Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY

 AND POLLUTION PREVENTION

MEMORANDUM

Date: Aug 27, 2013

SUBJECT: Mandipropamid: Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessment for the Section 3 Registration Action on Fresh 

Basil, Dried Basil, Ginseng, Fruiting Vegetable (Crop Group 8-10); Small Fruit, 

Vine Climbing (Crop Subgroup 13-07F), except Fuzzy Kiwifruit; Snap Bean, Bulb 

Onion (Crop Subgroup 3-07A), and Green Onion (Crop Subgroup 3-07B).

PC Code: 036602 DP Number: 412238 

Decision No.: 472747 Registration No.: 100-1254

Petition No.: 2E8126 Regulatory Action: Section 3

Risk Assessment Type: Dietary Case No.: 7058

TXR No.: None CAS No.: 374726-62-2

MRID No.: None 40 CFR: §180.637

FROM: Dennis McNeilly, Chemist

Registration Action Branch 2

Health Effects Division (7509P)

THROUGH: Sheila Piper, Chemist

Jennifer Tyler, Chemist

Michael Doherty, Ph.D., Senior Scientist

Registration Action Branch 2

Health Effects Division (7509P)

TO: Laura Nollen/Barbara Madden, RM 05

Risk Integration, Minor Use, Emergency Response Branch

Registration Division (7505P)

Executive Summary

A chronic dietary [food and drinking water] exposure and risk assessment was conducted using 

the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database 
Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

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(DEEM-FCID) Version 3.16. This software uses 2003-2008 food consumption data from the 

U.S. Department of Agriculture’s National Health and Nutrition Examination Survey, What We 

Eat in America, (NHANES/WWEIA). The analysis was performed to evaluate a Section 3 

request for the establishment of tolerances for residues of mandipropamid in/on fresh basil, dried 

basil, ginseng, fruiting vegetable (crop group 8-10); small fruit, vine climbing (crop subgroup 13-

07F), except fuzzy kiwifruit; snap bean, bulb onion (crop subgroup 3-07A), and green onion

(crop subgroup 3-07B). This memorandum was reviewed by two peer reviewers of the DESAC, 

per DESAC SOP 2012.1.

No acute dietary toxicity endpoint could be identified based on the toxicology data currently

available for mandipropamid; therefore, no acute dietary exposure assessment for 

mandipropamid was conducted. The Cancer Assessment Review Committee (CARC) classified 

mandipropamid as “Not likely to be a human carcinogen;” therefore a cancer assessment was not 

performed.

Chronic Dietary (Food + Drinking Water) Exposure Results and Characterization

A chronic dietary exposure assessment was performed for mandipropamid. The assumptions 

underlying this unrefined assessment were 100% crop treated (CT), HED-recommended 

tolerance levels or tolerance level residues (with the exception of vegetable, tuberous and corm, 

crop subgroup 1C (which includes the SYN 500003 metabolite)), and default DEEM-FCID

(ver. 7.81) processing factors (with the exception of chemical-specific empirical processing 

factors (PF) described in Table 1). The mean (i.e., relevant to chronic exposure) drinking water 

estimate of 79 ppb was provided by the Environmental Fate and Effects Division (EFED) and 

directly incorporated into the chronic assessment. The estimated drinking water concentration 

(EDWC) of 79 μg/L reflects ground water exposure, and was used for chronic exposure.

For the general U.S. population, the exposure from food and drinking water utilizes 27% of the 

chronic population adjusted dose (cPAD). The chronic dietary risk estimate for the most highly

exposed population subgroup, children 1-2 years old, is 46% of the cPAD. The chronic dietary

risk assessment shows that for all included commodities, the chronic dietary risk estimates are 

below the Agency’s level of concern (i.e. <100% cPAD).

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (e.g., NOAEL, LOAEL) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides website: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 

(8/20/1999).
Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

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The most recent dietary risk assessment for mandipropamid was conducted (D376967, R.

Chesser, 27-APR-2010) for a Section 18 Emergency Exemption request for use on fresh and 

dried basil.

II. Residue Information

Tolerances: Permanent tolerances for residues of mandipropamid are listed in 40 CFR §180.637 

and are expressed in terms of mandipropamid [4-chloro-N-[2-[3-methoxy-4-(2-

propynyloxy)phenyl]ethyl]- α-(2-propynyloxy)-benzeneacetamide] in/on a variety of raw 

agricultural commodities (RACs), ranging from 0.01 ppm to 50 ppm.

Residue Data used for the Chronic Dietary Assessment:

Residues of Concern (residues included in dietary exposure analysis): Tolerances are for the 

parent only, but for exposure/risk assessment purposes the metabolite SYN 500003 has been 

included for the vegetable, tuberous and corm, subgroup 1C (Residue chemistry memoranda 

D333121 & D328534; D. McNeilly; 28-Aug-2007). For drinking water, the parent plus the 

metabolites SYN 500003 and SYN 504851 are included in the exposure/risk assessment. 

Current Tolerances: The chronic dietary risk assessment was based on the assumption of 

tolerance-level residues for all commodities with existing tolerances except for vegetable, 

tuberous and corm, subgroup 1C, which was assessed at 0.026 ppm (DP Num 333121 & 328534; 

D. McNeilly; 28-Aug-2007), which includes the metabolites discussed for subgroup 1C.

Recommended Tolerance: The chronic dietary risk assessment was based on the assumption of 

the following HED-recommended tolerance-level residues for the proposed new uses (D409363, 

W. Drew, Aug 27, 2013).

Commodity HED-Recommended

 Tolerance (ppm) 

Basil, fresh 30

Basil, dried 200

Ginseng 0.30

Bean, Snap 0.90

Vegetable, fruiting, group 8-10 1.0

Fruit, small, vine climbing,

subgroup 13-07F, except fuzzy

kiwifruit

(Note: Grape, raisin remains at 3.0 

ppm,)

2.0

Onion, bulb, subgroup 3-07A 0.10

Onion, green, subgroup 3-07B 7.0

Percent Crop Treated: 100 % crop treated was assumed for all commodities.
Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

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Processing Factors: The chemical-specific empirical processing factors in Table 1 have been 

used in this assessment. Otherwise DEEM-FCID (ver. 7.81) default processing factors are 

assumed.

Table 1. Mandipropamid Processing Factors.

Commodity Processing Factors (ppm)

Grape

 Raisin Not used, raisin tolerance value was used

 Wine/Sherry 1.5 (empirical value)

III. Percent Crop Treated Information

The chronic assessments are based on 100% crop treated assumptions for all commodities.

IV. Drinking Water Data

Drinking Water Exposure Assessment for Proposed Section 3 New Uses on: Basil, Ginseng and Succulent Beans; 

and Expanded Uses on Bulb Vegetables, Cucurbits, Grapes, and Fruiting Vegetables including Tomatoes., D409108, 

R. Shamblen, 7/9/2013.

EFED conducted a Tier 1 drinking water exposure assessment for the fungicide mandipropamid. 

PRZM-GW was used to estimate mandipropamid exposure in ground water. Maximum estimated 

drinking water concentrations (EDWCs) in ground water are 87 and 79 μg/L for acute and 

chronic exposures, respectively. These values are as much as 480 times higher than SCI-GROW 

model results. Maximum acute and chronic EDWCs in surface waters are 79 and 9.0 μg/L,

respectively.

Previous exposure assessments evaluated maximum single application rates of 0.13 lbs a.i./A, 

four times per season. The registrant seeks to increase the total annual application rate to 2.08 

lbs a.i./A for tomato and basil by allowing for up to four crop production seasons per year. This 

proposed multi-season total annual application rate exceeds those assessed in previous drinking 

water exposure assessments. 

Table 2. Tier 1 Estimated Drinking Water Concentrations (EDWC) for Maximum Mandipropamid 

Use Patterns.

Drinking Water Source

(Model, Version)

PCA

(%)

Crop Use Pattern

(Maximum Annual Rate)

Acute

(μg/L)

Chronic

(μg/L)

Surface Water (FIRST, 1.1.1) 91 Tomato & Basil

(2.08 lbs a.i./A) 79 9.0

Ground Water (PRZM-GW, 1.01) N/A Tomato & Basil

(2.08 lbs a.i./A)

87 79

Ground Water (SCI-GROW, 2.3) N/A Tomato & Basil 

(2.08 lbs a.i./A) 0.18

Abbreviations: A= acre; a.i. = active ingredient; μg = micrograms; lbs = pounds (US); N/A = not applicable

The Total Residue (TR) modeling approach (USEPA, 2013) was used to estimate aerobic aquatic 

half-lives, and estimate drinking water concentrations in surface waters. Previous drinking water 
Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

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assessments calculated separate half-lives for the parent compound and two degradates of 

concern, for which exposure was estimated with separate model runs. Simple addition of the 

exposure estimates for mandipropamid and it’s degradates of concern was used to generate 

estimated drinking water concentrations. Previous authors acknowledge this approach is 

conservative because the exposure estimates may not be temporally coincident. The TR method, 

however, tallies the parent compound and it’s degradates of concern prior to calculating a Total 

Residue half-life using PestDF.

The PRZM-GW chronic ground water value was higher than the surface water value. As a result, 

the ground water value was incorporated directly into these dietary assessments under the 

DEEM-FCID food categories “water, all sources” and “water, indirect, all sources.” The FIRST 

model and its description are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 

V. DEEM-FCIDTM Program and Consumption Information

The mandipropamid chronic dietary exposure assessment was conducted using the Dietary

Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID, 

Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. Based on analysis 

of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and 

survey respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total average 

estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the 

cPAD. This procedure is performed for each population subgroup.

VI. Toxicological Information

HED evaluated the toxicology data base of mandipropamid and selected a dose and endpoint for 

chronic dietary risk assessment based on evidence of liver toxicity. No acute dietary exposure 

assessment for mandipropamid has been conducted because no appropriate endpoint attributable 

to a single dose was identified. There were no treatment-related tumors observed in 

carcinogenicity studies in rats and mice and mandipropamid is classified as “Not likely to be a 

human carcinogen.” Therefore, cancer risk is not a concern for this chemical. Doses and 
Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

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toxicological endpoints selected for the chronic dietary exposure scenario are summarized in 

Table 3.

Table 3. Summary of Toxicological Doses and Endpoints for Use in Dietary Human Health Risk 

Assessments for Mandipropamid

Exposure

Scenario

Dose Used in Risk 

Assessment, UF 

POD

FQPA SF and Level of 

Concern for Risk 

Assessment

Study and Toxicological Effects

Acute Dietary (All 

populations, 

including infants and 

children)

None None Not selected.

No appropriate dose and endpoint could 

be identified for any population group.

Chronic Dietary

(All populations)

NOAEL= 5

mg/kg/day

UFA= 10x

UFH= 10x

Chronic RfD = 0.05

mg/kg/day

FQPA SF =1

cPAD = chronic RfD

 FQPA SF

= 0.05 mg/kg/day

Chronic toxicity – dogs

LOAEL = 40 mg/kg/day, based on 

evidence of liver toxicity (increased 

incidence and severity of microscopic 

pigment in the liver and increased 

alkaline phosphatase activity in both 

sexes as well as increased alanine 

aminotransferase activity in males).

Cancer (oral, dermal, 

inhalation)

There were no treatment-related tumors observed in carcinogenicity studies in rats and 

mice. Classified as “Not likely to be a human carcinogen.”

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in sensitivity 

among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population 

adjusted dose (a = acute, c = chronic). RfD = reference dose. 

VII. Results/Discussion 

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of 

the PAD. The DEEM-FCIDTM analysis estimates the dietary exposure of the general U.S. 

population and various population subgroups. Table 4 lists the results of the chronic dietary

exposure analyses for the general U.S. population, all infants (<1 year old), children 1-2, children 

3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years old. 

Results of Chronic Dietary Exposure Analysis

In the chronic dietary exposure analysis, the most highly exposed population subgroup is children 

1-2 years old which utilizes 47% of the cPAD (Table 4). The general U.S. population utilizes 

27% of the cPAD.
Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

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Table 4. Summary of Dietary Exposure and Risk for Mandipropamid (Food and Drinking 

Water)

Population Subgroup

Acute Dietary Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day) % aPAD

Dietary 

Exposure

(mg/kg/day) % cPAD

Dietary 

Exposure

(mg/kg/day) Risk

General U.S. Population

N/A N/A

0.013475 27

N/A N/A

All Infants (< 1 year old) 0.011653 23

Children 1-2 years old 0.022893 46

Children 3-5 years old 0.020342 41

Children 6-12 years old 0.012364 25

Youth 13-19 years old 0.009617 19

Adults 20-49 years old 0.013459 27

Adults 50-99 years old 0.013425 27

Females 13-49 years old 0.013293 27

N/A = Not applicable.

VIII.Characterization of Inputs/Outputs

This analysis is a highly conservative dietary exposure assessment. An unrefined chronic dietary

exposure analysis was performed for chronic exposure to mandipropamid using DEEM-FCIDTM. 

Tolerance-level residues for all commodities, except vegetable, tuberous and corm, subgroup 1C, 

DEEM (ver. 7.81) default processing factors (except grape, wine and sherry, 1.5X) and 100% 

crop treated were assumed for this assessment. Further refinement to the analyses could be made 

through the use of anticipated residues, incorporation of percent crop treated information with 

mandipropamid, and/or monitoring data that better reflect residues at the time of consumption. 

Since risk estimates are below HED’s level of concern, a more highly refined analysis is not 

needed at this time.

IX. Conclusions

Based on the conservative assumptions noted above, chronic dietary risk estimates for 

mandipropamid do not exceed HED’s level of concern for the general U.S. population, or any of 

the population subgroups, including those comprised of infants and children. 

X. List of Attachments:

Attachment 1: Residue Input File for Chronic Analysis

Attachment 2: Results of Chronic Dietary Exposure Analysis
Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

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Attachment 1: Residue Input File for Chronic (Non-Cancer) Analysis

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for MANDIPROPAMID

Residue file: J:\Mandy\deem\036602C.R08 Adjust. #2 NOT used

Analysis Date 07-25-2013 Residue file dated: 07-25-2013/13:59:50

Reference dose (RfD) = 0.05 mg/kg bw/day

----------------------------------------------------------------------------------

Food Crop Residue Adj.Factors

EPA Code Grp Food Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------

0401005000 4A Amaranth, leafy 20.000000 1.000 1.000 

0103015000 1CD Arrowroot, flour 0.026000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.026000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.026000 1.000 1.000 

0401018000 4A Arugula 20.000000 1.000 1.000 

0902021000 9B Balsam pear 0.600000 1.000 1.000 

1901028000 19A Basil, fresh leaves 30.000000 1.000 1.000 

1901028001 19A Basil, fresh leaves-babyfood 30.000000 1.000 1.000 

1901029000 19A Basil, dried leaves 200.000000 1.000 1.000 

1901029001 19A Basil, dried leaves-babyfood 200.000000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.900000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.900000 1.000 1.000 

0501061000 5A Broccoli 3.000000 1.000 1.000 

0501061001 5A Broccoli-babyfood 3.000000 1.000 1.000 

0501062000 5A Broccoli, Chinese 3.000000 1.000 1.000 

0502063000 5B Broccoli raab 25.000000 1.000 1.000 

0501064000 5A Brussels sprouts 3.000000 1.000 1.000 

0501069000 5A Cabbage 3.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 25.000000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 3.000000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 3.000000 1.000 1.000 

0901075000 9A Cantaloupe 0.600000 1.000 1.000 

0402076000 4B Cardoon 20.000000 1.000 1.000 

0103082000 1CD Cassava 0.026000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.026000 1.000 1.000 

0501083000 5A Cauliflower 3.000000 1.000 1.000 

0402085000 4B Celery 20.000000 1.000 1.000 

0402085001 4B Celery-babyfood 20.000000 1.000 1.000 

0402086000 4B Celery, juice 20.000000 1.000 1.000 

0402087000 4B Celtuce 20.000000 1.000 1.000 

0902088000 9B Chayote, fruit 0.600000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.600000 1.000 1.000 

0302103000 3B Chive, fresh leaves 7.000000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 20.000000 1.000 1.000 

0502117000 5B Collards 25.000000 1.000 1.000 

0401133000 4A Cress, garden 20.000000 1.000 1.000 

0401134000 4A Cress, upland 20.000000 1.000 1.000 

0902135000 9B Cucumber 0.600000 1.000 1.000 

0401138000 4A Dandelion, leaves 20.000000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.026000 1.000 1.000 

0802148000 8BC Eggplant 1.000000 1.000 1.000 

0401150000 4A Endive 20.000000 1.000 1.000 

0402152000 4B Fennel, Florence 20.000000 1.000 1.000 

0301165000 3A Garlic, bulb 0.100000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.100000 1.000 1.000 

0103166000 1CD Ginger 0.026000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.026000 1.000 1.000 

0103167000 1CD Ginger, dried 0.026000 1.000 1.000 

0101168000 1AB Ginseng, dried 0.300000 1.000 1.000 

1302174000 13B Gooseberry 2.000000 1.000 1.000 

1304175000 13D Grape 2.000000 1.000 1.000 

1304176000 13D Grape, juice 2.000000 1.200 1.000 

1304176001 13D Grape, juice-babyfood 2.000000 1.200 1.000 

9500177000 O Grape, leaves 2.000000 1.000 1.000 

9500178000 O Grape, raisin 3.000000 1.000 1.000 
Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

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1304179000 13D Grape, wine and sherry 2.000000 1.500 1.000 

0901187000 9A Honeydew melon 0.600000 1.000 1.000 

9500188000 O Hop 50.000000 1.000 1.000 

0502194000 5B Kale 25.000000 1.000 1.000 

0501196000 5A Kohlrabi 3.000000 1.000 1.000 

0302198000 3B Leek 7.000000 1.000 1.000 

0401204000 4A Lettuce, head 20.000000 1.000 1.000 

0401205000 4A Lettuce, leaf 20.000000 1.000 1.000 

0502229000 5B Mustard greens 25.000000 1.000 1.000 

0802234000 8BC Okra 1.000000 1.000 1.000 

0301237000 3A Onion, bulb 0.100000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.100000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.100000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.100000 9.000 1.000 

0302239000 3B Onion, green 7.000000 1.000 1.000 

0401248000 4A Parsley, leaves 20.000000 1.000 1.000 

0802270000 8B Pepper, bell 1.000000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 1.000000 1.000 1.000 

0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 1.000000 1.000 1.000 

0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 1.000000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 

0103296000 1C Potato, chips 0.026000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.026000 6.500 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.026000 6.500 1.000 

0103298000 1C Potato, flour 0.026000 6.500 1.000 

0103298001 1C Potato, flour-babyfood 0.026000 6.500 1.000 

0103299000 1C Potato, tuber, w/peel 0.026000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.026000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.026000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.026000 1.000 1.000 

0902308000 9B Pumpkin 0.600000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.600000 1.000 1.000 

0401313000 4A Radicchio 20.000000 1.000 1.000 

0502318000 5B Rape greens 25.000000 1.000 1.000 

0402322000 4B Rhubarb 20.000000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 7.000000 1.000 1.000 

0401355000 4A Spinach 20.000000 1.000 1.000 

0401355001 4A Spinach-babyfood 20.000000 1.000 1.000 

0902356000 9B Squash, summer 0.600000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.600000 1.000 1.000 

0902357000 9B Squash, winter 0.600000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.600000 1.000 1.000 

0103366000 1CD Sweet potato 0.026000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.026000 1.000 1.000 

0402367000 4B Swiss chard 20.000000 1.000 1.000 

0103371000 1CD Tanier, corm 0.026000 1.000 1.000 

0801374000 8A Tomatillo 1.000000 1.000 1.000 

0801375000 8A Tomato 1.000000 1.000 1.000 

0801375001 8A Tomato-babyfood 1.000000 1.000 1.000 

0801376000 8A Tomato, paste 1.000000 5.400 1.000 

0801376001 8A Tomato, paste-babyfood 1.000000 5.400 1.000 

0801377000 8A Tomato, puree 1.000000 3.300 1.000 

0801377001 8A Tomato, puree-babyfood 1.000000 3.300 1.000 

0801378000 8A Tomato, dried 1.000000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 1.000000 14.300 1.000 

0801379000 8A Tomato, juice 1.000000 1.500 1.000 

0801380000 8A Tomato, Tree 1.000000 1.000 1.000 

0103387000 1CD Turmeric 0.026000 1.000 1.000 

0502389000 5B Turnip, greens 25.000000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.079000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.079000 1.000 1.000 

0901399000 9A Watermelon 0.600000 1.000 1.000 

0901400000 9A Watermelon, juice 0.600000 1.000 1.000 

0103406000 1CD Yam, true 0.026000 1.000 1.000 

0103407000 1CD Yam bean 0.026000 1.000 1.000 

0301338000 3A Shallot, bulb 0.100000 1.000 1.000 
Mandipropamid Dietary Exposure and Risk Assessment DP Number: 412238

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Attachment 2: Results of Chronic Dietary Exposure Analysis

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for MANDIPROPAMID NHANES 2003-2008 2-day

Residue file name: J:\Mandy\deem\036602C.R08 Adjustment factor #2 NOT used.

Analysis Date 07-25-2013/14:00:17 Residue file dated: 07-25-2013/13:59:50

Reference dose (RfD, Chronic) = .05 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.013475 27.0%

Hispanic 0.011932 23.9%

Non-Hisp-White 0.013909 27.8%

Non-Hisp-Black 0.012226 24.5%

Non-Hisp-Other 0.014678 29.4%

Nursing Infants 0.005723 11.4%

Non-Nursing Infants 0.014302 28.6%

Female 13+ PREG 0.011797 23.6%

Children 1-6 0.020727 41.5%

Children 7-12 0.011523 23.0%

Male 13-19 0.009229 18.5%

Female 13-19/NP 0.010005 20.0%

Male 20+ 0.012668 25.3%

Female 20+/NP 0.014206 28.4%

Seniors 55+ 0.013238 26.5%

All Infants 0.011653 23.3%

Female 13-50 0.013273 26.5%

Children 1-2 0.022893 45.8%

Children 3-5 0.020342 40.7%

Children 6-12 0.012364 24.7%

Youth 13-19 0.009617 19.2%

Adults 20-49 0.013459 26.9%

Adults 50-99 0.013425 26.9%

Female 13-49 0.013293 26.6%

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