison Control Center. 

Drink 1 or 2 glasses of water and induce vomiting by 

touching back of throat with finger. If person is 

unconscious, do not give anything by mouth and do not induce 

vomiting. 

IF ON SKIN: Wash with plenty of soap and water. Get medical 

attention. 

127 
) . 

• 

• 

Batch 3 

1. The products in this batch meet the criteria for restricted 

use classification due to eye irritation. The PM Team should 

decide if restricted use classification is necessary or if 

alternative labeling will allay the requirement for restricted 

use classification. 

2. The recommended signal word is danger/peligro. 

3, The recommended precautionary statements are as follows: 

Corrosive. Causes irreversible eye damage and skin 

irritation. Harmful if swallowed or absorbed through skin. Do 

not get in eyes, on skin or on clothing. Avoid contact with 

skin. Wear coveralls worn over short-sleeved shirt and short 

pantst socks and chemical resistant footwear, goggles or face 

shield and chemical resistant gloves (such as Nitrile, Butyl, 

Neoprene, and/or Barrier Laminate). Wash thoroughly with soap 

and water after handling. Remove contaminated clothing and wash 

clothing before reuse. 

4. The recommended statements of practical treatment are as 

follows: 

IF SWALLOWED: Call a physician or Poison Control Center. 

Do not induce vomiting. Dririk promptly a large quantity of 

milk, egg whites, gelatin solution, or if these are not 

available, drink large quantities of water. Avoid alcohol . 

IF ON SKIN: Wash with plenty of soap., and water. Get medical 

attention. 

IF IN EYES: Hold eyelids open and flush with steady, gentle 

stream of water for 15 minutes. Get medical attention. 

5. NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate 

?fo---use~gastric lavage. 

(' Batch 4 / "- ..... 1. T1'i'e--"products in this batch meet the criteria for restricted 

use classification due to eye irritation. The PM Team should 

decide if restricted use Classification is necessary or if 

alternative labeling will allay the requirement for restricted 

use classification. 

2. The recommended signal word is danger/peligro. 

128 
• 

• 

3. The recommended precautionary statements are as follows: 

Corrosive. Causes irreversible eye damage or skin burns. 

Harmful if swallowed or absorbed through skin. Do not get in 

eyes, on skin or on clothing. Wear coveralls over long-sleeved 

shirt and long pants, socks and chemical resistant footwear, 

goggles or face shield and chemical resistant gloves (such as 

Nitrile, Butyl, Neoprene, and/or Barrier Laminate). Wash 

thoroughly with soap and water after handling. Remove 

contaminated clothing and wash clothing before reUse. 

4. The recommended statements of practical treatment are as 

follows: 

IF SWALLOWED: Call a physician or Poison Control Center. 

Do not induce vomiting. Drink promptly a large quantity of 

milk, egg whites, gelatin solution, or if these are not 

available, drink large quantities of water. Avoid alcohol. 

IF ON SKIN: Wash with plenty of soap and water. Get medical 

attention. 

IF IN EYES; Hold eyelids open and flush with steady, gentle 

stream of water for 15 minutes. Get medical attention. 

5. NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate 

the us~ of gastric lavage. 

Batch 5 

1. The recommended signal word is danger. 

2. The recommended precautionary statements are as follows: 

Corrosive. Causes irreversible eye damage or skin burns. 

Harmful if swallowed or absorbed through skin. Do not get in 

eyes, on skin or on clothing. Wear goggles or· face shield. Wear 

protective clothing and rubber gloves. Wash thoroughly with soap 

and water after handling. Remove contaminated clothing and wash 

clothing before reuse. 

3. The recommended statements of practical treatment are as 

follows: 

IF SWALLOWED; Call a physician or poison Control Center. 

Do not induce vomiting. Drink promptly a large quantity of 

milk, egg whites, gelatin solution, or if these are not 

available, drink large quantities of water. Avoid alcohol. 

IF ON SKIN: Wash with plenty of soap and water. Get medical 

attention. 

IF IN EYES: Hold eyelids open and flush with steady, gentle 

129 
• 

• 

• 

stream of water for -15 minutes. Get medical attention. 

4. NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate 

the use of gastric lavage . 

130 
DP BARCODE: 0226709 

CASE: 003396 

SUBMISSION: S499337 

DATA PACKAGE RECORD 

BEANSl!EET . 

* " " CASE/SUBMISSI~';FORHATION* * * 

DATE: 05/31/96 

page 1 of 1 

CASE TYPE: REGIS'l'RATION ACTION: 674 8 IIII'rH RESP-PROD SPO DATA 

RANKING : 

CHEMICALS: 

o POINTS 0 

099801 Ethephon 55.4000% 

10': 000264-00418 PREP PLANT REGULATOR FOR COTTON 

COMPANY: 000264 RHONE-POULENC AG COMPANY 

PRODUCT MANAGER: 22 CYNTHIA GILES-PARKER 703-305-5540 ROOK: CK2 229 

PH TEAK REVIEWER: WANDA RUFFIN DAUGHTRY 703-308-8171 ROOK: CS1 1K4 

RECEIVED DATE: 01/23/96 DUE OUT DATE. 07/21/96 

" " " DATA PACKAGE JJlFORKATION " • • 

DP BARCODE: 226709 EXPEDITE: N DATE SENT: 05/31/96 DATE RET.: / / 

CHEMICAL: 099801 Ethephon 

~ TYPE: 001 Submission Related Data Package CSF: Y LABEL: Y 

SIGNED TO DATE IN DATE OUT ADMIN DUE DATE: 

DIV:RD // // 

BRAN: RSB / / / / 

SECT: PRS / / / / 

REVR: // // 

CONTR: / / / / 

NEGOT DATE: 

PROJ DATE. 

" • " DATA REVIEW JJlSTRUCTIONS " " " 

Please complete 8 month rereqistration review of data 

product under Ethephon RED (0382). Thanks 

81-1 and 81-2 citing KRID 00257032 

81-3 citing KRID 41685901 and 00252902 

81-4 PHS gave approval for registrant to cit .. data ~conducted on 264-380 (MRID 00116670 and 00248658) 81-5 citing MRID 42872701 

81-6 citing KRID 00151056 and 00257032 

08/29/96 

~ ~ 

for 

PLEASE RETURN TO W.DAUGHTRY, CS1, 3RD FLOOR, SRRD-7508W 

DP BC 

226708 

* * * DATA PACKAGE EVALUATION * * * 

No evaluation is written for this data package 

" • • ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION • • • 

BRANCH/SECTION 

RSB/PCRS 

DATE OUT 

05/31/96 

DUE BACK 

08/29/96 

INS 

Y 

eSF 

Y 

131 

LABEL 

Y 
, Unft&d S't8t8t IIW'irotmmlUf Protection Agency Fofm Approved . 

w....,..",. DC 20460 OMS No. 2070-

0107, , CERTIFICATION WlTH RESPECT TO 2070-0057 " DATA COMPENSATION REQUIREMENTS ApptOVid Expires 3~3,·96 

Public ro,oortino Curd., for th~ oo/lOO'l:iGn of infafTl'\Otkln 10 fttimatfK1: to ~G. 15 mirlutG4 per rooponoe. itJcludlng ti:tnn for 

reviewing il1structlOnl, searChinG oxmttng data sourcer. Ofthemg and maintaining the data nOGdod. and compllltklo and 

reviewing the coll&ction 01 ilformatiOo. Se.1d commeott IWQ8t<tino the buroon '8fti'nat4I or any oth« Uptlct of this cotIaetk:tro 

of infonnation, indutSinO SUOgatiOn!: for reduclno this bunkIn to. Chiaf lritormatloo Policy Branch. f'M..:l33. U.S. 

Environmsrrtal Pr01tc:tlcn Agency, 401 M St., S.W., WMl)in;Con, DC 20460; and to the Office of Manaoement amf Budget. 

Paperwofk Reduction Pto;oct (2Q7()-o1061. WuhnQ'tco. DC 20503. 

pte ... fill in blanks b8klw. 

c: • ....,. .... yN_ Comp""V N" ...... 

Rhone-Poulc:nc Ag Company 264· 

!",oduet N.",. EPA Reg. No. 

PREPTl~ brand Ethepnon fOf Cotton and Tobacco 418 

I CGrtify that: 

!. For .. en study cited in SUppOrt of rOiPstration or ret'egistratiion und .. the Federalinsocticide, Fungicide and Rodenticido 

Act (F1FRA) that i$ an fXclusive us& stUdy. I am the onoml dBtu submitter. Of I havo obtolnod the written plN'lTlilsion of tho 

original da'tllvubrntttet to cite tha1 mtdy. 

2. That tor eaCh study cited .In support of legisttation or...-.gistration under FIFRA that is NOT an exclusive use study, I 

am the original data submittllr, 01 I IlAve obtained the writta'l p~ of the original data aubmitt8f, IN" I have notifi(ld in 

wnting thO eMJpanYlirIIl that submitted data I have cited and hi .... of'ftnd to: fa) Pay cornpensatjon for those data in 

accoroonee W1tn sec:t1ONi 34CJllllFI and 3Ie)l2)IO} Of fIFAA; and (b) Commence n&got.lion to Cle't8n'nntt Which Cktia are 

subject to tn. compenc.ation requitement of flfAA and the amount ot eomperu;ation due, if any. The companies I have 

notified are. Icheck onel 

( I The companias who have eubm/tted tho studietJ listed on the back of this form or ett8Chod diem;, Of indicated on tho 

machod ~RequirGm."t$ Statu. and Reoifmtnts' Raspooae Form, ~ 

3. That I have prmousty complied with Section 3(cl(1)IF) (If FIFRA fortM ltUdlesl have cited In support of raglstmtion Of 

fet09istmlon undet FlFRA. 

SlQnlMO 

/~;(;:; ;j,2;!t'/ 

Otto 

.1/ j/7 L, 

NIImO II(>d TIlio iPl .. u TYllo C<t fl'nnll 

Ga i 1 Powell, Regi str'ation . manilger . , 

GENERAL OFFER TO PAY: 1 herebyoffor and ogroo to pay oomr;ttne!l1ion to other PO,..GnS, with rngilrd to the 

rt'gistration 0( rereoisttation of my productS, to the extent required by AFRA semion 31cll111Fl and 3{c}(2HOI. 

SlIlMlUr. • 

~/~d/ ;,i;1 :1t-,4 ... ,. ' 

- N_.m Tlv. iPf ..... ryp, Of t'MU 

Gail Powell, Registration rlanager' 

, 

132 
• 

• 

£l'A fUe 5""",,[/Rea. tb. _-,2",6",4·",4",1",8 __ _ ::lata or Iloolieat.lal ____ _ 

..... of Pr::c!uct: _-,P.;;R",E,-P t_m-"B",RA",N",D,-,-ET",H",S"P",HO",Uu;E,.ORc...J.C",PCLTI.uO..,NI.JlA.,NDJ.-'I"'08wAIJ,C.l.CI.lO ___ _ 

ADolicam::'s u.... and Address Rhnoe-pouJQQC 49 Company 

P. O. Box 12014 

ReSearCh Trjangle Park N C 277Q9 

1. This &;IPlicat.ion is ~ by all dau lNt:Iaiu.ed or cited in the 

applicat.ic:n. In addition. if c:ite--4l1 ~ions are irxiic:aud. this .~ic:aticn 

is sucponed by all data in tlUI Agency's files that concern the propertt" 

or efteees of this ort'lduet or of IJW otIWr oroduet tl\at 1.1 ictent:.lcal or 

aucstAnually sUailar. anc1 that is a. of tna types of dat.a that WI:IUld be 

AqUirec1 to be II\CIltted if this a;tplication IIOl.IiJt\t the initial nqistration 

of • produc:c. of idenuc:al or .war c:C"""lIldon en::l intandeC1 uses un:!er 

the d.tta requitatwtntoS 11\ effect at the ~at of ~al. of th.is epf11ic:aticn. 

2. r certify m,at.* for each swcty cited in supoort. of this appl1cat.ion 

!or requtrauon that 1s an exelUS1" UN aCJdy. I have obtained t!'le 

wt'1t:.'!en pemlSS1c::n of the orlQinal data autaitter to Clta t.hat seudv. 

3. r certify that. for • ..ch study eit.ecl in supgort. of this atlOlicuicn 

for t'egl.$uation that is ~ an uclusivoe use atl.l:ly: 

r have Obtained d1e 'W"t'"it.ten pem.ission of t.tw. oriqina1 data sutmitter 

to cite that ST:Uay': ~ 

r have nOclUed in writin; the CXJ'I!q:I&nies wno have tNbSitted !'!au I have 

cited to SUCD01'1:. t.I'Iis aopl.icaeion and haft offered to: (a) Pay ~Mation 

for .- data in • __ with .-ion 3(c)(ll1D) and 3(0)(2)(D) of 

the """Rl, Il'tRCt:tci6,,, fUngieide &N:I AodeIKicidlt Act: and: Cb) OJa.nee 

MQOt.iationa t:o deteDllirw \It\ic:b data .. IlUbject to the 1X:iiII*'WAtUxt 

requi,&i&h't of FIFRA and the II'Dltlt and tam. of CX2'IIpeI'INdcn due. if 

any. the CCDIpImies t h.ne notified an: (c:neck. c::JrW) 

~ All ~i .. lisud on the Peltit;:ide c.u SUbl:itters t.1.st for 

&11 actlve in;ndittrWl c:cneained in my ~ (C1C.-.ll lIIft.bOd or 

eiu-.ll opeion um.r S.l~l.ve Ket:hC:r:I). {Also sum t:he (itlnerel 

Offer to Pay Stat:IIIIeM bel.ot.) 

I<J 'IIlOM c:aoponi .. _ l..w. _<<ed the ._1 .. wtrlell I "... 

ciUd (Sllecive _UlOCl) 

""to 12/ zrirr r· 

Registration Mavager ..... • •••• 

....... 

• • , ••••• !t • • 

I he'-"~ offer and _ to -... iii Me-1Cll to 

~;rnr-;'';';;d';'' tho ..-"".1 of th1s~"",I1"'iiS\'~ to !:he,:' - roqu1_ by FlFJIA """. 3{e)(1)(DI ":~(2)~ d' -:.'.: 

""... {"/ ?Zb;- Sianatw:lt Jf&,..1I1W<-~ , r ' • 

Title i{.;u /ryiim.jl{ry'Y"j'X:"· 

(1<>rU 1985) 

...... . .. .. , 

133 
... '"m .'" .OMB No • 

United StateD _ Registration Numbltr 

&EPA Environmental Protection Agency ..i Amendment 

Wuhlflgt:on. DC 20460 251318 _ Other 

!for - • I 

. CompanyfPrcduet Number 2. EPA P,oduot MaflilQM 3. Proposed ClllHlficallon 

O<A. "0 '<ow. [ij"- o Rntric.ted 

4, Compony!Ptoouet (Nomo) PREptm BRAND ETHEPHON PM' 

#22 .:.- 00' t (Include ZIP Ccd,d 6. Expedited Rovlew~ In 3Ccordance with AFRA Section 3(c)(31 

Rhone-Poulenc Ag Company (bj{i). my ptodtJ(lt Is sImllaf or identle:alln composilion and labeling 

to: P.O. Box 12014 EPA Reg. No. Triangle Park, Ne 27709 1 aha« if thi!J is • nilW tKidT4u Product Name 

SOC rton - II 

~ Am.""""". ,,,,,,on b"ow. D Flnal printed labol, in ro8pGnH to o Aaaney JaUilt datod 

Rewbm/.aion In totpOnftl to Ag<l'fWy loU<1t dlltod -M6 TO(,J" Apptfoatlon, 

[ "otWealien· Explain below. o Other· ExpiO;in b%w. 

UItO eddltional pagala) If Meo,oaf'(. lRir .oetion I and Sltction n.} 

Revisions to label as required by Ethephon RED, April 28, 1995 

Added "Do not mix \'Ilth Armnonium Thiosulfate Statement" 

Modified statement about "do not apply if rain is expected" 

.:J!!. 

11. , .. , , ." Peck$gino !""'" ,-

Peekaoing 2. r.",. of Contalnet 

1,,8::°' - Yeo v" I N. [ No ~M". Pla.tlc 

Glao. 

mU$t I ~~ir.'':, Nt.. pal If -v.,- No. per P."" 

wgt. eonl4!net Pack&ge wgl oonlaitat Olhot lbe-

, 

I'~~-~' I'.' '0'""" " R ... 

I III Lob$l 0 CGnlluner 1, 2 5, 5.0, 30 110 produo:\t 

6. Mannot In Which Label I. Afflxotd to Ptoduol I- ~~~~. UJO- ., , ,A 

iner conbin< label 

• -IV 

1. CO"'~"o;n' 'ro.o , to prno~ this, 

'"'Gail I Tl •• Ate, Code) 

Powell Registration Manager 919/' 

Certification ":~: 6.0ilb/Applleation 

I oertify thallhG mlomonl. I have mocl, on IIUII- form ood &II attaohmanw IhorelQ .,. lru', 6¢¢Ulate and c~. !<'Gotv' 

I I1l4teme"t ffaV be punishabfe bV fin. Ot ImprillQnm4nt Ofl' : 

, 

• (k'lfmpedJ 0;;'.-'''''0<' .. • , , ... .. 

2.0""";8 J IZ ~ j j 

3. Title .. : .. ' , 

Registration Manager , -, , - , •••• 

4. T'iJ)ed Heme 5. Dale , • ••• , , .. , 

Gai I Powell 12115195 1 ':lA 

"'A~"'V,"'" ....... M 

-. Cop, Copy 

, 
~--"----

PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

('- : ;:' , " ~ 

PAPERWORK REDUCTION ACT NOTICE; Public FI.>pordng hurthn (Of lW$ Milcction af InfQrmlition!$ I1Hl~l4d to 1'I\lor~ 0,85 hour p!!>f 

rOSjmI'l$O.I~ time for reviewing ilWw;;-&m;, lifMUQNnQ eldlitinu dillS 'loom"$, Uillh6ring lind mmnwlninu itm data Mmlad. lind eompllHll'tU Iffi<'J 

rt«k:owlna Itw ooifIMtWn of !nfIJrmaliof!. Send eOi'1lrfW!lllll 'II'g&rmng 1M btird!tl) otttiml!!9 (jf ~51'<Y Qt~r 3l:jt'l'Ct of lhill ocllox:.ticn of il'l/orm&thm. Imludil1g 

iW\l~l:tlmijl: f(;f riduclhJllhia- burdtln. to ChillY, InftirrrtMJ<.m Pelley lJrtmcn. 121 JSL lUL fnvirOrlm$ntcl pff)t,,~tlon AU!irwy, 401 M Stro:et, SW, 

WMhingtOh, OC' 20400. 

~:.~~:~~= Thi. form iv to be used lor d1 appliclltiun!t for now r<tgi1.tuflon, eM uw. forogiSlftltiQfl, bf'landmKIt. fgwbmiulon, to UPP#(lllll1:m1l 

printed Iab-.Una, flirtlgislnltitU!, etc. In ordllr to prac(llIs tin Ilpplieilllll;ln (or "ntlW reglstration llUbmiued on this form. the 

mtwt ae~ny tho tipplha&n; 

1. Cn$ution' with f\oeplWt to Cltatkm "If Data iEPA Form 8570-29j. n( flot i.t>(arr;ploo by 40 ellR 152.S1 rbl 1411; 

2:. C~ Statemant 01 FOffnUfIl IUA F«m 8510.4jl 

3. F¢mWJatof'. Extm"lptiofl Sutorrwnt IEf>A Farm a57o-271; 

4. Ave GQpi •• of dreh IISb~; 

5. Tht .. o~ of any datfl aubmllted; 

6. Aulh4ti141lrm IOUOf WM~ app'Jnlbfo; 

7. Mtltrlco, where appIh:ablo. 

of l.ah.tmg • lal»!lng $howd flrllit bo oobmitted'n the form 01 arllft labula wilh WI l!pJ)IIeatioM lor Mill' fegi.lfation. Suoh dralt llI'bclu may bill 

leJffi text 01'< 8.5 x 11 ineh ~ fOf lWbmili'1rion Of It fMlekup of Ih. ptep(l1I4d lebel, If Pfapilf«l fOf moekup. it lihGuld be 

WilY Q to' fbe-IDuto stOfnijO In liIn 8,5 x 111M» f1!d. Mowup looeh IlgrJr,/j/ilnuy tmaller Ihan 8,5 x 11 lMh ... hould be mourned 4n 8,5 

(Of 1Il.!!.m-Jse1on. 

Dau· Oal4 lJuumitted In $UPport of lhill ~Iill(;(llion I1I!J1It ba lIubmltl0d In t!(!cordnff\!e with PR NOllee 8G·5. 

1~!lillIlQli!- This lIeclion mu~1 bll tomplMM. '" appHetIWlI. lor fill .tyi$lrlllkm action.. 

1. CompaoylPfodual Number· lmiert your C{)I'I'!p1llnY Number, If O'ne hill\l, tHHm $!imgl'!ed by EPA< ThilO number may hav .. bdcn 4a$lgnod 10 vcu M <l 

1;11.1.:,\ foglll!r<mt, • di"t,lbutof, or n. 4ft tHlllIIbfi1oftn'wnt. If)'Ottf (If<xluot 16 ftlwsum4, InS<f1t ltllt Product Numb.t. 

2, 'EPA Ptoduct M]Mljgu· 1/ kMwn, rm in tOO Mm¢ and PM nvmmu O/IM EPA Ptod-u411 M41na~r. 

3. PtCflOHd ~atkm ~ $pwly Ihtl prQPoll!id clll!lMfielliiofl <)1 thW produot. 

Product N4tM • Cnt$f the lXlfflP/$1w pf(uJum !'ll'IfWJ of this~" In it wUl J;j)pH( on the IshL The NIITI'II mullt Ia ~ to tWA ptoduM rmly. 

Ou.tkm of /iGI'l'IU I; Mt POfmtUnd &rIWnu prodW;lll. 01 \ht- SlumO t;orrtpbny. Do !'Un Incll4do GAy brand ntltml or ~ fiMl d~Gf'l$, 

5, Nana and A~ 1'{ AppUHnt· Tn. ffiI!nl! or tN firm trr JWfS{;lO lind lIlddr~u 'Mwn In your application hi' tM pO}tUIn o/fl® to )V~ the 

rcghrtrotion wm b. IUlJmi. If you M# ru:lIJI1Q in bflhW( M tlnolilsr PMty, you ."-WSI QUbmlt lru\Mliution trom lhat pMty tt! m:t tor thOrn In n~Wtltrlltien 

matt.,.., An IIIPpfiOlint not flttkflng In the Vnitlild StatO$ must h\lvO an euthoriu4 *trt ta$kling In Ih. Urnlmf SUit" to act (w tmrn In "dl 

r&glStfliticn martel". Tho IlUM 4nd coftlPfelv mcillng liddre;" o( wch tin llGt'nt !'mist ~an'f 1m zpp!¥:uti!l~. 

E:qadit4tl n.llkw ~ F1FRA ~tlon 3- (ciS (S) prov\dh fw o;qadlWd ftviaw e13pp!iClf~ Jet( u:oi!.l'lrlltlt;m, Qf armmdmllft{sto ,~,.'''' ,.';w .. , that Mit Milltlf ot idtlntkltd to ather PMlticldo PrOOutt!l Ihtlt {ft. currently fOiP1rtornd wllh iJHj EPA. In order fllf yoor iIfIP!leo1i((n to hll 

expediud review, ~ mu$1: pfovkfJ.l U$ with lftn EPA Reolufa:!on Numbnr and pto4uct I'tijffitJ of thli pmdu-ct 'IOU bdew 1e ~ to ,,~'"tl'" 

YOUf pfudlJC't. TIa produCI must t;., .Jmillir 01 idorrtie~ kl both Icrmu!&tioo and IlIb{lltld U§fll. 

~~~~~~.:·~ThI1I: !li\UJion ml.Ult bIJ lXmlPfolttd ror eiI ~lIti'H,\' zubmJusd to emond tho f#WSITiiUK-11 Qnty fit " CU"«ltly ~at«od p«!>duct lor III rqlNhrr!lslliQn if! f4!!p0ffll. 10 lin AuerniY letlllf, lor "o-lifiallilcra to 100 Ag¢tU:ly, lor lhe 1IVbmi~ cUIfill' printed lllbaUnu. fIX" 

fer any bthH "tion: lMI pnta!MI «> (I pP!!llifle R?A·rtW*I!![r-4 prMWlt. "ihhI Melien 1$!l2.! 12 k! uJlod'h)r .. new ~atkm fot 

1. ~t of tubmIHkm« Ctui-ck tho ~l,l4hlll Woe" and Ptow.l1~ I/;/I' Aj:J91\C)'.I<oIlUot 43Ut ,ilItPIUc-priat9. Frcvtd. Itbtll'll expl_ti<m (t/ the putp(\{I4I~) 

fOf tho aubmisskm. wah 011 -Om additi"n af a mill, p!W1 (If or .... ,? iltpl)cdy)~; ~arrnmd tho Confldllntilli SUltmlwnt of Ycfflm/o by"."; "fefeWlllmt(cn 

:lubmiHkn"; -QWafD/lbbei ro\4tlon of IN'" dtrllctlont:. ~ Atttwh tI l16ptlfaf9 {Mite ileddiuonal $pllce III nheded, 

1. 

2. 

'" 4" 

5. L_tfOl1 cl 

6. Mllfl-IWr in 

CuntaiM-' IllfotflVltlcn}· Thl1. Soction mtl~t bl< c~~llIld (Ot dIl aPf}liclIIh,>n& .ubmittoo tn COffM\CtiOf) with now 

11 y¢lJ( pre-duct will he- pllck&g&d In the- itWlcaltld packaging tvP*1I, 

~~::'~,:~~rrurnb'r pili retail comllir>IIL eOl'!tmMf In wI-Jell. pn:.0ttct W#I OJ'! fWlrht<l!d, 

of tfuJ MI eQl'1hlflt$ inforfwnioo tor VOUI pf>MUcr. 

Mt oont9f\-l$ (}I @lI fe-uri <:xmt&l/Wffller VWf prWuot. 

location 01 the U~ilI dlf(KlliolW fer yi;i\lf prtlduec 

IndWat&d Ih5 fTh)thod prOOtic! lab,u 15 ;nmctw-d to tatllil eonUilfWIt. 
Fo~, ,,,... OM. No. 

, Unlted State. Registration OPP Id.l'ltlft.r Numb.r 

oEPA Environmental Protection Agency ::L Amendment 

Wethlngton, DC 2.0460 251318 Other 

, for I - I 

11. CompanylP,oduet Number 2. EPA Ptoduc:t M4n&g0, 3. PtOPC)l«l Cfualficlitlon 

"''''41 N SH,k" [!]NOI\CI o R •• trlcted 14. CompanyJProduot tN«no) IXi l{\{f;f~i! 'lHePdO" PM. ~, ,i 121 

.0' t Ifnclud. ZIP CorM 6. expedited Review. In accordance with FIFM Section 31c(3) 

'U:~;;i0~ lenc q/ (bUll, mv product Is similar or Identical In oomposltion and labeling 

, 

, 

~ !L dox 1 1/1 to: 

, "i(j·1rqi(; tk f"- , ; ;<) EPA Reg. No. 

r 

,le , i ~ 

I Ch«:k If thk 1# • tlqW .ddrHit : Nam. 

I - If 

~ A~""m'"t·"'''.n'''ow. D Final printed 1&btIlt !tII '''1'004l1li to 

~ Ag.noy ,.u" d .... Resubmi.sion In r •• pons. to AoortGy latter dotlld ·Me Too· Appfuunion. 

-[] Natifloati(){1' Explain balow. ] Othel' explain balow. 

,_ V,e additional PIfIOOIII)If Mile"lIry. Ifor '"tlO(l I end Seetion 11.) 

~~,_:., S '; ons to ] tlb(:i Ss ' , 1(0' i! A:;t; i '" i , ~)!'Qn , , ---. , ,J', c 

Add(:0 " mit mix 'n j til !V,T!JI1; d~' Ihi'Asul16tL " " - , . :>tdtUf;.:,nt 'c ;'4 ;\~ 1 l' j ,:d c,tdlf,'i!'cnt e)0Zmt -'.11) 1\(; t :;:';! 11 !t rain cC 

" ;:Xj)!:::t<'ij" 

I -iii 

". .......... WO .. 

Child·Rofil.tant PackaginQ 

, i r ~~W. ""'woo 2. TYJH of Container t[:" V .. 

~ No IlL N. ~~W i PfNtil;l 

Gin_ 

*" t/onmult 'N' !.': ~_o,:p.r I ~"\ .. " . No. P" ''PM 

IHI aubmlttfld COl'ltalll" wgt Other 

, 

[i] c.:.. .1 N.t ' 

o Container 

c '~""', c ' ;:" '; -- ) :;n ! H, :::3 g;:c~. , .",do" '- ",-,,' -

&. Manner in Which label I. AWnd tq Produot - i~ l1J OihM P 1 iJ'<!-;" :a,",1pil,'t Ij hl1-(i !t, 

",nth'''''' '''fGUinn ,,,!,., 

,- IV 

t ."'"' • .. M"_ fh/$ • 

N~ 11u. ~Ar.aCodOI L9!;," :;,1; 1 fiOht: 1 i -{c,;; is _.14 t -< - t {~!<' ",i !~JtF\'je( 

I 

I 

CGrtify,that 

DCknowllld~ 

tho 

the~~~owinolv 

$tatemonU- I have 

I 

mllda 

... or 

on 

miol'lKflng 

this C.rtlfic.~on form 

.t.t&mant 

and all aUMh!Mnt\l 

may b. JiUni.htlb-le 

th.-rt;to &fD 

by 

trua, 

fin. 

&of;lurato 

or 

::;!~ .. ~ 

both under ) 

2.S,g .. ,",.~!, i 

! , la. lit/a ..f.. .. --• 

i <i>!j-;';'>'~ j;T >\l'1-1,(';" I .... 

" ;' ~ 

.,....Nom. ·:'-1 

,j :"v,,(' : ' .' , 1'l&:: 

' .. 1 .. ' ..... -, Cop, V_ tC",y 
PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

\-

Publ!o fGporung burden for thl, (l"I!,etkm of infcrm.mJOI1I$ ostlmatoo to lIVOMQ<'! 0.95 MU! pM 

limo for tovi&wing iruitructiONI. lMlfl.lhing oxl'll!!nS dijt$ !(lUNC!!, !WIn-ring aM mail1tllininO tho data Mc4Gd. and ~et!ng and 

noH"otien ot il\fQrrNthm. S.nd "ammenla rllgi!lrillou tn, burden e&til:mlll:! Qf 111'1'( OtJaf Mlpocet of thl' ccl/llotion of l/lfornmtio", lMludlng 

re4l1cing thl. b,udon, to Chillf, Into-muilion PQlIe-y annch, 121l6). U.S. Erl\llronmentel Protoction As-nov. 401 M Stu.st, SW, 

DC 20460. 

~~:~:~::~ mil Iwm II to b. lI'W fM all cppne6tlons for new ,,,g:lstretion, end Ullb f61(lijl&tflll:ion, Mrntt'Idmilnt, "UlubrniUtoo, to am:>lie6t1olU 

print'" lalalmg, fefcgilHH;tion, lite. in ord,r to pr(;c.n lin I!f}Plle.etion for. ntlW !%lleuation 1I11bmittod on tN. f01'lT'l, the 

mmt IWCOfflPm'l'{ Ina epplfcat{oo: 

1. C.rtlfieatWn with R.~et to Citation I)t OM. fEPA Form 3510·291, IIf ml! O)(Mriptotd by 40 CFR 152.81 tb) (4)1; 

2. Conlldentl$l Statement of FON'nUIa IEPA FOIffi 8570.4); 

3. FOl'muhttOf'. EXllmption S'l1ltement IEPA Form 8570·27); 

4. Avo eopi .. of dtaft lebeIing; 

5. Thl" copkta of any dat.l wbmlnerJ; 

6. Authorization lenor whore fIWlloab«l; 

7. Matf1CN whete epplloabl •• 

\""'''''''" of LIIb.ltng· t..t>.hn!il IIrnmld tif5t bo flubrrtittod In tflll form of draft 100111, wlth aU eppllC:4tiOrn> fOI new r.g1l1tratbm. Such drllft labds may 

typod label taxt on 8.5 x 11 Inch papfl' for $Ubmlmon or \I' mcekul' of tla ptopotod 14Oe!. If prepared for~. It should be 

,:3~~~~~B woy &s to tooiUtata atonllgo in 1m 8.5 x" inch file, Mockup labets slUNfiesnUy small.r than 8.5 x 11 Inoh •• llhould be moontad on ff» $Ubmjuion. 

Data - Delft #Ubrroittoo in .upport of this !fPplicntion must ba 'ubmlttlld In ACcordance with PR Nollea 8&-5, 

1J!l','&I\flk:I1i~Jl!~~IQ.tl,l;;. Pllla"t; rillad tm. InstrucHoo$ ~lIttld billow b"fore cwnplctinq this Df}p1Icntion, Flut dlltllffllinu tho typfI of reg!IiUafu:ln 

in BloGk A, you ora IWbrniWng tNs Bppllcalion. For IIppjic!lticl1J1l atlbmlttod In connection wlth New RIIQI.tratlon actiona, S*Ctions 

IV rntJSl be eomp!.tlld bV duo applit.:aflt, For IIppllcllItJOns !H)bmlttoo 11'1 coMII:cUon with amllnd!>d r'legistretlon lWtionc. rc&Ubmftlt>oM, I ~,.i""'.'M. tllrcg!.uation" eto .• Seollol'l3 I, II. end IV mUlIt be comploted by th<:lllpplicant. 

tho approprlnte 8(;tlon for which you Mil whmittlng thia form. 

l.i£I:!lQN.l- ThIll ,I.etlan tmJ!lt b, ocmpletod. 6S opplioabl., for 1111 rcgilltrlltlon ootieM, 

1. CompltnyJPtoduet Number· Inurt your Compcny Numl;or, it 0"" 104; baen II$lrillmld by!PA. This numbar m4y have b .. n as~ lC you IS" 

batlc r~"rMI, • dhuributer, or lUI lin flBtoobtvrumt, If your product 1III(I!liSlered, inll6rt the Ploduot tJumbcr. 

2. EPA PTOdwt Manager -If known, fin: In the rum1' and PM oombel of the EPA Produot Manager. 

3. Propoce4 CI_We,lIon· Specify tho proroll.d dauiflc6fian Qf tN, produot. 

4. Product Nal"Ml' tnter IN! eomplattt pr<!duct mime of thill pellUoWc at it wUI OPP04r on tM lobo!. TM rum19 muM b. ,peclID: to' thi$ ptodue-t onlV. 

OI.Ipfiestion of l'I4tmIit ie not permittod (Im(Hlg pnxh.lclll of th, !HlmO eornpliflY, 00 not lneludo any bromd name or eomplU'l'{fil'lO d&5lglllfticns, 

5. N_ and Addr_ of Awli¢Mt -, Tho 1\Mf\!t (If Ihe firm or I'HIIlIQI'I and OOdrus allown In YO\;lr IIppffeeilon i. thtl "orocn« firm to wJwm tho 

regi,tr.tion wUt bc Illsuitd. If yoo are ooUng in boh$f Qf .nothar pony. yeu mUli\! wbmlt ljIJ\horiution trom thtrl party to sot ro:>r tMm in rOQidrlltlol'l 

ImItterl'l, An ""plio lint IUIt r.$MIno in tha United StatMi mull't hillY(! In lIuthorltad *"t rlmding in tho Unltod Satl, to aet for them If'i l1li 

ttolimallon nwtt.ta, The!'I4!"M and cOfflp/eto mtllflnu 6ddr.a, of l\;lel! MI.~nt mutt gcampnny this application, 

ft Expedited Re'ifew • ftFRA section 3 10) 3 IB) plo\lldes fCf expodited r.vl~w of "PpficAtiO(lll for r.glstration, or am4od""";"~":;:;~:~~;:::::':1 that .,e almllar or WentjQal to oth6r pa,tlcld. prool.lct$ that lrr4 mlrrently t4gistOI'lIl'J with tho EPA. tn <lrdor for your.8 

,xpGdlted I.view, yeu must proYkk/ u. with tM EPA R~(Ji"rati(m Number lind Jlroduot rtarfI& of tht produot you believe Is sImRar to or. 

ywr prlXiuct. The product mutt bo limitltr Or identical in brlth formulation lind lafaJed Ul1U. 

~ rn. lHI(ttl~ must b. ~.ttld lor ell IlIPplkulticr1l1 avbmlttod to ¥'niliM tn. regiltullJon oniV of II ClIrrllfltly ~teted prOOuct 

for 8 rowbml![l4lgn In raspomo to .n A~ney letter, for notiflcatjon. til< tho Ag<ilfICv, f"r tho IItlbmi'lIftm of fimtl printed )obetInu, for 

lor MY otMr lrotlon thllt p!.lrtillns ttl II iWru;!lIg EPA·mgl!lgl"d vrooy;t. W ... odon III!!RIm ta u .... d for a MW appIicawm f<>l 

Subjef/t of eubmIHion • Clwcll the IlJPPIlc6ble Woek and providll thll AgillM'{ ilillel dBtOllif appropriate. Pro1!kfo III briof IIxplllNtion of tho !}U11H)$al,1 

lor tho $ubfrn"lon, !lOch IllO "tho oddition of Ii dto, PUt or crop: i~,dtv)~; ~¥fI,nd tho Confidentllll $totem.nt of FofJllUla by .•. ~; ~rer.gistr"tlon 

avbmililSffin~: "g.neral leb$l rovi~hm of u'o directfotl$.~ Att&Ch 0 IlCPluot& P'1Qc If ItddltiGllllillpaOe ill n.$dad • ..... , 

I~~:;;~~~ It'HWno and ContainarinfoflTIIJt,on) - This SlIction must bo compilitad tor 011 epphcstloM eu\}mittlld In (;oMectkm with now 

j. or lIP,,"oabW IWflOndmtmt=. 

1, Typ. of Pd~';Cm,cl; the eppropricte bloc¥ If '(f.iUr ptOOV!)f wlll bG ptH:IkaQ«i In 1M IFldlceloU p«<ka(ling typali. 

lruficate1he ailt of tho II'Id~~.tll and numbJH pu rGt.ill cOfllGincr, 

Tvra of RilWl.CMVtlller - i~tO~. of c~taifWr If! which product wJII b. morkOllttld . 

.L.\HtlltIon of ~1_~~ ~~' tho loc1l;UQTI of lhe Jiot eOllHlnla InfQflTICt\{,n for v;:>ur prtufuot. 

Sluts) of n.tNContaioot .. fV tM rat contents of 011 rf/taU conUirt4fs tor yool produot. 

5. l..otadon of ~~. ndlcllte th4 IQCation ot thll U'II dlrGetlmu: for roor product. 

6. M#nfHIf In wNfm'\A.l h afiHlfQ'-prOWc1 • tndlcated thlt !lwthmJ prwuct lab&! it llI\tachlid to rat!JII COntmrwr. 

• • •••• 
#.' 

... 

I, Cynthia L. Giles-Parker, Product Managerl Fungicide-Herbicide 

Branch, Registration Division, Office of Preventio11 1 Pesticides and 

Toxic Substances, U.S. Environmental Protection Agency. do hereby 

certify that the pesticide product listed below is currently 

registered with this Agency under the Federal Insecticide, 

Fungicide, and Rodenticide Act, as amended, that the label attached 

is a true, correct, and compared copy of the correspondence of 

record, and that the product may be sold and marketed in the United 

States of America for the uses indicated on the label. 

The product registration listed below has been issued to: 

Rhone-Poulanc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, North Carolina 27709 

EE! Registration Name of Product 

264-418 PRBP~Brand Plant Regulator for Cotton 

IN WITNESS WHEREOF I have hereunto 

set my hand and affixed the seal of 

the u. S_" ENVIRONMEn PROTECTION AGENCY 

this ~.; day of •.. A.D. 199$' 

Cynthia L. Giles-Parker 

Product Manager #22 

Fungicide-Herbicide Branch 

Registration Division (750SC) 

138 
.",. RHONE-POULENC \<~_n~/ -?-..--- '" F:? _"S=-- __ m ___ ""~_~ ______ ~_'___:_ 

RHONE.POUlENC AG COMPANY 

]anUilr}' 12, 1995 

Ms. Cynthia Cile:;~Parker 

Ofiin: o( Pt'sticide Progrnms (H7S05C) 

DO(llment Processing Desk (CERT) 

us. EnvioJIUY\entai Proi('cnon Agency 

l~oom 266A, Crystal Mal12 

192! Jefi{'u>on lJavisl-lighway 

Adington, Virginii1 22202 

iJ('ar ylr Giles-f',)rkpr: 

.... ~--------

I{e: I"R£p1'\1 br<Jlld Plant Regtlintor for Cott~)~l, EI~:~ R~·.!i' No.: 164-418 --.. --

PJca:-;e prot'idc u$)vlth three (3) certific.Hcs Df registration for the 

include Lilt' fo!Jo\{:ing inforrnntion on each certificate: 

'-

1) Rt'gistran!: -1thnlle-PlJulencAg Co.mpauy _~ __ 

p.n Box 12014, 2T. W. Alexander Drive 

Research Trjallgle l'ilrk, Nnrth CaroJinn 27709 

Please 

~) 1\:J.nl!~ oi thr~ Ptnduct: PREpl'-1 brand Plvnt RCh'1.:tlator for Cotton, EPA Reg. Nn.: 264-418 

" ... lhat the product l)Hy be sold and m<1rketed III the 

Unitl..>d States for the uses inil icaled on the lab"I." 

) 

P!,..,.I&'" c(lllt,l('t nw ilt i919) 5,19-2112 ShllUld .n)'1 h;)ve ;;r)~ .. q\ll'slions. 

. , " , //L.,L/A--; L,i·, </HddL(~ 

',,-, 

}lIdith L rv~oon) 

Rcgistratlllil ))oclJlnep t5 SP('t'i,1Ust 

0'0 e~)f ',2UQ ? rN ".I EiA:,')'P Pi' '. "" 

"[SfA"'CMTR'A'~G,tr.""1< riC ::' "l 

;;:119', SMi-1D'v'0 

INTtJlI,ATI0ML If"Lx f,UiGcn ~?)j VI' ,N/',','LI'C'.:,~I' .',1< Fl" 'l;1fR~'Af:i)Hr,i iCls-rwl' "(j>-i', C"\!' >," fF _ 'c' ;'j' In!'i,:' ~',l");' /,>j'.'/,\, Cd-!~", f,,~i (/. 

•••• 

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rXC".','~0(;:;3,'11 Pf'.'7()"7'?n, d 

139 
~ ~HONE-POULENC 

• 

RHONE.POULENC AG COMPANY 

ETH 94-20 

November 8,1994 

U. S. Environmental Protection Agency 

Office of Pesticide Program Document Processing Desk 

Room 266 A, Crystal Mall No.2 

1921 Jefferson Davis Highway 

Arlington, Virginia 22202 

Attention: Ms. Cynthia Giles-Parker 

Prod uct Manager (22) 

Fungicide Herbicide Branch 

Registration Division (H7505C) 

Dear Ms. Parker: 

RE: PREP® Brand Ethephon for use on Cotton and Tobacco 

EPA Reg. No. 264-418 

.", " ", 

Based upon your November 8,1994 acceptance we are submitting one copy' of final labeling 

for PHEP@ Brand Ethephon for use on Cotton and Tobacco. We really appreciate your fast 

approval. 

• Sincerely, 

h;': ..<, "/, 

,"/[/&:;';4,. '" //f!;~.~,~ 

Warrcn A. Davis 

Sen-ior Registration Mm)ager 

f'JB()f lX!H ') iN AUV,~.,::Cf1'.Jf1-.'~ 

I1SS~NiC1' WiA',(;L':: PMh, '1 (: :'l!:') 

,'}',<}"S4\j':-iX(l 

1"TU<'H·.110'-IA~ ;~l~X ~i'.Jli31I1·)),f'l}'D i'~;c",f.Rt.FL'-; t,'"'C >,-P 'N;fi"N1\~I:)NM ~"srr';lni ,f,O'. \fy,\,,(:F<; F, h: /,i .YU~" ~'J4~",:' LhSV}f>;[;Y'" t.pe U~ 

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• 

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• 

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L\ce;.'o'·'f~;P F'ortc-r:'Gncf'-

P,'de ,'n Ach,c,-prnen! 

140 
l 

1Z,'IT fiEVlE',tED 

If'!. !hoo't,~'?Jj(;(j v.\-c;, ~t. }t:ti0« 82-~2.1 

tl".1.0ix1 "71 Dt-tlft LataliLg [rb.tod / / _ if - '7 f 

PRE P TM BRAND ETHEPHON FOR COnON AND TOBACCO 

For Commercial Use Or Agricultural Use Only_ Not For Rasldential Use 

ACTIVE INGREDIENT: Elhephon 12·Chloroelhyl) phosphonic acid- ........................................................ 55.4% 

INERT INGREDIENTS: .......................................................................................................................... .44.6% 

'This eroduct conlains 6 !?Ounds ethephon per gallon. 

EPA Reg. No. 264-418 EPA eat. No. 264-PA-Ol 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

Si usted no entioncio Is etiquota. busquo a alguien para quo so la oxplique a usled en detalle. 

(If you do not understand the label. find oomoone to explain it to you in dotall.) 

For MEDICAL And TRANSPORTATION Emergencies ONLY Call 24 Hours A Day 1-SQO-334-7sn 

For PROPUCI l!lIll. InformatIon Call 1-800-334-9745 

The use of this product for a varioty of plant growth regulation uses aro protected by United Stales and toreign patents including 

U.S. Patents 38,791,188 and 4,240,819. No license Is grantod to use this product 10 countries other than the United States or for any 

_te not contemplatad by this label. liability for paten! inlringoment may result from use or sale of this product outside tho Unitod 

tatos. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyelids open and trush with a gentle stream 01 water for at least 15 minutos. Get medical atlontion, prelerably an 

ophthalmologist. 

IF ON SKIN: Immediately wash skin with plenty of soap and water. 

IF SWALLOWED: Do not induce vomiting, Promptly drink a large quanlfty ot milk. O9g whites, gelatin solution or if these are not 

avallable, drlnk largo quantities of water, A\IOld alcohol. Call II physician immadiat&ly. 

IF INHALED: Remove ... ictlm to fresh air. II not breathing. give artificial respiralion. Administer oxygen if nacessary. Get medical 

attention. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

COAAOSJVE. Causes ayo and skin damage. May be fatal if absorbed through skin. Harmful if swallowed or inhalod. Avoid breathing 

~y mist. Do not got in eyes, on skin or on clothIng. Koop away lrom domestic animals. 

WOTE TO PHYSICIAN 

There is no specific anlidote. Alltreatmentshouki bo basod on observed signs and symptoms of distress in the patient. Overoxposure 

to materIals other than this product may have occurrad. 

Victims 01 severe overexposure. by inhalation, should be kept under modical obsorvation for up to 72 hours lor delayed onset 01 

pulmonary edoma. In a victim 01 over·exposure by ingostkln. carelul gastric lavago Is required due to tho possibllily 01 stomach or 

esophageal perforation. This material is an acid. but use 01 alkaline substances to noutralize it is conlraindicated. 

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and other handlers must we3I coveralls over short-sleeved shirts and shor1 pants. waterprool glo ... e5. cnemlcal·resistant 

footwear plus socks, protective eyowear, chemical-rosistant headgoar for overhead exposure and chemical-resistant apron when 

cleanIng equipment or mixing and loading. : ••••• 

Discard clothing and other absorbod mate(mls that have boen dronchod or hea ... ·dy contaminatod with this prod~~ntrato. Do 

not reuse them. Follow manulacturer's Instructions for cleaning/maintainIng PPE. It no such instroctions tor washables. use detergent 

and hot water. K04P and wash PPE saparalo/yfrom other laundry. • : •• :.: 

When handlSfS use clos&d syslems, endosod cabs, or aircraft in a manner that meets tho roquirementslrsted in tho Workor Pro'&c1ion· 

Standard (WPS) lor agricultural pesticides [40 CFR 170.240 (d) (4-6)), tho handler PPE requirements may be roclUcad or mod~i\21·at! 

specifIed in the WPS. : •••• •• 

User Safety Recommendations 

Users should wash hands boloro oating, drinking, chewing gum, using tobacco or using the toilet. 

Remove clothing immediately if pesticide gols Insido. Then wash body thoroughly and pot on ciaan clothing, 

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141 

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ENVIRONMENTAL HAZARDS 

Do not apply directly to water, or to areas where surface waler is pro sent or to inlertidru areas balow [ho moan high water mark. Do not 

contaminato WaltH when disposing of equipment washwatora. 

Do not contaminate water used for irrigation or domestic purposes. 

USE PRECAUTIONS 

Do not apply PREprw bi'and Ethophon through any type of irrigation system. 

Avoid $pray drift to nearby crops tiS this product will caUSG modifications in plant growth. Plant Injury or reduood yialds will rosult. 

Do not plant anolhar crop within 30 days after rroatment. 

Mix only tho amount of spray you expect to use each day. 00 not allow mixed solution to stand overnight 

DIRECTIONS FOR USE 

It ! •• violation of Federal law to US8 this product In • RUlnn.r Inconslatont with fl. lab.llng. 

Read entlr. labe' before using this product. 

Do not apply this product in a Vitt( [hat will contact WOtXors or other persons, o~hor dlrOClly or Ihrough drift Only protected handlers 

may be In Iho aroa during appflcation. For any requiroments specific to your State or Tr'lbe, consult tho agency responsible for 

pctsticide regulations. 

this product only in accordance with itslaboUng and with the Worker Protection Standard, 40 CFR part 170. This standard contains 

for the prolection of agricultural workers on farms, forosts, nurserios, and greenhouses, and handlers 01 agricultural 

It contains requirements for training. deconlamination. notification, and emergency assislanco. ft also contains specific 

and eXC4Iptions pertaining to the statements on this labol about parsonal protoctlve equipment (PPE). nolilication to 

and restricted-entry intervals. The requirements in this box only apply to uses 01 this product that are covered by the Worker 

Protection Standard. 

00 oot entar or allow worner ontry Into treated areas durlllg the restrlctod-ontry inlerval (REI) of 48 hoUrs. 

required for early entry to treatOO areas that is permitted under the Worker Prolection Standard and Ihat involves contact 

I ~:::~~~if.~th~:a:\t, ~h:a,S~tb&on troatod such as plants, soil or water Is coveralls over short-sleeved shirt and short pants, waterprool gloves. I' footwear plus socks, protective oyowearand chemical-resistant hGadgear for overhead exposuro. 

workers of them 

STORAGE 

Do not contaminate water, food, or food by storage or disposal. 

II container Is broken or contenls have spilled. lollow aU precautions indicated above and dean up Immediatoly. Bofore cIoaning 

on full I&npth trousers, long sieovOO shirt, protoctivo gloves, and goggles or face shield. Soak up spill wi1h absorbent media 

sand, earth or other suitable malerial and dispose of waste at an approved wasto dJsposal laciflty. 

DISPOSAL 

Pesticide wastes are acutely hltlardou$. Impropor disposal of excess pasticide, spray mixtUre, or rinsate is a violation of Federal law. 

If these wastos cannot be disposed of by usa according to label insrructions, contact your State Pesticide or Environmental C~,"I""tf 

Agency or the Hazardous Waste represenlative at the nearest EPA Regional Office for guidance. 

CONTAINER DISPOSAL 

Triple rins8 (or equivalent) the empty containers. Then offer lor recycling or reconditioning, or punctum and dispose 01 in a sanitary 

landlill, or by incineration or if allowed by state and local authorities. by burning. II container is burned, stay out of smoke. 

RETURNABLE ~- REFILLABLE CONTAINERS 

GENERAL INFORMATION • •• .' . •••• 

•• 

• •••• • COTTON ••••• 

A foliar spray of PREPn.. brand Ethephon wiU accelerate opening of malure unopened cotton bolls and enhanco dffo/raT~n which can 

result In oatUar harvest with an increased recoverable yiold. PREpm brand Ethephon treatment on cotton allows increased efficiency 

lrom a once-OVer harvest. : ••• •••• 

142 
TOBACCO (FLUe-CURED): A loliar spray of PREPTlI brand Ethophon promotes oarly, uniform "yellowing- 01 mature tobacco. 

PREP"" roduco! curing Umo, allowIng more offlCiont use of ctJdng barn spaco, and incroasod control ovor harvost schedulos. 

SPRAY PREPARATION 

Add 112 10 314 of tho required amount of water to tho spray tank. Start agitation. Add the raquired amount 01 PREP1')ol brand Ethophon, 

and tho remaInIng amount of water. Prepar~ only as much spray solutton as can be usGd on the day of mixing. 00 nol allow spray 

solution to $land ovemight. Do not spill the conconlratod product on spray equipment. or any altplano parts. 

ANY SPILlS SHOULD BE RINSED IMMEDIATELY WITH PLENTY OF WATER 

Use 01 a nurse tank is highly rocommondod lor avoIding posslblo spitts 01 coneontratod lormulation on spray equipment or any airplano 

paris. 

TANK MIXTURES WITH DEFOLIANTS AND INSECTICIDES 

PREPTM brand Ethephon is compatibfe w~h DEF1, FOLEX., Droppl, Harvade3• Mathyl Parathion, Guthionl , and Matathion4• PAEp'N 

may be applied In sequonce or as a lank mixture {DO NOT TANK MIX WITH DEStCCANTS IF COTTON IS TO BE SPINDLE 

HARVESTED}, Follow all applicable uso procaotklns and rato por acro recommendations on labols 01 products applied as lank mixtures 

or In sequonce with PREP 1M brand Ethephon. In samo cases slight reduction in boll opening rosponse has boen observed when tank 

mixos with dolotlants were used. 

Good agitation in tho spray tank is essential and a tank mixture should not bo allowed to stand without agitation tor moro than 5 to 10 

minot.s. Read and observo aJJ appropriate Iabol use directions and procautions for tho defoliants and insocticid&S usod. 

NOT E: UndGf certain conditions, tank mixtures 01 PREpn.! brand Ethephon with desiccants containIng sodium chlorate could 

rosuk in Ihe lormation of hypochlorous acids whk:h on hoating witt omit toxic chlortde lumes. 

EQUIPMENT CLEANING 

•

causa 01 tho acidic naluro 01 this product, prolonged oxposuro to spray doposit witt damago acrylic plastics. cortain paints. and 

otals. 

Rinse thoroughly with a detorgont and water all exposod acrylic plastic-typo materials (e.g .• aircraft wlndshilllds). and painled surfaces 

wlthln an hour attor expo$uro to spray doposits. 

At 1he ond of ollCh day, rloso thoroughly with a dotorgent and wator all the motal parts of tho aircraft and the associated spray 

oquipment exposed to tho spray deposits. 

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143 

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COTTON 

EXPECTED PREP'fId ONE SPRAY VOLUME APPLICATION 

USE CONDITtONS RATE GALLON (Gala/A) TIMING 

Plnl./A I LBS A.!. Ac< •• AIr·· 

PREprw Hot and dry 8O&J= or I 113 1.0 6 Apply whon the ~.~; 

Boll Openor· higher maturo ,_~Us., 

Dry and 75 to sooF 2 1.5 4 15 -50 2·5 I 10 I!'. , . 

Cool but above 65~F 22/3 2.0 3 I •• t 01. 'bo, I 

Treatment ";~~rr:r~ns 0' bolls 710 14 days in. ~", 

PREFN + High soil moistUre tl3 0.25 2' 15-SO 5-10 I ~~p_~_to 7 days prior to FOLEX· 0' boll opening 

O.tollant Tank High fertility lovol To be used as 

MIx ~ot ~ pl~.?, with. 0, boll 

Rank ootton 

Oropp2 High soil moisturo 1/3 0.25 2' 10 ·50 3- 10 Apply 4 to 7 days prior to 

OofoHant Tank High 1ertility Iovel PREpn.! boll oponlng 

Mix Rank cotton 

application. To be uSed as 

a S~~;~lrGatmenl with, nolln of PREpm boll 

Pr.·CondIUoner Hot, dry, 2/3 O.S 12 Appry 4 to 7 days prior to 

for Defoliation Cool, above 65~F I 1/3 1.0 6 15-SO 2·5 defolianl. Enhancos, !oP 

0, crop dotoliallon 

datorioration 01 bottom c~ Rank cotton and alloWS tor II 

·Pretreatment WHh DefollanfS Prior to PREpTM Boll Opening Treatment 

If the cotton 15 overly rank or laying down in the mlddl •• and good spray coverage ot tho bolls with PREpI'M is difficult, a pretreatment 

wilh defoliants will be usofullC improve boll coverago with PREpnc. Use dosage rates of PREPni brand Ethepilon recommended fOf bon 

openlng. Road and observe an appropriate label use dlroclions and precautions for the defoliant used. 

"In California and Arizona use a volume of no tass than 5 gallons per aero for aerial applications. 

!!aIofl Maturity 

"'boU is mature when ~ is 100 hard to be dented when SQuGezed between thumb and lingers, too hard to be sliced with a sharp knife, and 

whon tho sood coat becomes light brown in color. 

Use Limitations 

Do not exceed a maximum of 2.0 lb. aYA tor combinad uses at PREpnt pGracre per year. 

Boll Opening: 00 not tank mix PREpm brand Elhephon with a desiccant if the cotton is to be spindle harvested. 

Pre.condltion for Detollation: Do not tank mix PREpn.! with desIccants unless plant desiccation is required. Do not use a detollant 

before there is sufticienl mature unopened bolls to produco tile desired yiotd {soe Generat Intormation saction on how to test for bot! 

maturity. 

WHEN TO HARVEST COTTON • • •••••• 

• 00 not harvast cotton soonor than 7 days after a treatmont with PREpnt brand Ethephon. • _ 

absOlVe the treated crop and harvest when optimum boll oponing has boon roached. Too early harvest might reduC& iliO full advantage 

of tho treatmenl and too late a harvest may result in reduced quality and loss at Um which will drop ttom the plant. • : •• :.: 

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144 

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PREPnI 

Crop Situation Plnta/Aer. 

Oirocted Spray t t/3 

Application 

OVer-Tho.Top 11/3-2213 

Application 

USE LIMITATIONS 

Ac," 

50·50 

fOBAeeo 

(Flue-Cured Only) 

Spocfffc Dlrecltons 

I with 20% ; . 

Treat only WhEIn leaves remainIng on the stalk are mature. To ensure 

remaining leaves are mature, tost spray several tobacco Plan~ ... ~~ 

doscribed under the section "Proper Time of Treatment.· Use the lower '~' ... 

In a normally mature crop whon experience indicates that m'lnimum i 

inducement is required. Use the higher rate when the crop is heavy and has 

a tendency to be more rank or when temperatures are lower than normal. 

Always test spray to detorminG if the tobacco Is mature enough to respond 

to treatmont with PREp-!'!oI brand Ethephoo. 

Apply over·the-top PAEprw brand Ethephon spray as a tine mist using three 

nozzles (one nozzle tips over the center ottho plant, and one o~ ~~~_'~~d~ so all loaves are covered I slmilar to tho I pamml oi 

osudw <oWol oo.nl$. li,.. • of 40 10 50 cal 

00 not apply PAEpPt brand Ethephon to immature leaves as thts can resuK tn unsatislaClory coloring, weight loss and reduced leal 

quality. 

00 not aUow the crop to over ripon in the lield alter using PREPN brand Ethophon. since this may cause some reduction in yield and 

qUality. 

00 not treat beforo anticipated major storm which could provent halVost and result in crop toss. 

00 not apply PREPN brand Ethophon if rain is expected within 4- hours. 

APPLICATION TIMING 

$uccossful results with PREpn.c call tor trGatment when leaves ar!) maturo, not overly rank green whon sprayed. To easily determine 

the proper treatment timIng and the number of toaves per stalk raady for harvest, tost spray sGVerat plants In more than one location in 

aach flold and obsoMil1hG response. Mature !tavos will begin to yellow in 24 to 72 hours. Test loaves that fail to yellow In 72l,lours are 

not malure and are not ready for PREpn! brand Ethephon treatment. Wait a few days to pormij lurther naturat maturing, then make 

another teS1 spray or -maturity· check. 

CURING PREp1l' TREATED TOBACCO : ••• :. 

Curing ptOCGdures aro as much an art as a scienC6 alld each cure must b& ludgod on the basis 01 tobacco conditlbn, rnterval betWo&n 

treatment and harvest, weather and typo 01 curing lacility belore prescription temperature and ventilation scPledules c:!n"" 

establishod. To obtain maxImum quality, care must be taken to obsolVe and control the curing process closely, especially during thi!' 

tate -coloring- and early *drytng" stages 01 1he lea/. •••••• • • 

PAEpnt brand Ethephon treated tobacco will havo startOO the coloring process when harvested, reducing Ihe time "~'" in the •• 

coloring phase of curing. Tr08t&<:l tobacco should be driod taster. H tobacco leaves are groon or contain some greel'fwtfbn harv'Ct)tI~ • 

it may be necessary to color them lor a lew hours. If the leavos are completely yellow, temperature and ventilation mull be adjumM'" 

a manner to dry the tobacco as fas1 as possible wHhout scalding, Onco the leaf is dried (314 dry), you should tollo~rfm\I procedures 

tor curing. Since PREP!")!: brand Ethephon treated leaves cure faster, treated and un1reatod leaves should not be cUJIQiOolocgether in the 

same bam. • ••• 

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145 
LIMITED WARRANTY AND DISCLAIMER 

The manufacluror warrants (a) that Ihls product oonforms 10 tho chomical doscripUon on tho Jabol; (b) that this product is reasonably lit 

lor tho purposes Ht forth in the diroctions for us. when It Is used in accordance with such directions: and (e) thallho directions, 

warning and olhor statements on this labol are based upon responsible experts' evaluation of reasonable losts of oftoctivenO$$, 01 

toxicity to laboratory animals and to plants, and of residuas on lcod crops and upon reports of field experience. Tests have not boon 

made on all varktlios or In all states or under all conditions, lHE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES rr 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES. EXPRESS OR IMPLIED, ANO IT 

EXPAESSl Y EXClUDES AND DISCLAIMS ALlIMPUED WARRANTIES OF MERCHANT·ABILITY OR ATNESS FOR A PARTICUlAR 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO. AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THtS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S eXCLUSIVE AEMEDY AND MANUFACTURER'S OR SEUER'S ExcLUSIVE UABIUTY FOR ANY AND ALL CLAtMS, 

LOSSES. DAMAGES. OR INJURIES RESULTING FROM THE USE OR HANDUNG OFTHlS PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT, NEGLIGENCE. STRICT UABIU1Y IN TORTOR OTHERWISE SHAlL BE UMITED. ATTHE MANUFACTURER'S OPTION, 

10 REPlACEMENT OF. ORlHE REPAYMENT OF lHE PURCHASE PRICE FOR. lHE OUANTITY OF PRODUCT WI1H RESPECT 10 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAl, INDIRECT OR 

CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. 

NOTICE TO BUYER 

Purchase of this product does nol confer any right$. under patients governing this product or the use theroof in countries outsido of the 

United Statas . 

• 'DEF and Guthron ara registered traoomarkt ot Bayer AG, Germany. 

2Dropp is a registered trademark of NOR·AM Chomlcat Company. 

3HaNade is a rogistared trademark 01 Uniroyal Company. 

"Malathioo is a tradomark of Amarican Cyanamid Company. 

RhOno·Pouktnc ArJ Company 

P.O, Box 12014, 2 T.W. Alexander Driva 

Research Triangle Park. North Carolina 27709 

PREP is the trademark 01 RhOno·PoulQnc. 

FOLEX is a registered trademark of RhOno-Poulonc, 

PREPn.o brand Ethophon tor Colton and Tobaceo (MASTER) Approvoo 1tl3l94. 

• • •••••• • 

• • •••••• • 

• • ••••• • •• • • 

· •• .. • ••• • 

• 

· ., .. . •••• 

•••• • • ••• 

146 

•••••• • .. • 

••••• • • ••••• 
• 

• 

Mr. Warren A. Davis 

Rhone-Poulenc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, Ne 27709 

Dear Mr. Davis: 

Subject: Revised Tobacco Directions 

PREP Ethephon Cotton Boll Opener 

EPA Registration No, 264-418 

Your Submission Dated October 24, 1994 

The amendment referred to above, submitted in connection with 

registration under the Federal Insecticide, Fungicide and 

Rodenticide Act (FIFRA), as amended is acceptable provided that you 

submit one (1) copy of your final printed labeling before you 

release the product for shipment. 

A stamped copy of the labeling is enclosed for your records. 

Enclosure 

Sincerely yours, 

Cynthia Giles-Parker 

product Manager (22) 

Fungicide Herbicide Branch 

Registration Division (7S05C) 

147 
, 

• 

• 

- --- '---~-~-- ---------------

FEll 

SIG (DATA) 

FEll 

PI! 

!!ITH PATA 

FEll 

SIG ,(CATA) 

PI! 

c9f"1"-# ~J?7 j:6 

/t'P7/f7</ ;.. 

I Fi, fl<i-v{l 300 

5 17& Jb'Z"7 

1M': '1'UCX- • 

»'LlCA':IOII lOll ~ : 

Init. Data 

lI!GllUJI 

110 PATA 

,FEll 

PI! 

, APPLICA':IOll lOll AllElIDlI%lIT 

Init. Date 

FEll 

PI! 

Init. Oat. 

~/M/ 

Init. ,Data 

--

'. -

• Front I:nc!. Processing ,dat.n.inecS thi_, application' -qualU.i__ ~or nilt uac1c ravi.." NHct ~n Z'lI9iauanta 

clailll of ..... _.. 110 _=-aan for: _w..1:antial,.ilIIlla:rity1_ lI&~io by tha 7ront' 'ZIIcS. 

148 
. ZRPNT IHR 2R~!BIXHa~2fM~aTIOH tHlPSHATIOH CBZC~ 

PH' e 

ZPA COHPJUn' inman.,d ?pi 

ZPA IIIciI~'1'RJ\'1'IOH trr1K1I~f- (It' 

nuo.s (1"0t' "'eIl4lteIlte,· . Active ~ . - . 

, Hot in REFS __ 

Active -.:."':' Caricelled __ 

• Hot in REFS 

PAAT.Rl:CORD CRZA'1'ZO 

; 

, ,. 

1 . 

• I 

i I , . 

149 
• 

• 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

W-¥ll9':l'1JQI,j. D.C. 20<60 

WARREN A. DAVIS 

nIlONE-POULENC AG COMPANY 

P.O. BOX 12014 

RESEARCH TRIANGLE PARK He 27709 orner-OJ" 

J'IlFV(tnlOtl, N;STICII)(S}'NO 

roxlCsUBsrmcrs 

PRODUCT NAME: PREP BRAND ETHEPHON FOR COTTON & TOBACCO 

COMPANY NAME: RHONE-POULENC AG COMPANY 

OPP IDENTIFICATION NUMBER: 217786 

EPA REGISTRATION NUMBER: 264-418 

EPA RECEIPT DATE: 10/26/94 

SUBJECT: RECEIPT OF AMENDMENT 

DEAR REGISTRANT: 

The Office of Pesticide Programs has received your application 

for an amendment and it has passed an administrative screen for 

completeness. 

During the initial screen we determined that the application 

qualifies for fast track review. The package will now be forwarded 

to the Product Manager for review to determine its acceptability. 

If you have any questions, please contact C. Giles-Parker, 

Product Manager 22, at (703)-305-5540~ 

sincerely, 

. /. L:;,.a:.,J 

Front Eh~ ;rocessing Staff -cJ'~~Information Services Branch 

Program Management and Support Division 
Ph $11 rd'la t • 

&EPA 

United S1111;tS 

Environmental Protoction Agency 

W3!1'hlngton, DC 2.0400 

~'I Registration IXX Amendment 

Other 

Application for Pesticide ~ Section I 

OI'P Identifier Numbu 

217186 

1 Compllny!product Number l2. EPA Product MllmlQllr 13. Proposed Closliifh::artlon 

-4.-C-()~lP"-'-YI-P,-"'-"~e~~(-N-""'-) _264-418 ._- .TO.b .. ~-£-c_o-... -~-_I.; ?_M' C, .. ::1 es-Pa rke~r ___ .1 ~ ",,' 0 R"tri"", 

PREP br.and Ethephon fo,_Cotton & _ .... _ ....... _ . .. 

5. Nome liM Addrosft ot Apptictlrlt 'lnc/udo ZiP Code} Rhone-Poulenc Ag Company 16< Expedited Reveiw. In accordance with RFRA SeClion 3(c)(3) 

I (hHi). my product is similar or identical in composition and labell'ng P.O. Box 12014 

2 TW Alexander Drive 

Research Triangle Park, NC 27709 o ChltCk if this is a mtw ifddrtlss 

! to: ! EPA Reo. No. ___ . ___ •.. __ . ___ . __ 

! Product Name 

Section· II 

Amendmenl· Exploin below. Final printed tllbd. in repsonllo 10 

Agency hl\tor dat1id -.-.--------_ I 

"Me Too~ Application. 

0lhn· Explain bmow. 

-_ ...... ------_.- E)(~anation; UBf,I {I(jdftlonru pll{IelBI if n<lO(l$Bl'lry. IFor section land S.c\ion 11.1 

Improvement in timing for harvest of treated tobacco. 

Recommendation to harvest all yellow leaves before treatment. 

Section . III 

Section· IV 

.-~.-

• • 

t, COn1rI~~tm:~t fComplf):'~ lrflm!F direclly btlow fer fdM(iffc4tkm of inrJiyJ~~sl ro be con~cttxf, if (ulce5!iJ.fY. to pmc/W WI: ~tt:,) 

Name TIll" Tolophono NtP.f{lt\tludo ArCH) Code} 

Warren A. Davis Senior Registration Manager 919-549-2i79 •••••• 

• • • .. _'--- ..... ~~ --~. -----"--- .. . - . . ~. ! e: D~bApPlioa._ ••• 

1 a..4IIvcd •••• 

• •• 

Certification 

I (;ortffy lhat lhcllllJtomonllll hove made on lhis torm and ollattpchmonlt; thOl0to ate true, aceUlale and c9fTlP!lIle, 

I ocknowtlKfoe thai any knowlinglly talM or mii!l!&3dlna $lllt&rMnt may be pI.mi$hOOle by tine or imprisonment or 

both Undol spp!icebltlillw. 

•• lS1amJHM>:" • 

• ••••• 

'~~ j/J~-.. -u-.. ~-_. __ ··_- . ... 13s;~;or R:9~-s~t-r-a-t-io-n-~-ta-n~a~g-e_-r __ ~~ __ .-_~._-_-_ 

4. Typod Nrun-u 5. Dalo 

WarrenA.Davis I/O!;;"'I/'1'/ I 

. ·, .. . •••• 

..... - • . -.. 

1 c:: 1 

Whit •• EPA FlIto Copy {orlglnall Yellow. Apt)/ieant Copy 
-------

~ ~n2M ACT IQI!CE: fth{le ~tf~ ~ fur thb. COHbCtiQ) of InfO(i!il!l!tttn it -%timtw 

t-tl ~ $.U5 fwur !WI" r~, imtodif$ -rfu jeff rwltt4if'CII {m;trutt'iitM", ~h'!G udnil"El dliIJu 000n:;1.I$, ~lrlS W'ri 

mtl>lf1tainlt'lG the oo!a ~, :Md c;'lWpleHng ~ l'lrJiewt;w iJw, l:e11'bCtan fit fnfqn\!&thm. $md ~tiS r~-<!lne tM ~ 

esthziiJlte or Uff otfwr ~t of thb cnttection Of ir;f0!fft«th;rtt~ !ttttltH~ ~t1(lnji for r«tx:ina this butd$), tc Chid, 

It'!fen!l!iition I'olicy al'1'!hC::h, ffi-223", u.S. auf~l PNt.cctim ~~ 4$1 K SttiW:t~ W, ~in$Tcn. DC 2.fi4OG; >'n1 to the 

Offlcwof Inf(}N1t!ltion I!fld I!eaututory Affltitt!. OfHu ,/{If lila G It and, ~~ Irlwrhlngtan. DC 2C'ro3. 

IHsnwtTlfmS: This 10m \s to be tilled fer all iwlicctitmlS for,.., t1!gfstratim. end we rei"¢\listftltlon, ~t. 

rd1Jl;:aiacion. to applicatlMII- for Mtifictlticm., finellX'intM tl)lbdfJ!!&" nn'lQlf>trJltfon, !ltc. In Ct'W te pf"¢CaM: un epplleatfen 'for III MY r-egistratjon stAaritted en this foms,. ,lM- i'oltll!!lrinu _tertal lI'Ult ~ tfwt applicadon: 

1. Certification with Resp«t to Cft.at:foo ot ~ (@'A f«m 1i57&-29). IIf I'I6t ueapt:ed by 40 ern 152.81 (b) (4)1; 

2. Confidential Stat~t (of f«YSJta (EPA FtA"1It ~); 

3. For.datar': E>;~t(lfl StatC'lCCnt (fAA roni ~mf 

4. five: ceplu of draft taUns; " 

5. ThNte copi_ of MIY dilttl eWarlitted; 

6. 1.Utbor1utiOfl letter ~ flJJPtietilbI~; 

7. Matrlee. whltr. I!ppHubte. 

St.tmis,fen (If lilbeHng • l&beling dtatlld Ii,..t be cubratttcd 1ft tOO fr.!nI of <tnft l&betl< vith aU .swUutions fo: mN 

l~L 

reglstratton. 

If prepared 

Such draH 1m. Jll!)Ck~, hobels: IIDY 

it -sbwtd 

be in 

bt 

tM 

censtrueted 

fom of typIid: 

in$lldt. 

t ..... wet 

VIZIf{ 11:$ 

on a.5 

'to f;scHitau 

j[ 11 incll 

stCN4C 

pape1' or 

in 

a IIIDcltt.p 

lin 6.S x 

of 

11 

the 

inGh 

~ 

Htf:. H"k~ t&beIs sfsnifjuntly MIItter thM 8.5 x 11 il1l:be$ :iiMtJtd be ~ (In 1L5 ;1. 11 ltd pilpIIiW tfX' ~iS&ion. 

Silblriu:icn of»at. - Data w/;::$Ittw in ~ of this: appliarthn IIUIit b1!! ~tt«f in ~ with PR Mott" &6-5. 

SPECIfIC INSIRl!C1IQMS: P"lecae r. the Jmtl'Wd(lf$ Hstl!d .beICIIW M#l)t'# COiIilPt¢dtlll this appliutloo. first 

detetmiM the t)?e of regJstntfeo bCtioo, Hsted il'f Jltod A~ flM" liftldi you lite tdlaittine this ~iution. fer 

eppllcatl()f'j$ etbIltttd In c«:Y'r«"tlon wltb Nw IqIlnratI(Ift aetiOll$~ SKt;i_ l~ tfl, lind IV _t be ooaptctrti U; the 

~1ICN1t. for appUcatforlS m!lsiitted in cat'll'"le(;tien 'Hit .. ~ rqi;,t:ratIen llltti«», ~!$5lorw. MtHiutiOl"d-, • f'CregistntiCflll-, etc., S!!(;tlOflS I, II, IiIf'ld IV IIIWt be ~eud: by tlw iIljiptiomt. 

DIad: It • ChtM:k til. appropriate ectlOfl fer ~idf ye'U IlIh'! ~ttfns this (WL 

SECTIOH l - 11li$ srn::tioo wet be «:!IIiplH~, '" ~ieab!lt~ IM".U ro:eh:tNltiao httj(!I(;B. 

1. ~/Pr.:du:c"t ~1' - l!lMrt your ~~ .. rt mw _ b@m _i£llWd by EPA. tblz ~ 1!;1$'f !1IiVt ~ M$l~ 

to YtIU 00 a basic r~i:lltrMlt~ a dhifriwtW. or • m __ u.bii~. If yooT ~t it reufUerM, i(>£ut tnll' 1¥6dut-t 

2. EPA -. ~ ~ - H Icno!m, tilt in tOO rnliI1iW ad 1m ~ ri tite EW\ ~t ~. 

3. J'>~ CI_HiI;&ti«'! - SpteJfy the ~ d¢>il:ifk,.,H_ &f mis ~_ 

4. P'~t: ~ - Entn the cwvlete pr~t: MWIt af tM$ poootidrle <$ it yiH ~ en t:1w l~l. flw ~ $Mit be 

epKl1le to thh- ~t mty. !:b~tfc.th;n of ~ is rort pMIDrtMl ~ pr0tizts 01 the $!\!!Ile~. tn'Mt intli.rle 

IXf/ brand ~ Gr' c~ tirw 6es}unstfO!'!:$. 

S. !kr!mtt 1I!II1d~ GfApp{f«mt - Tnt t'lGImt tJf tM Hrw:tIW~W1d ~~ in ~ twHc.atiOl'l is {htr~" &r 111'";% 

ttl ~ the rtrgfttnt!m ulB be h;~:t 1f)'\::U $fit &t;iNl fit tdta:tf /Sf ~ pt#t}i. )to !LI$t ~it wtfwdnitiOf! +rca 

Ihnt" perty ta u:t fa tllm !n regfstratfon IWIttl}($. Nt .f.owrt i!:'IWt ~idi(lijii in tim United Statre 1Iitmt h~ l!O 

~ 

IHJt[}&:l%ed 1'!Sfflt resiJlro in tlw Wited $tnh% 19- &"1: fw t%¢m in $H rt!Iqht0ttiw at~" 'EM:.- *''!6 C~de _Hlns 

Qf weh 00 &gmt moot IK£~ this, ~J~tt~ 

6. ~hlbct kvlw • r1rVA MttiM:1 {cJ 3 til:} p4t'NiiM fw ~t&i Fft"t,fuf cl' ~Ucat!(fWl f« tegiiaratioo, or ~t£ 

to exlatlr.g f%gistrfltiws, tfltlt ~ i1-1!ll1it& or i&enttlml !;{} ~ pmtid. ~tt: tMt: ~ a.wTently r-egi$t~ uHh 

the f?A. In crdtr fc(" yew' ~h~!i:tien to be eH§ihl~ W ~ted NYlriI, )QM $!L$t fJiXNf(k \.l$ uHn the .\:01. Registtetioo 

U~ and pcO!btt ~ (If Hie prd.<tt ~ !:ttJ i.we i. dsHu w <w f~fl!4l W)'W!l" ~t:. The pt'oGutt tlMtt !x • lr::lmit:.r or !cftt;tlc&t in both ftwWtwden and ruta:!: UlIW$. 

~!OM n -In\$ eutl«; _t be o:i!lp\et!iid 1« Btl ~it:cl:l:_ ~ttGd tee ~ the ng'htNiticn ooly {If it" ClXnmUy 

r4gj$tsrM Fc:AJet {~tJ, 1« .. r-..tminioo ill ~ b m# ~ tlft'Nr, r&: fWtificatl(t"l$ to tM~. f& t'lw 

lH.rbl!'Jlulen of flret prlntoo t.Una. fer f'Wd9lstnitfoo am{ fer I!nf ~ ktinn that putair::: to 8 '§tW£ifit' W-!"o?S!Hfrzi ~. This &eetion 11t!12! SQ b! U!md f'f.)f' J1I _ .&pptfcaticn fw f'll$h:t:N:Itiliil'Lt. SUbjeet of ~"ion - t:iw;1!; the tlppHcabte bled: l!rld ~da ~ ~ teater date if ~lwt~~ Provi!.%!It bdtf 

&Jq>t1.lMtien of the ~(s) 1« th¢ ~#fl'llf'jy ~ _ "'tM 1!Idlfit.ien 4f it site, pmt oc Ul:lp (specify}"; .~ tM 

CenfidMtiat St.!lt«eW'lt of fMllbt. W ••• "; "f't'ri'UIistratiQll ~uhm"; ~ hibd nl"riitien of U!W dfr«t{!WS." Att«h 

I!i sepilMItft p;see if itlddftlom;l ~ h~~" 

• • 

UCIll!iI fU"cl>ackulng ol!!! Iril!lUI!Il!r Inf<mll!l;i!ll!)· "' •• _100 "'" ... ~""" 1M oil """<at'~ subllrltted in t~tfcn \lith MU \"'q:l$tf'llitlon or e{:ptJCf'lbte: ... I >U;~ 

1. Tp of ~1'If - Cheek too ~iat. bt«i: if \"1M' ~ trill tie pdt'llfed in the irdleatw p$d:ll$ing t:ypb$ • 

..... J~icate tbt slu of t~ irdlvlu.I packets lind ~ pat' Nt$it C!lt\tAtntr_ 

·3. 

002 •• 

tJatiClur't 

~ of ~tl 

tM\;~ 

~iMf" 

-

-

Specify 

Indicate: 

the 

twc 

bet 

¢f 

~«'IU 

ocnt.lner 

of 

tn 

aU 

tafclt 

f'WrIj( 

~ 

~jftllln 

trill be 

fof' 

~ 

your product_ 

...... r=.) of"'Aeta1t ~fhDf" - SpKify Uw nK ~ of aU reteil @!IIIlIbdflllm}. fof' ya.r ~t. -s... . len of..,. tHruticro - !hdia.tft tbe toceticn of the toe' diJ:1l¢tf_ fa- yoar ~_ 

4. .......... u:~WI·h4I4t i. aUimd tl$ ~ ~ Indicate die tmd!od ~ t~ fe ~ to net.1t cootaiMf<. 

• • UtIi. n: :,Gtwtact Point) - Thi. $edion .... t be: l!GIiPleted w ott "ialtiCfi$. for Registnnion &etlen&. i .e:., 

new pt'Cduet.·~ftrl)tien, r..w.f21slon, ""1Ic-too~. f"lWq1iatrwti-. etJt. 

1·5. S.lf.~rwtory. 

6. £PA lIM MG-• 

•••• 

152 
(Y 

~ RHON"E-POULENC ::: :r: 

RHONE-POUlENC AG COMPANY 

ETH94-17 

October 24, 1994 

U S, Environmental Protection Agency 

Office of Pesticide Program Document Processing Desk 

Room 266 A, Crystal Mall No.2 

1921 Jefferson Davis Highway 

Arlington, Virginia 22202 

Attention: Ms. Cynthia Giles-Parker 

Product Manager (22) 

Fungicide Herbicide Branch e Registration Division (H7505C) 

OeM Ms. Pnrker: 

RE: PREP@ Brand Ethephon for use on Cotton and Tobacco 

EPA Reg. No. 264-418 

This submission contains ,,111 amended label for PREP® Brand Ethephon that include a 

modification of the wording for lIse on tobacco to emphasize the need to harvest any leaves 

that have started to yellow before the application of ethephon. If leaves begin to yellow 

naturally and arc then treated 'with ethephon over maturity may result. In addition we 

have made the label easier to read identifying when to use high rates and when to use 

lower rates. vVe recommend the t!se of the higher rate only when temperatures are cool 

(65F or less). In all other cases the low(>r rate should be used. A 48 hour harvest interval is 

recommended to be consistent with the worker protection reentry inten'a1. 

Based upon our conversation on October 24,1994 there should be no need for an offer to 

pay data compensation for thh::i submission as no new data are necessary and no new uses 

are being proposed. The amended paragraph relating to the usc on tobacco has been 

darkened in the label copy submitted to facilitate your review. 

• • •••••• 

• 

\-Ye \'vould appreciate your prompt attention to this label amendment to allow P!~jlt~g of 

labels for the 1995 use season. Thanks for your help. • ••• 

Sincerely, 

// / ,I· I . t.//Q:<.u," 1;. /vfu",,~ 

Warren A Davis 

Senior gcgistration Manager 

"0 R(,X '~'01~ J! ,',' M!oNV,:;~ flU!· '."-

,'JCSEARCHTR'ANCIFPAfI!c I,C :;;'II 

','1",j', :'!'f'2'"J.lC 

n<TERh:;\TICliA(. !~.P: k;"jS~11 ,18'1-3);'; f<'U,',L :{i'lA(>, t"'G ~"f' 

'I,'[t;fd;:-IONAL ::is'!'i;!'i, l'~lI" 'x-rf: n_~; ~,:, ;-~ t,,- v(,!.:(; .110)],.' i""''';LH.':"~-'_ A~<: I.:;; 

• • ••••• .. . •• • · .. •••• 

• ... •• 

• 

. ·, .. . •••• 

•••• 

• 

• • • • • 

• ••••• 

• • .. • •••• 

• • ••••• 

r xceUi',~t~ ~n f'(:.1{)!mancu 

153 
.. -.------~" 

-

BRAND ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Elhephon (2·Chloroelhyl) phosphonic acid' ............ " ...... H ................... , , •• 55.4% 

INERT INGREDIENTS, .... ...................................... .... ....... .............. . ................................. 44.6% 

'This product contains 6 poundS elhephon per gallon. 

EPA Reg. No. 264-418 EPA Est. No. 264·PA-01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

51 ustoo no &ntiondola 0l!qOOt3. busquQ a alguien para quo sa la axpliquQ a ustGd on dotallo. 

(11 you do not undorstand 1ho labol, lind SlJmoono to oxplain it to you in datail.) 

For MEDICAL And TRANSPORTATION Emergencies ONLY call 24 Hours A Day 1-800-334-7577 

For I 1-80().334-9745 

Tjru~'~.~:[j~~[':~~~fit'! U$O$ i U.S. Patan!s is granted to use 1his product in countries olhor than 1he or lor any 

uso not conlomplatod by this liability for pal on! inlringemant may result lrom use Or sale 01 this produCl outside Ihe United 

Slates . 

• STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyelids open and Ilush with a genlle stream 01 water lor at leasl 15 minutes. Gel modlcal atfention, prolerably an 

ophthalmologisl. 

IF ON SKIN: Immediately wash skin with phlnty of soap and water. 

IF SWALLOWED: Do not indlJCo vomiting. Promptly drink a largo quanllty 01 milk. egg whftes, golalfn solution or if thoso are not 

available. drink largo quantities 01 wator. Avoid alcohol. Call a physician immediately. 

IF INHALED: Remove victim to fresh air. 11 not breathing, give artindal respiration. Adminisler oxygen il nocossary. Get mooical 

al1onllon. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. Causos eye and skin damage. May be fatal if absorbed through skin. Harmfut if swallowed or inhaled. Avoid breathing 

spray mist Do oot get in eyes. on skin or on clolhing. Keep away Irom domestic animals. 

NOTE TO PHYSICIAN . 

_nero is no s~ijic antidote. Alilrealmant should be basod on observed signs and symploms 01 distress in Ihe patienl. Overexposure 

~o matorials othor than this product may have occurred. 

Victims 01 severe ovoro>:posure, by inhalation, should be kept under modical obsorvation for up to 72 houts lor dalayod OO$ot of 

pulmonary edoma. In a victim of ovor-exposuro by ingestion. careful gastric lavago is required duo to the possibility 01 stomach or 

osophageal perforation. This matorial is an add, but use 01 alkaline substances to neutralize It is contraindicated. 

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and other handlers musl wear coveralls over shott-sleeved shirts and short pants, waterprool glovos, chemical-rosistant 

lootwear pIuS socks, protllCtivo eyewoar, chomical-rli$istanl headgear lor overhead o>:posure and chemicat.~'gt apron whon 

cleaning equipment or mixing and loading. • 

Discard clothing and other absorbod malerials that have bGon drenched or heavily contaminalod with Ihis prod.cts·Concentrate. Do 

nol rouse thom. Follow manulaclurer's lnslructions for cleaning/mainlaining PPE. II no such inSlructions lor washa:t)ltts, use delerionl 

and hot water. Koep and wash PPE soparalely lrom other laundry. • : •••• : 

••• • • When handlers use closed systems, enclosed cabs, or aircraft in a manner thaI meets the requiremenls listed in 111tr\('1~ker Prplftt1tPll 

Siandard (WPS) lor agricultural peslicida! [40 CFR 170.240 (d) (4-6)J, Iho handler PPE rGquiremenls may be rod!lff2 or mOOdlita at; 

specillod in tho WPS. • •• •• ••• ••••• 

User Safety Recommendations 

Usors should wash hands belore oating, drinking, chawing gum, using tobacco or using Ihe loil91. 

Remove clolhing immodialely if pesticide gols insido. Then wash body lhoroughly and pul on clean clolhing. 

... 

•• • •••• 

•••• 

• 

154 

• • 
-------- ._-----

ENVIRONMENTAL HAZARDS 

00 not apply diroctfy to walnr, or to areas whore surfaco water 1$ prosont or to intonidal aroas below the mean high wator mark. Do no1 

contaminato water whon distxlsing of oquipment washwators. 

00 not contaminato water used tor irrigation or domosl!c purposos, 

USE PRECAUTIONS 

00 not apply PREP'" brand Ethophon through any tyJX!' of irrigation systom. 

Avoid spray drift to nearby crops as this product will cause modilicatlOns in plant growth, Plant intury or reduced yields will result. 

Do not plant another crop Within 30 days afUH troatmGrlt 

Mix only the amount of spray you expSCI to use each day_ Do not allow mixed solution to stand ovornight. 

DIRECTIONS FOR USE 

It Is a violation of FedoTal tew to uae this product In a mannor Inconalstant with Its labeffng, 

Road ontlr. label belore 1.I0ln9 thlo product. 

Do not apply this product in a way that will contact workers or other pefS(lns, either directly or through drift. Only protected handktrs 

may bo in the aroa during application. For any requiroments spocilic 10 your State or Tribo, consull Iho ag~ncy responsiblo for 

postiddo rogulalions. 

US/il this product only in accordanco with its laboliflg and With tho Workor Prot&Ctlon Standard, 40 CFR part 170. This slandard contaJns 

lor the protection of agricultural worimts on larms, forests, nursorios, and groenhouses, and handlers of agricultural 

It contains reqUIrements for training, doconlaml'nation. notilication, and emergency assistance. It also contains tpocific 

I and o)(ceptions penalning to tho statoments on this labet about personat protective oquipment (PPE), notification to 

and rostriclod-entry intervats. Tho requirements in this box only apply to uses 01 this product that are covered by tho Workor 

Standard. 

Do not onter or allow worlmr ontry into troated areas during tho rostricted-Mtry intervat (REI) 01 48 hours. 

PPE raquirad for earfy entry to troated areas that is pormltted undor tho Workor Protection Standard and that invotvos contact 

anylhing that has beon treatod such as plants, SO'lt or water is coveratls over short-steeved shirt and short pants, waterproof g<w".j 

c/lomical-rosistant footwoar plus socks. protective oyewoar and chomical-resistant headgear lor overhead exposure. 

II ti t II 

STORAGE 

Do nOI contaminato water, food, or fead by storage or disposal. 

If container is broken or contents havo spiffoo. fotlow all precautions indicated above and clean up immedialoly. Before cleaning up, 

on lull kingth trousors, long stooved shirl, protoctiv$lJloves. and goggles or lace shletd. Soak up spill with absorbent media such 

as sand, earlh or other suitable materiat and dispose of waste at an approved waste disposal facility. 

DISPOSAL 

>""iC;d, wastes are acutely hazardous. tmproper dieposal 01 excess pesticido, spray mixture, or rinsato is a violation 01 Fodoral law. 

cannot be dispos&d of by use llCCording to tabet instructions, contact your Stato Pesticido or Environmontal Control 

~:;,,/.':~I'=h:O Hazardous Wasto reprosontativo al tho noarest EPA Regionaf Oflice for guidanc4. 

DISPOSAL 

rinse (or equivalent) the empty containers, Then offer lor rocyclinlJ or reconditioning, or puncture and dispose of in a sanitary 

j "oa,,,,. or by incineration or if allowed by slato and local authoritios. by buming. If container is burnod, stay out of smoko. 

RETURNABLE ~~ REFillABLE CONTAINERS • • 

After uso, return the container to tho point 01 purchase or dosignated locations. This container must only be rofiflMIwTth-PREPm brand 

Ethophon lor Cotton and Tobacco. DO NOT REUSE THE CONTAINER FOR ANY OTHER PURPOSE. Prim " .... efifllng, I""""t/ 

thoroughlY for damage such as cracks, punctureS, abrasions and damaged or worn out threads on closure dov"" ••• -00 not 

transport damaged or toaldng containers. Check lor leaks aftor refilling and before transportation. For inlormation Q"0j,,\'lh;:':.~:;:~l:n unused, unwanted product, contact RhOne-Poulonc at 1-800-334-9745. For information on cfeanup of spJfls, 00""'''. R 

'-800-334-7577. If the container is not 

GENERAL INFORMATION 

COTTON 

•••• 

• •• •• • 

• 

• •• 

•• 

••••• • • • •••• 

A fotiar spray of PREPn< brand Ethophon will accolerato opening 01 mature unopened cotlon bolls and enhanca'l:W'ol!llJon which can 

result In earlior harvost with an increased rolcoverabte yield. PREpno brand Ethephon troatmont on cotton anows i~"s&d efficiency 

trom a once-over harvost. •• :. 

155 
TOBACCO (FLUE.CURED): A loliar spray 01 PRE pm brand Elhophon promotes early, uniform 'yellowing" of mature tobacco. 

PAEpni roduces curing hme, altowing mora eUicienl use of curing barn spaco, and increaseO control ovor harvest schedules. 

SPRAY PREPARATION 

Add 112 10 314 01 Iho raqulred amount 01 water to the spray lank. Start agitation, Add tho roquirod amount 01 PREpTh! brand Ethophon, 

and the remaining amount of water. Prepare only as much spray solution as can be used on tha day 01 mixing. Do not allow spray 

wlution to sland overnight. Do not spill the concenlrated product on spray equipmont, or any airplane parts. 

ANY SPILLS SHOULD BE RINSED IMMEDIATEl YWITH PLENlY OF WATER 

Use of a nurso tank is highly recommondGd for avoiding poSSIble spills of concnntratod lormulation on spray equipment or any airplane 

parts. 

TANK MIXTURES WITH DEFOLIANTS AND INSECTICIDES 

PREPll~ brand Ethephon Is compatible with DEP, FOLEX~, Dropp2, Harvade3. Mathyl Parathion, Guthionl, and Malalhion4• PREPN 

may be applied in sequonco or as a tank mixture (DO NOT TANK MIX WITH DESICCANTS IF COTTON IS TO BE SPINDLE 

HARVESTED). Follow all applicablo use precaulions and rata por acre racommendations on labels of products appliod as tank mixlures 

or in sequenco WIth PREP no brand Elhephon. fn somo cases slight reduction in boll opening response has been obselVed whon tank 

mixes with defoliants were used. 

Good agitation in tho spray tank is essential and a tank mixture should nol be allowed 10 stand withoul agitalion for more than 5 to to 

minutes, Road and obsolVe all appropriato label use directions and precautions for the dolobants and insecticides usod. 

NOTE: Under curtain conditions, tank mixtures of PAEprn brand Ethephon with desiccanls conlaining sodium chlorate could I 

result In tha lormation of hypochlorous acids which on h0ating will emit loxlc chloride lumes" 

EQUIPMENT CLEANING 

Because of tho acidic nature 01 this product, prolonged exposutE.' 10 spray deposit will damage acrylic plaslics, cottain paints, and 

malals. 

_inse thoroughly wilh a dotergont and water all ~xposed acrylic plastic·typo materials (e.g .. aircraft windshiakls), and painted surfaces 

within an hour alter exposuro to spray deposits. 

At the Gnd of each day, rinso thoroughly with a dotorgonl and wator all the motal parts oj tho aircraft and Ihe associaled spray 

equipment exposod to tho spray depoSIts . 

• ~ ". ,0; Lo pH:i<;ldo 

.; ""'';:~: 

• • •••••• • 

•••• 

• • •••• 

• .. " . · .. •••• • •• .. . · " .. . •••• 

•••• • •••• 

156 

• ••••• 

• •• 

• • 

• ••••• 

• .. • 

• •••• 

• • ••••• 
.. _._--

COTTON 

EXPECTED PREpru ONE'M SPRAY VOLUME APPLICATION 

USE CONDITIONS RATE (Gals/A) TIMING 

:: ';:' 

I LBS A.I. Acr •• Air" 

PREpN Hot and dry 80~F or t 113 1.0 6 Apply whon tho numoor 01 

Bal! Opener' highor mature unoponod bolls is 

Dry and 75 to 80~F 2 1.5 4 15 ·50 2·5 

sulficiont to produce thO' 

desired crop. Seo below tor 

Coo! but above 65~F 22/3 2.0 3 tost 01 boll maturity. 

Troatmont uniformly opens or bolls 7 to 14 days earlier. 

Aaok cotton 

PREP~ + High SOil moisture 1.'3 0,25 24 15 ·50 5 ~ to Apply 4 to 7 days prjo~ to 

FOLEX3' or PREp'N' boll opening 

Defoliant Tank High lortility level application. To be used. as 

MIx or a so~u~~~', treatmont with, not in 01 PREpm boll 

Aank cotton I 

PREprn. OtOpp2 High sod moisture 113 0.25 24 to·50 3· to Apply 4 to 7 days prior to 

Tank High fertility lavel PREpm bol! op~ning 

MIx Rank cotton application. To be usod as a sequential treatment with, 

not i~ pl~ce ~I PREpn4 boll 

Pr.~Candftlon.r Hot, dry, 213 0.5 12 Apply 4 to 7 days prior.~~ 

lor OafoJfatton Cool, above 65Gf t 113 1.0 6 t5-50 2·5 defolianl. Enhances top 

or crop deloliation reducing 

;;;.riOratkm 01 bottom crop Rank col1on allows for earlier 

·Pretreatment With Defoliants Prior 10 PREprn Boll Opening Treatment 

If the cotton is overly rank or laying down in the mlddl •• and good spray coverage 01 tho bolls with PREPTJoI Is difficult, a pretreatment 

with defoliants will be U$etul to Improve boll coverage with PREpni. Us. dosago rales of PREpTJoI brand Ethephon recommended for boll 

opening, Read and obsGrvo aU aPPropriale label use diroctions and precautions lor tho d&ioliant usoo. 

"In California and Arizona use a volume of no los$ than 5 gallons por acre for aorial applications. 

Boll Maturity 

~ boll is maturo when it is too hard to bo donted when squeezed ootween thumb and tingors, 100 hard 10 be s!icod with a-sharp knllo, and 

W'.hen the seed coat bocomos light brown in color. 

Use Limitations 

00 not O)(coed a maximum ot 2.0 lb. ailA tor combin!)d uses at PAE~ por aero per year. 

Boll Oponing: Do not tank mix PREpnI brand EthephOn with a desiccant if tho col1on is to be spindle harvested. 

Pre-Condition tor Dofoliation: Do not tank mix PREP"" with desiccants unloss plant desiccation is required. Do not use a detoliant 

bofore there is sufficienf mature unoponed bolls to prodUC8 tho desired yield (soo Generallnformalion S&CI.ion on how to tost for boll 

maturity. 

WHEN TO HARVEST COTTON , . , 

•••••• 

00 not harvost ootton soonor than 7 days after a treatmont with PREP"" brand Ethophon. • ••• , , Observo the lrealed crop and harvest when optimum bon openIng has boan reached. Too early harvest might rGdut''1~efull advantaga 

of the treatment and too late a harvGsI may result in roducod quality and loss of lint which WIll drop from the plant.· : •• :.: 

••• • • " , • •• • ••••• 

, •••• , . . , , 

, . .. ••••• , , • • •••• , .. " , •••• 

••• 

, • 

•••• 

157 ..................... ----~--.... -........ ----................ --.. . ... _----

/ 
PREpTU ."P'.Y 

f6BACCO 

(Flue-Cured Only) 

Crop Situation Ptnts/Acro AC~~SI Spocitlc Olnctlons 

Dirocted Spray I 1/3 50 ·60 Usa drop nozzles. Choose TG or OC spray tips designed to apply 50 . 60 

Application gpa at 35·40 psi and at tractor spoed 01 2·3 mph. Uso 

2 nonl" PO:::;llr:,~:i:;~'h .ido ollho 'ow d"'ppod low onaugh 10 dimel tho spray to I to be riponed and harvosted. Thorough .~£'.~~~ 

. . a dirOC1od spray, be sure to harvest all 

!wrth20%m i . 

Over-The-Top t 113-2213 40-60 Troat only when leaves romaining on tho stalk are mature. To 

Applicarion romaining loaves aro maturo. tost spray sovernt tobacco plants as 

describGd undor the section "Proper Time 01 Treatment: Use the /ower rate 

in a normally mature crop when oxporionco indicates that minimum riP~n~~ 

inducement is r&quiroo. Use the higher rate whon the crop is hoavy and 

a tondency to be more rank or whGn tomperaturos are lower than normal. 

Always test spray to delermino if the tobacco is mature onough to respond 

to treatmont with PRfPThI brand Ethophon. 

Apply ovaHhe·top PREpl"- brand Ethephon spray as a fine mist using throo 

nOlzles (one nozzle tips over the cantor 01 tho plant. and one on oach side) 

so all 1f}:a:~~~;~~I~~[~d similar to the Ii ~+60 :~~ern 01 . I aoonl,. tis.a I 40 10 . 

USE LIMtTATIONS 

Do not apply PREpm brand Ethephon to immaturo leavos as rhis can result in unsatislactory coloring. waight loss and roduced loaf 

quality_ 

00 not allow tho crop to over ripen in the freld after using PREPrn brand Ethophon, since this may cause somo roduC1ion in yield and 

quality, 

Do not treat boloro anticipatod major storm which could prevent halVest and result in crop loss. 

00 not apply PREP"" brand Ethophon if rain is oxpoctod within 4 hours. 

APPLICATION 

successful~,~O~,":~':";~o~:p.~~~;~~~;~:~;:~;~~}::;;~ are maturo, not overly rank groon when sprayed. To oaslly detormlne the proper harvest. test spray sovorol plants in moro than one location in / 

oach field in 24 to 72 hours, Test loaves that fall to yotlow in 72 hours aro 

not matUlo ;~iEih"Ph;'~·i,;.;t';';,otWait a low days to permit lurther natural maturing, thon make 

another tost 

CURING PREpm TREATED TOBACCO 

Curing procedures oro as much an art as a sao-nco and oach cur. must be iudged on the basis of tObT~~;~.~~l~::,~:~~~:~E lreatmont and harvest, weathor and typo of curing facility boloro proscription temperatura and 

established. To obtain maximum quality, care must bo taken to obsolVo and conlroltho curing procoss I 

[ate ·coloring- and early "drying- stages of tho loaf. 

• • 

PREprw: brand Ethophon treatod tobacco will have started tho coloring procoss whon harvosted, reducIng the tim.fe"q1J1rad in tho •• 

coloring phaso of ClJring. Treatod tobacco should be dried lastor. If tobacro l6avos are 9roon or contain somGgreGn wlfon haMlMl. 

it may bo nocossary to color thorn for a low hours. If lhe leaves are complntoly yollow. tGmpora1ure and ventilation mtTsl be adjMftltrln 

a manner to dry the tobacco as fast as possiblo without scalding. Once the leaf is dried (3/4 dry), you should folloJV Qd~al procGdures 

tor curing. Sinco PREpl>! brand Ethophon treatod loaves cure tastor. tmatod and unlreated leaves should not be ctmtogethor in tho 

sarno bam. • ••• 

..... • 

158 
~~~~-~-------~~~~~----~-~-~----

LIMITED WARRANTY AND DISCLAIMER 

ThQ manufacturor warrants (a) that this product conforms to tho chQmical doscrlption on tho labol; (b) that this prOduct is roasonably Iii 

lor tho purposos sot foJ1h in tho diroctions for use when it is used in accordance with stroh directions; and {el that tho directions, 

warning and other statoments on this label are based upon rosponsibfo expons' evaluation 01 roasonabJQ tests 01 effectiveness, 01 

toxicity to laboratory animals and to plants, and of rosiduos on food crops and upon roports of field 9XporiQOCO. Tests have not been 

made on all varieties or in all slmos or undQr aU condilions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES, EXPRESS OR IMPLIED. AND IT 

EXPRESSLY ExcLUDES AND DISCLAIMS All IMPLIED WARRANTIES OF MERCHANT·ABILITY OR FllNESS FOR A PARTICULAR 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS, WARNINGS OR CAUTIONS, 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES. DAMAGES, OR INJURIES RESULTING fROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT. NEGLIGENCE. STRICT LiABILITY IN TORT OR OTHERWISE SHALL BE LIMITED, ATTHE MANUFAClURER'S OPTION, 

TO REPLACEMENT QF, OR THE REPAYMENT OF THE PURCHASE PRICE FOR. THE QUANTITY OF PRODUCT wm; RESPECT TO 

WHICH DAMAGES ARE CLAIMED, IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR 

CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING Of lHlS PRODUCT. 

NOnCE TO BUYER 

Purchase 01 this product does not contor any rights undQr patients govQrning this product or tho use thoraof In countries outsido 01 tho 

Unilorl States. 

elDEF and Guthion arGo rogistorod tradomarkS 01 Bayor AG. Germany, 

7Droppis a registered Iradomark ol NOR·AM Chomical Company. 

3Harvado is a rogistfJrod trademark 01 Uniroyal Company. 

4Malathion is a tradomark of Amorican Cyanamid Company . 

• 

RhOno·Poulonc Ag Company 

P.O. Box 12014, 2 TW. Alounder Drivo 

Res&arch T rianglo Park. Nol1h Carolina 27709 

PREP is tho tradomark of Rh6no·Poulonc. 

FOLEX Is a registered trademark of Rh6no·Poulenc. 

PREPIM brand Ethophon for Collon and Tobacco (PENDING) Submitted tOf_l94. 

• • •••••• • 

•••• • • •••• 

• .. . •• • · .. •••• 

• ., •• . 

• · •• .. • •••• 

• ••• 

• • ••• 

159 

/ 

• ••••• 

• • • • • 

• ••••• 

• .. • 

• •••• 

• • • •••• 
'. 

• 

• 

I!l!IIO!W!DU!! 

SUBJECT: 

FROM: 

TO: 

THROUGH: 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OCT 24 1994 

OFFICE Of 

PRE\I£NTION, PESTtCID£S AND 

TOXICSueSTANCES 

Addendum to the ORES Analysis for the Ethephon 

Reregistration Eligibility Decision Document 

Stephen A. Schaible ~;;1~ Dietary Risk EValuation Section 

SAB/HEO (7509C) 

Jane s. Smith 

Reregistration Section 

CCB/HEO 

Elizabeth A. Doyle, Head 

ORES/SAB 

Health Effects Division 

(7509C) 

L.q .~ .. .AI:t~/ (7S09C) ty!l'-' 

Percent of crop treated information supplied by BEAD in a L. 

Luben memorandum to C. Lewis dated 12/13/91 was inadvertently 

omitted from consideration at the time the ORES analysis for the 

RED was performed; the analysis for the RED is described in a S. 

schaible memorandum to J. Smith dated 10/11/94. More recent 

information than that supplied in the Luben memo was incorporated 

into the RED analysis through a J. Hogue memorandum to J. 

Loranger dated 9/26/94, but refined estimates of percent of crop 

treated exist in the Luben memo for crops which are not included 

in the Hogue memo. 

The previously omitted percent of crop treated information 

was added to the ORES file for ethephon, and a chronic exposure 

analysis was performed. Because percent of crop treated 

information is not used in the ORES acute exposure analysis, and 

ethephon is considered a Group D carcinogen, only estimates of 

chronic, non-cancer exposure and risk are affected by the 

addition of this percent of crop treated information. 

The residue inputs and toxicologica1 endpoints to which 

chronic exposure is compared remain the same as those described 

in Schaible's 10/11/94 memo; please refer to that memo for 

discussion of assumptions which went into this analysis and for 

residues and toxicological endpoints. 

Where percent of crop treated estimates are given in both 

BEAD memos for a crop, the estimate in the Hogue memorandum was 

used, being the more recent. 

A summary of the residue and percent of crop treated 

information which was used for this analysis is attached as Table 

1. 
". 

• 

• 

Results of ORES chronic analysis 

As was done before, two ORES chronic exposure analyses were 

performed, the first including uses recommended for revocation in 

the Tolerance Reassessment Summary of the Residue Chemistry 

Chapter of the RED and the second excluding these uses. TMRC 

estimates described in the previous Schaible memo are not 

affected by this analysis, only ARC estimates changed. Summaries of the ARCs and their representations as 

percentages of the RfO are attached as Table 2 (including 

recommended revocations) and Table 3 (excluding recommended 

revocations). 

The ARC for the U.S. population published tolerances only 

are considered is 0.001572 mg/kq b.wt/day I which represents 8.7% 

of the Rfo. When residues in poultry and eggs, the recommended 

increase in the tolerance on cottonseed, and the proposed 

tolerance for "apple juice" are: considered, the ARC is raised to 

0.001624 rnq/kq bwt/day, or 9% of the RfO. The ARC for the 

subgroup most highly exposed, non-nursing infants less than one 

year old, is 0.008227 rnq/kq bwt/day (46% of the RfD) from 

published tolerances and 0~008781 mg/kg bwt/day (49% of the RfD) 

from published, proposed and recommended uses. 

If published tolerances recommended for revocation are 

excluded, the ARC for the overall U.s. population from all uses 

recommended through reregistration (including poultry and eggs, 

the increased tolerance on cottonseed and the proposed tolerance 

for "apple juicell ) is 0.001553 mg/kg bwt/day, or 8~6% of the RfD. 

The ARC for non-nursing infants less than one year is 0.008427 

mq/kq bwt/day, or 47% of the RfD. 

These risk estimates should replace the chronic estimates 

supplied in S. Schaible's 10/11/94 memorandum for use in the 

ethephon RED. The discussion in s. Schaible's 10/11/94 memo 

regarding th'e use of the ORES default of 100% crop treated for 

uses recommended for revocation where percent crop treated 

information was not available or was more than 5 years old is 

still applicable, though fewer crops are affected by this policy 

with the addition of the percent of crop treated information 

provided in Luben's 12/13/91 memo. 

Attachments 

cc: ORES, PM 22, Caswell # 42,6A 

161 
l #426A 

CAS No. 16672-87-0 

A.I. COOE: 099801 

CrR No. 

FOOD CooE ,000 

01002AA 

0100ZAA 

0100211." 

b1009AA 

01009AA 

01G09M, 

01009M 

01010AA 

01010 ...... 

01010M. 

01010JA 

01010JA 

'01014/1.A 

01014M 

01014M 

0101401'1 

010140/1. 

0101401'1 

01014JA 

01014JA 

Ol014JA 

02004AA 

020(tJ,M 

0200411.8 

02004A9 

02004"1'1 

02004)111. 

02004JA 

02004JA 

02004JA 

OZOO4JA 

02oo7M 

0200BAA 

02008JA 

03005AA 

03005M 

.03005AA 

03007M 

03009AA 

030G9M 

, , 

BLACKBERRIES 

BlACIC8£RRIES 

BLACKBERRIES 

BWEBERRIES 

BLlJ£BERR1ES 

BLlJ£SERRIES 

BLUEBERRIES 

CRAMSERRIES 

CIWf8ERIU ES 

CRAIfflERRIES 

CRANBERRY-JUICE 

CRANBERRY~JUICE 

GRAPES-FRESH 

GRAPES- FRESH 

GRAPES· FRESH 

GRAPES-RAISINS 

GRAPES·RAISINS 

GRAPES-RA1 SINS 

GRAPES-JUI CE 

GRAPES-JUI CE 

GRAPES-JUICE 

LEMOHS·UNSJ'EC 

L£MOHS-UNSPEC -

LEKOtIS'PUtP 

LEMONS-PUlP 

LEMONS-PEEL 

LEMONS·PEEL 

LEMONS-JUIcE 

LEOs, JUICE 

LEbS-JUICE 

LEMONS-JUICE 

TANGELOS 

TANGERINES 

TANGERINE' JUICE 

F1LBERTS 

FILSERTS 

fIlBERTS 

HACAOAMIA MlJTS 

WALNUTS 

, WALNUTS 

.............. / -"~-

1.~okw 12/:;11~1~;; 

."'. .""" /''<11',-

C. /..f...(W ~7A'A'lf_(n~~ 

TAl\l.~ 1. 

AtHICIPATEO RESIDlIE INFORMATION FOR CASW£LL MMBER 42M DATE: 10/14/94 

LEL= 

FOOD FORM 

10 RAW'FRESlI OR NFS 

21 Coot:::EO'IIFS . 

62 COOKED-FRESH 011: FROZEN-BAKED 

10 RAW- FRESH OR MFS 

21 COOKEO'NFS 

22 COOKED-FRESH-SAXE!) 

62 COOKEO-FRESH OR FROZEN' BAKED 

10 RAW-FRESH OR NFS 

21 cro;EO'NFS 

31 COOKEO-FRESH OR CANNED 

15 RAW- FRESH OR CANNED 

31 CQOICED-FRESI/ OR CANNED 

10 RAW' FRESH OR HFS 

21 COOKEO·MFS 

31 COOKED-FRES" OR CArtHED 

10 RAW' FRESH OR NFS 

21 C()(M(ED-NFS 

22 COOKeO~FRESH-BAKEtl 

10 RAW-FRESH OR NFS 

15 RAW' FRESH OR CANNED 

21 COOIC£O-NFS 

10 RAW-FRESH OR NFS 

22 COOKEO-FRESH'SAKED 

10 RAW' FRESH 011 NFS 

31 COOKED-FRESH OR CANNE{) 

10 RAW' FRESH Ill: NFS 

21 COOI(El)-NFS 

10 RAY-FRESH OR NFS 

15 RAW· FRESH OR C,IINNEO 

21 COO(£D-NFS 

31 COOKED- FIIESH OR C,IINHEO 

10 ItAW"FIU:SH OR IIFS 

10 RAW-fRESH OR KFS 

15 RAW-FRI;SH Ol! CAIfNEO 

10 RAW-FRESH OR NFS 

.21 COOKEO-NFS 

22 COOk:EO-~RESM-8AkEO 

10 RAW-FRESH OR NFS 

10 RAW' FRESH OR HFS 

21 C~O.NFS 

• 

TOlERANCE AIITICIPATEO 

PET.f (ppm) RESIDUE. (FPII) AR STATISTIC T'fPE 

,,,,.. 

9E2262 ", ... 9£2262 

9£2262 

9£2262 

9£2262 ". 

3F1353 

3F1353 

3F1353 

3F1353 

3F1353 

9F2118 

9F2178 

9F2178 

9H5207 

985207 

9H5207 

9F2178 

9F2178 

9F2178 

9£2262 

9E2262 

.. 2262 .. ,,., 

91:2262 ""62 9£2262 

,., ... 9£2,., 

9£2262 

.. ,,., 

9£2262 

9£2262 

3F1344 

3F1~4 

3F1344 

""., 

NO PET' 

NO P'ETt' 

P 30.00000 

,. 30.00000 

P 30.00000 

P 20.00000 

P 20.00000 

P 20.00000 

P 20.00000 

P 5.000000 

P 5.000000 

P 5.000000 

P 5.000000 

P 5.000000 

P 2.000000 

P 2.000000 

P 2.000000 

P 12.00000 

P 12.00000 

P 12.00000 

P 8.000000 

P 8.000000 

P 8.000000 

P 2.000000 

P 2.000000 

P 2.ClOOOOO 

P 2.000000 

P 2.000000 

P 2.000000 

P 2.0000c0 

P 2.000000 

P 2.000000 ,. 2.000000 

P 0.500000 

P 0.500000 

P 0.50000a 

P 0.5DOOOO 

P 0.500000 

P 0.500000 

P 0.500000 

P 0.500000 

P 0.500000 

18.400000 

7.360000 

7.360000 

8.540000 

3.420000 

3.420000 

3.420000 

0.350000 

0.27OQ()0 

0.270000 

0.350000c 

0.35000OC 

0.350000 

0.350000 

0.350000 

0.70oo00C 

0.700iWIC 

0.70000OC 

0.370ool)C 

0.37tlOOOc 

0.37OOOOc 

3.610040 

3.61000Cl 

0.410000 

0.410000 

3.610000 

3.610000 

0.150000C 

0.1500ooc 

0.15OO00c: 

0.1500(JOC· 

0.040000 

0.040000 

0.020000c 

0.130000 

0.130000 

0.130000 

0.005000 

0.0300(I(I 

0.030000 

• 

% CROP TREATEO 

1.00 

1.00 

, .00 

100.00 

100.00 

100,00 

1(10.00 

6.00 

6.00 

6.00 

6.00 

6.00 

7.00 

7.00 

7.00 

7.00 

7.00 

7.00 

7.00 

7.00 

1.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

54.00 

54.00 

54.00 

54.00 

11.00 

11.00 

PAft¥:: 

R£S. VA!.U£ USED 

IN TAS fWM (PID) 

0.184000 

0.073600 

0.073600 

a.s40000 

3.420000 

3.420000 

3.420000 

0.021000 

0.016200 

0.016200 

0.021000 

0.021000 

0:024500 

0.024500 

0.024500 

0.049000 

0.049Q00 

0.049000 

0.025900 

0.025900 

0.025900 

3.610000 

3.610000 

0.410000 

0.410000 

3.610ll00 

3.610000 

0.150000 

0.150000 

0.15ooot1 

0.150000 

0.040000 

0.040000 

0.020000 

0.070200 

0.C170200 

0.0702<lO 

0.002700 

0.003300 

0.003300 
ANTiCIPATEO IlESIOIJE 1IfF~TlON FOR CAMll IMtSI:R 426A OATE: 10/14}94 PAGE: 2: 

iL SToo'l' TYPe . EfFECTS RHERENCE OOS£S DATA GAPS/COMMEIITS STATI,i$ 

IIIA11ln 28 day Study Oiarrhea, urgency of bow- AC1 UF -->100 No dota gaps. NED easphrte 03108}88 

l #426.\ NOEL" 0.0000 IJIlJIkg el movements, urinary OPP R1O= 0.018000 EPA wrlfied 03/23}88 

CAS Mo. 16672-87-0 0.00 ppII\ urgency. stlllllKh crl!llllpS; EPA RfD" 0.005000- WHO \ .. t rtVfewed 1993 

A.I. COOE: 099801 LEL'" 1.8000 III9Ikg ck!<:r or incr in appetite_ RtD/PR reviewed 02/10}94 

CfR NO. 180.300 0.00 ppt No evfckmce of ClH'Clnog18'5.2700 DttCO: Tent E -(IID/N) enlclty In rab & Illlee. on IRIS. 

TOlERANCE ANTICIPATEO It£S. VALUE USED 

C') 

CO 

.--

"'''' -

'000 FOOO FORM PET.tI (ppII) RESIDUE (ppm) AIt STATISTiC TYPE % CftOfI TREATE!) I II TAS RW (ppII) 

03009AA 

o.r.OO1M 

04001AA 

0400IAA 

04001M 

04001DA 

04001DA 

04001,. 

04001JA 

04001JA 

04001JA 

04001JA 

05002,. 

OSOO2M 

.,00'" 

-

O'!102DA 

G5002JA 

{

=: 06005,. 

06005M 

....... 

06<l06M 

-

06013AA. 

06013M 

06013M 

060130A 

06013JA 

06013JA 

06013JA 

06013JA 

~07OO2AA _"'. l0002AA 

1000,.. 

l0002A11 

P0010M 

11001CAII 

'. > 

~LNUTS 22 COOKED'FRESII-BAkED 

APPLES-FRESH 10 RAW-FRESH OR IfFS 

APPLES-FRESH 21 COOKED'lfFS 

APPLES·FRESK 31 COOKED-FRESH OR CANI!ED 

APPLES' FRESH 62 C{)(XEO'FRESII OR FTWZEN-IlAAEO 

APPLES-ruUED 10 AA\ol·fRfSK OR IiFS 

APPlE$-nRIED 22 C:OOK.E1)·F!t£SH-&AaO 

APPlES'DaIEO 62 coc«m'FRESIi 011 fROl£N'IIAK£O 

APPLES-JUICE 15 AAW-FRESH ()R CMHi£C 

APPLES' JUICE 15 RAW-fRESH OR CNfIfEO 

APPLES-JUI CE 31 COOKUHRESH OR CAHUO 

AmES-JUICE 31 COOK£D-FRESH ()R CAttI/EtI 

CMERR1ES-FRESII 10 RAW-fRUH OR IfFS 

CtffAAIES-rRESIi 21 1XlOK£0-HFS 

CIlU1UES-FRESK 31 C{)(XED-FRES!I OR CA~ 

CM£lUtlEs·nESH 62 cootJ:1)-FRESH OR fROZeM-8AKfD 

CHERRIES-DRIED 00 MOT SPt;CIFletl (NO CONSVlWTlOIt) 

CMEIUlIES-JUlce 15 !tAlHRfSH OR CM/NtD 

CI!£RRIES-JUICE 21 COOKED-IiFS 

FIGS 10 AAW-FRfSII CIt HI'S 

FIGS 21 COOKE'O-MfS 

F1GS 22 COOICEO-fRESH-8AKfD 

GOAVA 10 RAW-FItESM OR MfS 

GUAVA 21 COOK£l)-NFS 

GUAVA 62: COClkED-FRESH OR FlWZEIHMI(ED 

PINEAPPLE-PUlP 10 RAW-FRESK OR: HFS 

PIft'M"PlE·P.U1.P 21 COCllC£t)-NFS 

PINEAPPLE'PUlP 31 COO(ED-F!U:SK OR CANIiEtl 

PI~E-ORIED 10 RAW-fRESH OR'M'S 

P1~LE~JUICE 10 RAW-fRESH OR MFS 

PIIffI\PPLE-JOICE 15 RMl-FR£SM OR CAMMal 

PIMEAPPLE~JUICE 21 COOKED'lfFS 

PINE~LE-JUICE 31 COOKEO-FRESH OR: CANNED 

COfFEE 21 COOK£O-IfFS 

PAPR1KA 00 IIOT SPECifiED (NO COffSUWTiO'H 

CAMTALIXSPES-UtiSP 00 IklT SPECIFIED (NO CONSUHPTlOH) 

CANTALOIJPES-PUlP 10 ItMHItESH OR MFS 

CANTALOUPES-PUlP 21 ~-NFS 

Cl..IC\M8ERS 10 RA',.,.RESK CIt HFS 

C1..ICtJM8ERS 11 RA\I-FRESII-PICK1ED,CORHED,OR CURED 

• 

HO PUt 

3f1325 

3f1325 

3f1325 

3F1325 

3F1325 

3F1325 

3F1325 

3F13-21 

3f1325 

3F1321 

31'1325 

3F1321 

3F1321 

3F1321 

3f1321 

3f1321 

·3F132:1 

3fl321 

4F1490 

4"490 

4f1490 

NO PET# 

NO PETif 

\I/O PEl. 

m016 

1f1016 

1f1016 

1f1016 

1f 1016 

1F1016 

1f1016 

1F1016 

4F1490 9£_ 

2F127'S 

2f1275 

2:F12:75 

9£2225 

""205 

P 0.500000 

P 5.000000 

P 5.000000 

P 5.000000 

P 5.000000 

P 5.000000 

P 5.000000 

P 5.000000 

M 5.000000 

P 5.000000 

It 5.000000 

P 5.000000 

P 10.00000 

P 10.00000 

p 10.00000 

P 10.00000 

po 10.00000 

P 10.00000 

P 10.00000 

P 5_000000 

p- 5.000000 

P 5.000000 

P 0.100000 

P 0'.100000 

P 0'.100000 

P 2.000000 

P 2.000000 

P 2.000000 

P 2.000000 

P 2.000000 

P 2.000000 

P 2.000000 

P 2.000000 

P 0.100000 

p 30.00000 

P 2.000000 

P 2.000000 

P 2.000000 

P 0.100000 

P 0.100000 

0.030Cl00 

1.710000 

1.710000 

1.710000 

1.710000 

1.710000 

1.710000 

1.710000 

1.710000c 

1.710000C 

1.710000c 

1.710000c 

3.400000 

3.400000 

1.610000 

3.400000 

3.400000c 

3.400000c 

3.400000c 

2.300000 

'.300000 

2.300000 

0.100000 

0.100000 

0.1ClOOOO 

0.200000 

0.200000 

0.2(I0000 

0.200000 

0.100000c 

0.100000c 

O.100000c 

0.100000c 

0.010000 

1.070000 

0.270000 

0.270000 

0.270000 

0.005000 

0.005000 

• 

11.00 '.00 

'.GO 

'.00 

'.00 

'.00 '.00 '.00 '.00 '.00 '.00 

9.00 

,.,00 

30.00 

3<).00 

"'.00 

30.00 

"'.00 

30.00 

'.00 

'.00 

5.00 

100.00 

100.00 

100.00 

23.00 

23.00 

23.00 

23.00 

23.00 

23.00 

23.00 

23.00 

100.00 

9.00 

2.00 

'.00 

2.GO 

3.00 

3.00 

0.003300 

0.153900 

0.153900 

0.153900 

0.153900 

0.153900 

0.153900 

0.153900 

0.153900 

0.153900 

0.15l9OO 

0.153900 

1.0z0000 

1.020000 

0.483000 

1.020000 

1.020000 

1.()2_ 

1.020000 

0.115000 

0.115000 

0.115000 

0.100000 

0.100000 

0.100000 

0.046000 

.0.046000 

0_046000 

O.ll46OOO 

0.023000 

0.023000 

0.0'23000 

0.023000 

0.010000 

0.096300 

0.005400 

0.00S400 

0.005400 

0.000150 

0.000150 

,,---_._-------------
ANTlC1PAlEO RtSIOOE 1NA:mMT1ON FOR CASWEll iruMSER 426A OATE: 10/14/94 PAG£: 3 

'''''''' "'" NOEL- O.OOOO·mg/l':g I-et ~ts~ ut"1nary I OPP RfO: O.Oleooo I I EPA verified 03/23/88 CD 

CAS No. 166n·S7-0 O.M 

- .... -...... .. .. .-d. .... .....,... ~PA ~+n: n.~~ IoINO lut l"O!Vi-.t 19Q1 ..-

A.I. CCOEt 099801 LElCFR No. 180.300 

85.2700 OWCO: Ten E • " enidt i" rats &. aice. On IIUS. 

TOLERANCE ANTIC1PATEO RES. VALlIE I,IS1;O 

FOOl> COOE FOOO FOOO ""'" flET •• <"", ItESIOUE (pPa) AI STATISTIC 1YPE % CROP TREA lEO IN TAS RiItI (PPI\) 

~ 1001QAA CUCINE" 21 ctUm·NFS 9£2225 P 0.100000 0.005000 3.00 0.000150 

;\ l0011AA PVHl'KIM 2:1 COOI(EO·NF$ 3£2814 P 0.100000 0.02'5000 100.00 0.025000 

\10011M PUMPklH 22 COCJ(EO- FRESH·ilIIk'ED 3£2814 P 0.100000 0.025000 100.00 0.025<100 

,10011AA PUMPkIN 62 COO(EtHRESH ott FR02EtHIAt'fD 3£21114 P 0.100000 O.OZSooo 100.00 0."""'" 

11".,..... PEPPERS,SWEET 10 R,w-FItESH OR NFS 9£2262 P 30.00000 0.830000 23.00 0.190900 

11003M PEPPERS, MET 21 COOkEf)-NFS 9£2262 P 30.00000 0.830000 23.00 0.190900 

"""" CHILI PeI'J'ERS 00 NOT SP£C1 FiEO (NO coeIS!.WlIOII) 9£'262 P 30.00000 1.070000 9.00 0.096300 

11003A1> PEPP£RS'OYIlER 10 RA\HItESH OR NFS 9£2262 P 30.00000 1.07OOO(J '.00 0.096300 

"""" PEPPERS-OntER 21 COIXE1HtFS: 9£2262 P 30.00000 1.07tlOOO 9.00 0.1I963IlO 

1100lAO PEPPERS·OfI!eR 51 COOICEO·CANNEO 9£'262 P la.OOOOO 1.070000 9.00 0.096300 

11004AA PHUEltlOS 10 'WHRESM Oft NFS 9£2262 P 30.00000 O.~OOOO '.00 0.057600 

11004M PIMIENTOS 21 COOKElHIFS 9£'262 P 30.00000 0.640000 9,00 0.057600 

"""'" P1MIENTOS 31 CCXJt::El)-FItESM OR CMlNED 9£2262 P 30.00000 0.640000 9.00 0.057600 

11005AA TQoIATOES·WIiOlE 10 RAW· FRESH OIl NFS 3Fl321 P 2.000000 0.570000 22.00 0.125.1jOO 

"""'" TOMA.TOES ·wtiOt.E 21 COC*:Et·IIFS 3F1321 P 2.000000 0.570000 22.00 0.18400 

11005M iCMA. TOES·\oIMOlE 31 cOOI:.m-FRESIf OR CANIfEl) 3F1321 P 2.000000 0.510000 22.00 0.125400 

11005JA TOOTOES·JUICE 10 RAW·fRESIi ~ liFS 3F132:1 P 2.000000 0.120000c 22.00 0.026&00 

11005JA rcmTO(5·JUltt 21 coot:: En' It F S 3Fl321 P 2.000000 0.12OOOOC: 22.00 0.026400 "_ T<:&TOES·M£E 10 RAW-fRESH OR NFS 3F1321 P 2.000000 0.01 ClOO(lC 22.00 0.002200 "_ TQ!ATOES·PU1tEE 21 CtXlKEO-NF$ 3F1321 P 2.000000 0.010000c 22.00 0.002200 "_ TOMATOES·POREE 31 COOKED-FRESH OR CANM£D 3F1321 P 2.000000 0.0100D0C 22.00 0,002200 "_ TCMA.10ES·POREE 32 CC!OKEO-FRfSM OR CAHlfEO-8AtEO 3F1321 P <:.000000 0.010000c 22.00 0.002200 

11005RA TIlI4ATOES·POIIEE 51 COOKED·CAMm 3F1321 P 2.000000 0.010000c 22,00 0.002200 

11005TA TCWoTOEH)A$TE 21 ct:Xll;:ED-NFS 3F1321 P 2.000000 0.57OOOOc 22.00 0.125400 

11005TA • TQltATOES'PASTE 22 coot::£l)·FRESIl-iIAK'EO 3F1321 P 2.000000 0.57OOOOc 22.00 0.125'00 

11005TA Tot{ATOES-PASTE 31 et:)IXED·FRESIf 011: CAN\liED 3F1321 P 2.000000 0.57OOO(lC: 22.00 0.125liOO "_ TOMATOES-CATSUP 21 CClOKa)'MFS 3F1321 P 2.000000 0.570000C 22,00 0.125400 

24oo1M BAAlEY 21 COOKED-NFS 2F2711 P 2.000000 0.190000 1.00 0.001900 

24007M WM£A T· ROl.IGH 10 RAW·FRESII OR NFS 2F2711 P 2.000000 0.06800II 1,00 0._ 

2.1j007AA WEAr ·1tWGK 21 COOKElHIFS 2F2711 P 2.000000 0.""""" 1.00 0._ 

24oo7AA WHEAT-RWGH 22 COOKED-FRESK·BAKED 2F2711 P 2.000000 0.060000 1,00 O. """'" 24007AA WKEA T-RO!.IGH Z3 COOICElI-FRESM'BOIlED 2F2711 P 2.000000 0,""""" 1.00 O. """'" 24007GA WMEAT-Q£RH 10 IWl'FRESH OR HFS ZWS357 P 5.000000 0.136OOOC 1.00 0.001360 

2400i'GA WilEAT·GfIlM 22 COOKEO·FRESII·8AkED 2115357 P 5.000000 0.1360001: 1,00 0.001360 

2400"" wtlfAr·8RA11 10 RA\HRESM OR NFS 21IS357 P 5.000000 0.23MOO1: , ,00 0.00Z380 

24001HA WHEAT·BRAH 21 Ct)(XEfI·NFS ZM5357 P 5.000000 0,_ 1.00 0.0023S0 

24007HA \!HEAT-BRAN 22 CO(J(£g-F/u:SII·tw:ED 2H5357 P 5.000000 0.23BOOOC 1.00 0.0023S0 

''''''''' \lllEAT·FlOOR 10 f!A\/-FRESH OR NFS 2F2711 P 2.000000 0.1I06SOO 1,00 0.00006Il 

24007WA WMEAT·FLOJl 21 COOK'fl)-NFS 2F2711 P 2.000000 0.006S00 1.00 0.00006II 

2.1jOOiVA WHeAT-FlOJR 22 OOOKED·FRESH·BAXEO 2F2711 P 2.000000 0.006S00 1.00 0.0<10068 

, , • • 
ANTICIPATED RESlotJ£ IIIFOO"tlATJOff FOIl: CASWEll M!R'!SER -4261. DATE: 10/14/94 PAGE: 10 

'L STlOY TYPE EFFIICfil: lEFtREliCE OO$fS. OATA IITS STAtus 

~ 28 d.y Study Olm-mea, unreney·of boW- ADI UF ·-:0100 Nt! data 98P$. Mal coarptet~ 03/04188 

Ceswl! #4261. MOeL.. 0.0000 lII9/kg ~I ~II. ur!,...ry 0Pf' RfO>< 0.018000 EPA verified OJ/23/88 

CAS Mo. 166n-S1-0 • 0.00 pPf!I urgency, stOllltdl cremps; EPA RfO>oo 0.005000 WHO tut rev!~ 1993 

A.1. COOE~ 099S01 LEL" 1.8000 II'GIl:g docr or incr in appetite. RfO/PI reviOW«f 02110/94 

CFR No. 180.300 0.00 pp!II No evldenoe of carcfnogt100 OMoo: Ttnt E-(RfO/Pi'; tnleItyin rets & mice. On HUS. 

TOLERANCE AHTlC1"PAIEO 

FOOO COOE FOCI) FO<X> """ PET.' (~) RESIDUE (pp!II) Nt STATISTIC IYPE % CROP TREATEO 

RES. VAlUE usa> 

IN TAS 1WN (pPII) 

24007'WA wtIEA T - FLCXJR lS COOKtO- FRESN' FRIEO 

lS003SA CANE SIJGAR 10 RAW'FRESII OR liFS 

25OO3SA CANE '""'" 21 COOK£O-NFS 

25OO3SA _ ...... 22 c()(x£o- FRES!HIAK£O 

2500lSA CANE SOGAA 31 COOKEO- FRESII OR WIlEO 

25""sa SUWUHIOlASSES 10 RAW-FleSH OR WFS """sa S:\.IGAA·MOlASseS 21 Cl)()(£.O-IfFS 

2SOQ3SS SI../GAJI-HOlASS£S 22 cooall- FRESH-BA~ 

25"''' SUGAA-ltC/lAsses 31 coot:;l:O'FItESM ~ CANIIEO 

2700"" COTTONSEED-OIL 18 PI«lCf:ssro OIL 

2100"" COTTOIIst:EO-QI L 18 PROCt::SstO OIL 

""0,"" COTTONSEED-MEAL 18 PROCESm:I OIL 

271lO31/A COTTONS£eo'IEAL 18 PROCESSED OIL " ..... UIME AIIO SKERlIY 10 jtW-FRESII Oft IIFS 

4305aAA UIKE AIIO SHERRY 21 COOt:EO-IiFS 

,-, 1'ItLK-tK»('fAT SOl.. 10 RAW-fRESII OR NFS 

'00000Il MtLX~MQN-fAT SOl 21 COOKED-HI'S 

5000<X>' KIL,,~WON'fAT SOt 51 COOKEl).CAHfm) 

50000fA MiLK-fAT SOlIOS 10 RAW'fRESH OR NFS 

50000fA MILK-FAT SOlIOS 21 COOKEO-NfS 

50000FA MILK-FAT SOliDS 51 C()()I(lD-CAWEO 

'OOOOSA MILK SUG (lPtCT) 21 COOk'EtI-HfS 

,- "1 LK SUG (tACT) 51 COOKEO·cAINED 

53OO1BA BEEF-MEAT BYP 21 COOKEO·IIFS 

53001BA BEEf-MfAT BYP 26 ~O·FR£SN-PICKLEO,CORNEP.OR CUREO 

5300188 BEEF-DTM ORGAJI 21 COOKED-liFS 

5300188 BEEf-DTH ORGAN 51 COOKEO·CAHttED 

53oo10A BEEf-DRIED 21 COJKEO-lIfS 

53001 FA &t:Ef-fAT 10 RAW'fRUII OR WI'S 

530011' A BEEf-fAT 21 COIXEO-IIFS 

53001fA 8EEF'fAT 22 COOKEn-FRESII'8AAEO 

530011' A BEEF'fAT 23 cooao·FRESII-BOILED 

530011' A UEF'fAT 24 COOKED-fRESH-BROILED 

5300lfA BEEf·fAT 25 coatEO·fRESH-fRIED 

53001KA BEEF-KIMT 21 COOKEll-lifS 

53001LA IlEU'LIVER 25 COOICED-fRESII-FRIEO 

53001LA SfEf-LIVER 31 ~'fRE$t( OR CAHH£D 

53001HA REf·LEAN 10 RMl- FRfSH OR IffS 

53001HA SfEf-lEAN 21 CClOkED-MFS 

53001'" UEF·LEAH 22 COOKED-FRESH'BAKEO 

• 

2F2711 P 2.000000 0._ 

IoF3142 P 0.100000 0.050000 

4F3142 P 0.100000 0.050000 

4F3142 P 0.100000 O.O'SOOOO 

4F3142 II' 0.100000 O.O'SOOOO 

4F3142 P 1.SOOOOO 0._ 

4F3142 P 1.500000 0._ 

4F3142 P 1.SOOOOO O.~OOOOOC 

4F3142 P 1.SOOOOO 0._ 

RERfG iii 2.000000 0 • ....,. 

OF2312 P 2.000000 0.048000 

REREG II 2.000000 0.3"'" 

OF2112 P 2.000000 0.398000 

9f217S P 8.000000 0.370000 

9f2178 P 8.000000 0.370000 

2F2T11 P 0.100000 0.100000 

2F2711 P 0.100000 0.100000 

2f2711 P 0.100000 0.100000 

2f2711 P 0.100000 O. tOOOOO 

2f2711 P 0.100000 0.100000 

2f2711 P 0.100000 0.100000 

2f2711 P 0.100000 0.100000 

2f2711 P 0_100000 0.100000 

2f2'711 P 0.11'JOOOO 0.100000 

2F2111 P 0.100000 0.100000 

2f2T11 P 0.100000 0.11lOOOO 

2f2711 P 0.100000 0.100000 

Zf2711 P 0,100000 0.100000 

2F2111 P 0.100000 0.100000 

2f2711 P 0.100000 0.100000 

2f2711 P 0.100000 0.100000 

2F2111 P 0.100000 0.100000 

2f2711 P 0.100000 0_100000 

2F2711 P 0.100000 0.100000 

2f2711 P 0.100000 0.100000 

2F2711 P 0.100000 0.100000 

2F2711 P 0.100000 O.lOOOOO 

2f2711 P 0.100000 0.100000 

2f2711 P 0.100000 0.100000 

2F2711 P 0_100000 0.100000 

• 

'.00 

,.00 

1.00 

1.00 

1.00 

1.00 

1.00 

1.00 

' 1.00 

21.00 

21.00 

21.00 

21.OQ 

1.00 

1.00 

100.00 

100,00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100,00 

100.00 

100.00 

100,00 

100_00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

0._ 0._ 0._ 0._ 

D.OOO5oo 

0."""" 

0.00400(1 

0.004000 

0.004000 

0.010000: 

0.0100s0 

O.063SSO 

0.083580 

1l.0259OO 

0.025900 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0_100000 

0.100000 

0.100000 

0.100000 

0.100000 

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ANTICIPATEO RESIOUE IMfOIItMATIOII FDA CAS1R;ll NlJMS£R 426A DATE: 10/14/94 

NOEL_ 

lEl'" 

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2:3 C()()!(fO~FR£SH~80IlEf) 

24 CXX»aaD~FR£SH~8ROll£O 

00 NOT SPEClFIEO (NO CONSUMPTION) 

00 MOT SPECIFIED (110 COW$OItPT1OM) 

23 COC«S:I-ftESH-80IlED 

2S ctlOKED~~-FIU£O 

00 MDT SPECIFIED (NO CON!\UIWTlOIO 

00 MOT $f'EC1F1EO (NO CONStJ:IWtlON) 

23 OOOKEO-fRESH~BOIlEf) 

25 ~·FR£StHRIEO 

00 NOT SPECfFIro (ItO CONSUMPTION) 

21 COClM:EO~IffS 

21 COOKaI-MFS 

21 COOKEO-NFS 

21 Cl:lOK£O-MFS 

00 NOT SPECIFIED (NO COWStlMPTlOIO 

21 CQOKEt)-NFS 

31 COOKED-FIfESH OR CAIiltEO 

21 CClOKEO-NFS 

21 CI'JOKEl)-MFS 

26 COOKEO~fRESlI·PlCl(lEll,COI!.MEtI,OR MEn 

10 RAW-FRESH 01 NFS 

21 coot:tll-MFS 

Z3 coot;ED~FItESM~801Lel) 

2S COOICED-AtfStHltlEO 

Z6 COOKED-FJt£SII·Pla::leO,COfIMED,OR MEn 

21 et:lIXID-NFS 

21 COOKED-MFS 

25 ~~'ItESH-FR1ED 

21 COOKED-IIFS 

25 coot:ED-FRESK~FR1EI) 

26 COOKEO~'RESM-PICk1EO,~IIEO.OR CUReo 

21 COOICED-MFS 

26 000kE0-FJt£SII-P1CKlED,CORMeD,0R CUR£O 

2:1 COClKEO-"FS 

25 ~-FRES"-FRIEf) 

21 et::tteD-MFS 

31 COOKSHItfSM OR CAMIf£O 

62 CXIOI(S)-FRfSM OR fROZEIHwceo 

21 too;;:eo-MFS 

• 

TOlERANCE AATlC1PATED 

PET.# (ppmI) RESIDUE (ppm) AR STATISTIC TTPE " ~ T!tEAT£t) 

2f2711 

2F2:711 

2F271 I 

2F2111 

2f2711 

2F2711 

2F2711 

2F2711 

2f271t 

2F2711 

2f2711 

2f2711 

2F2Tl1 

lF27t1 . 2F2711 

2F27t1 

2F2711 

2F2711 

2Fl711 

2F2711 

2f211t 

2f2711 

2F211t 

2F2711 

2F271t 

2F2Tt1 

2F2711 

2f2711 

2F2711 

2F2711 

2f2Tll 

2f2711 

NOTO!. 

NOTOI. 

1IOT0l 

NOTOl 

NOTOi. 

NOTOi. 

NOTOi. 

IIOTIi. 

P 0.100000 

p o~ 100000 

P 0~100000 

P 0.100000 

P 0.100000 

P 0.100000 

P 0.100000 

p O. tooooo 

P 0.100000 

P 0.100000 

P 0.100000 

p 0.100000 

P 0.100000 

P 0.100000 

P O. tOOOOO 

P 0.100000 

P O. tOOOOO 

P O. tOOOOO 

P 0.100000 

P 0.100000 

P o~ 100000 

P O~ 100000 

P 0.100000 

P 0.100000 

P 0.100000 

P 0.100000 

P O. tOOOOO 

p 0.100000 

P 0.100000 

P 0.100000 

p o. tOOOOO 

P O. tOODOO 

A 0.008000 

A 0.008000 

A 0.015000 

A O.Ot5OOO 

A O.OOtooo 

A 0.001000 

A 0.001000 

A 0.008000 

0.100000 

0.10000D 

0.100000 

0.100000 

O. 1 (NJ(JC)O 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.11JOOOO 

0.100000 

0.100000 

0.100000 

01100000 

O. tooooo 

O. tOOOOO 0._ 0._ 

0.0t5000 

0.015000 

0.001000 

0.001000 

o.ootooo 

0.008000 

'''',' 

•• t,;>", 

,~"4;{i,bful > , ,if.lf!!lf 

too,oo 

tOO.OO 

100,00 

100,00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

100.00 

tOO,OO 

too.oo 

too.oo 

100.00 

100.00 

100.00 

tOO.OO 

100.00 

100.00 

100.00 

100.00 

too.OO 

100.00 

too.OO 

100.00 

100.00 

100.00 

100.00 

PAGE: 5 

RES. VAlUE US£t) 

1M TAS RUN (ppm) 

0.100000 

0.100000 

0_100000 

0.100000 

0~100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

0.100000 

O~ 100000 

0.100000 

0.100000 

0.100000 

0.100000 

O~ 100000 

O. tOOOOO 

0.100000 

0.100000 

0.100000 

0.100000 

O. tOOOOO 

0.100000 

o. tOOOOO 

0.100000 

0.100000 

0.100000 

D. tOOOOO 0._ 0."""'" 

0.015000 

0.015000 

0.001000 

0.001000 

0.001000 0._ 

<0 

<0 

...-
--- ~----~--- .. 

-.',' •• ii. >C. ~:~", "~, ' 

• 

• H 

88888gggg8888SS88SggggSggS8888 i 

888888888888888888888888888888 ~. 1-_-, 

ii 

167 

~ .............. ~~.~~~~~~~- --------
1f\t\U; ~ ':',"l,' I 

TOlE1VJtCE ASS£SSfIIENT nSTDf MVTIIfE CHltONIC ANAlTStS 

~19N SU8§fWL!' 

U.S>P6Puu.TlON • 42 STAns , 

u.s: P'bPUt.AilOH • SPRlitG $EASON 

U.s" 'fOPUlATtOH - SlJMMER $£ASCII 

U.S_' POPUU.TlOH - fAll SfAStlM 

u.S,_tPOflUtATIOM - WINTER SEASON 

_!EAST HSIOH 

~:A;aCTUL REGION 

~1tE:GION 

~REGI,* 

..... .!..ts ~.J~IC WHtTES 

~MISPANIC BLACKS 

JION-IiISPANtC OTHERS 

lEl= 

NURSJNG INFAMY$ « t YEAR Oll)} 

JDHMtS)WG INFAHTS « 1 YEAR 0Ul) 

fEMt'ES (11+ TEAlS, PREGAAMT) 

FEMia 13+ YEAAS, HURSlltG 

C1II,101WI (1-6 YEARS 01.0) 

CNIJ.D!tEN (7-12 YEARS 0Ul) 

~ (t3-t9 TEARS OlD) 

FaW.!S (13-19 YEARS (JUl, HOT P1{EG. OR HORSING) 

KM,ES (20 YWS ANI) OI.OEIU 

fEMALES (20 TEARS AND OlDER, HOT PItEG. OR NORS) 

, ,j' 

TOTAL THII:C (HG/KG BOOT WEIGItT/OAY> 

MRC* !!i!! -- 0.014716 0.015<883 ... "..,. 6.485667 

0.0135T9 -0.014481 80.448394 5.340733 

0.014228 0.015238 84.6>8033 5.6tt139 

0.015262 O.Ot6493 9t.6303S6 6.842589 

0.01'SO$O 0.016547 ~.92nll 8.152539 

0.016574 0.018254 101.410311 9.331094 

0.014273 0.014950 83.053583 3;T60989 

0.oH182 .0.Ot2737 70.7609'/'8 5.303267 

O.Ot6872 0.018436 102.422283 8.691117 

0.015396 0_01668t 92.669922 1.126239 

0.015103 0.016309 ' 90.604100' 6.7013t1 

0.010414 '0.011290 62.721150 4.865728 

0.0140t7 0.Ot5066 83.698683 5.826917 

0.027759 0.040356 224. tge822 69.984128 

0.04&403 0.06S7'57 365.314994 96.409394 

0.010654 0.011094 61.631050 2:.44l422: 

0.013584 0.Ot4373 79.851228 '.3823B9 

0.035Q7 0.040S11 225.060933 ZII.Z<2289 

0.020924 0.021999 122.2t5672 5.96886t 

0.012740 0.013261 73.6702t1 2 •• 522 

0.010992 0.011562 64.233450 ,0 3.166561 

0.Ot0542 O.ot09OS 6O.S8S306 2.020918 

0.010170 0.010619 58.993544 2.4mp6 

, "'Current TMR't does. J»t tnctude nw or pending tote1"ancec • .... New nmc inctudes nMf, piH'lding. end pubt lshed tolef'lltlC9$ • 

• • 

DATE: 10/14/910 ..... , 

EFfECT OF ANTICIPATED RESIDUES 

0.OOt624 

0.001521 

0.001654 

0.001670 

0.OOt6Sl) 

O.oot766 

0.00164t 

0.001382 

0.001826 

O.OOt970 

0.001639 

0.001346 

0.001'786 

0.00l1'69 

O.OO878t 

O.OO1t42 

0.001483 0."""" 

0.002619 

0.oot649 

O.OOl3Z2 

O.IlOCI903 

0.00092' 

9.02465 

8.45-096 

9.188S0 

9.27'9t1 

9.16&94 

9.81122 

9.11759 

7.67868 

10.144Z7 

10.94525 

9. urns 

7.41951 

9.91%6 

t5.38102 

4S.7806;! 

6.34570 

8.23956 

24.49352 

14.55129 

9. """ 7.3-\266 

S ...... 

5. t35a8 

co 

(0 

...-
; 

TOlERANCE ASSES_HT SUl!MAAY FOR Eth~¢O 

USING AHTTCIPATeO RESIDUES 

CASUElL tl426A 

DATE: 10/18/94 

AHAlYSIS fOIl: POPUlATlOH stJa~GJWlJP: U.S. POPULATION ~ 48 STATES 

EXISTING ANTICIPATED IIESIPIJE$ (MLISKED ONLY) 

-

RESULT IN AN ARC OF: 0.001572 Me/KG/DAY 

THE EXISTING ARC IS EOUIVALENT TO! 8.733 "Of TilE ADI. 

PROI'O«O HEY ANTIC I PAlEO RESIOUES (CURRENT PET! T IOff OHl y) 

RESULT IN AN ARC Of: 0.000034 MG/KG/DAY 

TIiESf NE\J ANTICIPATE!) RESIDUES Will OCCUPY: 0.191 X Of THE ADI. 

If TilE HEY ANTICIPATEO RESIDUES (CURRENT PEtiTION ONLY) 

ARE APPROYfD TII£ RESUlTANT Me \llll BE: 0.001606 I«i/KG/DAY 

TKE NEY ARC Will OCC'Uf'Y 8.924 X OF THE ADI. 

OTIIER PENDING ANTICIPATEO RESIOUES EXCLUDING TilE 

OJRREIfT NEil PETITIOH KAVE AN ARC OF: 0.000018 ltG/KG/DAY 

TillS ARC Will occupy 0.101 X Of TtlE AOI • 

• IF ALL PEHOING ANTICIPATED RESIDUES (INCLUDING TilE 

CURRENT NEW PETITION) ARE GRANTED 

• 

THE RESUlTAHT ARC Uill BE: 0.001624 MG/KG/DAY 

TItE TOTAL,~RC \I(ll occupy 9.D25 % Of TilE ADI. 

AIlALYSIS fOR POPULATION sua-GlWUP: NON-ituRSING INFANTS « 1 YEAl!: OlD) 

EXISTING ANTICIPATEO RESIDUES (PUllISKED ONLY) 

RESUlT IW AN ARC Of: D.008227 HG/ICGJI)AY 

TKE EXISTING ARC IS EQUIVALENT TO: 45.704 "Of TilE ADT. 

PROPOSEO NEW ANTICIPATED RESIDUES (CURRENT PETITION ONLY) 

RESULT IN AN ARC OF: 0.000533 HC/KG/DAY 

THESE NE\I AIUlCIPATED RESIOUES \llll occupy: 2.962 X Of TilE ADI. 

IF TilE HE\I ANTIClPATED RESIDUES (CURRENT PETITION ONLY) 

ARE APPROVED THE RESUlTAMT ARC I./Ill BE: 0.008760 HG!KG/DAY 

TilE NE\I ARC \lILL ocCUPY 48.667 "Of TilE ADI. 

OTIfER PENDING ANTICIPATED RESIDUES EXCLUDING TKE 

CURRENT NEW PETITIoN KAW All AlI.C DF:' 0.000021 MG/KG/OAY 

TillS ARC WilL occupy 0.114 "Of TKE ADI • 

If All PEnDING AHTICIPAlED RE$lOUES (INClUD1NG TKE 

CUIUIENl,itE\aETlTIOto AAE GRANTED 

TilE RESUlTANT ARC wIll liE: D.008781 MG/KG/DAY 

HIE TOYAl ARe lULt. occupy 48.781 X OF TRr ADI. 

ANALYSIS fOR POPULATION sua-GROUP: C"llDREN (1~6 YEARS OlD) 

EXISTING ANTICIPATEO RESIDUES (PUBlISIiED OHlY) 

RESULT IN AN ARC Of: ' 0.004216 MG/KG/DAY 

TilE EXISTING ARC IS EtXJlVAlEWI TO: 23.420 X Of TilE AOI. 

PROPOSEO HE\I ANTICIPATED RESIDUES (CURRENT PETITIOH OHlY) 

RESULT I N AN Al!:C OF: D ;000153 MGjKG/DAY 

TIiESf NEW ANT lelPATED RESIDUES \llll OCCUPY: 0.852" Of TilE ADI. 

If TilE NE\I ANlIC}PATEO RESIDUES (CURRENT PETITION OtoiLY) 

ARE APPRQVEt) TNE RESUlTAItT ARC \llll BE: 0.004l69 MIl/KC/OAY 

IHE NEW ARC \JIll OCCUPY 24.2n "Of THE ADI. 

OTIIER PENDING ANTICIPATeD RESIDUES EXCLUOING TNE 

CURREIlT HE\I PETITIO# HAVE AN ARC OF: D.000040 MG/KG/DAY 

TillS ARC \lILL occupy D.221 ox Of TilE ADI. 

IF ALL PENDING ANTlCIPATED RESID\J£S (lHClutJING TilE 

CURRENT N£\I PETITION) AR:/! GRANTED 

TilE RESULTANT ARC \lILL BE: D.DG4409 MG/KG/DAY 

THE TOTAL ARC \lILL OCCUflY 24.'94 :t. Of TilE ADI. 

169 ..~ 
'. 

'M)..f a.. 

TOlERAMcr ASSfSSMEMT 5tsJ'EM ROUTINE CtIltotHC ANALYSIS 

-, '# 

"> 

0.00 PC* 

l£L_ 1.8000 -sit, 

0.00 

:0; lll!l'll E UfO 

, ,~ , lOTAl. TMRC (MG/J:Q BOOY WEIGHT/OAYl 

~!l0!I """"'" CtJRItEMT TMRC'" NEW TMRC** 

U:$~,:}IOfIOU.TlOH • 48 STATES 0.014253 0.015420 

U.$~ '~TlON - SPltUfG S!A$ON 0.013113 0.01401S 

U.S.' P!:IPULATfON - SUHMER SEASON 0.013640 O.0146SO 

U.S. POPlUTIOM " FALl. SOSON 0.014$13' 0.016044 

U.S.,POPIJt.ATlOlf - WINTER stAso. 0.014670 0.016138 

NOII:~Sl REGIa. 0.015909 0.017588 

tIORtti taTRAl Rt:GION 0.013869 0.014546 

SOlItIERW REGIOH 0.011476 0.012431 

WESTaut REG10N 0.016323 0.017881 

Hl~~'lics 0.015108 0.016390 NON~MrSPAM1C WHITES 0.0145&9 ' O.0151'9ti 

**~K1spAlnC 8lACKS 0.010178 0.0110$4 

14OH~"t$YAN1C OT}l£RS 0.013683 0.014731 

~fB INFANTS « 1 YEAR OlD) O.02nn 0.039868 

)Qt-MSUm UIFAIflS « 1 lEAR OlD) 0 ....... 0.064043 feW.u (13i" YEMS. PREGlMHT) 0.010404 0.010!!4' 

'~$ 13+ YEARS, fllJR'SJI4G 0.013113 0.01391)2 

ctlll.iJft£N <1-6 Y£ARS OlO) 0.034559 O.1l39643 

CMllbRfN (7-12 YEARS 01..0, D."""'" 0.021500 ~ (13-19 YEARS OUt' 0.012496 0.013011 

fEMALES (13-19 YEARS OlD, NOT nEG. OR NUIISIMG) 0.010647 0.011217 

tW.ES' (2'0 'fURS AND OlDER) 0.010201 0.010565 

fatAl.!:S (20 YEARS MIO OlDER, HOT Jt1i:EG. OR M\JRS) 0.009703 0.010151 

.... AS PERtaiT -

Of 'FO 

85.666406 

78.192489 

81.38S'&94 

89.13'5300 

89.653528 

97.111761 

80.812483 

... 0S97'J4 

99.371683 

91.056944 

81.753628 

61.40e950 

81.841500 

221.490161 

355.1'94361 

60.245367 

17.232t!03 

220.137S83 

119.444861 

72.315922 

Q.3t8311 

58.69S0 

56.396100 

.. 

Dtff'a!SICE 

AS PIIK:£NY 

OflFO 

6.~7 

1.:$40733 

5.611139 

........ 

•• 152539 

9~331tw4 3.-

5.303267 

8.691117 

7.1l6239 

6.701311 

4.865128 

5.826911 

69,984128 96._ 

2.~2 4._ 

.:.a. ...... 

5.968861 

2.894522 ,~. 3. U6S61 

' ,2.020978 

2.492606 

*ClJrrent llIItt does Mt ini:tude new or pendfl19 toleranctil • ...... M$t TMRC Inclu::1&5 MIl, pending, fit'Id pWlfflhed tolerance. • 

'": 

, • • 

, 

DATE: 10/14/9<0 PAGE: 

EFFEct Of ANTICIPATED RESlDOES 

ARC " .. 0.001553 8.62621 

0.001459 8.10745 

0.001538 8.54595 

0.001610 8.94443 

0.001601 8.89502 

0.001652 9.17681 

O.OO1~ 8.79891 

0.001344 7.46932 

0.001732 9.61963 

0.001921 10.67066 

D.001551 8.65128 

0.001325 7.36334 

o.com:. 9.517Q2 

O.00Z661 14.78433 

0.008427 46.81897 

0.001092: •• 061191 

0.001389 1.71664 

0.00W3 2:3.~1Z3 

0.002555 14.19619 

0.001620 9.00122 

0.0012711 1.05538 

0.000936 5.20041 

0.D00S46 4.69887 

o 

I"-

..-
• 

• 

I, Cynthia L. Giles-Parker, Product Manager, Fungicide-Herbicide 

Branch, Registration Division, Office of Prevention, Pesticides and 

Toxic Substances, U.S. Environmental Protection Agency, do hereby 

certify that the pesticide product listed below is currently 

registered with this Agency under the Federal Insecticide, 

Fungicide, and Rodenticide Act, as amended. that the label attached 

is a true, correct, and compared copy of the correspondence of 

record, and that the product may be sold and marketed in the United 

States of America for the uses indicated on the label. 

The product registration listed below has been issued to: 

Rhone-Poulenc Ag Company . P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, North Carolina 27709 

EPA Registration Name of Product 

264-418 CERONE 

IN WITNESS WHEREOF I have hereunto 

set my hand and affixed the seal of 

the U.S. ENVIRONMENTAL PROTECTION AGENCY 

this ~ day of £f'('1 A.D. 1994 

Cynthia L. Giles-Parker 

Product Manager #22 

Fungicide-Herbicide Branch 

Registration Division (7505C) 

171 
r 

~ RHONE-POULENC_ 

.. 

RHONE-POUlENC AG COMPANY 

Septermer7,1994 

Ms. Cynthia Giles-Parker 

OffiCe of Pesticide Programs (H7505C) 

Document Processing Desk (CERn 

u.s. Envlronmenlal Protection Agency 

Room 266A, Crystal Mall 2 

1921 Jefferson Davis Highway 

Arlington, Virginia 22202 

Dear Ms. Giles-Parker: 

Re: CERONE® 720, EPA Reg. No.: 264·418 

Please provide us with five (5) certificates of registration for the product relerenced above. Please include Ihe 

following information on each certificate: 

(1). Registrant: 

(2). Name 01 lhe Product: 

Rhone-Poulenc Ag COmpany 

P.O. Box 12014. 2 T. W. Alexander Drive 

Research Triangle Park, North Carolina 27709 

CERONE® 720. EPA Reg. No. 264-418 

(3). The phrase wUhjn the body of the paragraph: ~ .. .that Ihe produc1 may be sold and marketed in the 

UnUed States for the uses indicated on Ihe fabel.~ 

CIt Please conI act me at (919) 549·2122 should you have any questions ~garcnng th'ls request. 

Sinc~Hely, 

:~/-&&ft[o (~ilHurSey ~egjstralion Documents Specialist 

• • • • • •••• 

• 

•• 

• 

• 

• •• 

• • •••• 

. ' .. .. .. 

•••••• 

• • 

• ••••• 

• • • ... • • • •• • • 

..... ' 

• • •• 

•••• • • • •• 

YO BOX '2D!4 ]' i ',',' !'lV,A"'~;Lf1 DR--,-", 

"ESEAR;::), iR'_"'WiLt: i-'/II'!"- he ;!"!J:) 

:'JIJIS49-?W(l 

!N7El';},AliGN-",L 1f; H f>L:!IBrH 4'f'-'~.F" -_,","',','1 "i."S,,- A~( ;;'r· 

Excoifenco Hl Perlorm?flCe 

Pnde In AchJCllcme-nr 

HleAt,AfIOh':'1 cLsrmfJl; 1'01-1 Sf I'V,U:S 'c- ~Ll ~,,_I"(JLI" ~,",)}jr{" ,\LSW~f-!,\!\:~r_ Ai-'; __ C~ 

172 ~-~~ .. - ._------------------
UNITED STATBS ENVIRONMENTAL PROTECTION AGENCY 

Office of Pesticide Programs 

Registration Division 

, _ ',("'?/J iLl"' ~ 

Warren A Davis 

RHONE-POULENC AG COMPANY 

BOX 12014 

RESEARCH TRIANGLE PARK Ne 27709 

Subject: Label Amendment Submission of 06/28/93 

to Comply with WPS Labeling Requirements 

EPA Reg Nr. 264-418 

PREP PLANT REGULATOR FOR COTTON 

e Dear Registrant: 

• 

The labeling cited above and submitted in connection 

with registration under the Federal Insecticide, Fungicide, 

and Rodenticide Act, as amended, is accepted subject to the 

comments listed below. 

Based on your certification, the Agency has accepted 

only those changes to your labeling which are necessary to 

comply with PR Notices 93-7 and 93-11, which reflect the WPS 

labeling requirements of 40 CFR part 156, subpart K. Any 

other labeling changes submitted in connection with this 

amendment application and not directly related to compliance 

with PR Notice 93·7 or 93·11 have neither been reviewed nor 

accepted by the Agency. If you wish to make any such 

changes, you must submit a separate amendment application 

proposing them. If your product registration is currently 

suspended, acceptance of this labeling amendment does not 

affect the suspension in any way. 

A copy of your proposed labeling stamped, "Accepted with 

comments", is attached. Make any required changes described 

below and send three copies of final labeling as soon as it 

is available to: 

Document Processing Desk (FIN-LABEL) 

Office of Pesticide Programs (H-7504C) 

u.s. Environmental Protection Agency 

401 M Street, SW 

Washington, DC 20460·0001 

173 
RHONE-POULENC AG COMPANY 

EPA Reg. Number. 264-418 

PREP PLANT REGULATOR FOR COTTON 

Application date. 06/28/93 

Original Submission 

• 

• 

Hand or courier deliveries of final labels may be made to: 

Document processing Desk (FIN-LABEL) 

Room 266A, Crystal Mall 2 

1921 Jefferson Davis Highway 

Arlington, VA 22202 

You have not transcribed the first paragraph in the 

Agricultural Use Requirements section exactly as prescribed 

in the Main Labeling Guidance . 

There is a typographical error(s) in the PPE statements that 

you added to the Precautionary Statements. 

There is a typographical error(s) in the Spanish language 

text. 

Please correct the typographical errors circled on the 

draft before printing final labeling. 

In your final labeling, the UAgricultural Use 

Reguirements R text must be contained in a clearly separate 

box. This box may be set apart by a line, by another 

graphical device, by a different color background, or in any 

other way that clearly distinguishes it from surrounding 

text . 

\ 

incerely, 

r:J 

g~atii/support Branch 

egistrat10n DivIsion 

174 ...................•.••......•.•. ~~~~~~~~~~-
Admin; 264 -418 

Analyst comments: 

TypO in F-2: replace the word "expectations" with the word "exceptions". 

Add to apron statement in PPE "mixing, or loading" . 

• 

• 

175 
ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: E1hephon (2-Chloroethyl) phosphonlc acid" ........................................ 55.4% 

INERT INGREDIENTS: ........................................................ . , ................. ., ..... ., ...... " ..................... 44.6% 

"This product contains 6 pounds elhephon per gallon. 

EPA Reg. No. 264·418 EPA Est. No. 264·PA·01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

Si usled no entionde fa etiquotu. busque;a aiguion p'il:i'a quo so fa expliquo a usloo en dotaJlo. 

(If you do not understand Iho laboWindJ!Ofnoone 10 explain illo you in detail) 

For MEDICAL And TRANSPORTATION EmergencIes ONLY Call 24 Hours A Day 18 800-334-7577 

For ~ InformaUon Call 1-800-334-9745 

Tho use of fhis producl or a varioly of planl growth regulation uses are proloctod by United lales and foreign pafonls including 

• 

U.S. Patents 38.791,188 and 4,240,B 19, No liconse Is granlod 10 use this product in counlries other Ihan tho United Sialos or for any 

use not contemplaled by this label. Liability lor palent infringement may result from use or sale of this product outside Ihe United 

Siaies. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold oyolids open and lIush with a g6nllo stream 01 water lor at loast 15 minuto$, Get medical allenlion. prolorably an 

ophthalmologist 

IF ON SKIN: Immedialely wash skin with plenty of soap and water. 

IF SWALLOWED: Do not induce vomiting. Promptly drink a targQ quantity 01 milk, egg whitos. gelalin solution or il these are nol 

ayailable, drink large quantkies 01 wator. AYoid alcohol. Call a physician immediamly. 

IF INHALED: Remove victim to frosh air. If nol brosthing. give arrilicial respiration. Adminisler oxygen if necesalitV;:t'~)medical 

attenlion. "fi!lJ C(IMMK:ffS rll n',' t~lI .. r OMNl 

PRECAUTIONARY STATEMENTS 

DANGER t;, ... 1t:r II>" ~\·Jcr"t t,.,,,wtldd,,. 

F'untlidd<:. m,,1 Ro<I,mtld.t" Act 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS " M,rndd. '"' u," ..... "dM 

•

CORROSIVE. Causes eye and skin damage. May be fatal if absorbed through skin. Harmlul if swalioweBS __ lWI_' ~~.!..JdW'U.~%~;);.#ill1-L'''-'~_.\\,_ih'9~':..'· pray miSI. 00 not gol in eyos, on skin or on clothing. Keop away from domestic animals, ~ -~ 

NOTE TO PHYSICIAN 

Thero is no spocific anlidote. All trealment should be based 011 observed signs and symploms of distress in the patient. Overexposure 

10 malerials olher than this product may have occurred. 

Victims 01 seyere overexposure, by inhalation, shOUld bo kopt under modical observation lor up to 72 hours for dolayed onsal of 

pulmonary edema. In a victim 01 oyer·exposure by ingestion, carelul gastric lavago is required due to tho possibility 01 slomach or 

esophagoal porforation. This material is an acid, but use of alkaline subslances to neutralize it is contraindicated. 

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicalors and other handlers musl wear coyeraUs ovor short-sleeYod shins and shon panlS, waterprool gloves, chemical-resy,lant 

foolwear plus socks, protective eyewear, chemical· resistant headgear lor overhead exposure and chemical-resislanl aprorywhe!)) 

cleaning euipmenl. L/ 

Discard clOlhing and olhor absorbed malerials Ihal have been drenched or heaY·lly contaminatod with this producfs concenlrale. Do 

nol reuse Ihem. Follow manufacturer's instruclionslor cloaning/maintaining PPE. II no such instruclions lor washables, use detergent 

and hoi water. Keep and wash PPE separately lrom othor laundry. 

When handlers use closed systems, enclosed cabs, or aircrah in a manner thai meets the requirements lisled In Ihe Worker PrOleclion 

Standard (WPS) for agricultural pesticides {40 CFR t70.240 (d) (4-6)J, the handler PPE requirements may be reduced or modified as 

specilied in the WPS, 

User Safety Recommendations 

Users should wash hands beloH) eating, drinking, chewing gum. using tobacco or using Ihe loitel. 

Remoye clothina immedialely il pesticide aets inside. Then wash body thoroughly and out on clean dothing, 

176 
--- --~----- -----~-~--------

ENVIRONMENTAL HAZARDS 

For terrestrial uses, do not apply directly to water, or 10 areas WhtH9 surfaC(! water is present or to intertidal areas below the mean high 

water mark. Do not contaminate water whon disposing of equipment washwaters. 

00 not contaminate water used for irrigation or domestic purposes. 

USE PRECAUTIONS 

Do not apply PREP'»' brand Ethephon through any type of irrigation system. 

Avoid spray drift to nearby crops as this product will cause modifications in plan! growth. Ptan! injury or reduced yields will result. 

Do not plan! another crop within 30 days after treat men!. 

Mix only the amount of spray you expect 10 use Gach day_ Do not allow mixed solution to stand overnight. 

DIRECTIONS FOR USE 

It Is a VIolation of Federal Law to use thIs product In a manner Inconatstent wIth tts labeHng. 

Read entire label before usIng thIs product. 

Do not apply this product in a way that will contact workers or other parsons, either directly or through drift. Only protOCled handlers 

milY be in the area during application. For any requiromenls specilic to your Stato or Tribo, consult the agoncy responsible lor 

posticide regulations. 

this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR part 170. ThIs slandard contains 

i for the prolection 01 agricultural workors on farms, forests, nurseries, and greenhousos, and handlers of 

tt contains requirements for training, doconlamination, notification, and emergency assistance. It also 

and expectations partaining to tho stalemonts on this label about personal protective equipment (PPE), 

and restricted·entry intervals. The roquiremonls in Ihis box only appfy 10 uses of this product that arc covered by the 

Standard. 

1Il0 001 enter or anow worker entry inlO treated areas during the restricted·entry inlerval (REI) of 48 hours. 

roquirod for early entry to trGatod arGas thnt is permitted under tho Worker Protection Standard and that involves conlact 

i that has beon traa1ed such as plants. sailor water is coveralls OVor short-sloeved shirt and short pants, waterproof ,"'"0-, 1 

footwear plus socks, protective eyowoar and chemical-rosistant headgear for overhead exposure. 

II 

not contaminate water, food. or food by storage or disposal. 

conlainer is broken or contents have spi!lod, follow all prqcaulions indicatod above and dean up immediately, Belore cleaning up, 

full longlh trousors, long Sloeved shirt, protective gloves, and goggles or face shield, Soak up spill with absorbent media such 

sand, earth or other suitabfe material and dispose of waste at an approvod wasle disposal facility. 

l~:~,~~:~~"~;, DISPOSAL I! wastes are ncutaly hazardous. Improper disposal 01 oxcess pesticide, spray mixture, or rinsate is a Violation 01 FedGral law. 

these wastes cannot be disposed of by use according to label Instructions, contact your State Pesllc/de or Environmental Control 

I"'""cvorlh. Hazardous Waste representativo at the noarest EPA Rogional Office for guidance. 

NER DISPOSAL 

I I I the empty conlainers. ollor for in a sanitary 

ill, i 

GENERAL INFORMATION 

COTTON 

A fonar spray of PREpm brand Ethephon will accehm\le opening of maturo unop&ned cotton bolls and onhance defoliation whkh can 

result in earlier harvest wifh an increased recoverable yield. PREP1~ brand Elhaphon treatment on cotton allows increased efficiency 

from a once-over harvost. 

TOBACCO (FLUE·CURED): A foliar spray 01 PREpr>.! brand Ethephon promotes early, uniform flyollowin~f of maturo tobacco. 

PREPTM roducss curing timo, allowing mom ellident use of curing barn spaco, and increased control over harvesl schedules, 

SPRA Y PREPARATION 

Add 112 1031401 the required amount of water to the spray lank. Start agitation. Add tile required amount of PREPI'M brand Ethephon, 

and the remaining amount of water. Prepare only as much spray solution as can be used on the day of mixing, Do not allow spray 

solulion to stand overnight. Do not spill the concenlratod produci on spray equipment, or any airplane parts. 

177 
--------------_.------.- - --- .. 

ANY SPILLS SHOULD BE RINSED lMMEDJATEl Y WITH PlENlY OF WATER. 

Use of a nurse lank is highly recommendod lor avoiding possible spills of conconHaled lormulalion on spray equipment or any airplano 

parts. 

TANK MIXTURES WITH DEFOlfANTS AND INSECTfCIDES 

PREpm brand Ethephon is compatible with OEFl, FOLEXS:, Drapp?, Harvade3. Melhyl Paralhion, Guthionr, and Malalhion4. PREprn 

may bo appliod in sequence or as a lank mi:duro (00 NOT TANK MIX WITH DESICCANTS IF COTTON IS TO BE SPINDLE 

HARVESTED). Follow all applicable use precautions and rate per acre rfXX)mmondalions 01'\ labels of products applied as tank mixlur(lS 

or in sequence with PREP TIl brand Ethephon, In some cases sligh! reduction in boll oponing response has been observed when lank 

mixos with defollanls wore ullod. 

Good agitation in th& spray tank is essenllal and a tank mh:ture should not be allowod to stand wilhout agitation lor more than 5to to 

minutes. Read and ObsOrY(1 all appropriate label use directions and precautions for the dofollants and insoCliddes usod. 

NOTE: UndGr certain conditions, tank mixturos of PREpnI brand Ethephon wilh desiccants containing sodium chlorate could 

result in the formation of hypochlorous acids which on heating will emit toxic chloride fumes. 

EQUIPMENT CLEANING 

Because of the acidic naturo of this product, prolonged oxposuro to spray doposit will damage acrylic plaslics, certain paints, and 

metals, 

Rinse thoroughly with a detergent and water al! o:.:posoo acrylic plastic-type materials (o.g., aircraft windshields), and painted surfacos 

within an hour alter exposure to spray deposits, 

At the end of each day, rinse thoroughly With a detorgent and water all Ihc metal paris of tho aircral! and the assodated spray tID equipment o:.:posod to the spray deposits . 

• 

178 
COTTON 

EXPECTED PREpTM ONE SPRAY VOLUME APPLICATION 

USE CONDITIONS RATE GALLON (Gats/A) TIMING 

PREpnt 

DI ,. LBS A,t. Acr •• "Ir" 

PREP'N Hot and dry aO°F or tt/3 1,0 6 Apply whon the number C?f 

Boll Opener· highor mafure unoponed bolls. is 

Dry and 75 to 80cF 2 1.5 , \5-50 2,5 sufliciont to produce t~~ desired crop. See belOW,-for 

Coo! but above 65cF 2213 2,0 3 tost of boll maturity. 

Treatment uniformly opens or bolls 710 14days oarlior. 1o, "'" 

PAEPt\I + High soil moisture 113 0.25 24 15-SO 5· 10 Apply 4 to 7 days p~jor. to 

FOLEX* 0' PREP?!.! boll 

Defoliant Tank High Il!rlilily levol r i Tobe j •. ~s 

Mix or I a ~ I treafmen::,,:lt~: 

1o, ~ff, 

nol i~ pl~c •. of PREP" "",i 

-. .,.. Dropp2 High soil moisturo 1/3 0.25 24 to-So 3 - to I Apply 4 to 7 days prior to 

Oefollant Tank High IQrlility lavel boll oponing 

Mix . To bo usod as 

Rank colton i s' :_PI~~;_,froalmGnt W~h, i ~~t i~ 01 PREpm bon , Pre-CondItioner Hot, dry. 2/3 0.5 12 Apply 4 to 7 days prior to 

lor Defoliation Coot, above $5cF t ti3 1.0 6 t5-50 2-5 detoliant. Enhances._~~~ 

or crop defonation reducing 

deterioration of bollom crop 

Rank cotton .od allows lor earlier 

·pretreatment With Defoliants Prior to PREP'fM Boll Opening Treatment 

tt the cotton Is overly rank or taying down in tho mlddfes and good spray cowHage at tho bolts with PREPTl.4 is difficult, a pmtroatmont 

w~h defoliants witt be uselul to Improve borr coverage with PREP''', Use dosage rates 01 PREpnl brand Ethephon recommended for boH 

opening. Road and obsorve all appropriate tabal usa dIrections and precaulions for tho dofotiant used. 

·'fn California and Arizona use a votume of no fess than 5 gallons per acre for aerial applications. _011 Maturity 

A boH is mature when it is too hard to be danta<:! when squeezoo between thumb and fingers, too hard to be sticod with a sharp knijo, and 

when the seed coat becomes tight brown in coior. 

Use LImitations 

Do not excuod a maximum of 2,0 Ib, altA torcomblnod uses at PREpni per acro peryear. 

Bolt Oponing: 00 not tank mix PREP'N brand Ethophon with a desiccant it the cotton is to be spindte harvosted. 

Pro-Condition for Defoliation: 00 not tank mix PREplM with desiccants untoss ptnnt desiccation is required. Do not use a dolotiant 

belore thero is sufticient mature unopened bolts to produce the dosired yiold (soe Generat tnformation s(!(;tion on how to test for bolt 

maturity. 

WHEN TO HARVEST COTTON 

Do not harvost cotton sooner than 7 days after a troatment with PREp'~ bland Ethephon. 

Obsarva the treated crop and harvest whon optimum bolt opening has boen reached. 100 earty harvest might reduco the full advantago 

01 the treatment and tOO tate a harvest may result in reducod quality and toss of tint which wiUdrop tram the plant. 

179 
PREpt'>I .Spray 

Crop Pints/Acre 

Ac<o 

Dir9Ctod Spray 1 tl3 50 ·60 

Application 

OVot-Tha·Top 1113-2213 40-60 

Application 

USE LIMITATfONS 

TOBACCO 

(Flue-Cured Only) 

SpecIfic Directions 

Use drop nozztes. Choose TG or OC spray tips designed 10 apply 50 • 60 

gpa at 35·40 psi aod at tracfor speed of 2-3 mph. Us. 

2 nozzles per row; one on each side of fhe rowdropp4}d low enough to direct 

the spray 10 IhD lDavos to bo riponod and harvested. Thorough spray 

is essential. Wilh a directod spray, bfJ sure to harvest aU leavos 

'mo" I 

Treaf only when leavGS remaining on the sfalk are mafure, To ensura 

romafnlng leaves are mature. test spray several lobacco plants as 

described under the soetion ·Proper Time of Treatment" Use tho lower rate 

in a normally malure crop when experience indicatos that minimum riponing 

inducoment is roquired. Use the higher rale whon fhe crop is heavy and has 

a londency 10 be more rank or when lemperaWres are lower than normal. 

Always tgst spray to determine if Ihe lobacco Is malulo enough to respond 

10 treatment with PREP'" brand Elhgphon. 

Apply ovor·lho-IOp PREp1M brand Ethephon spray as a fine misl using t~ree 

nozzles (one nozzlo lips over Iho conter of the pial'll, and one o~ ~~~~e~~~1 so aU loavos aro coverod similar to Ihe 

. I .aento. UM a 'm'v , of40 to 60 os! 

Do nol apply PREPn.o brand Ethephon 10 immalure le<l;ves as this can resull in unsalisfactory coloring, welghlloss and reduc:od loaf 

quality. 

Do nol allow the crop to over ripen in Iho fiold aftar using PREpru brand Elhephon. since this may cause some reduction in yieki and 

quality, 

Do net treat belore anfidpatod major slorm which could pre.ven! harvest and resul! in ClOp loss. 

Do nof apply PREPN brand Ethephon if rain is expaclod w~hin 4 hours. 

APPLICATION TIMING 

Successful resulls with PREpnI caJi for Ircalmonl when leaves aro malure, nor overly rank green when sprayed. To oasily detormine 

Ihe proper Iraalmonl timing and Iho number otleaves per stalk ready for harvest, lesl spray several plants in more than 01'10 location in 

each field and obsorve the response. MaW"" loavos will begin to yellow In 2410 72 hours, Toslleaves that fail 10 yollow in 72 hours are 

not mature and are nol roady for PREP'" brand Elhophon Iroalmonl. Wa~ a tew days 10 permil furthor natural maturing, fhen make 

another tosl spray or -malurily" check, 

.-wOOn you have contirmed Ihe number of leaves per plan! Ihal will color, you can dolermmo Ihe number of acres to Ire.al in order 10 fill 

~ebam. . 

Prepare your lesl spray by mixing one loaspoon 01 PREP'l>< in t quart 01 WaltH. Spray each test planl wilh about 1 oz. of this mixlure, 

covering aU leaves with a fine mist. PREp1M brand Ethephon will not color immature sprayed leaves. 

WHEN TO HARVEST 

All maturo, sprayed !eaves w~1 bogin to color w~hin 2410 72 hours arler PAEp1l>< brand Elhophon applicalkm, The yeUowing process IS 

woathor dopondont; cool wealher will delay, while hoI, sunny wealher can speed up Ihe process. Harvest Irealed Ichaceo whon loaves 

havo reached Ihe d&sired color inlensily. 

Do nol allow lobacoo to become over ripa berore slafting harvest loal drop can occur when lobacco is ovor ripe and leI! on Ihe slalk. 

" a number of tho bottom loavos have yellowed allhe time. otlrealmonl. thoy should be harvestod prior to spraying with PREPThl brand 

Ethophon. 

With an over-lho-top applicalion, harvosling can commence 24 hours aHar PREpl" brand Elhaphon applical/on depending on wealhor 

conditions or 10 avoid over dpa tobacco. TobaCCQ harvested 24 hours aller Iwalmonl win require more lime in Iho coloring phase 01 Iho 

curing process. 

CURING PREpnI TREATED TOBACCO 

Curing proceduros are as much an act as a science and oach cure musl be judged on the basis ollobacco condition, inferval between 

treatment and harvest. weafher and type of curing facility berore pro5criplion temperaluro and vonlilalion schedules can be 

established. To oblaln maximum qualilY, cam musl be laken 10 obsolve and control tho curing process closely, especially during Ihe 

late "coloring~ and oarly ~drying~ slago$ of Ihe leal. 

PREpN brand Ethephon treated fobacco will have started the coloring process when halYosled, rGducing the lime roquirod in the 

coloring phasa of curing. Treatod lobacco should be dried fasler. II tobacco leaves aro groen or contain somo green when harveSled, 

it may bo necessary to color Ihom for a few hours. If Ihe 11J3ves are complnlely yellow, temperature and venlilalion musf be adjuslod in 

a manner to dry the tobacco as fasl as possible wilham scalding. Once tho leaf Is dried (3/4 dty), you should follow norma! procodures 

ror curing, Since PREpr>.< brand Elhophon !realed leaves cure laster, treated and untreated loaves should nol be cured logQther in Ihe 

same barn. 

180 
LIMITED WARRANTY AND DISCLAIMER 

The manufacturer warranlS (a) Ihallhis product conforms to tho chemical descriptfon on the label; (b) thallhis product [s roasonabfy lit 

tor the purposes sot forth in the direclions lor use whon ~ Is used in accordance with such directions; and (e) that the directions, 

warning and other sta10ments on this laOOI are based upon responsible exports' ovaluatlon of reasonablo tests of elfeclivoness, of 

toxicity to laboratory animals am:! to plants, and of residues on food crops and upon reports of Hold experience. Tests have not boen 

made on all \lariotios Of in all stales or under all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT 

EXPRESSLY EXClUDES AND DISCLAIMS All IMPLIED WARRANTIES OF MERCHANT-ABILITY OR FITNESS FOR A PARTICUlAR 

PURPOSE 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLElY RESPONSIBLE FOR, ANY AND ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT, NEGLIGENCE. STRICT lIABILITY IN TORT OR OnlERWISE SHALL BE LIMITED. AT THE MANUFACTURER'S OPTION, 

TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE PRICE FOR, THE QUANTITY OF PRQDUCTWITH RESPECT TO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHAll MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR 

CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. 

NOTICE TO BUYER 

Purchase 01 this product does not conler any rights under palients governing this product or tho use thereot in countries outsido 01 the e Unitod States. 

lDEF and Guthion are registered Iradomarks ot Bayor AG, Germany. 

2Dropp Is a registerod trademark 01 NOR-AM Chemical Company. 

3Harvade is a rogistered trademark of Uniroyal Company. 

~Malalhion is a tradomark of Amorican Cyanamid Company . 

• 

Rhbne-Poulenc Ag Company 

P.O. Box 12014, 2 T.W. Aloxander Drive 

Research Triangle Park. North Carolina 27709 

PREP is lhe trademark 01 RhOne-PoullH1C. 

FOLEX is a registered trademark 01 Rh6no-Poulgnc. 

PREP111 brand Ethophon for Cotton and Tobacco (PENDING) Submitted _'_'93. 

181 
PINH IWJd Jnstrvctlon. on 10m>. "" OM", ".~." 

(A) & EPA 

Unltotl ,StaID& EnvlmM!lfrll.Gl PmlGdion Agoocy Registration IOPP IOOntificr Numbor 

Offioo ofPestlcioo Prograrm.; (H7505C) 

Wnshlng1af1, DC 20460 ~ Amendment 

Application for Pesticide: Other 197005 

t. ComfWl'lfProducf Number I', I" 264-418 C. G. 

4, Com~JProduet (Name) PM. o Nonl} o RostnclOO' 

PRE rand Ethephon for cotton and 22 

5, Narno and Address of Applicant (Include ZIP C<xfe) 

I ~~uct ;, s;(,,;;:, 0' ~.ot~a: :~~mpo'Won and "b~';ng Rhone-Poulenc Ag Company 10: 

2 T. W. Alexander Drive 

RTP, NC 27709 EPA Reg. No. 

D ChecX II this is II rww ar:ldrcu Product Name 

III 

rx . Expfa!tl below FiMI printed labels in response to 

~ ReMlbmitsicn in response to Agency roller datod 

AgOi'l¢)' kntordatod 

r-

!-- Noll/icaoon· Explain below, - "Me Too" ApphcalWrl_ 

~ Other" e:.plain below, 

I Ute addfunal page{&) II nec&stlary (Fer saction I and SQcoon IL) 

Amendment to meet Worker Pl'otection Standard requirements. 

!.!!I.. 

,. 

I 

I' '~Mm. ElY'" Yo, rYes 

- I- Plastic 

. No No No 

j~~a;r ~;;:"!: No:. P'" lI'Ytn,' N0P?' ; I * Certification must bo C¢(Ittiloof Package wgt, OOI'IflUfiOf 

I 13, Nat ConWllt!) lru0fm3ticn I' 51"",) 01 i , I i 

Dlabal E3:S:: t,;"", ... , , P""''''' ,6. ""00"," ; 

= o Other L--- I 

N_ 

~ In". 

Warren A. Davis Senior Registration Manager 919-549-2379 

I • 

I oortily that tho statemenls I havo fl'Iado on this torm and all allacnmM1!5 thereto am true, 3CC\J/alQ and complete, 

I ~ thaI MY knowingly lebo Qr mit;:lnttding ~1tl1mnQflt may be punishable by fino or imprisonment or • 

• • ::: ISII~Mr • • both lJI'loor appfitable law, • • •• • •• • • •• • • • • • • ,. :. 

Ij .iJ ctY-"",-• 

3 Hlo . .. • • ••• 

1tJtf)~ Senior Registration Manager • • • ... • • • • I' T, 5. On" ... •• • • • • • .. Warren A. June 2~ 1993 • • • • • Davis • • • ••• 

l ,a_~? """" ,"".12""', "m, wp,,· ... ,,. copy 

-,-~--- '4 
• ••• • 

PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

" ~~~r~§~~~~i~~~~~~~~~~'~"~~thf:'~'~'!;'~tl.ectloo of infoNfllltlcn Is Htl'lMt«f 

'-£earthing ¢xistlng dottD sourees, gathedno and 

Send COImI«It$ r*9*rding the I::!urden 

redUcing thl$ burden, to Chief, 

";;;;. ;..,.;,. street, • \lllth Ington. DC 2~6(); and to the 

,t Uuhfngtoo, DC 20503. 

INSTRUCTIONS: This form 1z to I.:c UG:ed tor' litt afJPticlItlene for row r~istratlon. end use rflregistratlon, ~tJ resui:rl!issfon, to tlpplicltiOM 1Qr Mtfflc:lttiOM, HNit 'printed l!lbeting. reregtlltratioo, (lte. 1n order to prOCHS an 

epp{icctlon for fI ra\f registration subMitted on this tONI!, the tct{'OWing Nted.' l!USt iK:CQI!!PMiY tbe appl1catlom 

1. CertifIcation with R«piMt to Cit.tioo of Oll:ta (EPA fQf'l!l 3$70-29). tIf not IIXetllpttd by «I eFR 152.81 (b) (4)1; 

2. Confidantlal Statement of fonmula (EPA form 8570'4); 

3. fW"lIUlator'$ Ex~ion St.1tOO'Mlt (I:PA (ONil 8510-27)( 

4. five cup!u of dl"Oft tnhl'!t log; 

5. Thr" cop; esc of illYf data s\..tmi tted; 

6. Authoritatlon letter Wh,re appticabte; 

7. H!ttriCH wft"re appl icable-. 

Sul::rnission of l4b@till9 ~ Labeling M:QUld firtH be su!.mltt«i in the form of draft labets >lith all appticatiooa for pew 

re-gistrAtion. Soth draJt lAbels ~y be in t~ form of t';'p«f tllhd te",t on 8.5 x H ioch p<lper or II: Irt;Iektip of th.'proposM 

tabel. If pr~ted lUi II mockup, it shoold be cOf1SthlCtl!d ftl MICh II: W3'f at to foci I ittlte HOI·. fn nn &.5 x 11 ineh 11 til'. 

IW:bJp tabels significantly Ulat!er thllri 8.5 l( 11 illiChli111 Would be ~ted OI'"! 8.5 x 11 fl"l(;h paper 10; 5.1";$100. 

Stba:iooion 01 tMtD ~ DAtil' SubmItted In rHlp(>rwt of this ~tlciltiQO IiJJ$t I» !Hb:IIltted in lKtOnw!C1I' with Nt notice 86~5. 

SPECIfIC lNSIRUCnONS: PtclIs.e read the imtructicro nated below befofd cOOlptf'ting this awtfClltlOO. rlrst tit 

dttermlM the t'fi,W of r&gi!ltr!!tim Ktten, Ihioo In !Hod; A, for lA1ich you l.Irf! stbnittfng thh- ~pplic.tloo. fot 

applications !ltA::ffiltted tn CCN',cCtlOl1 ;.-ith Nm< Registration M;tl&Ul, Sect1Gf"'':: t, HI, tind IV !lUSt be cC&pt¢ted by the 

IIWHcent. For ~ticlitjmm iltt.w1itttd 1(1 e~tiOf! whh ~ rwghtration ectiOl'\$, f%l.ib'!!l:;ulornl. mtiHe.atiom:, 

reregi5tratlons. etc., Scctimm I, fi, and IV must be ~Gmplet$d by the applicant. 

!tock A ~ Chw.J: till! &f'P!'opflllte ~Ct10f! for \<tilth you l\r~ lIu1.:e!!ltdm this ferm. 

SECTION I ~ This 'action !lUSt be uq>i0tod, sf. IIf?tic4ble, ftft all (69)sti"J>ti«"t utiont. 

1. to=pQnyjPn:c.,Ic1: lk.Iaber ~ lrmert ytNI" ~ UWber, If (l()t las i:»tm 3$$1~ by EM. ,hh; ~r may have ban usi{llWd 

to' yw as l!I bMik reglMr$l"lt, a dl&tdbwtOf, or n 1m estftbti~t. If '11:J'Jr p-tl4Jc:t i% r;tgigter£'d, jfiM:rt the PrOWet 

2. EPA -. proc:k.let ~r - tf ~, flit in til'" ~ and FH ~r of the EPA PHXioct H~.r, 

3. p~ C\.-stfiC4tien ~ $~c!fy the pr"i'A>lI00 ehlssifieatlon of this p!"~t. 

4. ProdJet I4lIIIile - Enter the ewpt&tt! priXklct n.Ii!IW! of thb putlthk M, it witl ~r co the label. 1M _ JI'UIlt, 00 

ilpedfic to this pr<'JdK:t ooly. DllpticutlOf! of ~;s not pe-rn;ittMi :w.cns prtXluca of tile ilMie cMpMl'f. DQ nOt indudtt 

IM'f{ brand NIIM or c~ lim desisnetiom:. 

5. ~ and ~ 01 AppliC$lt - The I'W\W of the firm,zr peNon /ltd ilddreit -sh«m lh yO!.lf' applicat!on i$ tbl!: pUS«'! or fi/"n 

to J4wm the t~1stfntiCf1lfi!t be islloro. If YlXl are acting \1'1 WI1alf of G!)Oth;rr ptlrty. yoo mJ$t $\b;Iit autl\ori%!ltlanfrOO! 

tllat party to lIet for lhe'll Iii rt>gi&trlltioo NttcrC. An applicl¥1t \¥It rcsidl/'lg in the United Statim II'ltSt hnve 00 

authorbed agu"lt residing In the untted Statoo to act for tl\(tM ill att reghtrnion utters. ,Mil r'\lIiIOO and IXlQPtetemiling 

addNn (If $\lCh an lIgt'nt Pl-Itt atC~ thts appllcatton. 

6. bpedittdl'{evielll ~ ftfAA $!teflon 3 (e) 3 on providac fOf" e~ited rtwlom of II!jlPlicatfOO3 f{;r f~istratiOfi, or ~ts. 

to existing regfstruiom. fhit !Ire simil;!lr or fdentlul to other fJ"ticlde produt-ts that are (:Uf'rently regh.u~red with 

the EPA. ro order fer yoor IIWlk4tliXl to' be eltgible for e~ited reviw, yoo N4St provide tm: with the EPA ReSlsttBtiOfl 

Utsrber end prcd.let I'llI/l1e of thll! pr«loi::t yoo bel1lWe III ~irilHar to or identical to your predJet. ,he prodoet JlLl$t be 

simlt&r or ldeotiul tn both fornottitiM MId In\wt&d WIll'S. 

SECTION II ~ ,his section II'I.St I» (o:rpfeted for all IIWlt¢atl~ subJlltted to t>IIm1d tllf!- rcghu&tton ooly 'Of l!I cu.-r~tly 

regisured prtduct (Alaanr.nenU, for b ruubmhsiM 11'1 r~e tQ Ul "OUlCY tetter, for I'lOtif1(lItiornl to the Agem:y~ fer'tlle 

~{ssion of (I hal printed tabeling. for rereg!strction and for any other ~~len that pertftin$ to 11 §p?£ifl y tea~rSaj$t*red 

~. 1hi!" ll«tlon h.!:12! 12 J2! t)&ed for 1'1 lWW appt.i(l'Itton fer registrl'lthm. 

1. su,jeet of t>tb!IriNiOl'"l - Chock thO'! "Wi iel'lble bt;')C1; M1d previdw tlw ~ 11'ltt1li" date If 1JPPf~·d&te. Provi~ II brief 

explanation of the purpote{s) for the submission, $Uth ~s atht $ddition of U site, P*5t or crop {$pcclfY)~; ~&mend the 

confidEntIal natlffllUlt of for:rula by ..... ; "rerC9istreticn slbha;h::o"; smwf'lIl f~l fev!,;i¢/'! of \)$* dtfeetl~." AUath 

a ilGplIrate page It IIddltlcml g~e is Mooed_ 

SECTION HI (pacKaging: and CQnUin~i!J.1.Q.t'1'f!itioI1) . 1'h12 $%ction wtt IX" c~l{'tctl fot" oil &F¥>I ieHioot 

Mbnltted in e~.;;tim with new rcgl:l-tratloo Dr #Wtittht~ ~tt. 

1. Type (if fI~it\& - Chwk tb: ~ovdBt€l tAxk if y;xr p.rndv;;t ltiE b0 pM;b1ifrd In ">,;, mdirat(-J rw;<-31li-r>i! t)-"fW:$. 

Indicau til*" sin of d\¢ indhddl.mi fCd¢l¢t$ v-d N;;Woor jX'f tet-lli\ c«>{aif)t!f". 

Z. lype of'Jltf!till!H CMt1l10&l" - lr,jitllte hpe of tlYlt~IMr ~n :#lkh ;;itt'w!Hphtcd, 

3. L(lI(;iItitllh of U¢t fAmt'ltrtt& - ~dfy ,hI' mt £;y;tN1H !:If kit c;;flU1Mr& for '(OOf Ffodoct. 

4. Sinta},4'i ltataH·~¥ ~ Gpedfy rfA rwt su>t&n" of 4lt retll\[ VmnliIYF5 ifF? )X@fl:t 

!. LQt'o.: cl CM U-i_ti'ooo w Irxlitllt& Ifw to\:4t1Oh 0f th& 4$01' ulr&ctif-r-:-1< f¢f "fO'H 

6.·~·tn Jiltdf 1M- U jlffh:w to F;yfrxt ~ 1r41utJ; I!w htnod pnmu(t l.toot ;;; at1;tdlW: to hteH o:mtllirll1r • 

••• •••• • • •• 

SECTION IY. !tkmti~t point} . Hde !«tfO!l 0.ln be <:~!ijti¥J ffir !lit eppticsti&w f(j~ !l:~S'~tratk1'i w;tiOOk, l.e., 

new pn:ducts r~lsTI"ntion, rcsutnissioo, "m&"t()(l," reregl$trlltiOfl, etc. 

1-5. !lM'-«;pta41t:1>ry. 

6. ~~~~~: 

• • ••• ••••• • 

183 

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• 

• 

• 

WORKER PROTECTION STANDARD 

CERTIFICATION STATEMENT 

I certify that the revised labeling being submitted for: 

PREP Plant Regulator 

EPA RnGNQ. 254-418 

P. , 

is in complete accordance with the labeling requirements 01 PR Notice 93-7, which reflects 

the reqUirements 01 EPA's labeling regulations lor worker protection slatements (40 CFR 

part 156, subpart KJ. Where exact language Is specified in the PR Notice, I have used that 

language exactly, in the location specified. J further certily that no revisions are being 

submitted other than those directed by PR Notice 93-7. I understand that it would be a 

violation 01 FlFRA if J or my supplemental registrants were to sell or distribute this product 

after April 21, 1994, without amended labeling complying with the requirements of 40 CFR 

part 156, Subpart K. . 

8120/93 

Warren A. Davis 

Senior Registration Manager 

The acute toxicity categories (I, II, nr, IV) for this product as entered in blocks 3-7 on Part I 

of the Product Worksheet are: 

3 Acute oral toxicity 

2 Acute dermal toxicity 

2 Skin irritation potential 

I Eye irritation potential 

3 Acute inhalation tOXicity • " • • • • •• 

• • • • • • · " • 

• " . • • • • • • • • • • • • • • • 

.. " ,. •• • • ... " . . . " .. . . " . . " ... 

• 

• • • • • " . • • • • • 

184 .. -.~ ... --------------' 
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• 

• 

ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Ethephon (2-Chloroethyl) phosphonic acid· .. _ ......... _ ....... " ... _ ........................ _ .... 55.4% 

INERT INGREDIENTS: ...•.....••••.•••••....••.••.••.•••••..•.•••••••.••••....•..•••.•••.••. .44.6% 

'This product contains 6 pounds elhephon per gallon. 

EPA Reg. No. 264-418 EPA Est. No. 264-PA-01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUCION AI..--USU.AA~t>~ffiq~&1~UGto-.n~~ 

ampliamonto. 

For MEDICAL And TRANSPORTATION EmergenCies ONLY Call 24 Hours A Day 1-800-334-7577 

For PRODUCT!J..S.E. Information Call 1-800-334-9745 

Tho use 01 this product for a variety of plant growth (ogulation USGS aro protGcted by United States and foreign patents including 

U.S. Patonts 38,791.189 and 4,240,819. No license is granted 10 use this product in collnlries other than tho United States or lor any 

use not confompfat&d by this label. Liability lor patont infringement may result Irom use or sale of this prodUct outSide tho United 

States. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold oyelids opon and !lush with a gontle stream 01 waler for at loastt5 minutes. Get medical attention. preferably an 

ophthalmologist 

IF ON SKIN: Immodiataly wash skin with plenty of soap and water. Remove contaminated clothing and shoes. Wash Clothing 

soparately beloro reuse. 

IF SWALLOWED; Do not induce vomiting. Promptly drink a largo quant11y 01 milk, egg whiles, gelatin solution or if these are nol 

available, drink large quantities of water. Avoid alcohol. Call a physiCian immediataly. 

IF INHALED: Romoye Yidim to Irosh air, " not braathing, giye artllicial respiration. Administer oxygen if nocGSS<1ry, Got mOdical 

atlenfion. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS e CORROSIVE Causa:; eye and skin damage. May be fall'll if absorbed through skin. Harmful II swallowed or inhaled. Avoid breathing 

spray mist. Do not gel in eyes, on skin or on clolhing. -Wear...fuJWGfl9th-UQI,j~~~Io'lec, and goggte; or 

faoo chiold w~~~~iy.,-Wad:!.tlwr~aAdwaIGr af1~.bofot.Q-UIffig, 

~&mI)\,Ig and wa;~t3m~~~ Keep away fr(lm domestic animals. 

NOTE TO PHYSICtAN 

Thero is no spedfic antidofe, All treatment should be based on observed signs and symptoms of distress in the patient. Overexposure 

to materials other fhan this product may have occurred. 

Victims of seyere ovoroxp(lsure, by inhelation, should be kept undor modical obseNation for up to 72 hours lor dolayed onset of 

pulmonary edema. In a victim of ovor-expoSure by ingoslion, carolul gastric 13vago is rOQuifltd due to the possibility 01 stomach or 

esophagoal porforation. This material [s an acid, but usn of alkaline $ubstancos to neutrafi2:a it is contraindicatBd. 

ENVIRONMENTAL HAZARDS 

For terrestrial uses, do not apply dlrGCtIy to water, or to areas whom 5uriaco water is presont or 10 intertidal areas below the mean high 

water mark. Do not contaminate water when disposing of equipment washwalers. 

Do not contaminate watnr used for irng3tion or domestic purposos. 

USE PRECAUTIONS 

Do not apply PREpn. brand Ethephon through any typo of irrigation systom. 

Avoid spray drift 10 nearby crops as this product wi!! cause modifICations in plant growth. P!antlnjury or reduced yields will result. 

Do nof plant anofher crop within 30 days Oilier troatmon!. 

Mix only the amount of spray yOll axpoClto use 94ch day. Do not allow mixed solu1ion to stand overnight. 

185 
• 

DIRECTIONS FOR USE 

If fa a vlotation of Fedoral Law to use this product In a manner Inconsistent with Its labeling. 

Read enttre fabor boforo using this product. 

R-i~RV STATEMION+ 

Mixors, Ioad4ta <lAd 3jilplic&tono mUGl 'Noar a lu~i&Id,-~roIOGorlS, Igng-&~~,-9IoIJ-.a~ro-avol~ 

and eye GOnia", 3& per;sibl&. 

00 not oRleH troated Ij.«I& wiUli4-2~ alter appiicamm-unle&c p~~~m. 

not eonIsm inato water, tcod, or feed by storago or disposal, 

oontainor is broken or contents havo spifled, follow an precautions indicated' above and clean up immodiarofy. Bolero cleaning up. 

full length trousers, long sleoved shirt, protective gloves, and goggles or face shiold. Soak up spill with absorbent media such 

sand. oanh or other suitable material and dispose of waste at an approved wilste disposal tacility. 

DISPOSAL 

j wastO$ arG acutely hazardous. Improper disposal of oxcoss pGsticide, spray mixture, or rinsate is a lIiolalion of Fedoral law. 

theso wastes cannot be disposed 01 by use according to label instruclions, contact your Stato Pesticide or Environmental Control '"g.,,,,>, or tho Hazardous Wast& representatille at the noarost EPA Regional Office lor guidance. 

GENERAL INFORMATION 

COTTON 

A folrar spray 01 PREpnt brand Efhephon Will accolerate opening of mature unopened cotton bolls and enhance detofiation which can 

result in oarrlOr harvest wHh an incmas&d recoverablo yiekl. PREplM brand Ethephon treatment on cOlton allows increased eltidoncy 

from a once-over harvest. 

TOBACCO (FLUE-CURED): A foliar spray at PREP 1M brand Eth&phOn promolos early. uniform "yellowing" of mature tobacco. 

PREP"" roduces curing time, allowing mora efficienl use 01 curing barn space, and increased control over harvest st::hedules. 

SPRAY PREPARATION 

Add 1.12 10 3/4 01 tho roquiro-d amount 01 water to tho spray lank. Stan agilallon. Add Ihs required amount of PAEpTI.! brand EthOphon, 

and the remaining amount of water. Prepare only as much spray solulion as can be usod on tho day 01 mixing. Do not allow spray 

solution to stand overnight. 00 not spill the concontrated producl on spray equipment, or any airplane parts, 

ANY SPillS SHOULD BE RINSED IMMEOIATELYW!TH PLENTY OF WATER. 

• 

Use at a nurse tan~ is highly rocommended for alloiding poSSible spiffs of concentraled lormuiation on spray equipment or any airpfano 

parts. 

TANK MIXTURES WITH DEFOLIANTS AND INSECTICIDES 

PREPn; brand Ethophon is compatible wilh OEF I , FOLEX®, Oropp2, HalVade3, Methyl Parathion, Guthiont, and Malathion4 • PAEPfl.! 

may be appliod in soquence or as a tank mixture (DO NOT TANK MIX WITH DESICCANTS IF COTTON IS TO BE SPINDLE 

HARVESTED). Follow all applicable usa precautIOns and rale per acro rocommendahons on labels 01 products appHed as tank mixlures 

or in sequence with PREP nI brand Ethephon. In some caSlls Slight reduction in boff opening rosponse has beon observed whon tank 

mixes with dofo/lants wore usod. 

Good agitation in tho spray tank is Qssontial and a tank mixture· should not be alfowed to stand Without agitaHon lor more Ihan 5 to to 

minutes. Read and observe all appropriate labol usa diroctions and procautions lor the detoliants and insecticides usod. 

NOTE: Undor conain conditions, lank mixtures 01 PREpn. brand Elhephon with desiocants conlaining sodium chlorale could 

resuff in the lormation ot hypochlorous acids which on heating win emit loxic chloride tumes. 

EaUIPMENT cLEANING 

Bocausa 01 tho acidic nature of thIS product, prOlonged e:.:pos-ura 10 spray deposit will damage acrylic plastics, certain painls, and 

mefals. 

Rinse thoroughly with a detergent and water all exposed acrylic plastic·type materials (e.g., aircraft windshields), and painlad surfaces 

wHhln an hour aftar expcsuro to spray deposits. 

At the end of each dey, rinse Ihoroughly with a dotergenl and water aff the melal parts of the aircratl and the associated spray 

equipment exposed to th9 spray doposits. 

186 
• 

COTTON 

EXPECTED PREpT" ONE SPRAY VOLUME APPLICATION 

USE CONDITIONS RATE GALLON (Gals/A) TIMING 

PREP!).! 

TREATS 

Plnta/A LBS A.1. Acros Ground Air-· 

PREpm Hot and d"l aO"F or 1 113 1.0 6 Apply whon the number of 

Boll Opanor· higher mature unopened bolls is 

Dry and 75 to ao"F 2 1.5 4 2·5 

sufficient to produco !he 

15 ·50 dosirod crop. SOQ below for 

Coo! but abovo ssaF 22/3 2.0 3 lest 01 boll maturity. 

Treatment uniformly opens 0' bolls 7 to 14 days earlier. 

Rank cotton 

PREpfl.! + High soil moisture ,/3 0.25 24 15·50 5· 10 Apply 4 to 7 days prior to 

FOLEX» 0' PREP"'" boll oponing 

Oofollant Tank High fenility love-I application. To bo usod as 

MIx a sequonlial treatmont wi1h, 0, not in place- of PREPTM bol! 

Rank cotton opening treatment. 

PAEpN+ Cropp2 High soil moiSTure 1/3 0.25 24 10-50 3 -to Apply -4 to 7 days prior to 

Oofollant Tank High fOrlilily lovol PAEpTM boll opening 

MIx Rank cotton 

application. To bo used as 

a sequ&ntial1re8tment with, 

not in place 01 PREPTM boll 

opening1raatment. 

Pro·Condltlonar Hot. dry, above 80~F 2/3 0.5 12 Apply 4 to 7 days prior to 

10' Oofollatlon Cool, above 65~F 11/3 1.0 6 15·50 2 ·5 dofolianl. Enhances top 

crop dalollation reducing m deterioration of bottom crop 

Rank cotton and allows lor earlier 

harvest. 

·Pl't:treatment With Defoliants Prior to PREPTM Boll Opening Treatment 

If the cotton is ovorly rank or laying down in the middle. and good spray coverage ot the bolls whh PREpm is dlfficun, a pretreatment 

with deloliants will be usatulto improve boll coverago with PREP,..., Use dosage ratos ot PREpm brand Ethophon recommended for boll 

opening. Read and observe all appropriate label use diroctions and precautions tor tha dalolianl usad. 

"In California and Arizona USQ a volume of no less Ihan 5 galklns par'acre lor aerial applications. e BoU Maturity 

A boll is matule whon it is too hard to be dented when squeezed bOIWQen thumb and fingers, 100 hard to bo slicod with a sharp knile, and 

whon tho seed coat bocomes light brown in color. 

Use Limitations 

Do not exceed a maximum 01 2.0 lb. afJA tor combined uses ot PREpTM per acrO per year. 

Boll Opening: Do nOl1ank mix PREpN brand Elhephon with a desiccant it tho corlon is to be spindlo harvested, 

Pro·CondiTlon lor DeloliaTion: Do not tank mix PREpru wilh desiccants unloss plant desiccallon is requirod. Do nOlose a defoliant 

belore there is suflicient maluro unopened bolls to producelha desired yield {see Gunoral InformatiOn section on how 10 test tor boll 

maturiTy. 

WHEN TO HARVEST COTTON 

Do not harvest collon sooner than 7 days alter a treatment with PREpn.. brand Elhophon, 

Observa the treated crop and harvest when optimum bon opoolng has boen reached. Too early haNest might reduce tho lull advantage 

of the trealment and too lato a harvest may result in reduced quality and loSs 01 lint which wi!! drop Irom Ihe plant. 

187 

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• 

PREprn 

Crop Sltuat/on Plnts/Acre 

Directed Spray 1 1/3 

Application 

OVer·The·Top 1113-22/3 

Application 

USE lIMITATtONS 

TOBACCO 

(Flue-Cured Only) 

Spray 

Volume 

Gallonsl Spociflc Directions 

Acro 

50·60 Uso drop nozzles. Chooso TG or OC spray lipS designed to apply SO • 60 

gpa at 35··10 P" aod at tractor speed of 2·3 mph. U" 

2 nozzles por row; one on each skle 01 the row droppod low anough to direct 

tho spray to tho loavos to be ripaned and harvostod. Thorough spray 

coverage is essential. With a directed spray, be sure to harvest all loaves 

with 20% or mor. yo/lowinq. 

40-60 Treat only when leaves remaining on the stalk are maturo. To onsure 

remaining loaves are maluro, test spray sovoral tobacco plants as 

described under the section ·Proper Timo 01 Treatmont: Use the lower rate 

in a normally mature crop whon experience indicates that minimum ripening 

inducement is roquirod. Uso the higher rate when the crop is heavy and has 

a tendency to be more rank or when temperatures are lower than normal. 

Always test spray to dotermine if the tobacco is mature enough to rospond 

to treatment with PAEpn.I brand EI hephon . 

Apply over-the-lop PAEplM brand Ethophon spray as a line mist using three 

nozzlos (one nozzlo tips over the center ot the plant, and one on each skle) 

so all leaves aro covered thoroughly, similar to the application pattern ot 

systemic sucker conlrol agonts. Use a spray pressure ot 40 to GO'psi. 

Do not apply PAEpN brand Ethephon to immature loaves as thiS can result in unsatistaclory coloring, weight loss and roduced loa! 

quality. 

Do not allow Iho crop to ovor ripon In the hold aftor using PAEf'ThI brand Ethephon, since this may causo some reduction in yield and 

quality. 

Do not treat botora anticipated major Slorm which could provent harvast and rnull in crop loss. 

Do not apply PAEf>1l< brand Ethephon if rain is expected withm 4 hours. 

APPLICATION TtMtNG 

SlliX:eMlul results with PREpTM call tor troatmont when leaves aro maturo, not overly rank groon when sprayed. To easily dotermine 

the prop.ir Iroatmant timing and the number ot loaves per slalk ready for harvest, lOst spray sevaral plants in moro than on& location in 

each Hald and obsefVo the response. Mature loaves will begin to yallow in 24 to 72 hours. Test loaves that tail to yellow in 72 hours are 

not mature and are not roady for PREpno brand Elhephon treatment. Wait a taw days to permit further nalural maturing, thon make 

anolher tast spray or "maturity" chacko 

• 

Whon you havo confirmed Ihe number of leaves per plant that will color. you can dolermin(il the number 01 acres to treat in order to Iill 

the barn. 

Prepare your tost $pray by mixing OnG teaspoon ot PREP'" in t quart 01 water. Spray each test plant With about t oz. ot this mlxlure, 

covering aU leaves with a lino mist. PAEP~ brand Ethephon will not color immature sprayed leaves. 

WHEN TO HARVEST 

All maturo, sprayed leavos will txlgin to color within 24 to 72 haUlS alter PREP'" brand Ethephon application. The yellowing process is 

weather dopendont; cool weathfu wiO delay. while hot. sunny weather can speod up the process. HaNost troated tobacco when loaves 

have reachod thO' desired color intensity. 

Do not allow tobacco to become over ripe boloro slarting harvost. leat drop can occur when tobaceo is over flpO and lell on the stalk. 

II a numberot tha bottom loaves hava yallowed at tho time ot treatmenl. thoy should be harvestod prior to spraying with PREP'" brand 

Ethephon. 

With an over-the-top application, harvesting can commence 24 hOurs atter PAEprn brand Ethephon application dOp.inding on weather 

conditions or to avoid over ripe tobacco. Tobacco harvested 24 hours alier trealment will require more time in the coloring phase 01 the 

curing ptocess. 

CURING PREp-rn TREATED TOBACCO 

Curing procedures are as much an art as a science and each cure must be judged on the basis otlobaceo condition, interval between 

troalment and harvos!. woather and type 01 curing tacility beton) prescription temperature and ventilation schedules can be 

established. To obtain maximum quality, care must bo taken to obsolVe and control the cUring process closely, especially during the 

late "coloring" and early ~drylng· slagos 01 the lea!. 

PREpN brand Ethephon treated tobacco will have started tho !Xlloring process whon harvested. reducing the limo required in the 

coloring phase 01 curing. Troated tobacco should be driod taster. If tobacco leaves are green or oontaln some green when harvested, 

it may be nocessary to colorthom tor a few hOurs. II the leaves are completely yellow, temparature and ventilation must be adjusted in 

a manner to dry the tobacco as tast as possiblo without scalding. Onca the leal is dried {3/4 dry}, you should tollow normal procodures 

lor curing. Sinco PAEPr.I brand Ethephon tteated leaves cure laster. treated and untreated leave$. should not bo cured together In the 

samo bam. 

188 
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LIMITED WARRANTY AND DISCLAIMER 

Tho manutacturor warrants (a) that this product conlorms to tho chomical description on Iho labol: (b) that this product is roasonably tit 

lor tha purposes set lorth in tho directions for use whon it is used in accordance with such directions; and (c) that tho directions. 

warning and olhar statomonts on this labol aro basad upon responsiblo exports' evaluation 01 reasonable tosts 01 olfoctivonoss, 01 

toxicity to laboratory animals and to plants, and 01 residues on food crops and upon reports 01 flold experience. Tosts have not been 

made on all varieties or in all slates or undor all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT 

EXPRESSL V EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANT·ABILITY OR FITNESS FOR A PARTICUlAR 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES, OR INJURIES RESUL nNG FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT. NEGLIGENCE, STRICT LIABILITY IN TORT OR OTHERWISE SHALL BE LIMITED. AT THE MANUFACTURER'S OPTION, 

TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE PRICE FOR. THE QUANTITY OF PRODUCT Wmt RESPECT TO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR 

CONSEOUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. 

NOTICE TO BUYER 

Purchaso 01 this produCl dOllS not canlor any rights under palients goyorning this prodUcl or tho use therool in countries outsido 01 tho 

Uniled Stales. 

-. !OEF and Guthion aro roglstOioo trademarks 01 Bayer AG. Germany. 

2Dropp is a rogtslerod tfademark 01 NOR·AM Chemical Company. 

3HarvMe is a registofed trademark 01 Uniroyal Company. 

• 

4Malathion is a. trademark of American Cyanamid Company, 

Roone-Poutone Ag Company 

P.O. Box t20t4. 2 TW. Alexander Drive 

RO$oarch Triangle Park, North Carolina 27709 

PREP is Iho trademark of Rhone-Pou/onc, 

FOLEX is a regislered Illldemark 01 Rhone-Poulenc. 

PREprv brand Ethophon lor Cotton and Tobacco (MASTER) Notilication 6/9193. 

189 
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• 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

Warren A. Davis 

Senior Registration Manager 

Rhone-Poulenc Ag Company 

P.O. Box 12014 

2 'r.N. Alexander Drive 

Research Triangle Park, NC 27709 

Dear Mr. Davis: 

SUBJECT: Review of Alternate Formulation 

PREP® Plant Regulator for Cotton 

EPA Reg. No. 264-418 

Your Letter Dated 11/19/93 

OfrlCE Of 

PflEVENTION. P£SltcIUfS M{l) 

TOXIC SUBSTANCES 

'rhere is no objection to the use of the alternate formula-tion 

(CSF) dated 11/19/93 that was requested in your letter of the same 

date. The amendment has been inserted in the file for the subject 

product. If you have any questions, please contact Terri stowe of 

my staff at (703) 305 - 6117 . 

Sincerely yours, 

Cynthia Giles-Parker 

Product Manager (22) 

Fungicide-Herbicide Branch 

Registration Division (7505C) 
• 

• 

REG. NO:~!~'I/ y ALE SYMBOL: ____ __ 

PRODUcr CHEMISTRY REVIEW FOR END USE PRODUcrS 

TO: PM c2;;>-

FROM: r IH.s-l-o,! 

THRU: -/:b..iJi:lli.. 

PRODUcr NAMES: Bft? fYhlf !?sec/Mer 

hW G.J-fr:;" . 

CHEMICAL:...:-_______ _ 

~ NOS. __________________ _ 

NonF~ Uu. __ ~~~_· ______ __ 

lnerts cleared: c () d () e () yes () no ( ) 

lnerts List I () Other ( ) 

Please provide the requesu:d infonnation for the following checked items: 

I. (1 Submit the prodoct specific prodoct chemistry data for your prodoCl. ( I If 

submined earlier, provide ~ Numbet(s). {} Your prodoct is not sufficiently 

similar to the prodoct your referenced. 

2. In re{e",nce to the Confidential Statement of Fomnda (CSP), please provide the 

following: 

(1 a) pH of prodoct at • specified water dilution. 

[J b) Density of product. 

[ ) 0) FWb point of prodoct. 

[J d) FWb point of product with propellent .. per item #6(q) or item #S(c). 

[1 e) Flash extension of product including flashbacks if noted. 

L,;'J 

fiLeJLt' 

191 
--------------_ .... _ ... 

3. 

-2-

[] f) The upper and lower certified limits based on the pure active ing=:ients 

rather !han the technical or concentrate, 

[] g) The upper and lower certified limits of the individually added inerts. 

[J h) 

[J i) 

[] j) 

Based on the =nt CSF dated,,-_= __ -:---:-' your product will not meet the 

label claim for the active ingredient. Please "'vise the label or the CSF so dill the 

infonnation agrees. 

4. Provide the cbemicaI identify of all components, the percenta&e composili<hl, CAS 

Registry Number, and Material Safety Data S_ (two copia) for the following 

compounds: 

l. 

2. 

3. 

4. 

5. 

The supplier may cootact EPA _y refe!101lcing the File Symbol of EPA 

Registration Number in their response. For <!yeo, provide the color index and CAS 

Registry Numbers for all componenu. For perfumeo and llavorinp, provided for each 

compoDOIII in the mixtute: the <bemical natt1e. CAS Regisuy Number, and the 

percemap or """" in percenta8e in the mixture. Certify that flavors .... non-food 

type. The ('nnfidentj,J infonnation submitted by the supplierl it kept confidential 

under FIPRA Section 10. 

5. In the proposed labeling, provide the following infonnation: 

[] a) Update the label Storage and Pesticide and Container Dupo .. 1 Statements 

in acconlmce with [ ] PR Notice 84-1 for non-ICJOIOI OODIainers for houses 

and institutional ""'. of [ ] PR Notice 83-3 for all other uses. 

192 

• 

• 
• 

·3-

[1 b) Add the hea<fing PHYSICAL OR CHEMICAL HAZARDS to the label and 

the appropriate statement per 40 CFR IS6.1O(hX2Xili). 

[1 c) Under the heading PHYSICAL OR CHEMICAL HAZARDS. list the product 

as extremely Flammable (because your product contains flammable 

propellents). 

[] d) Provide that the solvent does not have insecticidal acnVlty, it should be 

removed from the ingredient statement active ingredient listing and the 

percentage added to the inen ingredients. If the solvent has insecticidal 

.propertie.s. provide the EPA Registration Number. 

[1 e) Add a foomote to the inert ingredients indicating: Contains 

[ 1 f) Since your dara matrix does not provide a dielecttical b£eUdown voltage. you 

must add the following statement <0 the physical or Chemical Hazards 

heading; 

Do not use this product in or on electrical equipment due to the 

poasibilily of shock bawd. 

[1 g) The tertns active ingredicnt(s) and inert ingredients should be in the same 

type size, be aligned to the same margin and be equally prominent. 

[1 h) 

[1 i) 

• . 6. In tefcnonce to the product specific dara require_. provide the following 

infoanation: 

[1 0) S_ of Composition: A complete descriptioa of the manofacturing 

fommlatina proc:eu. Describe equipment used. mixing time. temperature. 

ptellwe. ere. 

[1 b) Oiacnssion of Formation of Unintentional Ingredients: A brief description of 

impurities formed during the manofacturing/fonnulation proc:eu. in packaging 

or during storoge. If you do not expect any impurities during these stages. 

please so stale. 

[1 c) Certification of Limits: Upper and lower limits or each active and 

individually added inen component. 

193 

*Inert ingredient information may be entitled to confidential treatment*
---------_ ..... _ ... 

[J d) Ana1ytico1 Method: Provide the methods used to analyze for the active 

ingredien.. or a full reference for a published method or MRJD Number(s) 

(J e) Color: In conunon terms, 

[J f) Physical State: e.g .. solid. liquid, pressurized liquid. etc. 

[] g) Odor: In common terms 

[J h) Density: e.g .. Ibslgallon for liquid! or IbS/cu.ft for solid3. 

[J i) Ph: Provide pH of product or pH of a specified water dilution. 

[J j) Oxidizing or Reducing Action: Note these _.rimes. if any. 

[J k) Explodability: Note these characteristics, if any. 

[1 I) Viscosity: Can be expressed in centipoise or cenristob. 

[1 m) Miscibility: Note these characteristics if product is an emulsifiable liquid and 

mixed with oil. 

[1 n) Corrosion Olara<:teristics: This inf01IIl8lion can be llOIed during !be storage 

stability study. 

[1 0) Dielectric Breakdown Voltage: For products used .... eIecIrical equlpmem. 

[1 p) Storage Stability: The formulated product inust be malyzed for i1s ac:rlve 

ingIedients 81 time zero and during one yar of storage. The storage ahouId 

• 

be at warehouse conditions of riollpelatute and humidity and Slond in !be • 

product's COIIIlt>m:iJol ptickage. NOie: For !be storage stability study, you 

may not reference !be data on source product coocolllrldle you sre using to 

formul_ your product. 

[J q) ~: FIIIJh poinl/flame extension. The flllJh pow "'P""<d exceeds 

!be one expected for this product. PI...., cbeck and resubmit. Mixtures 

IIIIIRted under pressure, including tho .. containing hydrocalboo.s, are subject 

ill tbeir esrtirety to ..... indicated in 40 CPR Section 1S6.IO(h)(2)(ili) of the 

11IUipactage. Note that flash poin .. for pressurized liquid from !be container 

[1 if any of !be items are not applicable. write N .A. and explain reasons are specified 

uoder chemistI)' data requirements [OOttlo,"'. See 40 CPR Pan 158. 

194 
• 

• 

-5-

7, [J The following is the regulatory status of the inert ingredients under 40 CFR 

180.1001 for for the exemption of the requirement of a tolerance. 

8, Other 

Note to PM: Inter-office use only 

SUMMARY ATIACHED 

195 

.. ----~-.. -----------
..at 

11-1 

41-1 

U-l 

U-l 

U-t 

U-l 

U-l 

• u-, 

U-4 

U·S 

U-I 

U-7 

U~. 

U-' 

U-10 

U-11 

n .. u: 

U-U 

u-u 

• fl-U 

f.,_U 

U-11 

U-U 

fl-1' 

U-20 

U-U 

-

'l'JUIU 1: 

_ 

."... II ... n~ ... u-ut:y .-d. ~.u:.t_ (400'k1S'.ln. lCO, lU, lU. 1n) 

,~c~ !a.t\tUy , pu .. J. ... U. ot Iaqr..t.L.au 

:: •• ".,1ptlotl .. t St&n::I...II4' u.tNul. , KuI.f •• tlUta .. ,~ ••• 

1a.oU •• 1 .... ct r .. _tJ. .. a 1ft :"I"U,U .•• 

_L.. f1-....u, d.I ..... CurtU!._u.- ot ~ ~ (40Cftl.$1:.1'70, 11 •• 110) 

rul~azy ........ ,..:UO ot 'Pdl/;Clt hllpl_ 

CU1:J..U44UOll of ~...u .. t w..ut. 

AIoaJ.yti-.J. ~Iloda t. VuifY e-.rtJ.u-..t t.a.1U 

- ... a..L-.J. <lIII .... ~_ (~,UO) 

~,.. 

'1t~J.-.I. ltat. 

""'-

tt.J.tU4' ... .lAt 

IoUill<r '_Lat; 

o-..J,.~. klJr. c....!.cy. '"' .. ...ttb ¢II:.-r1t' 

.. 1 ... .LUt1 

._ r.-.~. 

O~t1.oa eo...-t 

0du0l/1f&t;_ '!IoIftJ.i:J.ooIt, Co&ffio,i,Mt 

.. 

ftUJ.LUty 

......... - ... - r~UJ,t;7 

w. .. 

... .... = 

'Iu_i..? 

........... 

~Q,q",,,,~ 

l)~ ...... d_ Volu.. 

" -~l. • • 1fU--' 

____________________ __ 

lIlA. - Hot Il'PU-.bt. 

OC - Ou .. eq. 

s:.etio .. --..., ____________________ _ 

0..".: 

196 
DP BARCODE: 0196865 

CASE: 003396 DATA PACKAGE RECORD DATE: 11/19/93 

SUBMISSION: 8453597 BEAN SHEET page 1 of 1 

* * * CASE/SUBMISSION INFORMATION ok * * 

CASE TYPE: REGISTRATION ACTION: 346 RESUBMISSI0N 

CHEl1ICALS: 099801 Ethephon 55.4000% 

10#: 000264-00418 PREP PLANT REGULATOR 

C011PANY: 000264 RHONE-PCULENC AG COMPANY 

PRODUCT MANAGER: 22 CYNTHIA GILES-PARKER 

PM TEAM REVIEWER: TERRI STOWE 

FOR COTTON 

703-305-5540 

703-305-7381 

02/17/94 

ROOM: CM2 

ROOM: CM2 

RECEIVED DATE: 11/19/93 DUE OUT DATE: 

* * * DATA PACKAGE INFORMATION * * * 

DP BARCODE: 196865 EXPEDITE: Y DATE SENT: 11/19/93 DA'rE RET.: / 

CHEMICAL: 099801 Ethephon 

~ TYPE: 001 SUbmission Related Data Package 

CSF: Y LABEL: N 

,:c;,;;;,:cTO DATE IN DATE OUT 

/ / / / 

ADMIN DUE 

NEGOT 

PROJ 

DATE: 

DATE: 

01/03/94 

01/03/94 

/ / / / DATE: / / 

/ / / / 

REVR: // // 

CONTR: / / / / 

DP BC 

* * * DATA REVIEW INSTRUCTIONS * * * 

Per attached 04/20/93 review, the alternate CSF dated 

02/01/93 could not be accepted until the EPA Reg. No. for 

the source was corrected/accepted on the BASIC esp. The 

BASIC CSF vIas accepted per the attached 10/29/93 review. 

Please review the alternate CSF to see if it is now 

acceptable. The registrant has requested an expedited 

review. I am sorry if this has inconvenience you, but 

another PM 22 Team reviewer handled the follow-up (BASIC 

CSF) and I was unable to fol,low-up on tl)e alternate reviews. 

If you have any questions, please call me at 305 - 6117. 

THANK YOU! ! ! 

* * * DATA PACKAGE EVALUATION * * * 

No evaluation is written for this data package. 

* * * ADDITIONAL DATA PACKAGES .FOR THIS SUBMISSION * * I< 

BRANCH/SECTION DATE OUT DUE BACK INS CSF 

197 

229 

261 

/ 

LABEL 
Pages 198-215-*Confidential Statement of Formula may be entitled to confidential treatment*