1

Pyrethrins and PBO Combination Label Table 

This label table incorporates all of the required label changes from the pyrethrins and PBO REDs. 

Description Pyrethrins and PBO Required Labeling Language Placement on Label

All Products

Ingredient statements for 

piperonyl butoxide

--Delete any reference to “technical” in the ingredient statement. (i.e. Some labels refer to PBO 

technical as the active ingredient.)

-- Do not include a ratio of PBO components or percent of other related compounds in the footnote. 

Following is an example of an acceptable expression of the PBO ingredient statement:

Piperonyl butoxide* ......................................................100%

*(butyl carbityl)(6-propylpiperonyl) ether and related compounds

Ingredient Statement 

End-Use Products Intended for Occupational Use (WPS and non-WPS) 

And Wide Area Mosquito Adulticide Applications

[Note: For products with both occupational and consumer homeowner uses, the more restrictive language from these labeling tables must be used.]

Handler PPE Requirements 

for Wettable Powders

Formulations1packaged in 

water soluble packaging

[Note: Wettable Powders 

must be packaged in water 

soluble bags to be eligible 

for reregistration.]

Note: If the use of 

handheld foggers in 

enclosed areas is not 

“Personal Protective Equipment (PPE)”

“Mixers, loaders, applicators, and other handlers must wear:

- long-sleeve shirt, 

- long pants, and

- shoes and socks.”

“In addition to the above PPE, applicators using a high pressure handwand in an enclosed area must 

wear at least a NIOSH-approved respirator with:

-- a dust/mist filter with MSHA/NIOSH approval number prefix TC-21C or

-- any N, R, P, or HE filter.”

“In addition to the above PPE, applicators using hand held foggers in an enclosed area must wear a 

Precautionary 

Statements: Hazards to 

Humans and Domestic 

Animals 
2

Description Pyrethrins and PBO Required Labeling Language Placement on Label

permitted or not feasible for 

the end-use product, the 

statement requiring 

respirators for those uses 

may be omitted.

half-face, full-face, or hood-style NIOSH-approved respirator with:

-- a dust/mist filtering cartridge (MSHA/NIOSH approval number prefix TC-21C), or

-- a canister approved for pesticides (MSHA/NIOSH approval number prefix TC-14G), or 

-- a cartridge or canister with any N,R,P or HE filter.”

“See engineering controls for additional requirements.”

Instruction to Registrant: 

Drop the “N” type prefilter from the respirator statement, if the pesticide product contains, or is 

used with, oil.

Handler PPE Requirements 

for Liquid Formulations1

[including: liquid 

concentrates, total release 

foggers, microencapsulated 

concentrates, foams, 

aerosols, gels, pastes, and 

pressurized liquids]

Note: If the use of

handheld foggers in 

enclosed areas is not 

permitted or not feasible for 

the end-use product, the 

statement requiring 

respirators for those uses 

may be omitted.

“Personal Protective Equipment (PPE)”

“Mixers, loaders, applicators, and other handlers must wear the following:

- long-sleeve shirt, 

- long pants, 

- shoes and socks.”

“In addition to the above PPE, applicators using a high pressure handwand in an enclosed area must 

wear at least a NIOSH-approved respirator with:

-- a dust/mist filter with MSHA/NIOSH approval number prefix TC-21C or

-- any N, R, P, or HE filter.”

“In addition to the above PPE, applicators using hand held foggers in an enclosed area must wear a 

half-face, full-face, or hood-style NIOSH-approved respirator with:

-- a dust/mist filtering cartridge (MSHA/NIOSH approval number prefix TC-21C), or

-- a canister approved for pesticides (MSHA/NIOSH approval number prefix TC-14G), or 

-- a cartridge or canister with any N,R,P or HE filter.”

“See engineering controls for additional requirements.” 

Precautionary 

Statements: Hazards to 

Humans and Domestic 

Animals
3

Description Pyrethrins and PBO Required Labeling Language Placement on Label

Instruction to Registrant: 

Drop the “N” type filter from the respirator statement, if the pesticide product contains, or is used 

with, oil.

Handler PPE Requirements 

for Dusts 

“Personal Protective Equipment (PPE)”

“Loaders, applicators, and other handlers must wear the following:

- long-sleeve shirt, 

- long pants, 

- shoes and socks.”

Precautionary 

Statements: Hazards to 

Humans and Domestic 

Animals

User Safety Requirements “Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for 

washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry.”

“Discard clothing and other absorbent material that have been drenched or heavily contaminated 

with the product’s concentrate. Do not reuse them.” 

Precautionary 

Statements: Hazards to 

Humans and Domestic 

Animals immediately 

following the PPE 

requirements

Engineering Controls: 

Wettable Powders packaged 

in Water-Soluble Bags

[Note: Wettable Powders 

must be packaged in water 

soluble packages to be 

eligible for reregistration.]

“Engineering Controls:”

“Water-soluble packets when used correctly qualify as a closed mixing/loading system under the 

Worker Protection Standard for Agricultural Pesticides [40 CFR 170.240(d)(4)]. Mixers and 

loaders using water-soluble packets must :

-- wear the personal protective equipment required in the PPE section of this labeling for mixers and 

loaders, and

-- be provided and must have immediately available for use in an emergency, such as a broken 

package, spill, or equipment breakdown a half-face, full-face, or hood-style NIOSH-approved 

respirator with:

-- a dust/mist filtering cartridge (MSHA/NIOSH approval number prefix TC-21C), or

-- a canister approved for pesticides (MSHA/NIOSH approval number prefix TC-14G), or 

-- a cartridge or canister with any N,R,P or HE filter.”

“Pilots must use an enclosed cockpit that meets the requirements listed in the Worker Protection 

Precautionary 

Statements: Hazards to 

Humans and Domestic 

Animals (Immediately 

following PPE and 

User Safety 

Requirements.)
4

Description Pyrethrins and PBO Required Labeling Language Placement on Label

Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(6)].” 

“Human flagging is prohibited. Flagging to support aerial application is limited to use of the Global 

Positioning System (GPS) or mechanical flaggers.”

Instructions to Registrant: 

Drop the “N” type prefilter from the respirator statement, if the pesticide product contains, or is 

used with, oil.

Engineering Controls for all 

liquid formulations.

Note if aerial application is 

not permitted or not feasible 

for the end-use product, the 

engineering control 

statements referring to 

pilots or human flaggers 

may be omitted.

“Engineering Controls:”

“Pilots must use an enclosed cockpit that meets the requirements listed in the Worker Protection 

Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(6)].” 

“Human flagging is prohibited. Flagging to support aerial application is limited to use of the Global 

Positioning System (GPS) or mechanical flaggers.”

Precautionary 

Statements: Hazards to 

Humans and Domestic 

Animals (Immediately 

following PPE and 

User Safety 

Requirements.) 

Environmental 

Hazards Statements for 

products labeled for outdoor 

uses other than as a wide 

area mosquito adulticide:

(PR Notice 2005-1 

recommends separating 

labels intended for wide 

area mosquito adulticide

applications.)

“ENVIRONMENTAL HAZARDS”

“This product is toxic to aquatic organisms, including fish and invertebrates. Drift and runoff may 

be hazardous to aquatic organisms in water adjacent to treated areas. This product may contaminate 

water through runoff. This product has a potential for runoff for several weeks after application. 

Poorly draining soils and soils with shallow water tables are more prone to produce runoff that 

contains this product.” 

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

“Do not apply directly to water, to areas where surface water is present or to intertidal areas below

Precautionary 

Statements under 

Environmental Hazards 
5

Description Pyrethrins and PBO Required Labeling Language Placement on Label

the mean high water mark. Do not contaminate water when disposing of equipment wash-waters or 

rinsate.”

 

Environmental 

Hazards Statements for 

products labeled solely for 

use as a wide area mosquito 

adulticide:

(PR Notice 2005-1 

recommends separating 

labels intended for wide 

area mosquito adulticide 

applications.)

“ENVIRONMENTAL HAZARDS”

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. Runoff from treated 

areas or deposition of spray droplets into a body of water may be hazardous to fish and aquatic 

invertebrates.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

“Before making the first application in a season, it is advisable to consult with the state or tribal 

agency with primary responsibility for pesticide regulation to determine if other regulatory 

requirements exist.”

“Do not apply over bodies of water (lakes, rivers, permanent streams, natural ponds, commercial 

fish ponds, swamps, marshes or estuaries), except when necessary to target areas where adult 

mosquitoes are present, and weather conditions will facilitate movement of applied material away 

from the water in order to minimize incidental deposition into the water body. Do not contaminate 

bodies of water when disposing of equipment rinsate or washwaters.”

Precautionary 

Statements under 

Environmental Hazards

Environmental 

Hazards Statements for 

products labeled as a wide 

area mosquito adulticide 

AND is labeled for other 

outdoor uses as well:

(PR Notice 2005-1 

recommends separating 

labels intended for wide 

area mosquito adulticide 

applications.)

“ENVIRONMENTAL HAZARDS for TERRESTRIAL APPLICATIONS”

“This product is toxic to aquatic organisms, including fish and invertebrates. Drift and runoff may 

be hazardous to aquatic organisms in water adjacent to treated areas. This product may contaminate 

water through runoff. This product has a potential for runoff for several weeks after application. 

Poorly draining soils and soils with shallow water tables are more prone to produce runoff that 

contains this product.” 

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Precautionary 

Statements under 

Environmental Hazards
6

Description Pyrethrins and PBO Required Labeling Language Placement on Label

“Except as specified in the directions for use, do not apply directly to water, to areas where surface 

water is present or to intertidal areas below the mean high water mark. Do not contaminate water 

when disposing of equipment wash-waters or rinsate.”

“ENVIRONMENTAL HAZARDS for WIDE AREA MOSQUITO ADULTICIDE 

APPLICATIONS”

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. Runoff from treated 

areas or deposition of spray droplets into a body of water may be hazardous to fish and aquatic 

invertebrates.”

“When applying as a wide area mosquito adulticide, before making the first application in a season, 

it is advisable to consult with the state or tribal agency with primary responsibility for pesticide 

regulation to determine if other regulatory requirements exist.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply when bees are visiting the treatment area, except when applications are made to prevent or 

control a threat to public and/or animal health determined by a state, tribal, or local health or vector 

control agency on the bases of documented evidence of disease causing agents in vector mosquitoes 

or the occurrence of mosquito-borne disease in animal or human populations, or if specifically 

approved by the state or tribe during a natural disaster recovery effort.”

“When applying as a wide area mosquito adulticide, do not apply over bodies of water (lakes, 

rivers, permanent streams, natural ponds, commercial fish ponds, swamps, marshes or estuaries), 

except when necessary to target areas where adult mosquitoes are present, and weather conditions 

will facilitate movement of applied material away from the water in order to minimize incidental 

deposition into the water body. 

Environmental Hazards for 

Products labeled only for 

Indoor Use 

No environmental hazard statement is required for products labeled for indoor use only.

For indoor products packaged in containers equal to or greater than 5 gallons or 50 lbs add 

the following statement:

“Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or 

Precautionary 

Statements under 

Environmental Hazards
7

Description Pyrethrins and PBO Required Labeling Language Placement on Label

other waters unless in accordance with the requirements of a National Pollution Discharge 

Elimination System (NPDES) permit and the permitting authority has been notified in writing prior 

to discharge. Do not discharge effluent containing this product to sewer systems without previously 

notifying the local sewage treatment plant authority. For guidance contact your State Water Board 

or Regional Office of the EPA."

Environmental hazard 

statements on Liquid 

Concentrate consumer

outdoor products (e.g., 

liquids mixed with water by 

the user for a tank sprayer 

or hose-end attachment)

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. To protect the 

environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or 

surface waters. Applying this product in calm weather when rain is not predicted for the next 24 

hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area.

Rinsing application equipment over the treated area will help avoid run off to water bodies or 

drainage systems.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental Hazard 

Statement

Environmental hazard 

statements on Dusts 

consumer outdoor products 

(e.g., for garden or 

ornamental)

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. To protect the 

environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or 

surface waters. Applying this product in calm weather when rain is not predicted for the next 24 

hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental Hazard 

Statement

Environmental hazard 

statements on Ready-to-Use 

consumer outdoor products

(except aerosols and 

foggers)

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. To protect the 

environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or 

surface waters. Applying this product in calm weather when rain is not predicted for the next 24 

hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental Hazard 

Statement
8

Description Pyrethrins and PBO Required Labeling Language Placement on Label

Environmental Hazard 

Statements for Ready to 

Use aerosol and fogger 

consumer outdoor products

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. Do not apply directly 

to or near water. Drift and run-off may be hazardous to fish in water adjacent to treated areas. Do 

not contaminate water when disposing of equipment, washwater, or rinsate. See Directions for Use 

for additional precautions and requirements.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental Hazard 

Statement

Restricted-Entry Interval 

for products with WPS uses 

“Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 

12 hours.”

Directions for Use, 

Agricultural Use 

Requirements Box

Early Entry Personal 

Protective Equipment for 

products with WPS uses 

“PPE required for early entry to treated areas that is permitted under the Worker Protection 

Standard and that involves contact with anything that has been treated, such as soil or water, is:

- coveralls,

- shoes plus socks, and

- chemical-resistant gloves made of any waterproof material.”

Directions for Use, 

Agricultural Use 

Requirements Box

Entry Restrictions 

for products with non-WPS 

uses on the label

Note: This excludes 

products labeled for use 

when people are permitted 

to be present (e.g. wide-area 

mosquito adulticide 

applications, metered 

release devices, and pet 

applications)

Entry Restriction for products applied as a surface spray (does not apply to products applied 

directly to domestic animals): 

“Do not enter or allow others to enter until sprays have dried.”

Entry Restriction for products applied dry:

“Do not enter or allow others to enter until dusts have settled.”

Entry Restriction for products applied as a space spray or as a fog:

“Do not enter or allow others to enter until vapors, mists, and aerosols have dispersed, and the 

treated area has been thoroughly ventilated.”

Total release foggers labeled for indoor use must contain the following entry restriction:

“Wait two (2) hours after application, then open windows, vents and doors for two hours. In an 

If no WPS uses on the 

product label, place the 

appropriate statement 

in the Directions for 

Use Under General 

Precautions and 

Restrictions. If the 

product also contains 

WPS uses, then create a 

Non-Agricultural Use 

Requirements box as 

directed in PR Notice 

93-7 and place the 

appropriate statement 

inside that box.
9

Description Pyrethrins and PBO Required Labeling Language Placement on Label

odor is still detected additional ventilation is required.” 

Note to Registrant: If there is information that justified a change in the duration after application (2 

hours), submit the information to the Agency.

Entry Restrictions for 

products labeled solely for 

use when people are present 

(e.g. wide-area mosquito 

adulticide applications, 

metered release devices, 

and applications to pets)

Note to Registrants: No entry restrictions are required. See below under Use Restrictions for 

further requirements. 

Entry Restrictions for 

products labeled for use 

when people are present 

(e.g. wide-area mosquito 

adulticide applications, 

metered release devices, 

and applications to pets) 

and for use on other sites as 

a directed or space spray.

Products labeled for use as a directed spray (does not apply to products applied directly to 

domestic animals): 

“Except when (insert application method or site that allows people to be present), do not enter or 

allow others to enter until sprays have dried.”

Products labeled for use as a space spray:

“Except when (insert application method or site that allows people to be present), do not enter or 

allow others to enter until vapors, mists, and aerosols have dispersed, and the treated area has been 

thoroughly ventilated.”

Note to Registrant: An example is as follows: Except when applying in a metered release system, 

do not enter or allow others to enter until sprays have dried.

If no WPS uses on the 

product label, place the 

appropriate statement 

in the Directions for 

Use Under General 

Precautions and 

Restrictions. If the 

product also contains 

WPS uses, then create a 

Non-Agricultural Use 

Requirements box as 

directed in PR Notice 

93-7 and place the 

appropriate statement 

inside that box.

General Application 

Restrictions for products 

with WPS or non-WPS uses 

on the label

Note: This excludes 

products that contain any 

“Do not apply this product in a way that will contact workers or other persons, either directly or 

through drift.” 

“Only protected handlers may be in the area during application.”

Place in the Direction 

for Use.
10

Description Pyrethrins and PBO Required Labeling Language Placement on Label

directions for uses when 

people are permitted to be 

present in the treated area 

(e.g. . wide-area mosquito 

adulticide applications, 

metered release devices,

and applications to pets) 

General Application 

Restrictions for products 

with WPS and non-WPS 

uses on the label AND 

contain directions for uses 

when people are permitted 

to be present in the treated 

area (e.g. . wide-area 

mosquito adulticide 

applications, metered 

release devices, and 

applications to pets)

“Except when” (insert application method or site that allows people to be present) “do not apply this 

product in a way that will contact workers or other persons, either directly or through drift.” 

“Except when” (insert application method or site that allows people to be present) “only protected 

handlers may be in the area during application.”

Place in the Direction 

for Use. 

General Application 

Restrictions for products 

labeled for use solely when 

people are permitted to be 

present in the treated area 

(e.g. wide-area mosquito 

adulticide applications, 

metered-release devices, 

and applications to pets)

Note to Registrants: No entry restrictions are required. See below under Use Restrictions for 

further requirements. 

Place in the Direction 

for Use. 

Other Application 

Restrictions

Note to Registrants: Delete any reference to tolerance exemptions on labels.

In addition add the following restrictions depending on the registered product uses and formulation:

Directions for Use 

under Use Restrictions
11

Description Pyrethrins and PBO Required Labeling Language Placement on Label

All formulations labeled or intended for outdoor residential uses:

“Do not make applications during rain.”

Wettable powder formulations:

“Do not apply this product as a dust.”

“Do not apply in forestry areas.”

Dust formulations:

“Aerial applications are prohibited.”

“Applications with power duster equipment are prohibited.”

“Only apply as a spot treatment to areas no greater than 3 feet by 3 feet per room.”

 

Products labeled for use as a space spray excluding metered release devices:

“Do not remain in treated area. Exit area immediately and remain outside the treated area until 

aerosols, vapors, and/or mists have dispersed.”

Products labeled for spray applications to plants:

“Do not wet plants to point of runoff or drip.”

Products labeled for spray applications to articles:

“Do not wet articles to point of runoff or drip.”

“Do not use treated article until spray has dried.”

Products labeled for applications to clothing articles:

“Dry clean treated clothes before wearing.”

Products labeled for dip applications to empty containers:

“Do not use treated article before it is dry.”

Products labeled for crack and crevice, surface or space spray, fogging or dust applications 
12

Description Pyrethrins and PBO Required Labeling Language Placement on Label

indoors excluding metered release devices: 

“Remove or cover exposed food and drinking water before application.”

“Remove or cover dishes, utensils, food processing equipment, and food preparation surfaces, or 

wash them before use.” 

Liquid, Dust, and Ready-To-Use products intended for outdoor residential use:

“Do not water the treated area to the point of run-off.”

Products labeled for applications to non-residential indoor sites:

“Do not use in aircraft cabins except in compliance with PR Notice 96-3.” 

“When used in dairy barns or facilities: Close milk bulk tank lids to prevent contamination from 

spray and from dead or falling insects. Remove or cover milking utensils before application. Wash 

teats of animals before milking.”

Products labeled for use in food handling and processing facilities excluding metered release 

devices:

“Do not make space spray applications when facility is in operation.”

“Prior to space spray applications, cover or remove food.”

“Prior to space spray applications, cover food processing surfaces or clean after treatment and 

before use.”

Products labeled for use around or near floor drains. Products labeled for use in drains or 

sewers are excluded from this label requirement: “Do not apply directly into sewers or drains, or 

to any area like a gutter where drainage to storm sewers, water bodies, or aquatic habitat can occur. 

Do not allow the product to enter any drain during or after application.”

Products labeled for use in drains or sewers:

“Except when applying to sewers or drains as instructed on this label, do not apply directly to 

sewers or drains, or to any area like a gutter where drainage to sewers, storm drains, water bodies, 

or aquatic habitat can occur.”

Residential Outdoor Surface and Space Sprays, except for outdoor fogging devices:

“All outdoor applications must be limited to spot or crack-and-crevice treatments only, except for 

the following permitted uses:
13

Description Pyrethrins and PBO Required Labeling Language Placement on Label

(1) Treatment to soil or vegetation around structures;

(2) Applications to lawns, turf, and other vegetation;

(3) Applications to building foundations, up to a maximum height of 3 feet.

Other than applications to building foundations, all outdoor applications to impervious surfaces 

such as sidewalks, driveways, patios, porches and structural surfaces (such as windows, doors, and 

eaves) are limited to spot and crack-and-crevice applications, only.”

Use-Specific Application 

Restrictions

(Note: The maximum 

allowable application rate 

and maximum allowable 

seasonal rate must be listed 

as pounds or gallons of 

formulated product per acre, 

not just as pounds active 

ingredient per acre. 

All rates must be expressed 

in terms the applicator can 

use in order to arrive at the 

maximum application rate. 

For example, for sprays 

rates must specify the 

duration of spray to a 

specific area, i.e., spray for 

X seconds to a space Y feet 

by Z feet.)

Note: See Appendix A for a complete list of application rates and restrictions that are eligible 

for reregistration. 

Note to Registrant: In addition, these label statements should be deleted from all products 

registered for food handling and processing facilities: 

“Except in Federally inspected meat and poultry plants, food processing operations may 

continue when the product is applied as a general surface spray/crack and crevice spray with 

care and in accordance with the directions and precautions on the label, at a maximum rate of 

X pounds of product per 1000 square feet.” 

These rate changes must be updated on all products:

The maximum PBO rate for indoor crack and crevice spray is 0.56 lbs ai/1000 square feet.

Formulated indoor space spray products eligible for reregistration must not contain more than 0.05 

lbs ai/16 ounce can.

Formulated pet spray products eligible for reregistration must not contain more than 10 % piperonyl 

butoxide. 

Formulated pet spray products eligible for reregistration must not contain more than 0.2 % 

pyrethrins. 

The maximum space spray rate for food handling establishments is 0.0033 lbs pyrethrins per 1000 

cubic feet.

Directions for Use 

under Use Restrictions
14

Description Pyrethrins and PBO Required Labeling Language Placement on Label

The maximum space spray rate for residential areas is 0.00033 lbs pyrethrins per 1000 cubic feet.

The maximum space spray rate for post-harvest applications to fruits, vegetables and copra is 0.001 

lbs pyrethrins per 1000 cubic feet.

The maximum space spray rate for post-harvest application to fruits, vegetables, and nuts is 0.01 lbs 

PBO per 1000 cubic feet.

Application Restrictions for 

products used in Metered 

Release Devices

Note to Registrants: Delete nurseries, day care centers, schools, hospitals, and nursing homes as 

registered use sites on all product labels for this use pattern.

Add the following statements:

“Not for use in Residential areas.”

“Do not use in nurseries or rooms where infants, ill, or aged persons are confined.”

“Do not place metering device directly over or within 8 feet of exposed food, dishes, utensils, food 

processing equipment, and food handling or preparation.”

“Do not install within 3 feet of air vents.”

“Carefully follow directions for the dispenser unit when installing the dispenser and replacing cans 

or conducting maintenance.” 

“The maximum application rate for metered release devices is 0.00046 lb pyrethrin per 1000 cubic 

feet.” 

Directions for Use 

under Use Restrictions

Indoor Misting Systems 

Used in Commercial Barns, 

Stables, and Animal 

Quarters

“Directions for use in commercial animal premise automatic misting systems”

“Not for use in outdoor residential misting systems (indoor or outdoor).”

“Do not apply this product in barns or stables where animals intended for slaughter or human 

consumption will be maintained.”

“Do not apply when food, feed, and/or water is present.”

“When using this product, installers and service technicians must comply with the license, 

certification, or registration requirements of the state(s), tribe(s), or local authority(ies) where they 

Directions for Use 

under Use Restrictions
15

Description Pyrethrins and PBO Required Labeling Language Placement on Label

are installed.” 

“When applying via a remote activation device, do not apply when people and pets are present. If 

possible, when applying via automatic timer, set the timing for application when people and pets 

are unlikely to be present.”

“Direct nozzles to spray towards the target area and away from areas where people are typically 

present.”

“Do not use in an evaporative cooling system.”

“Do not use in misters located within 3 feet of air vents, air conditioner units, or windows.”

“If used in a system with a reservoir tank for the end use dilution, the system reservoir tank must be 

locked. Securely attach the end use pesticide label and a dilution statement to the system reservoir 

tank in a weather protected area or plastic sleeve. The dilution statement must be phrased as 

follows: this container holds __ parts [product name] to __ parts water”

“If used in a direct injection system, the pesticide container must be locked. Securely attach the 

end use label to the pesticide container in a weather protected area or plastic sleeve.” (These 

instructions not applicable to wettable powder products). 

“This product must only be used in systems that have been calibrated to apply no more than the 

maximum application rate of” [insert product application rate]. 

Note to registrant: Also express this application rate as pounds or gallons of end-use product 

formulation.

Application Restrictions for 

products used in Outdoor 

Metered Release Devices

Outdoor Metered Release Devices

“Directions for use in outdoor metered release devices:”

“If the device works on an automatic timer, set the timing for application when people, pets, and/or

food are unlikely to be present.”

“If the device works when a person operates a remote activation device, then application of this 

pesticide when people, pets, and food are/or present is prohibited.”

Directions for Use 

under Use Restrictions
16

Description Pyrethrins and PBO Required Labeling Language Placement on Label

“Direct nozzle to spray towards the target area and away from areas where people are typically 

present.” 

“The pesticide container must be locked.” 

“Do not install within 3 feet of air vents, air conditioner units, or windows.”

“Carefully follow directions for the dispenser unit when installing the dispenser and replacing cans 

or conducting maintenance.” 

Use-Specific Application 

Restrictions for all liquid 

and wettable powder labels 

(Outdoor residential misting 

system requirement)

(Note: The maximum 

allowable application rate 

and maximum allowable

seasonal rate must be listed 

as pounds or gallons of 

formulated product per acre, 

not just as pounds active 

ingredient per acre.)

Outdoor Residential Misting Systems

Products not intended for use in outdoor residential misting systems must contain the 

following statement: 

“Not for use in outdoor residential misting systems.”

Products intended for use in outdoor residential misting systems must contain the following 

statements: 

“Directions for use in outdoor residential misting systems:”

“When using this product installers and service technicians must comply with the license, 

certification, or registration requirements of the state(s), tribe(s), or local authority(ies) where they 

are installed.” 

“If the system works on an automatic timer, set the timing for application when people, pets, and 

food are unlikely to be present.”

“If the system works when a person operates a remote activation device, then application of this 

pesticide when people, pets, and food are present is prohibited.”

“Do not use in an evaporative cooling system.”

Directions for Use 

under Use Restrictions
17

Description Pyrethrins and PBO Required Labeling Language Placement on Label

“Direct nozzles to spray towards the target area and away from swimming pools, water bodies, or 

eating and cooking areas.” 

“Do not set nozzles to direct mist near outside air condition systems or other home air intakes.”

“If used in a system with a reservoir tank for the end use dilution, the system reservoir tank must be 

locked. Securely attach the end use pesticide label and a dilution statement to the system reservoir 

tank in a weather protected area or plastic sleeve. The dilution statement must be phrased as 

follows: this container holds __ parts [product name] to __ parts water”

“If used in a direct injection system, the pesticide container must be locked. Securely attach the end 

use label to the pesticide container in a weather protected area or plastic sleeve.” (These 

instructions not applicable to wettable powder products). 

“Contact the system manufacture for guidance or assistance to ensure compliance with the 

following requirement:”

“This product must only be used in systems that have been calibrated to apply no more than the 

maximum application rate of” [insert product application rate that is equal to 0.00011 lbs pyrethrins 

per 1000 cubic feet per day or 0.00058 lbs piperonyl butoxide per 1000 cubic feet per day, 

whichever is lower]. 

Note to registrant: Also express this application rate as pounds or gallons of end-use product 

formulation. 

Use-Specific Application 

Restrictions for products 

labels for 

Mosquito Adulticide 

Application by ground or 

air.

(Note: The maximum 

allowable application rate 

and maximum allowable 

“For use by federal, state, tribal, or local government officials responsible for public health or 

vector control, or by persons certified in the appropriate category or otherwise authorized by the 

state or tribal lead pesticide regulatory agency to perform adult mosquito control applications, or by 

persons under their direct supervision.”

The maximum application rate for wide area mosquito adulticide applications is 0.0025 lbs 

pyrethrin/acre, or 0.025 lbs piperonyl butoxide/acre, whichever is lower. When targeting Aedes 

Taeirorhynchus and other difficult species applications may be made up to 0.008 lbs 

pyrethrin/acre/day, or 0.08 lbs piperonyl butoxide/acre/day, whichever is lower. 

Directions for Use 

under Use Restrictions
18

Description Pyrethrins and PBO Required Labeling Language Placement on Label

seasonal rate must be listed 

as pounds or gallons of 

formulated product per acre, 

not just as pounds active 

ingredient per acre.)

“Do not apply more than 0.2 lbs pyrethrin/acre/year, or 2.0 lbs piperonyl butoxide/acre/year, 

whichever is lower, in any treated area More frequent treatments may be made to prevent or 

control a threat to public and/or animal health determined by a state, tribal, or local health or vector 

control agency on the basis of documented evidence of disease causing agents in vector mosquitoes 

or the occurrence of mosquito-borne disease in animal or human populations, or if specifically 

approved by the state or tribe during a natural disaster recovery effort.”

WIND SPEED:

“Apply only when wind speed is greater than or equal to 1 mph.”

“Ground-based applications for wide-area mosquito abatement application:

Spray equipment must be adjusted so that the volume median diameter is less than 30 microns (Dv 

0.5 < 30 μm) and that 90% of the spray is contained in droplets smaller than 50 microns (Dv 0.9 < 

50 μm). Directions from the equipment manufacturer or vendor, pesticide registrant or a test 

facility using a lazer-based measurement instrument must be used to adjust equipment to produce 

acceptable droplet size spectra. Application equipment must be tested at least annually to confirm 

that pressure at the nozzle and nozzle flow rate(s) are properly calibrated.”

“Aerial applications for wide-area mosquito abatement application:

Spray equipment must be adjusted so that the volume median diameter produced is less than 60 

microns (Dv 0.5 < 60 μm) and that 90% of the spray is contained in droplets smaller than 80 

microns (Dv 0.9 < 80 μm). The effects of flight speed, and for non-rotary nozzles, nozzle angle on 

the droplet size spectrum must be considered. Directions from the equipment manufacturer or 

vendor, pesticide registrant or a test facility using a wind tunnel and laser-based measurement 

instrument must be used to adjust equipment to produce acceptable droplet size spectra. 

Application equipment must be tested at least annually to confirm that pressure at the nozzle and 

nozzle flow rate(s) are properly calibrated.” 

RELEASE HEIGHT for AERIAL:

“Fixed wing:”

“Apply using a nozzle height of no less than 100 feet above the ground or canopy.”
19

Description Pyrethrins and PBO Required Labeling Language Placement on Label

“Rotary wing:”

“Apply using a nozzle height of no less than 75 feet above the ground or canopy.”

Spray Drift Label Language 

for all products labeled for 

outdoor applications to 

agricultural use sites 

“SPRAY DRIFT MANAGEMENT for AGRICULTURE CROPS”

“Avoiding spray drift at the application site is the responsibility of the applicator and the grower. 

The interactions of many equipment and weather-related factors determine the potential for spray 

drift. The applicator and the grower are responsible for considering all these factors when making 

decisions.”

“Do not apply at wind speeds greater than 10 mph at the application site.”

“Do not make any type of application into temperature inversions.”

“Apply as a medium or coarser spray (ASABE standard 572).”

“Additional requirements for aerial applications:”

“Do not release spray at a height greater than 10 feet above the ground or crop canopy.”

“The boom length must not exceed 75% of the wingspan or 90% of the rotor blade diameter.”

“Aerial applicators must consider flight speed and nozzle orientation in determining droplet size.”

“When applications are made with a cross-wind, the swath will be displaced downwind. The 

applicator must compensate for this displacement at the downwind edge of the application area by 

adjusting the path of the aircraft upwind.”

“Additional requirements for ground applications:”

“Do not release spray at a height greater than 4 feet above the ground or crop canopy.”

“Additional requirements for airblast applications:”

“Direct sprays into the canopy.”

Directions for Use 

under General 

Precautions and 

Restrictions
20

Description Pyrethrins and PBO Required Labeling Language Placement on Label

“Turn off outward pointing nozzles at row ends and when spraying outer rows.”

Products Primarily Used by Consumers/Homeowners

[Note: For products with both occupational and consumer homeowner uses, the more restrictive language from these labeling tables must be used.]

Entry Restrictions 

for products except those 

products that contain any 

directions for uses when 

people are permitted to be 

present in the treated area 

(e.g. . applications to pets)

Entry Restriction for products applied as a spray except for sprays applied directly to 

domestic animals: 

“Do not allow adults, children, or pets to enter the treated area until sprays have dried.”

Entry Restriction for products applied dry:

“Do not allow adults, children, or pets to enter the treated area until dusts have settled.”

Entry Restriction for products applied as a space spray or as a fog:

“Do not allow adults, children, or pets to enter until vapors, mists, and aerosols have dispersed, and 

the treated area has been thoroughly ventilated.”

Total release foggers labeled for indoor use must contain the following entry restriction:

“Wait two (2) hours after application, then open windows, vents and doors for two hours. In an 

odor is still detected additional ventilation is required.” 

Note to Registrant: If there is information that justified a change in the duration after application (2 

hours), submit the information to the Agency.

Directions for use 

under General 

Precautions and 

Restrictions

Entry Restrictions for 

products that only contain 

directions for uses when 

people are permitted to be 

present (e.g. pet

applications)

Note to Registrants: No entry restrictions are required. See below under Use Restrictions for 

further requirements. 

Directions for use 

under General 

Precautions and 

Restrictions

Entry Restrictions for Products labeled for use as a surface spray (does not apply to products applied directly to Directions for use 
21

Description Pyrethrins and PBO Required Labeling Language Placement on Label

products that contain 

directions for uses when 

people are permitted to be 

present in the treated area 

(e.g. applications to pets) 

AND for use on other sites 

as a surface spray.

domestic animals): 

“Except when (insert application method or site that allows people to be present), do not allow

adults, children, or pets to enter until sprays have dried.”

Note to Registrant an example is as follows: Except when applying directly to pets, do not allow

adults, children, or pets to enter until sprays have dried.

under General 

Precautions and 

Restrictions

General Application 

Restrictions for all products 

except those that contain 

any directions for uses 

when people are permitted 

to be present in the treated 

area (e.g., applications to 

pets)

“Do not apply this product in a way that will contact adults, children, or pets, either directly or 

through drift.” 

“Remove pets, birds, and cover fish aquariums before spraying.”

Place in the Direction 

for Use 

General Application 

Restrictions for products 

that only contain directions 

for uses when people are 

permitted to be present (e.g. 

pet applications)

Note to Registrants: No entry restrictions are required. See below under Use Restrictions for 

further requirements. 

Place in the Direction 

for Use 

General Application 

Restrictions for products 

that contain directions for 

uses when people are 

permitted to be present in 

the treated area (e.g. 

applications to pets) AND 

for use on other sites as a 

surface spray.

“Except when (insert application method or site that allows people to be present), do not apply this 

product in a way that will contact adults, children, or pets, either directly or through drift.” 

Note to Registrant an example is as follows: Except when applying to pets, do not apply this 

product in a way that will contact adults, children, or pets, either directly or through drift.

Place in the Direction 

for Use 

Environmental hazard “This pesticide is toxic to aquatic organisms, including fish and invertebrates. To protect the Environmental Hazard 
22

Description Pyrethrins and PBO Required Labeling Language Placement on Label

statements on Liquid 

Concentrate consumer

outdoor products (e.g., 

liquids mixed with water by 

the user for a tank sprayer 

or hose-end attachment)

environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or 

surface waters. Applying this product in calm weather when rain is not predicted for the next 24 

hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area.

Rinsing application equipment over the treated area will help avoid run off to water bodies or 

drainage systems.

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Statement

Environmental hazard 

statements on Dusts 

consumer outdoor products 

(e.g., for garden or 

ornamental)

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. To protect the 

environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or 

surface waters. Applying this product in calm weather when rain is not predicted for the next 24 

hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental Hazard 

Statement

Environmental hazard 

statements on Ready-toUse consumer outdoor 

products (except aerosols 

and foggers)

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. To protect the 

environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or 

surface waters. Applying this product in calm weather when rain is not predicted for the next 24 

hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental Hazard 

Statement

Environmental Hazard 

Statements aerosol and 

fogger consumer outdoor 

products

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. Do not apply directly 

to or near water. Drift and run-off may be hazardous to fish in water adjacent to treated areas. Do 

not contaminate water when disposing of equipment, washwater, or rinsate. See Directions for Use 

for additional precautions and requirements.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

Environmental Hazard 

Statement
23

Description Pyrethrins and PBO Required Labeling Language Placement on Label

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Other Application 

Restrictions (as applicable)

Note to Registrants: Delete any reference to tolerance exemptions on labels.

In addition add the following restrictions depending on the registered product uses and formulation:

All formulations labeled or intended for outdoor residential uses:

“Do not make applications during rain.”

Wettable powder formulations:

“Do not apply this product as a dust.”

Dust formulations:

“Aerial applications are prohibited.”

“Only apply as a spot treatment to areas no greater than 3 feet by 3 feet per room.”

 

Products labeled for use as a space spray:

“Do not remain in treated area. Exit area immediately and remain outside the treated area until 

aerosols, vapors, and/or mists have dispersed.”

Products labeled for spray applications to plants:

“Do not wet plants to point of runoff or drip.”

Products labeled for spray applications to articles:

“Do not wet articles to point of runoff or drip.”

“Do not use treated article until spray has dried.”

Products labeled for applications to clothing articles:

“Dry clean treated clothes before wearing.”

Directions for Use 

under Use Restrictions
24

Description Pyrethrins and PBO Required Labeling Language Placement on Label

Products labeled for dip applications to empty containers:

“Do not use treated article before it is dry.”

Products labeled for crack and crevice, surface or space spray, fogging or dust applications 

indoors: 

“Remove or cover exposed food and drinking water before application.”

“Remove or cover dishes, utensils, food processing equipment, and food preparation surfaces, or 

wash them before use.” 

Liquid, Dust, and Ready-To-Use products intended for outdoor residential use:

“Do not water the treated area to the point of run-off.”

Products labeled for use around or near floor drains. Products labeled for use in drains or 

sewers are excluded from this label requirement: “Do not apply directly into sewers or drains, or 

to any area like a gutter where drainage to storm sewers, water bodies, or aquatic habitat can occur. 

Do not allow the product to enter any drain during or after application.”

Products labeled for use in drains or sewers:

“Except when applying to sewers or drains as instructed on this label, do not apply directly to 

sewers or drains, or to any area like a gutter where drainage to sewers, storm drains, water bodies, 

or aquatic habitat can occur.”

Residential Outdoor Surface and Space Sprays, except for outdoor fogging devices:

“All outdoor applications must be limited to spot or crack-and-crevice treatments only, except for 

the following permitted uses:

(1) Treatment to soil or vegetation around structures;

(2) Applications to lawns, turf, and other vegetation;

(3) Applications to building foundations, up to a maximum height of 3 feet. 

Other than applications to building foundations, all outdoor applications to impervious surfaces 

such as sidewalks, driveways, patios, porches and structural surfaces (such as windows, doors, and 

eaves) are limited to spot and crack-and-crevice applications, only.”
25

Description Pyrethrins and PBO Required Labeling Language Placement on Label

Residential Use Restriction

(Note: The maximum 

allowable application rate 

and maximum allowable 

seasonal rate must be listed 

as pounds or gallons of 

formulated product per acre 

or per square feet or per 

cubic feet, not just as 

pounds active ingredient per 

unit area.)

Note: See Appendix A for a complete list of application rates and restrictions that are eligible 

for reregistration. 

These rate changes must be updated on all products:

The maximum PBO rate for indoor crack and crevice spray is 0.56 lbs ai/1000 square feet.

Formulated indoor space spray products eligible for reregistration must not contain more than 0.05 

lbs ai/16 ounce can.

Formulated pet spray products eligible for reregistration must not contain more than 10 % piperonyl 

butoxide. 

Formulated pet spray products eligible for reregistration must not contain more than 0.2 % 

pyrethrins. 

The maximum space spray rate for residential areas is 0.00033 lbs pyrethrins per 1000 cubic feet.

The maximum space spray rate for post-harvest applications to fruits, vegetables and copra is 0.001 

lbs pyrethrins per 1000 cubic feet.

The maximum space spray rate for post-harvest application to fruits, vegetables, and nuts is 0.01 lbs 

PBO per 1000 cubic feet.

Directions for Use 

under Use Restrictions

Application Restrictions for 

products used in Outdoor 

Metered Release Devices

Outdoor Metered Release Devices

“Directions for use in outdoor metered release devices:”

“If the device works on an automatic timer, set the timing for application when people, pets, and/or

food are unlikely to be present.”

“If the device works when a person operates a remote activation device, then application of this 

Directions for Use 

under Use Restrictions
26

Description Pyrethrins and PBO Required Labeling Language Placement on Label

pesticide when people, pets, and food are/or present is prohibited.”

“Direct nozzle to spray towards the target area and away from areas where people are typically 

present.” 

“The pesticide container must be locked.” 

“Do not install within 3 feet of air vents, air conditioner units, or windows.”

“Carefully follow directions for the dispenser unit when installing the dispenser and replacing cans 

or conducting maintenance.” 

Use-Specific Application 

Restrictions for all liquid 

and wettable powder labels 

(Outdoor residential misting 

system requirement)

Note to registrant: Also 

express this application rate 

as pounds or gallons of enduse product formulation. 

Outdoor Residential Misting Systems

Products not intended for use in outdoor residential misting systems must contain the 

following statement: 

“Not for use in outdoor residential misting systems.”

Products intended for use in outdoor residential misting systems must contain the following 

statements: 

“Directions for use in outdoor residential misting systems:”

“When using this product installers and service technicians must comply with the license, 

certification, or registration requirements of the state(s), tribe(s), or local authority(ies) where they 

are installed.” 

“If the system works on an automatic timer, set the timing for application when people, pets, and 

food are unlikely to be present.”

“If the system works when a person operates a remote activation device, then application of this 

pesticide when people, pets, and food are present is prohibited.”

Directions for Use 

under Use Restrictions
27

Description Pyrethrins and PBO Required Labeling Language Placement on Label

“Do not use in an evaporative cooling system.”

“Direct nozzles to spray towards the target area and away from swimming pools, water bodies, or 

eating and cooking areas.” 

“Do not set nozzles to direct mist near outside air condition systems or other home air intakes.”

“If used in a system with a reservoir tank for the end use dilution, the system reservoir tank must be 

locked. Securely attach the end use pesticide label and a dilution statement to the system reservoir 

tank in a weather protected area or plastic sleeve. The dilution statement must be phrased as 

follows: this container holds __ parts [product name] to __ parts water”

“If used in a direct injection system, the pesticide container must be locked. Securely attach the end 

use label to the pesticide container in a weather protected area or plastic sleeve.” (These 

instructions not applicable to wettable powder products). 

“Contact the system manufacture for guidance or assistance to ensure compliance with the 

following requirement: 

“This product must only be used in systems that have been calibrated to apply no more than the 

maximum application rate of” [insert product application rate that is equal to 0.00011 lbs pyrethrins 

per 1000 cubic feet per day, or 0.00058 lbs piperonyl butoxide per 1000 cubic feet per day, 

whichever is lower]. 

Note to registrant: Also express this application rate as pounds or gallons of end-use product 

formulation.

1 PPE that is established on the basis of Acute Toxicity of the end-use product must be compared to the active ingredient PPE in this document. In the case of multiple 

active ingredients, the more protective PPE must be placed on the product labeling. For guidance on which PPE is considered more protective, see PR Notice 93-7.