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### EO 12866/13563 Review Draft – As Submitted 1 Rin2070-AJ52_EO12866_Ethylene Glycol Ethers-SNUR_FRM_FRdocument_2014-08-15.docx 2 3 BILLING CODE 6560-50-P 4 ENVIRONMENTAL PRO TECTION AGENCY 5 40 CFR Parts 9 and 721 6 EPA-HQ-OPPT-2009-0767; FRL- XXXX-X 7 RIN 2070-AJ52 8 Ethylene Glycol Ethers; Significant New Use Rule 9 AGENCY: Environmental Protection Agency (EPA). 10 ACTION: Final Rule. 11 SUMMARY: Under the Toxic Substances Control Act (TSCA), EPA is promulgating a 12 significant new use rule (SNUR) for seven ethylene glycol ethe rs (also known as 13 glymes). This rule will require persons w ho intend to manufacture (including import) or 14 process any of the seven ethylen e glycol ethers for an activit y that is designated as a 15 significant new use by this rule to notify EP A at least 90 days before commencing such 16 manufacture or processing. The required notifications would provide EPA with the 17 opportunity to evaluate the intended use and, if necessary based on the information 18 available at that time, an opportunity to protect ag ainst potential unreasonable risks, if 19 any, from that activity before it occurs. EPA is also making a technical amendment to the 20 codified list of control numb ers for approved information coll ection activities so that it 21 includes the control number assigned by the Office of Management and Budget (OMB) 22 to the information collection activities contained in this rule. 23 DATES: This final rule is effective [ insert date 60 days after date of publication in the 24 Federal Register ]. 25 ADDRESSES: The docket for this action, identi fied by docket identification (ID) 26*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 2 of 30 number EPA-HQ-OPPT-2009-0767, is available at http://www.regulations.gov or at the 27 Office of Pollution Prevention and Toxics Do cket (OPPT Docket), EPA Docket Center 28 (EPA/DC), West William Jefferson Clint on Bldg., Rm. 3334, 1301 Constitution Ave., 29 NW., Washington, DC. The Public Reading Room is open from 8:30 a.m. to 4:30 p.m., 30 Monday through Friday, excluding legal holidays. The telephone number for the Public 31 Reading Room is (202) 566-1744, and the tele phone number for the OPPT Docket is 32 (202) 566-0280. Please review the visitor instructions and additional information about 33 the docket available at http://www.epa.gov/dockets

. 34 FOR FURTHER INFORMATION CONTACT: For technical information contact : 35 Kirsten Hesla, Chemical Control Division (7405M), Office of Pollution Prevention and 36 Toxics, Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, 37 DC 20460-0001; telephone number: 202-564-2984; e-mail address: 38 hesla.kirsten@epa.gov

. 39 For general information contact : The TSCA-Hotline, ABVI-Goodwill, 422 South 40 Clinton Ave., Rochester, NY 14620; telephon e number: (202) 554–1404; e-mail address: 41 TSCA-Hotline@epa.gov

. 42 SUPPLEMENTARY INFORMATION: 43 I. Executive Summary 44 A. Does this Action Apply to Me? 45 You may be potentially affected by th is action if you manuf acture (including 46 import) or process any of the chemical substances covered by this final rule

. The North 47 American Industrial Classification System ( NAICS) codes identified are not intended to 48 be exhaustive, but rather provides a guide to help readers determine whether this 49 document applies to them. Potentially affected entities may include: 50*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 3 of 30 • Manufacturers of one or more of subject chemical substances (NAICS codes 51 325 and 324110); e.g., chemical manufactur ing and petroleum refineries; 52

• All other basic organic chemical manufacturing (NAICS code 325199); 53

• Printing ink manufacturing (NAICS code 325910); 54

• Paint and coating manufacturi ng (NAICS code 325510); 55

• Adhesive manufacturing (NAICS code 325520); and 56

• Motor vehicle brake system manuf acturing (NAICS code 336340). 57 This action may also affect cert ain entities through pre-existing import 58 certification and export notification rule s under TSCA. Persons who import any 59 chemical substance are subject to the TSCA section 13 (15 U.S.C. 2612) import 60 certification requirements and the corres ponding regulations at 19 CFR 12.118 through 61 12.127; see also 19 CFR 127.28. Those persons mu st certify that the shipment of the 62 chemical substance complies with all appli cable rules and orders under TSCA, including 63 any SNUR requirements. The EPA policy in su pport of import certif ication appears at 40 64 CFR part 707, subpart B. In addition, a ny persons who export or intend to export a 65 chemical substance that is the subject of th is rule are subject to the export notification 66 provisions of TSCA section 12(b) (15 U.S.C. 2611(b)), (see 40 CFR 721.20), and must 67 comply with the export notification requi rements in 40 CFR part 707, subpart D. 68 To determine whether you or your business may be affected by this action, you 69 should carefully examine the applicabili ty provisions in 40 CFR 721.5 and 40 CFR 70 721.10299. If you have any questions regarding the applicability of this action to a 71 particular entity, consult the technical person listed under FOR FURTHER 72 INFORMATION CONTACT

. 73 B. What is the Agency's Aut hority for Taking this Action? 74*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 4 of 30 Section 5(a)(2) of TSCA (15 U.S. C. 2604(a)(2)) authorizes EPA to determine that 75 a use of a chemical substance is a “si gnificant new use.” EPA must make this 76 determination by rule after c onsidering all releva nt factors, includi ng those listed in 77 TSCA section 5(a)(2). Once EPA determines that a use of a chemical substance is a 78 significant new use, TSCA section 5(a)(1)(B) requires persons to submit a significant 79 new use notice (SNUN) to EPA at least 90 days before they manufacture or process the 80 chemical substance for that use (15 U.S.C. 2604(a)(1)(B)). As described in Unit V., the 81 general SNUR provisions are found at 40 CFR Part 721, Subpart A. 82 C. What Action is the Agency Taking? 83 In the Federal Register of July 12, 2011 (76 FR 40850) (FRL-8877-8), EPA 84 proposed a SNUR for 14 ethylene glycol ethers (Ref. 1). EPA’s response to public 85 comments received on the proposed rule appears in Unit X. Please consult the July 12, 86 2011 Federal Register document for further background info rmation for this final rule. 87 This final SNUR applies to seven of th e 14 ethylene glycol ethers identified in 88 the proposed rule. EPA is not finalizing th e SNUR for the other seven ethylene glycol 89 ethers proposed because the Agency believes that these chemicals are not sufficiently 90 similar to the seven chemicals subject to th is SNUR and therefore do not raise the same 91 concern for potential exposure to these chemi cals. (See Unit X.A. for more information.) 92 This final SNUR will require persons to notify EPA at least 90 days before commencing 93 the manufacture (including im port) or processing of: 94

• ethylene glycol dimethyl ether (monoglyme, CASRN 110-71-4) for any use in a 95 consumer product; 96

• diethylene glycol dimethyl ether (diglyme, CASRN 111-96-6) for any use in a 97 consumer product; 98*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 5 of 30 • ethylene glycol diethyl et her (ethylglyme, CASRN 629-14-1) for any use in a 99 consumer product; 100

• diethylene glycol diethyl ether (ethyldi glyme, CASRN 112-36-7) for any use in 101 a consumer product, except as a component of inks, coatings and adhesives, and as a 102 component of paint/graffiti removers; 103

• triethylene glycol dimethyl ether (triglyme, CASRN 112-49-2) for any use in a 104 consumer product, except as a solvent in c onsumer adhesives, in brake fluid, as a 105 component of consumer paint/graffiti removers, and in consumer paints; 106

• diethylene glycol dibutyl ether (butyl diglyme, CASRN 112-73-2) for any use in 107 a consumer product, except as a component of inks, coatings and adhesives, and as a 108 component in soldering compounds; or 109

• triethylene glycol dibutyl ether (but yltriglyme, CASRN 63512-36-7) for any 110

use. 111
D. Why is the Agency Taking this Action? 112 This SNUR is necessary to ensure that EPA receives timely advance notice of any 113 future manufacturing and processing of these ethylene glycol ethers for new uses that 114 may produce changes in human and envir onmental exposures. The rationale and 115 objectives for this SNUR ar e explained in Unit III. 116 E. What are the Estimated Incremental Impacts of this Action? 117 EPA has evaluated the potential co sts of establishing SNUR reporting 118 requirements for potential manufacturers and pr ocessors of the chemical substances 119 included in this final rule. This analysis, whic h is available in the doc ket, is discussed in 120 Unit IX., and is briefly summarized here. 121 In the event that a SNUN is submitted, co sts are estimated to be less than $8,700 122*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 6 of 30 per SNUN submission for large business submitters and $6,300 for small business 123 submitters. These estimates include the co st to prepare and submit the SNUN and the 124 payment of a user fee. In addition, for persons exporting a substance th at is the subject of 125 a SNUR, a one-time notice must be provided fo r the first export or intended export to a 126 particular country, which is estimated to co st less than $100 on aver age per notification. 127 Since EPA is unable to predict whether anyone might engage in future activities that 128 would require reporting, potential total costs were not estimated. 129 II. Overview of the Chemical Subs tances Subject to this Rule 130 The ethylene glycol ethers and the significant new use for each chemical 131 substance subject to this SNURare identified in Table 1. 132 Table 1. Chemicals with Significant New Use(s) 133 Chemical Name Chemical Abstracts (CA) Index Name Chemical Abstracts Service Registry No. (CASRN) Significant New Use(s)

Monoethylene glycol dimethyl ether or monoglyme Ethane, 1,2,-dimethoxy110-71-4 Any use in a consumer product
Diethylene glycol dimethyl ether or diglyme Ethane, 1,1’-oxybis[2-methoxy111-96-6 Any use in a consumer product Diethylene glycol diethyl ether or ethyldiglyme Ethane, 1,1’-oxybis[2-ethoxy112-36-7 Any use in a consumer product except as a component of inks, coatings and adhesives, and as a component of paint/graffiti removers Triethylene glycol dimethyl ether or triglyme 2,5,8,11- Tetraoxadodecane 112-49-2 Any use in a consumer product, except as a solvent in consumer adhesives, in brake fluid, as a component of consumer paint/graffiti removers, and in consumer paints Diethylene glycol dibutyl Butane, 1,1’- [oxybis(2,1- 112-73-2 Any use in a consumer product except as a*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 7 of 30 ether or butyl diglyme ethanediyloxy)]bis- solvent in consumer inks, coatings and adhesives, and as a component in soldering compounds Ethylene glycol diethyl ether or ethylglyme Ethane, 1,2-diethoxy 629-14-1 Any use in a consumer product Triethylene glycol dibutyl ether or butyl triglyme 5,8,11,14- Tetraoxaoctadecane 63512-36-7 Any use

134 EPA notes that the seven chemical substan ces that are the subjects of this SNUR 135 are not the only ethylene glycol ethers thatare of concern based on toxicity. EPA has 136 described the ethylene glycol ethers ca tegory more broadly under the TSCA New 137 Chemicals Program and under Emergency Pl anning and Community Right-To-Know Act 138 (EPCRA) section 313. (See the TSCA New Chemicals Program Chemical Categories 139 document (Ref. 2) and the EPCRA section 313 Li st of Toxic Chemicals “Certain Glycol 140 Ethers” category at 40 CFR 372.65(c) (Ref. 3). Both categories are based on a 141 consideration of structural si milarity and hazard.) These categories are broader than the 142 category that is subject to this SNUR. Fo r this rulemaking, EPA considered past and 143 current patterns of use as one factor in de termining which ethylene glycol ethers would 144 be included within the scope of this SNUR. EPA believes th at the seven ethylene glycol 145 ethers that are the subjects of this SNUR ha ve and/or had similar use patterns and can be 146 anticipated to have at least some similar ne w uses. Thus, given th e potential for similar 147 uses and the potential impact that these will have on type, duration, and magnitude of 148 exposure, EPA believes it is appropriate to focus on these seven ethylene glycol ethers. 149 III. Rationale and Objectiv es for this Final Rule 150 A. Rationale 151 EPA is concerned about the potential of the seven ethylen e glycol ethers that are 152*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 8 of 30 the subjects of this SNUR to cause repr oductive and/or developmental toxicity, 153 genotoxicity and toxicity to blood and blood forming organs a nd believes that individuals 154 could suffer adverse effects from their use (Refs. 1-4). This concern is based on a 155 combination of data and structure-activity relationships. While a specific hazard 156 evaluation is not required by TSCA section 5(a)(2), EPA considered hazard in 157 designating this category of ethylene glycol ethers. In deciding to focus on these 158 chemical substances, EPA considered use patter ns as well as toxicity data and structure159 activity relationships. EPA considered these factors in conjunction with the statutory 160 factors provided in section 5( a)(2). In designating the si gnificant new uses for these 161 chemical substances, EPA will have the opportunity to evaluate and control, where 162 appropriate, activities associatedwith those uses, if such ma nufacturing or processing for 163 the significant new uses were to start or re sume. The required notification provided by a 164 SNUN will provide EPA with the opportunity to evaluate activities associated with a 165 significant new use and an opportunity to pr otect against unreasonable risks, if any, 166 which may occur from exposure to these chemical substances. 167 Consistent with EPA's past practice for issuing SNURs under TSCA section 168 5(a)(2), EPA's decision to issue a SNUR for a particular chemical use need not be based 169 on an extensive evaluation of the hazard, exposure, or potential risk associated with that 170 use. Rather, the Agency's action is based on EP A's determination that if the use begins or 171 resumes, it may present a risk that EP A should evaluate under TSCA before the 172 manufacturing or processing for that use be gins. Since the new use does not currently 173 exist, deferring a detailed consideration of potenti al risks or hazards related to that use is 174 an effective use of resources. If a person decides to begin manufact uring or processing 175 the chemical for the use, the notice allows EPA to evaluate the use according to the 176*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 9 of 30 specific parameters and circumstance s surrounding that intended use. 177 B. Objectives 178 Based on the considerations in Unit III.A., EPA will achieve the following 179 objectives with regard to the significant new uses that are designated in this rule: 180 1. EPA will receive notice of any person’s in tent to manufacture or process any of 181 the chemical substances listed in Table 1 for the described significant new use before that 182 activity begins. 183 2. EPA will have an opportunity to revi ew and evaluate data submitted in a 184 SNUN before the notice submitter begins manufacturing or processing the chemical 185 substances listed in Table 1 for the described significant new use. 186 3. EPA will be able to regulate the pros pective manufacture or processing of the 187 chemical substances before the described si gnificant new use of th e chemical substance 188 listed in Table 1 occurs, provided that regula tion is warranted pursuant to TSCA sections 189 5(e), 5(f), 6 or 7. 190 IV. Significant New Use Determination 191 Section 5(a)(2) of TSCA states that EPA' s determination that a use of a chemical 192 substance is a significant new us e must be made after consider ation of all relevant factors 193 including: 194

• The projected volume of manufacturing a nd processing of a chemical substance. 195

• The extent to which a use changes the type or form of exposure of human beings 196 or the environment to a chemical substance. 197

• The extent to which a use increases th e magnitude and duration of exposure of 198 human beings or the environment to a chemical substance. 199

• The reasonably anticipated manner and methods of manufacturing, processing, 200*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 10 of 30 distribution in commerce, and disposal of a chemical substance. 201 In addition to these factors enumerated in TSCA section 5(a)(2), the statute 202 authorizes EPA to consider a ny other relevant factors. 203 To determine what would constitute a significant new use of the chemical 204 substances subject to this rule, as discusse d herein, EPA considered relevant information 205 about the potential toxicity of these substances, the range of uses for these chemicals and 206 the four factors listed in section 5(a)(2) of TSCA. 207 EPA believes that potential new consumer uses could change the type and form of 208 exposure and/or the magnitude and duration of exposure to humans and the environment 209 relative to what currently exists. Use in c onsumer products could re sult in different types 210 of exposure, e.g., inhalation exposure through sp ray applications, dermal exposure if the 211 consumer product is meant to be hand-applied to an object, than curr ently exist. Use in 212 different consumer products can also change the duration of exposure, which will depend 213 upon the type of consumer product in which th e chemical substance is used. Also, new 214 uses of any of these chemical substances would likely result in an increase of the 215 magnitude of exposure relative to current exposures given th at these uses would be in 216 addition to ongoing uses. Consumers use a variety of products; thus, their potential 217 exposures to a chemical substance in mu ltiple consumer products would likely be 218 additive. 219 New uses in consumer products would also result in differenc es in the processing 220 of the chemical substances that are the s ubject of this SNUR because these chemical 221 substances may be mixed with other chemi cals and may be made part of consumer 222 products with different prope rties, e.g., different viscos ities from existing consumer 223 products. Based on these considerations of the statutory factors, EPA has determined that 224*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 11 of 30 the uses identified in Table 1 are significan t new uses. In additi on, because there are no 225 current uses of triethylene gl ycol dibutyl ether, any new use would result in a change in 226 the volume of manufacturing and processing of this chemical substance, as well as the 227 type, form, magnitude and duration of e xposure, and the manner and methods of 228 manufacturing, processing, distribution in co mmerce, and disposal of this chemical 229 substance. 230 V. Applicability of General Provisions 231 General provisions for SNURs appear under 40 CFR part 721, subpart A. These 232 provisions describe persons subject to the ru le, recordkeeping requirements, exemptions 233 to reporting requirements, and applicability of the rule to uses occurring before the 234 effective date of the final rule. 235 Provisions relating to user fees appe ar at 40 CFR part 700. According to 40 CFR 236 721.1(c), persons subject to SNURs must comp ly with the same notice requirements and 237 EPA regulatory procedures as submitters of Premanufacture Notices (PMNs) under 238 TSCA section 5(a)(1)(A). In particular, these requirements include the information 239 submissions requirements of TSCA section 5(b) and 5(d)(1), the exemptions authorized 240 by TSCA section 5(h)(1), (h)(2), (h)(3), and (h)(5), and the regulations at 40 CFR part 241 720. Once EPA receives a SNUN, EPA may take regulatory action under TSCA section 242 5(e), 5(f), 6 or 7 to control the activities on which it has received the SNUN. If EPA does 243 not take action, EPA is required under TS CA section 5(g) to explain in the Federal 244 Register its reasons for not taking action. 245 Persons who export or intend to export a chemical substance( s) identified in a 246 proposed or final SNUR are s ubject to the export notificati on provisions of TSCA section 247 12(b). The regulations that interpret TSCA section 12(b) appear at 40 CFR part 707, 248*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 12 of 30 subpart D. Persons who import a chemical s ubstance are subject to the TSCA section 13 249 import certification requirements, codifi ed at 19 CFR 12.118 through 12.127; see also 19 250 CFR 127.28. Such persons must certify that the shipment of the chemical substance 251 complies with all applicable rules and orders under TSCA, including any SNUR 252 requirements. The EPA policy in support of im port certification appears at 40 CFR part 253 707, subpart B. 254 VI. Applicability of the Rule to Uses Occurring Before Effective Date of the Final 255 Rule 256 As discussed in the Federal Register of April 24, 1990 (55 FR 17376), EPA has 257 decided that the intent of s ection 5(a)(1)(B) of TSCA is best served by designating a use 258 as a significant new use as of the date of publication of the pr oposed rule rather than as of 259 the effective date of the final rule. If us es begun after publication of the proposed rule 260 were considered ongoing rather than new, it would be difficult for EPA to establish 261 SNUR notice requirements, because a person could defeat the SNUR by initiating the 262 proposed significant new use before the rule became final, and then argue that the use 263 was ongoing as of the effective date of the fi nal rule. Thus, persons who may have begun 264 commercial manufacture or proces sing of the chemical substance(s) subject to this rule 265 after the proposal was published on July 12, 2011, must cease such activity before the 266 effective date of this final rule. To resume their activities, these persons will have to 267 comply with all applicable SNUR notice requirements and wait until the notice review 268 period, including all extensions, expires. Uses arising after th e publication of the 269 proposed rule are distinguished from uses that exist at publication of the proposed rule. 270 The former would be new uses, the latter ongoing uses. To the extent that additional 271 ongoing uses were found in the course of rule making, EPA has excluded these uses from 272*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 13 of 30 the final SNUR. EPA promulgated provisions to allow persons to comply with this 273 SNUR before the effective date. If a pers on were to meet the conditions of advance 274 compliance under section 721.45(h), that person would be considered to have met the 275 requirements of the final SNUR for those activities. 276 VII. Test Data and Other Information 277 EPA recognizes that TSCA section 5 doe s not usually require developing any 278 particular test data before submission of a SNUN. There are two exceptions: 1) 279 development of test data is re quired where the chemical substance subject to the SNUR is 280 also subject to a test rule under TSCA section 4 (see TSCA section 5(b)(1)); and 2) 281 development of test data may be necessary wh ere the chemical substance has been listed 282 under TSCA section 5(b)(4) (see TSCA section 5(b)(2)). In the absence of a section 4 283 test rule or a section 5(b)(4) listing covering the chemical s ubstance, persons are required 284 only to submit test data in their possession orcontrol and to desc ribe any other data 285 known to or reasonably ascertainable by them (15 U.S.C. 2604(d); 40 CFR 721.25, and 286 40 CFR 720.50). However, as a general matte r, EPA recommends that SNUN submitters 287 include data that would permit a reasoned evaluation of risks posed by the chemical 288 substance during its manufacture (including import), processing, us e, distribution in 289 commerce, or disposal. EPA encourages pe rsons to consult with the Agency before 290 submitting a SNUN. As part of this optiona l pre-notice consultation, EPA would discuss 291 specific data it believe s may be useful in evaluating a significant new use. SNUNs 292 submitted for significant new uses without any test data may increase the likelihood that 293 EPA will take action under TSCA section 5(e) to prohibit or limit activities associated 294 with this chemical substance. 295 SNUN submitters should be aware thatEPA will be better able to evaluate 296*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 14 of 30 SNUNs that provide deta iled information on: 297 1. Human exposure and environmental re leases that may result from the 298 significant new uses of the chemical substance. 299 2. Potential benefits of the chemical substance. 300 3. Information on risks posed by the chemical substances compared to risks posed 301 by potential substitutes. 302 VIII. SNUN Submissions 303 EPA recommends that entities consult with the Agency prior to submitting a 304 SNUN to discuss what data may be useful in evaluating a sign ificant new use. 305 Discussions with the Agency prior to submission can afford ample time to conduct any 306 tests that might be helpful in evaluating ri sks posed by the intended use of the chemical 307 substance. According to section 721.1(c), persons submitting a SNUN must comply with 308 the same notice requirements and EPA regul atory procedures as persons submitting a 309 PMN, including submission of test data on he alth and environmental effects as described 310 in § 720.50. SNUNs must be submitted on EP A Form No. 7710-25, generated using e311 PMN software, and submitted to the Agency in accordance with the procedures set forth 312 in §§ 721.25 and 720.40. E-PMN software is available electronically at 313 http://www.epa.gov/opptintr/newchems

. 314 IX. Economic Analysis 315 A. SNUNs 316 EPA has evaluated the potential co sts of establishing SNUR reporting 317 requirements for potential manufacturers and processors of the chemical substance 318 included in this rule (Ref. 5). In the even t that a SNUN is submitted, costs are estimated 319 at approximately $8,589 per SNUN submissi on for large business submitters and $6,189 320*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 15 of 30 for small business submitters. These estimates include the cost to prepare and submit the 321 SNUN, and the payment of a user fee. Busi nesses that submit a SNUN would be subject 322 to either a $2,500 user fee re quired by 40 CFR 700.45(b)(2)(iii) , or, if they are a small 323 business with annual sales of less than $40 million when combined with those of the 324 parent company (if any), a reduced user f ee of $100 (40 CFR 700.45(b)(1)). The costs of 325 submission of SNUNs will not be incurred by any company unless a company decides to 326 pursue a significant new use as defined in this SNUR. EPA's complete economic 327 analysis is available in the public docket for this rule (Ref. 5) 328 B. Export Notification 329 Under section 12(b) of TSCA and the implementing regulations at 40 CFR part 330 707, subpart D, exporters must notify EPA if th ey export or intend to export a chemical 331 substance or mixture for which, among othe r things, a rule has been proposed or 332 promulgated under section 5. For persons expor ting a substance that is the subject of a 333 SNUR, a one-time notice must be provided for the first export or intended export to a 334 particular country. The total costs of export notifi cation will vary by chemical substance, 335 depending on the number of required notifications (i.e., the number of countries to which 336 the chemical substance is exported). EPA is unable to make any estimate of the likely 337 number of export notifications for the chemical substances covered in this SNUR. 338 X. Response to Comments 339 The Agency reviewed and considered all comments received related to the 340 proposed rule. Copies of all non-CBI comment s are available in the docket for this action 341 (EPA-HQ-OPPT-2009-0767). A discussion of the major comments germane to the 342 rulemaking and the Agency’s responses follow. Responses to all germane comments 343 received are in the document titled: Response to Comments on the Proposed Ethylene 344*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 16 of 30 Glycol Ethers (Glymes) Signifi cant New Use Rule (SNUR) (Ref. 6), which is also 345 available in the docket. 346 A. Scope of Ethylene Glycol Ethers Category. 347 Comment 1: One commenter contends that the term glymes, while technically 348 correct, is a less well-known term for thes e ethylene glycol ethers. The commenter 349 asserts it may not have been clear to many wh at chemicals are subject to this rulemaking. 350 Response 1: EPA disagrees that it was unclear what chemical substances were 351 the subjects of the proposed SNUR. Even if an individual manufacturer or processor 352 were unfamiliar with the term EPA used to designate the category (“ glymes”), all of the 353 chemical substances proposed to be incl uded in the SNUR were also individually 354 identified by their CASRN, CA Index Name , and ethylene glycol ether common name. 355 Notice of the proposal was adequate; there we re several ways in which stakeholders 356 could have determined which chemical subs tances were the subjects of the proposal. 357 However, to increase clarity, EPA will list the “ethylene glycol ether” name instead of the 358 name “glymes” to characterize the chemicals subject to this SNUR. 359 Comment 2: One commenter contends that while the ethylene glycol ethers are 360 structurally similar, they vary in molecular weight, in the number of ethylene glycol 361 groups, and in the length of the terminal alky l groups. The commenter asserts that the 362 presence of characteristics, such as longer te rminal alkyl groups and more ethylene glycol 363 groups act to reduce the developmental and re productive toxicity of the higher molecular 364 weight ethylene glycol ethers, as compared to the lower molecular weight ethylene glycol 365 ethers. The commenter states that there is a decrease in ethylene glycol ether toxicity 366 with increasing terminal alkyl length and/orincreasing ethylene gl ycol groups, and that 367 the category should be limited to monoglym e, diglyme and ethylglyme. Another 368*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 17 of 30 commenter contends that the category s hould be limited based on a consideration of 369 metabolism. The commenter contends that th e category should be limited to monoglyme, 370 diglyme, ethyl diglyme and triglyme because only these will be metabolized in the body 371 to chemical substances that have toxicity characteristics of ethylen e glycol monomethyl 372 ether and ethylene glycol monoethyl ether. The commenter conte nds that none of the 373 other ethylene glycol ethers e xhibit developmental or reproductive toxicity similar to that 374 of these four chemical substances. 375 Response 2: A specific evaluation of hazard is not required by TSCA section 376 5(a)(2) to issue a SNUR. Nonetheless, EPA has based this SNUR in part on 377 considerations of toxicity, so toxicity consid erations are relevant in this instance. 378 EPA believes that based on both toxicity da ta and structure-activity relationships 379 (Refs. 1-4) ethylene glycol ethers that c onsist of 1, 2 or 3 glycol ether groups and 380 terminal alkyl groups of 1 to 4 carbons can be anticipated to cau se developmental and 381 reproductive toxicity and/or hemolytic toxicit y. Based on these same data and structure382 activity relationships, EPA agrees with comment ers that chemical substances with more 383 than 3 repeating glycol ether units should not be included in the category because the 384 toxicity of such substances is dissimilar fr om the remaining members of the category. 385 Therefore, EPA removed seven of the proposed category members from the final rule. 386 While there is evidence that the toxicity is reduced going from methyl to butyl 387 ether and with increasing number of ethylen e glycol groups, toxicity is still observed 388 (Refs. 3, 4). Indeed, data provided by one commenter demonstrate the developmental 389 toxicity of six of the seven ethylene glycol ethers (Ref. 7) . Among the seven substances 390 listed in Table 1, EPA disagrees that the rele vant evidence establishes sufficient variation 391 in degree of toxicity to cull any further substances from the group. Differing doses at 392*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 18 of 30 which toxicity occurs does not equate with lack of toxicity. T hus, EPA disagrees with 393 the commenter that the category should be further limited to only those chemicals which 394 induce toxicity at the lowest doses. Inclusion in the categor y is appropriately predicated 395

on similarity of toxicity. (EPA notes also that th e commenters’ individua l lists are not in 396 agreement with respect to ethylene glycol et hers that they consider to be the most 397 developmentally toxic, and that there is onl y partial overlap between these two lists.) 398 Further, ethylene glycol ethers cause a dverse effects in addition to reproductive 399 and developmental toxicity. Data for other t oxic effects of ethylene glycol ethers with 400 terminal alkyl groups of one to four carbons do not indicate a trend toward decreasing 401 toxicity with increasing alkyl chain length (Ref. 4). Hemolysis has been reported in 402 varying degrees for ethylene glycol ethers of one to five carbons in the alkyl chains (Ref. 403 4). Hemolysis is associated with chain length, and a chain length of four carbons causes 404 this type of toxicity at the lowest dose (Ref. 4). 405 One commenter contends that “the lower glymes that are generally considered to 406 be toxic following repeated exposure are: monoglyme, diglyme and ethylglyme. The 407 higher glymes that are less toxic following re peated exposure are triglyme, tetraglyme, 408 polyglyme, ethyldiglyme and butyldiglyme” (R ef. 7). EPA disagrees that molecular 409 weight can be appropriately applied, by its elf, to establish which substances are 410 sufficiently similar to be included in the SNUR . EPA notes that some level of variation 411 within chemical categories is inevitable wh en placing similar chemicals into groups, and 412 therefore, variation is expected. The similarity in the toxicity of th e chemical substances 413 that are the subject of this SNUR is not primarily based on molecular weight but as 414 discussed above is based on both toxicity dataand structure-activity relationships (Refs 415 1-4). Ethylene glycol ethers that consist of 1, 2 or 3 glycol ether groups and terminal 416*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 19 of 30 alkyl groups of 1 to 4 carbons can be an ticipated to cause developmental and 417 reproductive toxicity and/or hemolytic toxicit y. Based on these toxi city considerations, 418 EPA notes that it did, in fact remove some of the higher molecular weight ethylene glycol 419 ethers from the final rule. But EPA disagrees that varying molecular weight, in itself, 420 should be a deciding factor in eliminating a chemical substance from a category of 421 similar chemical substances. While the commenter provides limited data on 422 developmental and reproductive toxicity, they provide no data with respect to other 423 toxicity endpoints of concer n (including toxicity to blood and blood forming organs, and 424 potential for gene mutation) and the commenter does not speculate on possible 425 similarities or differences among the chemical substances with respect to these endpoints 426 (Ref. 7). 427 Comment 3: Several commenters contend th at the ethylene glycol ether category 428 is too broad. While the chemical substances in the category are similar because they have 429 one or more repeating glycol ether groups and terminal alkyl chains, structural similarity 430 is not sufficient to predict toxicity. One commenter further states that structural 431 similarities alone should not be the basis for toxicity determinations, risk assessment and 432 subsequent regulation. 433 Response 3: EPA acknowledges the commenter s’ assertions that the category of 434 ethylene glycol ethers in th e proposed SNUR was too broad, and is finalizing this SNUR 435 for only seven of the original 14 chemicals. 436 The commenters’ remaining arguments (about the relevan ce of structural 437 similarities to risk assessment, and subsequentregulation) are premature. This SNUR is 438 not based on a risk assessment, and it does not establish that subseque nt regulation of the 439*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 20 of 30 ethylene glycol ethers would be necessary in the event EPA recei ves a significant new 440 use notice after promulgating this rule. 441 While EPA did consider toxicity in deciding to focus on these chemical 442 substances, under TSCA section 5(a)(2), EPA is neither required to determine that a 443 particular new use of any chemical substance presents, nor even that it may present, an 444 unreasonable risk to human health or the envi ronment. Rather, EPA issues a SNUR for a 445 particular new use of a substance if it has reason to anticipate th at the use would raise 446 significant questions related to potential exposure, so that it should have an opportunity to 447 review the use before such use could occur. EPA bases this judgment on a consideration 448 of all relevant factor s, including the specific factors iden tified at section 5(a)(2). EPA 449 considered similarities in toxicity and potential toxicity among these chemical 450 substances, similarities in uses and consid ered the extent to which the significant new 451 uses that are the subject of this SNUR coul d result in changes to the processing of these 452 chemical substances and the type, durati on and magnitude of exposures to these 453 chemicals. 454
B. Use. 455 Comment 4: Two commenter s request clarification on whether automobiles are 456 considered consumer products. These commen ters point to the definition of consumer 457 product at section 3(a)(5) of the Consumer Product Safety Act (CPSA), which excludes 458 motor vehicles. These commenters conte nd that the EPA definition at 40 CFR 721.3 459 should be clarified to be consistent with CPSA and exclude motor vehicles. 460 Response 4: CPSA is a di fferent statute from TSCA. For purposes of significant 461 new use rules issued pursuant to TSCA, c onsumer product is defined at 40 CFR 721.3 as 462 “...a chemical substance that is directly, or as part of a mixture, soldor made available to 463*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 21 of 30 consumers for their use in or around a permanen t or temporary household or residence, in 464 or around a school, or in recreati on.” This is the pertinent re gulatory text and it contains 465 no exclusion for automobiles. 466 However, EPA would not consider ethylene glycol ethers to have been “sold or 467 made available to consumers for their use” merely because they have been sold or made 468 available to automobile manufacturers or co mmercial auto service establishments (for 469 their use in manufacturing or maintaining cu stomers’ motor vehicl es). By contrast, 470 ethylene glycol ethers that are sold or made available to a consumer, for the consumer’s 471 own use in maintaining his or her own motor ve hicle (e.g., as part of an aftermarket brake 472 fluid) would fall within the de finition of “consumer product.” 473 Comment 5: One commenter asks that EPA clarify the status of brake fluid 474 contained in a new or used mo tor vehicle at point of sale. 475 Response 5: EPA would not consider an et hylene glycol ether to have been “sold 476 or made available to consumers for their use, ” merely because it has been made available 477 to motor vehicle manufacturers (as part of a brake fluid mixture for their use in 478 manufacturing customers’ motor vehicles) or used car dealers. By contrast, ethylene 479 glycol ethers that are sold or made available to a consumer, for the consumer’s own use 480 in maintaining his or her own motor vehicle (e .g., as part of an aftermarket brake fluid) 481 would fall within the definition of “consumer product.” 482 Comment 6: One commenter requestedthat EPA clarify how aftermarket 483 components are addressed in this rulemaking. 484 Response 6: An aftermarket componen t is any product offered for sale or 485 installation in or on a motor vehicle after such vehicle has left the manufacturer's 486 production line. Use in an aftermarket co mponent would qualify as use in a consumer 487*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 22 of 30 product if the chemical substa nces in an aftermarket component are “sold or made 488 available to consumers for their use in oraround a permanent or temporary household or 489 residence, in or around a school, or in recreation.” 40 CFR 721.3. 490 Comment 7: Two commenter s request that EPA modi fy the listed ongoing use 491 for monoethylene glycol dimethyl ether (m onoglyme) listed in the proposed rule - “any 492 use in a consumer product except in electrolyt e solution in sealed lithium batteries” to 493 “any use in a consumer product except in elec trolyte solutions for primary and secondary 494 sealed lithium batteries” - because this w ould clarify that the ongoing use of monoglyme 495 is in all primary and secondary batteries. 496 Response 7: For purposes of defining the scope of the significant new use, EPA 497 has determined that the use of ethylene glycol ethers in sealed lithium batteries (whether 498 primary or secondary) is not use in a consumerproduct. An ethylene glycol ether is not 499 being “sold or made available to consumers for their use,” 40 CF R 721.3, merely because 500 it is contained in the electrol yte of sealed lithium batteries , which are themselves used by 501 consumers. With this clarification, EP A is finalizing the significant new use for 502 monoethylene glycol dimethyl ether as “any use in a consumer product.” 503 XI. References 504 The following is a listing of the documents that are specifically referenced in this 505 document. The docket includes these docum ents and other information considered by 506 EPA in developing this rule, including the documents referenced within the documents 507 that are in the docket, even if the referenced document is not physically located in the 508 docket. For assistance in locating these othe r documents, please consult the technical 509 person listed under FOR FURTHER INFORMATION CONTACT

. 510 1. US EPA. Glymes; Proposed Significant New Use Rule. 76 FR 40850, July 12, 511*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 23 of 30 2011. 512 2. US EPA. TSCA New Chemicals Program (NCP) Chemical Categories. Last 513 revised August 2010, pages 68 – 69. 514 http://www.epa.gov/oppt/newchems/ pubs/npcchemicalcategories.pdf. 515 3. US EPA. Glycol Ethers Category; Toxic Chemical Release Reporting; 516 Community Right-To-Know. 58 FR 36180, July 6, 1993. 517 4. US EPA. Glycol Ethers Category; Toxic Chemical Release Reporting; 518 Community Right-To-Know. 59 FR 34386, July 5, 1994. 519 5. US EPA. Economic Analysis of th e Significant New Use Rule for Seven 520 Ethylene Glycol Ethers. Prepared by Ni shkam Agarwal and Abt Associates Inc. 521 September 30, 2013. 522 6. US EPA. Response to Comments on the Proposed Ethylene Glycol Ethers 523 (Glymes) Significant New Use Rule (SNUR). October 30, 2013. 524 7. Novolyte Technologies. Attachment 1: Categorization of Glymes Based on 525 Toxicology and Structural Characteri stics. October 12, 2011, pages 1-21. 526 XII. Statutory and Executive Order Reviews 527 A. Executive Order 12866: Regulatory Planning and Review and Executive Order 13563: 528 Improving Regulation and Regulatory Review 529 This final rule has been designated by OMB as a “significa nt regulatory action” 530 under section 3(f) of Executive Orde r 12866 (58 FR 51735, October 4, 1993). 531 Accordingly, EPA submitted this action to OMB for review under Executive Orders 532 12866 and 13563 (76 FR 3821, January 21, 2011) and any changes made in response to 533 OMB recommendations have been documented in the docket for this action. 534 B. Paperwork Reduction Act (PRA) 535*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 24 of 30 This action does not impose any new in formation collection burden under the 536 PRA, 44 U.S.C. 3501 et seq. Burden is defi ned in 5 CFR 1320.3(b). The information 537 collection activities associated with exis ting chemical SNURs are already approved by 538 OMB under OMB control number 2070-0038 (EPA ICR No. 1188); and the information 539 collection activities a ssociated with export notifications are already approved by OMB 540 under OMB control number 2070-0030 (EPA ICR N o. 0795). If an entity were to submit 541 a SNUN to the Agency, the annual burden is estimated to be less than 100 hours per 542 response, and the estimated burden for an e xport notifications is less than 1.5 hours per 543 notification. In both cases, burden is estimatedto be reduced for submitters who have 544 already registered to use the electronic submission system. Additional burden, estimated 545 to be less than 10 hours, coul d be incurred where additional record keeping requirements 546 are specified under 40 CFR §721.12 5(a), (b), and (c). 547 An agency may not conduct or sponsor, and a person is not required to respond to 548 a collection of information that requires OM B approval under the PRA, unless it has been 549 approved by OMB and displays a currentl y valid OMB control number. The OMB 550 control numbers for EPA's regulations in Titl e 40 of the CFR, after appearing in the 551 Federal Register , are listed in 40 CFR, part 9, a nd included on the related collection 552 instrument, or form, if applicable. EPA is am ending the table in 40 CFR part 9 to list this 553 SNUR. This listing of the OMB control numbers and their subsequent codification in the 554 CFR satisfies the display requirements of the PRA and OMB's implementing regulations 555 at 5 CFR part 1320. Since the existing OMB approval was previously subject to public 556 notice and comment before OMB approval, and given the technical nature of the table, 557 EPA finds that further notice and comment to amend the table is unnecessary. As a 558 result, EPA finds that there is “good cause” under section 55 3(b)(3)(B) of the 559*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 25 of 30 Administrative Procedure Act (5 U.S.C. 553(b )(3)(B)) to amend this table without further 560 notice and comment. 561 C. Regulatory Flexibility Act (RFA) 562 Pursuant to section 605(b) of the RFA, 5 U.S.C. 601 et seq., I hereby certify that 563 promulgation of this SNUR will not have a significant economic impact on a substantial 564 number of small entities. The rationale supporting this conclusion is as follows. 565 A SNUR applies to any pers on (including small or large entities) who intends to 566 engage in any activity describe d in the rule as a “significan t new use.” By definition of 567 the word “new” and based on all information cu rrently available to EPA, it appears that 568 no small or large entities presently engage in such activities. Since this SNUR will 569 require a person who intends to engage in such activity in the future to first notify EPA 570 by submitting a SNUN, no economic impact will occur unless someone files a SNUN to 571 pursue a significant new use in the future or forgoes profits by avoiding or delaying the 572 significant new use. Although some small en tities may decide to engage in such 573 activities in the future, EPA cannot presently determine how many, if any, there may be. 574 However, EPA’s experience to date is that , in response to the promulgation of SNURs 575 covering over 1,000 chemical substances, the Agency receives only a handful of notices 576 per year. During the six year period from 2005-2011, only three submitters self577 identified as small in their SNUN submi ssion (Ref. 5). EPA believes the cost of 578 submitting a SNUN is relatively small compared to the cost of developing and marketing 579 a chemical new to a firm and that the requi rement to submit a SNUN generally does not 580 have a significant economic impact. 581 Therefore, EPA believes that the potentia l economic impact of complying with 582 this SNUR is not expected to be significan t or adversely impact a substantial number of 583*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 26 of 30 small entities. In a SNUR that published as a final rule on August 8, 1997 (62 FR 42690) 584 (FRL-5735-4), the Agency presented its gene ral determination that proposed and final 585 SNURs are not expected to have a signifi cant economic impact on a substantial number 586 of small entities, which was provided to th e Chief Counsel for Advocacy of the Small 587 Business Administration. 588 D. Unfunded Mandates Reform Act (UMRA) 589 Based on EPA’s experience with proposi ng and finalizing SNURs, State, local, 590 and Tribal governments have not been imp acted by these rulemakings, and EPA does not 591 have any reason to believe that any State, lo cal, or Tribal government would be impacted 592 by this rulemaking. As such, EPA has determined that this regul atory action would not 593 impose any enforceable duty, contain any unfunded mandate, or otherwise have any 594 effect on small governments subject to th e requirements of sections 202, 203, 204, or 205 595 of UMRA, 2 U.S.C. 1531-1538. 596 E. Executive Order 13132: Federalism 597 This action does not have a substantial di rect effect on States , on the relationship 598 between the national government and the Stat es, or on the distribution of power and 599 responsibilities among the various levels of government, as specified in Executive Order 600 13132 (64 FR 43255, August 10, 1999). 601 F. Executive Order 13175: Consultation and Coordination with Indian Tribal 602
Governments 603 This rule does not have Tribal impli cations because it will not have any effect 604 (i.e., there will be no increase or decrease in authority or jurisdiction) on Tribal 605 governments, on the relationship between the Federal government and the Indian tribes, 606 or on the distribution of power and responsib ilities between the Federal government and 607*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 27 of 30 Indian tribes. Thus, Executive Order 13175 (65 FR 67249, November 9, 2000) does not 608 apply to this action. 609 G. Executive Order 13045: Protection of Childre n from Environmental Health Risks and 610 Safety Risks 611 This action is not subject to Executive Order 13045 (62 FR 19885, April 23, 612 1997), because this action is not intended to ad dress environmental health or safety risks 613 for children. 614 H. Executive Order 13211: Actions that Significantly Affect Energy Supply, Distribution, 615
or Use 616 This rule is not subject to Ex ecutive Order 13211 (66 FR 28355, May 22, 2001), 617 because this action is not expected to a ffect energy supply, distribution, or use. 618 I. National Technology Transfe r Advancement Act (NTTAA) 619 Since this action does not involve any t echnical standards, NTTAA section 12(d), 620 15 U.S.C. 272 note, does not apply to this action. 621 J. Executive Order 12898: Federal Actions to Address Environmental Justice in Minority 622 Populations and Low-Income Populations 623 This action does not entail sp ecial considerations of environmental justice related 624 issues as delineated by Executive Order 12898 (59 FR 7629, February 16, 1994), because 625 EPA has determined that this action will not have disproportionately high and adverse 626 human health or environmental effects on minority or low-income populations. This 627 action does not affect the level of protection provided to human health or the 628 environment. 629 XIII. Congressional Review Act (CRA) 630 Pursuant to the CRA, 5 U.S.C. 801 et seq. , EPA will submit a report containing 631*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 28 of 30 this rule and other required information to the U.S. Senate, the U.S. House of 632 Representatives, and the Comptroller General of the United States prior to publication of 633 the rule in the Federal Register . This action is not a “major rule” as defined by 5 U.S.C. 634 804(2). 635 List of Subjects 636 40 CFR Part 9 637 Environmental protection, Reporting and recordkeeping requirements. 638 40 CFR Part 721 639 Environmental protection, Chemicals, Hazardous substances, Reporting and 640 recordkeeping requirements. 641 Dated: _______________________ 642 643

_______________________________________________ 644 Director, Office of Pollution Prevention and Toxics. 645*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 29 of 30 Therefore, 40 CFR parts 9 and 721 are amended as follows: 646 PART 9--[AMENDED] 647 1. The authority citation for part 9 continues to read as follows: 648 Authority: 7 U.S.C. 135 et seq ., 136-136y; 15 U.S.C. 2001, 2003, 2005, 2006, 649 2601-2671; 21 U.S.C. 331j, 346a, 348; 31 U.S.C. 9701; 33 U.S.C. 1251 et seq ., 1311, 650 1313d, 1314, 1318, 1321, 1326, 1330, 1342, 1344, 1345 (d) and (e), 1361; E.O. 11735, 651 38 FR 21243, 3 CFR, 1971-1975 Comp. p. 973; 42 U.S.C. 241, 242b, 243, 246, 300f, 652 300g, 300g-1, 300g-2, 300g-3, 300g-4, 300g-5, 300g-6, 300j-1, 300j-2, 300j-3, 300j-4, 653 300j-9, 1857 et seq ., 6901-6992k, 7401-7671q, 7542, 9601-9657, 11023, 11048. 654 2. In § 9.1, add the following sections in numer ical order under the undesignated 655 center heading “Significant New Uses of Ch emical Substances” to read as follows: 656 § 9.1 OMB approvals under the Paperwork Reduction Act. 657
* * * * * 658 40 CFR citation OMB control No.

* * * * * Significant New Uses of Chemical Substances * * * * * 721.10229 2070-0038

* * * * * 659 * * * * * 660 PART 721--[AMENDED] 661 3. The authority citation for part 721 continues to read as follows: 662 Authority: 15 U.S.C. 2604, 2607, and 2625(c). 663 4. Add §721.10229 to subpart E to read as follows : 664*** EO 12866/13563 Review – Do Not Cite, Qu ote or Release During the Review *** (RIN 2070-AJ52)

Page 30 of 30 §721.10229 Ethylene Glycol Ethers. 665 (a) Chemical substances and signific ant new uses subject to reporting . (1) The chemical 666 substances identified in Table 1 are subjec t to reporting under this section for the 667 significant new uses de scribed in Table 1 668 Table 1. Ethylene glycol ethers and signif icant new uses subject to reporting. 669 Chemical Name Chemical Abstracts Index Name Chemical Abstracts Service Registry No. (CASRN) Significant New Use(s)

Monoethylene glycol dimethyl ether or monoglyme Ethane, 1,2,-dimethoxy110-71-4 Any use in a consumer product
Diethylene glycol dimethyl ether or diglyme Ethane, 1,1’-oxybis[2-methoxy111-96-6 Any use in a consumer product Diethylene glycol diethyl ether or ethyldiglyme Ethane, 1,1’-oxybis[2-ethoxy112-36-7 Any use in a consumer product except as a component of inks, coatings and adhesives, and as a component of paint/graffiti removers Triethylene glycol dimethyl ether or triglyme 2,5,8,11- Tetraoxadodecane 112-49-2 Any use in a consumer product, except as a solvent in consumer adhesives, in brake fluid, as a component of consumer paint/graffiti removers, and in consumer paints Diethylene glycol dibutyl ether or butyldiglyme Butane, 1,1’- [oxybis(2,1-ethanediyloxy)]bis112-73-2 Any use in a consumer product except as a solvent in consumer inks, coatings and adhesives, and as a component in soldering compounds Ethylene glycol diethyl ether or ethylglyme Ethane, 1,2- diethoxy 629-14-1 Any use in a consumer product Triethylene glycol dibutyl ether or butyltriglyme 5,8,11,14- Tetraoxaoctadecane 63512-36-7 Any use

670