**EXHIBIT10.22**

** **

*****TextOmitted and Filed Separately**

**with theSecurities and Exchange Commission.**

**ConfidentialTreatment Requested**

**Under 17C.F.R. Sections 200.80(b)(4)**

**and240.24b-2.**

 

**AMENDMENTNO. 2 TO THE**

**LICENSEAGREEMENT CONTROL NO. 2007-04-0173**

**BETWEENSENOMYX INC. AND**

**THEREGENTS OF THE UNIVERSITY OF CALIFORNIA**

 

Theparties to the License Agreement with an effective date of October 11,2006, as amended by that certain First Amendment dated February 7, 2007(as amended, the “Agreement”) cited above wish to amend such Agreement,effective as of November 20,  2009 (“AmendmentNo.2  Effective Date”) as set forth belowto incorporate additional intellectual property.

 

Now,therefore, it is hereby agreed as follows:

 

1.  The cover page is amended by the additionof the case “2001-F10”.

 

2.  The UCSD Disclosure Dockets listed in thefirst RECITAL are amended by the addition of the case listed below:

 

*“2001-F10   2001-510 * [...***...]*”*

 

3.  The seventh RECITAL is amended to read:

 

*WHEREAS*, under the terms of the interinstitutionalagreements between NIH and UNIVERSITY (UC Control No. 2000-18-0542 and UCControl No. 2010-18-018: “NIH Interinstitutional Agreement”), UNIVERSITYis granted the exclusive right to manage the inventions on behalf of bothparties;

 

4.  Exhibit B is replaced in its entirety bythe revised Exhibit B as attached.

 

Except for the changesmade above, all of the other terms and conditions in the Agreement between theparties shall remain in effect.

 

This amendment may beexecuted by facsimile or electronic copy and in two (2) or morecounterparts, each of which shall be deemed an original and all of whichtogether shall constitute but one and the same instrument.

 
| **Senomyx, Inc.** | ** **                        | **THE REGENTS OF THE UNIVERSITY  OF CALIFORNIA, SAN DIEGO CAMPUS** |
|------------------------|-----------------------------------|--------------------------------------------------------------------|
| ** **             | ** **                        | ** **                                                         |
| **By**                 | **/s/**David B. Berger            |                                                               | **By** | **/s/**Jane C. Moores, Ph.D. |
|                   | (Signature)                       |                                                               | ** ** | (Signature) |
|                   |                              |                                                               |   | ** ** |
| **Name**               | David B. Berger                   |                                                               | **Name** | Jane C. Moores, Ph.D. |
| ** **             |                              |                                                               | ** ** |   |
| **Title**              | **VP & General Counsel** |                                                               | **Title** | **Assistant Vice Chancellor** |
| ** **             | ** **                        |                                                               | ** ** | ** ** |
| **Date**               | 11/20/09                          |                                                               | **Date** | 11/18/09 |

 

Attachment:       Revised Exhibit B

 

----

*****Confidential Treatment Requested**

 

----

 

[...***...]

 

----

*****Confidential TreatmentRequested**

 

----

 

[...***...]

 

----

*****Confidential TreatmentRequested**

 

----

 

[...***...]

 

----

*****Confidential TreatmentRequested**

 

----