Exhibit 10.22

EMPLOYMENT AGREEMENT

THIS EMPLOYMENT AGREEMENT(this "Agreement") is made and entered into effective as of this
4th day of February 2004 (the "Effective Date"), by and betweenCYPRESS BIOSCIENCE, INC.,
a Delaware corporation (the "Company") and Denise Woolard (the "Employee").

WHEREAS, the Company desires to employ the Employee in an executive capacity as Vice President of Business and Legal Affairs and Secretary
on the terms and conditions set forth herein and the Employee is willing to accept and undertake such employment.

AGREEMENT

NOW THEREFORE, in consideration of the premises and the mutual covenants herein set forth, the Company and the
Employee agree as follows:

ARTICLE 1

EMPLOYMENT; TERM; DUTIES

1.1    Employment.Upon the terms and conditions hereinafter set forth, the Company hereby employs the Employee,
and the Employee hereby accepts continued employment, as Vice President of Business and Legal Affairs and Secretary ("Vice President") of the Company.

1.2    Term.Unless sooner terminated as provided in Article 5 hereof, the Employee's employment hereunder
shall be for a term commencing on the Effective Date and ending on February 4, 2006, subject to automatic renewal for one year periods following February 4, 2006, unless written notice
has been provided by either party at least 75 days prior to the date of such automatic renewal (a"Non-Renewal Notice").
Notwithstanding anything herein to the contrary, either party may terminate the Employee's employment under this Agreement at any time, with or without Cause, subject to the terms and conditions of
Article 5 herein. The actual term of employment hereunder, giving effect to any early termination of employment under Article 5 hereof, is referred to as the "Term."

1.3    Duties.During the Term, the Employee shall perform such executive duties for the Company and for its
subsidiaries, consistent with her position hereunder and as typically associated with the duties of a Vice President of a publicly-held corporation and as reasonably may be assigned to her
from time to time by the Board and the Chief Executive Officer of the Company. Except as contemplated by Section 1.5, the Employee shall devote her entire business time, attention and energies
to the performance of her duties hereunder.

1.4    Exclusive Agreement.The Employee represents and warrants to the Company that she is not a party to any
agreement or arrangement, whether written or oral, in effect which would prevent the Employee from rendering the services contemplated hereunder to the Company during the Term.

1.5    Other Activity.Notwithstanding the foregoing, subject to her fiduciary duties to the Company under
applicable law, the Company acknowledges and understands that the Employee may serve as a director of other companies not in competition with the Company by providing prior written notice to the
Company; provided, however,that the performance of such services shall not restrict or limit in any manner the Employee's ability to perform her duties
hereunder.

1.6    Insurance.The Company shall obtain, and shall use its commercially reasonable best efforts to maintain
during the Term, Director's and Officer's Insurance and Product Liability Insurance

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policies,
with full defense coverage of at least $10,000,000 for each, respectively, with regard to all actions undertaken by the Employee in her capacity as an officer and employee of the Company.

ARTICLE 2

COMPENSATION

2.1    Base Salary.For all services rendered by the Employee hereunder and in consideration of all covenants and
conditions undertaken by her pursuant to this Agreement, the Company shall pay the Employee an annual base salary ("Base Salary") of $225,000 per year
in equal semi-monthly installments, and which shall be increased if there is an across the board increase in base salary for other executive officers. In addition, each year during the
Term, the Board shall review the Base Salary with a view to determining whether it would be appropriate to increase such Base Salary. The annual Base Salary payable to the Employee hereunder, as it
may be so increased, thereafter shall constitute the"Base Salary". If the first or last month of the Term is not a full calendar month, then any
calculation of Base Salary for such period shall be prorated for the number of days in such months during which the Employee was employed.

2.2    Bonuses.

(a)In addition to the Base Salary, for the year 2004, the Employee shall be paid a minimum cash bonus equal to 25% of
Employee's Base Salary on the date such bonus is payable, which shall be within 45 days of December 31, 2004, payable in a lump sum ("Minimum
Bonus"). This Minimum Bonus shall be the minimum amount payable to the Employee for services provided in 2004.

(b)In addition to the Base Salary, the Employee may be eligible for cash bonuses (the"Bonus
Amount") based on the performance of the Employee during a fiscal year, as evaluated by the CEO and the Board in their sole discretion. It is acknowledged and agreed that the
determination and the payment of the Bonus Amount to the Employee shall be at the sole discretion of the Board which may consider, among other matters, the financial condition of the Company at the
time. In exercising its discretion pursuant to this subsection, the Board shall act in a manner at least as favorable to the Employee as governs the award of bonuses to other executive officers and
key employees of the Company.

2.3    Deductions.The Company shall deduct from the compensation described in this Section 2 any Federal,
state or city withholding taxes, social security contributions and any other amounts which may be required to be deducted or withheld by the Company pursuant to any federal, state or city laws, rules
or regulations.

ARTICLE 3

BENEFITS

3.1    Benefits.During the Term, the Employee shall be entitled to participate in such compensation and incentive
plans and group life, health, accident, disability and hospitalization insurance plans, pension plans and retirements plans as the Company may make available to its other executive officers.

3.2    Life Insurance.The Company agrees that it will provide the Employee with life insurance policy or policies
in amounts at least as favorable to the Employee as governs the other executive officers, subject to availability of such insurance at commercially reasonable costs and the mutual agreement of the
Company and the Employee as to the type and nature of the policies.

3.3    Expenses.The Company agrees that the Employee is authorized to incur reasonable and customary expenses in
the performance of her duties hereunder, including travel and entertainment costs, and upon presentation of appropriate documentation thereof, the Company promptly shall pay or

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reimburse
the Employee for such reasonable expenses. In the event that any reimbursement by the Company of expenses of the Employee hereunder is deducted by the Company, and results in additional
taxes due and payable by the Employee, the Company shall pay to the Employee an additional sum equal to the amount of such additional tax liability of the Employee.

3.4    Vacations.During each full year of the Term, the Employee shall be entitled to four (4) weeks of
paid vacation, to be taken at times determined by the Employee which are mutually agreeable with the Company and which do not unreasonably interfere with the performance of her duties hereunder.

ARTICLE 4

STOCK OPTIONS

4.1    Stock Options.

(a)Upon the date this Agreement is signed by both parties, and pursuant to the terms of the Company's 2000 Equity Incentive
Plan (the"Plan"), the Employee will be granted a stock option to purchase 100,000 shares of the Company's common stock (the "Option"). The
Option will be governed by and granted pursuant to a separate stock option agreement and the Plan. The exercise price per share of the
Option will be equal to the fair market value of the common stock of the Company on the date of grant, as required by, and consistent with the Plan. The Option will be subject to vesting ratably and
daily over four years so long as the Employee provides Continuous Service (as such term is defined in the Plan) to the Company. For purposes of this Agreement, the Option and all other stock options
or stock awards granted to the Employee during the Term shall be referred to as the"Options".

(b)In the event of a termination (as described in Article 5), and except as otherwise provided in
Section 4.1(c) and 4.1(d) hereof, all Options which have not vested as of the Termination Date shall cease vesting and shall be cancelled as of the Termination Date. All vested Options shall be
cancelled 90 days after the Termination Date.

(c)Upon the Employee's death or Disability (as defined in Section 5.1 below), all rights under such Options shall
transfer to the Employee's designated beneficiary. All Options shall be cancelled 90 days after the Employee is terminated due to Disability. In the event of the Employee's death, the
Employee's legal representatives shall have 180 days following the Termination Date to exercise the Options before they are cancelled.

(d)The Company may grant the Employee options to purchase the Company's common stock in addition to the Options at such
times and on such terms as may be decided from time to time by the Board, in its sole discretion.

ARTICLE 5

DEATH, DISABILITY; TERMINATION

5.1    Death; Disability.The Employee's employment hereunder shall terminate upon her death or, at the election of
the Company, by written notice to the Employee if the Employee becomes Disabled (as such term is hereinafter defined). In the event of a termination of the Employee's employment for death or
disability, the Company shall pay the Employee (or her legal representatives, as the case may be) all earned and unpaid wages and accrued vacation.

For
the purposes of this Agreement, the Employee shall be deemed to be"Disabled"or have a "Disability"if as a result of the occurrence of
mental or physical disability during the Term she has been unable to perform her duties hereunder for
six consecutive months or 180 days in any 12 consecutive month period, as determined in good faith by the Board; provided, however,that if the
Employee develops a mental or physical disability during the Term, and it is determined, in the

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reasonable
professional judgment of an independent, objective and qualified medical expert in the field of such disability, that the Employee will be unable to perform her duties hereunder and that
such disability will continue for six consecutive months or 180 days in any twelve (12) consecutive month period, then the Company shall be permitted to terminate the Employee's
employment immediately.

The
date of any termination of employment under this Section 5.1 or Sections 5.2, 5.3, 5.4 or 5.5 is referred to herein as the"Termination
Date."

5.2    Termination of Employment by Employee.

(a)Notwithstanding any provision to the contrary herein, unless otherwise provided herein or unless otherwise provided by
law, the Employee at any time, upon 30 days' written notice to the Company, may terminate her employment by the Company hereunder. Except as otherwise provided in Section 5.2(b) below,
the Company shall not be liable to the Employee for the payment of any amount on such termination.

(b)In the event that the Employee terminates her employment as Vice President following (i) an uncured material
breach of this Agreement by the Company, (ii) the occurrence the relocation of the Company's executive offices or principal business location to a point more than 30 miles from the San Diego,
California area, (iii) any uncured action by the Board or direction given by the Board to the Employee that is contrary to applicable law or accounting standards or constitutes an unethical
business practice, or (iv) a demotion or the occurrence of a material reduction in the Employee's authority, functions or responsibilities as Vice President without her consent, then such
termination by the Employee shall be deemed for all purposes, including for purposes of severance payments and benefits provided under Section 5.4 hereof, to be a termination by the Company of
the employment of the Employee hereunder without cause pursuant to Section 5.4. The Company shall have 30 days following receipt of written notice by the Employee to the Company of the
material breach described in items (i) and (iii) above, setting forth in reasonable detail the matter constituting such breach, to cure such breach.

5.3    Termination of Employment With Cause.In addition to any other remedies available to it at law, in equity or
as set forth in this Agreement, the Company shall have the right, upon written notice to the Employee, to immediately terminate her employment hereunder if the Employee (a) evidences a pattern
of willful breach in any material respect of any material provision of this Agreement or a pattern of willful violation of any reasonable policies or orders of the CEO or the Board and such pattern of
willful breach or violation does not cease within 30 days after the Employee's receipt of written notice thereof from the Board setting forth in reasonable detail the matters constituting such
pattern,, (b) the Employee's commission of an act that materially injures the business of the Company; (c) the Employee's conviction of a felony involving moral turpitude that is likely
to inflict or has inflicted material injury on the business of the Company, (d) the Employee's engaging or in any manner participating in any activity which is directly competitive with or
injurious to the Company or any of its Affiliates or which violates any material provisions of Article 6 hereof or the Employee's Proprietary Information and Inventions Agreement with the
Company; or (e) the Employee's commission of any fraud against the Company, its Affiliates, employees, agents or customers or use or intentional appropriation for his personal use or benefit of
any funds or properties of the Company not authorized by the CEO or the Board to be so used or appropriated.

5.4    Termination of Employment Without Cause or for Non-Renewal.

(a)Notwithstanding any provision to the contrary herein and unless otherwise provided by law, the Company, at any time upon
30 days' written notice to the Employee, in its sole and absolute discretion and for any or no reason, may terminate the employment of the Employee as Vice President hereunder without cause. In
such event, if the Company issues the Employee a Non-renewal Notice, or if the Agreement expires and the Employee is not rehired, then upon the Employee furnishing the Company with a
Release and Waiver of Claims in a form acceptable to the Company, the Company

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shall
pay the Employee an amount equal to the following: (a) if such event occurs within 12 months following the Effective Date, a lump sum equal to twelve months of the Base Salary,
(b) if such event occurs after 12 months following the Effective Date and within 26 months following the Effective Date, a lump sum equal to nine months of the Base Salary and
(c) if such event occurs after 26 months following the Effective Date, a lump sum equal to six months of the Base Salary, subject to Section 5.5 if the termination occurs in
connection with a Change in Control.

(b)In the event that the employment of the Employee hereunder is terminated by the Company without cause, a portion of all
unvested Options shall vest immediately upon the Termination Date as follows: (a) if such event occurs within 12 months following the Effective Date, the unvested Options that would have
vested in the 12 month period following such Termination Date, (b) if such event occurs after 12 months following the Effective Date and within 26 months following the
Effective Date, the unvested Options that would have vested in the nine month period following such Termination Date and (c) if such event occurs after 26 months following the Effective
Date, the unvested Options that would have vested in the 6 month period following such Termination Date.

(c)In the event that the employment of the Employee hereunder is terminated by the Company without cause, the Company, at no
cost to the Employee and for a period of 12 months from the Termination Date, shallcontinue to provide Employee and her family with all health insurance benefits under COBRA; provided that
Employee elects and is eligible for continued coverage under COBRA.

(d)The Employee acknowledges that the payments referred to in Section 5.2 and this Section 5.4 constitute the
only payments which the Employee shall be entitled to receive from the Company under this Agreement in the event of any termination pursuant to Section 5.2, 5.3 and this Section 5.4, and
that except for such payments and such other obligations as are expressly provided herein the Company shall have no further liability or obligation to her under this Agreement.

(e)The Employee shall have no duty to mitigate damages in order to receive any severance payments and benefits provided in
this Section 5.4.

5.5    Change in Control.

(a)In the event Employee is terminated without cause during the period beginning one month before and ending
13 months following the effective date of a Change in Control, the Employee shall be paid a lump sum equal to 12 months of Base Salary and all Options shall immediately vest as provided
in Section 5.4(b) and shall receive the benefits described in Section 5.4(b).

(b)For purposes of this Agreement, Change in Control means: (i) a sale of all or substantially all of the assets of
the Company; (ii) a merger or consolidation in which the Company is not the surviving entity and in which the holders of the Company's outstanding voting stock immediately prior to such
transaction own, immediately after such transaction, securities representing less than 50% of the voting power of the entity surviving such transaction or, where the surviving entity is a wholly-owned
subsidiary of another entity, the surviving entity's parent; (iii) a reverse merger in which the Company is the surviving entity but the shares of Common Stock outstanding immediately preceding
the merger are converted by virtue of the merger into other property, whether in the form of securities of the surviving entity's parent, cash or otherwise, and in which the holders of the Company's
outstanding voting stock immediately prior to such transaction own, immediately after such transaction, securities representing less than 50% of the voting power of the Company or, where the Company
is a wholly-owned subsidiary of another entity, the Company's parent; or (iv) an acquisition by any person, entity or group within the meaning of Section 13(d) or 14(d) of the Exchange
Act of 1934, as amended (the"Exchange Act"), or any comparable successor provisions (excluding any employee benefit plan, or related trust, sponsored
or maintained by the Company or subsidiary of the Company or other entity controlled by the Company) of the beneficial ownership (within the meaning of Rule 13d-3 promulgated under
the Exchange Act, or comparable successor rule) of securities of the Company

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representing
at least 75% of the combined voting power entitled to vote in the election of directors of the Company;provided, however,that nothing in
this paragraph shall apply to a sale of assets, merger or other transaction effected exclusively for the purpose of changing the domicile of the Company.

ARTICLE 6

INVENTIONS, NON-DISCLOSURE

6.1    Non-Disclosure and Inventions.As a condition of employment the Employee agrees to execute and
abide by the Company's Proprietary Information and Inventions Agreement attached hereto as Exhibit A.

6.2    Return of Company Property.Promptly upon the expiration or termination of the Employee's employment
hereunder for any reason, the Employee shall surrender to the Company all documents, drawings, work papers, lists, memoranda, records and other data (including all copies) constituting or disclosing
any of the foregoing information.

6.3    Breach of Non-Disclosure Provision.In the event that the Employee shall breach
Section 6.2 hereof or any provision of the Proprietary Information and Inventions Agreement, or in the event that any such breach is threatened by the Employee, in addition to and without
limiting or waiving any other remedies available to the Company at law or in equity, the Company shall be entitled to immediate injunctive relief in any court having the capacity to grant such relief,
to restrain any such breach or threatened breach and to enforce the provisions of Section 6. The Employee acknowledges and agrees that there is no adequate remedy at law for any such breach or
threatened breach and, in the event that any action or proceeding is brought seeking injunctive relief, the Employee shall not use as a defense thereto that there is an adequate remedy at law.

6.4    Reasonable Restrictions.The parties acknowledge that (a) the agreements in this Article 6 are
essential to protect the business and goodwill of the Company, and (b) the foregoing restrictions are under all of the circumstances reasonable and necessary for the protection of the Company
and its business.

ARTICLE 7

ARBITRATION

To ensure the rapid and economical resolution of disputes that may arise in connection with the Employee's employment with the Company, the Employee and the
Company agree that any and all disputes, claims, or causes of action, in law or equity, arising from or relating to the enforcement, breach, performance, or interpretation of this Agreement, the
Employee's employment, or the termination of such employment, shall be resolved, to the fullest extent permitted by law, by final, binding and confidential arbitration in San Diego, California
conducted by the Judicial Arbitration and Mediation Services, Inc. ("JAMS") or its successor, under the then applicable rules of JAMS. The Employee acknowledges that
by agreeing to this arbitration procedure, both the Employee and the Company waive the right to resolve any such dispute through a trial by jury
or judge or administrative proceeding. The arbitrator shall: (a) have the authority to compel adequate discovery for the resolution of the dispute and to award such
relief as would otherwise be permitted by law; and (b) issue a written arbitration decision including the arbitrator's essential findings and conclusions and a statement of the award. The
arbitrator shall be authorized to award any or all remedies that the Employee or the Company would be entitled to seek in a court of law. The Company shall pay all JAMS' arbitration fees in excess of
those which would be required if the dispute were decided in a court of law. Nothing in this Agreement is intended to prevent either the Employee or the Company from obtaining injunctive relief in
court to prevent irreparable harm pending the conclusion of any such arbitration.

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ARTICLE 8

MISCELLANEOUS

8.1    Binding Effect.This Agreement shall be binding upon and inure to the benefit of the parties hereto and
their respective legal representatives, heirs, distributes and successors; provided, that the obligations of the Employee under this Agreement shall not be delegable by her.

8.2    Notices.All notices and other communications hereunder and all legal process in regard hereto shall be
validly given, made or served if in writing, when delivered personally (by courier service or otherwise), or when actually received when mailed by first-class certified or registered United States
mail, postage-prepaid and return receipt requested, to the address of the party to receive such notice or
other communication set forth below, or at such other address as any party hereto may from time to time advise the other party in writing:

If
to the Company:



If
to the Employee:



8.3    Severability.If any provision of this Agreement, or portion thereof, shall be held invalid or unenforceable
by a court of competent jurisdiction, such invalidity or unenforceability shall attach only to such provision or portion thereof, and shall not in any manner affect or render invalid or unenforceable
any other provision of this Agreement or portion thereof, and this Agreement shall be carried out as if any such invalid or unenforceable provision or portion thereof were not contained herein. In
addition, any such invalid or unenforceable provision or portion thereof shall be deemed, without further action on the part of the parties hereto, modified, amended or limited to the extent necessary
to render the same valid and enforceable.

8.4    Waiver.No waiver by a party hereto of a breach or default hereunder by the other party shall be considered
valid, unless in writing signed by such first party, and no such waiver shall be deemed a waiver of any subsequent breach or default of the same or any other nature.

8.5    Entire Agreement.This Agreement sets forth the entire agreement between the parties with respect to the
subject matter hereof, and supersedes any and all prior agreements between the Company and the Employee, whether written or oral, relating to any or all matters covered by and contained or otherwise
dealt with in this Agreement. No representation, warranty, undertaking or covenant is made by either party hereto except as provided herein and any representations, warranties undertakings or
covenants not set forth herein are specifically disclaimed. This Agreement does not constitute a commitment of the Company with regard to the Employee's employment, express or implied, other than to
the extent expressly provided for herein.

8.6    Amendment.No modification, change or amendment of this Agreement or any of its provisions shall be valid,
unless in writing and signed by the party against whom such claimed modification, change or amendment is sought to be enforced.

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8.7    Authority.The parties each represent and warrant that they have the power, authority and right to enter
into this Agreement and to carry out and perform the terms, covenants and conditions hereof.

8.8    Titles.The titles of the Articles and Sections of this Agreement are inserted merely for convenience and
ease of reference and shall not affect or modify the meaning of any of the terms, covenants or conditions of this Agreement.

8.9    Applicable Law.This Agreement, and all of the rights and obligations of the parties in connection with the
employment relationship established hereby, shall be governed by and construed in accordance with the internal laws of the State of California without giving effect to principals relating to the
conflicts of law.

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year first above written.

|                                |  | CYPRESS BIOSCIENCE, INC.
|------------------------------- |  | ------------------------
|                                |  | By:                     
|                                |  | Its:                    
|/s/DENISE WOOLARDDenise Woolard |  |                         

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