Exhibit 10.20
 SECOND AMENDMENT TO LEASE
 Second Amendment ARE-SD REGION NO. 20, LLC Landlord CYPRESS BIOSCIENCE, INC. Tenant
 RECITALS
 A. Lease Premises
 B.
 C.
 NOW, THEREFORE,
 1.
    
    Base Term. The defined term Base Term on page 1 of the Lease is hereby deleted in
its entirety and replaced with the following:
 Base Term:
 2.
    
    Base Rent. Tenant shall continue to pay Base Rent as provided for in the Lease
through December 31, 2009. Commencing on January 1, 2010, Tenant shall pay Base Rent in the
amount of $6,383.00 per month through the expiration of the Base Term.3.
    
    Brokers. Landlord and Tenant each represents and warrants that it has not,
with the exception of BRE Commercial, Inc., dealt with any broker, agent or other person
(collectively, Broker) in connection with the transaction reflected in this Second Amendment
and that no Broker, other than BRE Commercial, Inc., brought about this transaction, other
than BRE Commercial, Inc. (dba Grubb & Ellis/BRE Commercial). Landlord and Tenant each hereby
agree to indemnify and hold the other harmless from and against any claims by any Broker,
other than the broker, if any named in this Second Amendment, claiming a commission or other
form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with
regard to this leasing transaction.4.
    
    Miscellaneous.
 a.       This Second Amendment is the entire agreement between the parties with respect to the
subject matter hereof and supersedes all prior and contemporaneous oral and written
agreements and discussions. This Second Amendment may be amended only by an agreement in
writing, signed by the parties hereto.
 (ALEXANDRIA LOGO)
 1




---



##### 



b.       This Second Amendment is binding upon and shall inure to the benefit of the parties
hereto, their respective agents, employees, representatives, officers, directors,
divisions, subsidiaries, affiliates, assigns, heirs, successors in interest and
shareholders.c.       This Second Amendment may be executed in any number of counterparts, each of which
shall be deemed an original, but all of which when taken together shall constitute one and
the same instrument. The signature page of any counterpart may be detached therefrom
without impairing the legal effect of the signature(s) thereon provided such signature
page is attached to any other counterpart identical thereto except having additional
signature pages executed by other parties to this Second Amendment attached thereto.d.       Except as amended and/or modified by this Second Amendment, the Lease is hereby
ratified and confirmed and all other terms of the Lease shall remain in full force and
effect, unaltered and unchanged by this Second Amendment. In the event of any conflict
between the provisions of this Second Amendment and the provisions of the Lease, the
provisions of this Second Amendment shall prevail.
 [Signatures are on the next page.]
 (ALEXANDRIA LOGO)
 2




---



##### 



IN WITNESS WHEREOF
 LANDLORD:
    ARE-SD REGION NO. 20, LLC,
a Delaware limited liability companyBy:
    ARE-SD REGION NO. 20 MEMBER, LLC,a Delaware limited liability company,as Managing Member By:
    ALEXANDRIA REAL ESTATE EQUITIES, L.P.,a Delaware limited partnership, as Managing Member By:
    ARE-QRS CORP.,a Maryland corporation,as General Partner By:
    /s/ Gary DeanIts:        VP- Legal Affairs TENANT:
    CYPRESS BIOSCIENCE, INC.,
a Delaware corporationBy:
    /s/ Sabrina JohnsonIts:                     CFO/COO (ALEXANDRIA LOGO)