Exhibit 10.1





Exhibit 10.1








	AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 11. CONTRACT ID CODE PAGE OF PAGES
I
2. AMENDMENT/MODIFICATION NO: 13. EFFECTIVE DATE 14. REQUISITION/PURC5. PROJECT NO. (If applicable)
Nine (9) See block 16C ........ N/A ........................... N/A
6. ISSUED BY
CODE 7. ADMINISTERED BY {If other than Item 6) CODE|
Biomedical Advanced Research and
Development Authority U.S. Department
of Health and Human Services 330
Independence Avenue, SW Room G640
Washington, DC 20201
8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code) I 19A. AMENDMENT
OF SOLICITATION NO.
BioCryst Pharmaceuticals, Inc. 9B. DATED (SEE ITEM 11)
2190 Parkway Lake
Drive Birmingham,
AL 35244 DUNS
61-819-4609
TIN 62-1413174
10A.MODIFICATION OF
CONTRACT/ORDER
X HHSO100200700032C
10B. DATED (SEE ITEM 13)
CODE FACILITY CODE 01-03-07
11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS
The above numbered solicitation is amended as set forth in Item 14. The hour and date specified
for receipt of Offers ~ is extended, ~ is not extended.
Offers must acknowledge receipt of this amendment prior to the hour and date specified In the
solicitation or as amended, by one of the following methods; (a) By completing Items 8
and 15, and returning copies of the amendment; (b) By acknowledging receipt of this amendment on
each copy of the offer submitted; or (c) By separate letter or
telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR
ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR
AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment, you
desire to change an (sffer already submitted, such change may be made by telegram or letter,
provided each telegram or letter makes reference to the solicitation and this amendment, and is
received prior to the opening hour and date specified.
12. ACCOUNTING AND APPROPRIATION DATA (If required)
SOCC: DOC# TIN# LOC# CAN#
13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS; IT MODIFIES THE CONTRACT/ORDER NO.
AS DESCRIBED IN ITEM
A. THIS CHANGE ORDER IS ISSUED PURSUANT TO:
B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES
(such as changes in paying office,
appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).
C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:
FAR 52.232-20 (April-84) Limitation of Cost
D. OTHER (Specify type of modification and authority)
E. IMPORTANT: Contractor [] is not, [X] is required to sign this document and return 2 copies
to the issuing office.
14. DESCRIPTION OF MODIFICATION (Organized by UCF section headings.
Including solicitation/contract subject matterwhere feasible)
PURPOSE: The purpose of this modification is to:
1. Reflect agreement on the path forward in the advanced development of peramivir (all
future advanced development activities must be limited to i.v. formulation for complicated
influenza); Articles B, F and J of the contract are modified as described in the attached
pages.
2. Add Optional CLIN to purchase Shionogi & Co. Ltd. data as required.
3. Increase the total contract amount by $77,190,718 from $102,661,429 to $179,852,147.
4. Extend the contract completion date by 12 months from December 31,2010 to December 31, 2011.
Except as provided herein, all terms and conditions referenced in item 9A or 10A remain in full force and effect.
15A. NAME AND TITLE OF SIGNER (Type or print) 116A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)
SchuylerT. Eldridge
15B. CONTRACTOR/OFFEROR 115C. DATE SIGNED 16B. UNITED STATES OF AMERICA 16C. DATE SIGNED
BY
(Signature of person authorized to sign) .. (Signature of Contracting Officer)
NSN 7540-01-152-8070 OMB No. 0990—0115 STANDARD FORM 30 (REV. 10-83]