U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention

National Center for Health Statistics

NCHS Data Brief ■ No. 225 ■ November 2015

Viral Hepatitis Among Non-Hispanic Asian Adults in the 

United States, 2011–2014

Deanna Kruszon-Moran, M.S.; Ryne Paulose-Ram, Ph.D.; Maxine Denniston, M.S.P.H.;

and Geraldine McQuillan, Ph.D.

Key findings

Data from the National 

Health and Nutrition 

Examination Survey

● Prevalence of antibody to 

hepatitis A virus (HAV) from 

infection or vaccination was 

higher among non-Hispanic 

Asian adults than non-Hispanic 

white and non-Hispanic black 

adults.

● Prevalence of both past or 

current hepatitis B virus (HBV) 

infection as well as just current 

active HBV infection was 

higher among non-Hispanic 

Asian adults than non-Hispanic 

white, non-Hispanic black, and 

Hispanic adults.

● Prevalence of current 

hepatitis C virus infection 

among non-Hispanic Asian 

adults was lower than the other 

race and Hispanic groups.

● Prevalence of antibody 

to HAV from infection or 

vaccination was greater among 

non-Hispanic Asian adults born 

outside the United States than 

those who were U.S.-born. A 

similar pattern was seen for 

past or current HBV infection.

Hepatitis A (HAV), B (HBV), and C (HCV) viruses are common types of viral 

hepatitis. HBV and HCV infection can lead to liver disease, cancer, and serious 

health consequences. HAV and HBV infections are high among Asian persons, 

especially those born outside the United States (1–3). This report provides 2011–

2014 National Health and Nutrition Examination Survey (NHANES) estimates 

on prevalence of antibody to HAV (from infection or immunization), past or 

current HBV infection, and current HCV infection, by race and Hispanic origin.

Keywords: HAV • HBV • HCV • NHANES

Does prevalence of antibody to hepatitis A virus among nonHispanic Asian adults differ from other race and Hispanic 

groups, and does it vary by birth place?

During 2011–2014, the prevalence of antibody to HAV, which may be due 

to natural infection or immunization, was 36.5% among U.S. adults aged 

Figure 1. Prevalence of antibody to hepatitis A virus among adults aged 18 and over, by race and 

Hispanic origin, and by birth place for non-Hispanic Asian adults, 2011–2014 

1

Significantly different from non-Hispanic Asian adults (p < 0.05). 2

Significantly different from non-Hispanic white adults (p < 0.05). 3

Significantly different from non-Hispanic black adults (p < 0.05). 4

Significantly different from U.S.-born adults (p < 0.05). 

NOTES: Antibody to hepatitis A virus may be due to natural infection or immunization. Access data table for Figure 1 at: 

http://www.cdc.gov/nchs/data/databriefs/db225_table.pdf#1.

SOURCE: CDC/NCHS, National Health and Nutrition Examination Survey, 2011–2014.
NCHS Data Brief ■ No. 225 ■ November 2015

■  2  ■

18 and over (Figure 1). Among non-Hispanic Asian adults, the prevalence of antibody to HAV 

was 70.9%, which was higher than among non-Hispanic white (25.4%) and non-Hispanic black 

(38.0%) adults but was similar to Hispanic (73.1%) adults.

When examining birth place among non-Hispanic Asian adults, the prevalence of antibody to 

HAV was higher among those born outside the United States (76.6%) than among those who were 

U.S.-born (41.3%).

Does prevalence of hepatitis B virus infection (past or current) among

non-Hispanic Asian adults differ from other race and Hispanic groups, 

and does it vary by birth place?

During 2011–2014, the prevalence of HBV infection (past or current) was 4.7% among U.S. 

adults aged 18 and over (Figure 2). Among non-Hispanic Asian adults, the prevalence was 22.6%, 

which was higher than among non-Hispanic white (2.6%), non-Hispanic black (10.2%), and 

Hispanic (3.6%) adults.

More than one-quarter (26.5%) of non-Hispanic Asian adults born outside the United States had 

HBV infection. This percentage was higher than among non-Hispanic Asian adults who were 

U.S.-born (2.7%) (Figure 2).

Figure 2. Prevalence of hepatitis B virus infection (past or current) among adults aged 18 and over, by race and Hispanic 

origin, and by birth place for non-Hispanic Asian adults, 2011–2014

 

* Estimate may be unreliable due to relative standard error greater than 30% and number of positives fewer than 10. 

1

Significantly different from non–Hispanic Asian adults (p < 0.05).

2

Significantly different from non–Hispanic white adults (p < 0.05).

3

Significantly different from non–Hispanic black adults (p < 0.05).

4

Significantly different from U.S.-born adults (p < 0.05).

NOTES: Hepatitis B virus infection, past or current, is indicated by the presence of hepatitis B core antibody. Access data table for Figure 2 at: http://www.cdc.gov/

nchs/data/databriefs/db225_table.pdf#2.

SOURCE: CDC/NCHS, National Health and Nutrition Examination Survey, 2011–2014.
NCHS Data Brief ■ No. 225 ■ November 2015

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Does prevalence of current hepatitis B virus infection among non-Hispanic 

Asian adults differ from other race and Hispanic groups, and does it vary 

by birth place?

During 2011–2014, the prevalence of current active HBV infection was 0.4% among U.S. adults 

aged 18 and over (Figure 3). Among non-Hispanic Asian adults, the prevalence was 3.3%, which 

was higher than among non-Hispanic black (0.8%), non-Hispanic white (0.2%), and Hispanic 

(0.2%) adults.

The prevalence of current HBV infection was 3.7% among non-Hispanic Asian adults born 

outside the United States. This percentage was higher than among non-Hispanic Asian adults who 

were U.S.-born (1.1%) (Figure 3).

Figure 3. Prevalence of current hepatitis B virus infection among adults aged 18 and over, by race and Hispanic origin, 

and by birth place for non-Hispanic Asian adults, 2011–2014

 

* Estimate may be unreliable due to relative standard error greater than 30% and number of positives fewer than 10. 

1

Significantly different from non–Hispanic Asian adults (p < 0.05).

2

Significantly different from non–Hispanic white adults (p < 0.05).

3

Significantly different from non–Hispanic black adults (p < 0.05).

4

Significantly different from U.S.-born adults (p < 0.05).

NOTES: Current hepatitis B virus infection is indicated by the presence of hepatitis B surface antigen. Access data table for Figure 3 at: http://www.cdc.gov/nchs/

data/databriefs/db225_table.pdf#3.

SOURCE: CDC/NCHS, National Health and Nutrition Examination Survey, 2011–2014.
NCHS Data Brief ■ No. 225 ■ November 2015

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Does prevalence of current hepatitis C virus infection among non-Hispanic 

Asian adults differ from other race and Hispanic groups?

During 2011–2014, the prevalence of current HCV infection among U.S. adults aged 18 and over 

was 0.9% (Figure 4). Among non-Hispanic Asian adults, the prevalence was 0.2%, which was 

lower than among non-Hispanic white (0.8%), non-Hispanic black (1.9%), and Hispanic (0.8%) 

adults.

Due to the low prevalence of current HCV infection among non-Hispanic Asian adults and an 

extremely small number of cases, estimates could not be presented by place of birth.

Figure 4. Prevalence of current hepatitis C virus infection among adults aged 18 and over, by race and Hispanic origin, 

2011–2014

 

* Estimate may be unreliable due to relative standard error greater than 30% and number of positives fewer than 10. 

1

Significantly different from non–Hispanic Asian adults (p < 0.05).

2

Significantly different from non–Hispanic white adults (p < 0.05).

3

Significantly different from non–Hispanic black adults (p < 0.05).

NOTES: Current hepatitis C virus infection is indicated by the presence of hepatitis C virus RNA. Access data table for Figure 4 at: http://www.cdc.gov/nchs/data/

databriefs/db225_table.pdf#4.

SOURCE: CDC/NCHS, National Health and Nutrition Examination Survey, 2011–2014.
NCHS Data Brief ■ No. 225 ■ November 2015

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Summary

Prevalence of antibody to HAV, a marker for both immunization and natural infection, was higher 

among both non-Hispanic Asian (70.9%) and Hispanic (73.1%) adults compared with non-Hispanic 

white (25.4%) and non-Hispanic black (38.0%) adults. HAV infection is spread through fecal–oral 

contamination resulting from unhygienic living conditions and is more prevalent in both Latin 

and Asian countries (2). HAV antibody prevalence among U.S.-born non-Hispanic Asian adults 

was lower and more similar to the estimates for the other non-Hispanic race groups.

Prevalence of past or current HBV infection (indicated by hepatitis B core antibody) as well as 

current active HBV infection (indicated by hepatitis B surface antigen) were both higher among 

non-Hispanic Asian adults than among non-Hispanic white, non-Hispanic black, and Hispanic 

adults. As expected, prevalence of past or current HBV infection was greater among non-Hispanic 

Asian adults born outside the United States (26.5%) than among those born in the United States 

(2.7%). Prevalence among Asian adults born in the United States was similar to the prevalence in 

some of the other race and Hispanic origin groups, although some differences still existed. These 

results are expected based on prior literature on HBV infection in Asian countries and among 

Asian persons living in the United States (1,3).

Estimates of current HCV infection vary among Asian countries, from 0.1%–4.4% (4). Although 

NHANES oversamples non-Hispanic Asian persons, the Asian sample is still very small to 

estimate conditions with low prevalence, such as HCV infection (less than 1% in the total 

population and less than 2% for any specific race and Hispanic origin subgroup).

NHANES does not include groups that may be considered at higher risk of hepatitis infection 

(e.g., institutionalized, incarcerated, injection drug-using, and homeless populations, and those 

living in nonhospital-based long-term care facilities). Therefore, these data provide conservative 

estimates of disease prevalence.

Worldwide, a majority of diagnoses of cirrhosis and hepatocellular carcinoma have been 

attributed to viral hepatitis infection, especially HBV and HCV infection (5). Therefore, it is 

important to continue to monitor the prevalence of these serious infections among racial and 

ethnic groups in the United States.

Definitions

Prevalence of antibody to HAV: Reflects immunity due to vaccination or natural infection. HAV 

infection is primarily transmitted by close personal contact or ingestion of contaminated food or 

drink.

Prevalence of past or current HBV infection: Presence of hepatitis B core antibody is a measure 

of past or current infection and not a measure of immunity due to vaccination. HBV infection is 

transmitted primarily through sexual contact, contaminated blood, or from an infected mother to 

her newborn.

Prevalence of current HBV infection: Presence of hepatitis B surface antigen is indicative of 

current active or acute infection.
NCHS Data Brief ■ No. 225 ■ November 2015

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Prevalence of current HCV infection: Presence of hepatitis C virus RNA is a measure of current 

or active infection. HCV infection is transmitted primarily by injection drug use or receipt of 

contaminated blood.

Data source and methods

Data from NHANES 2011–2014 were used for these analyses. NHANES is a cross-sectional 

survey designed to monitor the health and nutritional status of the civilian, noninstitutionalized 

U.S. population. The survey consists of interviews conducted in participants’ homes followed 

by standardized physical examinations that include collection of blood and other biological 

specimens for laboratory tests.

NHANES is based on a complex, multistage design with data released in 2-year cycles. The 

design includes oversampling and the ability to combine cycles to obtain reliable estimates for 

population subgroups. Starting with the 2011–2012 survey cycle, non-Hispanic Asian persons 

were oversampled to obtain more reliable estimates of health for this race and ethnic group. 

Additional information about NHANES is available from: http://www.cdc.gov/nchs/nhanes.htm.

Prevalence estimates and standard errors were calculated in SAS-callable SUDAAN software, 

release 11.0 (RTI International, Research Triangle Park, N.C.). The examination sample weights 

were used to account for differing probabilities of selection, nonresponse, and noncoverage. 

Taylor series linearization was used to calculate standard errors to take into account the complex 

sampling design. Differences between groups were evaluated using a Student’s t statistic at the 

p less than 0.05 significance level. Estimates with a relative standard error greater than 30% 

or based on fewer than 10 positives were designated as potentially unreliable and should be 

interpreted with caution. All differences discussed are statistically significant unless otherwise 

indicated. Calculated estimates were not age-adjusted and no adjustments were made for multiple 

comparisons.
NCHS Data Brief ■ No. 225 ■ November 2015

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About the authors

Deanna Kruszon-Moran, Ryne Paulose-Ram, and Geraldine McQuillan are with CDC’s 

National Center for Health Statistics, Division of Health and Nutrition Examination Surveys. 

Maxine Denniston is with CDC’s National Center for HIV/AIDS, Viral Hepatitis, STD and TB 

Prevention, Division of Viral Hepatitis.

References

1. CDC, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention. Chapter 3: 

Viral hepatitis. In: Epidemiologic Profile 2010: Asians and Native Hawaiians and Other Pacific 

Islanders. Atlanta, GA: 26–37. 2012.

2. WHO. Hepatitis A. 2007. Available from: http://www.who.int/csr/disease/hepatitis/

HepatitisA_whocdscsredc2000_7.pdf.

3. CDC. Viral hepatitis–CDC recommendations for specific populations and settings. Available 

from: http://www.cdc.gov/hepatitis/Populations/api.htm.

4. Nguyen LH, Nguyen MH. Systematic review: Asian patients with chronic hepatitis C 

infection. Aliment Pharmacol Ther 37(10):921–36. 2013.

5. Perz JF, Armstrong GL, Farrington LA, Hutin YJ, Bell BP. The contributions of hepatitis B 

virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol 

45(4):529–38. 2006.
NCHS Data Brief ■ No. 225 ■ November 2015

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Suggested citation

Kruszon-Moran D, Paulose-Ram R, 

Denniston M, McQuillan G. Viral hepatitis 

among non-Hispanic Asian adults in the 

United States, 2011–2014. NCHS data brief, 

no 225. Hyattsville, MD: National Center 

for Health Statistics. 2015.

Copyright information

All material appearing in this report is in 

the public domain and may be reproduced 

or copied without permission; citation as to 

source, however, is appreciated.

National Center for Health 

Statistics

Charles J. Rothwell, M.S., M.B.A., Director

Nathaniel Schenker, Ph.D., Deputy Director

Jennifer H. Madans, Ph.D., Associate 

Director for Science

Division of Health and Nutrition 

Examination Surveys

Kathryn S. Porter, M.D., M.S., Director

Ryne Paulose-Ram, Ph.D., Associate 

Director for Science

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