|SECURITIES AND EXCHANGE COMMISSIONWASHINGTON, D.C. 20549FORM 10-K                  
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|Annual Report Pursuant to Section 13 or 15(d) ofthe Securities Exchange Act of 1934

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|For the Fiscal Year Ended | Commission File No. 0-11550
|December 31, 2004         |                            

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|Pharmos Corporation(Exact name of registrant as specified in its charter)
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|Nevada                          |  | 36-3207413            
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|(State or other jurisdiction of |  | (IRS Employer Id. No.)
|incorporation or organization)  |  |                       

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|99 Wood Avenue South, Suite 311Iselin, NJ 08830(Address of principal executive offices) (zip code)
  Registrants telephone number, including area code: (732) 452-9556
Securities registered pursuant to Section 12(b) of the Act:
None (Title of Class)
Securities registered pursuant to Section 12(g) of the Act:
Common Stock, $.03 par value (Title of Class)
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section
13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter
period that the registrant was required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes  No .
Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is
not contained herein, and will not be contained, to the best of registrants knowledge, in definitive
proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment
to this Form 10-K.
Indicate by check mark whether the registrant is an accelerated filer (as defined in Rule 12b-2 of
the Act). Yes  No .
The aggregate market value of the registrants Common Stock at June 30, 2004 held by those persons
deemed to be non-affiliates was approximately $383,861,949.
As of March 8, 2005, the Registrant had outstanding  95,137,076 shares of its $.03 par value  Common
Stock.

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|PART I
This Form 10-K contains forward-looking statements, as defined in the Private Securities
Litigation Reform Act of 1995 that are based on current expectations, estimates and projections.
Statements that are not historical facts, including statements about our beliefs and expectations,
are forward-looking statements. These statements involve potential risks and uncertainties; therefore,
actual results may differ materially. You are cautioned not to place undue reliance on these forward-looking
statements, which speak only as of the date on which they were made. We do not undertake any obligation
to update any forward-looking statements, whether as a result of new information, future events or
otherwise.
Important factors that may affect these expectations include, but are not limited to: the risks and
uncertainties associated with completing pre-clinical and clinical trials of our compounds that demonstrate
such compounds safety and effectiveness; manufacturing losses and risks associated therewith;
obtaining additional financing to support our operations; obtaining and maintaining regulatory approval
for such compounds and complying with other governmental regulations applicable to our business;
obtaining the raw materials necessary in the development of such compounds; consummating and maintaining
collaborative arrangements with corporate partners for product development; achieving milestones
under collaborative arrangements with corporate partners; developing the capacity to manufacture,
market and sell our products, either directly or with collaborative partners; developing market demand
for and acceptance of such products; competing effectively with other pharmaceutical and biotechnological
products; obtaining adequate reimbursement from third party payers; attracting and retaining key
personnel; obtaining patent protection for discoveries and risks associated with commercial limitations
imposed by patents owned or controlled by third parties; and those other factors set forth in Risk
Factors in the Companys most recent Registration Statement.
We do not undertake to discuss matters relating to our ongoing clinical trials or our regulatory strategies
beyond those which have already been made public or discussed herein.
Item 1. Business
Introduction
Pharmos Corporation (the Company or Pharmos) is a bio-pharmaceutical company that discovers and develops
new drugs to treat a range of neuro-inflammatory disorders. We have a portfolio of drug candidates
and compounds in various development stages, including clinical, preclinical and discovery. Our proprietary
technology platform includes several families of synthetic non-psychotropic cannabinoid compounds.
The two families most advanced in development are the tricyclic dextrocannabinoids, which do not
bind appreciably to cannabinoid receptors, and the bicyclic CB2-selective compounds, which are cannabinoid
receptor agonists that bind preferentially to CB2 receptors found primarily in peripheral immune
cells. To date, our principal sources of cash have been public and private financings, the sale of
our ophthalmic business, revenues from our ophthalmic product line prior to the sale, research grants
and the sale of a portion of our New Jersey net operating loss carryforwards.
Our most advanced product candidate is dexanabinol, a synthetic, non-psychotropic dextrocannabinoid
currently in Phase II clinical development as a preventive agent against cognitive impairment following
cardiac surgery. An exploratory Phase IIa trial was completed in November 2004 where a statistically
significant difference between drug and placebo-treated groups was observed in the Stroop test, a
measure of high-level integrative function in the brain. In this exploratory study, significant differences
between drug and placebo were not seen in several measures of individual cognitive domains.
In a separate Phase III clinical trial, where dexanabinol was tested as an agent to treat severe traumatic
brain injury (TBI), no significant differences between drug and placebo groups were seen. While efficacy
was not observed, the trial demonstrated an excellent safety profile with no evidence of excess side
effects in the dexanabinol-treated patients. This trial was completed and the results announced in
December 2004. The
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|TBI program has been discontinued, and detailed results will be reported to the FDA and published in
the scientific literature.
From the CB2-selective family of compounds, cannabinor (formerly known as PRS-211,375) is the most
advanced and is scheduled to begin clinical development during 2005 for pain indications. Cannabinor
and other CB2-selective compounds preferentially activate the CB2 cannabinoid receptor. Preclinical
investigations of these compounds have demonstrated pharmacological activity as analgesic, anti-inflammatory,
and immunomodulatory agents that may effectively treat multiple neuro-inflammatory and autoimmune
disorders, such as various types of pain, multiple sclerosis, rheumatoid arthritis, etc. In preparation
for clinical testing, cannabinor is in advanced preclinical testing for toxicology and absorption,
distribution, metabolism, excretion (ADME). Pending successful completion of preclinical
studies, the Company plans to initiate human testing of cannabinor during the second half of 2005.
For both the tricyclic dextrocannabinoid and the bicyclic CB2-selective cannabinoid families, unwanted
psychotropic side effects that are generally associated with naturally occurring cannabinoids
are reduced or absent. Psychotropic side effects induced by other cannabinoids result from their
binding to the CB1 cannabinoid receptor in the brain. CB1 activity is either absent or very low in
compounds selected by the Company for drug development.
In December 2004, the Companys former marketing partner, Bausch & Lomb Incorporated (Bausch
& Lomb), received approval from the FDA of its New Drug Application (NDA) for
Zylet as an ophthalmic anti-inflammatory antibiotic combination drug which the Company sold
its rights subject to certain payment milestones. The Company received net proceeds of approximately
$9.1 million from Bausch & Lomb during the first quarter of 2005.
Strategy
Pharmos business is the discovery and development of new drugs to treat a range of neurological
and inflammatory disorders. We seek to enter into collaborative relationships with established pharmaceutical
companies to complete development and commercialization of our products.
Pharmos applies its experience in rational drug design, novel drug delivery technology and drug development
to develop neuro-protective and anti-inflammatory products directed at several therapeutic indications,
including cognitive impairment following cardiac surgery, various types of pain, including neuropathic,
cancer and post-surgical pain, multiple sclerosis, rheumatoid arthritis, and others.
Products
Platform Technologies
Pharmos is developing families of compounds based on its scientific knowledge of the medicinal activities
of cannabinoids, compounds with chemical structures or receptor-binding properties related to the
main active component of cannabis. The company utilizes state-of-the-art technologies to synthesize,
evaluate and develop new cannabinoid molecules that appear to exhibit enhanced therapeutic benefit.
According to Pharmos research, dexanabinol and cannabinor have been shown to possess minimal
psychotropic properties. As part of the filing requirements with FDA, Pharmos will study the addiction
potential of dexanabinol and cannabinor. If the potential of addiction is found in animal tests,
then additional regulatory requirements may be imposed by the FDA and Drug Enforcement Agency (DEA).
Pharmos continues to expand its library of compounds through a hybrid methodology combining the rational
design of compounds based on knowledge of detailed molecular requirements for drug activity with
combinatorial chemistry, a technique that utilizes randomized chemical reactions to synthesize large
numbers of different molecules. In contrast to the conventional random methods of combinatorial chemistry,
this hybrid approach leads to a larger percentage of synthesized compounds that demonstrate activity
in screening assays and increases the potential of developing potent and selective drug candidates.
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|Pharmos chemical library consists of several chemically distinct classes of cannabinoid compounds.
The two most advanced classes are the tricyclic dextrocannabinoids and bicyclic CB2-selective cannabinoids.
While the different classes of synthetic cannabinoids vary in their mechanisms of action, there is
considerable overlap in their therapeutic potential for treating neurological, cardiovascular, autoimmune
and inflammatory disorders.
Tricyclic dextrocannabinoids
The tricyclic dextrocannabinoids, for which dexanabinol is the prototype, do not bind appreciably to
either of the two known classes of cannabinoid receptors. Therefore, the tricyclic dextrocanabinoids
demonstrate minimal psychotropic and other negative side effects that are associated with naturally
occurring cannabinoids. The biological activity of drug candidates in this family derives from their
ability to block the activation of specific NMDA mediated channels in nerve cells and/or attenuating
several major inflammatory mechanisms by modulating the synthesis of pro-inflammatory factors. Both
activities may reduce the amount of sudden and programmed cell death caused by certain disorders.
As discussed below, dexanabinol has undergone one exploratory Phase IIa trial for use as a preventive
agent against cognitive impairment (CI) that can follow coronary artery bypass graft (CABG) surgery,
the results of which were announced in November 2004, and a Phase III trial for the treatments of
severe TBI, the results of which were announced in December 2004. The TBI program has been discontinued,
and detailed results will be reported to the FDA and published in the scientific literature. Other
tricyclic dextrocannabinoids are under evaluation in preclinical models for neuropathic pain, which
results from nerve damage or dysfunction; nociceptive pain, which is caused by activation of nerve
sensors as a result of acute tissue damage; and autoimmune disorders such as multiple sclerosis.
Dexanabinol
Phase IIa Trial of Dexanabinol to Prevent Cognitive Impairment in Following Coronary Artery Bypass
Graft Surgery
In November 2004, the Company announced the results of the double-blind, placebo controlled Phase IIa
trial of dexanabinol as a preventive agent against cognitive impairment (CI) following coronary artery
bypass graft (CABG) surgery. In this study, 202 patients aged 60 years or older with no clinical
evidence of neurological or psychiatric symptoms and with no evidence of existing dementia undergoing
elective CABG surgery were enrolled at six medical centers in Israel. Patients were given a single
dose of either 150 mg dexanabinol or placebo just before surgery. Primary and secondary efficacy
parameters were assessed for each patient at six weeks and three months post-surgery and compared
to baseline pre-surgery scores. The primary endpoint was the effect of dexanabinol compared to placebo
on reduction of post-CABG cognitive impairment as measured by five computerized tests plus the Stroop
test and analyzed by multiple analysis of variance (MANOVA).
The trial did not achieve its primary statistical endpoint of detecting a statistical difference in
the five composite cognitive test domains plus the Stroop test analyzed simultaneously by MANOVA
(p=0.37). The power of the MANOVA, however, was substantially reduced by incomplete test data for
39 patients at three months. In a univariate output of the primary analysis, a trend toward significance
was found in the Stroop test results. Further analysis using all available data revealed a trend
toward significance at six weeks and at three months, the Stroop test achieved a statistically and
clinically relevant difference when compared to placebo (p=0.01). This test showed that dexanabinol
preserved higher integrative decision -making function when compared to placebo at three months post-surgery.
The Stroop test is a test of selective attention and interference susceptibility. These skills have
implications for the performance of everyday tasks that involve focused attention, cognitive impulse
control, and decision-making. Improvements in the Stroop test by the dexanabinol-treated patients
over the placebo-treated patients may reflect a preservation of the brains higher cognitive
functions and learning mechanisms that can be vulnerable to effects from surgery. The data showed
dexanabinol was safe and well tolerated in this study.
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|Phase III Trial of Dexanabinol for the Treatment of Severe TBI
In December 2004, the Company announced the results of the double-blinded, placebo controlled Phase
III trial of dexanabinol for the treatment of severe TBI. Despite the high quality data generated
by the investigative sites and a rigorous statistical methodology, no difference between dexanabinol
and placebo could be detected. The study population was well matched and all other TBI treatment
was standardized and monitored by an independent medical reviewer during the course of the trial.
The TBI program has been discontinued, and detailed results will be reported to the FDA and published
in the scientific literature.
The pivotal Phase III clinical trial of dexanabinol for TBI was a double-blinded, randomized, placebo-controlled
trial conducted in European, Israeli, Australian and U.S. trauma centers. To maximize the probability
of detecting a clinical benefit to severe TBI patients and to ensure a common protocol for the multinational
trial, the Clinical Plan was carefully designed in collaboration with a panel of worldwide TBI experts
who were chairman and members of the European Brain Injury Consortium (EBIC) and the
American Brain Injury Consortium (ABIC). Among the several inclusion criteria that had
to be satisfied, a patient must have sustained a severe brain injury as judged by both a Glasgow
Coma Score (GCS) between 4 and 8 and by a CT scan showing brain parenchymal damage. In
addition, a patient must have been administered the single dose of placebo or 150 mg of the drug
within 6 hours of injury.
Patients were evaluated at 3 and 6 months according to the Glasgow Outcome Scale Extended (GOSE).
Results of the trial were analyzed by grouping patients into three outcome bands according to their
baseline prognostic risk factors which were based on seven independent prognostic indicators. For
each prognostic band, the GOSE scores were dichotomized to differentiate favorable and
unfavorable outcome. The goal of the study was to observe at six months a statistically
significant increase in the number of dexanabinol-treated patients achieving a favorable outcome
when compared to the placebo group. The six-month outcome demonstrated an odds ratio of l.04 in favor
of dexanabinol with a 95% confidence interval of 0.79 to 1.36 (p=0.78).
Bicyclic CB2-selective cannabinoids
Bicyclic CB2-selective cannabinoids are synthetic compounds which as opposed to the tricyclic dextrocannabinoids
belong to the class of nonclassical cannabinoids. Though the two classes are structurally distinct,
they share some similar activities. The bicyclic cannabinoids possess some additional properties
such as improved immunomodulatory and analgesic activities.
As with the tricyclic dextrocannabinoids, the bicyclic cannabinoids may display less of the undesired
psychotropic side-effects seen with some natural cannabinoids. However, the molecular activity of
the bicyclics is different from the tricyclics in that the bicyclic cannabinoids bind with high affinity
to the cannabinoid type two (CB2) receptor which is located primarily on immune and inflammatory
cells and with lower affinity to the cannabinoid type one (CB1) receptor, located in the central
nervous system. In contrast to CB1 receptors, CB2 receptors are expressed mainly in the periphery,
on immune and inflammatory cells, including mast cells that are thought to play a role in triggering pain.
Our bicyclic cannabinoid library has been generated with the aid of combinatorial and computational
chemistry that incorporates rational design based on structure activity relationships (SAR). Many
of these inherently lipophilic compounds have been modified to make them water-soluble. Pharmos has
developed a robotically-assisted high throughput screening (HTS) process to test compounds for different
sets of properties, including (i) binding to the CB1, CB2 and NMDA receptors, (ii) inhibition of
LPS-induced release from macrophages of prostaglandin E2 (reflecting inhibition of COX-2), iNOS and
TNF-alpha, (iii) inhibition of PMA/calcium ionophore-induced release of cytokines from Jurkat cells
(a human T-cell line), and (iv) activation of several transcription factors in Jurkat cells. Additional
anti-inflammatory potential is assessed by screening compounds for their ability to affect the expression
of genes involved in inflammation as measured with a panel of stably transfected cell lines generated
at Pharmos. Compounds that show potent
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|activity in one or more of the screening assays are tested in secondary screens. The most important
secondary screens are inhibition of forskolin-induced adenylyl cyclase in stable CB2-transfected
cell lines, and inhibition of inflammation as measured by paw edema. The most promising compounds
are then tested in validated animal models of human pain, including tail flick for noxious pain,
carrageenan-induced paw edema for inflammatory pain, and the chronic sciatic nerve ligation (Bennett & Xie) model for neuropathic pain. Employing this strategy has led generated a number of compounds
for intensive investigation, leading to cannabinor as a lead drug candidate that is planned to enter
the clinical stage of development in 2005. Pharmaceuticals that preferentially activate the CB2 receptors
may be important in treating various pain syndromes as well as autoimmune, inflammatory and neuro-degenerative
disorders. Several candidates from Pharmos bicyclic cannabinoid library have demonstrated promise
in animal models for autoimmune inflammatory disorders such as multiple sclerosis and rheumatoid
arthritis. These compounds have also demonstrated efficacy in animal models of neuropathic and nociceptive
pain. In preclinical models these compounds have demonstrated analgesic activity equivalent to morphine
but without the unwanted opioid side effects such as sedation and repiratory depression. The anti-inflammatory
activity of these compounds is equivalent or superior to non-steroidal anti-inflammatory drugs (NSAIDS).
Cannabinor, the lead compound from this library, demonstrates an optimal combination of CB2 specificity
and analgesic and anti-inflammatory potency. Additionally, cannabinor is water soluble, making
it suitable for both parenteral and oral administration. After testing cannabinor in preclinical
experiments on a variety of animal models to assess its analgesic and other therapeutic potentials,
it was selected as the lead compound of the CB2 library and, as of the end of 2004, is in late-stage
preclinical development with clinical development for pain indications planned to begin in 2005.
Potential pharmaceutical markets for Pharmos bicyclic CB2-selective cannabinoids
The development of novel CB2-selective diseasemodifying agents (DMA) that combine anti-inflammatory,
immunomodulatory and analgesics properties for the treatment of inflammatory/autoimmune diseases
is a major goal of Pharmos research and discovery activity. Inflammation and immunodysregulation
plays a pivotal role in a majority of chronic and debilitating autoimmune diseases such as rheumatoid
arthritis (RA), inflammatory bowel disease (IBD) and multiple sclerosis (MS). Treatment and healthcare
costs associated with these diseases have been estimated to exceed $500 billion annually. Recent
products introduced in this market have been limited due to lack of efficacy and/or severe side effect
profile. Pharmos novel CB2-selective bicyclic cannabinoids may be powerful anti-inflammatory,
immunomodulator and analgesics for the treatment of cancer and neuropathic pain as well as pain derived
from inflammatory autoimmune diseases such as MS, RA and IBD.
The analgesic market where unmet medical needs remain can be categorized into five major syndromes;
cancer pain, back pain, HIV pain, neuropathies, and arthritic/osteoarthitic pain. The incidence and
prevalence of the major pain syndromes continues to increase with an estimated patient potential
in 2009 of over 368 million. In 2000 the global market for analgesics was about $16 billion. Global
analgesic sales increased to more than $22 billion for 2002 and are predicted to increase to $30
billion by 2009. In the US, spending for drugs to treat neuropathic pain is anticipated to exceed
$1 billion by 2009. At present, there is no specific or satisfactory analgesic for neuropathic pain.
Opioids and NSAIDs are ineffective. Pfizers gabapentin, a GABA analog whose main indication
is epilepsy, remains the most frequently used drug for neuropathic pain, with tricyclic antidepressants,
including amitriptylline, coming second. Neuropathic pain occurs most commonly in diabetes, cancer,
multiple sclerosis, stroke, amyotrophic lateral sclerosis, HIV, trigeminal and post-herpetic neuralgia,
and after trauma (traumatic neuralgia, phantom limb surgery). The main symptoms are spontaneous (i.e.
not triggered by noxious stimuli), severe shooting pains, hyperalgesia and allodynia (painful sensations
evoked by light touch or small changes in temperature that do not normally elicit pain).
These potential markets are extremely attractive for analgesics that can effectively manage pain experienced
by patients suffering from any of these syndromes. The properties of our CB2-selective cannabinioids
place them in a good position for potential deployment in several of these major pain syndromes.
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|Cannabinor
Cannabinor has been found to be pharmacologically active in nociceptive, inflammatory, visceral and
neuropathic pain models in rodents. In animal model experiments, the drug candidate was as potent
as morphine in blocking noxious pain in the tail flick test, inflammatory pain in the carrageenan-induced
paw edema model, and neuropathic pain in the Bennet & Xie model. In the tail flick test, cannabinor
was longer-acting than morphine. When administered chronically, cannabinor did not elicit tolerance
in the tail flick test, unlike the tolerance that develops during chronic morphine administration.
Cannabinor also was effective in blocking acetic-acid induced visceral pain. The analgesic efficacy
of cannabinor was also demonstrated in large animals by a pain model in pigs. The analgesic action
of cannabinor in inflammatory and visceral pain models was shown to be mediated by the non-psychoactive
CB2 receptor by incorporating selective cannabinoid receptor antagonists in the experimental design.
Importantly, cannabinor was effective in blocking inflammatory pain when administered orally.
Additionally, cannabinor was pharmacologically active when administered orally in the experimental
autoimmune encephalomyelitis (EAE) model for MS. The drug candidate may carry the dual advantage
of reducing the neurological deficits as well as inhibiting the neuropathic pain and muscle spasticity
that occur in multiple sclerosis. Additional data suggest that cannabinor may suppress the autoimmune
inflammation associated with rheumatoid arthritis.
Cannabinors safety is under evaluation in rats and monkeys in a battery of GLP toxicology studies
including genotoxicity, safety pharmacology, acute and repeat-dose toxicity and pharmacokinetic/ADME
studies. Scale-up and GMP manufacturing of cannabinor as the active pharmaceutical ingredient (API)
for the production of clinical trial material (CTM) is ongoing. Subject to successful completion
of safety/toxicology studies and acceptance of appropriate submission by regulatory agencies, the
Company plans to initiate Phase I human testing of cannabinor for safety and tolerability during
the second half of 2005 followed by Phase II studies in acute and chronic pain indications.
In parallel to the pharmaceutical development of cannabinor, Pharmos is expanding its combinatorial
chemical library with additional synthetic compounds that are being screened for pharmacological
activity and new therapeutic applications using in vitro and in vivo techniques. The chemical synthesis
of new compounds is based on novel chemical modifications for improving selectivity, solubility and
simplicity of synthetic process.
Other compounds
In addition to the above mentioned cyclic cannabinoids, new platforms of synthetic cannabinoid-related
compounds are being developed. The new compounds possess advantages such as a simpler synthesis and
improved water solubility. Members of the new families have improved physicochemical properties are
being tested in vitro and in vivo for potential efficacy.
Loteprednol Etabonate
Loteprednol etabonate is a unique steroid that is designed to act in the eye and alleviate inflammatory
and allergic conditions and that is quickly and predictably reduced into inactive particles before
it reaches the inner eye or systemic circulation. This action results in improved safety by avoiding
the side effects related to exposure to most ocular steroids. In the eye, the most unwanted side
effect of steroids is the elevation of intra-ocular pressure, which can be sight threatening. While
steroids, for lack of an alternative, are regularly used for severe inflammatory conditions of the
eye, milder conditions such as allergies are preferentially treated with less effective non-steroidal
agents.
Pharmos sold all of its rights to its ophthalmic product line to Bausch & Lomb for cash and assumption
of certain ongoing obligations. Please refer to the description of the transaction under the heading,
Bausch & Lomb, below.
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|Competition
The pharmaceutical industry is highly competitive. Pharmos competes with a number of pharmaceutical
companies that have financial, technical and marketing resources that are significantly greater than
those of Pharmos. Some companies with established positions in the pharmaceutical industry may be
better equipped than Pharmos to develop, market and distribute products in the markets Pharmos is
seeking to enter. A significant amount of pharmaceutical research is also being carried out at universities
and other not-for-profit research organizations. These institutions are becoming increasingly aware
of the commercial value of their findings and are becoming more active in seeking patent protection
and licensing arrangements to collect royalties for the use of technology they have developed. They
may also market competitive commercial products on their own or through joint ventures and will compete
with Pharmos in recruiting highly qualified scientific personnel. Further, these institutions will
compete with Pharmos in recruiting qualified patients for enrollment in their trials.
Pharmos is pursuing areas of product development in which there is a potential for extensive technological
innovation. Pharmos competitors may succeed in developing products that are more effective
than those of Pharmos. Rapid technological change or developments by others may result in Pharmos
potential products becoming obsolete or non-competitive.
We know of no products on the market or in late stage trials which would be competitive with dexanabinol.
For Bausch & Lombs ophthalmic product, Zylet, in which we have a financial interest there
are competing products currently on the market including Tobradex® from Alcon, which is the
largest selling product in its category, as well as Vexol® from Alcon and Pred Forte® from
Allergan.
Dr Alexandros Makriyannis from the University of Connecticut has filed several patents relating to
CB2 cannabinoid ligands and mimetics. MakScientific, a company founded by Dr. Makriyannis in 2003,
is developing technologies originating from AlexiPharma and the University of Connecticut. In 2004,
MakScientific has licensed its existing and future preclinical library of compounds with selective
CB2 agonist activity to Endo Pharmaceuticals, for use in the fields of pain and selected CNS disorders.
Other University labs are carrying out academic research on CB2 agonists. According to recent reports
presented at scientific meetings, there are other companies pursuing the development of synthetic
cannabinoid derivatives with low psychotropic side effects for the treatment of severe and chronic
pain conditions. Indevus is developing IP 751, an anti-inflammatory and analgesic compound, as a
potential treatment for both acute and chronic pain. A Phase II trial with IP 751, conducted by researchers
in Germany and published in the Journal of the American Medical Association (JAMA 2003; 290(13):
1757-1762), showed that patients treated with this compound experienced a significant reduction in
neuropathic pain. In addition, the drug was well tolerated, with no major adverse psychological or
physical effects observed. An IND has been filed with the FDA, and an initial Phase I clinical trial
designed to assess the safety of IP 751 demonstrated that it was well tolerated and showed no evidence
of psychotropic activity. Indevus is completing the scale-up and manufacturing of IP 751 in anticipation
of beginning additional Phase I trials starting in early 2005. Indevus licensed exclusive worldwide
rights to IP 751 from Manhattan Pharmaceuticals, Inc.
Collaborative Relationships
Pharmos commercial strategy is to develop products independently and, where appropriate, in collaboration
with established pharmaceutical companies and institutions. Collaborative partners may provide financial
resources, research and manufacturing capabilities and marketing infrastructure to aid in the commercialization
of Pharmos products in development as well as potential future products. Depending on the availability
of financial, marketing and scientific resources, among other factors, Pharmos may license its technology
or products to others and retain profit sharing, royalty, manufacturing, co-marketing, co-promotion
or similar rights. Any such arrangements could limit Pharmos flexibility in pursuing alternatives
for the commercialization of its products. Due to the often unpredictable nature of the collaborative
process, Pharmos cannot be certain that it will be able to establish any additional collaborative
arrangements or that, if established, any of these relationships will be successful.
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|Bausch & Lomb
In 2001, Pharmos sold to Bausch & Lomb all of its rights in the U.S. and Europe to manufacture
and market Lotemax® and Alrex® and Zylet, the third loteprednol etabonate-based product,
which was submitted to the FDA for marketing approval in September 2003. In December 2004, Bausch
& Lomb received approval from the FDA of its NDA for Zylet as an ophthalmic anti-inflammatory/antibiotic
combination product.
At the time of the sale, Pharmos received gross proceeds of approximately $25 million in cash in 2001.
During January 2005, an amended agreement was signed in regard to Zylet and Pharmos received additional
gross proceeds of approximately $12.2 million from Bausch & Lomb. Additionally, the Company may
receive a milestone payment of up to $10 million if actual sales during the first two years following
Bausch & Lombs commercialization exceed agreed-upon forecasted amounts. Pharmos agreed
to pay up to $3.75 million of the costs of developing Zylet, of which $600,000 was deducted from
the purchase price paid by Bausch & Lomb in October 2001. In July 2003, another $1.57 million
was paid to Bausch & Lomb. As of December 31, 2004 and 2003, Pharmos owed an additional $1.56
million as its share of these research and development related Zylet expenses, which is included
in accounts payable and represented the final amount Pharmos owes Bausch & Lomb for their project
development under the terms of the agreement. This amount was paid to Bausch & Lomb in January 2005.
Pharmos paid Dr. Nicholas Bodor, the loteprednol etabonate patent owner and licensor, who is also a
former director of and consultant to Pharmos, a total of approximately $2.7 million from the initial
proceeds of the sale of Lotemax® and Alrex® in return for his consent to Pharmos
assignment of its rights under the license agreement to Bausch & Lomb ($1.5 million paid at closing
and $1.2 million paid in October 2002). During January 2005, the Company paid Dr. Bodor approximately
$1.3 million per the agreement with respect to Zylet. Pharmos owes Dr. Bodor an additional 14.3%
of any payments the Company may receive from Bausch & Lomb in the event that certain sales levels
are exceeded in the first two years following commencement of sales in the U.S. In February 2005,
the Company paid the Israel-U.S. Binational Industrial Research and Development Foundation $211,712,
which represented the maximum amount the Company owed the foundation for Zylet.
Patents, Proprietary Rights and Licenses
Patents and Proprietary Rights
Proprietary protection generally has been important in the pharmaceutical industry, and the commercial
success of products incorporating Pharmos technologies may depend, in part, upon the ability
to obtain strong patent protection.
Some of the technologies underlying Pharmos potential products were invented by or are owned
by various third parties, including the Hebrew University of Jerusalem. Pharmos is the licensee of
these technologies under patents held by the applicable owner, through licenses that generally remain
in effect for the life of the applicable patent. Pharmos generally maintains, at its expense, U.S.
and foreign patent rights with respect to both the licensed technology and its own technology and
files and/or prosecutes the relevant patent applications in the U.S. and foreign countries. Pharmos
also relies upon trade secrets, know-how, continuing technological innovations and licensing opportunities
to develop its competitive position. Pharmos policy is to protect its technology by, among
other things, filing, or requiring the applicable licensor to file, patent applications for technology
that it considers important to the development of its business. Pharmos intends to file additional
patent applications, when appropriate, relating to its technology, improvements to its technology
and to specific products it develops.
The patent positions of pharmaceutical firms, including Pharmos, are uncertain and involve complex
factual questions. In addition, the coverage claimed in a patent application can be significantly
reduced before or after the patent is issued. Consequently, Pharmos does not know whether any of
the pending patent
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|9
|-



|applications underlying the licensed technology will result in the issuance of patents or, if any patents
are issued, whether they will provide significant proprietary protection or will be circumvented
or invalidated. Since patent applications in the U.S. and elsewhere publish only 18 months after
priority date, and since publication of discoveries in the scientific or patent literature often
lag behind actual discoveries, Pharmos cannot be certain that it or its licensors, as the case may
be, were the first creators of inventions covered by pending and issued patents or that it or its
licensors, as the case may be, were the first to file patent applications for such inventions. Moreover,
it may be necessary for Pharmos to participate in interference proceedings declared by the U.S. Patent
and Trademark Office in order to determine priority of invention. Involvement in these proceedings
could result in substantial cost to Pharmos, even if the eventual outcomes are favorable to Pharmos.
Because the results of the judicial process are often uncertain, we cannot be certain that a court
of competent jurisdiction will uphold the patents, if issued, relating to the licensed technology,
or that a competitors product will be found to infringe those patents.
Other pharmaceutical and drug delivery companies and research and academic institutions may have filed
patent applications or received patents in Pharmos fields. If patents are issued to other companies
that contain competitive or conflicting claims and those claims are ultimately determined to be valid,
it is possible that Pharmos would not be able to obtain licenses to these patents at a reasonable
cost or be able to develop or obtain alternative technology.
Pharmos also relies upon trade secret protection for its confidential and proprietary information.
It is always possible that others will independently develop substantially equivalent proprietary
information and techniques or otherwise gain access to Pharmos trade secrets.
It is Pharmos policy to require its employees, consultants, outside scientific collaborators,
sponsored researchers and other advisors to execute confidentiality agreements upon the commencement
of employment or consulting or advisory relationships with Pharmos. These agreements generally provide
that all confidential information developed or made known to the individual during the course of
the individuals relationship with Pharmos is to be kept confidential and not disclosed to third
parties except in specific circumstances. Further, these agreements provide for the maintenance of
confidentiality following the termination of the individuals relationship with Pharmos. In
the case of employees and certain consultants, the agreements provide that all inventions conceived
by the individual in the course of their employment or consulting relationship shall be the exclusive
property of Pharmos. Due to the vital nature of trade secrets and the often uncertain results of
the judicial process, we cannot be sure, however, that these agreements will provide meaningful protection
or adequate remedies for Pharmos trade secrets in the event of unauthorized use or disclosure
of such information. Pharmos patents and licenses underlying its potential products described
herein are summarized below.
Neuroprotective Agents. Pharmos has licensed from the Hebrew University of Jerusalem, which is the
academic affiliation of the inventor, Dr. Raphael Mechoulam, patents covering new cannabinoid compounds
that have demonstrated beneficial activity which may prevent damage or death to nerve cells resulting
from various diseases and disorders of the nervous system while appearing to be devoid of most of
the deleterious side effects usually associated with this class of compounds. Several patents have
been designed to protect this family of compounds and their uses devised by inventors at Pharmos
and the inventors at the Hebrew University. The earliest patent applications resulted in patents
issued in 1989, and the most recent patents date from 2004. These patents cover dexanabinol, which
is under development for the treatment of post-operative cognitive impairment and other conditions,
and new molecules discovered by modifying the chemical structure of dexanabinol.
Anti-inflammatory and Analgesic Agents. Pharmos has also licensed, from the Hebrew University of Jerusalem,
patents for inventions of Dr. Mechoulam covering new compounds that have demonstrated beneficial
activity, which may be effective in treating not only neurological disorders, but also inflammatory
diseases, and most importantly, pain. These bicyclic compounds are expected to cause less adverse
deleterious side effects usually associated with cannabinoids. Several patents have been designed
to protect this family of compounds and their uses by inventors at Pharmos and Hebrew University.
The earliest patent applications resulted in patents issued in 1995, and the most recent patent dates
from 2004.
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|10
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|Emulsion-based Drug Delivery Systems. In the general category of SubMicron Emulsion technology, Pharmos
holds a license to one family of patents from the Hebrew University of Jerusalem and has filed ten
independent patent families of applications including more than ninety patent applications that are
at different stages of prosecution. These patents and patent applications have been devised to protect
a group of formulation technologies devised by Pharmos and the inventors as they relate to pharmaceutical
and medicinal products. The earliest patent filings for SubMicron Emulsion technology date from 1993
and the most recent are dated from 2004. These patents cover a broad range of new formulations, which
improve the absorption of drugs that are poorly soluble in water.
Licenses
As discussed above, Pharmos has licensed patents covering neuroprotective agents and certain emulsion-based
drug delivery systems from the Hebrew University of Jerusalem.
Pharmos subsidiary, Pharmos Ltd., licensed its patents related to the oral delivery of lipophilic
substances in the limited field of use of nutraceuticals to Herbamed, Ltd., a company in Israel controlled
by the Chairman and Chief Executive Officer of Pharmos. The terms of the license agreement are discussed
in Item 13. Certain Relationships and Related Transactions.
Site-Specific Drugs.  In the general category of site-specific drugs that are active mainly in
the eye and have limited systemic side effects, Pharmos licensed several patents from Dr. Nicholas
Bodor. It assigned its rights under the Bodor license to Bausch & Lomb in connection with its
sale of its ophthalmic business. The earliest patents date from 1984 and the most recent from 1996.
Some of these patents cover loteprednol etabonate-based products and its formulations.
Government Regulation
FDA and Comparable Authorities in Other Countries
Regulation by governmental authorities in the U.S. and other countries is a significant factor in our
ongoing research and development activities and in the production and marketing of our products.
Pharmaceutical products intended for therapeutic use in humans are governed in the U.S. by the Federal
Food, Drug and Cosmetic Act (21 U.S.C. § 321 et seq.) and by FDA regulations and by comparable agency regulations in other countries. Specifically, in
order to undertake clinical tests, and to produce and market products for human therapeutic or diagnostic
use, mandatory procedures and safety standards established by the FDA and Department of Health and
Human Services in the U.S. and comparable agencies in other countries must be implemented and followed.
These standards include protection of human research subjects.
The following is an overview of the steps that must be followed before a drug product may be marketed
lawfully in the U.S.:
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             

| | (i)   | Preclinical studies including pharmacology, laboratory evaluation and animal studies to test for initial
  safety and efficacy;                 
| | ----- | ------------------------------------------------------------------------------------------------------------------------------------------------
| |       |                                                                                                                                                 
| | (ii)  | Submission to the FDA of an Investigational New Drug (IND) Application, which must become effective
  before human clinical trials may commence;
| |       |                                                                                                                                                 
| | (iii) | Adequate and well-controlled human clinical trials to establish the safety and efficacy of the drug
  in its intended application;              
| |       |                                                                                                                                                 
| | (iv)  | Submission to the FDA of a New Drug Application (NDA), which application is not automatically accepted
  by the FDA for consideration; and      
| |       |                                                                                                                                                 
| | (v)   | FDA approval of the New Drug Application prior to any commercial sale or shipment of the drug.                                                  

|11
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|In addition to obtaining FDA approval for each product, each drug-manufacturing establishment must
be registered or licensed by the FDA for each product sold within the US that is manufactured at
that facility. Manufacturing establishments are subject to inspections by the FDA and by other national
and local agencies and must comply with current Good Manufacturing Practices (cGMPs), requirements
that are applicable to the manufacture of pharmaceutical drug products and their components.
Preclinical studies include laboratory evaluation of product chemistry and animal studies to assess
the potential safety and efficacy of the product and its formulation. The results of the preclinical
studies are submitted to the FDA as part of an IND, and unless the FDA objects, the application will
become effective 30 days following its receipt by the FDA. If the potential of addiction is found
in the animal tests, then additional regulatory requirements may be imposed by the FDA and DEA.
Clinical trials involve the administration of the drug to healthy volunteers as well as to patients
under the supervision of a qualified principal investigator, who is a medical doctor.
Clinical trials in humans are necessary because effectiveness in humans may not always be gleaned
from findings of effectiveness in animals. They are conducted in accordance with protocols that detail
the objectives of the study, the parameters to be used to monitor safety and the efficacy criteria
to be evaluated. Each protocol is submitted to the FDA as part of the application. Each clinical
study is approved and monitored by an independent Institutional Review Board (IRB) (Ethics Committee)
at each clinical site. The IRB must consider, among other things, the process of obtaining the informed
consents of each study subject, the safety of human subjects, the possible liability of the institution
conducting a clinical study, as well as various ethical factors.
Clinical trials typically are conducted in three sequential phases, although the phases may overlap.
In Phase I, the initial introduction of the drug to humans, the drug is tested in a small group of
healthy volunteers for safety and clinical pharmacology such as metabolism and tolerance. Phase I
trials may also yield preliminary information about the products effectiveness and dosage levels.
Phase II involves detailed evaluation of safety and efficacy of the drug in patients with the disease
or condition being studied. It also involves a determination of optimal dosage and identification
of possible side effects in a larger patient group. Phase III trials consist of larger scale evaluation
of safety and efficacy and usually require greater patient numbers and multiple clinical trial sites,
depending on the clinical indications for which marketing approval is sought.
The process of completing clinical testing and obtaining FDA approval for a new product is likely to
take a number of years and requires the expenditure of substantial resources. The FDA may grant an
unconditional approval of a drug for a particular indication or may grant approval conditioned on
further post-marketing testing. The FDA also may conclude that the submission is not adequate to
support an approval and may require further clinical and preclinical testing, re-submission of the
New Drug Application, and further review. Even after initial FDA approval has been obtained, further
studies may be required to provide additional data on safety or to gain approval for the use of a
product for clinical indications other than those for which the product was approved initially. This
could delay the NDA approval process.
The 1962 amendments to the Federal Food, Drug and Cosmetic Act required for the first time that drug
effectiveness be proven by adequate and well-controlled clinical trials. The FDA interpretation of
that requirement is that at least two such trials are necessary to demonstrate effectiveness for
approval of an NDA. This interpretation is based on the scientific need for independent substantiation
of study results. However, Section 115 of FDAMA revised Section 505 of the Act to read, in pertinent
part that based on relevant science, data from one adequate and well-controlled clinical investigation
and confirmatory evidence  are sufficient to establish effectiveness. The FDA has
not issued comprehensive standards of testing conditions for pivotal trials. The FDA has interpreted
this language for approval based on a single persuasive trial to be limited to special cases including
life-threatening diseases where no effective therapy exists. The FDA still maintains a preference
for at least two adequate and well-controlled clinical trials. Dexanabinol has been shown to be devoid
of psychotropic properties, and Pharmos believes that the potential of addictive properties is remote.
However, because dexanabinol is a cannabinoid, the Company will conduct a test to specifically evaluate
any addictive potential. If the test shows the possibility of
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------------------------

|12
|--



|addiction, additional regulatory requirements would have to be met which could delay the NDA approval
process.
Pharmos products will be subject to foreign regulatory approval before they may be marketed abroad.
Marketing beyond the US is subject to regulatory requirements that vary widely from country to country.
In the European Union, the general trend has been towards coordination of the common standards for
clinical testing of new drugs. Centralized approval in the European Union is coordinated through
the European Medicines Evaluation Agency (EMEA). The time required to obtain regulatory approval
from comparable regulatory agencies in each country may be longer or shorter than that required for
FDA or EMEA approval. Further, in certain markets, reimbursement may be subject to governmentally
mandated prices.
Corporate History
Pharmos Corporation, (formerly known as Pharmatec, Inc.) a Nevada corporation, was incorporated under
the laws of the State of Nevada on December 20, 1982. On October 29, 1992, Pharmatec, the Nevada
Corporation, completed a merger with a privately held New York corporation known as Pharmos Corporation
founded by Dr. Aviv (the name of the post-merger Nevada corporation was changed to Pharmos Corporation).
Human Resources
As of January 19, 2005, Pharmos had 66 employees (56 full-time and 9 part-time), including 12 in the
U.S. (1 part-time) and 54 in Israel (8 part-time). Of the 66 employees, 26 hold doctorate or medical
degrees.
Pharmos employees are not covered by a collective bargaining agreement. To date, Pharmos has
not experienced employment-related work stoppages and considers its employee relations to be excellent.
Public Funding and Grants
Pharmos subsidiary, Pharmos Ltd., has received certain funding from the Chief Scientist of the
Israel Ministry of Industry and Trade (the Chief Scientist) for: (1) research and development of
dexanabinol; (2) SubMicron Emulsion technology for injection and nutrition; (3) research relating
to pilocarpine, dexamethasone and ophthalmic formulations for dry eyes; (4) research and development
of CB2. As of December 31, 2004 the total amounts received under such grants amounted to $13,408,461.
Aggregate future royalty payments related to sales of products developed, if any, as a result of
the grants are limited to $11,706,686 based on grants received through December 31, 2004. Pharmos
will be required to pay royalties to the Chief Scientist ranging from 3% to 5% of product sales,
if any, as a result of the research activities conducted with such funds. Aggregate royalty payments
per product are limited to the amount of funding received to develop that product and interest. Additionally,
funding by the Chief Scientist places certain legal restrictions on the transfer of know-how and
the manufacture of resulting products outside of Israel. See Conditions in Israel.
Pharmos received funding of $925,780 from the Israel-U.S. Binational Industrial Research and Development
Foundation to develop Lotemax® and Zylet. Bausch & Lomb received approval from the FDA for
Zylet in December 2004. In February 2005, the Company paid the foundation $211,712, which represented
the maximum amount the Company owed the foundation.
Pharmos signed an agreement with the Consortium Magnet, operated by the Office of the Chief Scientist,
for developing generic technologies and for the design and development of drug and diagnostic kits.
Under such agreement, Pharmos was entitled to a non-refundable grant amounting to approximately 60%
of the actual research and development and equipment expenditures on approved projects. No royalty
obligations were required within the framework. As of December 31, 2004 Pharmos had received grants
totaling $1,659,549 for this program which was completed and closed.
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|13
|--



|During 2004, the Company signed an agreement with Consortium Magnet to develop a supply of water-soluble
prodrugs of lipophilic compounds that improve their bioavailability and biopharmaceutical properties.
Under such agreement the Company is entitled to a non-refundable grant amounting to approximately
60% of actual research and development and equipment expenditures on approved projects. No royalty
obligations are required within the framework. As of December 31, 2004, the Company received grants
totaling $124,527 from this program.
Conditions in Israel
A significant part of Pharmos operations is conducted in Israel through its wholly owned subsidiary,
Pharmos Ltd., and the Company is directly affected by economic, political and military conditions
there.
Since the establishment of the State of Israel in 1948, a number of armed conflicts have taken place
between Israel and its Arab neighbors, as well as incidents of civil unrest. In addition, Israel
and companies doing business with Israel have, in the past, been the subject of an economic boycott.
Although Israel has entered into various agreements with certain Arab countries and the Palestinian
Authority, there has been an increase in the unrest and terrorist activity that began in September
2000 and has continued with varying levels of severity into 2005. The Company does not believe that
the political and security situation has had any material negative impact on our business to date;
however, the situation is volatile, and we cannot be sure that security and political conditions
will have no such effect in the future.
Many of our employees in Israel are obligated to perform military reserve duty. In the event of severe
unrest or other conflict, individuals could be required to serve in the military for extended periods
of time. Our operations could be disrupted by the absence for a significant period of time of some
of our employees due to military service.
Pharmos Ltd. has received funding from the Office of the Chief Scientist of the Israel Ministry of
Industry and Trade relating to various technologies for the design and development of drugs and diagnostic
kits. This funding prohibits the transfer or license of know-how and the manufacture of resulting
products outside of Israel without the permission of the Chief Scientist. Although we believe that
the Chief Scientist does not unreasonably withhold this permission if the request is based upon commercially
justified circumstances and any royalty obligations to the Chief Scientist are sufficiently assured,
the matter is solely within his discretion and we cannot be sure that such consent, if requested,
would be granted upon terms satisfactory to us or granted at all. Without such consent, we would
be unable to manufacture any products developed by this research outside of Israel, which may greatly
restrict any potential revenues from such products.
The Price of the Companys Common Stock may experience volatility
The trading price of the Companys Common Stock could be subject to wide fluctuations in response
to variations in the Companys quarterly operating results, the failure of trial results, the
failure of the Company to bring product to market, conditions in the industry, and the outlook for
the industry as a whole or general market or economic conditions. In addition, in recent years, the
stock market has experienced extreme price and volume fluctuations. These fluctuations have had a
substantial effect on the market prices for many companies, often unrelated to the operating performance
of the specific companies. Such market fluctuations could have a material adverse effect on the market
price for the Companys securities.
NASDAQ Listing
NASDAQ requires Pharmos to maintain a minimum closing bid price of $1.00 per share. If Pharmos trades
for 30 consecutive business days below the applicable minimum closing bid price requirement, NASDAQ
will send a deficiency notice to the Company, advising that it has been afforded a grace period
(180 calendar days for SmallCap Market Companies) to regain compliance with the applicable requirements.
Pharmos, a SmallCap Company, will be afforded an additional 180-day grace period if, upon the expiration
of the first 180-day grace period, the company is able to demonstrate $5,000,000 in stockholders
equity or
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|14
|--



|$50,000,000 in market value of listed securities or $750,000 in net income from continuing operations
for the current fiscal year or two of the previous three fiscal years. If the Companys stock
was delisted, liquidity for the Companys common stock could be significantly decreased which
could reduce the trading price and increase the transaction costs of trading shares of the Companys
common stock.
Availability of SEC Filings
All reports filed by the Company with the SEC are available free of charge via EDGAR through the SEC
website at www.sec.gov. In addition, the public may read and copy materials filed by the Company
with the SEC at the SECs public reference room located at 450 Fifth St., N.W., Washington,
D.C., 20549. The company also provides copies of its Forms 8-K, 10-K, 10-Q, Proxy and Annual Report
at no charge available through its website at www.pharmoscorp.com as soon as reasonably practicable
after filing electronically such material with the SEC. Copies are also available, without charge,
from Pharmos Corporation, 99 Wood Avenue South, Suite 311, Iselin, NJ, 08830.
Item 2. Properties
Pharmos is headquartered in Iselin, New Jersey, where it leases its executive offices and maintains
clinical, regulatory and business development staff. The New Jersey lease expires in 2009. Pharmos
also leases facilities used in the operation of its research, development, pilot manufacturing and
administrative activities in Rehovot, Israel, which expires in 2006. These facilities have been improved
to meet the special requirements necessary for the operation of Pharmos research and development
activities. In the opinion of the management, these facilities are sufficient to meet the current
and anticipated future requirements of Pharmos. In addition, management believes that it has sufficient
ability to renew its present leases related to these facilities or obtain suitable replacement facilities.
The monthly lease obligations for our office space in 2005 are $18,423 for Iselin, New Jersey and
$26,558 for Rehovot, Israel. The approximate square footage for Iselin, New Jersey and Rehovot, Israel
are 10,403 and 21,600, respectively.
Item 3. Legal Proceedings
The Company and three current officers have been named as defendants in several purported shareholder

class action lawsuits alleging violations of federal securities laws. These lawsuits were filed
beginning
in January 2005 and are pending in the U.S. District Court for the District of New Jersey.
These
lawsuits assert claims under Sections 10(b) and 20(a) of the Securities Exchange Act of 1934
and
Rule 10b-5 thereunder on behalf of a class of purchasers of our common stock during the period
from
May 5, 2003 through and including December 17, 2004 (the Class Period). The complaints

allege generally that the defendants knowingly or recklessly made false or misleading statements

during the Class Period regarding the effectiveness of dexanabinol in treating TBI which had the

effect of artificially inflating the price of our shares. The complaints seek unspecified damages.
Management, based on the advise of counsel, believes the complaints are without merit and intends to defend these lawsuits vigorously.

However, we cannot assure you that we will prevail in these actions, and, if the outcome is unfavorable

to Pharmos, our reputation, profitability and share price could be adversely affected.
In addition, a purported shareholder of Pharmos common stock has commenced a derivative action against


certain officers and directors of Pharmos. This lawsuit was commenced in February 2005 in the
U.S.

District Court for the District of New Jersey. It alleges, on behalf of Pharmos (which has
been
named
as a nominal defendant), breaches of fiduciary duty and other State law violations.
The Complaint

seeks unspecified damages. Management, based on the advise of counsel, believes that the derivative action is without
merit, and intends

to take all appropriate action in respect of the derivative action.
Item 4.  Submission of Matters to a Vote of Security Holders
None.
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|15
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|PART II
      Item 5.  Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities
    The Companys Common Stock is traded on the Nasdaq SmallCap Market under the symbol PARS. The following table sets forth the range of high and low bid prices per share for the Common Stock as reported on the NASDAQ National Market System and the Nasdaq SmallCap Market during the periods indicated.
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|                                                                                                                                                                                                                                                                                                                                                                                                                                                    

|Year ended December 31, 2004 |   | HIGH |  |   | LOW  | 
|---------------------------- | - | ---- |  | - | ---- | 
|                             |   |      |  |  
|1st Quarter                  | $ | 4.98 |  | $ | 3.42 | 
|2nd Quarter                  |   | 4.22 |  |   | 2.90 | 
|3rd Quarter                  |   | 4.22 |  |   | 2.30 | 
|4th Quarter                  |   | 4.25 |  |   | 0.93 | 
|                             |   |      |  |   |      | 
|Year ended December 31, 2003 |   | HIGH |  |   | LOW  | 
|                             |   |      |  |  
|1st Quarter                  | $ | 1.25 |  | $ | 0.76 | 
|2nd Quarter                  |   | 2.65 |  |   | 0.50 | 
|3rd Quarter                  |   | 2.95 |  |   | 1.46 | 
|4th Quarter                  |   | 5.02 |  |   | 2.35 | 

|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|The high and low bid prices for the Common Stock during the first quarter of 2005 (through March 4,
2005) were $1.49 and $0.67, respectively. The closing price on March 7, 2005 was $0.81.
The foregoing represents inter-dealer prices, without retail mark-up, mark-down or commission, and
may not necessarily represent actual transactions.
On February 22, 2005, there were approximately 491 record holders of the Common Stock of the Company
and approximately 25,383 beneficial owners of the Common Stock of the Company, based upon the number
of shares of Common Stock held in street name.
The Company has paid no dividends on its Common Stock and does not expect to pay cash dividends in
the foreseeable future. The Company is not under any contractual restriction as to its present or
future ability to pay dividends. The Company currently intends to retain any future earnings to finance
the growth and development of its business.

|16
|--



|Item 6. Selected Financial Data
|-------------------------------
|                               

|                                           | Year Ended December 31, |             
|------------------------------------------ | ----------------------- | ------------
|
|
|
|Revenues                                   |                         |            
|Cost of Goods Sold                        
|(exclusive of depreciation & amortization) |                         |            
|Operating expenses                         |                         | ($19,880,151
|Other (expense), income, net               |                         | (2,532,390  
|Income (Loss) Before Income                |                         |             
|Taxes                                      |                         | (22,412,541 
|Net (Loss) Income                          |                         | (21,967,767 
|Net (loss) income applicable to            |                         |             
|common shareholders                        |                         | ($21,967,767
|
|                                           |                         |             
|                                           |                         |             
|Net (loss) income per share applicable     |                         |             
|to common shareholders  basic             |                         | ($0.24      
|
|                                           |                         |             
|                                           |                         |             
|Net (loss) income per share applicable     |                         |             
|to common shareholders  diluted           |                         | ($0.24      
|                                           |                         |             
|                                           |                         |             
|                                           |                         |             
|
|                                           |                         |             
|Total assets                               | $                       | 57,664,842  
|                                           |                         |             
|                                           |                         |             
|
|Long term obligations                      | $                       | 1,236,451   
|                                           |                         |             
|                                           |                         |             
|
|Cash dividends declared                    |                         |            
|                                           |                         |             
|                                           |                         |             
|Average shares outstanding - basic         |                         | 90,166,789  
|                                           |                         |             
|                                           |                         |             
|Average shares outstanding  diluted       |                         | 90,166,789  
|                                           |                         |             
|                                           |                         |             

|  |                                                                                                                 
|- | ----------------------------------------------------------------------------------------------------------------
|1 | Includes a non cash option and retention award expense of approximately $ 945,652.                              
|  |                                                                                                                 
|2 | Other expenses include a non cash derivative gain of $525,074.                                                  
|  |                                                                                                                 
|3 | Other expenses include a non cash derivative loss of $1,759,184.                                                
|  |                                                                                                                 
|4 | Includes a $16.3 million gain on sale of the ophthalmic product line in October 2001.                           
|  |                                                                                                                 
|5 | Includes a non cash beneficial conversion reversal of $786,000.                                                 
|  |                                                                                                                 
|6 | Includes a non cash beneficial conversion charge of $1.8 million.                                               
|  |                                                                                                                 
|7 | Includes sales of NJ Net Operating Loss in 2004, 2003 and 2002 of $444,744, $227,798 and $215,223, respectively.
|  |                                                                                                                 
|8 | The Company sold its ophthalmic product line in October 2001.                                                   

|17
|--



|Item 7.  Managements Discussion and Analysis of Financial Condition and Results of Operations
This discussion and analysis of our financial condition and results of operations contains forward-looking
statements that involve risks and uncertainties. We have based these forward-looking statements on
our current expectations and projections of future events. Such statements reflect our current views
with respect to future events and are subject to unknown risks, uncertainty and other factors that
may cause results to differ materially from those contemplated in such forward looking statements.
In addition, the following discussion should be read in conjunction with the audited consolidated
financial statements and the related notes thereto included elsewhere in this report.
Executive Summary
For Pharmos, the year ended December 31, 2004 was a period of significant milestones. During the year,
the Company completed two clinical trials with dexanabinol and advanced a second drug candidate,
cannabinor, to late-stage preclinical development. In November 2004, the exploratory Phase IIa trial
of dexanabinol as a preventative agent against CI following CABG surgery was unblinded. A statistically
significant Stroop test was consistent with protection of higher level executive function in the
brain. Pharmos is currently considering the clinical and regulatory aspects of future clinical trials
for this indication. In December, the Phase III dexanabinol for severe TBI trial was unblinded. The
data showed that while the quality of the trial met or exceeded expectations, dexanabinol failed
to demonstrate efficacy for severe TBI in this trial when dexanabinol was administered within six
hours and the clinical outcomes measured at six months.. The TBI program has been discontinued, and
detailed results will be reported to the FDA and published in the scientific literature.
The results for the year ended December 31, 2004 and 2003 were a net loss of $22.0 million and $18.5
million or a loss per share of $0.24 and $0.27, respectively.
Except for 2001, the Company has experienced operating losses every year since inception in funding
the research, development and clinical testing of our drug candidates. As of December 31, 2004, the
Companys accumulated deficit was approximately $143.0 million. The Company expects to incur
additional losses over the next several years as the Companys research and development and
clinical trial programs continue. The Companys ability to achieve profitability, if ever, is
dependent on its ability to develop and obtain regulatory approvals for its product candidates, to
enter into agreements for product development and commercialization with strategic corporate partners
and contract to develop or acquire the capacity to manufacture and sell its products. See Managements
Discussion and Analysis of Financial Condition and Results of Operations  Liquidity and Capital
Resources.
Critical Accounting Policies
The preparation of our consolidated financial statements in conformity with accounting principles generally
accepted in the U.S. requires management to make estimates and assumptions that affect the amounts
reported in our consolidated financial statements and accompanying notes. Future events and their
effects cannot be determined with absolute certainty. Therefore, the determination of estimates requires
the exercise of judgment. Actual results inevitably will differ from those estimates, and such differences
may be material to the financial statements. The listing below is not intended to be a comprehensive
list of all of our accounting policies. The Company considers certain accounting policies related
to the stock-based compensation, tax valuation allowance and asset impairments to be critical policies
due to the estimation process involved in each.
Stock-based compensation
The Company accounts for stock options granted to employees and directors using the intrinsic value
method in accordance with APB Opinion No. 25, Accounting for Stock Issued to Employees,
and its related interpretations. Pursuant to this method, we measure the intrinsic value of the option
on its grant date as the difference between the exercise price of the option and the fair market
value of our stock. We
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|then expense the difference, if any, over the vesting period of the option, on an accelerated basis,
in accordance with FASB Issued Interpretation No. 28, Accounting for Stock Appreciation Rights
and Other Variable Stock Option or Award Plans.
The Company adopted the disclosure-only requirements of SFAS 123, Accounting for Stock-Based
Compensation. If the Company had adopted SFAS 123 to recognize an expense for options granted
to employees and directors under our stock-based compensation plans, our earnings would have been
materially impacted. The impact of this method is disclosed in the notes to the consolidated financial
statements included elsewhere in this Annual Report.
Options issued to non-employees other than directors are accounted for under the fair value method
in accordance with SFAS 123 and EITF Issue No. 96-18, Accounting for Equity Instruments that
are Issued to Other than Employees for Acquiring, or in Conjunction with Selling Goods or Services.
Under the fair value method, compensation cost is measured at the grant date of the option based
on the value of the award using the Black-Scholes method. Compensation cost is periodically remeasured
as the underlying options vest in accordance with EITF Issue No. 96-18 and is recognized over the
service period.
In December 2004, the FASB issued SFAS 123R. This statement is a revision to SFAS 123, supersedes
APB 25, and amends SFAS 95, Statement of Cash Flows. SFAS 123R eliminates the ability
to account for share-based compensation using the intrinsic value method allowed under APB 25 and
requires public companies to recognize such transactions as compensation expense in the statement
of operations based on the fair values of such equity on the date of the grant, with the compensation
expense recognized over the period in which the recipient is required to provide service in exchange
for the equity award. This statement also provides guidance on valuing and expensing these awards,
as well as disclosure requirements of these equity arrangements. This statement is effective for
the first interim reporting period that begins after June 15, 2005, and the Company will adopt
the statement on July 1, 2005. See Recently Issued Accounting Pronouncements.
On September 6, 2004, the Board of Directors approved the Retention Award Agreements and Pharmos entered
into Retention Award Agreements with each of Dr. Haim Aviv, Chairman and Chief Executive Officer,
and Dr. Gad Riesenfeld, President and Chief Operating Officer. The Company granted retention awards
consisting of cash and restricted stock units to Dr. Aviv. The Company granted retention award consisting
of cash and restricted stock to Dr. Riesenfeld (the Awards). One half of the Awards shall
vest or are scheduled to vest and become non-forfeitable on December 31, 2005, and the balance shall
vest and become non-forfeitable on June 30, 2007, subject to certain accelerated vesting provisions.
The fair value of the restricted shares was based on the fair value of the stock on the issuance
date. The aggregate fair value of the restricted stock awards totaled $2 million. For financial reporting
purposes, the cash awards and the fair value of the restricted stock awards, which totaled $2,500,000,
will be expensed pro rata over the vesting periods. Per the Awards, only Dr. Riesenfeld was issued
the restricted stock; Dr. Aviv received restricted stock units.
Impairment of Long-Lived Assets
We review long-lived assets for impairment whenever events or changes in business circumstances indicate
that the carrying amount of the assets may not be fully recoverable or that the useful lives of these
assets are no longer appropriate. Each impairment test is based on a comparison of the undiscounted
cash flow to the recorded value of the asset. Subsequent impairment assessments could result in future
impairment charges. Any impairment charge would result in the reduction in the carrying value of
long-lived assets and would increase our net loss in the period in which the charge arose.
Tax Valuation Allowance
The Company has assessed the likelihood of realizing future taxable income and has determined that
a 100% deferred tax valuation allowance is deemed necessary. In the event the Company were to determine
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|that it would be able to realize its deferred tax asset, an adjustment to the deferred tax asset would
increase income in the period such determination is made.
Results of Operations
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|                                                                                                                                                                                      

| | Years Ended December 31, 2004 and2003
| | -------------------------------------

|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
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|The Company recorded no product sales revenue and cost of sales during 2004 and 2003.
Total operating expenses increased by $3,846,005 or 24%, to $19,880,151 in 2004 from $16,034,146 in
2003. During 2004, the Company increased its resources being allocated to the Phase II trial of dexanabinol
as a preventive agent against cognitive impairment (CI) that can follow coronary surgery
under cardiopulmonary bypass (CS-CPB) operations which the results were ultimately announced in November
2004. Pre-clinical activities for cannabinor increased substantially during the current year
over 2003 in preparation of beginning human clinical trials in 2005. The Company incurred higher
consulting and professional fees in connection with an increase in accounting fees, including Sarbanes-Oxley
compliance, legal services, amortization of deferred compensation from the Retention Award Agreements
to two executives, and non-cash stock option charges in 2004. In 2004, the Company incurred a decrease
in costs for the Phase III clinical trial of dexanabinol for severe TBI over 2003 as a result of
the trial being completed and the results announced in December 2004.
The Company considers major research & development projects to be those projects that have reached
at least Phase II level of clinical development. The Companys former lead project was the development
of dexanabinol for the treatment of severe TBI, which completed Phase III testing in the U.S., Europe,
Australia and Israel. During 2004, the gross cost of the TBI project was $9.0 million. Total costs
since the TBI project entered Phase II development in 1996 through December 31, 2004 were $44.4 million.
The principal costs of completing the project include collection and evaluation of the data, production
of the drug substance and drug product, commercial scale-up, and management of the project. In December
2004, the Company announced the results of the Phase III trial. Despite the high quality of data
generated by the investigative sites and a rigorous statistical methodology, no difference between
dexanabinol and placebo could be detected. Despite ongoing review of the data, it is unclear as to
why no effect could be detected. There will be no further trials for TBI, although the Company expects
to incur some costs in 2005 in winding up the project.
In 2004, the Company announced the results of the Phase II trial of dexanabinol as a preventive agent
against the CI that can follow coronary surgery involving CS-CPB that was approved by Israels
Ministry of Health. Although the trial did not achieve its primary statistical endpoint, the Stroop
test achieved a statistically and clinically relevant difference. The results from this trial indicate
that the pre-frontal region of the brain involved in higher cognitive functions may be the most affected
by CI and that dexanabinol may preserve these functions in CS-CPB patients. The data support refocusing
patient assessment more closely on integrative or executive functions rather than on the memory aspects
of cognition. The Company is evaluating the future of this program. During 2004, the gross cost
of patients undergoing CS-CPB was approximately $1.6 million. Total costs since the CS-CPB project
entered Phase II development in 2003 through December 31, 2004 were $2.4 million.
Gross expenses for other research and development projects in early stages of development for 2004
and 2003 were $3,696,477 and $1,553,129, respectively. Total research and development expenses, net
of grants, for 2004 and 2003 were $12,888,657 and $11,632,959, respectively. The Company recorded
research and development grants from the Office of the Chief Scientist of Israels Ministry
of Industry and Trade of $3,446,677 and $3,295,819 during 2004 and 2003, respectively, which reduced
the research and development expenses.
General and administrative expenses increased by $2,667,233, or 71%, to $6,413,803 in 2004 from $3,746,570
in 2003. The Company recorded non-cash charges, which are reflected in the numbers below, of approximately
$517,000 of stock options and $368,000 for the Retention Award Agreements. The majority

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|of the increase in selling, general and administrative expenses is due to higher consultants, professional
fees, insurance, and salaries by $1,179,338, $914,641 and $213,030, and $170,319, respectively in
2004 as compared to 2003. The Company incurred a non cash charge of approximately $445,000 for extending
the stock option exercise period to the Companys former chief financial officer. In addition,
the Company granted stock options to certain key consultants during 2004 which resulted in higher
consulting fees. The higher professional fees in 2004 are attributed to increased accounting fees,
preparation of Sarbanes-Oxley compliance related fees, and personnel recruitment fees. Insurance
renewals were higher reflecting insurance industry trends and increased coverage. The increase in
salaries was attributed to an increase in the amortization of deferred compensation from the Retention
Award Agreements and headcount..
Depreciation and amortization expenses decreased by $76,926, or 12%, from $654,617 in 2003 to $577,691
in 2004. The decrease is due to some fixed assets becoming fully depreciated.
Other expense, net, decreased by $147,127 from $2,679,517 in 2003 to $2,532,390 in 2004. Interest expense
increased by $1,790,321 to $3,705,535 in 2004 from $1,915,214 in 2003. The 2004 interest expense
is based on twelve months of interest associated with the remaining balance of the $21.0 million
September 2003 Convertible Debenture financing as compared to the Debentures being outstanding for
only 3 months in 2003. Due to the volatility of the Companys stock price and the exercise of
warrants, the Company recorded a derivative gain of $525,074 in 2004 as compared to a loss of $1,759,183
in 2003. Interest income decreased by $393,232, or 37%, from $1,051,242 in 2003 to $658,010 in 2004
as a result of a lower average cash balance.
During 2004, 2003 and 2002, the Company recognized royalties of $9,008, $4,355, and $0, respectively,
per the licensing agreement with Herbamed, Ltd, a company controlled by Dr. Haim Aviv, the Companys
CEO.
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|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                

| | Years Ended December 31, 2003 and2002
| | -------------------------------------

|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
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|The Company recorded no product sales revenue and cost of sales during 2003 and 2002.
Total operating expenses decreased by $824,268 or 5%, from $16,858,414 in 2002 to $16,034,146 in 2003.
The decrease in operating expense is primarily due to a reduction in consulting and professional
fees. During 2002, the Company was preparing for the IND application with the FDA, which was ultimately
allowed in February 2003. During 2003, the Company increased expenditures related to the development
of dexanabinol for the treatment of traumatic brain injury and to increased activity in the Companys
cannabinoid program to treat various central nervous system and inflammation-based conditions.
The Company considers major research & development projects to be those projects that have reached
at least Phase II level of clinical development. The Companys major product in this time period
was the development of dexanabinol for the treatment of TBI, which was involved in Phase III testing
in the U.S., Europe, Australia and Israel, and the cognitive impairment that can result from coronary
surgery involving cardiopulmonary bypass operations. During 2003, the gross cost of the TBI project
was $10.6 million. Total costs since the TBI project entered Phase II development in 1996 through
December 31, 2003 were $35.4 million. In mid-March 2004, the Company completed enrollment of U.S.
and international TBI patients. The results of this clinical trial were released in December 2004.
In addition, during 2003, the Company initiated a Phase II trial of dexanabinol as a preventive agent
against CI that can follow coronary surgery involving CS-CPB that was approved by Israels Ministry
of Health. Patient enrollment was completed in July 2004 and the results were announced in November
2004. Gross expenses directly related to this project were approximately $866,000 for the twelve
months ended December 31, 2003.
Gross expenses for other research & development projects in earlier stages of development for the
twelve months of 2003 and 2002 were $1,553,129 and $3,324,882, respectively. Research and development
expenses, net of grants, for 2003 and 2002 were $11,632,959 and $12,337,840, respectively. The company

|21
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|received from the Office of the Chief Scientist of Israels Ministry of Industry and Trade grant
money of $3,295,819 and $2,755,882 during 2003 and 2002, respectively, which reduced the research
and development expenses.
General and administrative expenses decreased by $82,180 or 2%, from $3,828,750 in 2002 to $3,746,570
in 2003. The decrease is due to a reduction in consultant fees, investor relations and professional
fees, which offset higher salaries and benefits, travel and board of director costs.
Depreciation and amortization expenses decreased by $37,207, or 5%, from $691,824 in 2002 to $654,617
in 2003. The decrease is due to some fixed assets becoming fully depreciated.
Other expense, net of interest and other expenses, increased by $2,253,108 from $426,409 in 2002 to
$2,679,517 in 2003. The warrants issued in the March 2003 private placement offering are subject
to the requirements under EITF 00-19 and thus are being accounted for as a liability. The value of
the warrants are being marked to market each reporting period until exercised or expiration. The
charge associated with these warrants amounted to approximately $1.8 million. Additionally, in accordance
with Emerging Issues Task Force Issue No. 98-5, Accounting for Convertible Securities with Beneficial
Conversion Features or Contingently Adjustable Conversion Ratios (BCF), the Company recorded
a charge of $1.8 million which was fully amortized at December 31, 2000 in connection with the issuance
of convertible debt with a favorable conversion feature. In accordance with EITF 00-27, a net credit
of $786,000 was recorded as interest income during the first quarter of 2003 to reverse the BCF previously
recorded which was associated with the remaining balance of the September 2000 Convertible Debenture
offering with a face amount of $3.5 million which was not converted. The lower average cash balance
during 2003 resulted in a decrease in interest income of $268,987. Interest expense increased by
$942,358 due to the $21 million financing of Convertible Debentures completed in September 2003.
During 2003 and 2002, the Company recognized royalties of $4,355 and $0 per the licensing agreement
with Herbamed, Ltd, a company controlled by Dr. Haim Aviv, the Companys CEO.
Liquidity and Capital Resources
Except for 2001, the Company has experienced operating losses every year since inception in funding
the research, development and clinical testing of our drug candidates. As of December 31, 2004, the
Companys accumulated deficit was approximately $143.0 million. During January 2005, the Company
received net proceeds of approximately $9.1 million from Bausch & Lomb for the commercialization
of Zylet. The Company expects to incur additional losses over the next several years as the Companys
research and development and clinical trial programs continue. Although the Company may receive royalty
income from sales of Zylet in future periods, it may not be sufficient to allow the Company to operate
profitably at any time in the foreseeable future. The Companys ability to achieve profitability,
if ever, is dependent on its ability to develop and obtain regulatory approvals for its product candidates,
to enter into agreements for product development and commercialization with strategic corporate partners
and contract to develop or acquire the capacity to manufacture and sell its products. Should the
Company be unable to raise adequate financing in the future, long-term projects will need to be scaled
back or discontinued.
The following table describes the Companys liquidity and financial position on December 31, 2004,
and on December 31, 2003:
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|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             

|                                       | 2004 |   | 2003       | 
|-------------------------------------- | ---- | - | ---------- | 
|
|Working capital                        |      | $ | 46,269,367 | 
|Cash and cash equivalents              |      | $ | 49,014,530 | 
|Short-term convertible debentures, net |      | $ | 4,765,540  | 
|Long-term convertible debentures, net  |      | $ | 0          | 

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|Current working capital position
As of December 31, 2004, the Company had working capital of $46.3 million consisting of current assets
of $55.7 million and current liabilities of $9.4 million. This represents a increase of
$3.9 million from its working capital of $42.3 million on current assets of $62.7 million and current
liabilities of $20.4 million as of December 31, 2003.
Current and future liquidity position
Management believes that cash and cash equivalents of $49.0 million as of December 31, 2004 will be
sufficient to support the Companys continuing operations beyond December 2005. During January
2005, the Company received net proceeds of approximately $9.1 million from Bausch & Lomb for
the commercialization of Zylet. The Company is continuing to actively pursue various funding options,
including additional equity offerings, strategic corporate alliances, business combinations and the
establishment of product related research and development limited partnerships to obtain additional
financing to continue the development of its products and bring them to commercial markets. Should
the Company be unable to raise adequate financing or generate revenue in the future, long-term operations
will need to be scaled back or discontinued.
Cash
At December 31, 2004, cash and cash equivalents totaled $49.0 million. At December 31, 2003 cash and
cash equivalents totaled $49.3 million. During 2004, the Company raised approximately net proceeds
of $20.6 million from the sale of common stock. Also during 2004, the Company received proceeds of
approximately $2.1 million from the exercise of stock option and warrants by employees, former employees,
consultants and warrant holders. This net decrease in cash of approximately $300,000 was attributable
to cash used in the Companys operations and repayment of the September 2003 Convertible Debentures.
During January 2005, the Company received net proceeds of approximately $9.1 million from Bausch
& Lomb for the commercialization of Zylet. The cash, cash equivalents and restricted cash will
be used to finance future growth, capital expenditures and repayment of debt.
As part of the September 2003 financing, the Company received a total of $16.0 million of restricted
cash held in escrow which, will remain in escrow until either the Companys convertible debentures
are converted into common shares of the Company by the investor or by the Company, or such funds
are repaid by the Company or are used to fund acquisition(s) approved by the investors. To date,
approximately $14.2 million of the original $21.0 million in convertible debentures have been repaid.
An additional $2 million has been converted into common shares of the Companys stock.
Operating activities
Net cash used in operating activities for 2004 was $19.7 million compared to $17.2 million for 2003.
The increase is primarily due to the expenditures associated with scale up of dexanabinol synthesis,
preclinical studies on cannabinor and the compliance costs associated with the Sarbanes-Oxley Act.
Capital expenditures
Our capital expenditures for property, plant and equipment for 2004, 2003 and 2002 totaled approximately
$310,000, $117,000 and $566,000 respectively for normal replacements and improvements.
Financing activities
During the third quarter of 2004, the Company completed a private placement to sell common shares to
six investors generating net proceeds of $15.7 million. An aggregate of 5,583,334 shares of common
stock were issued.
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|During the first quarter of 2004, one of the investors from the September 2003 Convertible Debentures
private placement converted a total of $2 million plus interest into 497,662 shares of common stock
of the Company. As part of the escrow agreement, $2 million of restricted cash was released to the
Company during April 2004. As of December 31, 2004, the Company repaid or converted approximately
$16.2 million of the September 2003 Convertible Debentures. The remaining Convertible Debenture balance
of $4.8 million will be repaid in equal monthly installments by March 2005.
In January 2004, the underwriters of the December 2003 public offering exercised their over-allotment
option in full, generating net proceeds of approximately $4.04 million. An aggregate of 1,575,000
shares of Pharmos common stock were issued at a purchase price of $2.75 per share.
During 2004, the Company received proceeds of approximately $2.1 million from the exercise of stock
option and warrants by employees, former employees, consultants and warrant holders.
During 2003, the Company received net proceeds of approximately $44.7 million from the issuance of
stock and exercise of stock options and warrants by employees, former employees, consultants and
warrant holders. The Company also received net proceeds of approximately $19.8 million from the issuance
of convertible debentures.
During 2002, the Company received net proceeds of $21,000 from the issuance of stock through the 2001
Employee Stock Purchase Plan.
Executive stock trading program
During April 2004, Pharmos Corporations President and Chief Operating Officer, Dr. Gad Riesenfeld,
and one of its directors, Dr. Elkan Gamzu, separately adopted pre-arranged stock trading plans in
accordance with guidelines specified by Rule 10b5-1 under the Securities Exchange Act of 1934.
Rule 10b5-1 permits officers and directors of public companies to adopt pre-determined plans for selling
specified amounts of stock. The plans may be entered into only when the director or officer is not
in possession of material, non-public information and may be used to gradually diversify investment
portfolios over a period of time.
During 2004, pursuant to his 10b5-1 Plan, Dr. Riesenfeld sold an aggregate of 154,583 shares, which
he acquired upon the exercise of options and warrants covered by the plan. Having depleted all plan-covered
securities, Dr. Riesenfelds 10b5-1 Plan terminated.
During 2004, pursuant to his 10b5-1 Plan, Dr. Gamzu sold an aggregate of 22,500 shares, which he acquired
upon the exercise of options and warrants covered by the plan. Under the terms of Dr. Gamzus
plan, 52,500 shares, which may be acquired upon the exercise of options covered by the plan, remain
to be sold prior to April 15, 2005, subject to certain conditions. The 52,500 shares remaining under
Dr. Gamzus 10b5-1 Plan represent approximately 55% of the total number of shares, options
and warrants he held as of February 18, 2005.
In October 2001, Bausch & Lomb purchased all rights to the Companys loteprednol etabonate
(LE) ophthalmic product line for cash and assumption of certain ongoing obligations. The Company
received gross proceeds of approximately $25 million in cash for its rights to Lotemax® and
Alrex®, prescription products that are made and marketed by Bausch & Lomb under a 1995 Marketing
Agreement with the Company; in addition, Bausch & Lomb also acquired future extensions of LE
formulations including Zylet, a product that was submitted to the FDA for marketing approval in September
2003. In December 2004, Bausch & Lomb received approval from the FDA of its New Drug Application
for Zylet as an ophthalmic anti-inflammatory/antibiotic combination product. During January 2005,
the Company received gross proceeds of approximately $12.2 million from Bausch & Lomb. An additional
milestone payment of up to $10 million could be paid to the Company to the extent sales of the new
product exceed an agreed-upon
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|24
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|forecast in the first two years. The Company had a passive role as a member of a joint committee overseeing
the development of Zylet and has an obligation to Bausch & Lomb to fund up to a maximum of $3.75
million of the LE-T development cost, of which $600,000 was deducted from the purchase price paid
by Bausch & Lomb to Pharmos in October 2001. In July 2003, the Company paid Bausch & Lomb
$1.57 million of its liability for the development of Zylet. As of December 31, 2004, Pharmos owes
an additional $1.56 million as its share of these research and development related Zylet expenses
and represents the maximum amount Pharmos owes Bausch & Lomb. Pharmos paid Bausch & Lomb
the remaining research and development related expenses in January 2005. The Company incurred transaction
and royalty costs of approximately $2 million. The Company also compensated the LE patent owner approximately
$2.7 million ($1.5 million paid upon closing and $1.2 million paid in October 2002) from the proceeds
of the sale of Lotemax and Alrex in return for his consent to the Companys assignment of its
rights under the license agreement to Bausch & Lomb. During January 2005, the Company paid Dr.
Bodor approximately $1.3 million per the agreement with respect to Zylet. Pharmos owes Dr. Bodor
an additional 14.3% of the payment the Company will receive from Bausch & Lomb in the event that
certain sales levels are exceeded in the first two years following commencement of sales in the U.S.
Private Placement of Convertible Debt
On September 26, 2003, the Company completed a private placement of convertible debentures and warrants
to six institutional investors, generating total gross proceeds of $21.0 million. Five million dollars
of the proceeds was to be used for working capital purposes, and $16.0 million was to be available
to fund acquisitions upon the approval of the investors. The convertible debentures are convertible
into common stock of the Company at a fixed price of $4.04, 205% above the closing bid price of the
stock for the five days preceding the closing date. The debentures, which bear an interest rate of
4%, will be redeemed in 13 substantially equal monthly increments which began March 31, 2004. Amounts
converted into shares of Pharmos common stock will reduce the monthly redemption amount in inverse
order of maturity. The $16.0 million earmarked for acquisition activity will be held in escrow until
used or repaid. In connection with the financing, the Company also issued 5,514,705 three-year warrants
(including 514,705 placement agent warrants) to purchase 5,514,705 shares of common stock at an exercise
price of $2.04 per share. The issuance costs related to the convertible debentures of approximately
$1,229,000 in cash and $434,000 for the value of the placement agent warrants were capitalized and
are being amortized over the life of the debt. The Company calculated the value of the warrants at
the date of the transaction, including the placement agent warrants, being approximately $4,652,877
under the Black-Scholes option-pricing method (assumption: volatility 75%, risk free rate 1.59% and
zero dividend yield). The Company allocated the $21.0 million in gross proceeds between the convertible
debentures and the warrants based on their fair values. The Company is reporting the debt discount
as a direct reduction to the face amount of the debt in accordance with APB 21. The discount will
accrete over the life of the outstanding debentures. The issuance costs allocated to the convertible
debentures are being deferred and amortized to interest expense over the life of the debt. APB 21
also requires the Company to allocate the warrant costs between the convertible debentures and the
transaction warrants. The issuance costs allocated to the warrants were recorded as a debit to additional
paid in capital. During the first quarter of 2004, one of the investors from the September 2003 Convertible
Debentures private placement converted a total of $2 million plus interest. The Company issued 497,662
shares of common stock. As part of the escrow agreement, approximately $1,524,000 of restricted cash was released to the Company.
The financing also addressed a possible concern Nasdaq raised informally, relating to a possible violation
of one of Nasdaqs corporate governance rules. Specifically, Nasdaq expressed a concern that
the May 2003 private placement, when aggregated with Pharmos March 2003 registered private
placement, would have resulted in the possible issuance of more than 20% of Pharmos outstanding
securities at a price less than the applicable fair market value for such shares. Completion of the
$21.0 million convertible debt financing had the effect of resolving any such Nasdaq concerns.
In September 2000, the Company completed a private placement of Convertible Debentures, common stock
and warrants to purchase shares of common stock with institutional investors, generating gross proceeds
of $11 million. The Convertible Debentures, which generated gross proceeds of $8 million, were due
in
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|25
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|February 2002 and carried a 6% interest payable semiannually in cash or common stock. In connection
with the Convertible Debenture, the institutional investors also received warrants for the purchase
of 276,259 common shares with a relative fair value of $725,000. The Convertible Debentures were
convertible into common shares of the Company at the conversion price of $3.83 per share (or 2,088,775
common shares) and were convertible beginning October 31, 2000. Under certain limited anti-dilutive
conditions, the conversion price may change. Until converted into common stock or the outstanding
principal is repaid, the terms of the Convertible Debentures required the Company to deposit $4 million
in an escrow account. The issuance costs related to the Private Placement of approximately $1.4 million
were capitalized and amortized over the life of the debt.
In December 2001, the holders of the Convertible Debentures and the Company agreed to modify the repayment
and conversion terms. The holders of $5.8 million convertible debt (book value on December 31,
2001, including accrued interest) extended the maturity date to June 2003 in exchange for a reduction
in the conversion price from $3.83 to $2.63 for half of the outstanding balance and $ 2.15 for the
other half of the outstanding balance. The convertible debt with a maturity date of June 2003 was
convertible beginning December 31, 2001. The holder of the remaining outstanding debt of $1.9 million
(including accrued interest) changed the maturity date from February 28, 2002 to January 31, 2002
in exchange for lowering the conversion price for the other holders. As the modification was not
significant in accordance with EITF 96-19, the change in the fair value between the original convertible
debt and the modified convertible debt was accreted over the remaining term of the convertible debt
with a corresponding charge to interest expense.
Emerging Issues Task Force Issue No. 98-5, Accounting for Convertible Securities with Beneficial Conversion
Features or Contingently Adjustable Conversion Ratios, require the Company to compute the Beneficial
Conversion Feature (BCF) of the convertible debt from the private placement of September
2000. The BCF must be capitalized and amortized from the closing date until the earliest date that
the investors have the right to convert the debt into common shares. The BCF was computed at approximately
$1.8 million, all of which was amortized and included as interest expense in the year ending December
31, 2000.
Common Stock Transactions
On March 4, 2003, the Company raised $4.3 million from the placement of common stock and warrants.
The private placement offering was completed by issuing 5,058,827 shares of common stock at a price
of $0.85 per share and approximately 1.1 million warrants at an exercise price of $1.25 per share.
Additionally, the remaining balance of the September 2000 Convertible Debenture offering was redeemed
for cash. The original face amount of $3.5 million was redeemed for approximately $4.0 million, which
included accrued and unpaid interest. According to EITF 00-19, the issued warrants meet the
requirements of and are being accounted for as a liability since registered shares must be delivered
upon settlement. The Company calculated the initial value of the warrants, including the placement
agent warrants, being approximately $394,000 under the Black-Scholes option-pricing method (assumption:
volatility 75%, risk free rate 2.88% and zero dividend yield). The value of the warrants is being
marked to market each reporting period as a derivative loss until exercised or expiration and amounted
to $297,955 at December 31, 2004. Upon exercise of each of the warrants, the related liability is
removed by recording an adjustment to additional paid-in-capital. A total of $936,156 was recorded
as a credit to additional paid-in-capital in 2003 as a result of exercises and the recording of the
initial value of the warrants.
On May 30, 2003, the Company completed a private placement to sell common shares and warrants to ten
investors, generating total gross proceeds of $8.0 million. The Company filed a registration statement
with the Securities and Exchange Commission to permit resales of the common stock issued. The private
placement offering was completed by issuing 9,411,765 shares of common stock at a price of $0.85
per share (representing an approximate 20% discount to a ten-day trailing average of the closing
price of the stock ending May 28, 2003) and 3,573,529 warrants at an exercise price of $1.40 per
share, which includes 441,177 placement agent warrants. Issuance costs of approximately $525,000
in cash and $240,000 for the value of the placement agent warrants were recorded as a debit to additional
paid in capital.
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|26
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|In December 2003, the Company completed a public offering. Pharmos sold 10,500,000 common shares at
a purchase price of $2.75 per share for gross proceeds of $28,875,000. The stock was offered in a
firm commitment underwriting pursuant to an existing shelf registration statement. The net proceeds
of this offering to Pharmos were approximately $26.9 million. During January 2004, the underwriters
exercised their over-allotment option in full to purchase an aggregate of 1,575,000 shares of Pharmos common stock at a purchase price of $2.75 per share, less the underwriting discount. Total net proceeds
from the offering, including $4.07 million from the exercise of the over-allotment option, were approximately
$31.0 million.
On August 20, 2004, the Company completed a private placement to sell common shares to six investors,

generating total gross proceeds of $16.75 million. An aggregate of 5,583,334 shares of common stock

were issued utilizing a shelf registration of Pharmos securities declared effective by the

Securities and Exchange Commission in December 2003 and was priced at $3.00 per share. Issuance
costs
of approximately $1,067,000 were recorded as a reduction of additional paid in capital.
On September 6, 2004, the Board of Directors approved the Retention Award Agreements and Pharmos entered
into Retention Award Agreements with each of Dr. Haim Aviv, Chairman and Chief Executive Officer,
and Dr. Gad Riesenfeld, President and Chief Operating Officer. The Company granted retention awards
of $300,000 cash and 379,747 restricted stock units to Dr. Aviv and $200,000 cash and 253,165 shares
of restricted stock to Dr. Riesenfeld (the Awards). One half of the Awards shall vest
or are scheduled to vest and become non-forfeitable on December 31, 2005, and the balance shall vest
and become non-forfeitable on June 30, 2007, subject to certain accelerated vesting provisions. The
fair value of the restricted shares was based on the fair value of the stock on the issuance date.
The aggregate fair value of the restricted stock awards totaled $2 million. For financial reporting
purposes, the cash awards and the fair value of the restricted stock awards, which totaled $2,500,000,
will be expensed pro rata over the vesting periods.
Other
In 2004, 2003 and 2002, the Company sold $3,588,728, $2,096,487 and $5,561,838, respectively, of its
State Net Operating Loss carryforwards under the State of New Jerseys Technology Business Tax
Certificate Transfer Program (the Program). The Program allows qualified technology and biotechnology
businesses in New Jersey to sell unused amounts of net operating loss carryforwards and defined research
and development tax credits for cash. The proceeds from the sale in 2004, 2003 and 2002 were $444,774
$227,798 and $215,223, respectively and such amounts were recorded as a tax benefit in the statements
of operations. The State renews the Program annually and limits the aggregate proceeds to $10,000,000.
We cannot be certain if we will be able to sell any of our remaining or future carryforwards under
the Program.
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|Commitments and Long Term Obligations
|-------------------------------------
|                                     

|                                      | Payments Due by Period |  
|------------------------------------- | ---------------------- | -
|
|Operating Leases                      |                        | $
|Convertible Debentures*               |                        |  
|R&D Commitments                       |                        |  
|Other long-term liabilities reflected |                        |  
|on our balance sheet**                |                        |  
|Other Commitments***                  |                        |  
|                                      |                        |  
|Total                                 |                        | $
|                                      |                        |  

|    |                                                                                                                                                                                                                                      
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|*   | Includes interest expense to be paid in cash and excludes the debt discount                                                                                                                                                          
|    |                                                                                                                                                                                                                                      
|**  | Consists of net severance benefits payable under Israeli law. Because these benefits are paid only upon termination of employment, it is not possible to allocate the liability across future years. The Company has funded $811,926.
|    |                                                                                                                                                                                                                                      
|*** | Represents cash retention bonus given to the CEO and President. Approximately $91,912 has been accrued through December 31, 2004.                                                                                                    

|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|On September 26, 2003, the Company completed a private placement of convertible debentures and warrants
with six institutional investors, generating total gross proceeds of $21.0 million. The convertible
debentures are convertible into common stock of the Company at a fixed price of $4.04, 205% above
the closing bid price of the stock for the five days preceding the closing date. The debentures,
which bear an interest rate of 4%, are being redeemed in 13 equal monthly increments and will be
retired on March 31, 2005. As of December 31, 2004, debentures totaling approximately $16.2 million
were either repaid or converted into common stock of the Company.
The R&D commitments represent scheduled professional fee payments for clinical services relating
to the Phase III clinical study of dexanabinol for severe TBI. One of the clinical service based
agreements totaled $11.1 million and is not committed beyond 2004. From inception through December
31, 2004, the Company has recorded $11.0 million as an expense.
The Company has entered into various employment agreements. The terms of these employment agreements
include one-year renewable terms and do not represent long term commitments of the Company.
Management believes that cash and cash equivalents of $49.0 million as of December 31, 2004, will be
sufficient to support the Companys continuing operations beyond December 2005. The Company
is continuing to actively pursue various funding options, including additional equity offerings,
strategic corporate alliances, business combinations and the establishment of product related research
and development limited partnerships to obtain additional financing to continue the development of
its products and bring them to commercial markets.
The Company has assessed its vulnerability to certain market risks, including interest rate risk associated
with financial instruments included in cash and cash equivalents, currency impact in Israel, and
our convertible debentures. Due to the relatively short-term nature of these investments the Company
has determined that the risks associated with interest rate fluctuations related to these financial
instruments do not pose a material risk to us. The value of the warrant liability is based upon the
Companys stock price, which has historically shown wide fluctuations.

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|New accounting pronouncements
In December 2004, the Financial Accounting Standards Board (FASB) issued Statement of Financial
Accounting Standards (SFAS) No. 153, Exchanges of Nonmonetary Assets (SFAS 153).
SFAS 153 amends Accounting Policy Board (APB) Opinion No. 29 (APB 29), Accounting
for Nonmonetary Transactions. SFAS 153 eliminates the exception from APB 29 for nonmonetary exchanges
of similar productive assets and replaces it with a general exception for exchanges of nonmonetary
assets that do not have a commercial substance. SFAS 153 is effective for nonmonetary asset exchanges
occurring in fiscal periods beginning after June 15, 2005. The adoption of SFAS 153 is not expected
to have a material impact on our consolidated financial position or results of operations.
In December 2004, the FASB issued a revision to SFAS No. 123, Accounting for Stock-Based Compensation
(SFAS 123R). SFAS 123R replaces SFAS 123 and supersedes APB Opinion No. 25, Accounting
for Stock Issued to Employees, and establishes standards for the accounting for transactions in which
an entity exchanges its equity instruments for goods or services. SFAS 123R focuses primarily on
accounting for transactions in which an entity obtains employee services in share-based payment transactions
and is effective as of the beginning of the first reporting period that begins after June 15, 2005
for public entities that do not file as small business issuers. The fair value based method of SFAS
123 is similar in most respects to the fair value based method under SFAS 123R, although the election
of certain methods within the applicable transition rules of SFAS 123R may affect the impact on our
consolidated financial positions or results of operations. For an approximate impact on the 2004
results, please refer to the equity based compensation section under Footnote #3.
In December 2004, the EITF issued EITF Issue No. 04-08, The Effect of Contingently Convertible
Debt on Diluted Earnings per Share (EITF 04-08). EITF 04-08 reflects the Task Forces
conclusion that contingently convertible debt should be included in diluted earnings per share computations
regardless of whether the market price trigger has been met. The adoption of this statement did not impact the Companys financial statement presentation.
In December 2004, the Financial Accounting Standards Board issued a FASB Staff Position (FSP) that
provides accounting guidance on how companies should account for the effects of the American Jobs
Creation Act of 2004 that was signed into law on October 22, 2004. FSP FAS 109-1, Application
of FASB Statement No. 109, Accounting for Income Taxes, to the Tax Deduction on Qualified
Production Activities Provided by the American Jobs Creation Act of 2004, states that the manufacturers
deduction provided for under this legislation should be accounted for as a special deduction instead
of a tax rate change. The FSP may affect how a company accounts for deferred income taxes. The FSP
is effective December 31, 2004. The Company believes that the adoption of this statement will not have a material impact on its financial position.
In March 2004, the Emerging Issues Task Force issued EITF 03-6, Participating Securities and
the Two-Class Method under FASB Statement No. 128. This statement provides additional guidance
on the calculation and disclosure requirements for earnings per share. The FASB concluded in EITF
03-6 that companies with multiple classes of common stock or participating securities, as defined
by SFAS No. 128, calculate and disclose earnings per share based on the two-class method. The adoption
of this statement does not have an impact to the Companys financial statement presentation.
Item 7A. Quantitative and Qualitative Disclosures About Market Risk
We assessed our vulnerability to certain market risks, including interest rate risk associated with
financial instruments included in cash and cash equivalents, restricted cash, and convertible debentures.
Due to the short-term nature of the cash and cash equivalent investments, restricted cash, and the
fixed interest rate on the convertible debt, we have determined that the risks associated with interest
rate fluctuations related to these financial instruments do not pose a material risk to us.
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|Item 8.  Financial Statements and Supplementary Data
The information called for by this Item 8 is included following the Index to Consolidated Financial
Statements contained in this Annual Report on Form 10-K.
Item 9.  Changes in and Disagreements with Accountants on Accounting and Financial Disclosure
None.
Item 9A. Controls and Procedures
Evaluation of Disclosure Controls and Procedures
Our management, with the participation of our principal executive officer and principal financial officer,
has evaluated the effectiveness of the design and operation of our disclosure controls and procedures
(as defined in Rule 13a-15(e) under the Securities Exchange Act of 1934, as amended) as of the end
of the period covered by this annual Report on Form 10-K. Based on this evaluation, our principal
executive officer and principal financial officer concluded that these disclosure controls and procedures
are effective and designed to ensure that the information required to be disclosed in our reports
filed or submitted under the Securities Exchange Act of 1934 is recorded, processed, summarized and
reported within the requisite time periods.
Managements Annual Report on Internal Control Over Financial Reporting
Our management is responsible for establishing and maintaining effective internal control over financial
reporting (as defined in Rule 13a-15(f) under the Securities Exchange Act of 1934, as amended).
A companys internal control over financial reporting is a process designed to provide reasonable
assurance regarding the reliability of financial reporting and the preparation of financial statements
for external purposes in accordance with generally accepted accounting principles. A companys
internal control over financial reporting includes those policies and procedures that (i) pertain
to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions
and dispositions of the assets of the company; (ii) provide reasonable assurance that transactions
are recorded as necessary to permit preparation of financial statements in accordance with generally
accepted accounting principles, and that receipts and expenditures of the company are being made
only in accordance with authorizations of management and directors of the company; and (iii) provide
reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or
disposition of the companys assets that could have a material effect on the financial statements.
Because of its inherent limitations, internal control over financial reporting may not prevent or detect

misstatements. Also, projections of any evaluation of effectiveness to future periods are subject

to the risk that controls may become inadequate because of changes in conditions, or that the degree

of compliance with the policies or procedures may deteriorate.
Our management, including our principal executive officer and principal financial officer, has conducted
an evaluation of the effectiveness of our internal control over financial reporting based on criteria
established in Internal Control  Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). Based on such
evaluation, our management has concluded that the Company maintained effective internal control over
financial reporting as of December 31, 2004.
Our managements assessment of the effectiveness of the Companys internal control over financial
reporting as of December 31, 2004 has been audited by PricewaterhouseCoopers LLP, an independent
registered public accounting firm, as stated in their report which appears herein.
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|30
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|Changes in Internal Control Over Financial Reporting
There was no change in our internal controls over financial reporting (as defined in Rule 13a-15(f)
under the Securities Exchange Act of 1934, as amended) during our last fiscal quarter that has materially affected, or
is reasonably likely to materially affect, our internal control over financial reporting.
Item 9B. Other Information
None.
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|31
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|PART III
Item 10.  Directors and Executive Officers of the Registrant
The directors, officers and key employees of the Company are as follows:
|----------------------------------------------------------------------------------------------------------------------------------------------
|                                                                                                                                              

|Name                                  |  | Age |  | Position                                                
|------------------------------------- |  | --- |  | --------------------------------------------------------
|                                      |  |     |  |                                                         
|Haim Aviv, Ph.D                       |  | 65  |  | Chairman, Chief Executive Officer,                      
|                                      |  |     |  | Chief Scientist and Director                            
|Gad Riesenfeld, Ph.D                  |  | 60  |  | President, Chief Operating Officer                      
|James A. Meer                         |  | 58  |  | Senior Vice President and                               
|                                      |  |     |  | Chief Financial Officer, 
       Secretary and Treasurer
|David Schlachet **                    |  | 59  |  | Director                                                
|Mony Ben Dor*                         |  | 59  |  | Director                                                
|Georges Anthony Marcel, M.D., Ph.D ** |  | 64  |  | Director                                                
|Elkan R. Gamzu, Ph.D **               |  | 62  |  | Director                                                
|Lawrence F. Marshall, M.D             |  | 61  |  | Director                                                

| 
|-
|*

|** | Members
of the Audit Committee
|-- | ------------------------------

|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Haim Aviv, Ph.D., is Chairman, Chief Executive Officer, Chief Scientist and a Director of the Company.
In 1990, he co-founded Pharmos Corporation, a New York corporation (Old Pharmos), which
merged into the Company in October 1992 (the Merger). Dr. Aviv also served as Chairman,
Chief Executive Officer, Chief Scientist and a Director of Old Pharmos prior to the Merger. Dr. Aviv
was the co-founder in 1980 of Savient Pharmaceuticals, Inc., a publicly-traded company engaged
in the development of products using recombinant DNA, its General Manager and Chief Scientist from
1980 to 1985, and a Director and Senior Scientific Consultant until August 1993. Prior to that time,
Dr. Aviv was a professor of molecular biology at the Weizmann Institute of Science. Dr. Aviv is the
principal stockholder of Avitek Ltd. Dr. Aviv is also an officer and/or significant stockholder of
several privately held Israeli biopharmaceutical and venture capital companies. Dr. Aviv is a member
of the Board of Directors of Ben Gurion University at Beer-Sheva, Israel and Yeda Ltd., the commercial
arm of the Weizmann Institute, Rehovot, Israel. Dr. Aviv holds a Ph.D. degree from the Weizmann Institute of Science.
Gad Riesenfeld, Ph.D., was named President in February 1997, and has served as Chief Operating Officer
since March 1995. He served as Executive Vice President from December 1994 to February 1997, Vice
President of Corporate Development and General Manager of Florida Operations from October 1992 to
December 1994, and was employed by Pharmos from March 1992 until the Merger. Prior thereto, he was
engaged in a variety of pharmaceutical and biotechnology business activities relating to the development
and commercialization of intellectual property, primarily in the pharmaceutical and medical fields.
From March 1990 through May 1991, Dr. Riesenfeld was a Managing Director of Kamapharm Ltd., a private
company specializing in human blood products. Prior thereto, from May 1986, he was Managing Director
of Galisar Ltd., a pharmaceutical company involved in extracorporeal blood therapy. Dr. Riesenfeld
holds a Ph.D. degree from the Hebrew University of Jerusalem and held a scientist position, as a
post doctorate, at the Cedars Sinai Medical Center in Los Angeles, California.
James A. Meer was elected Vice President, Chief Financial Officer, Secretary and Treasurer of Pharmos
in July 2004 and in January of 2005 became Senior Vice President, Chief Financial Officer, Secretary
and Treasurer. From November 2000 until his appointment as the Companys Chief Financial Officer,
he was a principal in Meer Healthcare Consulting and GreyPeach Partners serving life science and
technology companies. From 1992 to 2000, Mr. Meer was Vice President and Treasurer of Schein Pharmaceutical,
Inc, (NYSE) a leading specialty pharmaceutical company. In addition, Mr. Meer has held several senior
financial positions with public companies in other industries. He holds an MBA in Finance from Pace
University and a BA in Economics from Rutgers College.

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|David Schlachet, a Director of the Company from December 1994, has been a managing partner of Biocom,
a V.C Fund in the field of Life Science, since April 2000 until December 2004. Prior to that, he
served as Chairman of Elite Industries Ltd from July 1997 until June 2000. From January 1996 to June
1997, Mr. Schlachet served as the Vice President of the Strauss Group and Chief Executive Officer
of Strauss Holdings Ltd, one of Israels largest privately owned food manufacturers. He was
Vice President of Finance and Administration at the Weizmann Institute of Science in Rehovot, Israel
from 1990 to December 1995, and was responsible for the Institutes administration and financial
activities, including personnel, budget and finance, funding, investments, acquisitions and collaboration
with the industrial and business communities. From 1989 to 1990, Mr. Schlachet was President and
Chief Executive Officer of YEDA Research and Development Co. Ltd., a marketing and licensing company
at the Weizmann Institute of Science. As of July 2004, Mr. Schlachet serves as CFO of Syneron Medical
Ltd, a company that develops, manufactures, and markets aesthetic medical products. He also serves
as a Director of Harel Investment House (Israeli broker, underwriter and asset management firm) and
as a Director of Israel Discount Bank Ltd., Hapoalim Capital Markets Ltd, Edgar Ltd. (real estate
company), Proseed Ltd., a Venture Capital investment company, Compugen Ltd. and Taya Investment Company Ltd.
Mony Ben Dor, a director of the Company since September 1997, has been managing partner of Biocom,
a V.C Fund in the field of Life Science since April 2000. Prior to that he was Vice President of
the Israel Corporation Ltd. from May 1997, and Chairman of two publicly traded subsidiaries: H.L.
Finance and Leasing and Albany Bonded International Trade. He was also a Director of a number of
subsidiary companies such as Israel Chemicals Ltd., Zim Shipping Lines, and Tower Semiconductors.
From 1992-1997 Mr. Ben Dor was Vice President of Business Development for Clal Industries Limited,
which is one of the leading investment groups in Israel. He was actively involved in the acquisition
of pharmaceutical companies, including Pharmaceutical Resources Inc., Finetech Ltd. and BioDar Ltd.
He served as a director representing Clal Industries in all of the acquired companies as well as
other companies of Clal Industries. Prior to his position at Clal Industries, Mr. Ben Dor served
as Business Executive at the Eisenberg Group of companies.
Georges Anthony Marcel, M.D., Ph.D., a Director of the Company since September 1998, is founder and
chairman of the Scientific Advisory Board of HealthValue SARL, specialized in biotechnology competitive
intelligence. Previously Dr. Marcel was Chairman & CEO of TMC Development, a biopharmaceutical
consulting firm based in Paris, France. Prior to founding TMC Development in 1992, Dr. Marcel held
a number of senior executive positions in the pharmaceutical industry, including Chief Executive
Officer of Amgens French subsidiary, Vice President of Marketing for Rhone-Poulenc Sante (now
Aventis) and Director of Development for Roussel-Uclaf. Dr. Marcel teaches biotechnology industrial
issues and European regulatory affairs at the Faculties of Pharmacy of Paris and Lille as well as
at Versailles Law School. Dr. Marcel is also a member of the Gene Therapy Advisory Committee at the
French Medicines Agency and sits on the Expert Committee of Genopole.
Elkan R. Gamzu, Ph.D., a Director of the Company since February 2000, is a consultant to the biotechnology
and pharmaceutical industries a Principal of enERGetics Biopharmaceutical Consultancy, LLC, and a
founding partner of the due diligence company BioPharmAnalysis, LLC. From December 1, 2004 until
February 24, 2005, Dr. Gamzu was the interim CEO of XTL Biopharmaceuticals, Ltd. Prior to becoming
a consultant, Dr. Gamzu held a number of senior executive positions in the biotechnology and pharmaceutical
companies, including President and Chief Executive Officer of Cambridge Neuroscience, Inc. from 1994
until 1998. Dr. Gamzu also served as President and Chief Operating Officer and Vice President of
Development for Cambridge Neuroscience, Inc. from 1989 to 1994. Previously, Dr. Gamzu held a variety
of senior positions with Warner-Lambert and Hoffmann-La Roche, Inc. In 2001 and 2002, Dr. Gamzu was
part-time Interim VP, Product Management Leadership for Millennium Pharmaceuticals, Inc. Dr. Gamzu
is a member of the Board of Directors of four other biotechnology companies: the publicly traded
XTL Biopharmaceuticals Ltd. (former interim Chairman of the Board) and the privately held biotechnology
companies Neurotech S.A. of Paris, France and Hypnion, Inc., and NeuroHealing Pharmaceuticals Inc.
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|33
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|Lawrence F. Marshall, M.D., a Director of the Company since June 2002, an internationally recognized
neurosurgeon and opinion leader in the field, is currently Professor and Chair of the Division of
Neurological Surgery at the University of California, San Diego Medical Center. Dr. Marshalls
30-year career as a scientist and neurosurgeon has been at the forefront in the search for new and
better treatment measures to improve patient outcome. He has been a principal investigator or co-investigator
in over two dozen preclinical and clinical trials primarily relating to head and spinal cord injury,
including projects funded by the National Institutes of Health, the Insurance Institute for Highway
Safety, and several large pharmaceutical companies. Results of research undertaken by Dr. Marshall,
which cover a wide range of issues related to TBI and other conditions of the brain, have been published
in dozens of scientific journals. Among the numerous board, committee, editorial and other positions
Dr. Marshall has held or holds are board and committee memberships with the American Brain Injury
Consortium, the National Head Injury Foundation, the American Association of Neurological Surgeons
and the Congress of Neurological Surgeons. Dr. Marshall is the recipient of many distinguished medical
prizes and awards.
Role of the Board; Corporate Governance Matters
It is the paramount duty of the Board of Directors to oversee the Chief Executive Officer and other
senior management in the competent and ethical operation of the Company on a day-to-day basis and
to assure that the long-term interests of the shareholders are being served. To satisfy this duty,
the directors set standards to ensure that the Company is committed to business success through maintenance
of the highest standards of responsibility and ethics.
Members of the Board bring to the Company a wide range of experience, knowledge and judgment. The governance
structure in the Company is designed to be a working structure for principled actions, effective
decision-making and appropriate monitoring of both compliance and performance. The key practices
and procedures of the Board are outlined in the Corporate Governance Code of Ethics and Business
Conduct filed as an exhibit to the 2003 annual report on Form 10-K and are also available on the
Companys website at www.pharmoscorp.com/investors.
Lead Director
In June 2004, the Board created the position of lead director and adopted a Lead Independent Director
Charter, a copy of which will shortly be available on our website at www.pharmos.com. The position of lead director was created for the purpose of assisting the Chairman and the remainder
of the Board in assuring effective corporate governance in managing the affairs of the Board and
the Company. The Board, in accordance with the recommendation of the Governance and Nominating Committee,
designated Mony Ben Dor as lead director, to hold office until the next Annual Meeting of Directors
or until his successor is duly elected and qualified.
Board Committees
The Board has a standing Compensation Committee, Governance and Nominating Committee and Audit Committee.
The Compensation Committee is primarily responsible for reviewing the compensation arrangements for
the Companys executive officers, including the Chief Executive Officer, and for administering
the Companys stock option plans. Members of the Compensation Committee are Messrs. Ben Dor,
Gamzu and Marshall.
The Governance and Nominating Committee, created by the Board in February 2004, assists the Board in
identifying qualified individuals to become directors, determines the composition of the Board and
its committees, monitors the process to assess Board effectiveness and helps develop and implement
the Companys corporate governance guidelines. Members of the Governance and Nominating Committee
are Messrs. Ben Dor, Marcel and Schlachet.
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|34
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|The Audit Committee is primarily responsible for overseeing the services performed by the Companys
independent registered public accounting firm and evaluating the Companys accounting policies
and its system of internal controls. Consistent with the Nasdaq audit committee structure and membership
requirements, the Audit Committee is comprised of three members: Messrs. Gamzu, Marcel and Schlachet,
all of whom are independent directors. While more than one member of the Companys Audit Committee
qualifies as an audit committee financial expert under Item 401(h) of Regulation S-K,
Mr. David Schlachet, the Committee chairperson, is the designated audit committee financial expert.
Mr. Schlachet is considered independent as the term is used in Item 7(d)(3)(iv) of Schedule
14A under the Exchange Act.
The Audit Committee, Compensation Committee and Governance and Nominating Committee each operate under
written charters adopted by the Board. These charters are available on the Companys website
at www.pharmoscorp.com/investors.
Code of Ethics
As part of our system of corporate governance, our Board of Directors adopted a Code of Ethics
and Business Conduct in February 2004 that is applicable to all employees and specifically applicable
to our chief executive officer, president, chief financial officer and controllers. The Code of Ethics
and Business Guidelines are available on the Companys website at www.pharmoscorp.com/investors.
We intend to disclose any changes in or waivers from our Code of Ethics and Business Conduct by filing
a Form 8-K or by posting such information on our website.
Section 16 Filings
No person who, during the fiscal year ended December 31, 2004, was a Reporting Person defined
as a director, officer or beneficial owner of more than ten percent of the Companys Common
Stock which is the only class of securities of the Company registered under Section 12 of the Securities
Exchange Act of 1934 (the Act), failed to file on a timely basis, reports required by
Section 16 of the Act during the most recent fiscal year. The foregoing is based solely upon a review
by the Company of Forms 3 and 4 during the most recent fiscal year as furnished to the Company under
Rule 16a-3(d) under the Act, and Forms 5 and amendments thereto furnished to the Company with respect
to its most recent fiscal year, and any representation received by the Company from any reporting
person that no Form 5 is required.
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

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|Item 11. Executive Compensation
The following table summarizes the total compensation of the Chief Executive Officer of the Company
in 2004 and the two previous years, as well as all other executive officers of the Company who received
compensation in excess of $100,000 for 2004.
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|                                                                                                                                                                                                                                                                                        

|                              | Annual Compensation |      | Long Term Compensation |   |        
|----------------------------- | ------------------- | ---- | ---------------------- | - | -------
|
|
|Haim Aviv, Ph.D               |                     | 2004 |                        | $ | 298,284
|Chairman,Chief Executive      |                     | 2003 |                        | $ | 281,400
|Officer, and Chief Scientist  |                     | 2002 |                        | $ | 289,459
|                              |                     |      |                        |   |        
|Gad Riesenfeld,Ph.D           |                     | 2004 |                        | $ | 249,063
|President and Chief Operating |                     | 2003 |                        | $ | 234,965
|Officer                       |                     | 2002 |                        | $ | 255,157
|                              |                     |      |                        |   |        
|                              |                     |      |                        |   |        
|                              |                     |      |                        |   |        
|James A. Meer                 |                     | 2004 |                        | $ | 110,320
|Senior Vice President, Chief  |                     | 2003 |                        | $ |       
|Financial Officer, Secretary  |                     | 2002 |                        | $ |       
|and Treasurer                 |                     |      |                        |   |        
|                              |                     |      |                        |   |        
|Robert W. Cook                |                     | 2004 |                        | $ | 99,244 
|Executive Vice President,     |                     | 2003 |                        | $ | 222,264
|Chief Financial Officer       |                     | 2002 |                        | $ | 222,264

| | 
| | 

|(1) | Consists of contributions to insurance premiums and car allowance.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
|(2) | Consists of housing allowance, contributions to insurance premiums, car allowance and car expense.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
|    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
|(3) | Mr. Meer joined Pharmos Corporation in July 2004.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
|    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
|(4) | Mr. Cook resigned from Pharmos Corporation in March 2004.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
|(5) | Represents the value at the time of grant of 379,747 restricted stock units awarded to Dr. Aviv pursuant
  to a Retention Award Agreement dated September 6, 2004. Using the closing price of a share of our
  common stock on December 31, 2004, the aggregate value of Dr. Avivs restricted stock units
  would be approximately $539,240. One-half of the restricted stock units are scheduled to vest and
  become non-forfeitable on December 31, 2005, and the balance on June 30, 2007, subject to certain
  accelerated vesting provisions. The shares of common stock underlying the restricted stock units
  have the same dividend rights as our unrestricted common stock.
|    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
|(6) | Represents the value at the time of grant of 253,165 shares of restricted stock awarded to Dr. Riesenfeld
  pursuant to a Retention Award Agreement dated September 6, 2004. Using the closing price of a share
  of our common stock on December 31, 2004, the aggregate value of Dr. Riesenfelds shares of
  restricted stock would be approximately $359,494. One-half of the shares of restricted stock are
  scheduled to vest and become non-forfeitable on December 31, 2005, and the balance on June 30, 2007,
  subject to certain accelerated vesting provisions. The shares of restricted stock have the same dividend
  rights as our unrestricted common stock.          
|    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
|(7) | Consists of (i) $300,000 awarded to Dr. Aviv pursuant to a Retention Award Agreement dated September
  6, 2004 (one-half of the cash award is scheduled to vest and become non-forfeitable on December 31,
  2005, and the balance on June 30, 2007, subject to certain accelerated vesting provisions) and (ii)
  $15,821 in deferred payment obligations of the Company equal to the cost of premiums that would otherwise
  have been payable to maintain a split dollar life insurance policy.                                                                                                                                                                                     
|    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
|(8) | Consists of deferred payment obligations of the Company equal to the cost of premiums that would otherwise have been payable to maintain a split dollar life insurance policy.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
|    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
|(9) | Consists of (i) $200,000 awarded to Dr. Riesenfeld pursuant to a Retention Award Agreement dated September 6, 2004 (one-half of the cash award is scheduled to vest and become non-forfeitable on December 31, 2005, and the balance on June 30, 2007, subject to certain accelerated vesting provisions)                                                                                                                                                                                                                                                                                                                                                                              

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|and (ii) $15,181 in deferred payment obligations of the Company equal to the cost of premiums that
would otherwise have been payable to maintain a split dollar life insurance policy.
The following tables set forth information with respect to the named executive officers concerning
the grant and exercise of options during the last fiscal year and unexercised options held as of
the end of the fiscal year.
Option Grants for the Year Ended December 31, 2004
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                         

|                     |  | Common 
      Stock
      Underlying
      Options
      Granted |         |  | % of Total
      Options
      Granted
      to
      Employees |    |   | Exercise
      Price
      per
    Share |      | Expiration 
    Date |  |           | Potential Realizable Value at 
      Assumed Annual Rates of Stock 
      Price Appreciation for Option
    Term |  
|-------------------- |  | ---------------------------------------------------------------- | ------- |  | --------------------------------------------------------------- | -- | - | ---------------------------------------- | ---- | -------------------- |  | --------- | ---------------------------------------------------------------------------------------------------------------- | -
|                     |  |                                                                  |         |  |                                                                 |    |   |                                          |      |                      | 
|                     |  |                                                                  |         |  |                                                                 |    |   |                                          |      |                      |  |           |                                                                                                                  |  
|                     |  |                                                                  |         |  |                                                                 |    |   |                                          |      |                      |  |          
|Haim Aviv, Ph.D      |  |                                                                  | 190,000 |  |                                                                 | 16 | % | $                                        | 4.24 |                      |  | 12-Feb-14 |                                                                                                                  | $
|Gad Riesenfeld, Ph.D |  |                                                                  | 135,000 |  |                                                                 | 12 | % | $                                        | 4.24 |                      |  | 12-Feb-14 |                                                                                                                  | $
|James A. Meer**      |  |                                                                  | 150,000 |  |                                                                 | 13 | % | $                                        | 3.50 |                      |  | 12-Jul-14 |                                                                                                                  | $
|Robert W. Cook*      |  |                                                                  | 115,000 |  |                                                                 | 10 | % | $                                        | 4.24 |                      |  | 12-Feb-14 |                                                                                                                  | $

|   |                                                          
|-- | ---------------------------------------------------------
|** | Mr. Meer joined Pharmos Corporation in July 2004.        
|   |                                                          
|*  | Mr. Cook resigned from Pharmos Corporation in March 2004.
|   |                                                          

|Aggregated Option Exercises for the Year Ended December 31, 2004 and Option Values as of December 31, 2004:
|-----------------------------------------------------------------------------------------------------------
|                                                                                                           

|                     |  |  | Number of Unexercised
      Options at December 31, 2004 |  | Value of Unexercised In-the-Money Options at
      December 31, 2004 |        
|-------------------- |  |  | -------------------------------------------------------- |  | -------------------------------------------------------------------- | -------
|
|
|
|Haim Aviv, Ph.D      |  |  | 199,376                                                  |  | $                                                                    | 464,690
|Gad Riesenfeld, Ph.D |  |  | 278,020                                                  |  | $                                                                    | 490,635
|James A. Meer**      |  |  |                                                         |  |                                                                      |       
|Robert W. Cook*      |  |  | 178,750                                                  |  | $                                                                    | 305,375

|   |                                                          
|-- | ---------------------------------------------------------
|** | Mr. Meer joined Pharmos Corporation in July 2004.        
|   |                                                          
|*  | Mr. Cook resigned from Pharmos Corporation in March 2004.

|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Stock Option Plans
It is currently the Companys policy that all full time key employees are considered annually
for the possible grant of stock options, depending upon employee performance. The criteria for the
awards are experience, uniqueness of contribution to the Company and level of performance shown during
the year. Stock options are intended to generate greater loyalty to the Company and help make each
employee aware of the importance of the business success of the Company.
As of December 31, 2004, 3,959,967 options to purchase shares of the Companys Common Stock were
outstanding under various option plans, 924,786 of which are non-qualified options. During 2004,
the Company granted 1,387,075 options to purchase shares of its Common Stock to employees, directors
and consultants, of which 456,750 are non-qualified options.

|37
|--



|A summary of the various established stock option plans is as follows:
1992 Plan.   The maximum number of shares of the Companys Common Stock available for issuance
under the 1992 Plan is 750,000 shares, subject to adjustment in the event of stock splits, stock
dividends, mergers, consolidations and the like. Common Stock subject to options granted under the
1992 Plan that expire or terminate would again be available for options to be issued under the 1992
Plan. As of December 31, 2004, there were 60,833 options outstanding to purchase the Companys
Common Stock under this plan. Each option granted which is outstanding under the 1992 plan as of
December 31, 2004 expires on October 31, 2005.
1997 Plan and 2000 Plan.  The 1997 Plan and the 2000 Plan are each administered by a committee appointed by the Board
of Directors (the Compensation Committee). The Compensation Committee will designate
the persons to receive options, the number of shares subject to the options and the terms of the
options, including the option price and the duration of each option, subject to certain limitations.
All stock options grants during 2004 were made from the 2000 Plan. The Company does not plan to issue
any additional options from the 1992 and 1997 Plans.
The maximum number of shares of Common Stock available for issuance under the 1997 Plan is 1,500,000
shares, as amended, and under the 2000 Plan, as amended, is 6,000,000 shares. In 2004, the stockholders
approved increasing the number of shares available in the 2000 Plan by 2.5 million shares. Each plan
is subject to adjustment in the event of stock splits, stock dividends, mergers, consolidations and
the like. Common Stock subject to options granted under the 1997 Plan and the 2000 Plan that expire
or terminate will again be available for options to be issued under each Plan.
The price at which shares of Common Stock may be purchased upon exercise of an incentive stock option
must be at least 100% of the fair market value of Common Stock on the date the option is granted
(or at least 110% of fair market value in the case of a person holding more than 10% of the outstanding
shares of Common Stock (a 10% Stockholder)).
The aggregate fair market value (determined at the time the option is granted) of Common Stock with
respect to which incentive stock options are exercisable for the first time in any calendar year
by an optionee under the 1997 Plan, the 2000 Plan or any other plan of the Company or a subsidiary,
shall not exceed $100,000. The Compensation Committee will fix the time or times when, and the extent
to which, an option is exercisable, provided that no option will be exercisable earlier than one
year or later than ten years after the date of grant (or five years in the case of a 10% Stockholder).
The option price is payable in cash or by check to the Company. However, the Board of Directors may
grant a loan to an employee, other than an executive officer, pursuant to the loan provision of the
1997 Plan or the 2000 Plan, for the purpose of exercising an option or may permit the option price
to be paid in shares of Common Stock at the then current fair market value, as defined in the 1997
Plan or the 2000 Plan.
Under the 1997 Plan, upon termination of an optionees employment or consultancy, all options
held by such optionee will terminate, except that any option that was exercisable on the date employment
or consultancy terminated may, to the extent then exercisable, be exercised within three months thereafter
(or one year thereafter if the termination is the result of permanent and total disability of the
holder), and except such three month period may be extended by the Compensation Committee in its
discretion. If an optionee dies while he is an employee or a consultant or during such three-month
period, the option may be exercised within one year after death by the decedents estate or
his legatees or distributees, but only to the extent exercisable at the time of death. The 2000 Plan
provides that the Compensation Committee may in its discretion determine when any particular stock
option shall expire. A stock option agreement may provide for expiration prior to the end of its
term in the event of the termination of the optionees service to the Company or death or any
other circumstances.
The 1997 Plan and the 2000 Plan each provides that outstanding options shall vest and become immediately
exercisable in the event of a sale of the Company, including (i) the sale of more than
75% of the voting power of the Company in a single transaction or a series of transactions, (ii)
the sale of substantially all
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|38
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|assets of the Company, (iii) approval by the stockholders of a reorganization, merger or consolidation,
as a result of which the stockholders of the Company will own less than 50% of the voting power of
the reorganized, merged or consolidated company.
The Board of Directors may amend, suspend or discontinue the 1997 Plan, but it must obtain stockholder
approval to (i) increase the number of shares subject to the 1997 Plan, (ii) change the designation
of the class of persons eligible to receive options, (iii) decrease the price at which options may
be granted, except that the Board may, without stockholder approval accept the surrender of outstanding
options and authorize the granting of new options in substitution therefore specifying a lower exercise
price that is not less than the fair market value of Common Stock on the date the new option is granted,
(iv) remove the administration of the 1997 Plan from the Compensation Committee, (v) render any member
of the Compensation Committee eligible to receive an option under the 1997 Plan while serving thereon,
or (vi) amend the 1997 Plan in such a manner that options issued under it intend to be incentive
stock options, fail to meet the requirements of Incentive Stock Options as defined in Section 422 of the Code.
The Board of Directors may amend, suspend or discontinue the 2000 Plan, but it must obtain stockholder
approval to (i) increase the number of shares subject to the 2000 Plan or (ii) change the designation
of the class of persons eligible to receive options.
In February 2003, the 2000 Plan was amended by the Board of Directors to provide that options to be
granted to those employees of Pharmos or its subsidiary Pharmos Ltd. who are residents of Israel
will be issued to a trustee for their benefit instead of to them directly. This amendment is to afford
recipients more favorable tax treatment under the laws of the State of Israel. Since this change
is not material to the Plan, stockholder approval is not required. In December 2004, the 2000 Plan
was again amended as a result of new taxes laws under the laws of the State of Israel. Since this
change is not material to the Plan, stockholder approval is not required.
Under current federal income tax law, the grant of incentive stock options under the 1997 Plan or the
2000 Plan will not result in any taxable income to the optionee or any deduction for the Company
at the time the options are granted. The optionee recognizes no gain upon the exercise of an option.
However the amount by which the fair market value of Common Stock at the time the option is exercised
exceeds the option price is an item of tax preference of the optionee, which may cause
the optionee to be subject to the alternative minimum tax. If the optionee holds the shares of Common
Stock received on exercise of the option at least one year from the date of exercise and two years
from the date of grant, he will be taxed at the time of sale at long-term capital gains rates, if
any, on the amount by which the proceeds of the sale exceed the option price. If the optionee disposes
of the Common Stock before the required holding period is satisfied, ordinary income will generally
be recognized in an amount equal to the excess of the fair market value of the shares of Common Stock
at the date of exercise over the option price, or, if the disposition is a taxable sale or exchange,
the amount of gain realized on such sale or exchange if that is less. If, as permitted by the 1997
Plan or the 2000 Plan, the Board of Directors permits an optionee to exercise an option by delivering
already owned shares of Common Stock valued at fair market value) the optionee will not recognize
gain as a result of the payment of the option price with such already owned shares. However, if such
shares were acquired pursuant to the previous exercise of an option, and were held less than one
year after acquisition or less than two years from the date of grant, the exchange will constitute
a disqualifying disposition resulting in immediate taxation of the gain on the already owned shares
as ordinary income. It is not clear how the gain will be computed on the disposition of shares acquired
by payment with already owned shares.
2001 Employee Stock Purchase Plan.  The 2001 Plan is intended to qualify as an employee stock purchase plan under Section 423 of
the Code. All employees of the Company, its Pharmos Ltd. subsidiary or any other subsidiaries or
affiliated entities who have completed 180 consecutive days of employment and who customarily work
at least 20 hours per week will be eligible to participate in the 2001 Plan, except for any employee
who owns five percent or more of the total combined voting power or value of all classes of stock
of the Company or any subsidiary on the date a grant of a right to purchase shares under the 2001
Plan (Right) is made. There currently are no such employees with such large holdings. Participation
by officers
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|39
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|in the 2001 Plan will be on the same basis as that of any other employee. No employee will be granted
a Right which permits such employee to purchase shares under the 2001 Plan at a rate which exceeds
$25,000 of fair market value of such shares (determined at the time such Right is granted) for each
calendar year in which such Right is outstanding. Each Right will expire if not exercised by the
date specified in the grant, which date will not exceed 27 months from the date of the grant. Rights
will not be assignable or transferable by a participating employee, other than in accordance with
certain qualified domestic relations orders, as defined in the Code, or by will or the laws of descent
and distribution.
The total number of shares reserved for issuance under the 2001 Plan is 500,000 shares. Under the 2001
Plan, for any given calendar year, a participating employee can only be granted Rights to purchase
that number of shares which, when multiplied by the exercise price of the Rights, does not exceed
more than 10% of the employees base pay. From inception to December 31, 2004, the Company issued
62,796 shares of its common stock through the 2001 Plan. During 2004, the Company issued 9,493 shares
of its common stock through the 2001 Plan.
From time to time, the Board of Directors may fix a date or a series of dates on which the Company
will grant Rights to purchase shares of Common Stock under the 2001 Plan at prices not less than
85% of the lesser of (i) the fair market value of the shares on the date of grant of such Right or
(ii) the fair market value of the shares on the date such Right is exercised.
The 2001 Plan also provides that any shares of Common Stock purchased upon the exercise of Rights cannot
be sold for at least six months following exercise, to avoid potential violations of the short
swing trading provisions of Section 16 of the Securities Exchange Act of 1934, as amended.
The Board of Directors or a committee to which it delegates its authority under the 2001 Plan will
administer, interpret and apply all provisions of the 2001 Plan. The Board has delegated such authority
to the Compensation and Stock Option Committee.
The Board of Directors may amend, modify or terminate the 2001 Plan at any time without notice, provided
that no such amendment, modification or termination may adversely affect any existing Rights of any
participating employee, except that in the case of a participating employee of a foreign subsidiary
of the Company, the 2001 Plan may be varied to conform with local laws. In addition, subject to certain
appropriate adjustments to give effect to relevant changes in the Companys capital stock, no
amendments to the 2001 Plan may be made without stockholder approval if such amendment would increase
the total number of shares offered under the 2001 Plan or would render Rights unqualified
for special tax treatment under the Code.
No taxable income will be recognized by a participant either at the time a Right is granted under the
2001 Plan or at the time the shares are purchased. Instead, tax consequences are generally deferred
until a participant disposes of the shares (e.g., by sale or gift). The federal income tax consequences
of a sale of shares purchased under the 2001 Plan will depend on the length of time the shares are
held after the relevant date of grant and date of exercise, as described below.
If shares purchased under the 2001 Plan are held for more than one year after the date of purchase
and more than two years from the date of grant, the participant generally will have taxable ordinary
income on a sale or gift of the shares to the extent of the lesser of: (i) the amount (if any) by
which the fair market value of the stock at the date of grant exceeds the exercise price paid by
the participant; or (ii) the amount by which the fair market value of the shares on the date of sale
or gift exceeds the exercise price paid by the participant for the shares. In the case of a sale,
any additional gain will be treated as long-term capital gain. If the shares are sold for less than
the purchase price, there will be no ordinary income, and the participant will have a long-term capital
loss for the difference between the purchase price and the sale price.
If the stock is sold or gifted within either one year after the date of purchase or two years after
the date of grant (a disqualifying disposition), the participant generally will have
taxable ordinary income at the time of the sale or gift to the extent that the fair market value
of the stock at the date of exercise was greater than
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|40
|--



|the exercise price.  This amount will be taxable in the year of sale or disposition even if no
gain is realized on the sale, and the Company would be entitled to a corresponding deduction. A capital
gain would be realized upon the sale of the shares to the extent the sale proceeds exceed the fair
market value of those shares on the date of purchase. A capital loss would be realized to the extent
the sales price of the shares disposed of is less than the fair market value of such shares on the
date of purchase. Special tax consequences may follow from dispositions other than a sale or gift.
1997 Employees and Directors Warrants Plan
The 1997 Employees and Directors Warrants Plan was approved by the Stock Option Committee as of February
12, 1997 and March 19, 1997. 1,030,000 Warrants to purchase 1,030,000 shares of Common Stock were
granted to certain employees of the Company. Of such warrants, 955,000 were granted at an exercise
price of $1.59 per share and 75,000 were granted and an exercise price of $1.66 per share (together,
the 1997 Employees Warrants). The 1997 Employees Warrants become exercisable in increments
of 25% each on their first, second, third and fourth anniversaries, respectively, and shall expire
in the year 2007. 100,000 Warrants to purchase 100,000 shares of Common Stock were granted to directors
of the Company at an exercise price of $1.59 per share (the 1997 Directors Warrants)
on February 12, 1997. The 1997 Directors Warrants become exercisable in increments of 25% each on
the first, second, third and fourth anniversaries of February 12, 1997 and shall expire on February
12, 2007. At December 31, 2004, there were 442,500 1997 Employees Warrants at $1.59, no 1997 Employees
Warrants at $1.66 and 5,000 1997 Directors Warrants at $1.59 outstanding.
Upon termination of a Warrant Holders employment, consultancy or affiliation with the Company,
all Warrants held by such Warrant Holder will terminate, except that any Warrant that was exercisable
on the date which the employment, consultancy or affiliation terminated may, to the extent then exercisable,
be exercised within three months thereafter (or one year thereafter if the termination is the result
of permanent and total disability of the holder). If a Warrant Holder dies while he or she is an
employee, consultant or affiliate of the Company, or during such three month period, the Warrant
may be exercised within one year after death by the decedents estate or his legatees or distributees,
but only to the extent exercisable at the time of death.
Employment/Consulting Contracts/Directors Compensation
Haim Aviv, Ph.D.   In April 2001, the Compensation and Stock Option Committee of the Board of Directors recommended,
and the Board approved, a one-year employment/consulting agreement for Dr. Aviv, as Chairman of the
Board and Chief Executive Officer of the Company. Dr. Aviv has agreed to devote a majority of his
business time to the Company and to Pharmos Ltd. The agreement provides for automatic one year renewals
unless either the Company terminates the agreement at least 180 days prior to the scheduled expiration
date during the initial one year term (and 90 days for subsequent terms) or Dr. Aviv terminates the
agreement at least 60 days prior to the scheduled expiration date. Dr. Avivs base compensation
for 2004 and for 2005 was and is $298,284, to be allocated between the Company and Pharmos Ltd..
The Company also agreed to make available for Dr. Avivs benefit following his death, termination
of employment for disability or retirement at the age of at least 62 an amount equal to the cost
of insurance premiums the Company would otherwise have incurred to obtain and maintain a split-dollar
life insurance policy on his life (approximately $10,000 per year, accruing interest at 8% per year).
In addition, the Company agreed to pay, in lieu of contributing to other benefits plans on his behalf,
an amount equal to an aggregate of approximately 21% of his base compensation toward the Management
Insurance Scheme managed by the government of Israel for members of management of Israeli companies.
Dr. Avivs employment agreement also provides that if his employment is terminated within one
year following a change of control, he will receive severance pay of 18 months of base
salary for the then-current year, accelerated vesting of all unvested stock options and extended
exercisability of all stock options until their respective expiration dates. A change of control
involves an acquisition of at least 50% of the voting power of the Companys securities, a change
in at least 51% of the composition of the current Board of Directors, or approval by the Board of
Directors or stockholders of the Company of a transaction
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|41
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|where such change of voting control or composition of the Board would occur, where the Company would
be liquidated or where all or substantially all of its assets would be sold.
If Dr. Avivs employment is terminated by the Company, after notice, other than for a change in
control, death, disability or for cause, as defined in his employment agreement, or if
he terminates his employment within one year of a change in control or otherwise for good reason,
as defined in his employment agreement, he will receive severance pay of 12 months of base salary
for the then-current year, accelerated vesting of all unvested stock options and extended exercisability
of all stock options until their respective expiration dates.
The employment agreement also contains customary confidentiality and non-competition undertakings by
Dr. Aviv.
Gad Riesenfeld, Ph.D. In April 2001, the Compensation and Stock Option Committee of the Board of Directors recommended,
and the Board approved, a one year employment agreement for Dr. Riesenfeld, as full-time President
and Chief Operating Officer of the Company. Dr. Riesenfelds base compensation for 2004 and
2005 was and is $249,063.
The other provisions of Dr. Riesenfelds employment agreement relating to benefits, severance
arrangements, automatic renewal and confidentiality and non-competition obligations are substantially
similar to those included in Dr. Avivs employment agreement, as described above, except that
the Companys contribution to the Management Insurance Scheme on Dr. Riesenfelds
behalf is approximately 16%. In addition, the Compensation Committee and the Board of Directors in
April 2001 also authorized an amendment to Dr. Riesenfelds employment agreement to provide
that if the Company hires a new Chief Executive Officer, Dr. Riesenfeld will be awarded, at the time
of commencement of employment, a one-time stock option grant equal to the highest grant he received
during the previous three years, in addition to his annual stock option awards. In addition, any
termination by the Company within 12 months after such commencement of employment will require 180
days prior written notice to Dr. Riesenfeld and will entitle him to severance pay equal to
12 months of base salary. In such circumstances, any resignation by Dr. Riesenfeld within 12 months
thereafter other than for good reason (as defined in his employment agreement) will require
90 days prior written notice by Dr. Riesenfeld and will entitle him to 12 months of base salary.
The amendment to his employment agreement also provides that Dr. Riesenfeld will act as an unpaid
consultant to the Company for a one year period following any such termination or resignation.
On September 6, 2004, the Board of Directors approved the Retention Award Agreements and Pharmos entered
into Retention Award Agreements with each of Drs. Aviv and Riesenfeld. The Company granted retention
awards of $300,000 cash and 379,747 restricted stock units to Dr. Aviv and $200,000 cash and 253,165
shares of restricted stock to Dr. Riesenfeld (the Awards). One half of the Awards shall vest or are
scheduled to vest and become non-forfeitable on December 31, 2005, and the balance shall vest and
become non-forfeitable on June 30, 2007, subject to certain accelerated vesting provisions. The fair
value of the restricted stock awards was based on the fair value of the underlying stock on the issuance
date. The aggregate fair value of the restricted stock awards totaled $2 million.
James A. Meer. In July 2004, the Compensation and Stock Option Committees of the Board of Directors recommended,
and the Board approved, a one year employment agreement for Mr. Meer as full time Vice President,
Chief Financial Officer, Secretary and Treasurer of the Company. In January 2005, Mr. Meer was promoted
to Senior Vice President, Chief Financial Officer, Secretary and Treasurer. Mr. Meers base
compensation for 2004, effective July 12 was $235,000 and is $235,000 for 2005. The other provisions
of Mr. Meers employment agreement relating to benefits, severance arrangements, automatic renewal
and confidentiality and non-competition obligations are substantially similar to the those included
in Dr. Avivs employment agreement, as described above, except that Mr. Meer does not participate
in the Management Insurance Scheme of Pharmos Ltd. As part of Mr. Meers employment
contract, Mr. Meer is required to have an insurance policy. The Company will reimburse Mr. Meer the
premium payments on his life insurance policy up to $8,000.
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|42
|--



|Directors Compensation. In March 2002, the Board of Directors of the Company adopted a compensation policy with respect to
outside members of the Board which was amended in February 2004 and in June 2004.
Cash Compensation
In February 2004, the Board of Directors adopted the recommendation of the Compensation Committee to
increase Board compensation to two payments of $4,000 each per annum (a total of $8,000), to increase
compensation for attendance at board, committee or shareholder meetings to $1,500 per meeting (only
one payment per day, regardless of the number of meetings attended), to provide for separate additional
payments to members of the Audit Committee of $2,000 per meeting, even if other meetings are held
on the same day, to increase the initial stock option grants for new independent directors to 35,000
options and to increase the annual option grant to such directors to 25,000.
In June 2004, the Board of Directors adopted the recommendation of the Compensation Committee to increase
the cash compensation for the lead director of the Board of Directors to one payment of $25,000 per
annum (to be paid in two installments: $12,500 on January 1 and $12,500 immediately after the Annual
Meeting of the Board) in lieu of all other cash payments other directors receive for serving on the
Board.
Compensation Committee Interlocks and Insider Participation
The members of the Compensation and Stock Option Committee are Mony Ben Dor, Lawrence Marshall, and
Elkan Gamzu. There were no interlocks on the Compensation and Stock Option Committee in 2004.
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|43
|--



|Item 12.  Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
    The following table sets forth certain information with respect to the beneficial ownership of the Companys Common Stock as of February 17, 2005 (unless otherwise indicated), by (i) each person who was known by the Company to own beneficially more than 5% of any class of the Companys Common Stock, (ii) each of the Companys Directors, and (iii) all current Directors and executive officers of the Company as a group. Except as otherwise noted, each person listed below has sole voting and dispositive power with respect to the shares listed next to such persons name.
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         

|Name and Address of
      Beneficial Ownership                                                                                                  |  | Amount of
      Beneficial
      Ownership |   | Percentage of
      Total (1)
|----------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------------------------------------ | - | -----------------------------
|                                                                                                                                                |  |                                            |   |                              
|Haim Aviv, Ph.D. (2)
      c/o Pharmos Ltd.
      Kiryat Weitzman
      Rehovot 76326, Israel                                                   |  | 1,295,635                                  |   | 1.4 %                        
|                                                                                                                                                |  |                                            |   |                              
|David Schlachet (3)
      Syneron Medical Ltd.
      Industrial Zone
      Tavor Building 
      P.O.B. 550 Yokneam Illit,
      20692 Israel   |  | 84,687                                     | * | *                            
|                                                                                                                                                |  |                                            |   |                              
|Mony Ben Dor (3)40 Hakukia St.Rishon Le Zion 75548, Israel                                                                                      |  | 39,687                                     | * | *                            
|                                                                                                                                                |  |                                            |   |                              
|Georges Anthony Marcel M.D., Ph.D.(3)9 ue de Magdebourg75116 Paris, France                                                                      |  | 27,500                                     | * | *                            
|                                                                                                                                                |  |                                            |   |                              
|Elkan R. Gamzu, Ph.D. (3)enERGetics199 Wells Avenue, Suite 302Newton, MA 02459                                                                  |  | 51,250                                     | * | *                            
|                                                                                                                                                |  |                                            |   |                              
|Lawrence F. Marshall, M.D. (3)University of California, San DiegoRegents Court Bldg., Suite 2004130 LaJolla Village DriveLaJolla, CA 92037-1480 |  | 23,750                                     | * | *                            
|                                                                                                                                                |  |                                            |   |                              
|All Directors andExecutive Officers as a group(8 persons)(4)                                                                                    |  | 1,740,008                                  |   | 1.8%                         
|                                                                                                                                                |  |                                            |   |                              
|HYMF Limited (5)Walker House Mary StreetPO Box 908 GTGeorge Town, Grand Cayman (Cayman Islands)                                                 |  | 4,765,099                                  |   | 5.0%                         

|
|

|                                 
|--------------------------------------
|* Indicates ownership of less than 1%.
|                                      

|(1) | Based on 95,137,076 shares of Common Stock outstanding, plus each individuals currently
  exercisable warrants or options. Assumes that no other individual will exercise any warrants and/or
  options.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|    |                                                                                                                                                                                                          
|(2) | Includes of currently exercisable options and warrants to purchase 822,656 shares of Common Stock,
  plus 472,979 shares of Common Stock                                                                 

|44
|--



|(3) | Consists of currently exercisable options and warrants to purchase Common Stock.                                                                                    
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------
|    |                                                                                                                                                                     
|(4) | Based on the number of shares of Common Stock outstanding, plus 1,267,029 currently exercisable warrants
  and options held by the Directors and executive officers.
|    |                                                                                                                                                                     
|(5) | This information is as of December 31, 2004 based on a Form 13G filed by Barclays Global Investors
  NA on February 14, 2005.                                       

|                                                                                                                                                   
|---------------------------------------------------------------------------------------------------------------------------------------------------
|EQUITY COMPENSATION PLAN INFORMATION
The table below provides certain information concerning our equity compensation plans as of December
31, 2004.
|                                                                                                                                                   

|*Plan Category*                                                  |  | Number of securities to be
      issued upon exercise of
      outstanding options,
      warrants and rights |  | Weighted average exercise 
      price of outstanding 
      options, warrants and rights |  | Number of securities
      remaining available for 
      future issuance under equity
      compensation plans
      (excluding securities 
      reflected in column (a))
|---------------------------------------------------------------- |  | ------------------------------------------------------------------------------------------------------------- |  | ----------------------------------------------------------------------------------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|                                                                 |  | (a)                                                                                                           |  | (b)                                                                                       |  | (c)                                                                                                                                                                        
|                                                                 |  |                                                                                                               |  |                                                                                           |  |                                                                                                                                                                            
|Equity compensation plans
      approved by security holders     |  | 4,592,879                                                                                                     |  | $2.79                                                                                     |  | 3,039,916                                                                                                                                                                  
|                                                                 |  |                                                                                                               |  |                                                                                           |  |                                                                                                                                                                            
|Equity compensation plans not
      approved by security holders |  | N/A                                                                                                           |  | N/A                                                                                       |  | N/A                                                                                                                                                                        
|                                                                 |  |                                                                                                               |  |                                                                                           |  |                                                                                                                                                                            
|Total                                                            |  | 4,592,879                                                                                                     |  | $2.79                                                                                     |  | 3,039,916                                                                                                                                                                  

|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Item 13.  Certain Relationships and Related Transactions
The Companys Pharmos Ltd. entered into a License Agreement with Herbamed, Ltd., a company controlled
by Dr. Haim Aviv, the Companys Chairman and Chief Executive Officer. The License Agreement licenses
to Herbamed the Companys patent rights for the oral delivery of lipophilic substances in the
limited field of nutraceuticals, which include food and dietary supplements, food additives, vitamins
and herbs. Under the terms of the revised License Agreement, Herbamed will pay to Pharmos Ltd. royalties
of 6% on net sales of up to $20 million, 5% on net sales between $20 million and $50 million and
4% on net sales in excess of $50 million. During 2004 and 2003, the Company recognized royalties
of $9,008 and $4,355, respectively.
Neither the Company nor its Pharmos Ltd. subsidiary is involved in the field of nutraceuticals generally,
and specifically in developing improved oral delivery of nutraceuticals. Pharmos Ltd., therefore,
licensed its technology in this narrow non-pharmaceutical field of use to Dr. Avivs company
as a way of seeking to benefit from a potential stream of royalty payments without having to devote
any resources to the development of an application it otherwise would not have pursued. In addition,
if the technology proves to be successful for the delivery of nutraceuticals, Pharmos hopes that
it could be able to interest potential strategic partners in licensing the technology for pharmaceuticals
applications.
Dr. Aviv was not involved with either party in negotiating the terms of the License Agreement with
Herbamed. Pharmos Ltd. concluded that the royalty rates and other terms of the License Agreement
are commercially reasonable to it, and the Board of the Company ratified the License Agreement.
In October 2003 and in accordance with provisions of the Sarbanes-Oxley legislation circumscribing
the practice of company loans to executive officers, Pharmos entered into an agreement with Robert
W. Cook, former Executive Vice President and Chief Financial Officer, forgiving the loans made to
him since 2001 used to pay whole life insurance premiums for his benefit and granting
Mr. Cook a special one-time cash bonus of no more than $8,500 in recognition of the fact that such
loan forgiveness resulted in Mr. Cook recognizing additional non-cash taxable income in 2003 of approximately
$21,000. The Company also agreed either to pay directly or reimburse Mr. Cook for future premium
payments on his existing whole

|45
|--



|life insurance policy acquired in 2001 for his benefit by the Corporation and to grant to him
an annual special cash bonus, in addition to his regular annual bonus, sufficient to account for
the tax effects to him of such reimbursement or direct payment by the Corporation; provided that
the sum of such premium payments and special cash bonus in each year does not exceed the aggregate
annual payments previously made by the Company on Mr. Cooks behalf for his split-dollar insurance
policy.
The Herbamed License Agreement was approved by Pharmos Board of Directors and the Cook loan forgiveness
agreements were approved by Pharmos Compensation Committee. Both agreements also were subsequently
ratified by the Audit Committee.
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|46
|--



|Item 14. Principal Accountant Fees and Services
Audit fees
Aggregate fees for professional services rendered by PricewaterhouseCoopers LLP in connection with
its audit of the Companys consolidated financial statements as of and for the years ended December
31, 2004 and 2003, its reviews of the Companys unaudited consolidated interim financial statements,
and for SEC filings were $629,000 and $353,000, respectively.
Audit-related fees
None.
Tax fees
Aggregate fees for professional services rendered by PricewaterhouseCoopers LLP in connection with
its income tax compliance and related tax services for the years ended December 31, 2004, and 2003
were $19,000 and $80,000, respectively.
All other fees
Aggregate fees for professional services rendered by PricewaterhouseCoopers LLP in connection with
its executive compensation analysis for the years ended December 31, 2004, and 2003 were $39,000
and $0, respectively.
Policy on Audit Committee Pre-Approval of Audit and Non-Audit Services of Independent Auditor
The charter of the Audit Committee requires that the Committee review and pre-approve all audit, review
or attest engagements of, and non-audit services to be provided by, the independent registered public accounting firm (other
than with respect to the de minimis exception permitted by the Sarbanes-Oxley Act of 2002 and the
SEC rules promulgated thereunder). The Audit Committee pre-approved all auditing services and permitted
non-audit services rendered by PricewaterhouseCoopers LLP in 2004.
The pre-approval duty may be delegated to one or more designated members of the Audit Committee, with
any such pre-approval reported to the Committee at its next regularly scheduled meeting. Any such
designated member(s) of the Committee shall also have the authority to approve non-audit services
already commenced by the independent  registered public accounting firm if (i) the aggregate amount of all such services provided
constitutes no more than five percent (5%) of the total amount of revenues paid by the Company to
the independent  registered public accounting firm during the fiscal year in which the services are provided, (ii) such services
were not recognized by the Company at the time of the engagement to be non-audit services, and (iii)
such services are promptly brought to the attention of the Committee and approved by such designated
member(s) prior to the completion of the audit.
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|47
|--



|PART IV
Item 15.  Exhibits and Financial Statement Schedules
(a)   Financial Statements and Exhibits
(1)   FINANCIAL STATEMENTS
|-------------------------------------------------------------------------------------------------------------------------------
|                                                                                                                               

| | Report of Independent Registered Public Accounting Firm                                                        
| | ---------------------------------------------------------------------------------------------------------------
| |                                                                                                                
| | Consolidated Balance Sheets at December 31, 2004 and 2003                                                      
| |                                                                                                                
| | Consolidated Statements of Operations for the years ended December 31, 2004, 2003 and 2002                     
| |                                                                                                                
| | Consolidated Statements of Changes in Shareholders Equity for the years ended December 31, 2004, 2003 and 2002
| |                                                                                                                
| | Consolidated Statements of Cash Flows for the years ended December 31, 2004, 2003 and 2002                     
| |                                                                                                                
| | Notes to Consolidated Financial Statements                                                                     

|                                                                                                                                                                                                                                                                                            
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|(2)   FINANCIAL STATEMENT SCHEDULES
        All schedules have been omitted because the information required to be set forth therein is not applicable or is shown in the financial statements or notes thereto.
        (3)   EXHIBITS
        3      Articles of Incorporation and By-Laws
|                                                                                                                                                                                                                                                                                            

| | 3(a) | Restated Articles of Incorporation (Incorporated by reference to Appendix E to the Joint Proxy Statement/Prospectus included in the Form S-4 Registration Statement of the Company dated September 28, 1992 (No. 33-52398) (the Joint Proxy Statement/Prospectus).
| | ---- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |      |                                                                                                                                                                                                                                                                     
| | 3(b) | Certificate of Amendment of Restated Articles of Incorporation dated January 30, 1995 (Incorporated by reference to Annual Report on Form 10-K for the year ended December 31, 1994).                                                                               
| |      |                                                                                                                                                                                                                                                                     
| | 3(c) | Certificate of Amendment of Restated Articles of Incorporation dated January 16, 1998 (Incorporated by reference to the Companys Current Report on Form 8-K, dated February 6, 1998).                                                                              
| |      |                                                                                                                                                                                                                                                                     
| | 3(d) | Certificate of Amendment of Restated Articles of Incorporation dated October 21, 1999 (Incorporated by reference to Form S-3 Registration Statement of the Company dated September 28, 2000 (No. 333-46818).                                                        
| |      |                                                                                                                                                                                                                                                                     
| | 3(e) | Certificate of Amendment of Restated Articles of Incorporation dated July 12, 2002 (Incorporated by reference to Exhibit 3 to the Companys Report on Form 10-Q for the quarter ended June 30, 2002).                                                               
| |      |                                                                                                                                                                                                                                                                     
| | 3(f) | Certificate of Amendment of Restated Articles of Incorporation dated June 30, 2004 (Incorporated by reference to Exhibit 3.1 to the Companys Report on Form 10-Q for the quarter ended June 30, 2004).                                                             
| |      |                                                                                                                                                                                                                                                                     
| | 3(g) | Amended and Restated By-Laws (Incorporated by reference to Exhibit 99.4 to the Companys Current Report on Form 8-K filed on October 24, 2002).                                                                                                                     

|48
|--



|4      Instruments defining the rights of security holders, including
indentures
|--------------------------------------------------------------------------------
|                                                                                

| | 4(a)  | Form of Employee Warrant Agreement, dated April 11, 1995, between the Company and Oculon Corporation
  (Incorporated by reference to the Companys Current Report on Form 8-K, dated April 11, 1995,
  as amended).                                                       
| | ----- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |       |                                                                                                                                                                                                                                                                           
| | 4(b)  | Form of Warrant Agreement dated as of April 30, 1995 between the Company and Charles Stolper (Incorporated
  by reference to Form S-3 Registration Statement of the Company dated November 14, 1995, as amended
  [No. 33-64289]).                                        
| |       |                                                                                                                                                                                                                                                                           
| | 4 (c) | Form of Stock Purchase Warrant dated as of March 31, 1997 between the Company and the Investor (Incorporated
  by reference to Form S-3 Registration Statement of the Company dated March 5, 1998 [No. 333-47359]).                                                       
| |       |                                                                                                                                                                                                                                                                           
| | 4(d)  | Form of Common Stock Purchase Warrant exercisable until September 1, 2005 (Incorporated by reference
  to Exhibit 4.4 to the Companys Current Report on Form 8-K filed on September 11, 2000).                                                                           
| |       |                                                                                                                                                                                                                                                                           
| | 4(e)  | Form of placement agent warrant with Ladenburg Thalmann & Co. Inc. (Incorporated by reference to
  Form S-3 Registration Statement of the Company dated September 28, 2000 (No. 333-46818).                                                                               
| |       |                                                                                                                                                                                                                                                                           
| | 4(f)  | Form of placement agent warrant with SmallCaps OnLine LLC (Incorporated by reference to Form S-3 Registration
  Statement of the Company dated September 28, 2000 (No. 333-46818).                                                                                        
| |       |                                                                                                                                                                                                                                                                           
| | 4(g)  | Form of consulting warrant with SmallCaps OnLine LLC (Incorporated by reference to Form S-3 Registration
  Statement of the Company dated September 28, 2000 (No. 333-46818).                                                                                             
| |       |                                                                                                                                                                                                                                                                           
| | 4(h)  | Certificate of Designation, Rights Preferences and Privileges of Series D Preferred Stock of the Company
  (Incorporated by reference to Exhibit 99.3 to the Companys Current Report on Form 8-K filed
  on October 24, 2002).                                           
| |       |                                                                                                                                                                                                                                                                           
| | 4(i)  | Rights Agreement dated as of October 23, 2002 between the Company and American Stock Transfer &
  Trust Company, as Rights Agent (Incorporated by reference to Exhibit 99.2 to the Companys Current
  Report on Form 8-K filed on October 24, 2002).                     
| |       |                                                                                                                                                                                                                                                                           
| | 4(j)  | Form of Investor Warrant dated March 4, 2003 (Incorporated by reference to Exhibit 99.2 to the Companys
  Current Report on Form 8-K filed on March 4, 2003).                                                                                                            
| |       |                                                                                                                                                                                                                                                                           
| | 4(k)  | Form of Placement Agents Warrant dated March 4, 2003 (Incorporated by reference to Exhibit 99.1
  to the Companys Current Report on Form 8-K filed on March 4, 2003).                                                                                                   
| |       |                                                                                                                                                                                                                                                                           
| | 4(l)  | Registration Rights Agreement dated as of May 30, 2003 between the Company and the purchasers. (Incorporated
  by reference to Exhibit 4.2 to the Companys Current Report on Form 8-K filed on June 3, 2003).                                                            
| |       |                                                                                                                                                                                                                                                                           
| | 4(m)  | Form of Investor Warrant dated June 2, 2003 (Incorporated by reference to Exhibit 4.3 to the Companys
  Current Report on Form 8-K filed on June 3, 2003).                                                                                                               
| |       |                                                                                                                                                                                                                                                                           
| | 4(n)  | Securities Purchase Agreement dated as of September 26, 2003 between the Company and the purchasers
  identified on the signature pages thereto 2003 (Incorporated by reference to Exhibit 4.1 to the Companys
  Current Report on Form 8-K filed on September 30, 2003).
| |       |                                                                                                                                                                                                                                                                           
| | 4(o)  | Form of 4% convertible debenture due March 31, 2005 (Incorporated by reference to Exhibit 4.2 to the
  Companys Current Report on Form 8-K filed on September 30, 2003).                                                                                                 
| |       |                                                                                                                                                                                                                                                                           
| | 4(p)  | Registration Rights Agreement dated as of September 26, 2003 between the Company and the purchasers
  signatory thereto (Incorporated by reference to Exhibit 4.3 to the Companys Current Report
on Form 8-K filed on September 30, 2003).                               

|49
|--



| | 4(q) | Form of Common Stock Purchase Warrant (Incorporated by reference to Exhibit 4.4 to the Companys
  Current Report on Form 8-K filed on September 30, 2003).                                                                                            
| | ---- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |      |                                                                                                                                                                                                                                                        
| | 4(r) | Escrow Agreement dated as of September 26, 2003 between the Company, the purchasers signatory thereto
  and Feldman Weinstein LLP (Incorporated by reference to Exhibit 4.5 to the Companys Current
  Report on Form 8-K filed on September 30, 2003).
| |      |                                                                                                                                                                                                                                                        
| | 4(s) | Form of Placement Agent Common Stock Purchase Warrant (Incorporated by reference to Exhibit 4.6 to
the Companys Current Report on Form 8-K filed on September 30, 2003).                                                                              

|                        
|------------------------
|10    Material Contracts
|                        

| | 10(a)    | Agreement between Avitek Ltd. (Avitek) and Yissum Research Development Company of the Hebrew
  University of Jerusalem (Yissum) dated November 20, 1986 (Incorporated by reference to
  Annual Report on Form 10-K, as amended by Form10-K/A, for year ended December 31, 1992). (1)
| | -------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |          |                                                                                                                                                                                                                                                                                         
| | 10(a)(1) | Supplement to Agreement (Incorporated by reference to Annual Report on Form 10-K, as amended by Form
  10-K/A, for year ended December 31, 1992). (1)                                                                                                                                   
| |          |                                                                                                                                                                                                                                                                                         
| | 10(a)(2) | Hebrew language original executed version of Agreement (Incorporated by reference to Annual Report

on Form 10-K, as amended by Form 10-K/A, for year ended December 31, 1992). (1)                                                                                                     
| |          |                                                                                                                                                                                                                                                                                         
| | 10(b)    | Agreement between Avitek and Yissum dated January 25, 1987 (Incorporated by reference to Annual Report
  on Form 10-K, as amended by Form 10-K/A, for year ended December 31, 1992). (1)                                                                                                
| |          |                                                                                                                                                                                                                                                                                         
| | 10(b)(1) | Schedules and Appendixes to Agreement (Incorporated by reference to Annual Report on Form 10-K, as

amended by Form 10-K/A, for year ended December 31, 1992). (1)                                                                                                                      
| |          |                                                                                                                                                                                                                                                                                         
| | 10(b)(2) | Hebrew language original executed version of Agreement (Incorporated by reference to Annual Report

on Form 10-K, as amended by Form 10-K/A, for year ended December 31, 1992). (1)                                                                                                     
| |          |                                                                                                                                                                                                                                                                                         
| | 10(c)    | Research, Development and License Agreement between Pharmos Ltd., Pharmos Corporation (Old Pharmos)
  and Yissum dated February 5, 1991 (Incorporated by reference to Annual Report on Form 10-K, as amended
  by Form 10-K/A, for year ended December 31, 1992). (1)                 
| |          |                                                                                                                                                                                                                                                                                         
| | 10(c)(1) | Schedules and Appendixes to Agreement (Incorporated by reference to Annual Report on Form 10-K, as

amended by Form 10-K/A, for year ended December 31, 1992). (1)                                                                                                                      
| |          |                                                                                                                                                                                                                                                                                         
| | 10(d)    | 1992 Incentive and Non-Qualified Stock Option Plan (Annexed as Appendix F to the Joint Proxy Statement/Prospectus).
  **                                                                                                                                                                
| |          |                                                                                                                                                                                                                                                                                         
| | 10(e)    | 1997 Incentive and Non-Qualified Stock Option Plan (Annexed as Appendix B to the Proxy Statement on
  Form 14A filed November 5, 1997). **                                                                                                                                              
| |          |                                                                                                                                                                                                                                                                                         
| | 10(f)    | Employment Agreement dated as of April 2, 2001, between Pharmos Corporation and Haim Aviv (Incorporated
  by reference to Exhibit 10(n) to the Companys Annual Report on Form 10-K for the year ended
  December 31, 2001).**                                                          
| |          |                                                                                                                                                                                                                                                                                         
| | 10(g)    | Employment Agreement dated as of April 2, 2001, between Pharmos Corporation and Gad Riesenfeld (Incorporated
  by reference to Exhibit 10(o) to the Companys Annual Report on Form 10-K for the year ended
  December 31, 2001).**                                                     
| |          |                                                                                                                                                                                                                                                                                         
| | 10(h)    | Amendment of Employment Agreement dated as of April 23, 2001, between Pharmos Corporation and Gad Riesenfeld
  (Incorporated by reference to Exhibit 10(p) to the Companys Annual Report on Form 10-K for
the year ended December 31, 2001).**                                         

| |       |                                                                                                                                                                                                                                
| | ----- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| | 10(i) | Employment Agreement dated as of April 2, 2001, between Pharmos Corporation and Robert W. Cook (Incorporated by reference to Exhibit 10(q) to the Companys Annual Report on Form 10-K for the year ended December 31, 2001).**

|50
|--



| | 10(j)    | 2001 Employee Stock Purchase Plan (Incorporated by reference to Exhibit B to the Companys Definitive
  Proxy Statement on Form 14A filed on June 6, 2001).**                                                                                                                      
| | -------- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |          |                                                                                                                                                                                                                                                                                    
| | 10(k)    | Asset Purchase Agreement between Bausch & Lomb Incorporated and Pharmos Corporation dated October
  9, 2001 (Incorporated by reference to Exhibit 2.1 to the Companys Current Report on Form 8-K
  filed on October 16, 2001).                                                    
| |          |                                                                                                                                                                                                                                                                                    
| | 10(l)    | License Assignment and Amendment Agreement dated as of October 9, 2001 by and among Dr. Nicholas S.
  Bodor, Pharmos Corporation and Bausch & Lomb Incorporated (Incorporated by reference to Exhibit
  2.2 to the Companys Current Report on Form 8-K filed on October 16, 2001).
| |          |                                                                                                                                                                                                                                                                                    
| | 10(m)    | Amendment No. 1 to Asset Purchase Agreement dated as of December 28, 2001 between Bausch & Lomb
  Incorporated and Pharmos Corporation (Incorporated by reference to Exhibit 10(v) to the Companys
  Annual Report on Form 10-K for the year ended December 31, 2001).            
| |          |                                                                                                                                                                                                                                                                                    
| | 10(n)    | License Agreement dated as of December 18, 2001 between Pharmos Ltd. and Herbamed Ltd. (Incorporated
  by reference to Exhibit 10(p) to the Annual Report on Form 10-K for year ended December 31, 2002).                                                                          
| |          |                                                                                                                                                                                                                                                                                    
| | 10(o)*** | Amended and Restated 2000 Incentive and Non-Qualified Stock Option Plan.**                                                                                                                                                                                                         
| |          |                                                                                                                                                                                                                                                                                    

| | 10(p)    | Underwriting Agreement dated as of January 5, 2004 between the Company and C.E. Unterberg, Towbin and
  Harris Nesbitt Corp. LLP (Incorporated by reference to Exhibit 1.1 to the Companys Current
  Report on Form 8-K filed on December 19, 2003).    
| | -------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |          |                                                                                                                                                                                                                                                          
| | 10(q)*** | Separation Agreement dated as of April 20, 2004 between Pharmos Corporation and Robert W. Cook**                                                                                                                                                         
| |          |                                                                                                                                                                                                                                                          
| | 10(r)    | Employment Agreement dated as of July 19, 2004 between Pharmos Corporation and James A. Meer (Incorporated
  by reference to Exhibit 10.1 to the Companys Quarterly Report on Form 10-Q for the quarter
  ended September 30, 2004).**                  
| |          |                                                                                                                                                                                                                                                          
| | 10(s)    | Placement Agent Agreement dated as of August 20, 2004 between the Company and Rodman and Renshaw, Inc.
  and Harris Nesbitt Corp. LLP (Incorporated by reference to Exhibit 99.1 to the Companys Current
  Report on Form 8-K filed on August 23, 2004).
| |          |                                                                                                                                                                                                                                                          
| | 10(t)    | Retention Award Agreement dated as of September 6, 2004 between Pharmos Corporation and Dr. Haim Aviv
  (Incorporated by reference to Exhibit 10.1 to the Companys Current Report on Form 8-K filed
  on September 10, 2004).**                         
| |          |                                                                                                                                                                                                                                                          
| | 10(u)    | Retention Award Agreement dated as of September 6, 2004 between Pharmos Corporation and Dr. Gad Riesenfeld
  (Incorporated by reference to Exhibit 10.2 to the Companys Current Report on Form 8-K filed
  on September 10, 2004).**                    
| |          |                                                                                                                                                                                                                                                          
| | 10(v)*** | Amendment No. 2 to Asset Purchase Agreement dated as of December 30, 2004 between Bausch & Lomb
  Incorporated and Pharmos Corporation.                                                                                                                  
| |          |                                                                                                                                                                                                                                                          
| | 10(w)*** | Amendment of Employment Agreement dated as of February 16, 2005 between Pharmos Corporation and Gad
  Riesenfeld.**                                                                                                                                      

|                  
|------------------
|14  Code of Ethics
|                  

| | 14(a)***        Pharmos Corporation Code of Ethics and Business
Conduct
| | -----------------------------------------------------------------------

|                                    
|------------------------------------
|21    Subsidiaries of the Registrant
|                                    

| | 21(a) | Subsidiaries of the Registrant (Incorporated by reference to Annual Report on Form 
  10-K, as amended by Form 10-K/A, for year ended December 31, 1992).
| | ----- | ---------------------------------------------------------------------------------------------------------------------------------------------------------

|                                     
|-------------------------------------
|23    Consents of Experts and Counsel
|                                     

| | 23(a) *** | Consent of PricewaterhouseCoopers LLP
| | --------- | -------------------------------------

|                                           
|-------------------------------------------
|31  Rule 13a-14(a)/15d-14(a) Certifications
|                                           

| | 31(a)***        Certification of Chief Executive Officer
| | --------------------------------------------------------

|51
|--



| | 31(b)***        Certification of Chief Financial Officer
| | --------------------------------------------------------

|                               
|-------------------------------
|32  Section 1350 Certifications
|                               

| | 32(a)***        Section 1350 Certification of Chief Executive
Officer and Chief Financial Officer
| | -------------------------------------------------------------------------------------------------
| |                                                                                                  

|
|-----
|     

|(1) | Confidential information is omitted and identified by a * and filed separately with the SEC.
|--- | --------------------------------------------------------------------------------------------

|                                                                                                                    
|--------------------------------------------------------------------------------------------------------------------
|(**)         This document is a management contract or compensatory
plan or arrangement.
(***)       Filed herewith.

|52
|--



|SIGNATURES
Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the Registrant
has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|                                                                                                                                                                                                                           

| | PHARMOS CORPORATION                            
| | -----------------------------------------------
| |                                                
| | By: /s/ Haim Aviv                              
| |                                                
| | Dr. Haim Aviv, Chairman of the Board and Chief 
| | Executive Officer (Principal Executive Officer)

|                                                                                                                                                                                                                                     
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Date: March 9, 2005
    Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the Registrant and in the capacities and on the dates indicated:
|                                                                                                                                                                                                                                     

|Signature                           |  |                                    | Title |               | Date
|----------------------------------- |  | ---------------------------------- | ----- | ------------- | ----
|                                    |  |                                    |       |               |     
|/s/ James A. Meer                   |  | Chief Financial Officer (Principal |       | March 9, 2005
|                                    |  | Financial and Accounting Officer), |       |              
|James A. Meer                       |  | and Secretary                      |       |              
|                                    |  |                                    |       |              
|/s/ David Schlachet                 |  | Director                           |       | March 9, 2005
|                                    |  |                                    |       |              
|David Schlachet                     |  |                                    |       |              
|                                    |  |                                    |       |              
|/s/ Mony Ben Dor                    |  | Director                           |       | March 9, 2005
|                                    |  |                                    |       |              
|Mony Ben Dor                        |  |                                    |       |              
|                                    |  |                                    |       |              
|/s/ Georges Anthony Marcel          |  | Director                           |       | March 9, 2005
|                                    |  |                                    |       |              
|Georges Anthony Marcel, M.D., Ph.D. |  |                                    |       |              
|                                    |  |                                    |       |              
|/s/ Elkan R. Gamzu                  |  | Director                           |       | March 9, 2005
|                                    |  |                                    |       |              
|Elkan R. Gamzu, Ph.D.               |  |                                    |       |              
|                                    |  |                                    |       |              
|/s/ Lawrence F. Marshall            |  | Director                           |       | March 9, 2005
|                                    |  |                                    |       |              
|Lawrence F. Marshall, M.D.          |  |                                    |       |              

|53
|--



|Pharmos CorporationIndex to Consolidated Financial Statements
|-------------------------------------------------------------

|                                                                                                              
|--------------------------------------------------------------------------------------------------------------
|Report of Independent Registered Public Accounting Firm                                                       
|Consolidated balance sheets as of December 31, 2004 and 2003                                                  
|Consolidated statements of operations for the years endedDecember 31, 2004, 2003 and 2002                     
|Consolidated statements of changes in shareholders equityfor the years ended December 31, 2004, 2003 and 2002
|Consolidated statements of cash flows for the years endedDecember 31, 2004, 2003, and 2002                    
|Notes to consolidated financial statements                                                                    

|F-1
|---



|Report of Independent Registered Public Accounting Firm
To the Board of Directors and Shareholders of Pharmos Corporation:
We have completed an integrated audit of Pharmos Corporations 2004 consolidated financial statements
and of its internal control over financial reporting as of December 31, 2004 and audits of its 2003
and 2002 consolidated financial statements in accordance with the standards of the Public Company
Accounting Oversight Board (United States). Our opinions, based on our audits, are presented below.
Consolidated financial statements
In our opinion, the consolidated financial statements listed in the accompanying index present fairly,
in all material respects, the financial position of Pharmos Corporation and its subsidiary (the Company)
at December 31, 2004 and 2003, and the results of their operations and their cash flows for each
of the three years in the period ended December 31, 2004 in conformity with accounting principles
generally accepted in the United States of America. These financial statements are the responsibility
of the Companys management. Our responsibility is to express an opinion on these financial
statements based on our audits. We conducted our audits of these statements in accordance with the
standards of the Public Company Accounting Oversight Board (United States). Those standards require
that we plan and perform the audit to obtain reasonable assurance about whether the financial statements
are free of material misstatement. An audit of financial statements includes examining, on a test
basis, evidence supporting the amounts and disclosures in the financial statements, assessing the
accounting principles used and significant estimates made by management, and evaluating the overall
financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.
Internal control over financial reporting
Also, in our opinion, managements assessment, included in Managements Annual Report
on Internal Control Over Financial Reporting appearing under Item No. 9A, that the Company
maintained effective internal control over financial reporting as of December 31, 2004 based on criteria
established in Internal Control  Integrated Framework issued by the Committee of Sponsoring
Organization of the Treadway Commission (COSO), is fairly stated, in all material respects, based
on those criteria. Furthermore, in our opinion, the Company maintained, in all material respects,
effective internal control over financial reporting as of December 31, 2004, based on criteria established
in Internal Control  Integrated Framework issued by the COSO. The Companys management is
responsible for maintaining effective internal control over financial reporting and for its assessment
of the effectiveness of internal control over financial reporting. Our responsibility is to express
opinions on managements assessment and on the effectiveness of the Companys internal
control over financial reporting based on our audit. We conducted our audit of internal control over
financial reporting in accordance with the standards of the Public Company Accounting Oversight Board
(United States). Those standards require that we plan and perform the audit to obtain reasonable
assurance about whether effective internal control over financial reporting was maintained in all
material respects. An audit of internal control over financial reporting includes obtaining an understanding
of internal control over financial reporting, evaluating managements assessment, testing and
evaluating the design and operating effectiveness of internal control, and performing such other
procedures as we consider necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinions.
A companys internal control over financial reporting is a process designed to provide reasonable
assurance regarding the reliability of financial reporting and the preparation of financial statements
for external purposes in accordance with generally accepted accounting principles. A companys
internal control over financial reporting includes those policies and procedures that (i) pertain
to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions
and dispositions of the assets of the company; (ii) provide reasonable assurance that transactions
are recorded as necessary to permit preparation of financial statements in accordance with generally
accepted accounting principles, and that receipts and
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|F-2
|---



|expenditures of the company are being made only in accordance with authorizations of management and
directors of the company; and (iii) provide reasonable assurance regarding prevention or timely
detection of unauthorized acquisition, use, or disposition of the companys assets that could
have a material effect on the financial statements.
Because of its inherent limitations, internal control over financial reporting may not prevent or detect

misstatements. Also, projections of any evaluation of effectiveness to future periods are subject

to the risk that controls may become inadequate because of changes in conditions, or that the degree

of compliance with the policies or procedures may deteriorate.
PricewaterhouseCoopers LLPNew York, NYMarch 7, 2005
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|F-3
|---



|**Pharmos Corporation**Consolidated Balance Sheets
|--------------------------------------------------
|                                                  
|                                                  

|                                                                    | December 31, |             
|------------------------------------------------------------------- | ------------ | ------------
|
|
|                                                                    |              |             
|Assets                                                              |              |             
|Current assets                                                     
|Cash and cash equivalents                                           | $            | 49,014,530  
|Restricted cash                                                     |              | 4,846,155   
|Research and development grants receivable                          |              | 1,537,782   
|Debt issuance costs                                                 |              | 45,648      
|Prepaid expenses and other current assets                           |              | 262,810     
|                                                                    |              |             
|Total current assets                                                |              | 55,706,925  
|Fixed assets, net                                                   |              | 987,451     
|Restricted cash                                                     |              | 139,594     
|Severance pay funded                                                |              | 811,926     
|Other assets                                                        |              | 18,946      
|Debt issuance costs                                                 |              |            
|                                                                    |              |             
|Total assets                                                        | $            | 57,664,842  
|                                                                    |              |             
|Liabilities and Shareholders Equity                                |              |             
|Current liabilities                                                 |              |             
|Accounts payable                                                    | $            | 2,462,162   
|Accrued expenses                                                    |              | 1,155,413   
|Warrant liability                                                   |              | 297,955     
|Accrued wages and other compensation                                |              | 756,488     
|Convertible debentures, net                                         |              | 4,765,540   
|                                                                    |              |             
|Total current liabilities                                           |              | 9,437,558   
|Other liability                                                     |              | 39,412      
|Convertible debentures, net                                         |              |            
|Severance pay                                                       |              | 1,197,039   
|                                                                    |              |             
|Total liabilities                                                   |              | 10,674,009  
|                                                                    |              |             
|Commitments and Contingencies (Note 14)                             |              |             
|Shareholders equity                                                |              |             
|Preferred stock, $.03 par value, 1,250,000 shares authorized,       |              |             
|none issued and outstanding                                         |              |            
|Common stock, $.03 par value; 150,000,000 shares authorized,        |              |             
|95,137,076 and 85,568,205 issued, 2004 and 2003, respectively       |              | 2,854,112   
|Deferred compensation                                               |              | (1,701,122  
|Paid in capital                                                     |              | 188,809,955 
|Accumulated deficit                                                 |              | (142,971,686
|Treasury stock at cost 14,189 shares in 2004 and 2003, respectively |              | (426        
|                                                                    |              |             
|Total shareholders equity                                          |              | 46,990,833  
|                                                                    |              |             
|Total liabilities and shareholders equity                          | $            | 57,664,842  
|                                                                    |              |             
|                                                                    |              |             
|                                                                    |              |             

|                                                                                       
|---------------------------------------------------------------------------------------
|The accompanying notes are an integral part of these consolidated financial statements.

|F-4
|---



|Pharmos CorporationConsolidated Statements of Operations
|--------------------------------------------------------
|                                                        
|                                                        

|                                              | Year Ended December 31, |            
|--------------------------------------------- | ----------------------- | -----------
|
|
|                                              |                         |            
|Expenses                                      |                         |            
|Research and development, gross               |                         | 16,335,334 
|Grants                                        |                         | (3,446,677 
|                                              |                         |            
|Research and development, net                 |                         | 12,888,657 
|(exclusive of depreciation and amortization   |                         |            
|shown separately below)                       |                         |            
|General and administrative (exclusive         |                         |            
|of depreciation and amortization              |                         |            
|shown separately below)                       |                         | 6,413,803  
|Depreciation and amortization                 |                         | 577,691    
|                                              |                         |            
|Total operating expenses                      |                         | 19,880,151 
|                                              |                         |            
|Loss from operations                          |                         | (19,880,151
|                                              |                         |            
|Other expense                                 |                         |            
|Interest income                               |                         | 658,010    
|Other (expense) income, net                   |                         | (9,939     
|Derivative gain (loss)                        |                         | 525,074    
|Interest expense                              |                         | (3,705,535 
|                                              |                         |            
|Other expense, net                            |                         | (2,532,390 
|                                              |                         |            
|Loss before income taxes                      |                         | (22,412,541
|Income tax benefit                            |                         | (444,774   
|                                              |                         |            
|Net loss                                      | $                       | (21,967,767
|                                              |                         |            
|Net loss per share - basic                    | $                       | (.24       
|                                              |                         |            
|Net loss per share - diluted                  | $                       | (.24       
|                                              |                         |            
|                                              |                         |            
|Weighted average shares outstanding - basic   |                         | 90,166,789 
|                                              |                         |            
|Weighted average shares outstanding - diluted |                         | 90,166,789 
|                                              |                         |            
|                                              |                         |            
|                                              |                         |            

|                                                                                       
|---------------------------------------------------------------------------------------
|The accompanying notes are an integral part of these consolidated financial statements.

|F-5
|---



|Pharmos CorporationConsolidated Statements of Changes in Shareholders Equity (Notes 8 & 9)For the Years ended December 31, 2004, 2003 and 2002
|-----------------------------------------------------------------------------------------------------------------------------------------------
|                                                                                                                                               
|                                                                                                                                               

|                                                                                  | Common Stock |   |        |           |                       |   |                                            |   | Treasury Stock      |            
|--------------------------------------------------------------------------------- | ------------ | - | ------ | --------- | --------------------- | - | ------------------------------------------ | - | ------------------- | -----------
|                                                                                  | Shares       |   | Amount |           | Deferred Compensation |   | Paid-in
      Capital in
    Excess of Par |   | Accumulated Deficit |            
|                                                                                  |              |   |        |           |                       |   |                                            |   |                     |            
|December 31, 2001                                                                 | 55,374,663   |   | $      | 1,661,239 |                       | $ | (223,144                                   | ) | $                   | 111,151,758
|Option issuance for consultant compensation                                       |              |   |        |           |                       |   | 50,175                                     |   |                     | 13,362     
|Issuance of and amortization of stock
options issuances below fair market value   |              |   |        |           |                       |   | 52,981                                     |   |                     |            
|Accretion of fair value of refinanced debt                                        |              |   |        |           |                       |   |                                            |   |                     | 420,221    
|Stock adjustment                                                                  | (40,583      | ) |        | (1,217    | )                     |   |                                            |   |                     | 1,092      
|Issuance of Common Stock  Employee
Stock Purchase Plan                           | 23,284       |   |        | 699       |                       |   |                                            |   |                     | 20,057     
|Conversion of convertible debt and
interest to equity                             | 1,217,485    |   |        | 36,525    |                       |   |                                            |   |                     | 2,581,068  
|Net Loss                                                                          |              |   |        |           |                       |   |                                            |   |                     |            
|                                                                                  |              |  
|December 31, 2002                                                                 | 56,574,849   |   |        | 1,697,246 |                       |   | (119,988                                   | ) |                     | 114,187,558
|                                                                                  |              |   |        |           |                       |   |                                            |   |                     |            
|Warrant and option exercises                                                      | 3,992,845    |   |        | 119,785   |                       |   |                                            |   |                     | 6,178,229  
|Warrant derivative adjustments                                                    |              |   |        |           |                       |   |                                            |   |                     | 936,156    
|Option issuance for consultant  compensation                                      |              |   |        |           |                       |   |                                            |   |                     | 56,866     
|Issuance of and amortization of stock
option issuance below fair market value     |              |   |        |           |                       |   | 53,328                                     |   |                     |            
|Accretion of fair value of refinanced debt                                        |              |   |        |           |                       |   |                                            |   |                     | 68,808     
|Reversal of benefit conversion feature                                            |              |   |        |           |                       |   |                                            |   |                     | (786,000   
|Issuance of Common Stock  Employee
Stock Purchase Plan                           | 29,919       |   |        | 898       |                       |   |                                            |   |                     | 38,993     
|Issuance of Common Stock  public
offering sales, net of fees of $2 million       | 10,500,000   |   |        | 315,000   |                       |   |                                            |   |                     | 26,548,131 
|Issuance of warrants with Convertible
Debenture offering, net of fees of $277,000 |              |   |        |           |                       |   |                                            |   |                     | 3,663,949  
|Issuance of Common Stock  private
equity sales, net of fees of $892,000          | 14,470,592   |   |        | 434,118   |                       |   |                                            |   |                     | 11,067,369 
|Net Loss                                                                          |              |   |        |           |                       |   |                                            |   |                     |            
|                                                                                  |              |  
|December 31, 2003                                                                 | 85,568,205   |   |        | 2,567,047 |                       |   | (66,660                                    | ) |                     | 161,960,059
|                                                                                  |              |   |        |           |                       |   |                                            |   |                     |            
|Warrant and option exercises                                                      | 1,200,217    |   |        | 36,006    |                       |   |                                            |   |                     | 2,030,703  
|Option issuance for consultant compensation                                       |              |   |        |           |                       |   |                                            |   |                     | 578,238    
|Issuance of and amortization of stock
option issuance below fair market value     |              |   |        |           |                       |   | (2,112                                     | ) |                     | 74,000     
|Issuance of Common Stock  Employee
Stock Purchase Plan                           | 9,493        |   |        | 285       |                       |   |                                            |   |                     | 28,714     
|Issuance of Common Stock  public
offering sales, net of fees of $286,000         | 1,575,000    |   |        | 47,250    |                       |   |                                            |   |                     | 3,997,623  
|Conversion of convertible debt and
interest and exercise of warrants              | 947,662      |   |        | 28,429    |                       |   |                                            |   |                     | 2,632,213  
|Issuance of Common Stock  private
equity sales, net of fees of $1.110,000        | 5,583,334    |   |        | 167,500   |                       |   |                                            |   |                     | 15,515,998 
|Issuance of Retention Award Agreements                                            | 253,165      |   |        | 7,595     |                       |   | (1,632,350                                 | ) |                     | 1,992,407  
|Net Loss                                                                          |              |   |        |           |                       |   |                                            |   |                     |            
|                                                                                  |              |  
|                                                                                  |              |   |        |           |                       |   |                                            |   |                     |            
|December 31, 2004                                                                 | 95,137,076   |   | $      | 2,854,112 |                       |   | ($1,701,122                                | ) | $                   | 188,809,955
|                                                                                  |              |   |        |           |                       |   |                                            |   |                     |            

|                                                                                       
|---------------------------------------------------------------------------------------
|The accompanying notes are an integral part of these consolidated financial statements.

|F-6
|---



|Pharmos CorporationConsolidated Statements of Cash Flows
|--------------------------------------------------------
|                                                        
|                                                        

|                                                          | Year Ended December 31, |            
|--------------------------------------------------------- | ----------------------- | -----------
|
|                                                          |                         |            
|Cash flows from operating activities:                     |                         |            
|Net loss                                                  | $                       | (21,967,767
|Adjustments to reconcile net loss to net                  |                         |            
|cash flow used in operating activities:                   |                         |            
|Depreciation                                              |                         | 577,691    
|Interest expense convertible debentures converted         |                         |            
|into common stock                                         |                         | 10,555     
|Reversal of beneficial conversion feature                 |                         |           
|Provision for severance pay                               |                         | 208,034    
|Change in the value of warrants                           |                         | (525,074   
|Amortization of debt discount and issuance costs          |                         | 3,126,954  
|Amortization of fair value of change in convertible debt  |                         |           
|Option issuances - consultant compensation                |                         | 578,238    
|Amortization of stock options issued below                |                         |            
|fair market value                                         |                         | 71,888     
|Amortization of restricted share issuance                 |                         | 367,652    
|Changes in operating assets and liabilities:              |                         |            
|Research and development grant receivable                 |                         | (856,537   
|Prepaid expenses and other current assets                 |                         | 322,210    
|Severance pay funding                                     |                         | (197,515   
|Other assets                                              |                         | 1,643      
|Accounts payable                                          |                         | (543,299   
|Accrued expenses                                          |                         | (595,787   
|Accrued wages & other compensation                        |                         | (355,447   
|Other liabilities                                         |                         | 29,412     
|                                                          |                         |            
|Net cash used in operating activities                     |                         | (19,747,149
|                                                          |                         |            
|Cash flows from investing activities:                     |                         |            
|Purchases of fixed assets                                 |                         | (310,046   
|                                                          |                         |            
|                                                          |                         |            
|Decrease (increase) in restricted cash                    |                         | 11,190,858 
|                                                          |                         |            
|Net cash provided by (used in)                            |                         |            
|investing activities                                      |                         | 10,880,812 
|                                                          |                         |            
|Cash flows from financing activities:                     |                         |            
|Proceeds from issuance of common stock                    |                         |            
|and exercise of options and warrants, net                 |                         | 22,742,078 
|Proceeds from issuance of convertible debentures          |                         |            
|and warrants, net                                         |                         |           
|Repayment of convertible debentures, net                  |                         | (14,153,852
|Fees related to refinancing convertible debt              |                         |           
|                                                          |                         |            
|Net cash provided by (used in)                            |                         |            
|financing activities                                      |                         | 8,588,226  
|                                                          |                         |            
|Net (decrease) increase in cash and cash equivalents      |                         | (278,111   
|Cash and cash equivalents at beginning of year            |                         | 49,292,641 
|                                                          |                         |            
|Cash and cash equivalents at end of year                  | $                       | 49,014,530 
|                                                          |                         |            
|Supplemental Information:                                 |                         |            
|Interest paid                                             | $                       | 560,554    
|                                                          |                         |            
|Supplemental disclosure of non-cash financing activities: |                         |            
|Conversion of convertible debt and interest to equity     | $                       | 2,000,000  
|Non-cash fees for equity financings                       |                         |           
|                                                          |                         |            

|                                                                                       
|---------------------------------------------------------------------------------------
|The accompanying notes are an integral part of these consolidated financial statements.

|F-7
|---



|Pharmos CorporationNotes to Consolidated Financial Statements
1.     The Company
|--------------------------------------------------------------------------------
|                                                                                

| | Pharmos Corporation (the Company or Pharmos) is a bio-pharmaceutical company
  that discovers and develops new drugs to treat a range of neuro-inflammatory disorders. The Company
  has executive offices in Iselin, New Jersey and conducts research and development and pilot manufacturing
  through its wholly owned subsidiary, Pharmos, Ltd., in Rehovot, Israel.
| | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|                                  
|----------------------------------
|2.    Liquidity and Business Risks
|                                  

| | Except for 2001, the Company has experienced operating losses every year since inception in funding
  the research, development and clinical testing of our drug candidates. As of December 31, 2004, the
  Companys accumulated deficit was approximately $143.0 million. The Company expects to incur
  additional losses over the next several years as the Companys research and development and
  clinical trial programs continue. The Company has funded its operations through the use of cash obtained
  principally from third party financing. Management believes that the current cash and cash equivalents
  of $49.0million as of December 31, 2004, will be sufficient to support the Companys continuing
  operations beyond December 31, 2005.
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | The Company is continuing to actively pursue various funding options, including additional equity offerings,
  strategic corporate alliances, business combinations and the establishment of product related research
  and development limited partnerships to obtain additional financing to continue the development of
  its products and bring them to commercial markets. Should the Company be unable to raise adequate
  financing in the future, long-term projects will need to be scaled back or discontinued (See Note
  18 for subsequent events).                                                                                                                                                                                                    

|                                     
|-------------------------------------
|3.    Significant Accounting Policies
|                                     

| | Basis of consolidation                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| | The accompanying consolidated financial statements include the accounts of the Company and its wholly
  owned subsidiary, Pharmos Ltd. All significant intercompany balances and transactions are eliminated
  in consolidation.                                                                                                                                                                                                                                                                                                                                                                                                                       
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| | Use of estimates                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| | The preparation of the consolidated financial statements in conformity with generally accepted accounting
  principles requires the Company to make estimates and assumptions that affect the reported amounts
  of assets and liabilities, disclosure of contingent assets and liabilities at the date of the financial
  statements and the reported amounts of revenues, costs and expenses during the reporting period.
  The most significant estimates and assumptions related to asset impairments, including estimates
  of commitments and contingencies, and the tax valuation allowance. Actual results could differ from
  those estimates.
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| | Net loss per common share                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| | Basic and diluted net loss per common share was computed by dividing the net loss for the period by
  the weighted average number of shares of common stock issued and outstanding. In accordance with
  the requirements of Statement of Financial Accounting Standards No. 128, common stock equivalents
  have been excluded from the calculation of diluted net loss per common share, as their inclusion
  would be antidilutive.                                                                                                                                                                                                                 

|F-8
|---



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | The following table summarized the equivalent number of common shares assuming the related securities
  that were outstanding as of December 31, 2004 and 2003 had been converted.
| | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                   

|                                                    | 2004 |  | 2003       |  | 2002 |           
|--------------------------------------------------- | ---- |  | ---------- |  | ---- | ----------
|                                                    |      |  |            |  |      |           
|Stock options                                       |      |  | 3,959,967  |  |      | 3,791,449 
|Warrants                                            |      |  | 6,915,940  |  |      | 7,722,997 
|Shares issuable upon exercise of convertible debt   |      |  | 1,207,540  |  |      | 5,344,768 
|Restricted stock  non vested                       |      |  | 632,912    |  |      |          
|                                                    |      |  |            |  |      |           
|Total potential dilutive securities not included in |      |  |            |  |      |           
|loss per share in loss per share                    |      |  | 12,716,359 |  |      | 16,859,214
|                                                    |      |  |            |  |      |           
|                                                    |      |  |           

| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| | Cash and cash equivalents                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | The Company considers all highly liquid instruments purchased with an original maturity of three months
  or less to be cash equivalents. Cash equivalents primarily consist of commercial paper and money
  market accounts in 2004 and 2003.                                                                                                                                                                                                                                                                                                                                                                                                           
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | Revenue recognition                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | The Companys policy with respect to license fees is to recognize revenue when all performance
  obligations are completed. The Company had no product sales revenue during 2004, 2003, or 2002 and
  does not expect product sale revenues for the next few years and may never have such sales if products
  currently under development fail to be commercialized.                                                                                                                                                                                                                                                                                    
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | Research and development costs                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | All research and development costs are expensed when incurred. The Company accounts for reimbursements
  of research and development costs as a reduction of research and development expenses as the underlying
  expenses are incurred.                                                                                                                                                                                                                                                                                                                                                                                                                
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | Research and development grants receivable                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | As of December 31, 2004 and 2003, research and development grant receivables consist of grants for
  research and development relating to certain projects. Research and development grants are recognized
  as a reduction of research and development expenses.                                                                                                                                                                                                                                                                                                                                                                                        
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | Restricted cash                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | In connection with the September 2003 Convertible Debenture offering, the terms of the agreement required
  the Company to establish an escrow account. The escrowed account is shown as Restricted Cash on the
  Companys balance sheet and will be released to the Company in proportion to the amount of Convertible
  Debentures converted into common shares or upon the repayment of the debt beginning March 2004. The
  terms of the debentures further stipulates that the restricted cash can only be used to fund acquisitions
  upon the approval of the investors. The short-term balance represents debt repayment due within 12
  months.
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | The Company has a lease agreement for the premises it occupies in New Jersey. The lease agreement expires
  in 2009. The lease agreement is secured by a letter of credit of $62,142. This amount is included
  restricted cash at December 31, 2004.                                                                                                                                                                                                                                                                                                                                                                                                    
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | In addition, the Companys subsidiary, Pharmos Ltd., has a lease agreement for the premises it
  occupies in Israel. The lease agreement expires in November 2006. The lease agreement is secured
  by a                                                                                                                                                                                                                                                                                                                                                                                                                                                 

|F-9
|---



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | letter of guarantee in the amount of $169,556 based on the Israeli consumer price index. A deposit of $77,452 is included in restricted cash at December 31, 2004.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | Fixed assets                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | Fixed assets are recorded at cost and are depreciated on a straight-line basis over their estimated
  useful lives. The Company uses the following estimated useful lives:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | Laboratory, pilot plant and other equipment                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
| | Leasehold improvements                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
| | Office furniture and fixtures                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
| | Computer equipment                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | Vehicles                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | Leasehold improvements are amortized on a straight-line basis over the shorter of the lease term or the estimated lives of the related assets. Maintenance and repairs are expensed as incurred.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | Long-lived assets                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | The Company periodically evaluates potential impairments of its long-lived assets. When the Company
  determines that the carrying value of long-lived assets may not be recoverable based upon the existence
  of one or more indicators of impairment, the Company evaluates the projected undiscounted cash flows
  related to the assets and other factors. If these cash flows are less than the carrying value of
  the assets, the Company measures the impairment using discounted cash flows or other methods of determining
  fair value.                                                                                                                                                                                   
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | Severance pay                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | The Companys liability for severance pay is calculated pursuant to Israels Severance Pay Law on the most recent salary of the employees multiplied by the number of years of employment, as
  of the balance sheet date. Employees are entitled to one months salary for each year of employment
  or a portion thereof. The Companys liability for all of its Israeli employees is fully provided
  by monthly deposits with insurance policies and by an accrual. The value of these policies is recorded
  as an asset in the Companys balance sheet.                                                                                                                                                                         
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | The deposited funds may be withdrawn only upon the fulfillment of the obligation pursuant to Israels
  Severance Pay Law or labor agreements. The value of the deposited funds is based on the cash surrender
  value of these policies, and includes immaterial profits accumulated up to the balance sheet date.                                                                                                                                                                                                                                                                                                                                                                                                                   
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | Severance expenses for the years ended December 31, 2004, 2003 and 2002 amounted to approximately $212,339,
  $161,968 and $103,804, respectively.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | Income taxes                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | The Company accounts for income taxes in accordance with the provisions of Statement of Financial Accounting
  Standards No. 109, Accounting for Income Taxes (SFAS 109). Under the asset
  and liability method of SFAS 109, deferred tax assets and liabilities are recognized for the future
  tax consequences attributable to differences between the financial statement carrying amounts of
  existing assets and liabilities and their respective tax bases and operating loss and tax credit
  carryforwards. Deferred tax assets and liabilities, if any, are measured using enacted tax rates
  expected to apply to taxable income in the years in which those temporary differences are expected
  to be recovered or

|F-10
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | settled.  Under SFAS 109, the effect on deferred tax assets and liabilities of a change in tax
  rates is recognized in income in the period that includes the enactment date.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
| | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | Foreign exchange                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | The Companys foreign operations are principally conducted in U.S. dollars. Any transactions or
  balances in currencies other than U.S. dollars are remeasured and any resultant gains and losses
  are included in other (expense) income. To date, such gains and losses have been insignificant.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | Concentration of credit risk                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | Financial instruments that potentially expose the Company to concentrations of credit risk consist
  primarily of cash and cash equivalents. The Company maintains some of its cash balances in accounts
  that exceed federally insured limits. The Company has not experienced any losses to date resulting
  from this practice.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | Fair value of financial instruments                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | The carrying amounts of the Companys financial instruments, including cash and cash equivalents,
  other receivables, other assets, accounts payable, accrued liabilities, and convertible debentures
  approximate fair value due to their short term maturities.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | Equity based compensation                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | The Company accounts for its employee stock option plans in accordance with the provisions of Accounting
  Principles Board Opinion No. 25, Accounting for Stock Issued to Employees, and related
  interpretations. As such, compensation expense related to employee stock options is recorded only
  if, on the date of grant, the fair value of the underlying stock exceeds the exercise price. The
  Company adopted the disclosure-only requirements of SFAS No. 123, Accounting for Stock-Based
  Compensation, which allows entities to continue to apply the provisions of APB Opinion No.
  25 for transactions with employees and provide pro forma operating results and pro forma per share
  disclosures for employee stock grants as if the fair-value-based method of accounting in SFAS No.
  123 had been applied to these transactions. Options issued to non-employees are valued using the
  fair value methodology under SFAS No. 123.

|F-11
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | The following table illustrates the effect on net (loss) income and earnings per share if the Company
  had applied the fair value recognition provisions of SFAS No. 123 to stock-based employee compensation.
  The estimated fair value of each option is calculated using the Black-Scholes option-pricing model.
| | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                      

|                                       | Year Ended December 31, |               
|-------------------------------------- | ----------------------- | --------------
|
|                                       |                         |               
|Net loss as reported                   |                         | ($ 21,967,767)
|Add: Stock-based employee compensation |                         |               
|expense included in reported net loss  |                         | 439,540       
|Deduct:Total stock-based employee      |                         |               
|compensation expense determined under  |                         |               
|fair value based method for all awards |                         | (1,705,559)   
|                                       |                         |               
|Pro forma net loss                     |                         | ($ 23,233,786)
|                                       |                         |               
|Earnings per share:                    |                         |               
|Basic  as reported                    |                         | ($ 0.24)      
|Basic  pro forma                      |                         | ($ 0.26)      
|Diluted  as reported                  |                         | ($ 0.24)      
|Diluted  pro forma                    |                         | ($ 0.26)      

| |                                                                                                                                                                                                                      
| | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| | For disclosure purposes under SFAS No. 123, the fair value of each option grant was estimated on the
  date of grant using the Black-Scholes option valuation model with the following weighted-average
  assumption:
| |                                                                                                                                                                                                                      

|                          | 2004 | 2003 |              | 2002 | 
|------------------------- | ---- | ---- | ------------ | ---- | 
|
|Risk-free interest rate   |      |      | 2.89 - 3.69% |      | 
|Expected lives (in years) |      |      | 5            |      | 
|Dividend yield            |      |      | 0 %          |      | 
|Expected volatility       |      |      | 88 - 89 %    |      | 

| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| | Reclassifications                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | Certain amounts for 2003 and 2002 have been reclassified to conform to the fiscal 2004 presentation.
  Such reclassifications did not have an impact on the Companys financial position or results
  of operations. During 2004, the Company reclassified on its balance sheet the presentation of the
  severance pay for Pharmos Ltd.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | Recent Accounting Pronouncements                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | In December 2004, the Financial Accounting Standards Board (FASB) issued Statement of Financial
  Accounting Standards (SFAS) No. 153, Exchanges of Nonmonetary Assets(SFAS 153). SFAS 153 amends Accounting Policy Board (APB) Opinion No.
  29 (APB 29), Accounting for Nonmonetary Transactions, which requires that exchanges of nonmonetary assets be measured based on the fair value of the assets
  exchanged, but which includes certain exceptions to that principle. SFAS 153 eliminates the
  exception from APB 29 for nonmonetary exchanges of similar productive assets and replaces it
  with a general exception for exchanges of nonmonetary assets that do not have a commercial substance.
  SFAS 153 is effective for nonmonetary asset exchanges occurring in fiscal periods beginning
  after June 15, 2005. The adoption of SFAS 153 is not expected to have a material impact
  on our consolidated financial position or results of operations.
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | In December 2004, the FASB issued a revision to SFAS No. 123, Accounting for Stock-Based Compensation
  (SFAS 123R). SFAS 123R replaces SFAS 123 and supersedes APB Opinion No. 25, Accounting
  for Stock Issued to Employees, and establishes standards for the accounting for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 

|F-12
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | transactions in which an entity exchanges its equity instruments for goods or services. SFAS 123R focuses
  primarily on accounting for transactions in which an entity obtains employee services in share-based
  payment transactions and is effective as of the beginning of the first reporting period that begins
  after June 15, 2005 for public entities that do not file as small business issuers. The fair value
  based method of SFAS 123 is similar in most respects to the fair value based method under SFAS 123R,
  although the election of certain methods within the applicable transition rules of SFAS 123R may
  affect the impact on our consolidated financial positions or results of operations. For an approximate
  impact on the 2004 results, please refer to the equity based compensation section discussed above.                                  
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
| | In December 2004, the EITF issued EITF Issue No. 04-08, The Effect of Contingently Convertible
  Debt on Diluted Earnings per Share (EITF 04-08). EITF 04-08 reflects the Task Forces
  conclusion that contingently convertible debt should be included in diluted earnings per share computations
  regardless of whether the market price trigger has been met. The adoption of this statement did not
impact the Companys financial statement presentation.                                                                                                                                                                                                                                                                                                                                                                                                                
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
| | In March 2004, the Emerging Issues Task Force issued EITF 03-6, Participating Securities and
  the Two-Class Method under FASB Statement No. 128. This statement provides additional guidance
  on the calculation and disclosure requirements for earnings per share. The FASB concluded in EITF
  03-6 that companies with multiple classes of common stock or participating securities, as defined
  by SFAS No. 128, calculate and disclose earnings per share based on the two-class method. The adoption
  of this statement does not have an impact to the Companys financial statement presentation.                                                                                                                                                                                                                                                                      
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
| | In December 2004, the Financial Accounting Standards Board issued a FASB Staff Position
  (FSP) that provides accounting guidance on how companies should account for the
  effects of the American Jobs Creation Act of 2004 that was signed into law on October 22, 2004.
  FSP FAS 109-1, Application of FASB Statement No. 109, Accounting for Income Taxes,
  to the Tax Deduction on Qualified Production Activities Provided by the American Jobs Creation Act
  of 2004, states that the manufacturers deduction provided for under this legislation
  should be accounted for as a special deduction instead of a tax rate change. The FSP may affect how
  a company accounts for deferred income taxes. The FSP is effective December 31, 2004. The Company believes that the
adoption of this statement will not have a material impact on its financial position.

|                                            
|--------------------------------------------
|4.     Bausch & Lomb Collaborative Agreement
|                                            

| | Pharmos sold to Bausch & Lomb all of its rights in the U.S. and Europe to manufacture and market
  Lotemax® and Alrex® and Zylet, the third loteprednol etabonate-based product, which was
  submitted to the FDA for marketing approval in September 2003. In December 2004, Bausch & Lomb
  received approval from the FDA of its New Drug Application for Zylet as an ophthalmic anti-inflammatory/antibiotic
  combination product.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
| | During January 2005, an amended agreement was signed in regard to Zylet and the Company received gross
  proceeds of approximately $12.2 million from Bausch & Lomb. Additionally, the Company may receive
  a milestone payment of up to $10 million if actual sales during the first two years following Bausch
& Lombs commercialization exceed agreed-upon forecasted amounts. Pharmos agreed to pay
  up to $3.75 million of Bausch & Lombs costs of developing Zylet, of which $600,000 was
  deducted from the purchase price paid by Bausch & Lomb in October 2001. In July 2003, another
  $1.57 million was paid to Bausch & Lomb. As of December 31, 2004 and 2003, Pharmos owed an additional
  $1.56 million as its share of these research and development related Zylet expenses, which is included
  in accounts payable and represents the final amount Pharmos owes Bausch & Lomb for their project
  development under the terms of the agreement. This amount was paid to Bausch & Lomb in January 2005.
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
| | Pharmos paid Dr. Nicholas Bodor, the loteprednol etabonate patent owner and licensor, who is also a
  former director of and consultant to Pharmos, a total of approximately $2.7 million from the initial                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    

|F-13
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | proceeds of the sale of Lotemax® and Alrex® in return for his consent to Pharmos assignment
  of its rights under the license agreement to Bausch & Lomb ($1.5 million paid at closing and
  $1.2 million paid in October 2002). During January 2005, the Company paid Dr. Bodor approximately
  $1.3 million per the agreement with respect to Zylet. Pharmos owes Dr. Bodor an additional 14.3%
  of any payments the Company may receive from Bausch & Lomb in the event that certain sales
  levels are exceeded in the first two years following commencement of sales in the U.S.
| | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|                  
|------------------
|5.    Fixed Assets
|                  

| | Fixed assets consist of the following:
| | --------------------------------------
| |                                       

|                                            | December 31, |           
|------------------------------------------- | ------------ | ----------
|
|
|                                            |              |           
|Laboratory, pilot plant and other equipment | $            | 2,924,478 
|Leasehold improvements                      |              | 806,454   
|Office furniture and fixtures               |              | 342,129   
|Computer equipment                          |              | 1,231,666 
|Vehicles                                    |              | 86,567    
|                                            |              |           
|                                            |              | 5,391,294 
|Less - Accumulated depreciation             |              | (4,403,843
|                                            |              |           
|Total Fixed Assets                          | $            | 987,451   
|                                            |              |           

|                       |                                                                                                       
|---------------------- | ------------------------------------------------------------------------------------------------------
|                       | Depreciation of fixed assets was $577,691, $654,617 and $691,824 in 2004, 2003 and 2002, respectively.
|                       |                                                                                                       
|6.    Accrued expenses
|                      
|                       | Accrued expenses consist of the following:                                                            
|                      

|                                                    | December 31, |          
|--------------------------------------------------- | ------------ | ---------
|
|
|                                                    |              |          
|Accrued expenses, other                             | $            | 661,045  
|Research & development cost relating to TBI project |              | 494,368  
|                                                    |              |          
|Total accrued expenses                              | $            | 1,155,413
|                                                    |              |          

|                                          
|------------------------------------------
|7.     Grants for Research and Development
|                                          

| | During 2004, 2003 and 2002, gross research and development costs amounted to $16,335,334, $14,928,778
  and $15,093,722, respectively.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
| | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
| | The Company has entered into agreements with the State of Israel, which provide for grants for research
  and development relating to certain projects. Amounts received pursuant to these agreements have
  been reflected as a reduction of research and development expense. Such reductions amounted to $3,446,677,
  $3,295,819 and $2,755,884 during 2004, 2003 and 2002, respectively. The agreements with agencies
  of the State of Israel place certain legal restrictions on the transfer of the technology and manufacture
  of resulting products outside Israel. The Company will be required to pay royalties, at rates ranging
  from 3% to 5%, to such agencies from the sale of products, if any, developed as a result of the research
  activities carried out with the grant funds up to the amount received and interest.
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
| | As of December 31, 2004, the total amounts received under such grants amounted to $13,408,461. Aggregate
  future royalty payments related to sales of products developed, if any, as a result of these grants
  are limited to $11,706,686, exclusive of interest, based on grants received through December 31,
  2004.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      

|F-14
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | The Company signed an agreement with Consortium Magnet for developing generic technologies for design
  and development of drugs and diagnostic kits which consortium is operated by the Office of the Chief
  Scientist of Israel. Under such agreements the Company is entitled to a non-refundable grant amounting
  to approximately 60% of actual research and development and equipment expenditures on approved projects.
  No royalty obligations are required within the framework. As of December 31, 2004, the Company received
  cumulative grants totaling $1,659,549 for this program which was completed and closed.
| | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| | The Company signed an agreement with Consortium Magnet to develop a supply of water-soluble prodrugs
  of lipophilic compounds that improve their bioavailability and biopharmaceutical properties. Under
  such agreement the Company is entitled to a non-refundable grant amounting to approximately 60% of
  actual research and development and equipment expenditures on approved projects. No royalty obligations
  are required within the framework. As of December 31, 2004, the Company received cumulative grants
  totaling $124,527 for this program.                                                                

|                                            
|--------------------------------------------
|8.     Private Placement of Convertible Debt
|                                            

| | On September 26, 2003, the Company completed a private placement of convertible debentures and warrants
  to six institutional investors, generating total gross proceeds of $21.0 million. Five million dollars
  of the proceeds was to be used for working capital purposes, and $16.0 million will be available
  to fund acquisitions upon the approval of the investors. The convertible debentures are convertible
  into common stock of the Company at a fixed price of $4.04, 205% above the closing bid price of the
  stock for the five days preceding the closing date. The debentures, which bear an interest rate of
  4%, will be redeemed in 13 substantially equal monthly increments beginning March 31, 2004. In general,
  amounts converted into shares of Pharmos common stock will reduce the monthly redemption amount proportionately.
  The $16.0 million earmarked for acquisition activity will be held in escrow until used or repaid.
  As of February 28, 2005, the remaining balance of the escrow account associated with the principal
  payment is $1,615,385. In connection with the financing, the Company also issued 5,514,705 three-year
  warrants (including 514,705 placement agent warrants) to purchase 5,514,705 shares of common stock
  at an exercise price of $2.04 per share. Total issuance costs related to the financing were approximately
  $1,229,000 in cash and $434,000 for the value of the placement agent warrants. The issuance costs
  allocated to the warrants were recorded as a reduction to additional paid in capital. The placement
  agent warrants were capitalized and are being amortized over the life of the debt. The Company calculated
  the value of the warrants at the date of the transaction, including the placement agent warrants,
  being approximately $4,652,877 under the Black-Scholes option-pricing method (assumption: volatility
  75%, risk free rate 1.59% and zero dividend yield). The Company allocated the $19.34 million in net
  proceeds between the convertible debentures and the warrants based on their fair values. The Company
  is reporting the debt discount of approximately $3.5 million as a direct reduction to the face amount
  of the debt in accordance with APB 21. The discount will accrete over the life of the outstanding
  debentures. Total accretion of the debt discount from inception through December 31, 2004 was $3,203,433.
  The issuance costs allocated to the convertible debentures of approximately $1.4 million are being
  deferred and amortized to interest expense over the life of the debt. During the first quarter of
  2004, one of the investors converted a total of $2 million plus interest into 497,662 shares of common
  stock. In conjunction with this conversion, the relating unamortized debt discount and issuance costs
  totaling $267,912 was reclassified to additional paid in capital. As of December 31, 2004, approximately
  $16.2 million has been either repaid or converted into common stock of the Company. As of December
  31, 2004, 1,757,000 of the total warrants issued were exercised totaling approximately $3,584,280.
  During 2004, 450,000 warrants were exercised totaling $918,000.
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|F-15
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | As of December 31, 2004, the Convertible Debenture repayment schedule was as follows:
| | -------------------------------------------------------------------------------------
| |                                                                                      

|           | 2005 |          
|---------- | ---- | ---------
|
|Principal  | $    | 4,846,154
|Applicable
|Discount:  |      | (80,614  
|           |      |          
|Total, net | $    | 4,765,540
|           |      |          

| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| | The financing also addressed a possible concern Nasdaq raised informally relating to a violation of
  one of Nasdaqs corporate governance rules. Specifically, Nasdaq expressed a concern that the
  May 2003 private placement, when aggregated with Pharmos March 2003 registered private placement,
  would have resulted in the possible issuance of more than 20% of Pharmos outstanding securities
  at a price less than the applicable fair market value for such shares. Completion of the $21.0 million
  convertible debt financing had the effect of resolving any such Nasdaq concerns.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
| | If after the effective date, November 4, 2003, the closing price of the Companys common stock
  for ten out of any twenty consecutive trading days exceeds $5.50, subject to adjustment for
  reverse and forward stock splits, stock dividends, stock combinations and other similar transactions
  of the Common Stock that occur after the original issue date, the Company may on one occasion, within
  three trading days of any such period, deliver notice to the holder to cause
  the holder to immediately convert all or part of up to 50% of the original aggregate principal amount
  of the debenture. If the Company elects to exercise its right to a $5.50 forced conversion, it
  shall exercise such right ratably among all holders of debentures. In addition, if after the
  effective date, November 4, 2003, the closing price of the Companys common stock
  for ten out of any twenty consecutive trading days exceeds $6.50, the Company may deliver notice
  to the holder to immediately convert all or part of up to the remaining 50% of the original aggregate principal amount of
  the debentures.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
| | In September 2000, the Company completed a private placement of Convertible Debentures, common stock
  and warrants to purchase shares of common stock with institutional investors, generating gross proceeds
  of $11 million. The September 2000 Convertible Debentures, which generated gross proceeds of $8 million,
  were due in February 2002 and carried a 6% interest payable semiannually in cash or common stock.
  The holders of the September 2000 Convertible Debentures and the Company agreed to modify the repayment
  and conversion terms in December 2001. The holders of $5.8 million convertible debt (book value
  on December 31, 2001, including accrued interest) extended the maturity
  date to June 30, 2003 in exchange for a reduction in the conversion price from $3.83 to $2.63 for
  half of the outstanding balance and $ 2.15 for the other half of the outstanding
  balance. The convertible debt with a maturity date of June 2003 was convertible beginning December 31,
  2001. The holder of the remaining outstanding debt of $1.9 million (including accrued interest) changed
  the maturity date from February 28, 2002 to January 31, 2002 in exchange for lowering
  the conversion price for the other holders. As the modification was not significant in accordance
  with EITF 96-19 the change in the fair value between the original convertible debt and the modified
  convertible debt was accreted over the remaining term of the convertible debt with a corresponding
  charge interest expense. During the first quarter of 2002, the Company issued 1,217,485 shares of
  its common stock upon the conversion of $2.5 million principal of the September 2000 Convertible Debenture offering
  and repaid $2 million of the September 2000 Convertible Debentures. During the first quarter
  of 2003, the remaining balance of the $3.5 million was redeemed for approximately $4.0 million, which included accrued interest.
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
| | Emerging Issues Task Force Issue No. 98-5, Accounting for Convertible Securities with Beneficial Conversion Features or Contingently Adjustable Conversion Ratios, required the Company to compute the Beneficial Conversion Feature (BCF) of the convertible debt from the private placement of September 2000. The BCF must be capitalized and amortized from the closing date until the earliest date that the investors have the right to convert the debt into common shares. The BCF in 2000 was computed at approximately $1.8 million, all of which was amortized and included as interest                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            

|F-16
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | expense in the year ending December 31, 2000. Two of the eight investors of the March 2003 private
  placement were also holders of the remaining $3.5 million September 2000 Convertible Debenture offering,
  which was ultimately redeemed for approximately $4.0 million, which includes
  accrued interest. The September 2000 Convertible Debenture holders chose not to convert the
  existing debt to common equity. Instead, the September 2000 Convertible Debenture holders opted to
  be repaid early and participate in a new round of financing. For the
  two investors, the sale of the common stock and warrants reduced the conversion price of the outstanding
  debt, which resulted in an additional BCF charge of approximately $2.7 million during the
  first quarter ending March 31, 2003. The total related BCF charge since inception of the debt of
  $3.5 million was redeemed in the first quarter of 2003 as a result of the debt being repaid. The
  impact of the reversal of the total BCF charge since inception of the debt resulted in a net
  credit of $786,000 recorded as interest income during the first quarter ending March
  31, 2003. This accounting treatment is in accordance with EITF 00-27.
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|                                             
|---------------------------------------------
|9.     Stockholders Equity Stock Transactions
|                                             

| | 2004 Transactions                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| | The Company issued 953,159 shares of its common stock with gross proceeds of $1,720,826 from the exercise
  of options and warrants by employees, former employees, board of directors and consultants. During
  2004, the Company incurred non-cash charges of approximately $133,000, excluding those provided to
  the former CFO, in return for consulting services associated with former employees and certain other
  consultants.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| | During, 2004, the Company issued 9,493 shares of common stock with gross proceeds of $28,999 pursuant
  to the Pharmos Corporation 2001 Employee Stock Purchase Plan. All full-time and part-time employees
  of the Company who have completed a minimum of 6 months of employment are eligible to participate.
  The price of the Common Stock is calculated at 85% of the lower of either the mean between the highest
  and lowest prices at which Pharmos common stock trades on the first business day of the month, or
  the mean between the highest and lowest trading prices on the day of exercise (the last day of the
  month). A participant can purchase shares not to exceed 10% of ones annualized base pay; $25,000;
  or 5% or more of shares outstanding. The total number of shares reserved for issuance under the 2001
  Plan is 500,000 shares. As of December 31, 2004, there were 437,204 shares remaining for issuance
  under the 2001 Plan.                                                                                                                                                                                                                                                                                                                                                                                                                              
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| | As of December 31, 2004, the Company had reserved 1,207,540 common shares for the possible conversion
  of the convertible debentures (including interest) issued in September 2003, 4,592,879 for outstanding
  stock options and 6,915,940 for outstanding warrants.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| | On September 6, 2004, the Board of Directors approved the Retention Award Agreements and Pharmos entered
  into Retention Award Agreements with each of Dr. Haim Aviv, Chairman and Chief Executive Officer,
  and Dr. Gad Riesenfeld, President and Chief Operating Officer. The Company granted retention awards
  of $300,000 cash and 379,747 restricted stock units to Dr. Aviv and $200,000 cash and 253,165 shares
  of restricted stock to Dr. Riesenfeld (the Awards). One half of the Awards shall vest or are scheduled
  to vest and become non-forfeitable on December 31, 2005, and the balance shall vest and become non-forfeitable
  on June 30, 2007, subject to certain accelerated vesting provisions. The fair value of the restricted
  stock awards was based on the fair value of the underlying stock on the issuance date. The aggregate
  fair value of the restricted stock awards totaled $2 million. For financial reporting purposes, the
  cash awards and the fair value of the restricted stock awards, which totaled $2,500,000, will be
  expensed pro rata over the vesting periods. During 2004, the Company recorded an expense of approximately
  $460,000 in connection with the Awards. Per the Awards, only Dr. Riesenfeld was issued shares of
  restricted stock. Dr. Aviv received restricted stock units and will be issued shares of stock when vested.

|F-17
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | On August 20, 2004, the Company completed a private placement to sell common shares to six investors,

generating total gross proceeds of $16.75 million. An aggregate of 5,583,334 shares of common stock

were issued utilizing a shelf registration of Pharmos securities declared effective by the

Securities and Exchange Commission in December 2003 and was priced at $3.00 per share. Issuance
  costs
  of approximately $1,067,000 were recorded as a reduction of additional paid in capital.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | In June 2004, the shareholders of the Company approved the increase in the number of authorized shares
  of the Companys Common Stock to 150,000,000 from 110,000,000.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | In May 2004, the Companys Chief Financial Officer resigned and became a non-paid consultant through
  the end of the year. In accordance with the incentive option plan, all terminated employees who are
  extended a consulting contract may continue to vest their options. Since the former chief financial
  officer became a consultant on a prospective basis, the options outstanding on the date of termination
  are marked to market each quarter until the options vest. The Company recorded the value of the services
  being received based on the fair market value of the options using the Black Scholes option-pricing
  model. The fair value of these options has been estimated based on the following assumptions: volatility
  of 89%, risk free rate of 2.82% - 3.69%, and a zero dividend yield. For the year ended December 31,
  2004, the Company recorded general and administrative expenses of approximately $445,000 in conjunction
  with these options.                                                                                                                                                                                                                                                                                                                                      
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | In January 2004, the underwriters of the December 2003 public offering exercised their over-allotment
  option in full to purchase an aggregate of 1,575,000 shares of Pharmos common stock at a purchase
  price of $2.75 per share, less the underwriting discount. Total net proceeds from the offering, including
  $4.04 million from the exercise of the over-allotment option, were approximately $31.0 million.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | 2003 Transactions                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | The Company issued 3,992,845 shares of its common stock upon the exercise of stock options and warrants,
  and received consideration of $6,298,014.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | During, 2003, the Company issued 29,919 shares of common stock with gross proceeds of $39,891 pursuant
  to the Pharmos Corporation 2001 Employee Stock Purchase Plan.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | In December 2003, the Company completed a public offering. Pharmos sold 10,500,000 common shares at
  a purchase price of $2.75 per share for gross proceeds of $28,875,000. The stock was offered in a
  firm commitment underwriting pursuant to an existing shelf registration statement. The net proceeds
  of this offering to Pharmos were approximately $26.9 million.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | On May 30, 2003, the Company completed a private placement to sell common shares and warrants to ten
  investors, generating total gross proceeds of $8.0 million. The Company filed a registration
  statement with the Securities and Exchange Commission to permit resales of the common stock by the
  investors. The private placement offering was completed by issuing 9,411,765 shares of common stock
  at a price of $0.85 per share (representing an approximate 20% discount to a ten-day trailing average
  of the closing price of the stock ending May 28, 2003) and 3,264,706 warrants at an exercise price
  of $1.40 per share, which includes 441,177 placement agent warrants. Issuance costs of approximately
  $525,000 in cash and $240,000 for the value of the placement agent warrants were recorded as a debit
  to additional paid in capital. The Company calculated the value of the warrants, including the placement
  agent warrants, being approximately $1,773,000 under the Black-Scholes option pricing method (assumption:
  volatility 75%, risk free rate 3.15% and zero dividend yield). As of December 31, 2004, warrant holders
  have exercised 1,947,059 warrants totaling approximately $2,726,000. During 2004, 247,058 warrants
  were exercised totaling approximately $345,881.
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | On March 4, 2003, the Company completed a private placement to sell common shares and warrants to eight
  investors, generating total gross proceeds of $4.3 million under a shelf registration. The private                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

|F-18
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | placement offering was completed by issuing 5,058,827 shares of common stock at a price of $0.85 per
  share (the fair market value on March 4, 2003) and 1,141,182 warrants at an exercise price of $1.25
  per share, which includes 129,412 placement agent warrants. Issuance costs of approximately $127,000
  in cash and $45,000 for the value of the placement agent warrants were recorded as a debit to additional
  paid in capital. As of December 31, 2004, warrant holders have exercised 823,533 warrants totaling
  approximately $1,029,000. There were no warrants exercised in 2004.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | According to EITF 00-19, the warrants issued in March 2003 meet the requirements of and will be accounted
  for as a liability since registered shares must be delivered upon settlement. The Company calculated
  the initial value of the warrants at the date of the transaction, including the placement agent warrants,
  being approximately $394,000 under the Black-Scholes option-pricing method (assumption: volatility
  75%, risk free rate 2.88% and zero dividend yield). The value of the warrants is being marked to
  market each reporting period as a derivative gain or loss until exercised or expiration and has a
  value of $297,955 at December 31, 2004. Upon exercise of each of the warrants, the related liability
  is removed by recording an adjustment to additional paid-in-capital. Since issuance, a total of $936,156
  was recorded as a credit to additional paid-in-capital as result of exercises totaling approximately
  $1.3 million and the recording of the initial value of the warrants of approximately $394,000.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | As of December 31, 2003, the Company had reserved 5,198,020 common shares for the possible conversion
  of the convertible debentures issued in September 2003, 3,771,968 for outstanding stock options and
  7,722,997 for outstanding warrants.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | 2002 Transactions                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | During, 2002, the Company issued 23,384 shares of common stock with gross proceeds of $20,756 pursuant
  to the Pharmos Corporation 2001 Employee Stock Purchase Plan.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | On October 23, 2002, the Board of Directors of the Company approved a stockholder rights plan as set
  forth in the Rights Agreement, dated as of October 23, 2002, between the Company and American Stock
  Transfer & Trust Company, as Rights Agent. Under the Rights Agreement, each common stockholder
  of record as of the close of business on November 6, 2002, received a dividend of one right for each
  share of common stock held. Each right entitled the holder to purchase from the Company one one-thousandth
  of a share of a new series of participating preferred stock at an initial purchase price of $15.00.
  The plan is designed to impose a significant penalty upon any person or group that acquires 15% or
  more of our outstanding common stock without the approval of our board. The stockholder rights are
  triggered either ten days after a third party announces its acquisition of 15% or more of the Companys
  common stock or ten business days after someone starts a tender offer to acquire such amount of shares.
  At that time, all stockholders, other than the person who acquired the block or started the tender
  offer, will have the right for 60 days, upon payment of $15, to purchase $30 worth of common stock
  of the Company, in substitution for the new preferred stock authorized by the stockholder rights
  plan, at the time current market price. As a result, the stockholders of the Company will be able
  to purchase a large number of shares at a discount, significantly diluting the interest of the acquiring
  person and making it significantly more expensive for that person to acquire control of the Company.

|F-19
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
10. Warrants
|-----------------------------------------------------------------------------
|                                                                             

| | Some of the warrants issued in connection with various equity financing and related transactions contain
  anti-dilution provisions requiring adjustment. The following table summarizes the common shares issuable
  upon exercise of warrants outstanding at December 31, 2004 as adjusted for the events which have
  triggered anti-dilution provisions contained in the respective warrant agreements:
| | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                            

|                                 | Under
      Warrants |            | Weighted
      Average
      Exercise Price |  
|-------------------------------- | -------------------- | ---------- | ------------------------------------------- | -
|                                 |                      |            |                                             |  
|Warrants Outstanding at 12/31/01 |                      | 2,297,277  |                                             | $
|Granted                          |                      | 47,553     |                                             | $
|Cancelled                        |                      | (10,000    | )                                           | $
|                                 |                      |            |                                             |  
|                                 |                      |           
|Warrants Outstanding at 12/31/02 |                      | 2,334,830  |                                             | $
|                                 |                      |            |                                             |  
|                                 |                      |           
|Granted                          |                      | 9,920,593  |                                             | $
|Exercised                        |                      | (3,831,533 | )                                           | $
|Cancelled                        |                      | (700,893   | )                                           | $
|                                 |                      |            |                                             |  
|                                 |                      |           
|Warrants Outstanding at 12/31/03 |                      | 7,722,997  |                                             | $
|                                 |                      |            |                                             |  
|Exercised                        |                      | (807,057   | )                                           | $
|                                 |                      |            |                                             |  
|                                 |                      |           
|Warrants Outstanding at 12/31/04 |                      | 6,915,940  |                                             | $
|                                 |                      |            |                                             |  
|Warrants exercisable at 12/31/04 |                      | 6,915,940  |                                             | $
|                                 |                      |            |                                             |  
|Warrants exercisable at 12/31/03 |                      | 7,722,997  |                                             | $
|                                 |                      |            |                                             |  
|Warrants exercisable at 12/31/02 |                      | 2,334,830  |                                             | $
|                                 |                      |            |                                             |  

|         | 
|-------- | 
|         | 
|**Date** | 
|         | 
|2005     | 
|2006     | 
|2007     | 
|2008     | 
|         | 
|Total    | 
|         | 

|                                                                                                                                                                                                   
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|As of December 31, 2004 and 2003, the price per share of the warrants with anti-dilutive provisions
was $4.53 and $4.95, respectively. The 379,856 anti-dilutive warrants expire in September 2005.

|F-20
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
11.   Stock Option Plans
|-----------------------------------------------------------------------------------------
|                                                                                         

| | The Companys shareholders have approved incentive stock option plans for officers and employees.
  The Companys shareholders have approved nonqualified stock options for key employees, directors
  and certain non-employee consultants. Options granted are generally exercisable over a specified
  period, not less than one year from the date of grant, generally expire ten years from the date of
  grant and vest evenly over four years.                                            
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | A summary of the various established stock options plans are as follows:                                                                                                                                                                                                                                                                                                                                                                                                                         
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | 1992 Plan.  The maximum number of shares of the Companys Common Stock available for issuance
  under the 1992 Plan was 750,000 shares, subject to adjustment in the event of stock splits, stock
  dividends, mergers, consolidations and the like. As of December 31, 2004, there were 60,833
  options outstanding to purchase the Companys Common Stock under this plan. Each option granted
  which is outstanding under the 1992 plan as of December 31, 2004 expires on October 31, 2005.
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | 1997 Plan and 2000 Plan. The 1997 Plan was and the 2000 Plan is administered by a committee appointed
  by the Board of Directors (the Compensation Committee). The Compensation Committee will
  designate the persons to receive options, the number of shares subject to the options and the terms
  of the options, including the option price and the duration of each option, subject to certain limitations.                                                                            
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | The maximum number of shares of Common Stock available for issuance under the 1997 Plan was 1,500,000
  shares, as amended, and under the 2000 Plan is 6,000,000 shares, as amended. Each plan is subject
  to adjustment in the event of stock splits, stock dividends, mergers, consolidations and the like.
  Common Stock subject to options granted under the 1997 Plan and the 2000 Plan that expire or terminate
  will again be available for options to be issued under each Plan.      
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | All stock option grants during 2004 were made from the Pharmos Corporation 2000 Incentive and Non-Qualified
  Stock Option Plan.                                                                                                                                                                                                                                                                                                                                                                 

|F-21
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | The following table summarizes activity in approved stock options approved by the Companys Board
  of Directors:
| | -----------------------------------------------------------------------------------------------------------------

|                                |                    |          
|------------------------------- | ------------------ | ---------
|                                | Under
      Option |          
|                                |                    |          
|Options Outstanding at 12/31/01 |                    | 2,448,280
|Granted                         |                    | 872,000  
|Cancelled                       |                    | (228,825 
|                                |                    |          
|                                |                    |          
|                                |                    |          
|Options Outstanding at 12/31/02 |                    | 3,091,455
|                                |                    |          
|                                |                    |          
|                                |                    |          
|Granted                         |                    | 967,500  
|Exercised                       |                    | (161,312 
|Cancelled                       |                    | (106,194 
|                                |                    |          
|                                |                    |          
|                                |                    |          
|Options Outstanding at 12/31/03 |                    | 3,791,449
|                                |                    |          
|Granted                         |                    | 1,387,075
|Exercised                       |                    | (856,349 
|Cancelled                       |                    | (362,208 
|                                |                    |          
|                                |                    |          
|                                |                    |          
|Options Outstanding at 12/31/04 |                    | 3,959,967
|                                |                    |          
|Options exercisable at 12/31/04 |                    | 2,099,118
|                                |                    |          
|Options exercisable at 12/31/03 |                    | 2,050,875
|                                |                    |          
|Options exercisable at 12/31/02 |                    | 1,532,655
|                                |                    |          

|                                                                                                           
|-----------------------------------------------------------------------------------------------------------
|Additional information with respect to the outstanding stock options as of December 31, 2004 is as follows:
|                                                                                                           

|                             | Options Outstanding |                           | Options Exercisable |                                                              
|---------------------------- | ------------------- | ------------------------- | ------------------- | -------------------------------------------------------------
|                             |                     |                           |                     |                                                              
|Range of Exercise
    Prices |                     | Options
      Outstanding |                     | Weighted
      Average
      Remaining
      Contractual Life
|                             |                     |                           |                     |                                                              
|$0.79 - $1.88                |                     |                           | 1,230,526           |                                                              
|$1.90 - $2.50                |                     |                           | 604,166             |                                                              
|$2.78 - $4.24                |                     |                           | 2,125,275           |                                                              
|                             |                     |                           |                     |                                                              
|                             |                     |                           | 3,959,967           |                                                              

|F-22
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | The Company applies Accounting Principles Board Opinion No. 25, Accounting for Stock Issued to Employees,
  and related interpretations in accounting for its plans.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
| | During 2001, the Company issued 453,500 incentive stock options and 100,000 non-qualified stock options
  to employees and directors at an exercise price of $1.88 per share. The exercise price of $1.88 was
  representative of the average price during the month the options were granted, but was below the
  closing market price on the date of the grant. Accordingly, the Company recorded an initial compensation
  expense of $34,594 and deferred compensation expense of $207,563 to reflect the difference between
  the exercise price and the closing market price on the date of the grant. The deferred compensation
  expense is being amortized over the four-year vesting period. Total compensation expense was $53,328,
  $53,328, and $52,981 for the years ending 2004, 2003, and 2002, respectively.
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
| | During 2004, the Company issued 70,000 incentive stock options and 30,000 non-qualified stock options
  to two employees at an exercise price of $3.50 per share. The exercise price of $3.50 was the price
  of the stock on December 31, 2003 but was below the closing market price on the date of the grant.
  Accordingly, the Company recorded a deferred compensation expense of $74,000 to reflect the difference
  between the exercise price and the closing market price on the date of the grant. The deferred compensation
  expense is being amortized over the four-year vesting period. Total compensation expense during 2004
  was $18,560.                                                                                                                                                                 
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
| | On September 6, 2004, the Board of Directors approved the Retention Award Agreements and Pharmos entered
  into Retention Award Agreements with each of Dr. Haim Aviv, Chairman and Chief Executive Officer,
  and Dr. Gad Riesenfeld, President and Chief Operating Officer. The Company granted retention awards
  of 379,747 restricted stock units to Dr. Aviv and 253,165 shares of restricted stock to Dr. Riesenfeld
  (the Awards). One half of the Awards shall vest or are scheduled to vest and become non-forfeitable
  on December 31, 2005, and the balance shall vest and become non-forfeitable on June 30, 2007, subject
  to certain accelerated vesting provisions. The Awards of restricted stock are not included in the
  above stock option table.                                                     
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
| | Fair value of options:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
| | For disclosure purposes under SFAS No. 123, the fair value of each option grant was estimated on the
date of grant using the Black-Scholes option valuation model with the following weighted-average
assumptions:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               

|                          | Year Ended December 31, |              
|------------------------- | ----------------------- | -------------
|                          |                         | 2004         
|                          |                         |              
|Risk-interest rates       |                         | 3.07  3.69 %
|Expected lives (in years) |                         | 5            
|Dividend yield            |                         | 0 %          
|Expected volatility       |                         | 88 - 89%     

|                   
|-------------------
|12. Related Parties
|                   

| | The Companys Pharmos Ltd. subsidiary renewed a License Agreement with Herbamed, Ltd., a company
  controlled by the Companys Chairman and Chief Executive Officer. The License Agreement licenses
  to Herbamed the Companys patent rights for the oral delivery of lipophilic substances in the
  limited field of nutraceuticals, which include food and dietary supplements, food additives, vitamins
  and herbs. Under the terms of the revised License Agreement, Herbamed will pay to Pharmos Ltd. royalties
  of 6% on net sales of up to $20 million, 5% on net sales between $20 million and $50 million and
  4% on net sales in excess of $50 million. During 2004, 2003 and 2002, the Company recognized
  other income of $9,008, $4,355 and $0, respectively, per the licensing agreement with Herbamed.
| | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|F-23
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
13.   Income Taxes
|-----------------------------------------------------------------------------------
|                                                                                   

| | For 2004, 2003 and 2002, the Company has not recorded a tax benefit on the operating losses generated
  by U.S and Israeli operations. After an assessment of all available evidence, including historical
  and forecasted operating results, management has concluded that realization of the Companys
  net operating loss carryforwards (NOLs) and other deferred tax assets could not be considered
  more likely than not. Based on this assessment, the Company has increased the valuation allowance
  established on deferred tax assets by approximately $8,080,000, $4,711,000, and $ 7,351,000 in 2004,
  2003 and 2002, respectively.
| | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
| | During 2004, 2003 and 2002, the Company sold a portion of its accumulated New Jersey NOLs to a third
  party under New Jerseys Technology Business Tax Certificate Transfer program. Accordingly,
  tax benefits of $444,774, $227,798 and $215,223, respectively, were recognized from the sales.                                                                                                                                                                                                                                                                                                                                                  
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
| | For 2004, 2003 and 2002, the Companys recorded tax benefit differs from the benefit calculated
  by applying the statutory U.S. federal income tax rate due to the valuation allowances established
  on deferred tax assets in those periods, offset by the aforementioned tax benefits from the sale
  of New Jersey NOLs.                                                                                                                                                                                                                                                                                                                        
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
| | At December 31, 2004 and 2003, the Companys deferred tax assets are comprised of the following:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      

|                                              | 2004 |             | 2003 |  
|--------------------------------------------- | ---- | ----------- | ---- | -
|                                              |      |             |      |  
|Domestic NOLs                                 | $    | 43,350,000  |      | $
|Israeli NOLs                                  |      | 914,000     |      |  
|Research and Development Credit Carryforwards |      | 2,940,000   |      |  
|Deferred Research and Development Costs       |      | 216,000     |      |  
|Accrued expenses and other                    |      | 325,000     |      |  
|                                              |      |             |      |  
|Net Deferred Tax Assets                       |      | 47,745,000  |      |  
|Valuation Allowance                           |      | (47,745,000 | )    |  
|                                              |      |             |      |  
|                                              | $    |            |      | $
|                                              |      |             |      |  

| |                                                                                                                                                                                                                                                                                                                                                                                                                                                     
| | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| | At December 31, 2004 the Company had net operating losses of approximately $121 million, $39 million
      and $3 million for U.S., New Jersey and Israel, respectively, tax return purposes. As a result of
      previous business combinations and changes in its ownership, there is a substantial amount of U.
      S. NOLs that are subject to annual limitations on utilization. The U.S. NOLs begin to expire in 2006
    and through 2024.

|                                 
|---------------------------------
|14. Commitments and Contingencies
|                                 

| | Leases                                                                                                                                                                                
| | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                       
| | The Company leases research and office facilities in Israel and New Jersey. The facilities in Israel
  are used in the operation of the Companys research and development activities.
| |                                                                                                                                                                                       
| | All of the leases described above call for base rentals, payment of certain building maintenance costs
  (where applicable) and future increases based on the consumer price indices. 

|F-24
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | At December 31, 2004, the future gross minimum lease commitments with respect to non-cancelable operating
  leases (including office and equipment leases) with initial terms in excess of one year are as follows:
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                    

|     | Lease
      Commitments |          
|---- | ----------------------- | ---------
|     |                         |          
|2005 | $                       | 651,997  
|2006 |                         | 621,867  
|2007 |                         | 242,502  
|2008 |                         | 216,467  
|2009 |                         | 216,467  
|     |                         |          
|     |                         |          
|     | $                       | 1,949,300
|     |                         |          

| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| | Rent expense during 2004, 2003 and 2002 amounted to $556,308, $501,665, and $467,879, respectively.
  In 2004, 2003 and 2002, rent expense is net of sublease income of $97,630, $97,630 and $81,358, respectively.
  The sublease agreement expires on March 31, 2007 and is at an annual rate of $97,630.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| | Clinical service fees                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| | The Company has certain professional clinical service fees relating to the Phase III clinical study
  for dexanabinol for traumatic brain injury. Upon the completion of certain agreed upon milestones,
  additional fees will be paid. The maximum amount that could be paid is approximately $11.1 million
  and is not committed beyond 2004. Through December 31, 2004, the Company has recorded $11.0 million
  as an expense. During 2004, 2003 and 2002, the Company recorded expenses of $2.0 million, $4.2 million
  and $2.5 million, respectively.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| | Consulting contracts and employment agreements                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| | In the normal course of business, the Company enters into annual employment and consulting contracts
  with various employees and consultants.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| | Dividend restrictions                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| | Dividends may be paid by the Companys subsidiary, Pharmos Limited, only out of retained earnings
  as determined for Israeli statutory purposes. There are no retained earnings in Israel available
  for distribution as dividends as of December 31, 2004, 2003 or 2002.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| | Litigation                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
| | The Company and three current officers have been named as defendants in several purported shareholder

class action lawsuits alleging violations of federal securities laws. These lawsuits were filed
  beginning
  in January 2005 and are pending in the U.S. District Court for the District of New Jersey.
  These
  lawsuits assert claims under Sections 10(b) and 20(a) of the Securities Exchange Act of 1934
  and
  Rule 10b-5 thereunder on behalf of a class of purchasers of our common stock during the period
  from
  June 9, 2003 through and including December 20, 2004 (the Class Period). The complaints

allege generally that the defendants knowingly or recklessly made false or misleading statements

during the Class Period regarding the effectiveness of dexanabinol in treating TBI which had the

effect of artificially inflating the price of our shares. The complaints seek unspecified damages.

Pharmos believes the complaints are without merit and intends to defend these lawsuits vigorously.

However, we cannot assure you that we will prevail in these actions, and, if the outcome is unfavorable

to Pharmos, our reputation, profitability and share price could be adversely affected.

|F-25
|----



|Pharmos Corporation
  Notes to Consolidated Financial Statements
|----------------------------------------------------------------
|                                                                

| | In addition, a purported shareholder of Pharmos common stock has commenced a derivative action against


    certain officers and directors of Pharmos. This lawsuit was commenced in February 2005 in the
    U.S.

District Court for the District of New Jersey. It alleges, on behalf of Pharmos (which has
    been
    named
    as a nominal defendant), breaches of fiduciary duty and other State law violations.
    The Complaint

seeks unspecified damages. Pharmos believes that the derivative action is without
    merit, and intends

to take all appropriate action in respect of the derivative action.
| | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|                            
|----------------------------
|15.   Employee Benefit Plans
|                            

| | The Company has a 401-K defined contribution profit-sharing plan covering its U.S. employees.
  Contributions to the plan are based on employer contributions as determined by the Company and allowable
  discretionary contributions, as determined by the Companys Board of Directors, subject to certain
  limitations. Contributions by the Company to this plan amounted to $58,926, $51,893, and $45,296
  in 2004, 2003 and 2002, respectively.                                                                                                        
| | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
| | Pharmos Ltd. participates in various contribution severance plans and makes regular deposits with pension
  funds or insurance companies to allow some severance rights to most of its employees. The custody
  and management of the amounts so deposited are independent of the Company. The Company is required
  by Israeli labor laws to pay upon dismissal or retirement each employee one month of salary for each
  year of service. The Company generally funds this liability by purchasing insurance policies directly
  in the name of each employee.

|                                        
|----------------------------------------
|16.   Segment and Geographic Information
|                                        

| | The Company is active in one business segment: designing, developing, selling and marketing pharmaceutical
  products. The Company maintains development operations in the United States and Israel. The Companys
  administration operations are maintained in the United States. The Companys chief operating
  decision makers use measurements aggregated at the entity-wide level to manage the business. Reflected
  in the numbers below are intercompany billings from Israel to the United States for research and
  development activity.
| | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
| | Geographic information for the years ending December 31, 2004, 2003 and 2002 are as follows:                                                                                                                                                                                                                                                                                                                                                                                                                                                         
| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      

|                          | 2004 |             | 2003 |   | 2002        |  
|------------------------- | ---- | ----------- | ---- | - | ----------- | -
|                          |      |             |      |   |             |  
|Net loss                  |      |             |      |   |             |  
|United States             | $    | (21,545,126 | )    | $ | (17,943,150 | )
|Israel                    |      | (422,641    | )    |   | (542,715    | )
|                          |      |             |      |   |             |  
|                          | $    | (21,967,767 | )    | $ | (18,485,865 | )
|                          |      |             |      |   |             |  
|Total assets              |      |             |      |   |             |  
|United States             | $    | 53,352,426  |      | $ | 66,203,358  |  
|Israel                    |      | 4,312,416   |      |   | 3,419,124   |  
|                          |      |             |      |   |             |  
|                          | $    | 57,664,842  |      | $ | 69,622,482  |  
|                          |      |             |      |   |             |  
|Long lived assets, net    |      |             |      |   |             |  
|United States             | $    | 156,750     |      | $ | 160,033     |  
|Israel                    |      | 1,661,573   |      |   | 1,730,063   |  
|                          |      |             |      |   |             |  
|                          | $    | 1,818,323   |      | $ | 1,890,096   |  
|                          |      |             |      |   |             |  
|Capital expenditures, net |      |             |      |   |             |  
|United States             | $    | 124,860     |      | $ | 32,396      |  
|Israel                    |      | 185,186     |      |   | 84,995      |  
|                          |      |             |      |   |             |  
|                          | $    | 310,046     |      | $ | 117,391     |  
|                          |      |             |      |   |             |  

|F-26
|----



|Pharmos Corporation
      Notes to Consolidated Financial Statements
    17.   Quarterly Information (Unaudited)
|----------------------------------------------------------------------------------------------------------------
|                                                                                                                

|Year ended
      December 31, 2004 |  | 1st Quarter |            | 2nd Quarter |   | 3rd Quarter |   | 4th Quarter |           
|---------------------------------- |  | ----------- | ---------- | ----------- | - | ----------- | - | ----------- | ----------
|                                   |  |             |            |             |   |             |   |             |           
|Operating Expenses1,2              |  | $           | 4,488,435  |             | $ | 4,359,918   |   | $           | 5,661,913 
|Loss from Operations               |  |             | (4,488,435 | )           |   | (4,359,918  | ) |             | (5,661,913
|Other (Expense) Gain, net4,5       |  |             | (1,452,366 | )           |   | (925,383    | ) |             | (280,996  
|Net loss6                          |  | $           | (5,940,801 | )           | $ | (5,285,301  | ) | $           | (5,942,909
|Net loss                           |  |             |            |             |   |             |   |             |           
|per share - basic & diluted*       |  | $           | (.07       | )           | $ | (.06        | ) | $           | (.07      

|                                                                                                   
|---------------------------------------------------------------------------------------------------
|*The addition of earnings per share by quarter may not equal total earnings per share for the year.
|                                                                                                   

|Year ended
      December 31, 2003 | 1st Quarter |  | 2nd Quarter |            | 3rd Quarter |   | 4th Quarter |  
|---------------------------------- | ----------- |  | ----------- | ---------- | ----------- | - | ----------- | -
|                                   |             |  |             |            |             |   |             |  
|Operating Expenses2                |             |  | $           | 5,063,580  |             | $ | 3,238,173   |  
|Loss from Operations               |             |  |             | (5,063,580 | )           |   | (3,238,173  | )
|Other Income (Expense), net3,4,5   |             |  |             | 564,375    |             |   | (1,075,946  | )
|Net loss6                          |             |  | $           | (4,499,205 | )           | $ | (4,314,119  | )
|Net loss                           |             |  |             |            |             |   |             |  
|per share - basic & diluted*       |             |  | $           | (.08       | )           | $ | (.07        | )

|  |                                                                                                                                                                        
|- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------
|1 | Includes a non cash option and retention award expense of approximately $ 945,652.                                                                                     
|  |                                                                                                                                                                        
|2 | Fluctuations within operating expenses is primarily related to expenses with the clinical trials and the timing of the receipt of grants.                              
|  |                                                                                                                                                                        
|3 | Other Income (Expense), net and the Net Loss for the first quarter of 2003 include a BCF reversal of $786,000.                                                         
|  |                                                                                                                                                                        
|4 | Interest expense includes accretion of debt discount and the amortization of debt issuance costs associated with the $21 million September 2003 Convertible Debentures.
|  |                                                                                                                                                                        
|5 | Includes the derivative gain of $525,074 in 2004 and a loss of $1,759,183 in 2003.                                                                                     
|  |                                                                                                                                                                        
|6 | Includes the selling of the NJ Net Operating Loss in Q4 2004 and Q4 2003 of $444,744 and $227,798, respectively.                                                       
|  |                                                                                                                                                                        

|*The addition of earnings per share by quarter may not equal total earnings per share for the year.
18.   Subsequent events
|---------------------------------------------------------------------------------------------------------------------------
|                                                                                                                           

| | During January
2005, the Company signed an amendment to its asset purchase agreement with Bausch & Lomb and received a net
milestone payment, after expenses and other contractual obligations, of approximately $9.1 million. The milestone payment
  was triggered by Bausch & Lombs commercial launch of Zylet which was approved for marketing
  by the FDA on December 15, 2004.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
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| |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
| | The Company and three current officers have been named as defendants in several purported shareholder class action lawsuits alleging violations of federal securities laws. These lawsuits were filed beginning
  in January 2005 and are pending in the U.S. District Court for the District of New Jersey. These
  lawsuits assert claims under Sections 10(b) and 20(a) of the Securities Exchange Act of 1934 and
  Rule 10b-5 thereunder on behalf of a class of purchasers of the Companys common stock during
  the period from May 5, 2003 through and including December 17, 2004 (the Class Period).
  The complaints allege generally that the defendants knowingly or recklessly made false or misleading
  statements during the Class Period regarding the effectiveness of dexanabinol in treating TBI which
  had the effect of artificially inflating the price of our shares. The complaints seek unspecified
  damages. Management, based on the advice of counsel, believes the complaints are without merit and intends to defend these lawsuits vigorously.
  However, we cannot assure you that we will prevail in these actions, and, if the outcome is unfavorable
  to Pharmos, our reputation, profitability and share price could be adversely affected.

|F-27
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|Pharmos Corporation
  Notes to Consolidated Financial Statements
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|                                                                

| | In addition, a purported shareholder of Pharmos common stock has commenced a derivative action against certain officers and directors of Pharmos. This lawsuit was commenced in February 2005 in the
  U.S. District Court for the District of New Jersey. It alleges, on behalf of Pharmos (which has
  been named as a nominal defendant), breaches of fiduciary duty and other State law violations.
  The Complaint seeks unspecified damages. Management, based on the advise of counsel, believes that the derivative action is without
  merit, and intends to take all appropriate action in respect of the derivative action.
| | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|F-28
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