Amended and Restated Distribution and License Agreement



 Exhibit 10.35 
 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 
 AMENDED AND RESTATED DISTRIBUTION AND LICENSE AGREEMENT 
 This Amended and Restated Distribution and License Agreement (hereinafter, the “Restated License
Agreement”), which amends and restates the Distribution and License Agreement, dated as of the 1st day of December, 2005 (hereinafter, as amended to date pursuant to that certain First Amendment, dated as of the 15
th day of May, 2009, the “Original
Agreement”), between XenoPort, Inc., a Delaware corporation having a place of business at 3410 Central Expressway, Santa Clara, CA 95051, United States of America (“XenoPort”), and Astellas Pharma Inc., a Japanese
corporation having a place of business at 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo, 103-8411, Japan (“Astellas”), is entered into and made effective as of the 31st day of October, 2009 (the “Restatement Effective
Date”). Each of XenoPort and Astellas shall be a “Party” and, together, the “Parties.” 
 RECITALS 
 A. XenoPort is developing a Transported ProdrugTM of gabapentin (as further defined
below, the “Product”) in the United States, for the treatment of restless legs syndrome (“RLS”) and the management of neuropathic pain; 
 B. Astellas desires to further develop and commercialize the Product in Japan and certain other countries (as further described below, the “Territory”), and XenoPort desires to have the
Product developed and commercialized in the Territory by Astellas, in accordance with this Agreement; 
 C. The Parties have
previously entered into the Original Agreement, pursuant to which XenoPort has granted to Astellas certain exclusive distribution and license rights for the Product in the Territory; 
 D. Astellas now wishes to be responsible for the manufacture of clinical and commercial supplies of the Compound and/or Product and the
Product Formulation (as further defined below) for the development and commercialization of the Product in the Territory; and 
 E. The Parties now wish to amend and restate in its entirety the Original Agreement with this Restated License Agreement. 







 NOW, THEREFORE, the Parties hereby agree as follows: 
 AGREEMENT 
 1. DEFINITIONS 
 1.1 “Affiliates” shall mean, in the case of a subject entity, another
entity that controls, is controlled by or is under common control with the subject entity, for so long as such control exists. For purposes of this definition only, “control” shall mean beneficial ownership (direct or indirect) of at least
fifty percent (50%) of the shares of the subject entity entitled to vote in the election of directors (or, in the case of an entity that is not a corporation, in the election of the corresponding managing authority).
“Subsidiaries” of a subject entity shall mean Affiliates that are controlled by such entity. 
 1.2
“Agreement” shall mean the Original Agreement, as in effect from the Effective Date until the Restatement Effective Date, together with the Restated License Agreement, which replaces the Original Agreement in its entirety as of the
Restatement Effective Date. 
 1.3 “Astellas Know-How” shall mean any and all scientific, medical, technical
and/or regulatory information relating to the Compound and/or the Product and Data, which are owned or Controlled by Astellas as of the Effective Date or during the term of this Agreement, which are needed by or reasonably useful to XenoPort in
order to develop and/or commercialize the Product outside the Territory. Astellas Know-How shall include any developments and improvements relating to the Compound and/or the Product made by Astellas during the term of this Agreement.
Notwithstanding the foregoing, Astellas Know-How shall not include Astellas Manufacturing Know-How. 
 1.4 “Astellas
Manufacturing Know-How” shall mean any and all scientific, medical, technical and/or regulatory information and Data relating to manufacture of the Compound, the Material and/or the Product, which are owned or Controlled by Astellas as of
the Effective Date or during the term of this Agreement, which are needed by or reasonably useful to XenoPort in order to manufacture the Product outside the Territory. Astellas Manufacturing Know-How shall include any developments and improvements
relating to manufacture of the Compound, the Material and/or the Product made by Astellas during the term of this Agreement. 
 1.5 “Batch” means a specific quantity of Compound comprised of a number of units as set forth in the applicable master batch record(s), and that (a) is intended to have uniform character and quality within its
specifications and (b) is produced according to a single production order during the same cycle of production. 
 1.6
“Competitive Compound” shall mean any compound having as a primary mechanism of action [... * ...], other than the Compound. For avoidance of doubt, Competitive Compound shall not include any compound that has a
mechanism of action [... * ...]; provided, however, that such compound [... * ...] by either Party, including without limitation RLS and painful diabetic neuropathy. 
 1.7 “Compound” shall mean that certain compound, referred to internally at XenoPort as XP13512, the structure of which is
set forth in Exhibit A, and all isomers and/or mixtures of isomers thereof. 
  

  

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 1.8 “Control” shall mean possession of the ability to grant a license
or sublicense, of or within the scope set forth in this Agreement, without violating the terms of any agreement or other arrangement with any Third Party. 
 1.9 “Data” shall mean all preclinical data, clinical data, clinical pharmacology data and all regulatory filings and approvals submitted or obtained, together with its supporting data and
regulatory correspondence and rights to reference the same, in each case pertaining to the Compound and/or the Product, which are Controlled by each Party as of the Effective Date or during the term of this Agreement. 
 1.10 “Diligent Efforts” shall mean the level of efforts required to carry out a particular task or obligation in a
sustained manner, consistent with the efforts generally used by a Party with respect to its own compounds, with the same level of peak sales potential, for which Marketing Approval is being sought as expeditiously as practicable or for which
Marketing Approval has been obtained, as the case may be. 
 1.11 “Effective Date” shall mean December 1,
2005, the effective date of the Original Agreement. 
 1.12 “First Commercial Sale” shall mean the first
bona fide, arm’s length sale of a Product in a country following receipt of Marketing Approval of such Product in such country; provided that where such a first sale has occurred in a country for which government pricing or government
reimbursement approval is needed and Astellas chooses to apply for such approval, then such sales shall not be deemed a First Commercial Sale until such pricing or reimbursement approval has been obtained.
 1.13 “Field” shall mean any and all indications for human use. 
 1.14 “GSK” shall mean Glaxo Group Limited, a company existing under the laws of England and Wales (d/b/a GlaxoSmithKline),
having its registered office at Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex, UB6 0NN, England, and its Affiliates. 
 1.15 “GSK Agreement” shall mean the License and Services Agreement dated September 24, 2009 between Astellas and GSK. 
 1.16 “IND” shall mean an Investigational New Drug application filed with the U.S. Food and Drug Administration (“FDA”), or a comparable filing in the Territory.

 1.17 “Lonza” shall mean Lonza Ltd., a company existing under the laws of Switzerland, having a place of
business at Muenchensteinerstrasse 38, CH-4002 Basel, Switzerland, and its Affiliates, including Lonza Japan Ltd. 
  

  

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AMENDED. 









 1.18 “MAA” shall mean a New Drug Application filed with the FDA (or, in the
Territory, a marketing authorization application comparable to such New Drug Application), including all supporting documentation and data required for such application to be accepted for review, filed with the FDA or counterpart health regulatory
agency, requesting approval for commercialization of a product for a particular indication in such country. 
 1.19
“Marketing Approval” shall mean, with respect to the United States or in the Territory, approval by the health regulatory agency in such country that is the counterpart of the FDA of the MAA for a product filed in such country. It
is understood that, as used herein, Marketing Approval does not include pricing or reimbursement approval. 
 1.20
“Material” shall mean analogues, metabolites, impurities, degradates and radio-labeled compounds and standard materials, i.e., defined, highly purified compound for the purposes of conducting analytical, release and other studies.

 1.21 “Net Sales” shall mean the gross amounts invoiced or otherwise received for sales of the Product by
Astellas, its Affiliates and Subdistributors to Third Parties (but not including sales among Astellas, its Affiliates and their respective Subdistributors) less deductions for: (a) customary trade, quantity and cash discounts allowed and
actually taken; (b) credits to customers on account of return of Product; (c) [... * ...] of such gross amount to cover outbound transportation charges, including insurance, freight and packaging; and (d) sales and excise
taxes and duties and any other similar governmental charges imposed upon the sale of Product to the customer. Notwithstanding the foregoing, the amounts described in (c) and (d) above shall be deducted only to the extent they are stated
separately on the invoice and included within gross amounts received from sales of the Product. If a Product is sold for consideration other than solely cash, the monetary value of such other consideration shall be included in the calculation of Net
Sales. 
 1.22 “Patheon” shall mean Patheon Pharmaceuticals Inc, a Delaware corporation, having a place of
business at 2110 East Galbraith Road, Cincinnati, Ohio 45237-1625. 
 1.23 “Phase III Trial” shall mean human
clinical trial(s), the principal purpose of which is to establish safety and efficacy of the Product against the disease being studied as required in 21 C.F.R. §312.21(c) or a similar clinical study in a country other than the United States.
For clarity, a Phase III Trial shall also include any other human clinical trial intended as a pivotal trial for filing an MAA, whether or not such trial is a traditional Phase III Trial. 
 1.24 “Product” shall mean (a) the pharmaceutical product containing the Compound that is the subject of IND Nos.
68,341 and 71,352 (the “Existing Product”), and (b) any changes to the formulation, dosage form or other aspects of the Existing Product established by the Parties pursuant to Section 4.3 or otherwise, provided that the
result remains a pharmaceutical product containing the Compound, alone or in combination with other active ingredients. 
  

  

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PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 1.25 “Product Formulation” shall mean all processes and activities
typically engaged in by a person or entity in the pharmaceutical industry for formulation and packaging of: (a) placebo tablets; and (b) the Product from the Compound; including, without limitation, vendor selection, contract negotiation,
vendor management, scheduling, manufacturing process and formulation development, validation and scale-up, coating, packaging, labeling and shipping, storage, quality control and assurance, release testing, process improvement and support for
inspections. 
 1.26 “Product Trademark” shall mean the trademark identified by XenoPort for the Product in the
Territory, or another mutually agreed trademark for the Product.
 1.27 “Regulatory Authority” shall mean any
national (e.g., the FDA or MHLW), supra-national (e.g., the European Commission, the Council of the European Union or the EMEA), or other governmental entity in any jurisdiction of the world involved in the granting of Marketing Approval for
pharmaceutical products. 
 1.28 “Subdistributor” shall mean an entity to whom Astellas has granted directly or
indirectly the right to market, distribute and/or promote, a Product in the Territory in accordance with Section 2.3. For avoidance of doubt, “Subdistributor” shall not include a wholesaler who is not primarily responsible for
marketing and promoting the Product for its respective territory or customer group. 
 1.29 “Territory” shall
mean Indonesia, Japan, Korea, Philippines, Taiwan and Thailand. 
 1.30 “Third Party” shall mean any person or
entity other than Astellas, XenoPort and their Affiliates.
 1.31 “Valid Claim” means (a) a claim of any
issued, unexpired patent rights which has not been revoked or held unenforceable or invalid by a decision of a court or governmental agency of competent jurisdiction from which no appeal can be taken, or with respect to which an appeal is not taken
within the time allowed for appeal, and which has not been disclaimed, denied or admitted to be invalid or unenforceable through reissue, disclaimer or otherwise; and (b) a claim in any patent application pending with an administrative patent
authority unless the application has been (i) abandoned, or (ii) rejected by the relevant patent authority and all options for appeal to the relevant administrative patent authority for further prosecution of such claim have been
exhausted. 
 1.32 “XenoPort Patent Rights” shall mean all issued, unexpired patents and all reissues,
renewals, re-examinations and extensions thereof, and patent applications therefor, and any divisions or continuations, in whole or in part, thereof, including those patents and applications set forth in Exhibit B, which would, but for the license
granted hereunder, be infringed by use, development, manufacture, formulation, packaging, import, sale, distribution, promotion or marketing of the Compound and/or the Product by

  

  

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PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 
Astellas, any of its Affiliates or Subdistributors in the Territory (and countries outside the Territory, to the extent the Compound and/or the Product is manufactured, formulated or packaged
pursuant to Section 2.2 in such countries, or where Astellas conducts or, requests XenoPort to conduct, development activities in such countries pursuant to Section 4.7), to the extent Controlled by XenoPort as of the Effective Date or
during the term of this Agreement. 
 1.33 “XenoPort Know-How” shall mean any and all scientific, medical,
technical and/or regulatory information relating to the Compound and/or the Product and Data, which are owned or Controlled by XenoPort as of the Effective Date or during the term of this Agreement, which are needed by or reasonably useful to
Astellas in order for Astellas to perform its obligations under this Agreement. XenoPort Know-How shall include any developments and improvements relating to the Compound and/or the Product made by XenoPort during the term of this Agreement.

 In addition, the following terms shall have the meaning described in the corresponding section of this Agreement. Other terms
may be defined throughout the Agreement. 
  

									
	 Term
	  	 Section
	  	 	  	 Term
	  	 Section

	accepted	  	6.2.3	  		  	Infringement Action	  	10.3
	Acquisition	  	2.4.2	  		  	Infringing Product	  	10.4
	Affected Area	  	16.2	  		  	JAMS	  	17.2
	Annual Net Sales	  	7.1	  		  	Joint Development Committee, JDC	  	3.2
	Astellas	  	Preamble	  		  	Joint Steering Committee, JSC	  	3.1
	Astellas Development Plan	  	4.2.2	  		  	Liabilities	  	14.1
	Astellas Indemnitees	  	14.2	  		  	M&A Acquired Product	  	2.4.2
	Change of Control	  	2.4.2	  		  	[... * ...]	  	
	[... * ...]	  		  		  	[... * ...]	  	
	Commercialization Plan	  	5.1.1	  		  	[... * ...]	  	
	completion	  	6.2.2	  		  	Original Agreement	  	Preamble
	Confidential Information	  	12.1	  		  	Party, Parties	  	Preamble
	CMC Information	  	13.2.4	  		  	Panel	  	17.2.1
	Damages	  	10.3	  		  	Product Liability Claim	  	14.4
	DMF	  	4.5	  		  	Product Materials	  	16.2.5
	Enforcement Action	  	10.4	  		  	Recall Costs	  	8.2
	Existing Product	  	1.24	  		  	[... * ...]	  	
	Fault of Astellas	  	8.2	  		  	Restated License Agreement	  	Preamble
	Fault of XenoPort	  	8.2	  		  	Restatement Effective Date	  	Preamble
	FDA	  	1.16	  		  	RLS	  	Preamble
	Force Majeure	  	18.2	  		  	Royalty Rate	  	7.1
	Generic Product	  	7.3.3	  		  	second indication	  	6.2.7(a)
	Improvements	  	10.1	  		  	Subsidiaries	  	1.1
	Indemnitee, Indemnitor	  	14.3	  		  	third indication	  	6.2.7(b)
	Third Party Claim	  	14.1	  		  	Written Disclosure	  	12.4
	Third Party IP	  	2.5	  		  	XenoPort	  	Preamble
	Third Party Royalties	  	7.3.1	  		  	XenoPort Indemnitees	  	14.1
	Wind-down Period	  	16.2.1(b)	  		  	[... * ...]	  	

  

  

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PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
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 2. GRANT OF DISTRIBUTION RIGHTS AND LICENSE 
 2.1 Appointment. During the term of this Agreement, XenoPort appoints Astellas, and Astellas hereby accepts such appointment, as
the exclusive (even as to XenoPort) distributor and marketer of the Product in the Territory. 
 2.2 License. Subject to
the terms and conditions of this Agreement, XenoPort hereby grants to Astellas an exclusive license during the term of this Agreement under the XenoPort Patent Rights and XenoPort Know-How to: (a) formulate, have formulated, package and have
packaged the Product using the Compound; and (b) develop, make, have made, use, market, import, export, sell, distribute and promote the Compound and the Product; in each case for use in the Field. Such license shall be limited solely to the
Territory, except that Astellas has the non-exclusive right to make, have made, formulate and have formulated the Compound, formulate and have formulated the Product, and package and have packaged the Product, outside the Territory, in each case
solely for sale of the resulting Product within the Territory. The rights and licenses in Section 2.2(a) and 2.2(b) shall be exclusive even as to XenoPort, except with respect to [... * ...] in accordance with [... *
...] 
 2.3 Subdistributors. Astellas shall have the right to engage its Subsidiaries as Subdistributors of the
Product, and may grant sublicenses under Section 2.2 to such Subsidiaries solely for such purposes, solely for as long as such entity remains a Subsidiary. Astellas may otherwise engage Subdistributors and grant sublicenses only upon the
approval of XenoPort, which approval shall not be unreasonably withheld or delayed. In any event, Astellas shall ensure that all of its Subdistributors are bound by a written agreement containing provisions as protective of the Product and XenoPort
as this Agreement. Without limiting the foregoing, in the event that Products supplied by Astellas to a Subdistributor are being directly or indirectly sold or used outside the Territory, Astellas agrees that, upon becoming aware of such sale or use
or otherwise upon the request of XenoPort, it shall not supply further quantities of Products to such Subdistributor. 
 2.4
No Conflict.
 2.4.1 Competitive Compounds. In the event that Astellas and its Affiliates shall, by themselves or
through any Third Party(ies): (a) [... * ...] (b) [... * ...], prior to [... * ...] anywhere in the world [... * ...] regarding a product containing Competitive Compound(s), [... *
...] with the Product, [... * ...] XenoPort under this Section 2.4.1 and XenoPort shall [... * ...]. 
 2.4.2 Notice of M&A Acquired Product. In the event of a Change of Control or Acquisition, whereby [... * ...] prior to such Change of Control [... * ...] and whether
Astellas or its Affiliate [... * ...] above. In the event Astellas [... * ...] as the case may be, shall not apply with respect to [... * ...]. However, in such event, unless XenoPort and Astellas [... *
...] upon written notice,

  

  

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which shall be [... * ...] and XenoPort shall [... * ...]. In the event Astellas [... * ...] fully apply with respect to [... * ...]. As used
herein, “Change of Control” means (a) a merger involving Astellas, in which the shareholders of Astellas immediately prior to such merger cease to control (as defined in Section 1.1) Astellas after such merger, (b) a
sale of all or substantially all of the assets of Astellas to an acquiring entity or (c) a sale of a controlling (as defined in Section 1.1) interest of Astellas to an acquiring entity. As used herein, “Acquisition” means
(a) a merger involving Astellas, in which the shareholders of Astellas immediately prior to such merger does not cease to control (as defined in Section 1.1) Astellas after such merger, or a merger involving an Affiliate of Astellas in
which the resulting entity remains an Affiliate of Astellas after such merger, (b) an acquisition of all or substantially all of the assets of an acquired entity by Astellas or an Affiliate or (c) a sale of a controlling (as defined in
Section 1.1) interest of an acquired entity to Astellas or an Affiliate. 
 2.4.3 Ex-Territory; No Exploitation except
as Licensed. Except as provided in Section 2.2, neither Astellas nor its Affiliates will develop, file for Marketing Approval with respect to, use, make, have made, market, import, export, distribute, promote or sell the Compound and/or
Product anywhere in the world, except in the Territory, and, within the Territory, only in accordance with and under this Agreement. Astellas agrees that it and its Affiliates shall not use nor otherwise exploit XenoPort Patent Rights, XenoPort
Know-How and the Product Trademark, except as licensed in this Agreement. 
 2.4.4 Sale of Compounds Only as Part of
Products. Astellas agrees that it shall not, and shall ensure that its Affiliates and Subdistributors do not, sell or otherwise make commercially available the Compound, other than as part of a Product. This Section 2.4.4 shall not,
however, prohibit sales of Compounds among Astellas, its Affiliates and/or Subdistributors, provided that such Compounds will be incorporated into Products for resale by such entities, nor prohibit Astellas, its Affiliates and/or Subdistributors
from exercising their rights under Section 2.2 to “have” formulated or “have” packaged the Compound. 
 2.4.5 Wind-down Period. For avoidance of doubt, Sections 2.4.1 and 2.4.2 shall not apply during the Wind-down Period with respect to the Affected Area. 
 2.5 XenoPort IP Acquired after the Effective Date. If, after the Effective Date, XenoPort acquires from a Third Party subject matter within the XenoPort Patent Rights and XenoPort Know-How
(“Third Party IP”) that is subject to royalty or other payment obligations to such Third Party, then the following shall apply. The licenses granted under Section 2.2 above with respect to such Third Party IP shall be subject
to Astellas promptly reimbursing XenoPort for any milestones, royalties or other amounts that become owing to such third party by reason of Astellas’ exercise of rights granted in this Agreement with respect to the Third Party IP. Upon request
by Astellas, XenoPort shall disclose to Astellas a true, complete and correct written description of such payment obligations, and Astellas’ obligation to reimburse such amounts following such request shall be limited to those payment
obligations

  

  

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as so disclosed by XenoPort. In the event Astellas does not promptly reimburse XenoPort for such amounts upon request, then such Third Party IP shall thereafter be deemed excluded from the
XenoPort Patent Rights and XenoPort Know-How hereunder. The reimbursement made by Astellas to XenoPort under this Section 2.5 may then be treated by Astellas as Third Party Royalty payments under Section 7.3.1 below. 
 2.6 No Other Rights; No License to Other Therapeutically Active Components. Except for the rights and licenses expressly granted in
this Agreement, each Party retains all rights under its intellectual property, and no additional rights shall be deemed granted to the other Party by implication, estoppel or otherwise. The licenses and rights granted in this Agreement shall not be
construed to convey any licenses or rights under the XenoPort Patent Rights with respect to any active ingredients other than the Compound. 
 3. GOVERNANCE 
 3.1 Joint Steering Committee. The Parties
shall establish a committee (the “Joint Steering Committee” or “JSC”) to oversee the Party’s collaboration relating to the Product in the Territory. The JSC will consist of two (2) representatives from
each Party, each of whom shall be a senior executive of a Party. In case a representative of a Party is unavailable for a scheduled JSC meeting, upon reasonable notice to the other Party, such Party may substitute in place of such representative for
such meeting, a competent person who is authorized by such Party to act on matters that will be presented to the JSC at such meeting. 
 3.1.1 Meetings. The JSC shall meet at least once annually during the term of this Agreement, unless otherwise agreed by the Parties. Such meeting(s) shall be in person at least once per year, alternating between the facilities of
each Party unless otherwise mutually agreed, and the other meetings may be through telephone or video conference or other mutually agreeable means. At the discretion of each Party, other representatives of XenoPort or Astellas may attend JSC
meetings as non-voting observers. Each Party shall bear its own personnel and travel costs and expenses relating to JSC meetings. 
 3.1.2 Responsibility. The JSC will (a) serve as a forum for keeping each Party informed as to material matters in connection with the development, manufacturing and commercialization of the Product in and outside of the
Territory, (b) provide strategic direction to the JDC, (c) resolve any disputed matters submitted to the JSC by the JDC under Section 3.2.3 below, (d) review and discuss the Commercialization Plan, any updates, modifications and
additions thereto submitted to the JSC pursuant to Section 5.1.1 below, and the progress of Astellas thereunder and (e) undertake and/or approve such other matters as are provided for the JSC under this Agreement, or otherwise agreed by
the Parties. 
  

  

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 3.1.3 Decisions. The objective of the JSC shall be [... * ...] on the
JSC. If the JSC cannot reach agreement on any determination or decision for which it is responsible within [... * ...] after the date such matter was initially referred to the JSC, the dispute shall be referred to [... *
...] to resolve the dispute. If, [... * ...] deciding vote with respect to [... * ...], unless the matter (a) would materially adversely affect [... * ...], (b) would change [... *
...], (c) would involve [... * ...] or [... * ...], or (d) involves [... * ...] for the Compound and/or Product in the Territory. It is understood that the JSC shall [... * ...].
If the Parties are unable to resolve a dispute with respect to matters described in Sections 3.1.3(a), (b), (c) or (d), the Parties shall [... * ...] and until such resolution, neither Party shall proceed with a course of action
that is claimed to fall within Sections 3.1.3(a) through (d) above. 
 3.2 Joint Development Committee. The
Parties shall establish a committee (the “Joint Development Committee” or “JDC”) to oversee the development efforts relating to the Product in the Territory. The JDC will consist of three (3) representatives
from each Party, at least one of whom shall be a senior executive of each Party. In case a representative of a Party is unavailable for a scheduled JDC meeting, upon reasonable notice to the other Party, such Party may substitute in place of such
representative for such meeting, a competent person who is authorized by such Party to act on matters that will be presented to the JDC at such meeting. 
 3.2.1 Meetings. The JDC shall meet once each calendar quarter until the first filing of MAA with respect to the Product in the Territory, and twice annually thereafter, during the term of this
Agreement, unless otherwise agreed by the Parties. Such meetings shall be in person at least twice per year until the first filing of MAA with respect to the Product in the Territory, alternating between the facilities of each Party unless otherwise
mutually agreed, and the other meetings may be through telephone or video conference or other mutually agreeable means. With the consent of the JDC members, other representatives of XenoPort or Astellas may attend JDC meetings as non-voting
observers. Each Party shall bear its own personnel and travel costs and expenses relating to JDC meetings. 
 3.2.2
Responsibility. The JDC will (a) review and approve the Astellas Development Plan, including the initial Astellas Development Plan pursuant to Section 4.2.2 and any updates, modifications or additions thereto submitted to the JDC
pursuant to Section 4.2.3 below, (b) oversee the implementation of the Astellas Development Plan, (c) review and approve protocols for any clinical trials of Product in the Territory, (d) review and approve the translated
summaries of any regulatory filings for Products in the Territory (including the precise wording of the label), which shall be provided by Astellas to the JDC in the English language, (e) facilitate the exchange of Data and other information
and/or materials between the Parties, (f) review and approve manufacturing plans for the Compound and the Product and (g) undertake and/or approve such other matters as are provided for the JDC under this Agreement or otherwise agreed by
the Parties. 
 3.2.3 Decisions. Decisions of the JDC shall be by unanimous approval of its members, with at least one
(1) representative of each of Astellas and XenoPort voting on the matter; provided, however, if the JDC cannot reach agreement on a matter within [... * ...] after the date such matter was initially referred to the JDC, the dispute
shall be referred to the JSC who shall meet promptly and negotiate in good faith to resolve the dispute in accordance with Section 3.1.3 above. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 3.3 Limited Authority. Notwithstanding the creation of the JSC and JDC, each
Party shall retain the rights, powers and discretion granted to it hereunder, and the JSC and JDC shall not be delegated or vested with such rights, powers or discretion unless such delegation or vesting is expressly provided herein or the Parties
expressly so agree in writing. The JSC and JDC shall not have the power to amend or modify this Agreement, and its decisions shall not be in contravention of any terms and conditions of this Agreement. It is understood and agreed that issues to be
formally decided by the JSC and JDC are only those specific issues that are expressly provided in this Agreement to be decided by the JSC and JDC. 
 4. DEVELOPMENT 
 4.1 Development. 
 4.1.1 Subject to oversight by the JDC, Astellas shall be responsible for: (a) conducting, and shall use Diligent Efforts to conduct,
such clinical trials and to obtain such regulatory approvals, including Marketing Approvals and pricing and/or reimbursement approval, as may be necessary to commercialize the Product in each country in the Territory, in accordance with the Astellas
Development Plan; and (b) manufacturing, and shall use Diligent Efforts to manufacture, Compound and Product necessary to support such clinical trials and regulatory approvals, including Marketing Approvals and pricing and/or reimbursement
approval, as may be necessary to commercialize the Product in each country in the Territory. Without limiting the foregoing, Astellas agrees to use Diligent Efforts to conduct such clinical trials and to obtain, as soon as practical, Marketing
Approval of the Product for RLS and painful diabetic neuropathy in the Territory. Astellas agrees to keep XenoPort reasonably informed as to the progress of its clinical development, manufacturing and regulatory activities relating to the Product in
the Territory, including its correspondence and meetings with regulatory agencies, by way of updates to the JDC at its meetings and as otherwise reasonably requested by XenoPort. Astellas agrees to reasonably consider and promptly respond to any
comments provided by XenoPort with respect to such clinical development and regulatory activities. It is understood and agreed that all development and manufacturing efforts for the Product in the Territory shall be at the sole cost and expense of
Astellas, and shall be conducted in accordance with the Astellas Development Plan described below. 
 4.1.2 XenoPort or its
licensee(s) shall be responsible for all development, manufacturing and regulatory activities of the Product outside the Territory. XenoPort agrees to keep Astellas reasonably informed as to the progress of its and/or [... * ...] its
other licensees’ clinical development, manufacturing and regulatory activities relating to the Product outside the Territory, including their correspondence and meetings with regulatory agencies, by way of updates to the JDC at its meetings and
as otherwise

  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 
reasonably requested by Astellas. XenoPort agrees to reasonably consider and promptly respond to any comments provided by Astellas with respect to such clinical development, manufacturing and
regulatory activities. It is understood and agreed that all development efforts for Product outside the Territory shall be at the sole cost and expense of XenoPort, its Affiliates or its other licensee(s), provided that any development efforts
conducted for the Territory requested by Astellas pursuant to Section 4.7 shall be at the sole cost and expense of Astellas. 
 4.2 Astellas Development Plan. 
 4.2.1 An initial, preliminary development plan for Astellas’ development
of the Product in the Territory is set forth in Exhibit C. For avoidance of doubt, such initial, preliminary development plan is not intended to create or constitute any legally binding obligation among the Parties. 
 4.2.2 Within [... * ...] after the Effective Date, the JDC shall discuss and approve the plan for Astellas’ development
of the Product in the Territory (the “Astellas Development Plan”). Astellas acknowledges and agrees that each Party desires that Astellas commit to conduct development of the Compound and/or Product in the Territory for both the RLS
and painful diabetic neuropathy indications, in a manner to be described by the JDC in the Astellas Development Plan; and the JDC shall, during the discussion of such development, take into account an expected selling price of the Product, expected
launch time for respective indications, communications with the Regulatory Authority in the Territory, advice of the experts in the Territory, possibility of bridging use of the Data obtained by XenoPort from its pre-clinical studies and/or clinical
trials of the Product outside the Territory for development in the Territory and any other relevant regulatory and business matters. 
 4.2.3 Astellas agrees to provide to the JDC for its review and approval, which approval shall not be unreasonably withheld or delayed, updated versions of the Astellas Development Plan at least annually, and any modification or addition to
the Astellas Development Plan within a reasonable period of time prior to adoption and implementation thereof. 
 4.3 Change
in Formulation. Before modifying or creating a new formulation or dosage form of the Product, or developing the Compound in combination with another active ingredient, Astellas shall discuss the proposed modifications or development with
XenoPort at the JSC and obtain the approval of the JSC, which approval shall not be unreasonably withheld or delayed. Subject to Section 3.1.3(b), XenoPort agrees that Astellas may conduct formulation studies on the Compound that were so
discussed and approved by the JSC for the purpose of developing and commercializing pharmaceutical formulations of the Compound as a sole active ingredient. 
  

  

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PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 4.4 Exchange of Data and Know-How. Promptly after the Effective Date, XenoPort shall
provide Astellas with any and all XenoPort Know-How that XenoPort considers as necessary or reasonably useful for Astellas to develop and/or commercialize the Product in the Territory, including but not limited to, any and all Data from any and all
clinical trials and preclinical studies of the Compound and/or Product that are completed as of the Effective Date. During the term of this Agreement, each Party shall provide to the other Party all Data (and, in case of XenoPort, any and all
additional XenoPort Know-How, and in the case of Astellas, any and all Astellas Know-How and Astellas Manufacturing Know-How) Controlled by such Party, (a) that such Party considers as necessary or reasonably useful for the other Party to
develop and/or commercialize the Product in the Territory (in the case of Astellas) or outside the Territory (in the case of XenoPort), in a timely fashion and as promptly as possible or (b) upon the reasonable request of the other Party; in
each case, for use by such other Party in accordance with this Section 4.4. Promptly after May 15, 2009, XenoPort shall disclose to Astellas any and all undisclosed Data and XenoPort Know-How relating to manufacture of the Compound, the
Material and the Product and Product Formulation that is Controlled by XenoPort (the “XenoPort Manufacturing Know-How”). XenoPort shall grant Astellas, its Affiliates or Third Parties the right to use the XenoPort Manufacturing
Know-How for the sole purpose of developing and commercializing the Product in the Territory and under reasonable and customary confidentiality restrictions. 
 4.4.1 Use; Disclosure. Astellas will use and disclose Data, XenoPort Know-How and XenoPort Manufacturing Know-How to its Affiliates or Third Parties only as required to obtain Marketing
Approval for the Product in the Territory and/or as may be necessary in performing its obligations and exercising its rights under this Agreement (including, but not limited to, the use of such Data, XenoPort Know-How and XenoPort Manufacturing
Know-How to manufacture clinical and commercial supplies of Compound and/or Product pursuant to Section 8 and to design development activities outside the Territory for Section 4.7), in each case solely to the extent necessary for
development and commercialization of the Product in the Territory and under reasonable and customary confidentiality restrictions. Astellas may not use any Data, XenoPort Know-How or XenoPort Manufacturing Know-How (or permit any Affiliates or Third
Party to use Data, XenoPort Know-How or XenoPort Manufacturing Know-How) outside the Territory (other than pursuant to Sections 4.7 and 8.1), nor for any products other than the Product. XenoPort may only use, and disclose to Affiliates and Third
Parties, Data, Astellas Know-How and Astellas Manufacturing Know-How provided by Astellas as is reasonably necessary or useful for developing, manufacturing and/or commercializing the Product outside the Territory, including for cross-referencing
drug master files or other regulatory filings by XenoPort, its Affiliates or Third Parties, provided that the disclosure of such Data, Astellas Know-How and Astellas Manufacturing Know-How to a non-governmental Third Party is made under reasonable
and customary confidentiality restrictions, and complies with Section 4.4.2 below. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 4.4.2 Other Licensee(s). XenoPort shall [... * ...] under this
Section 4.4 [... * ...] to the extent that [... * ...]. It is understood that [... * ...], shall not be [... * ...]. However, XenoPort agrees [... * ...] except to the extent
[... * ...]. Promptly after May 15, 2009, XenoPort shall use [... * ...] that is [... * ...] and under [... * ...]. Promptly after the Restatement Effective Date, XenoPort shall use [...
* ...] that are [... * ...] and under [... * ...]. It is understood that [... * ...], shall not be [... * ...]. 
 4.5 Regulatory Matters. Subject to Section 16.2.2 below, all regulatory filings for the Product, including the MAA and Marketing Approvals, in the Territory shall be in the name of Astellas in
Japan, or its Affiliate(s) or Subdistributor(s) in countries other than Japan. Astellas shall, or shall cause its Affiliate(s) or its Subdistributor(s) to, be responsible for the filing thereof, the payment of fees and all other associated costs,
for monitoring clinical experiences and filing associated reports and fulfilling all of its regulatory obligations throughout the development and commercialization of the Product in the Territory. Notwithstanding the foregoing, XenoPort may, and if
elected by XenoPort shall be responsible to, file and keep a Drug Master File (“DMF”) in the Territory at its expense in its own name or in the name of its suppliers with respect to the bulk supply of the Compound and shall permit
Astellas, its Affiliates and its Subdistributors to cross-reference such DMF in their regulatory filings for the Product in the Territory. 
 4.6 Development within the Territory. Astellas shall commence, promptly after the Effective Date, its development of the Product in Japan in accordance with this Section 4. The Parties
recognize, however, that Astellas’ development and commercialization of the Product in countries of the Territory other than Japan may not be achieved, if ever, until a later date as is customary for pharmaceutical launches in Asia, and may
depend upon (a) whether the Data obtained by XenoPort and/or by Astellas from their respective pre-clinical studies and/or clinical trials of the Product may be used for obtaining Marketing Approval of the Product in such country(ies) and
(b) whether commercialization of the Product in such country(ies) would be commercially feasible under the terms and conditions of this Agreement. Subject to the foregoing, a decision by Astellas not to develop and/or commercialize a Product in
a country of the Territory other the Japan shall not by itself be deemed a breach of its obligations to use Diligent Efforts under this Agreement with respect to such country, provided that Astellas can and does promptly terminate this Agreement
with respect to such country pursuant to Section 15.2 below. 
 4.7 Cooperation in Development. The Parties
acknowledge that, from time to time, Astellas may, or may request XenoPort to, conduct activities outside the Territory (for example, to conduct certain clinical trials in the United States on Japanese subjects) for use in obtaining Marketing
Approval of the Product in the Territory. Any activities outside the Territory conducted or requested by Astellas pursuant to this Section 4.7 shall be subject to the consent of XenoPort, which consent shall not be unreasonably withheld or
delayed. Subject to such consent, XenoPort shall cooperate as mutually agreed to perform such activities, the cost of which shall be reimbursed by Astellas (including without limitation payment of the supply price of the clinical supplies used in
such activities, in accordance with any supply agreement between the Parties then in effect). 
  

  

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PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 4.8 Astellas Know-How and Astellas Manufacturing Know-How. All results, data,
information, know-how and technology obtained by Astellas or its Affiliates in the course of development or manufacturing activities with respect to the Compound and/or the Product conducted by Astellas or any of its Affiliates shall be solely owned
by Astellas or such Affiliates. Subject to Section 2.3(a) of the GSK Agreement and Sections 4.4 and 10.1 of this Agreement, during the term of this Agreement, Astellas shall solely own or Control all right, title and interest in and to the
know-how and technology owned or Controlled by Astellas which Astellas may decide to use for manufacturing the Compound and Product or modifying or creating a new formulation or dosage form of the Product in accordance with Section 4.3.

 5. COMMERCIALIZATION 
 5.1 Commercialization.
 5.1.1 Subject to oversight by the JSC, Astellas
shall be responsible for: (a) launching and commercializing, and shall use Diligent Efforts to launch and commercialize, the Product in each country in the Territory in accordance with a commercialization plan submitted by Astellas to the JSC
(“Commercialization Plan”); and (b) manufacturing, and shall use Diligent Efforts to manufacture, the Compound and Product necessary to support the launching and commercialization of the Product in each country in the Territory
in accordance with the Commercialization Plan. Without limiting the foregoing, Astellas agrees to use Diligent Efforts to launch the Product as soon as practicable in the Territory, and thereafter to manufacture, market, promote and sell such
Product and to maximize the Net Sales of the Product in the Territory. Astellas agrees to provide to the JSC updated versions of the Commercialization Plan at least annually, and any material modification or addition to the Commercialization Plan
within a reasonable period of time prior to adoption and implementation thereof. Astellas shall keep XenoPort reasonably informed as to the progress of its launch, manufacturing and commercialization activities relating to the Product in the
Territory, by way of updates to the JSC at its meetings and as otherwise reasonably requested by XenoPort. It is understood and agreed that, subject to oversight by the JSC, and consistent with the other provisions of this Agreement, all
commercialization and manufacturing efforts for the Product in the Territory shall be at the sole discretion and expense of Astellas, its Affiliates or Subdistributors. 
 5.1.2 XenoPort or its licensee(s) shall be responsible for launching, manufacturing and commercializing the Product outside the Territory. XenoPort shall keep Astellas reasonably informed as to the
progress of its and/or [... * ...] its other licensees’ launch, manufacturing and commercialization activities relating to Product outside the Territory, by way of updates to the JSC at its meetings and as otherwise reasonably
requested by Astellas but no more often than once annually other than at the JSC meeting. It is understood and agreed that all manufacturing and commercialization efforts for the Product outside the Territory shall be at the sole discretion and
expense of XenoPort, its Affiliates or its other licensees. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 5.2 Marketing Materials. Any marketing and promotional materials created or used by
Astellas, its Affiliates and Subdistributors for the Product shall be appropriate to the Marketing Approval for the Product in the respective country and consistent with XenoPort’s worldwide profile for the Product, provided that XenoPort shall
respect local marketing needs in the Territory regarding such materials (e.g., the size of letters in such materials). In addition, it is understood that any claim, message or other material part of promotional materials, samples, advertising and
materials for training sales representatives with respect to Product shall be consistent with Marketing Approval and comply with applicable laws. 
 5.3 Reporting Adverse Drug Reactions/Experiences. Promptly following the Effective Date, the Parties will prepare a standard operating procedure governing the collection, investigation, reporting
and exchange of information concerning adverse drug reactions, Product quality and Product complaints, sufficient to permit each Party to comply with its legal obligations. The standard operating procedure will be promptly updated if required by
changes in legal requirements. Each Party shall keep the other Party informed about any adverse drug reactions of which such Party becomes aware or is informed regarding the use of a Product in or outside the Territory. As between the Parties,
Astellas shall be responsible for reporting all adverse drug reactions/experiences to the appropriate regulatory authorities in countries in the Territory, and XenoPort shall be responsible for reporting all adverse drug reactions/experiences to the
appropriate regulatory authorities in countries outside the Territory, in accordance with the appropriate laws and regulations of the relevant countries and authorities. Astellas shall ensure that its Affiliates and Subdistributors comply with such
reporting obligations in the Territory, and XenoPort shall ensure that its Affiliates and licensees (other than Astellas, its Affiliates and Subdistributors) comply with such reporting obligations outside the Territory. These reporting obligations
shall apply to non-serious adverse events as well, which shall mean adverse events occurring from Product overdose or from Product withdrawal, as well as any toxicity, sensitivity, failure of expected pharmacological action or laboratory abnormality
that is, or is thought by the reporter to be, serious or associated with relevant clinical signs or symptoms. Each Party will designate a regulatory affairs liaison to be responsible for communicating with the other Party regarding the reporting of
adverse drug reactions/experiences. The details of such exchange shall be separately discussed and agreed upon in writing by and between such regulatory affairs liaisons within a reasonable period after execution of this Agreement. 
 6. INITIAL PAYMENT AND MILESTONES 
 6.1 Initial Payment. In partial consideration of the costs incurred by XenoPort in connection with the research and development of the Product and in exchange for the exclusive rights granted
herein, Astellas shall pay XenoPort Twenty Five Million Dollars (US $25,000,000) within [... * ...] after execution of this Agreement. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 6.2 Milestones. In further consideration of the costs incurred by XenoPort in
connection with the research and development of the Product and in exchange for the exclusive rights granted herein: 
 6.2.1
Initiation of U.S. Phase III Trial. Upon the first dosing of a human patient in a Phase III Trial of the Compound and/or Product in the United States by or under authority of XenoPort, the date of which XenoPort shall inform Astellas in
writing, Astellas shall pay XenoPort Ten Million Dollars (US $10,000,000). 
 6.2.2 Completion of U.S. Phase III Trial.
Upon the first completion of a Phase III trial of the Compound and/or Product in the United States by or under authority of XenoPort, Astellas shall pay XenoPort Five Million Dollars (US $5,000,000). As used herein, “completion” of a Phase
III trial shall be deemed to occur upon the earliest of (a) receipt by XenoPort of the final report for such Phase III trial, (b) filing of an MAA for the Product or (c) first issuance of a press release by XenoPort or its licensee
announcing completion of a Phase III trial of the Compound and/or Product in the United States, the date of which XenoPort shall inform Astellas in writing. 
 6.2.3 MAA Filing in the United States. Upon first acceptance of a filing of an MAA for the Compound and/or Product in the United States by or under authority of XenoPort, the date of which XenoPort
shall inform Astellas in writing, Astellas shall pay XenoPort Three Million Dollars (US $3,000,000). As used herein, an MAA shall be deemed “accepted” upon the earlier of: (a) the expiration of the period specified in applicable
regulations for any notice by the FDA that such MAA will not be accepted for review, without XenoPort or its designee having received such notice from such agency; or (b) the receipt by XenoPort or its designee from such agency that the MAA
will be accepted for review; provided that in any case, if no such period or acceptance is provided for in the applicable regulations, then the MAA shall be deemed “accepted” on the date such MAA was filed. 
 6.2.4 MAA Filing in Japan. Upon first acceptance of a filing of an MAA for the Compound and/or Product in Japan by or under
authority of Astellas, Astellas shall pay XenoPort [... * ...]. 
 6.2.5 Marketing Approval in the United
States. Upon obtaining the first Marketing Approval of the Compound and/or Product for the first indication in the United States by or under authority of XenoPort, the date of which XenoPort shall inform Astellas in writing, Astellas shall pay
XenoPort [... * ...]. 
 6.2.6 Marketing Approval in Japan. Upon obtaining the first Marketing Approval of
the Compound and/or Product in Japan for the first indication by or under authority of Astellas, Astellas shall pay XenoPort [... * ...]. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 6.2.7 Additional Indications. 
 (a) Second Indication. Upon first acceptance of a filing of an MAA for the Compound and/or Product for a second indication in Japan
by or under authority of Astellas, Astellas shall pay XenoPort [... * ...]. Upon obtaining the first Marketing Approval of the Compound and/or Product for a second indication in Japan by or under authority of Astellas, Astellas shall
pay XenoPort [... * ...]. As used herein, a “second indication” shall mean any indication for which Marketing Approval is obtained, other than the indication triggering payment under Section 6.2.6 above. 
 (b) Third Indication. Upon first acceptance of a filing of an MAA for the Compound and/or Product for a third indication in Japan by
or under authority of Astellas, Astellas shall pay XenoPort [... * ...]. Upon obtaining the first Marketing Approval of the Compound and/or Product for a third indication in Japan by or under authority of Astellas, Astellas shall pay
XenoPort [... * ...]. As used herein, a “third indication” shall mean any indication for which Marketing Approval is obtained, other than the indications triggering payment under Section 6.2.6 and 6.2.7(a) above.

 (c) Subsequent Indications. Astellas shall not be obligated to make any milestone payments with respect to Marketing
Approval for the fourth and subsequent indications of the Compound and/or Product. It is understood that, for purposes of this Section 6.2.7, a single MAA or Marketing Approval may include more than one indication, e.g. both the first and
second indications, or the second and third indications, as the case may be. 
 6.2.8 Timing of Payment. Each payment
provided in Sections 6.2.4, 6.2.6 and 6.2.7 above shall be due within thirty (30) days following the occurrence of each event triggering such payment, and each payment provided in Sections 6.2.1, 6.2.2, 6.2.3 and 6.2.5 shall be due within
thirty (30) days following XenoPort’s notice to Astellas of the event triggering such payment. 
 7. ROYALTY

 7.1 Royalty. In further consideration for the exclusive rights granted herein, during the term of this Agreement,
Astellas shall, subject to the reduction of royalty rate pursuant to Section 7.3 below, pay to XenoPort the royalties as calculated in this Section 7.1 (as determined below, the “Royalty Rate”) on the Net Sales of the
Product in the Territory. Such Royalty Rate shall be determined [... * ...]. The Royalty Rate to be applied to Annual Net Sales shall be calculated as follows: 
 [... * ...] 
  

  

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MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 For illustrative purposes only: 
 [... * ...] 
 For the
sake of clarity, subject to Section 7.3: (i) in no event will [... * ...]; and (ii) [... * ...]. 
 As
used herein, “Annual Net Sales” of the Product shall mean the Net Sales of Product(s) sold in the Territory by or under authority of Astellas in each calendar year. 
 In the event that the Product [... * ...], for the purposes of determining royalty payments, shall be [... * ...]. In the event that
 [... * ...], such agreement
not to be unreasonably withheld or delayed. This paragraph shall apply to both this Section 7.1 and Section 7.1.1 below. 
 7.1.1 Non-Japanese Marketing Approval. In the event that the Product receives Marketing Approval in one or more countries in the Territory before receiving Marketing Approval in Japan, Astellas shall, subject to the reduction of
royalty rate pursuant to Section 7.3 below, pay to XenoPort the following running royalties on the Net Sales of the Product in the Territory until the Product receives Marketing Approval in Japan: 
  

			
	Annual Net Sales in the Territory	  	Royalty
	That portion of Annual Net Sales in the Territory up to and including [... *
...]	  	[... * ...] of such Net Sales
	That portion of Annual Net Sales in the Territory above
[... * ...] and up to and including [... * ...]	  	[... * ...] of such Net Sales
	That portion of Annual Net Sales in the Territory above
[... * ...]	  	[... * ...] of such Net Sales

 7.1.2 If the Product subsequently does receive Marketing Approval in Japan, upon
such Marketing Approval in Japan, the Royalty Rate calculation as set forth in Section 7.1 shall apply in lieu of Section 7.1.1. 
 7.2 Intentionally Omitted. 
  

  

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PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 7.3 Certain Reductions to Royalties. 
 7.3.1 Third Party Royalties. In the event Astellas or its Affiliates is required to pay to a Third Party royalties or any other
amounts under agreements for patent rights, trade secrets or other intellectual property or technology covering the Compound and/or Product (“Third Party Royalties”), then Astellas may deduct [... * ...] of the
Third Party Royalties from those royalties owed to XenoPort pursuant to Section 7.1; provided the royalties paid to XenoPort will not be so reduced to less than [... * ...] of the royalties otherwise due pursuant Section 7.1,
and further provided that neither Sections 7.3.2 nor 7.3.3 applies at the time. For the purposes of Section 7.1 and this Section 7.3, any Third Party royalties or any other amounts under agreements for patent rights, trade secrets or other
intellectual property or technology covering the Compound and/or Product required to be paid by Astellas or its Affiliates [... * ...]. 
 7.3.2 Loss of Exclusivity. On a Product-by-Product and country-by-country basis, after the later of the expiration of (or if there are no) (a) XenoPort Patent Rights or patent rights
Controlled by Astellas containing Valid Claims, which absent a license thereunder, would be infringed by a Third Party selling such Product in such country and/or (b) regulatory exclusivity with respect to such Product, in such country, then
the royalties payable pursuant to Section 7.1 with respect to such Product sold in such country shall thereafter be reduced by [... * ...], provided that Section 7.3.3 below does not apply at the time. For avoidance of doubt,
clause (a) above shall be deemed satisfied when all the patents described in subparagraph (i) below are expired even if any of the patents described in subparagraph (ii) below are unexpired at that time, as applied on a
Product-by-Product and country-by-country basis (i.e., with respect to the Net Sales of such particular Product in such particular country): 
 (i) in the event of expiration of the patents included in XenoPort Patent Rights or patent rights Controlled by Astellas containing Valid Claims, which absent a license thereunder, would be infringed by a
Third Party selling such Product in such country, or if there are no such patent rights in such country, even if 
 (ii) there
are unexpired patents included in XenoPort Patent Rights or patent rights Controlled by Astellas containing Valid Claims, which absent a license thereunder, would NOT be infringed by a Third Party selling such Product in such country. 
 7.3.3 Introduction of Generic Products. On a Product-by-Product and country-by-country basis, in the event that after the occurrence
of both clause (a) and (b) of Section 7.3.2 above, one or more Generic Product(s) are being marketed for an approved indication of such Product in such country; and such Generic Product(s) represent a total number of units of at
least [... * ...] of such Product and such Generic Product(s) for all indications, in the aggregate, in such country in any calendar year, determined by the number of units of such Product and such Generic Product(s) sold to Third
Parties, in the aggregate, during such calendar year (as measured by IMS data or other data agreed upon by the Parties), and Astellas reasonably determines that Astellas is not likely to recover such lost market share; then the royalties payable
pursuant to Section 7.1 with respect to such Product sold in such country shall thereafter be reduced by [... * ...]. “Generic Product” shall mean a [... * ...] being sold in such country in the
Territory, which [... * ...], and is [... * ...]. 
  

  

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PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 7.3.4 Reductions Not Cumulative. The reductions set forth in this Section 7.3
shall not be cumulative. Notwithstanding anything to the contrary in this Section 7.3, at any time, at most one of Sections 7.3.1, 7.3.2 or 7.3.3 shall apply with respect to any Product in any country. Unless Section 7.3.3 applies, the
royalty payable under this Section 7 shall not be reduced by this Section 7.3 below [... * ...] of the royalties otherwise due pursuant only to Section 7.1 (i.e., without taking into account any of this
Section 7.3). In case Section 7.3.3 applies, the royalties payable under this Section 7 shall not be reduced by this Section 7.3 to below [... * ...] of the royalties otherwise due pursuant to Section 7.1
(i.e., without taking into account any of this Section 7.3). In case Sections 7.3.1 and 7.3.2 apply simultaneously, only Section 7.3.2 shall apply, and in case all three of Sections 7.3.1, 7.3.2 and 7.3.3 apply simultaneously, only
Section 7.3.3 shall apply. 
 7.4 Discounting. Astellas, its Affiliates and Subdistributors shall set prices
and discounts for the Product in the Territory solely in the interest of the commercial success of the Product in the Territory and not for the interest of its other products and services. However, the foregoing shall not be construed to dictate to
Astellas, its Affiliates or Subdistributors any resale prices for the Products in the Territory. 
 7.5 Quarterly
Reports. Commencing with the first occurrence of Net Sales of Product in the Territory, within sixty (60) days after each March 31, June 30, September 30 and December 31 thereafter, Astellas shall deliver to
XenoPort a true and accurate report, giving such particulars of the business conducted by Astellas, its Affiliates and its Subdistributors during the preceding three (3) calendar months as are pertinent to account for payments under this
Section 7. Simultaneously with the delivery of each such report, Astellas shall pay to XenoPort the total amounts, if any, due to XenoPort pursuant to this Section 7 for the period of such report. 
 8. COMPOUND/PRODUCT SUPPLY 
 8.1 Manufacturing and Supply Responsibilities. Contemporaneously with the execution of the Restated License Agreement, the Amended and Restated Non-Commercial Supply Agreement, dated as of
May 15, 2009, by and between the Parties, shall terminate and no longer be in effect. Upon the Restatement Effective Date, subject to the terms and conditions of this Agreement, Astellas shall have the exclusive right and responsibility to
manufacture or have manufactured (including packaging) the Compound, the Material and the Products for both clinical use and commercial distribution in the Territory; except that [... * ...] the Compound, the Material and the Products
[... * ...] the Territory [... * ...]. For the avoidance of doubt, it is understood and agreed that: (i) Astellas shall [... * ...]; (ii) XenoPort shall have no obligation to: (A) [... *
...]; (B) [... * ...]; or (C) [... * ...]; (iii) Astellas shall [... * ...]; and (iv) [... * ...] with respect to the manufacture of the Compound and Products for
distribution [... * ...]. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 8.2 Recalls. To the extent (a) any governmental or regulatory authority issues a
request, directive or order that the Product be recalled or withdrawn in the Territory, (b) a court of competent jurisdiction orders a recall or withdrawal of the Product in the Territory or (c) either Party determines, after consultation
with the other Party, that the Product should be recalled or withdrawn in the Territory, the Parties shall recall or withdraw the Product as set forth in this Section 8.2. As between the Parties, Astellas shall control and coordinate, including
making all contacts with regulatory authorities, all activities it deems necessary in connection with such recall or withdrawal in the Territory. All out-of-pocket expenses related to the execution of any recall or withdrawal of the Product
(“Recall Costs”) shall be shared equally between the Parties, provided that in the case of (c) above, if the Parties do not mutually agree on having the Product recalled or withdrawn, then the Party requesting the recall or
withdrawal shall bear initially the entire expense of such recall or withdrawal; but in each case subject to the final allocation between the Parties as follows. In the event that it is finally determined, or agreed between the Parties, that such
recall or withdrawal is caused by: (a) breach of the representations and warranties of XenoPort set forth in Section 13.2 below, or the gross negligence or willful misconduct of XenoPort, or the failure by XenoPort to comply with
applicable laws and regulations (collectively, the “Fault of XenoPort”) XenoPort shall be responsible for Recall Costs to extent of such Fault of XenoPort, (b) the failure of Astellas to properly perform the manufacturing,
formulation or packaging of the Compound and/or Products, or the gross negligence or willful misconduct of Astellas, or the failure by Astellas to comply with applicable laws and regulations, including its failure to properly file for Marketing
Approval of the Products in the Territory (collectively, the “Fault of Astellas”), Astellas shall be responsible for Recall Costs to the extent of such Fault of Astellas and (c) in all other cases, the Recall Costs shall be
shared by the Parties as follows: [... * ...] shall be borne by Astellas and [... * ...] shall be borne by XenoPort. 
 9. PAYMENTS; BOOKS AND RECORDS 
 9.1 Payment Method. All
payments under this Agreement shall be made by bank wire transfer in immediately available funds to an account designated by the Party to which such payments are due. All dollar amounts specified in this Agreement are in U.S. dollars. Any payments
due under this Agreement that are not paid by the date such payments are due under this Agreement shall bear interest to the extent permitted by applicable law at the prime rate publicly announced by Citibank on the date such payment is due, plus
[... * ...], computed on the basis of a three hundred sixty (360) day year, actual days elapsed. The applicable interest rate shall be adjusted each time there shall be a change in the prime rate announced by Citibank. This
Section 9.1 shall in no way limit any other remedies available to the Parties. All amounts owed by Astellas to XenoPort hereunder shall be paid by a Japanese entity from either a bank account in Japan or the United States. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 9.2 Taxes. If laws or regulations require withholding by Astellas of any taxes
imposed upon XenoPort on account of any royalties, initial or milestone payments paid under this Agreement, such taxes shall be deducted by Astellas as required by law from such payment and shall be paid by Astellas to the proper taxing authorities.
Official receipts of payment of any withholding tax shall be secured and sent to XenoPort as evidence of such payment. The Parties will exercise their reasonable efforts to ensure that any withholding taxes imposed are reduced as far as possible
under the provisions of any applicable tax treaty, and shall cooperate in filing any forms required for such reduction. Both Parties agree that under the applicable tax treaty as of the Effective Date, no withholding taxes are due on any amounts due
hereunder provided that the appropriate forms have been filed with the tax authorities in Japan. 
 9.3 U. S.
Dollars. All sums due under this Agreement shall be payable in U.S. dollars. Monetary conversion from the currency of a foreign country, in which Product is sold, into United States currency shall be calculated at the actual average of the
buying and selling rates of exchange for a calendar quarter in which such sales were made as such rates are reported, as of the last business day of such calendar quarter, by Bank of Tokyo-Mitsubishi. 
 9.4 Records; Inspection.
 9.4.1 Astellas. Astellas shall keep, and require its Affiliates and Subdistributors to keep, complete, true and accurate books of accounts and records for the purpose of determining the amounts
payable to XenoPort pursuant to this Agreement. Such books and records shall be kept for at least three (3) years following the end of the calendar quarter to which they pertain. Such records will be open for inspection during such three
(3) year period by an independent auditor chosen by XenoPort and reasonably acceptable to Astellas for the purpose of verifying the amounts payable by Astellas hereunder. Such inspections may be made no more than once each calendar year, at
reasonable times and on reasonable prior written notice. Such records for any particular calendar quarter shall be subject to no more than one inspection. The independent auditor shall be obligated to execute a reasonable confidentiality agreement
prior to commencing any such inspection. Inspections conducted under this Section 9.4.1 shall be at the expense of XenoPort, unless a variation or error producing an underpayment in amounts payable exceeding [... * ...] of the
amount paid for any period covered by the inspection is established in the course of any such inspection, whereupon all costs relating to the inspection for such period and any unpaid amounts that are discovered shall be paid by Astellas, together
with interest on such unpaid amounts at the rate set forth in Section 9.1 above. The Parties will endeavor in such inspection to minimize disruption of Astellas’ normal business activities to the extent reasonably practicable. 

9.4.2 XenoPort. XenoPort shall keep complete, true and accurate books of accounts and records for the purpose of determining
payments due from Astellas pursuant to this Agreement. Such books and records shall be kept for at least three (3) years following the end of the calendar quarter to which they pertain. Such records will be open for inspection during such three
(3) year period by an independent auditor chosen by Astellas and reasonably acceptable to XenoPort for the purpose of verifying the amounts

  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 
payable by Astellas hereunder. Such inspections may be made no more than once each calendar year, at reasonable times and on reasonable prior written notice. Such records for any particular
calendar quarter shall be subject to no more than one inspection. Astellas’ independent auditor shall be obligated to execute a reasonable confidentiality agreement prior to commencing any such inspection. Inspections conducted under this
Section 9.4.2 shall be at the expense of Astellas, unless a variation or error producing an overpayment in amounts payable exceeding [... * ...] of the amount paid for any period covered by the inspection is established in the
course of any such inspection, whereupon all costs relating to the inspection for such period and any overpaid amounts that are discovered shall be paid by XenoPort, together with interest on such overpaid amounts at the rate set forth in
Section 9.1 above. The Parties will endeavor in such inspection to minimize disruption of XenoPort’s normal business activities to the extent reasonably practicable. 
 10. INTELLECTUAL PROPERTY 
 10.1 Ownership of Inventions. Title to all inventions and other intellectual property made solely by Astellas personnel in connection with this Agreement shall be owned by Astellas. Title to
all inventions and other intellectual property made solely by XenoPort personnel in connection with this Agreement shall be owned by XenoPort. Title to all inventions and other intellectual property made jointly by personnel of XenoPort and Astellas
in connection with this Agreement shall be jointly owned by Astellas and XenoPort. Prosecution of any patent applications and patents with respect to such jointly owned inventions and intellectual property shall be solely as mutually agreed. Except
as expressly provided in this Agreement, it is understood that neither Party shall have any obligation to obtain any approval of nor pay a share of the proceeds to the other Party to exploit or enforce such jointly owned inventions or intellectual
property, and that neither Party shall, without obtaining the approval of the other Party, license or assign the same to a Third Party other than its licensees of (or an assignee of all or substantially all of its assets or business in any country
pertaining to) the Compound and/or the Product or Subdistributors. For clarity, each Party shall have the right, without having to obtain the approval of, nor to pay a share of the proceeds to, the other Party, to license and/or assign such jointly
owned intellectual property to any licensee of the Compound and/or Product or Subdistributor or to an assignee of all or substantially all of its assets or business pertaining to the Compound and/or Product in any country. Astellas hereby grants to
XenoPort a non-exclusive, worldwide, irrevocable, fully paid-up license, with the right to sublicense, under any Improvements to make, have made, use, sell, offer for sale, import, practice and otherwise exploit the same for the Compound and/or the
Product, subject to the exclusive rights granted to Astellas under this Agreement with respect to the Product in the Territory. As used herein, “Improvements” means any patent rights or other intellectual property made by or under
authority of Astellas in connection with manufacturing, developing and/or commercializing the Product that is applicable to the Compound, Product or transported prodrugs thereof or the manufacture, use or formulation thereof. Notwithstanding
anything to the contrary contained herein, subject to Section 2.7 of the GSK Agreement, XenoPort shall not have the right to sublicense or disclose to GSK any Astellas Manufacturing Know-How and/or Improvements relating to manufacturing the
Compound, the Material and/or the Product inside or outside the Territory until the expiration or earlier termination of this Agreement in all countries of the Territory pursuant to Section 15.2 or 15.3 below or Section 2.4 above.

  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 10.2 Prosecution and Maintenance of Patents. 
 10.2.1 Filings. As between Astellas and XenoPort, XenoPort shall have responsibility for the filing, prosecution and maintenance of
all XenoPort Patent Rights in the Territory at XenoPort’ expense. Astellas shall have the right to review pending patent applications and make recommendations to XenoPort concerning the foregoing. XenoPort will consider in good faith all
reasonable suggestions of Astellas with respect thereto. XenoPort agrees to keep Astellas generally informed of the course of patent prosecution or other proceedings with respect to the XenoPort Patent Rights within the Territory, including those
patents and patent applications relating to the Compound and/or the Product in the Territory which shall not be listed in Exhibit B as of the Effective Date. 
 10.2.2 Extensions. XenoPort shall, [... * ...], file for extensions of the terms of any and all of the XenoPort Patent Rights if legally possible in any country of the Territory with
respect to the Product and shall be responsible for prosecuting any required actions for such extensions at its own expense. 
 10.3 Third Party Infringement Claims. If the production, sale or use of any Compound or Product in the Territory pursuant to this Agreement results in a claim, suit or proceeding alleging patent infringement against XenoPort or
Astellas (or their respective Affiliates or Subdistributors) (collectively, “Infringement Actions”), such Party shall promptly notify the other Party hereto in writing. The Party subject to such Infringement Action shall have the
right to direct and control the defense thereof (including the conclusion of a potential settlement, but limited to the rights granted pursuant to this Agreement) using counsel reasonably acceptable to the other Party, and the Infringement Action
shall be at the expense of the Party subject to such Infringement Action; provided, however, that the other Party may participate in the defense and/or settlement thereof at its own expense with counsel of its choice. In any event, the Party that is
subject to the Infringement Action agrees to keep the other Party hereto reasonably informed of all material developments in connection with any such Infringement Action. Astellas agrees not to settle any Infringement Action, or make any admissions
or assert any position in such Infringement Action, in a manner that would adversely affect the Product or the manufacture, use or sale thereof in or outside the Territory, without the prior written consent of XenoPort. XenoPort agrees not to settle
any Infringement Action in a manner that would adversely affect the Product or the manufacture, use or sale thereof in the Territory, without the prior written consent of Astellas. Astellas may treat its Damages from such Infringement Action as
Third Party Royalties under Section 7.3.1 above, and XenoPort may treat its Damages from such Infringement Action as payments for Third Party IP under Section 2.5 above. As used herein, “Damages” shall mean out-of-pocket
costs incurred by a Party, including reasonable attorney’s fees, damages and other liabilities that are part of any final judgment awarded against such Party, and any amounts paid by such Party in a settlement of the action that is approved by
the other Party, such approval not to be unreasonably withheld or delayed. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 10.4 Enforcement. Subject to the provisions of this Section 10.4, in the
event that Astellas reasonably believes that any XenoPort Patent Rights in the Territory is infringed or misappropriated by a third party or is subject to a declaratory judgment action in the Territory arising from such infringement, in each case
with respect to the manufacture, sale or use within the Field in the Territory of a product comprising a prodrug of gabapentin (an “Infringing Product”), Astellas shall promptly notify XenoPort. XenoPort shall have the initial right
(but not the obligation), at its own expense, to enforce the XenoPort Patent Rights with respect to such infringement or defend any declaratory judgment action with respect thereto in the Territory (for purposes of this Section 10.4, an
“Enforcement Action”). Astellas shall, at its expense, have the right to join in as a party plaintiff and to give reasonable assistance to such Enforcement Action. XenoPort shall keep Astellas reasonably informed of the progress of
any such Enforcement Action. XenoPort agrees not to settle any Enforcement Action, or make any admissions or assert any position in such Enforcement Action, in a manner that would materially adversely affect Astellas’ rights or interests in the
Territory, without the prior written consent of Astellas, which shall not be unreasonably withheld or delayed. 
 10.4.1
Initiating Enforcement Actions. In the event that XenoPort fails to initiate an Enforcement Action to enforce the XenoPort Patent Rights against a commercially significant infringement by a third party in a country in the Territory, which
infringement consists of the manufacture, sale or use of an Infringing Product in the Field in such country, within [... * ...] of a request by Astellas to initiate such Enforcement Action, Astellas may initiate an Enforcement Action
against such infringement at its own expense. Upon [... * ...], provided that [... * ...]. Astellas shall keep XenoPort reasonably informed of the progress of any such Enforcement Action. XenoPort shall, at its expense,
have the right to join in as a party plaintiff and to give reasonable assistance to such Enforcement Action. Astellas agrees not to settle any Enforcement Action, or make any admissions or assert any position in such Enforcement Action, in a manner
that would materially adversely affect the validity, enforceability or scope of the XenoPort Patent Rights in or outside the Territory, without the prior written consent of XenoPort, which shall not be unreasonably withheld or delayed. 

10.4.2 Recoveries. Any damages or other monetary awards recovered from an Enforcement Action shall be allocated first to
reimburse the costs and expenses of Party who initiates the Enforcement Action and, if the other Party joins as a party plaintiff, then the costs and expenses of the other Party. Any amounts remaining shall be shared [... * ...] to
Astellas and
 [... * ...] to XenoPort. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 10.5 Third Party Rights. The obligations of XenoPort and the rights of Astellas
under Sections 10.2 and 10.4 above shall be subject to, and limited by, any agreements pursuant to which XenoPort acquired or licensed any particular XenoPort Patent Rights, Data or other subject matter. With respect to the prosecution or
enforcement of XenoPort Patent Rights licensed by XenoPort from a Third Party, to the extent XenoPort has the right to do so, XenoPort shall cooperate with Astellas to prosecute and enforce such XenoPort Patent Rights in the same manner as set forth
in Sections 10.2 and 10.4 above. As between XenoPort and Astellas, any recoveries from enforcement of such XenoPort Patent Rights licensed from a Third Party (including any amounts that XenoPort receives from the Third Party licensor as a result of
such enforcement) shall be shared in accordance with Sections 10.4.2, after deducting from such recoveries any amounts owed to the Third Party licensor for such enforcement; provided that any Enforcement Actions initiated by the Third Party licensor
shall be deemed initiated by XenoPort for purposes of Section 10.4.2 above, and the costs and expenses incurred by XenoPort in such Enforcement Action shall include the costs and expenses reimbursed or required to be reimbursed by XenoPort to
the Third Party licensor in such Enforcement Action. 
 10.6 Patent Marking. Astellas agrees to mark and have its
Affiliates and Subdistributors mark all patented Products they sell or distribute pursuant to this Agreement in accordance with the applicable patent statutes or regulations in the country or countries of manufacture and sale thereof. 
 11. TRADEMARKS 
 11.1 Display. All packaging materials, labels and promotional materials for the Product in the Territory shall display the Product Trademark to the extent such packaging materials, labels and
promotional materials have enough space for such display. Astellas shall include in its packaging materials, labels and promotional materials a statement, of reasonable size and prominence approved by XenoPort, acknowledging that the Product is sold
under license from XenoPort to the extent such packaging materials, labels and promotional materials have enough space for such statement. The Astellas trade dress and style of packaging with respect to each Product may be determined by Astellas so
as to be consistent with Astellas’ standard trade dress and style, but shall, so far as is reasonable, be consistent with XenoPort’s worldwide branding strategy for the Product, provided that XenoPort shall respect local marketing needs in
the Territory regarding trade dress and style. 
 11.2 License. XenoPort hereby grants to Astellas an exclusive
(even as to XenoPort), royalty-free license to use the Product Trademark solely in connection with formulation, packaging, marketing, promoting, distributing and selling the Product in the Territory in accordance with this Agreement. The ownership
and all goodwill from the use of the Product Trademark shall vest in and inure to the benefit of XenoPort. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 11.3 Registration. XenoPort agrees to file, register and be responsible to
maintain a registration for the Product Trademark in Japan (and in countries of the Territory outside Japan, upon notice from Astellas that an MAA for the Product is being filed in such country), for the term of this Agreement, for use with the
Product. The costs of filing and maintaining such registrations in the Territory shall be borne by XenoPort. 
 11.4
Ownership. Astellas hereby acknowledges XenoPort’s exclusive ownership rights in the Product Trademark, and accordingly agrees that at no time during the term of this Agreement or for [... * ...] thereafter to challenge or
assist others to challenge the Product Trademark or the registration thereof, nor during the term of this Agreement to attempt to register any trademarks, marks or trade names confusingly similar to such Product Trademark. 
 11.5 Recordation. In those countries where a trademark license must be recorded, XenoPort will provide and record a separate
trademark license for the Product Trademark, at XenoPort’s sole expense. Astellas shall cooperate in the preparation and execution of such documents. 
 11.6 Approval of Promotional Materials. Astellas shall submit representative samples of promotional materials, packaging and Product using the Product Trademark to XenoPort for XenoPort’s
reasonable approval, which approval shall not be unreasonably withheld or delayed, prior to their first use and prior to any subsequent change or addition to such promotional materials, provided that if XenoPort has not responded within four
(4) weeks after receiving such submissions, XenoPort’s approval will be deemed to have been received. 
 11.7
Termination. Astellas’ right to use the Product Trademark shall terminate in each country of the Territory in which Astellas’ rights to distribute the Product are terminated in accordance with this Agreement. Astellas shall
cooperate in the cancellation of any trademark licenses recorded or entered into in such countries. 
 12.
CONFIDENTIALITY 
 12.1 Confidential Information. Except as expressly provided in this Agreement, the
Parties agree that the receiving Party shall not publish or otherwise disclose and shall not use for any purpose any information furnished to it by the other Party hereto pursuant to this Agreement (collectively, “Confidential
Information”). Notwithstanding the foregoing, Confidential Information shall not include information that, in each case as demonstrated by written documentation: 
 12.1.1 was already known to the receiving Party, other than under an obligation of confidentiality, at the time of disclosure or, as shown
by written documentation, was developed by the receiving Party independent of disclosure by the disclosing Party; 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 12.1.2 was generally available to the public or otherwise part of the public domain at the
time of its disclosure to the receiving Party; 
 12.1.3 became generally available to the public or otherwise part of the
public domain after its disclosure and other than through any act or omission of the receiving Party in breach of this Agreement; 
 12.1.4 was subsequently lawfully disclosed to the receiving Party by a person other than the disclosing Party, and who did not directly or indirectly receive such information from disclosing Party; or 
 12.1.5 is developed by the receiving Party without use of or reference to any information or materials disclosed by the disclosing Party.

 12.2 Permitted Disclosures. Notwithstanding the provisions of Section 12.1 above, each Party hereto may
disclose the other Party’s Confidential Information to its Affiliates, licensees, Subdistributors and any other Third Parties to the extent such disclosure is reasonably necessary to exercise the rights granted to it, or reserved by it, under
this Agreement (including the right to grant sublicenses, as applicable), prosecuting or defending litigation, complying with applicable governmental laws or regulations, submitting information to tax or other governmental authorities or conducting
clinical trials hereunder with respect to the Product. If a Party is required by law or regulations to make any such disclosure of the other Party’s Confidential Information, to the extent it may legally do so, it will give reasonable advance
notice to the latter Party of such disclosure and, save to the extent inappropriate in the case of patent applications or otherwise, will use its good faith efforts to secure confidential treatment of such Confidential Information prior to its
disclosure (whether through protective orders or otherwise). For any other disclosures of the other Party’s Confidential Information, including to Affiliates, licensees, Subdistributors and other Third Parties, a Party shall ensure that the
recipient thereof is bound by a written confidentiality agreement as materially protective of such Confidential Information as this Section 12. If the Party whose Confidential Information is to be disclosed has not filed a patent application
with respect to such Confidential Information, it may require the other Party to delay the proposed disclosure (to the extent the disclosing Party may legally do so), for up to ninety (90) days, to allow for the filing of such an application.

 12.3 Terms of this Agreement. Each Party agrees [... * ...], except [... * ...] pursuant to
clause (a) above, the [... * ...] 
 12.4 Publicity. Subject to Section 12.3 above, neither
Party shall originate any written publicity, news release or other announcement or statement relating to this Agreement (collectively, a “Written Disclosure”), without the prompt prior review and written approval of the other Party,
which approval shall not be unreasonably withheld or delayed. Notwithstanding the foregoing,

  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 
either Party may make any public Written Disclosure it believes in good faith based upon the advice of counsel is required by applicable law, rule or regulation or any listing or trading
agreement concerning its or its Affiliates’ publicly traded securities. In addition, the Parties shall agree upon a press release to announce the execution of this Agreement, together with a corresponding Question & Answer outline for
use in responding to inquiries about the Agreement; thereafter, Astellas and XenoPort may each disclose to third parties the information contained in such press release and Question & Answer outline without the need for further approval by
the other. 
 12.5 Prior Non-Disclosure Agreements. Upon execution of this Agreement, the terms of this
Section 12 shall supersede any prior non-disclosure, secrecy or confidentiality agreement between the Parties. Any information disclosed under such prior agreements shall be deemed disclosed under this Agreement. 
 12.6 Publication of Product Information. Prior to publishing, publicly presenting and/or submitting for written or oral
publication a manuscript, abstract or the like that includes Data or other information relating to Product that has not previously published pursuant to this Section 12.6, a Party shall provide the other Party a copy thereof in English for its
review for at least thirty (30) days (unless such Party is required by law to publish such information sooner). Such Party shall consider in good faith any comments provided by the other Party during such thirty (30) day period. In
addition, such Party shall, at the request of the other Party, remove any Confidential Information of the other Party therefrom, except each Party shall have the right to publicly disclose any information, including Confidential Information,
pertaining to safety or efficacy of the Compound and/or Product that such Party believes in good faith it is obligated or appropriate to disclose. The contribution of each Party shall be noted in all publications or presentations by acknowledgment
or coauthorship, whichever is appropriate. 
 13. REPRESENTATIONS AND WARRANTIES 
 13.1 Mutual Warranty. Each Party represents and warrants to the other that this Agreement is a legal and valid obligation binding upon
such Party and enforceable in accordance with its terms. The execution, delivery and performance of this Agreement by such Party does not conflict with any agreement, instrument or understanding, oral or written, to which it is a party or by which
it is bound, nor, to such Party’s knowledge, violate any law or regulation of any court, governmental body or administrative or other agency having jurisdiction over it. 
 13.2 XenoPort Warranties. XenoPort represents and warrants to Astellas that, as of the Effective Date: 
 13.2.1 it has the full right and authority to enter into this Agreement and grant the rights and licenses as provided herein; 

 

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 13.2.2 it has not previously granted any right, license or interest in or to the XenoPort
Patent Rights, or any portion thereof, that is in conflict with the rights or licenses granted to Astellas under this Agreement; 
 13.2.3 XenoPort has not knowingly withheld from Astellas any material information in the possession of XenoPort related to the safety or efficacy of the Compound and/or the Product (a) that has been requested by Astellas, or
(b) that XenoPort considered to be reasonably material to Astellas’ evaluation of the safety and/or efficacy of the Compound and/or Product; 
 13.2.4 XenoPort has not knowingly withheld from Astellas any material CMC Information in the possession of XenoPort regarding the Existing Product (a) that has been requested by Astellas, or
(b) that XenoPort considered to be reasonably material to Astellas’ evaluation of the quality of the Compound and/or Product. As used herein, “CMC Information” means information of the type required to appear in
Section 7.0 of IND Nos. 68,341 and 71,352; 
 13.2.5 to its best knowledge, there are no actual, pending, alleged or
threatened action, suits, claims, interference or governmental investigations involving the Compound and/or the Product, the XenoPort Patent Rights, the XenoPort Know-How or the Product Trademark by or against XenoPort, or any of its Affiliates or
other licensees in or before any court, governmental or regulatory authority. In particular, to its best knowledge, there is no pending or threatened product liability action nor intellectual property right litigation in relation to the Compound
and/or the Product; 
 13.2.6 all necessary consents, approvals and authorizations of all governmental authorities and other
persons or entities required to be obtained by XenoPort in order to enter into this Agreement have been obtained; 
 13.2.7 to
its best knowledge, there are no actual, pending, alleged or threatened infringement by a Third Party of any of the XenoPort Patent Rights or the XenoPort Know-How; 
 13.2.8 to its best knowledge, none of the issued XenoPort Patent Rights are invalid or unenforceable. 
 13.2.9 there are no XenoPort Patent Right that are licensed by XenoPort from any Third Party, which would, but for the license granted hereunder, be infringed by use, development, formulation, packaging,
import, sale, distribution, promotion or marketing of the Compound and/or the Product by Astellas, any of its Affiliates or Subdistributors in accordance with this Agreement. There are no Data licensed by XenoPort from any Third Party relating to
the Compound and/or the Product. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 13.2.10 XenoPort has not granted a lien or other encumbrances on any of the subject matter
of this Agreement or on any of XenoPort’s rights, benefits or obligations hereunder or on any of the XenoPort Patent Rights, which would conflict with the rights or licenses of Astellas hereunder. 
 13.2.11 Notwithstanding the foregoing, it is understood that substantial information has been published in XenoPort’s SEC filings and
in its scientific publications regarding the Compound and/or the Product, and is available to the public. Accordingly, for purposes of this Section 13.2, Astellas shall be deemed to be on notice of and to have received disclosures of such
information, and the representations and warranties set forth in this Section 13.2 shall be subject to such disclosures. 
 13.3 XenoPort Covenants. XenoPort covenants to Astellas that, during the term of this Agreement (a) it shall not grant any right, license or interest in or to the XenoPort Patent Rights, or any portion thereof, that is in
conflict with the rights or licenses granted under this Agreement, and (b) it shall not grant a lien or other encumbrances on any of the subject matter of this Agreement or on any of XenoPort’s rights, benefits or obligations hereunder or
on any of the XenoPort Patent Rights, which would conflict with the rights or licenses of Astellas hereunder. 
 13.4
Astellas Warranties. Astellas represents and warrants to XenoPort that, as of the Effective Date: (a) it has the full right and authority to enter into this Agreement and grant the rights granted herein; (b) Astellas and its
Affiliates have not initiated any human clinical trials with respect to, and are not commercializing, any products containing the Compound or any Competitive Compound, and are not engaged in contract negotiations with respect to in-licensing or
acquiring any specific product or technology relating to the Compound or any Competitive Compound(s); (c) all necessary consents, approvals and authorizations of all governmental authorities and other persons or entities required to be obtained
by Astellas in order to enter into this Agreement have been obtained; and (d) Astellas does not have any knowledge that any of XenoPort’s representations and warranties set forth in Section 13.2 above are inaccurate. 
 13.5 DISCLAIMER. EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN THIS AGREEMENT, NEITHER PARTY MAKES ANY REPRESENTATION OR EXTENDS ANY
WARRANTIES OF ANY KIND EITHER EXPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, NONINFRINGEMENT OR VALIDITY OF ANY PATENTS ISSUED OR PENDING. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 13.6 LIMITATION OF LIABILITY. NOTWITHSTANDING ANYTHING IN THIS AGREEMENT OR
OTHERWISE, NEITHER PARTY SHALL BE LIABLE TO THE OTHER WITH RESPECT TO ANY SUBJECT MATTER OF THIS AGREEMENT, WHETHER UNDER ANY CONTRACT, NEGLIGENCE, STRICT LIABILITY OR OTHER LEGAL OR EQUITABLE THEORY, FOR ANY INCIDENTAL, INDIRECT, SPECIAL,
EXEMPLARY, PUNITIVE, MULTIPLE, OR CONSEQUENTIAL DAMAGES (INCLUDING, WITHOUT LIMITATION, LOST PROFITS, LOSS OF USE, DAMAGE TO GOODWILL, OR LOSS OF BUSINESS) EXCEPT IN THE CASE OF (A) BREACH OF SECTION 2.4.3 BY ASTELLAS OR ITS AFFILIATES,
(B) BREACH OF SECTION 12, (C) SUCH DAMAGES OWED TO THIRD PARTIES PURSUANT TO SECTION 14 OR (D) BREACH OF ASTELLAS’ OBLIGATION TO USE DILIGENT EFFORTS TO DEVELOP AND/OR COMMERCIALIZE THE PRODUCT PURSUANT TO SECTIONS 4.1.1 AND
5.1.1, PROVIDED IT IS UNDERSTOOD THAT IN THE CASE OF (D) DAMAGES SHALL BE CALCULATED BASED ON LOSS OF ROYALTIES AND OTHER AMOUNTS OWED TO XENOPORT HEREUNDER AS A RESULT OF SUCH BREACH, AND NOT BASED ON THE LOSS OF NET SALES RECEIVED BY
ASTELLAS. 
 14. INDEMNIFICATION 
 14.1 Indemnification of XenoPort. Astellas shall indemnify and hold harmless each of XenoPort, its Affiliates and the directors, officers and employees of such entities and the successors and
assigns of any of the foregoing (the “XenoPort Indemnitees”), from and against any and all liabilities, damages, penalties, fines, costs, expenses (including, without limitation, reasonable attorneys’ fees and other expenses of
litigation) (“Liabilities”) from any claims, actions, suits or proceedings brought by a Third Party (a “Third Party Claim”) incurred by any XenoPort Indemnitee, arising from, or occurring as a result of:
(a) the use, marketing, distribution or sale of any Product by Astellas, its Affiliates or Subdistributors in the Territory (and manufacturing, formulation and packaging activities by or under authority of Astellas inside or outside the
Territory pursuant to Section 2.2 or development activities by Astellas or requested by Astellas outside the Territory pursuant to 4.7), including, without limitation, any Products Liability Claim (subject to and shared in accordance with the
mechanism set forth in Section 14.4 below) and Third Party infringement claims (subject to Section 10.3 above), or (b) any material breach of any representations, warranties or covenants by Astellas in Section 13 above; except to
the extent such Third Party Claims fall within the scope of XenoPort’s indemnification obligations set forth in Section 14.2 below. 
 14.2 Indemnification of Astellas. XenoPort shall indemnify and hold harmless each of Astellas, its Affiliates and Subdistributors and the directors, officers and employees of Astellas, its
Affiliates and Subdistributors and the successors and assigns of any of the foregoing (the “Astellas Indemnitees”), from and against any and all Liabilities from any Third Party Claims incurred by any Astellas Indemnitee, arising
from, or occurring as a result of: (a) the use, marketing, distribution or sale of any Product by XenoPort or its licensee outside the Territory (other than manufacturing, formulation and packaging activities by or under authority of Astellas
outside the Territory pursuant to Section 2.2 and development activities by Astellas or requested by Astellas outside the Territory pursuant to 4.7), (b) any material breach of any representations, warranties or covenants by XenoPort in
Section 13 above, or (c) subject to and shared in accordance with the mechanism set forth in Section 14.4 below, any Product Liability Claim asserted against the Astellas Indemnitees. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 14.3 Procedure. Except with respect to Third Party infringement claims subject
to Section 10.3 above, and Product Liability Claims subject to Section 14.4 below, a Party that intends to claim indemnification under this Section 14 (the “Indemnitee”) shall promptly notify the other Party (the
“Indemnitor”) in writing of any Third Party Claim, in respect of which the Indemnitee intends to claim such indemnification, and the Indemnitor shall have sole control of the defense and/or settlement thereof. The indemnity
arrangement in this Section 14 shall not apply to amounts paid in settlement of any action with respect to a Third Party Claim, if such settlement is effected without the consent of the Indemnitor, which consent shall not be withheld or delayed
unreasonably. The failure to deliver written notice to the Indemnitor within a reasonable time after the commencement of any action with respect to a Third Party Claim, if prejudicial to its ability to defend such action, shall relieve such
Indemnitor of any liability to the Indemnitee under this Section 14, but the omission to so deliver written notice to the Indemnitor shall not relieve the Indemnitor of any liability that it may have to any Indemnitee otherwise than under
this Section 14. The Indemnitee under this Section 14 shall cooperate fully with the Indemnitor and its legal representatives in the investigation of any action with respect to a Third Party Claim covered by this indemnification.

 14.4 Products Liability Claims. Each Party shall notify the other Party as promptly as practicable if any Third Party
Claim is commenced or threatened against such Party alleging product liability, product defect, design, manufacturing, packaging or labeling defect, failure to warn, or any similar action relating to the formulation, manufacture, use or safety of
those Products sold by or under authority of Astellas in the Territory hereunder (“Product Liability Claim”). Each Party shall cooperate with the other Party in connection with any such Product Liability Claim that is commenced or
threatened against the other Party. If a Product Liability Claim is asserted against both Parties, each Party will have the right to designate counsel to defend itself in the Product Liability Claim. If a Product Liability Claim is brought against
one Party but not the other Party, the named Party shall control the defense and/or settlement thereof at its own expense with counsel of its choice, subject to this Section 14.4. In such case, the other Party may participate in the defense
and/or settlement thereof at its own expense with counsel of its choice. In any event, the Party that is subject to the Product Liability Claim (if not asserted against both Parties) agrees to keep the other Party hereto reasonably informed of all
material developments in connection with any such Product Liability Claim. Astellas agrees not to settle any Product Liability Claim, or make any admissions or assert any position in such Product Liability Claim, in a manner that would adversely
affect the Product or the manufacture, use or sale thereof in or outside the Territory, without the prior written consent of XenoPort. XenoPort agrees not to settle any Product Liability Claim, or make any admissions or assert any position in such
Product Liability Claim, in a manner that would adversely affect the Product or the manufacture, use or sale thereof in the Territory, without the prior written consent of

  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 
Astellas. To the extent a Product Liability Claim is caused by: (a) the Fault of XenoPort (as defined in Section 8.2 above), XenoPort shall bear all Liabilities from such Product
Liability Claim to the extent of its Fault, (b) the Fault of Astellas (as defined in Section 8.2 above), Astellas shall bear all Liabilities from such Product Liability Claim to the extent of its Fault and (c) neither the Fault of
XenoPort nor the Fault of Astellas, the Parties shall share the Liabilities from such Product Liability Claim as follows: [... * ...] shall be borne by Astellas, and [... * ...] shall be borne by XenoPort. 
 14.5 Insurance. Each Party shall secure and maintain in effect during the term of this Agreement and for a period of [...
* ...] thereafter insurance policy(ies) underwritten by a reputable insurance company in a form and having limits standard and customary for entities in the biopharmaceutical industry for exposures related to the Product. Such policies shall
include coverage for clinical trial liability and products liability. Upon request by the other Party hereto, certificates of insurance evidencing the coverage required above shall be provided to the other Party. 
 15. TERM AND TERMINATION 
 15.1 Term. This Agreement shall become effective as of the Effective Date and, shall continue, on a country-by-country basis, until terminated pursuant to Section 15.2 or 15.3 below or
Section 2.4 above. 
 15.2 Termination By Astellas. Astellas may terminate this Agreement for any reason under
this Section 15.2 without any penalty, consequence, termination compensation, loss of profits, goodwill indemnity or otherwise solely by reason of such termination (i.e., without prejudice to any remedies XenoPort may have for a breach
of this Agreement by Astellas), as a whole or on a country-by-country basis with respect to countries in the Territory upon written notice to XenoPort; provided that such notice is given after the third anniversary of the Effective Date. In the
event Astellas elects to terminate this Agreement under this Section 15.2 with respect to Japan, Astellas shall have elected to terminate this Agreement in whole. Without limiting the other provisions of this Agreement, if, at any time after
the First Commercial Sale of a Product in a country, [... * ...] with respect to such country (if a country in the Territory other than Japan), or as a whole (if such country is Japan); and this Agreement shall so terminate upon such
notice by XenoPort without any penalty, consequence, termination compensation, loss of profits, goodwill indemnity or otherwise solely by reason of such deemed termination. 
 15.3 Termination for Cause. In the event a Party fails to pay any amount due under this Agreement or otherwise materially breaches
any obligation, covenant or warranty under this Agreement, the other Party shall have the right to terminate this Agreement upon written notice, provided that such breach is not cured within [... * ...] (if a failure to pay), or within
[... * ...] (if any other material breach), after notice thereof specifying such breach. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 16. EFFECT OF TERMINATION 
 16.1 Accrued Obligations. Termination of this Agreement for any reason shall not release any Party hereto from any liability that, at
the time of such termination, has already accrued to the other Party or that is attributable to a period prior to such termination nor preclude either Party from pursuing all rights and remedies it may have hereunder or at law or in equity with
respect to any breach of this Agreement. 
 16.2 Rights on Termination. This Section 16.2 shall apply upon any
termination of Astellas’ rights under this Agreement in whole or with respect to a particular country, excluding only termination of this Agreement pursuant to Section 15.3 for XenoPort’s breach. As used herein, the “Affected
Area” shall mean the Territory in case of termination of this Agreement as a whole, or the terminated country(ries) in case of termination of this Agreement with respect to such country(ries). 
 16.2.1 Wind-down Period. 
 (a) Development. In the event there are any on-going clinical trials of the Product in an Affected Area, at XenoPort’s request, Astellas agrees to either promptly transition such clinical
trials to XenoPort, or continue to conduct such clinical trials (i) in the case of termination by XenoPort pursuant to Section 15.3 or 2.4, or termination by Astellas pursuant to Section 15.2, at Astellas’ own expense and
(ii) in the case of any other termination, at XenoPort’s expense for a period requested by XenoPort up to a maximum of [... * ...] after such termination. 
 (b) Commercialization. In case of termination by XenoPort pursuant to Section 15.3 or 2.4, or termination by Astellas pursuant
to Section 15.2, Astellas and its Subdistributors shall continue to distribute Products in each country of the Affected Area for which Marketing Approval therefor has been obtained, in accordance with the terms and conditions of this Agreement,
for a period requested by XenoPort not to exceed [... * ...] from such termination (for purposes of this Section 16.2, the “Wind-down Period”); provided that XenoPort may terminate the Wind-down Period upon
[... * ...] written notice to Astellas. Notwithstanding any other provision of this Agreement, during the Wind-down Period, Astellas’ and its Subdistributors’ rights with respect to the Compound and the Product in the Affected
Area shall be non-exclusive, and XenoPort shall have the right to engage one or more other distributor(s) and/or sublicensee(s) of the Product in all or part of the Affected Area. Any Products sold or disposed by Astellas in the Affected Area during
the Wind-down Period shall be subject to royalties under Section 7 above. Within [... * ...] of expiration or termination of the Wind-down Period, Astellas shall notify XenoPort of any quantity of the Products remaining in
Astellas’ inventory and Astellas shall transfer all right, title and interest in and to any such quantities of the Products to XenoPort for no consideration. 
 16.2.2 Assignment of MAA and Marketing Approvals. Astellas shall assign or cause to be assigned to XenoPort (or if not so assignable, Astellas shall take all reasonable actions to make available to
XenoPort the benefits of) all regulatory filings and

  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 
registrations (including INDs, MAAs and Marketing Approvals) for the Product in the Affected Area, including any such regulatory filings and registrations made or owned by its Affiliates and/or
Subdistributors. In each case, unless otherwise required by any applicable law or regulation, the foregoing assignment (or availability) shall be made within [... * ...] after termination of the Affected Area. In addition, Astellas
shall promptly provide to XenoPort a copy of all Data, Astellas Know-How and Astellas Manufacturing Know-How pertaining to the Product to the extent not previously provided to XenoPort. 
 16.2.3 Supply. Astellas shall use Diligent Efforts to transition to XenoPort upon XenoPort’s request any arrangements with any
contractor from which Astellas had arranged to obtain a supply of the Compound or Products. In the event that such materials are manufactured by Astellas, then, upon request by XenoPort, Astellas shall continue to provide XenoPort with such
materials [... * ...]; provided that XenoPort shall use commercially reasonable efforts to obtain such alternative source as soon as practicable. In addition, Astellas shall promptly provide to XenoPort a copy of all Data, the Astellas
Know-How and the Astellas Manufacturing Know-How pertaining to the manufacture of the Compound and the Products to the extent not previously provided to XenoPort during the term of this Agreement or pursuant to Section 16.2.2, and XenoPort
shall have the right, subject to Section 10.1, to use (and authorize the use of) and to disclose all such Data, Astellas Know-How and Astellas Manufacturing Know-How pertaining to the manufacture of the Compound and the Products following
termination of this Agreement. 
 16.2.4 Transition. Astellas shall use Diligent Efforts to cooperate with XenoPort
and/or its designee to effect a smooth and orderly transition in the development and sale of the Product in the Affected Area during the Wind-down Period. Without limiting the foregoing, Astellas shall, upon written request from XenoPort, provide
XenoPort copies of customer lists, customer data and other customer information relating to the Product in the Affected Area (except as prevented by the applicable laws and regulations relating to the protection of personal information), which
XenoPort shall have the right to use and disclose for any purpose after termination of this Agreement. In addition, Astellas shall refer all inquiries after the Wind-down Period (or after the termination of this Agreement, in case there is no
Wind-down Period) regarding the Product in the Affected Area to XenoPort or any newly appointed distributors. 
 16.2.5
Return of Materials. Except for any Product in Astellas’ inventory that is transferred to XenoPort as set forth in Section 16.2.1(b), within fifteen (15) days after the end of the Wind-down Period (or after the termination of
this Agreement, in the event there is no Wind-down Period), Astellas shall destroy all tangible items comprising, bearing or containing trademarks, marks, tradenames, patents, copyrights, designs, drawings, formulas or other Data, photographs,
samples, literature, sales and promotional aids (“Product Materials”) and Confidential Information of XenoPort, that is in Astellas’ possession, and provide written certification of such destruction, or prepare such
tangible items of Product Materials and Confidential Information for shipment to XenoPort, as

  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 
XenoPort may direct, at XenoPort’s expense; provided that Astellas may retain copies of Product Materials and Confidential Information relating to countries in the Territory outside the
Affected Area as reasonably necessary for its continued promotion, marketing, sale and distribution of the Product in such countries under this Agreement. Effective upon the end of the Wind-down Period (or upon termination of this Agreement, in the
event there is no Wind-down Period), Astellas shall cease to use all trademarks and trade names of XenoPort in the Affected Area, and all rights granted to Astellas hereunder with respect to the Product in the Affected Area shall terminate.

 16.2.6 Subdistributors. Any contracts with Subdistributors of the Product in the Affected Area engaged by Astellas
other than Astellas’ Affiliates shall, at the request of XenoPort in its discretion, be assigned to XenoPort to the furthest extent possible, provided that such assignment is accepted by the Subdistributor(s) for such Affected Area. In the
event such assignment is not requested by XenoPort or is not accepted by such Subdistributor(s), then the rights of such Subdistributors with respect to the Product in the Affected Area shall terminate upon termination of Astellas’ rights with
respect to such Affected Area. Astellas shall ensure that its Affiliates and such Subdistributors (if not assigned to XenoPort pursuant to this Section 16.2.6) shall transition the Product back to XenoPort in the manner set forth in this
Section 16.2 as if such Affiliate or Subdistributor were named herein. 
 16.3 No Renewal, Extension or Waiver.
Acceptance of any order from, or sale or license of, any Product to Astellas after the effective date of termination of this Agreement shall not be construed as a renewal or extension hereof, or as a waiver of termination of this Agreement.

 16.4 Survival. Upon termination of this Agreement in whole, all rights and obligations of the parties under this
Agreement shall terminate except: (a) Sections [... * ...], and (b) those provisions of this Agreement [... * ...]. For clarity, in the event this Agreement is terminated with respect to one or more countries, but
not the entire Territory, then the Affected Area shall thereafter cease to be within the Territory for all purposes of this Agreement, but Sections [... * ...] shall survive such termination with respect to the Affected Area.

 17. DISPUTE RESOLUTION 
 17.1 Disputes. In the event of any dispute between the Parties arising out of or in connection with this Agreement, either Party may, by written notice to the other, have such dispute referred to
the CEO of XenoPort and the CEO of Astellas for attempted resolution by good faith negotiations within thirty (30) days after such notice is received, and, in such event, each Party shall cause its representative to meet and be available to
attempt to resolve such issue. Notwithstanding the foregoing, neither Party shall be obligated to negotiate for more than thirty (30) days. If the Parties should resolve such dispute or claim, a memorandum setting forth their agreement will be
prepared and signed by both Parties if requested by either Party. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 17.2 Arbitration. Any dispute, controversy or claim with respect to the breach,
interpretation or enforcement of this Agreement, including disputes relating to termination of this Agreement that cannot be resolved pursuant to Section 17.1 (or which this Agreement directs shall be resolved pursuant to this
Section 17.2) shall be settled by binding arbitration in the manner described in this Section 17. The arbitration shall be conducted by the Judicial Arbitration and Mediation Services, Inc. (“JAMS”) under its rules of
arbitration then in effect. Notwithstanding those rules, the following provisions shall apply to the arbitration hereunder: 
 17.2.1 Arbitrators. The arbitration shall be conducted by a single JAMS arbitrator; provided that at the request of either Party, the arbitration shall be conducted by a panel of three (3) arbitrators, with one (1) JAMS
arbitrator chosen by each of Astellas and XenoPort and the third appointed by the other two (2) arbitrators. If the Parties are unable to agree upon a single arbitrator, or the other two arbitrators are unable to agree upon the third arbitrator
in case of a panel of three (3), such single or third arbitrator (as the case may be) shall be appointed in accordance with the rules of JAMS. In any event, the arbitrator or arbitrators selected in accordance with this Section 17.2.1 are
referred to herein as the “Panel” and shall be comprised of arbitrators who are familiar with worldwide research and business development in the pharmaceutical industry, unless otherwise agreed. 
 17.2.2 Proceedings. Except as otherwise provided herein, the Parties and the arbitrators shall use their best efforts to complete
the arbitration within one (1) year after the appointment of the Panel under Section 17.2.1 above, unless a Party can demonstrate to the Panel that the complexity of the issues or other reasons warrant the extension of one or more of the
time tables. In such case, the Panel may extend such time table as reasonably required. The Panel shall, in rendering its decision, apply the substantive law of the State of New York, without regard to its conflicts of laws provisions, except that
the interpretation and enforcement of this Section 17 shall be governed by the U.S. Federal Arbitration Act. The proceeding shall take place in San Francisco, California, United States of America. The arbitral proceedings and all pleadings,
responses and evidence shall be in the English language. If so requested by the arbitrator(s), any evidence originally in a language other than English shall be submitted with an English translation accompanied by an original or true copy thereof.
The decision and/or award rendered by the arbitrator(s) shall be written, final and non-appealable, and judgment on such decision and/or award may be entered in any court of competent jurisdiction. If the Panel determines that it is reasonable to do
so, the fees of the Panel shall be paid by the losing Party, which Party shall be designated by the Panel. Otherwise, the fees of the Panel shall be split equally between the Parties. Each Party shall bear the costs of its own attorneys’ and
experts’ fees; provided that the Panel may in its discretion award the prevailing Party all or part of the costs and expenses incurred by the prevailing Party in connection with the arbitration proceeding. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 17.2.3 Interim Relief. Notwithstanding anything in this Section 17.2 to the
contrary, Astellas and XenoPort shall each have the right to apply to any court of competent jurisdiction for a temporary restraining order, preliminary injunction or other similar interim or conservatory relief, as necessary, pending resolution
under the above described arbitration procedures. Nothing in the preceding sentence shall be interpreted as limiting the powers of the arbitrators with respect to any dispute subject to arbitration under this Agreement. The Panel may award
injunctive relief. 
 18. MISCELLANEOUS 
 18.1 Governing Law, Venue. This Agreement and any dispute arising from the performance or breach hereof shall be governed by, and
construed and enforced in accordance with, the laws of the State of New York, U.S.A., without reference to conflicts of laws principles. The U.N. Convention on the Sale of Goods shall not apply to this Agreement. 
 18.2 Force Majeure. Nonperformance of any Party, except for failure to pay amounts due hereunder, shall be excused to the extent
that performance is prevented by strike, fire, earthquake, flood, acts of terrorism, governmental acts or orders or restrictions, failure of suppliers or any other reason where failure to perform is beyond the reasonable control of the nonperforming
Party (“Force Majeure”). In such event, Astellas or XenoPort, as the case may be, shall promptly notify the other Party of such inability and of the period for which such inability is anticipated to continue. Without limiting the
foregoing, the Party subject to such inability shall use reasonable efforts to minimize the duration of any Force Majeure event. 
 18.3 No Implied Waivers; Rights Cumulative. No failure on the part of XenoPort or Astellas to exercise and no delay in exercising any right under this Agreement, or provided by statute or at law or in equity or otherwise, shall
impair, prejudice or constitute a waiver of any such right, nor shall any partial exercise of any such right preclude any other or further exercise thereof or the exercise of any other right. 
 18.4 Independent Contractors. Nothing contained in this Agreement is intended implicitly, or is to be construed, to constitute
XenoPort or Astellas as partners in the legal sense. No Party hereto shall have any express or implied right or authority to assume or create any obligations on behalf of or in the name of any other Party or to bind any other Party to any
contract, agreement or undertaking with any third party. This Agreement does not create a partnership for United States federal income tax purposes (as defined in Section 761 of the United States Internal Revenue Code), for any state or local
jurisdiction in the United States or in any country other than the United States. Therefore, except for filing regarding withholding tax which, if not filed, shall be imposed upon royalties and milestone payments paid under this Agreement, there is
no requirement to file Form 1065, United States Partnership Return of Income, any similar state or local income tax return or any similar document with tax authorities in any country other than the United States. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 18.5 Notices. All notices, requests and other communications hereunder shall be
in writing and shall be personally delivered or sent by registered or certified airmail, return receipt requested, postage prepaid, in each case to the respective address specified below, or such other address as may be specified in writing to the
other Parties hereto: 
  

			
	Astellas:	  	Astellas Pharma Inc.
		  	3-11, Nihonbashi-Honcho 2-chome
		  	Chuou-ku, Tokyo, 103-8411, Japan
		  	Attn: Vice President, Licensing, Corporate Strategy
		  	Fax: +81-3-5203-7164
		
	With a copy to:	  	Astellas Pharma Inc.
		  	3-11, Nihonbashi-Honcho 2-chome
		  	Chuou-ku, Tokyo, 103-8411, Japan
		  	Attn: Vice President, Legal, Corporate Administration
		  	Fax: +81-3-3244-5811
		
	XenoPort:	  	XenoPort, Inc.
		  	3410 Central Expressway
		  	Santa Clara, California 95051,
		  	United States of America
		  	Attn: CEO
		  	Fax: +1 (408) 616-7211
		
	with a copy to:	  	Wilson Sonsini Goodrich & Rosati
		  	650 Page Mill Road
		  	Palo Alto, California 94304-1050
		  	United States of America
		  	Attn: Kenneth A. Clark, Esq.
		  	Fax: +1 (650) 493-6811

 18.6 Assignment. This Agreement shall not be assignable by either Party
to any Third Party hereto without the written consent of the other Party hereto; except either Party may assign this Agreement without the other Party’s consent to an entity that acquires substantially all of the business or assets of the
assigning Party, whether by merger, acquisition or otherwise, provided that the acquiring Party assumes this Agreement in writing or by operation of law. In addition, either Party shall have the right to assign this Agreement to a Subsidiary upon
written notice to the non-assigning Party; provided that the assigning Party guarantees the performance of this Agreement by such Subsidiary, and further provided that if the non-assigning Party reasonably believes such assignment could result in
material adverse tax consequences to the non-assigning Party, such assignment shall not be made without the non-assigning Party’s consent. Subject to the foregoing, this Agreement shall inure to the benefit of each Party, its successors and
permitted assigns. Any assignment of this Agreement in contravention of this Section 18.6 shall be null and void. 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 18.7 Modification. No amendment or modification of any provision of this
Agreement shall be effective unless in writing signed by all Parties hereto. No provision of this Agreement shall be varied, contradicted or explained by any oral agreement, course of dealing or performance or any other matter not set forth in an
agreement in writing and signed by all Parties. 
 18.8 Severability. If any provision hereof should be held
invalid, illegal or unenforceable in any jurisdiction, the Parties shall negotiate in good faith a valid, legal and enforceable substitute provision that most nearly reflects the original intent of the Parties and all other provisions hereof shall
remain in full force and effect in such jurisdiction and shall be liberally construed in order to carry out the intentions of the Parties hereto as nearly as may be possible. Such invalidity, illegality or unenforceability shall not affect the
validity, legality or enforceability of such provision in any other jurisdiction. In the event a Party seeks to avoid a provision of this Agreement by asserting that such provision is invalid, illegal or otherwise unenforceable, the other Party
shall have the right to terminate this Agreement upon sixty (60) days’ prior written notice to the asserting Party, unless such assertion is eliminated and the effect of such assertion is cured within such sixty (60) day period.
Any termination in accordance with the foregoing sentence shall be deemed an election by Astellas to terminate pursuant to Section 15.2 if XenoPort exercises its right to terminate under this Section 18.8, and a termination for the
breach of XenoPort pursuant to Section 15.3 if Astellas exercises its right to terminate under this Section 18.8. 
 18.9 Counterparts. This Agreement may be executed in two counterparts, each of which shall be deemed an original, and all of which, together, shall constitute one and the same instrument. 
 18.10 Headings. Headings used herein are for convenience only and shall not in any way affect the construction of, or be taken
into consideration in interpreting, this Agreement. 
 18.11 Export Laws. Notwithstanding anything to the contrary
contained herein, all obligations of XenoPort and Astellas are subject to prior compliance with United States and foreign export regulations and such other United States and foreign laws and regulations as may be applicable, and to obtaining all
necessary approvals required by the applicable agencies of the governments of the United States and foreign jurisdictions. XenoPort and Astellas shall cooperate with each other and shall provide assistance to the other as reasonably necessary to
obtain any required approvals. 
 [continued on next page] 
  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 18.12 Entire Agreement. This Restated License Agreement, together with
all the Exhibits thereto, constitute the entire agreement, both written or oral, with respect to the subject matter hereof, and supersede all prior or contemporaneous understandings or agreements, whether written or oral, between XenoPort and
Astellas with respect to such subject matter on and after the Restatement Effective Date. The Original Agreement shall govern the rights and obligations between the Parties prior to the Restatement Effective Date, and this Restated License Agreement
shall govern the rights and obligations between the Parties on and after the Restatement Effective Date. 
 IN WITNESS WHEREOF,
the Parties hereto have caused this Restated License Agreement to be duly executed and delivered in duplicate originals as of the Restatement Effective Date. 
  

									
	XENOPORT, INC.	 		 	ASTELLAS PHARMA, INC.
					
	By:	  	 /s/ Ronald W. Barrett
	 		 	By:	 	 /s/ Chihiro Yokota

	Name:	  	 Ronald W. Barrett
	 		 	 Name:
	 	 Chihiro Yokota

	Title:	  	 Chief Executive Officer
	 		 	Title:	 	 Vice President, Licensing and Alliances


  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 EXHIBIT A 
 COMPOUND 
 [... * ...] 

 

  
 * CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS,
IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 








 EXHIBIT B 
 XENOPORT PATENT RIGHTS 
 [... * ...]

  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 









 EXHIBIT C 
 INITIAL DEVELOPMENT PLAN 
 [... * ...]

  

  

	*	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT,
MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED.