ex4_84.htm


    Exhibit
4.84

     

    AMR101:  14
Day Dose Range Finding Toxicity Study in Dogs by Oral Gavage Administration
515147

     

    “Companies”

     

    APPENDIX
1


     

    WORK
ORDER

     

    This
WORK ORDER dated as of
the date of last signature below

     

    BETWEEN

     

    
      	
              (1)

            	
              AMARIN NEUROSCIENCE LTD
      of 1st Floor, Magdalen Centre North, The Oxford Science Park Oxford,
      OX44GA(“Amarin”)

            


    

     

    
      	
              (2)

            	
              AMARIN PHARMACEUTICALS IRELAND
      LIMITED having its principal place of business at First Floor,
      Block 3, The Oval, Shelbourne Road, Ballsbridge, Dublin 4, Ireland (“APIL”)

            


    

     

    
      	
              (3)

            	
              CHARLES RIVER LABORATORIES
      PRECLINICAL SERVICES EDINBURGH LIMITED having its principal place
      of business at Elphinstone Research Centre, Tranent, Edinburgh, EH33 2NE,
      UK (“Charles
      River”)

            


    

     

    WHEREAS

     

    
      	
              A

            	
              Amarin,
      APIL and Charles River are bound by the terms of the Master Services
      Agreement dated 25 August 2008 between Amarin and Charles River (the
      “Master Services
      Agreement”)

            


    

     

    
      	
              B

            	
              The
      terms and conditions of the Master Services Agreement govern this Project Work
      Order in respect to the following project:  [AMR101:  14 Day Dose
      Range Finding Toxicity Study in Dogs by Oral Gavage Administration]
      (the “Project”),
      with the following additional provisions
  applying:

            


    

    
 

    
      
        	
                Schedule
      1

              	
                Project
      Protocol

              
	
                Schedule
      2

              	
                Timelines

              
	
                Schedule
      3

              	
                Budget
      and Payment Schedule

              
	
                Schedule
      4

              	
                Budget
      Breakdown

              


      

This Work
Order has an Effective Date as of the last date of signature and will remain
valid until completion of Services described herein and when Amarin has paid the
final invoice in accordance with the terms of the Master Services
Agreement.


    
      
         


      

      
         


        
          

        

      

      
         


      

    


    AGREED AND ACCEPTED by the
parties

     

    

      For and
on behalf of Amarin
Neuroscience Ltd

       

      
        	
                Signed
      ________________________________

              	
                Date
      ___________________________

              
	 
      	 
      
	
                Name   ________________________________

              	
                Position 
      ________________________

              


      

      


      For and
on behalf of Amarin
Pharmaceuticals Ireland Limited

      
         

        
          	
                  Signed
      ________________________________

                	
                  Date
      ___________________________

                
	 
      	 
      
	
                  Name   ________________________________

                	
                  Position 
      ________________________

                


        

        
For and
on behalf of Charles River
Laboratories Preclinical Services Edinburgh Limited

      

      
         

        
          	
                  Signed
      ________________________________

                	
                  Date
      ___________________________

                
	 
      	 
      
	
                  Name   ________________________________

                	
                  Position 
      ________________________

                


        

        


      

       




    
      
         


      

      
        -2-

        
          

        

      

      
         


      

    


    SCHEDULE
1:  PROJECT PROTOCOL

     

    AMR101:  14
Day Dose Range Finding

    Toxicity
Study In Dogs by Oral Gavage Administration

    Charles
River Study Number 515147


    
      
         


      

      
        -3-

        
          

        

      

      
         


      

    


    SCHEDULE
2.:  TIMELINES

     

    
      	
              Animal
      Arrival (Stock):

            	
              10
      April 2008

            
	 	 
	
              First
      day of dosing (Day 1):

            	
              16
      September 2008

            
	 	 
	
              Last
      day of dosing (Day 14):

            	
              29
      September 2008

            
	 	 
	
              Terminal
      necropsies (Day 15):

            	
              30
      September 2008

            
	 	 
	
              Completion
      of Experimental Work:

            	
              30
      September 2008

            
	 	 
	
              Non-QA
      Draft Report:

            	
              21
      November

            


    

    



    
      
         


      

      
        -4-

        
          

        

      

      
         


      

    


    SCHEDULE
3:  BUDGET AND PAYMENT SCHEDULE

     

    
      	
              ·  

            	
              All
      invoices will be issued in Pound Sterling and are to be paid in Pound
      Sterling.

            


    

     

    
      	
              ·  

            	
              The
      total cost far the Services detailed In this Work Order is £26,000 and the
      total estimated related expanses have been detailed in Schedule
      4.

            


    

     

    
      	
              ·  

            	
              The
      authorised Amarin contact shall be Trevor
Wyeth.

            


    

     

    
      	
              ·  

            	
              The
      authorised Charles River contact for this work shall be Catherine
      Nichols.

            


    

     

    
      	
              ·  

            	
              All
      invoices will state the Amarin protocol number, activity performed,
      purchase order number (if available), contact name and will be submitted
      to the following address:

            


    

     

    

      
        	
                Amarin
      Neurosciences Ltd

                 

                1st
      Floor

                Magdalen
      Centre North

                The
      Oxford Science Park

                Oxford

                OX4
      4GA

                 

                With
      a copy sent to:

                 

                Amarain
      Pharmaceuticals Ireland Limited

                1st
      Floor, Block 3

                The
      Oval

                Shelbourne
      Road

                Ballsbridge

                Dublin
      4

                Ireland

              


      



    Payment
Schedule

     

    
      	
              Signature
      of Contract:

            	
              30%
      of Budget - £7,800

            
	
              Start
      of Experimental Work:

            	
              40%
      of Budget - £10,400

            
	
              Completion
      of Experimental Work:

            	
              20%
      of Budget - £5,200

            
	
              Unaudited
      Drafted Report:

            	
              10%
      of Budget - £2,600

            


    

    



    
      
         


      

      
        -5-

        
          

        

      

      
         


      

    


    SCHEDULE
4:  BUDGET BREAKDOWN

     

    The
budget breakdown is detailed below:

     

    
      	
              Purchase
      and Pretrial housing of Animals

            	
              3,000

            
	 	 
	
              Study
      Management & Reporting

            	
              12,300

            
	 	 
	
              Formulation,
      including test item receipt

            	
              1,000

            
	 	 
	
              Housing,
      Dosing and animal room data collection

            	
              4,000

            
	 	 
	
              Necropsy

            	
              1,700

            
	 	 
	
              Clinical
      Pathology

            	
              4,000

            
	 	 
	
              Grand
      Total

            	
              26,000

            


    

    


     

    Expenses –
Estimates

     

    (to
be inserted)

    


     

     

     

    -6-