EXHIBIT 10.100

                    FIRST AMENDMENT TO STOCK PURCHASE WARRANT

     THIS FIRST AMENDMENT TO STOCK PURCHASE WARRANT (the "Agreement") is made as
of the 1st day of August 1996 by and between Biomune Systems, Inc.., a Nevada
corporation (the "Company"), and A.L. Sarroff, an individual (the "Registered
Holder"). The Company and the Registered Holder are sometimes referred to herein
collectively as the "Parties."

                                    RECITALS:

     A. WHEREAS, on January 31, 1995, pursuant to the terms of a Consulting
Agreement of even date therewith entered into between the Parties, the Company
granted the Registered Holder a Stock Purchase Warrant to purchase from the
Company a total of 125,000 shares of the Company's Common Stock, $0.0001 par
value per share (defined therein as the Warrant Stock), at an exercise price of
$4.00 per share (defined therein as the Exercise Price), as evidenced by
Certificate No. B-1000 ("Warrant B-1000"), a copy of which is attached hereto as
Exhibit "B";

     B. WHEREAS, all capitalized terms used in this Amendment that are not
otherwise defined herein, shall be deemed to have the meanings ascribed to them
in Warrant B-1000;

     C. WHEREAS, the Company and the Registered Holder deem it necessary and
appropriate to amend the Exercise Price of the Warrant Stock in Warrant B-1000;

     D. WHEREAS, the Company and the Registered Holder further deem it necessary
and in their best interests to amend Warrant B-1000 to add a new Section 11 to
Warrant B-1000, which new Section shall be designated as Section 11 to Warrant
B-1000 and which Section 11 will state the terms and limits of a lockup of the
Registered Holder's right to exercise Warrant B-1000 and acquire the Warrant
Stock; and

     F. WHEREAS, the Company is currently contemplating filing a registration
statement with the United States Securities and Exchange Commission (the "SEC")
on Form S-1 or Form S-3 to register certain shares of the Company's Common Stock
(the "Registration Statement"), which Registration Statement is currently
contemplated to be declared effective by the SEC by or about December 31, 1996.

     NOW THEREFORE, in consideration of the foregoing Recitals, together with
other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the Parties agree as follows:

     1. Amendment of Warrant B-1000 Exercise Price. The Exercise Price for
Warrant B-1000 shall be amended to extend to August 1, 2001.

     2. Addition of New Section 11. Warrant B-1000 shall be amended to add a new
Section 11 reading in its entirety as follows

     "SECTION 11. Six Month Lock-Up. Notwithstanding any other provision of this
Warrant, the Registered Holder shall not exercise the purchase rights
represented by this Warrant until the later to occur of (a) six (6) months after
the SEC declares the Registration Statement effective or (b) January 31, 1997."

     3. No Other Amendments. Except as provided in this Amendment, Warrant
B-1000 shall not be deemed to be amended or altered and shall remain in full
force and effect as originally executed. This Amendment shall be deemed to be
effective as of the date first set forth above and shall not be modified or
altered except by a writing signed by the Parties. The above Recitals shall be
deemed to be incorporated herein by this reference.

         DATED August 1, 1996.


                                  THE COMPANY:

                                  BIOMUNE SYSTEMS, INC., a Nevada corporation


                                  By:   /s/  David G. Derrick
                                     --------------------------
                                        David G. Derrick
                                  Its:  Chief Executive Officer


                                  REGISTERED HOLDER:

                                  -----------------------------
                                        /s/  A.L. Sarroff
                                        A.L. Sarroff


Exhibit "B" consists of a Stock Purchase Warrant dated January 31, 1995