Initial to indicate certification as to information on this page (full text of certification is on page one). Date INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary. 2. Case # and Name 3. Date and Type of DCI and Number

4. EPA Product Registration 5. I wish to cancel this product registration voluntarily 6. Generic Data 7. Product Specific Data 6a. I am claiming a Generic Data Exemption because I obtain the active ingredient from the source EPA registration number listed below. 6b. I agree to satisfy Generic Data Requirements as indicated on the attached form entitled "Requirements Status and Registrant's Response." 7a. My product is an MUP and I agree to satisfy the MUP requirement on the attached form entitled "Requirements Status and Registrant's Response." 7b. My product is an EUP and I agree to satisfy the EUP requirement on the attached form entitled "Requirements Status and Registrant's Response." OMB Approval 2070-0174

1. Company Name and Address N/A - Azoxystrobin Chemical # and Name: 128810 Azoxystrobin 09-Nov-2011 GENERIC ID # GDCI-128810-892 

### United States Environmental Protection Agency

Washington, D.C. 20460 DATA CALL-IN RESPONSE 1 Page of 1

8. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law. Signature and Title of Company's Authorized Representative ______________________________________________________ 10. Name of Company N/A N/A

9. Date

11. Phone NumberInitial to indicate certification as to information on this page (full text of certification is on page one) 13. Phone Number 10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.
12. Name of Company 11. Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________

Applicator Exposure Data Requirements (Conventional Chemical)

Environmental Fate Data Requirements (Conventional Chemical)

Post-Application Exposure Data Requirements (Conventional Chemical) 875.1300 875.1400 875.1600

835.4300 835.6200

875.2300 875.2800 Inhalation exposure--outdoor

Inhalation exposure--indoor Application exposure monitoring data reporting

Aerobic aquatic metabolism Aquatic field dissipation

Indoor surface residue dissipation Description of human activity N/A - Azoxystrobin Chemical # and Name: 128810 Azoxystrobin 09-Nov-2011 GENERIC ID # GDCI-128810-892

U,GG,C,A,T,K U,GG,C,A,T,K U,GG,C,A,T,K

U,GG,C,A,T,K U,GG,C,A,T,K

U,GG,C,A,T,K U,GG,C,A,T,K TEP TEP TEP

TGAI TEP

TEP TEP 24 24 12

24 24

24 24 1 of Page

(6, 15) (5, 15) (7, 9)

(13) (4, 12)

(10, 15) (2) Y Y N

N N

Y N 2Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Residue Chemistry Data Requirements for Food Uses (Conventional Chemical)

Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical) 860.1500 860.1500

850.2100

870.7800 875.2700 Crop field trials (BLACKBERRY)

Crop field trials (CRANBERRY)

Avian acute oral toxicity test
Immunotoxicity Product Use Information N/A - Azoxystrobin Chemical # and Name: 128810 Azoxystrobin 09-Nov-2011 GENERIC ID # GDCI-128810-892

U,GG,C,A,T,K U,GG,C,A,T,K

U,GG,C,A,T,K

U,GG,C,A,T,K U,GG,C,A,T,K TEP TEP

EP; PAI; TGAI

TGAI TEP 24 24

24

12 12 2 of Page

(1) (14)

(11, 16)

(3, 8) N

N

N

N N 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Azoxystrobin GDCI-128810-892

1 2

3

4

5 6 7
8 9 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Two additional field trials are required for the caneberry subgroup; one trial should be conducted in Region 1 or 2, and one trial should be conducted in Region 5 or 6. Blackberry or raspberry field trial studies would be acceptable. The Agency is requiring more information on the end product user itself for the antimicrobial uses of azoxystrobin. The Agency needs to know how users are contacting the product and in what ways, including the frequency or duration of contact. This information would help the Agency ensure that the PPE requirements are adequate. If the registrant elects to be descriptive, then no protocol is needed. However, if the registrant conducts a study to depict the behavior/use patterns, then a protocol will be required and may potentially need to be reviewed by the Human Studies Review Board. The Agency is requiring information regarding the end use/end use applications of the antimicrobial uses of azoxystrobin (i.e., paints, plastics, preservatives, adhesives, etc.). The Agency requires data/information regarding how the registered products are used, along with the actual types of consumer goods that are or can be manufactured with azoxystrobin. For instance, the Agency is interested in what kinds of plastics azoxystrobin is used in so that the Agency can determine the necessity and types of exposure, or with respect to paints, whether azoxystrobin is used industrially, residentially, commercially, etc. This type of information will help the Agency avoid making generic assumptions. Requirement is for water environmental chemistry analytical method only; the aquatic field dissipation study is not required. The submission must include results of a successful confirmatory method trial by an independent laboratory. The submission must include a statement of no data confidentiality. Test standards and procedures for independent laboratory validation are available as addenda to the guideline for this requirement. Inhalation exposure data are needed for both residential and occupational use scenarios for the antimicrobial uses of azoxystrobin. The study design for each scenario (indoor and outdoor) should consider the use pattern likley to result in the greatest exposure. Inhalation exposure data are needed for both residential and occupational use scenarios for the antimicrobial uses of azoxystrobin. The study design for each scenario (indoor and outdoor) should consider the use pattern likely to result in the greatest exposure. In accordance with 40 CFR 158.1020, OPPTS Guideline 875.1600 is required to accompany 875.1300 (Inhalation Outdoor Exposure) and 875.1400 (Inhalation Indoor Exposure). When both inhalation exposure GLNs are listed, the registrant is only required to perform one of the two inhalation exposure tests (that which is expected to result in the greatest exposure). A protocol must be submitted for review and approval by the Agency prior to initiating this study. The draft protocol must be submitted to the Agency within 90 days of receipt of this DCI. If the registrant elects to be descriptive, then no protocol is needed. However, if the registrant conducts a study to depict the behavior/use patterns, then a protocol will be required and may potentially need to be reviewed by the Human Studies Review Board. Guideline refers to reporting and report format. Case # and Name: DCI Number: 1 Page: of

Footnotes: The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement. Use Categories Key: A - Terrestrial food crop C - Terrestrial nonfood crop K - Residential T - Commercial, institutional and industrial premises and equipment U - Residential and public access premises GG - Low Exposure Antimicrobial 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Azoxystrobin GDCI-128810-892

10

11 12

13 14 15 16 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Due to plastic antimicrobial uses for azoxystrobin, the Agency assumes this can potentially be incorporated into children's toys (and therefore presenting potential exposure via the oral route). This study should provide chemical specific migration data to quantify the amount of azoxystrobin that may potentially leach out and become available. Please note that the registrant may elect to implement label language to restrict the manufacturing of toys, and if this is pursued, then this guideline study will no longer be required. Data is needed on passerine species. An environmental chemistry method for azoxystrobin residues in water was submitted by the registrant. However, an independent validation of this method was not submitted with the method. Therefore, an independent laboratory validation of the submitted analytical method for azoxystrobin residues in water is required to support monitoring for azoxystrobin residues and to evaluate submitted environmental fate and ecological effects data. The method submitted also did not include the Z-isomer of azoxystrobin. Therefore, an environmental chemistry method for azoxystrobin, and residues of concern, in water with independent laboratory validation of the method, are required. An aerobic aquatic metabolism study is required for both azoxystrobin and its degradate, z-isomer (compound 9). An additional cranberry field trial study using the WDG formulation is required in either Region 1 or 5. A study protocol should be submitted for Agency approval, prior to study initiation. A protocol is recommended to be submitted to the Agency for comment before study initiation. Before developing the protocol, it is also recommended that a range-finding test is conducted first to establish the concentrations that will be used in the test. If the concentrations cannot be established due to regurgitation, the registrant will need to show how they will test up to the maximum concentration required for an avian acute oral toxicity test with passerines. Case # and Name: DCI Number: 2 Page: of 2

### United States Environmental Protection Agency Washington, D.C. 20460 LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE N/A - Azoxystrobin Case # and Name: 1 Page: of 1

100 SYNGENTA CROP PROTECTION, LLC Co. Nr. Company Name Agent For Company 410 SWING ROAD, P.O. Box 18300 Address City ZIP GREENSBORO 274198300 OMB Approval 2070-0174

State NC DCI Number: GDCI-128810-892

# LINKS TO FORMS: The pesticide registration forms that are listed below can be found at: http://www.epa.gov/opprd001/forms/ Link to C onfidential Statement of Formula and Instructions (Form # 8570 -4 

# ) http://www.epa.gov/opprd001/forms/8570 - 4.pdf C ertification of Attempt to Enter Into an Agreement With Registrants for Development of Data (Form # 8570 - 32 

# ) http://www.epa.gov/opprd001/forms/8570 - 32.pdf
C ertification With Respect to Citation of Data (Form # 8570 - 34 

# ) http://www.epa.gov/opprd001/forms/8570 - 34.pdf