Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

Page 1 of 10 **UNITED STA**

**TES ENVIRONMENTA L PROTECTION A**  **GENCY WA** **SHINGTON, D.C. 20460 OFFICE OF CHEMICAL SAFETY**  **AND POLLUTION PREVENTION**

**MEMO RANDUM**  **Date :**  **Aug 27, 2013 SUBJECT:**  **Mandipropamid** : Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk A ssessment for the Section 3 Registration Action on Fresh Basil , Dried Basil, Ginseng , Fruiting Vegetable ( Crop Group 8 - 10 ) ; Small Fruit, V ine C limbing ( Crop S ubgroup 13 - 07F ) , e xcept F uzzy K iwifruit ; Snap Bean, Bulb Onion ( Crop S ubgroup 3 - 07A ), and Green Onion ( Crop S ubgroup 3 - 07B ) . PC Code: 036602 DP Number : 412238 Decision No.: 472747 Registration No. : 100 - 1254 Petition No.: 2E8126 Regulatory Action: Section 3 Risk Assessment Ty

pe: Dietary Case No.: 7058 T XR No.: None CAS No.: 3 7 4726 - 62 - 2 MRID No.: None 40 CFR: **§** 180. 637 FROM: D ennis McNeilly , Chemist

Registration Action Branch 2 Health Effects Divisio n (7509P) THROUGH: Sheila Piper , Chemist

Jennifer Tyler , Chemist Michael Doherty , Ph.D., Senior Scientist Registration Action Branch 2 Health Effects Division (7509P) TO: Laura Nollen/Barbara Madden, RM 05

Risk Integration, Minor Use, Emergency Response Branch Registration Division (7505P) **Executive Summary** A chronic dietary

[food and drinking water] exposure and risk assessment w as conducted using the Dietary

Exposure Evaluation Model software with the Food Commodity Intake DatabaseMandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

Page 2 of 10 (DEEM - FCID) Version 3.16 . This software uses 2003 - 2008 food consumption data from the U.S. Department of Agriculture’s National Health and Nutrition Examination Survey , What We Eat in America, (NHANES/WWEIA). The anal ys is was performed to evaluate a S ection 3 request for the establishment of tolerance s for residues of mandipropamid in/on f resh b asil , dried basil, g inseng , fruiting v egetable ( crop group 8 - 10 ); small f ruit, v ine c limbing ( crop s ubgroup 13 - 07F ) , e xcept f

u zzy k iwifruit ; snap b ean , bulb o nion ( crop s ubgroup 3 - 07A ), and green o nion ( crop s ubgroup 3 - 07B ) . This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1. No acute dietary

toxicity endpoint could be identified based on the toxicology data currently available for mandipropamid ; therefore, n o acute dietary exposure asses sment for mandipropamid was conducted . The Cancer Assessment Review Committee (CARC) classified mandipro pamid as “Not likely to be a human c arcinogen ; ” theref ore a cancer assessment was not performed. Chronic Dietary (Food + Drinking W ater) Exposure Results and Characterization A c hronic dietary exposure assessment w as performed for mandipropamid. The assumptions underlying this unrefined assessment were 100 % crop treated (CT), HED - recommended tolerance levels or tolerance level residues (with the exception of vegetable, tuberous and corm, crop subgroup 1C (which includes the SYN 500003 metabolite ) ), and default DEEM - FCID  (ver. 7.81) processing factors (with the exception of chemical - specific empirical processing factor s (PF) described in Table 1 ). The mean (i.e., relevant to chronic exposure) drinking water e stimate of 79 ppb was provided by the Environmental Fate and Effects Division ( EFED ) and directly in corporated into the chroni c assessment. The e stimated drinking water concentration (EDWC) of 79 μg/L reflects ground water exposure, and was used for chronic exposure. For the general U.S. population, the exposure from food and drinking water utilize s 2 7 % of the chronic population adjusted dose ( cPAD ) . The chronic dietary risk estimate for the most highly exposed population subgroup, children 1 - 2 years old, is 4 6 % of the cPAD. The chronic dietary risk assessment shows that for all included commodities, the chronic dietary risk estimates are below the Agency ’s level of concern (i.e. <100% cPAD). **I. Introduction**  Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population - adjusted dose (PAD). The PAD is equivalent to the point of departure ( e.g., NOAEL, LOAEL) divided by the required uncertainty

or safety factors. For acute and non - cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides website: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: http://www.epa.g ov/fedrgstr/EPA - PEST/2000/July /Day- 12/6061.pdf

; or see SOP 99.6 (8/20/1999).Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

Page 3 of 10 The most recent dietary

risk assessment for mandipropamid was conducted (D 376967 , R . Chesser, 27 - APR - 20 10 ) for a Section 18 Emergency Exemption request for use on fresh and drie d basil. **II. Residue Information**  Tolerances: Permanent tolerances for residues of mandipropamid are listed in 40 CFR §180.637 and are expressed in terms of mandipropamid [4 - chloro - N - [2 - [3 - methoxy- 4 - (2 - propy nyloxy )phenyl]ethyl] - α - (2 - propy nyloxy ) - benzene acetamide ] in/on a variety of raw agricultural commodities ( RACs ) , ranging from 0.01 ppm to 50 ppm. Residue Data used for the Chronic Dietary Assessment: Residues of Concern (residues included in dietary exposure analysis): Tolerances are for the parent only , but for exposure/risk assessment purposes the metabolite SYN 500003 has been included for the vegetable, tuberous and corm, subgroup 1C (Residue chemistry memoranda D333121 & D 328534; D. McNeilly ; 28 - Aug - 2007) . For drinking water, the parent plus the metabolites SYN 500003 and SYN 504851 are included in the exposure/risk assessment. Current Tolerances: The chronic dietary risk assessment was based on the assumption of tolerance - level residues for all commodities with existing tolerances except for vegetable, tuberous and corm, subgroup 1C , which was assessed at 0.026 ppm (DP Num 333121 & 328534; D. McNeilly ; 28 - Aug - 2007) , which includes the metabolites discussed for subgroup 1C . Recommended Tolerance : The chronic dietary risk assessment was ba sed on the assumption of the following HED - recommended tolerance - level residues for the proposed new uses ( D409363 , W. Drew, Aug 27, 2013 ).

Commodity HED - Recommended Tolerance (ppm) Basil, fresh 30 Basil, dried 200 Ginseng 0.3 0 Bean, Snap 0.90 Vegetable, fruiting, group 8 - 10 1.0 Fruit, small, vine climbing, subgroup 13 - 07F, except fuzzy kiwifruit (Note: Grape, raisin rem ains at 3.0 ppm,) 2.0

Onion, bulb, subgroup 3 - 07A 0.1 0 Onion, green, subgroup 3 - 07B 7.0 Percent Crop Treated : 100 % crop treated was assumed for all commodities.Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

Page 4 of 10 Processing Factors: The chemical - specific empirical processing factors in Table 1 have been used in this assessment. Otherwise DEEM - FCID  (ver. 7.81) default processing factors are assumed. **Table 1. Mandipropam id Processing Factors.** 

**Com mo**  **dity Processing Factors (ppm** **)** Grape Raisin Not used, raisin tolerance value was used Wine /Sherry **1.5 (em**  **pirical value) III.**  **Percent Crop Treated Information** The chronic assessments are based on 100% crop treated assumptions for all commodities. **IV. Drinking Water Data**  Drinking Water Exposure Assessment for Proposed Section 3 New Uses on: Basil, Ginseng and Succulent Beans; and Expanded Uses on Bulb Vegetables, Cucurbits, Grapes, and Fruiting Vegetables including Tomatoes., D409108, R. Shamblen, 7/9/2013 . EFED conducted a Tier 1 drinking water exposure assessment for the fung icide mandipropamid. PRZM - GW was used to estimate mandipropamid exposure in ground water. Maximum estimated drinking water concentrations (EDWC s ) in ground water are 87 and 79 μg/L for acute and chronic exposures, respectively . These values are as much as 480 times higher than SCI - GROW model results. Maximum acute and chronic EDWCs in surface waters are 79 and 9.0 μg/L , respectively . Previous exposure assessments evaluated maximum single application rates of 0.13 lbs a.i./A, four times per season. The re gistrant seeks to increase the total annual application rate to 2.08 lbs a.i. /A for tomato and basil by allowing for up to four crop production seasons per year. This proposed multi - season total annual application rate exceeds those assessed in previous drinking water exposure assessments. **Table 2**  **. Tier 1 Estimated**  **Drinking Water Concentrations (EDWC)**  **for Maximum**  **Mandipropamid Use**  **Pattern s**  **. Drinking Water Source**  **(Model , Version**  **) PCA**  **(%) Crop**  **Use Pattern**  **(Maximum Annual Rate) Acute**  **(μg/L) Chronic** 

**(μg/L)** Surface W ater (FIRST , 1.1.1 ) 91 Tomato & Basil (2.08 lbs a.i./A) 79 9.0 Ground W ater (PRZM - GW , 1.01 ) N/A Tomato & Basil ( 2.08 lbs a.i./A ) 87 **79** Ground W ater (SCI - GROW , 2.3 ) N/A Tomato & Basil (2.08 lbs a.i./A) 0.18 **Abbreviation s:**  A= acre; a.i. = active ingredient; μg = micrograms; lbs = pounds (US); N/A = not applicable The Total Residue (TR) modeling approach (USEPA, 2013) was used to estimate aerobic aquatic half - lives, and estimate drinking water concentrations in surface waters. Previous drinking waterMandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

Page 5 of 10 assessments calculated separate half - lives for the parent compound and two degradates of concern , for which exposure was estimated with separate model runs . Simple addition of the exposure estimates for mandipropamid and it’s degradates of concern was used to generate estimated drinking water concentrations. Previous authors acknowledge this approach is conservative because the exposure estimates may not be temporally

coincident. The TR method, however, tallies the parent compo und and it’s degradates of concern prior to calculating a Total Residue half

- life using PestDF . The PRZM - GW chronic ground water value was higher than the surface water value. As a result, the ground water value was incorporated directly into these dietary

assessments under the DEEM - FCID food categories “water, all sources” and “water, indirect, all sources.” The FIRST model and its description are available at the EPA internet site: http://www.epa. gov/oppefed1/models/water/ . **V. DEEM**  **- FCIDTM Program and Consumption Information**  The mandipropamid chronic dietary exposure assessment w as conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM - FCID, V ersion 3.16, which incorporates 2003 - 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly

by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. Based on analy sis of the 2003 - 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most approp riate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, adults 20 - 49, females 13 - 49, and adults 50 - 99 ye ars old. For a chronic dietary

exp osure assessment, an estimate of the residue level in each food or food form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily

consumption estimate for that food/food form to produce a residue intake estim ate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg b ody weight/day

and as a percent of the cPAD. This procedure is performed for each population subgroup. **V I**  **. Toxicological Information**  HED evaluated the toxicology data base of mandipropamid and selected a dose and endpoint for chronic dietary

risk assess ment based on evidence of liver toxicity . N o acute dietary exposure assessment for mandipropamid has been conducted because no appropriate endpoint attributable to a single dose was identified. There were no treatment - related tumors observed in carcinoge nicity

studies in rats and mice and m andipropamid is classified as “Not likely to be a human carcinogen .” Therefore, cancer risk is not a concern for this chemical. Doses andMandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

Page 6 of 10 toxicological endpoints selected for the chronic dietary exposure scenario are summarized in Table 3 . **Table 3**  **. Sum ma**  **ry of Toxicological Doses and Endpoints for Use in Dietary Hum an Health Risk**  **Assessments for Mandipropam**  **id** Exposure Scenario Dose Used in Risk

Assessment, UF POD FQPA SF and Level of

Concern for Risk Assessment Stu dy and Toxicological Effects Acute Dietary ( All populations, including infants and children) None None Not selected. No appropriate dose and endpoint could be identified for any population group. Chronic Dietary (All populations) NOAEL= 5

mg/kg/day UF A= 10x UF H = 10x Chronic RfD = 0.0 5 mg/kg/day FQPA SF =1

cPAD = chronic RfD

FQPA SF = 0.0 5 mg/kg/day **Chronic toxicity –**  **dogs** LOAEL = 40 mg/kg/day, based on evidence of liver toxicity (increased incidence and severity of microscopic pigment in the liver and increased alkaline phosphatase activity in both sexes as well as increased alanine aminotransferase activity in males). Cancer (oral, dermal, inhalation) There w ere no treatment - related tumors observed in carcinogenicity studies in rats and

mice . Classified as “Not likely to be a human carcinogen .” Point of Departure (POD) = A data point or an estimated point that is derived from observed dose - response data and used to mark the beginning of extrapolation to determine risk associated wi th lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in s ensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. **VI I**  **. Results/Discussion**  As stated above, for chronic assessments, HED is co ncerned when dietary risk exceeds 100% of the PAD. The DEEM - FCIDTM analy s i s estimate s the dietary exposure of the general U.S. population and various population subgroups. Table 4 lists the results of the chronic dietary exposure analy ses for the general U.S. p opulation, all infants (<1 year old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, females 13 - 49, adults 20 - 49, and adults 50 - 99 ye ars old . Results of Chronic Dietary Exposure Analy sis Inthe chronic dietary

exposure analy sis, the most highly exposed population subgroup is c hildren 1 - 2 years old which utilizes 4 7 % of the cPAD (Table 4) . The general U.S. population utilizes 2 7 % of the cPAD.Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

Page 7 of 10 **Table 4. Summary of Dietary Exposure and Risk for Mandipropamid**  **(Food and Drinking Water)**  Popul ation Subgroup Acute Dietary Chronic Dietary Cancer Dietary Exposure (mg/kg/day) % aPAD Dietary Exposure (mg/kg/day) % cPAD Dietary Exposure (mg/kg/day) Risk General U.S. Population N/A N/A 0.013 47 5 27 N/A N/A All Infants (< 1 year old) 0.01 1653 2 3 **Children 1 -**  **2 years old 0.02**  **2893 4**  **6** Children 3 - 5 years old 0.020 342 41 Children 6 - 12 years old 0.012 364 25 Youth 13 - 19 years old 0.009 61 7 19 Adults 20 - 49 years old 0.013 459 27 Adults 50 - 99 years old 0.013 425 27 Females 13 - 49 years old 0.013 293 27 N/A = Not applicable. **VII I**  **. Characterization of Inputs/Outputs**  This analy sis is a highly

conservative dietary

exposure assessment. An unrefined chronic dietary exposure analy sis was performed for chronic exposure to mandipropamid using DEEM - FCIDTM . Tolerance - level residues for all commodities, except vegetable, tuberous and corm, subgroup 1C, DEEM (ver. 7.81) default processing factors (except grape, wine and sherry , 1.5X) and 100% crop treated were assumed for this assessment. Further refinement to the analy ses could be made through the use of anticipated residues, incorporation of percent crop treated information with mandipropamid, and/or monitoring data that better reflect residues at the time of consumption. Since risk estimates ar e below HED’s level of concern, a more highly refined analy sis is not needed at this time. **IX. Conclusions**  Based on the conservative assumptions noted above , chronic dietary risk estimates for mandipropamid do not exceed HED’s level of concern for the ge neral U . S . population, or any of the population subgroups, including those comprised of infants and children. X. **List of Attachments** : Attachment 1: Residue Input File for Chronic Analy sis Attachment 2: Results of Chronic Dietary Exposure Analy sisMandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

Page 8 of 10 Attachment 1: Residue Input File for Chronic (Non - Cancer) Analy s i s US EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for MANDIPROPAMID Residue file: J: \ Mandy \ deem \ 036602C.R08 Adjust. #2 NOT used Analysis Date 07 - 25 - 2013 Residue file dated: 07 - 25 - 2013/13:59:50 Reference dose (RfD) = 0.05 mg/kg bw/day

---------------------------------------------------------------------------------- Food Crop Residue Adj.Factors EPA Code Grp Food Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ 0401005000 4A Amaranth, leafy 20.000 000 1.000 1.000 0103015000 1CD Arrowroot, flour 0.026000 1.000 1.000 0103015001 1CD Arrowroot, flour - babyfood 0.026000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.026000 1.00 0 1.000 0401018000 4A Arugula 20.000000 1.000 1.000 0902021000 9B Balsam pear 0.600000 1.000 1.000 1901028000 19A Basil, fresh leaves 30.000000 1.000 1.0 00 1901028001 19A Basil, fresh leaves - babyfood 30.000000 1.000 1.000 1901029000 19A Basil, dried leaves 200.000000 1.000 1.000 1901029001 19A Basil, dried leaves - babyfood 200.000000 1.000 1.000 0601 043000 6A Bean, snap, succulent 0.900000 1.000 1.000 0601043001 6A Bean, snap, succulent - babyfood 0.900000 1.000 1.000 0501061000 5A Broccoli 3.000000 1.000 1.000 0501061001 5A Broccoli - babyfood 3.000000 1.000 1.000 0501062000 5A Broccoli, Chinese 3.000000 1.000 1.000 0502063000 5B Broccoli raab 25.000000 1.000 1.000 0501064000 5A Brussels sprouts 3.000000 1.000 1.000 0501069000 5A Cabbage 3.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 25.000000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 3.000000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 3.000000 1.000 1.000 0901075000 9A Cantaloupe 0.600000 1.000 1.000 0402076000 4B Cardoon 20.000000 1.000 1.000 0103082000 1CD Cassava 0.026000 1.000 1.000 0103082001 1CD Cassava - babyfood 0.026000 1.000 1.000 0501083000 5A Cauliflower 3.0 00000 1.000 1.000 0402085000 4B Celery 20.000000 1.000 1.000 0402085001 4B Celery - babyfood 20.000000 1.000 1.000 0402086000 4B Celery, juice 20.000000 1. 000 1.000 0402087000 4B Celtuce 20.000000 1.000 1.000 0902088000 9B Chayote, fruit 0.600000 1.000 1.000 0902102000 9B Chinese waxgourd 0.600000 1.000 1 .000 0302103000 3B Chive, fresh leaves 7.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 20.000000 1.000 1.000 0502117000 5B Collards 25.000000 1.000 1.000 04 01133000 4A Cress, garden 20.000000 1.000 1.000 0401134000 4A Cress, upland 20.000000 1.000 1.000 0902135000 9B Cucumber 0.600000 1.000 1.000 0401138000 4 A Dandelion, leaves 20.000000 1.000 1.000 0103139000 1CD Dasheen, corm 0.026000 1.000 1.000 0802148000 8BC Eggplant 1.000000 1.000 1.000 0401150000 4A Endive 20.000000 1.000 1.000 0402152000 4B Fennel, Florence 20.000000 1.000 1.000 0301165000 3A Garlic, bulb 0.100000 1.000 1.000 0301165001 3A Garlic, bulb - bab yfood 0.100000 1.000 1.000 0103166000 1CD Ginger 0.026000 1.000 1.000 0103166001 1CD Ginger - babyfood 0.026000 1.000 1.000 0103167000 1CD Ginger, dried 0.026000 1.000 1.000 0101168000 1AB Ginseng, dried 0.300000 1.000 1.000 1302174000 13B Gooseberry 2.000000 1.000 1.000 1304175000 13D Grape 2 .000000 1.000 1.000 1304176000 13D Grape, juice 2.000000 1.200 1.000 1304176001 13D Grape, juice - babyfood 2.000000 1.200 1.000 9500177000 O Grape, leaves 2.000000 1.000 1.000 9500178000 O Grape, raisin 3.000000 1.000 1.000Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

Page 9 of 10 1304179000 13D Grape, wine and sherry 2.000000 1.500 1.000 0901187000 9A Honeydew melon 0.600000 1.000 1.000 9500188000 O Hop 50.000000 1.000 1.000 0502194000 5B Kale 25.000000 1.000 1.000 0501196000 5A Kohlrabi 3.000000 1.000 1.000 0302198000 3B Leek 7.000000 1.000 1.000 0401204000 4A Lettuce, head 20.000000 1.000 1.000 0401205000 4A Lettuce, leaf 20.000000 1.000 1.000 0502229000 5B Mustard greens 25.000000 1.000 1.000 0802234000 8BC Okra 1.000000 1.000 1.000 0301237000 3A Onion, bulb 0.100000 1.000 1.000 0301237001 3A Onio n, bulb - babyfood 0.100000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.100000 9.000 1.000 0301238001 3A Onion, bulb, dried - babyfood 0.100000 9.000 1.000 0302239000 3B Onion, green 7.000000 1.000 1.000 0401248000 4A Parsley, leaves 20.000000 1.000 1.000 0802270000 8B Pepper, bell 1.000000 1.000 1.000 0802270001 8B Pepper, bell - babyfood 1.000000 1.000 1.000 0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 0802271001 8B Pepper, bell, dried - babyfood 1.000000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 1.000000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 0103296000 1C Potato, chips 0.026000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.026000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes) - b 0.026000 6.500 1.000 0103298000 1C Potato, flour 0.026000 6.500 1.000 0103298001 1C Potato, flour - babyfood 0.026000 6.500 1.000 0103299000 1C Potato, tuber, w/peel 0.026000 1.000 1.000 0103299001 1C Potato, tuber, w/peel - babyfood 0.026000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.026000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel - babyfood 0.026000 1.000 1.000 0902308000 9B Pumpkin 0.600000 1.000 1.000 09023090 00 9B Pumpkin, seed 0.600000 1.000 1.000 0401313000 4A Radicchio 20.000000 1.000 1.000 0502318000 5B Rape greens 25.000000 1.000 1.000 0402322000 4B Rh ubarb 20.000000 1.000 1.000 0302338500 3B Shallot, fresh leaves 7.000000 1.000 1.000 0401355000 4A Spinach 20.000000 1.000 1.000 0401355001 4A Spinach - baby food 20.000000 1.000 1.000 0902356000 9B Squash, summer 0.600000 1.000 1.000 0902356001 9B Squash, summer - babyfood 0.600000 1.000 1.000 0902357000 9B Squash, winter 0.600000 1.000 1.000 0902357001 9B Squash, winter - babyfood 0.600000 1.000 1.000 0103366000 1CD Sweet potato 0.026000 1.000 1.000 0103366001 1CD Sweet potato - babyfood 0.026000 1.000 1.000 0402367000 4B Swiss chard 20.000000 1.000 1.000 0103371000 1CD Tanier, corm 0.026000 1.000 1.000 0801374000 8A Tomatillo 1.00000 0 1.000 1.000 0801375000 8A Tomato 1.000000 1.000 1.000 0801375001 8A Tomato - babyfood 1.000000 1.000 1.000 0801376000 8A Tomato, paste 1.000000 5.400 1.000 0801376001 8A Tomato, paste - babyfood 1.000000 5.400 1.000 0801377000 8A Tomato, puree 1.000000 3.300 1.000 0801377001 8A Tomato, puree - babyfood 1.000000 3.300 1.000 0801378000 8A Tomato, dried 1.000000 14.300 1.000 0801378001 8A Tomato, dried - babyfood 1.000000 14.300 1.000 0801379000 8A Tomato, juice 1.000000 1.500 1.000 080138 0000 8A Tomato, Tree 1.000000 1.000 1.000 0103387000 1CD Turmeric 0.026000 1.000 1.000 0502389000 5B Turnip, greens 25.000000 1.000 1.000 8601000000 86A Water, direct, all sources 0.079000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.079000 1.000 1.000 0901399000 9A Watermelon 0.600000 1.000 1.000 0901400000 9A Watermelon , juice 0.600000 1.000 1.000 0103406000 1CD Yam, true 0.026000 1.000 1.000 0103407000 1CD Yam bean 0.026000 1.000 1.000 0301338000 3A Shallot, bulb 0.100000 1.000 1.000Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

Page 10 of 10 Attachment 2 : Res ults of Chronic Dietary Exposure Analy sis US EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for MANDIPROPAMID NHANE S 2003 - 2008 2 - day Residue file name: J: \ Mandy \ deem \ 036602C.R08 Adjustment factor #2 NOT used. Analysis Date 07 - 25 - 2013/14:00:17 Residue file dated: 07 - 25 - 2013/13:59:50 Reference dose (RfD, Chronic) = .05 mg/kg bw/day

=============================== ================================================ Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------- ------------ ------------- ---------------- Total US Population 0.013475 27.0% Hispanic 0.011932 23.9% Non - Hisp - White 0.013909 27.8% Non - Hisp - Black 0.012226 24.5% Non - Hisp - Other 0.014678 29.4% Nursing Infants 0.005723 11.4% Non - Nursing Infa nts 0.014302 28.6% Female 13+ PREG 0.011797 23.6% Children 1 - 6 0.020727 41.5% Children 7 - 12 0.0115 23 23.0% Male 13 - 19 0.009229 18.5% Female 13 - 19/NP 0.010005 20.0% Male 20+ 0.012668 25.3% Female 20+ /NP 0.014206 28.4% Seniors 55+ 0.013238 26.5% All Infants 0.011653 23.3% Female 13 - 50 0.013273 26.5% Children 1 - 2 0.022893 45.8% Children 3 - 5 0.020342 40.7% Children 6 - 12 0.012364 24.7% Yout h 13 - 19 0.009617 19.2% Adults 20 - 49 0.013459 26.9% Adults 50 - 99 0.013425 26.9% Female 13 - 49 0.013293 26.6%

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