EXHIBIT 10.4
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                 WAIVER AND SECOND AMENDMENT TO CREDIT AGREEMENT

     THIS WAIVER AND SECOND AMENDMENT TO CREDIT AGREEMENT (this "Amendment")
dated as of February 25, 2005 to the Credit Agreement, dated as of February 26,
2004, as amended by a First Amendment to Credit Agreement dated as of December
22, 2004 (collectively the "Credit Agreement") by and among CHATTEM, INC. (the
"Borrower"), SIGNAL INVESTMENT & MANAGEMENT CO., SUNDEX, LLC AND CHATTEM
(CANADA) HOLDINGS, INC. (individually, a "Guarantor" and collectively, the
"Guarantors") the several bank parties to the Credit Agreement (the "Lenders"),
and BANK OF AMERICA, N.A., as the Agent (in such capacity, the "Agent") for all
the Lenders party to the Credit Agreement.


                                R E C I T A L S:

     WHEREAS, the Agent, the Lenders, the Borrower and the Guarantors are
parties to the Credit Agreement;

     WHEREAS, the Borrower and the Guarantors have requested certain amendments
to the Credit Agreement and a waiver of certain provisions of the Credit
Agreement as set forth herein.

     NOW, THEREFORE, in consideration of the premises set forth above, the terms
and conditions contained herein, and other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties hereto
agree as follows:

     1.   DEFINITIONS. Unless otherwise defined herein, capitalized terms that
are defined in the Credit Agreement are used herein as therein defined.

     2.   WAIVER. Subject to the complete satisfaction of all of the conditions
set forth in Section 4 below and subject to the other terms herein, the Agent
and the Lenders for the period beginning on February 26, 2004 and ending on the
Effective Date (as defined below) hereby waive any Default or Event of Default
which has occurred or which now exists as a result of the failure of Borrower
and the Guarantors to be in compliance with Section 8.6, Advances, Investments
and Loans of the Credit Agreement because a Subsidiary of the Borrower, HBA
Indemnity Company, Ltd., owns securities in the amount of $1,210,000 issued or
guaranteed by the United States of America or an agency or instrumentality
thereof with maturities of more than twelve months from the date of acquisition.
The foregoing waiver is limited to the matters set forth in this Section 2 and
no provision of this Section 2 shall be deemed in any way to constitute a waiver
of (except as otherwise set forth in this Section 2) (i) any Default or any
Event of Default, (ii) any condition precedent, (iii) any other term or
provision of the Credit Agreement or the other Credit Documents, or (iv) any
right, power or remedy available to Agent or any Lender. The Agent and each
Lender reserve all of their rights, powers and remedies under law, the Credit
Agreement and all other Credit Documents.
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     3.   AMENDMENTS. Subject to the complete satisfaction of all of the
conditions set forth in Section 4 below and subject to the other terms herein:

     3.1  Subpart (a) of the definition of "Cash Equivalents" in Subsection 1.1
of the Credit Agreement is amended and restated in its entirety as follows:

          (a) securities issued or directly and fully guaranteed or insured by
          the United States of America or any agency or instrumentality thereof
          (provided that the full faith and credit of the United States of
          America is pledged in support thereof) having maturities of not more
          than twelve-months from the date of acquisition, provided that solely
          with respect to HBA Indemnity Company, Ltd ("HBA") such securities of
          a type described in this subpart (a) owned by HBA may have maturities
          of not more than twenty-four months from the date of acquisition,"

     4.   CONDITIONS. This Amendment shall become effective upon the date (the
"Effective Date") when the Agent shall have received (i) counterparts of this
Agreement duly executed and delivered by the Borrower, each Guarantor and each
Lender (ii) each other document or instrument required to be delivered hereunder
and (iii) the Borrower shall have paid to the Agent, all reasonable costs and
expenses of the Agent in connection with the preparation, execution and delivery
of this Amendment, including without limitation the reasonable fees and expenses
of the Agent's legal counsel.

     5.   REPRESENTATIONS, WARRANTIES AND AGREEMENTS. Each Credit Party hereby
represents and warrants to, and agrees with, the Agent and the Lenders that:

     5.1  No Default or Event of Default shall have occurred and be continuing
on the Effective Date or after giving effect to the transactions contemplated
herein.

     5.2  Each of the representations and warranties made by the Credit Parties
in or pursuant to the Credit Documents shall be true and correct in all material
respects on and as of the Effective Date (after giving effect hereto) as if made
on and as of such date, except to the extent such representations and warranties
expressly relate to a particular date, in which case such representations and
warranties were true and correct in all material respects as of such date.

     5.3  Each Credit Party has the requisite corporate power and authority to
execute, deliver and perform this Amendment.

     5.4  Each of the Credit Parties hereby consents to this Amendment and
further hereby reaffirm, ratify and confirm all covenants, representations and
warranties made in the Credit Agreement, and all other Credit Documents to which
it is a party (after giving effect hereto), all of which continues in full force
and effect. Without limitation of the foregoing, each Credit Party hereby
grants, and reaffirms the grant, of a security interest by such Obligor in favor
of the Agent in the Collateral under the Collateral Documents.

     6.   REFERENCE TO AGREEMENTS.

     6.1  On and after the Effective Date, (a) each reference in the Credit
Agreement, respectively, to "this Agreement," "hereunder," "hereof," "herein,"
or words of like import shall mean and be a reference to the Credit Agreement,
as amended hereby, and (b) each

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reference to the Credit Agreement in all other Credit Documents shall mean and
be a reference to the Credit Agreement, as amended hereby.

     6.2  Except as otherwise provided herein, all Credit Documents, and all
other documents, instruments and agreements executed and/or delivered in
connection therewith, shall remain in full force and effect, and are hereby
ratified and confirmed.

     6.3  Except as specifically stated herein, the execution, delivery and
effectiveness of this Agreement shall not operate as an amendment to any
provision of the Credit Agreement, nor a waiver of, or consent to any departure
from, any right, power or remedy of Agent or any Lender, nor constitute a waiver
of, or consent to any departure from, any provision of the Credit Agreement or
any of the other Credit Documents.

     6.4  This Agreement shall be deemed a Credit Document for the purposes of
the Credit Agreement.

     7.   GOVERNING LAW. This Agreement shall be governed by and construed in
accordance with the internal laws of the State of Tennessee.

     8.   HEADINGS. Section headings in this Agreement are included herein for
convenience of reference only and shall not constitute a part of this Agreement
for any other purpose.

     9.   COUNTERPARTS. This Agreement may be executed by one or more of the
parties to this Agreement on any number of separate counterparts and all of said
counterparts taken together shall be deemed to constitute one and the same
instrument. Delivery by any party of telecopied copies of executed counterparts
hereof shall constitute execution and delivery hereof by such party.





                            [SIGNATURE PAGES FOLLOW]

















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     IN WITNESS WHEREOF, this Waiver and Second Amendment has been duly executed
as of the day and year first above written.


BORROWER:                            CHATTEM, INC.

                                     By: _________________________________
                                     Name: _______________________________
                                     Title: ______________________________



GUARANTORS:                          SIGNAL INVESTMENT & MANAGEMENT CO.,
                                     a Delaware corporation

                                     By: _________________________________
                                     Name: _______________________________
                                     Title: ______________________________


                                     SUNDEX, LLC,
                                     a Tennessee limited liability company

                                     By: _________________________________
                                     Name: _______________________________
                                     Title: ______________________________


                                     CHATTEM (CANADA) HOLDINGS, INC.,
                                     a Delaware corporation

                                     By: _________________________________
                                     Name: _______________________________
                                     Title: ______________________________



AGENT:                               BANK OF AMERICA, N.A.,
                                     in its capacity as Agent

                                     By: _________________________________
                                     Name: _______________________________
                                     Title: ______________________________
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LENDERS:                             BANK OF AMERICA, N.A.,
                                     in its capacity as a Lender, including
                                     as Issuing Lender and Swing Line Lender

                                     By: _________________________________
                                     Name: _______________________________
                                     Title: ______________________________


                                     NATIONAL CITY BANK,
                                     in its capacity as a Lender

                                     By: _________________________________
                                     Name: _______________________________
                                     Title: ______________________________


                                     SUNTRUST BANK, in its capacity as a Lender

                                     By: _________________________________
                                     Name: _______________________________
                                     Title: ______________________________


                                     BRANCH BANKING AND TRUST,
                                     in its capacity as a Lender

                                     By: _________________________________
                                     Name: _______________________________
                                     Title: ______________________________