Exhibit 4.22




 





FIRST AMENDMENT TO 1.5% SENIOR CONVERTIBLE NOTE (RS-10)


 


This First Amendment to 1.5% Senior Convertible Note (RS-I 0) (this
"Amendment") is made and entered into as of February 27, 2017, by and between Amyris, Inc., a Delaware corporation
(the "Company") and Total Energies Nouvelles Activites USA (f.k.a. Total Gas & Power USA, SAS) (the "Investor").


 


RECITALS


 


WHEREAS, on March 21, 2016 the Company issued to the Investor
a 1.5% Senior Convertible Note (RS-10) in the principal amount of $3,700,000 (the "Note"), which Note is attached
hereto as Exhibit A.


 


WHEREAS, the Company and the Investor desire to amend the
Note as set forth herein.


 


WHEREAS, pursuant to Section 7 of the Note, the Note may be
amended with the written consent of the Company and the Investor.


 


NOW, THEREFORE, for good and valuable consideration, the receipt
and sufficiency of which is hereby acknowledged, the parties hereby agree as follows:


 


1.         Amendment
of Section 2(b) of the Note. Section 2(b) of the Note is hereby deleted in its entirety and replaced with the following:


 


(b)       Scheduled Payment of
Principal. Unless paid, converted or cancelled and extinguished earlier in accordance with the terms hereof, the Company shall
deliver to the Investor cash in the amount of the Face Amount, together with all accrued and unpaid interest on this Note, on May
15, 2017 (the "Final Maturity Date") and this Note shall be retired and canceled.


 


2.       Amendment
of Section 14 of the Note. Investor hereby designates the following address for purposes of receiving notice under the
Note.:


 


c/o Total Raffinage Chimie


2, place Jean Millier - La Defense 6


92078 Paris La Defense Cedex


France


Attn:


Fax. No.:


Email:


 


With a copy to (which shall not constitute notice):


Legal Department


Total Energies Nouvelles Activites USA


24 Cours Michelet


92800 Courbevoie


France


Attn: Department Head


 






    


     

    




 





3.        Full Force and
Effect. Except as expressly modified by this Amendment, the terms of the Note shall remain in full force and effect.


 


4.        Integration.
This Amendment and the Note constitute the entire agreement and understanding of the parties with respect to the subject matter
hereof, and supersede all prior understandings and agreements, whether oral or written, between or among the parties hereto with
respect to the specific subject matter hereof.


 


5.        Counterparts;
Facsimile. This Amendment may be executed in one (1) or more counterparts, each of which shall be deemed an original, but
all of which together shall constitute one and the same instrument. This Amendment may be executed and delivered by facsimile,
or by email in portable document format (.pdf), and delivery of any signature page by such method will be deemed to have the same
effect as if the original signature had been delivered to the other party.


 


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left blank)


 


 


 



    


     

    




 


IN WITNESS WHEREOF, the parties hereto have executed this
Amendment as of the date first above written.


 


	AMYRIS, INC.
	 	 	 
	 	 	 	 
	
        By:
	
        /s/ John Melo
	 	 	 	 
	
        Name:
	
        John Melo
	 	 	 	 
	
        Title:
	
        President & Chief Executive Officer
	 	 	 	 







 


 


 


[Signature Page to First Amendment to R&D Note]


 






    


     

    

 





IN WITNESS WHEREOF, the parties hereto have executed this
Amendment as of the date first above written.


 


	TOTAL ENERGIES NOUVELLES ACTIVITES USA


	 
	(F.K.A. TOTAL GAS & POWER USA, SAS)	 
	 	 	 	 
	
        By:
	
        /s/ Christophe Vuillez
	 	 	 	 
	
        Name:
	 Christophe Vuillez	 	 	 	 
	
        Title:
	
        Attorney in fact
	 	 	 	 









 


 


 


[Signature Page to First Amendment to R&D Note]


 






    


     

    




 


Exhibit A


 


See attached.