Exhibit 10.10

January 28, 2005

 Clinical Data Sales & Service, Inc.2 Thurber Boulevard Smithfield, Rhode Island 02917

Re:     Sixth Amendment
Gentlemen:

Clinical Data Sales & Service, Inc., a Delaware corporation (“Borrower”)and LaSalle Business Credit, LLC, a Delaware limited liability company,(“Lender”) have entered into that certain Loan and Security Agreement datedMarch 31, 2003 (the "Security Agreement").  From time to time thereafter,Borrowers and Lender may have executed various amendments (each an "Amendment"and collectively the "Amendments") to the Security Agreement (the SecurityAgreement and the Amendments hereinafter are referred to, collectively, as the"Agreement").   Borrowers and Lender now desire to further amend theAgreement as provided herein, subject to the terms and conditions hereinafter set forth.

NOW, THEREFORE, in consideration of the foregoing recitals, the mutual covenants andagreements set forth herein and other good and valuable consideration, the receipt andsufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows:

1.     The Agreement hereby is amended as follows:

(a)     Subparagraph (4)(c)(v) of the Agreement is deleted in itsentirety and the following is substituted in its place:

(v)      Transaction Fee: Borrower shall pay to Lender atransaction fee of Five Hundred and No/100 Dollars ($500.00) with respect to internalcosts and expenses (in addition to any reimbursable out-of-pocket costs and expenses ofLender, which fee shall be fully earned and payable on the date of this Amendment.

(b)      Subparagraph 13(e) of the Agreement is deleted in itsentirety and the following is substituted in its place:

(e)      Dividends and Distributions.

No Borrower shall declare or pay any dividend or other distribution (whether in cash orin kind) on any class of its stock (if such Borrower is a corporation) or on account ofany equity interest in such Borrower (if such Borrower is a partnership, limited liabilitycompany or other type of entity). Notwithstanding the foregoing, and provided that (i)each such dividend payment is permitted under all applicable laws and (ii) no Event ofDefault shall have occurred prior to, or would occur as a result of, any such dividendpayment, (w) each Borrower may declare and pay to such Borrower’s Parent suchdividends as are necessary to reimburse Parent for all expenses incurred on behalf of suchBorrower and (x) Borrowers may declare and pay to Borrower’s Parent dividends in anamount sufficient for Parent to pay quarterly dividends of $0.03 per share so long as (y)the amount of such dividends so declared and paid shall not, in any case, exceed SixHundred Thousand and No/100 Dollars ($600,000.00) in the aggregate in any Fiscal Year and(z) after giving effect to such payment, Borrowers shall have Excess Availability of atleast $1,000,000.00.

2.      This Amendment shall not become effective until fullyexecuted by all parties hereto.

3.      Except as expressly amended hereby and by any othersupplemental documents or instruments executed by either party hereto in order toeffectuate the transactions contemplated hereby, the Agreement thereto hereby is ratifiedand confirmed by the parties hereto and remain in full force and effect in accordance withthe terms thereof.

LASALLE BUSINESS CREDIT, LLCBy_______________________________ 

Title______________________________

ACKNOWLEDGED AND AGREED TO this 7th day of February, 2005:

CLINICAL DATA SALES & SERVICE, INC.

By__________________________ 

Title _______________________