Study Director: [ ] 

Test Facility: [ ] 

Sponsor: [ ] 

1 Study Number: 41301944 

Study Completion Date: 03 September 2013 

Page 1 of 18 
1.1 Guidelines I Regulations .......................................................................................... 7 

2 TEST ITEM ........................................................................................................................... 8 

3 TESTS .................................................................................................................................... 9 

3.1 Flash Point ............................................................................................................... 9 

3.1.1 Test System ............................................................................................... 9 

3.1.2 Principle ofthe Test ................................................................................... 9 

3 .1.3 Performance of the Test ............................................................................. 9 

3 .1.4 Data Handling ............................................................................................ 9 

3.1.5 Results ..................................................................................................... 10 

3.1.6 Conclusion ............................................................................................... 11 

3.2 Explosive Properties .............................................................................................. 12 

3.2.1 Test System ............................................................................................. 12 

3.2.2 Performance ofthe Prediction ................................................................. 12 

3.2.3 Data Handling .......................................................................................... 12 

3.2.4 Results ..................................................................................................... 12 

3.2.5 Conclusion ............................................................................................... 12 

3.3 Auto-Ignition temperature (Liquids and Gases) .................................................... 13 

3.3.1 Test System ............................................................................................. 13 

3.3.2 Principle of the Test ................................................................................. 13 

3.3.3 Performance ofthe Test ........................................................................... 13 

3.3.4 Data Handling .......................................................................................... 13 

3.3.5 Results ..................................................................................................... 14 

3.3.6 Conclusion ............................................................................................... 15 

3.4 Oxidizing Properties (Liquids) .............................................................................. 16 

3.4.1 Test System .......................................................................... .' .................. 16 

3.4.2 Performance ofthe Prediction ................................................................. 16 

3.4.3 Data Handling .......................................................................................... 16 

3.4.4 Results ..................................................................................................... 16 

3.4.5 Conclusion ............................................................................................... 16 

APPENDICES ............................................................................................................................... 17 

Appendix 1 Compositional Information .................................................................................... 17 

Appendix 2 Monitoring Authority Statement of GLP Compliance .......................................... 18 
perfonned in compliance with UK GLP standards (Schedule I, Good Laboratory Practice 

Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)). These Regulations are in 

accordance with GLP standards published as OECD Principles on Good Laboratory Practice 

(revised 1997, ENV /MC/CHEM(98) 17); and are in accordance with, and implement, the 

requirements of Directives 2004/9/EC and 2004/10/EC. 

These principles are compatible with Good Laboratory Practice regulations specified by 

regulatory authorities throughout the European Community, the United States (EPA and FDA), 

and Japan (MHLW, MAFF and MET!). 

This report fully and accurately reflects the procedures used and data generated. There were no 

circumstances considered to have affected the integrity of the study or the validity of the data. 

Study Director: [ ] 

[ ] 

Date: 

-3 SEP 2013 
these audits and inspections are given below. 

Reported to the relevant 

Dates and Types ofQA Inspections Study Director and Test 

Facility Management 

Date of Inspection Type of Inspection Phase Inspected Report Date 

24 May 2013 Study Plan Verification N/A 24 May2013 

29 July 2013 Process - based Flash Point 29 July 2013 

02, 15 July 2013 Process - based Auto-Ignition Temperature 02, 15 July 2013 

(Liquids and Gases) 

2 1 August 2013 Report Audit N/A 21 August2013 

This statement confirms that this final report reflects the raw data and the procedures followed. 

Quality Assurance: 

[ ] 

Date: ~ 0 4 SEP 2013 
Auto-Ignition Temperature (Liquids and Gases). 358 ± 5 °C, using a procedure designed to be 

compatible with Method A15 Auto-Ignition Temperature (Liquids and Gases) of Commission 

Regulation (EC) No 440/2008 of 30 May 2008. 

Oxidizing Properties (Liquids). Predicted negative based on the chemical structure of the test 

item, using a procedure designed to be compatible with Method A21 Oxidising Properties 

(Liquids) of Commission Regulation (EC) No 440/2008 of 30 May 2008. 
Archiving 

Unless instructed otherwise by the Sponsor, the study plan (General Study Plan and Study 

Specific Supplement), all raw data (paper and electronic) and the final report will be retained in 

the [ ] archives for five years after which instructions will 

be sought as to turther retention or disposal. Further retention or return of the data will be 

chargeable to the Sponsor. 

No data will be discarded without contacting the Sponsor to obtain their written consent. 
• Commission Regulation (EC) No 440/2008 (as amended) of 30 May 2008, Part A: 

Methods for the determination of physico-chemical properties. 
Structure: 

Expiry Date: 

Storage Conditions: 

Information on the detailed composition is provided in appendix 

1. 

30 January 2015 

Room temperature, under nitrogen in the dark 
Instrument: Setaflash flash point tester 30000-0. 

3.1.2 Principle of the Test 

The test item is placed into the apparatus and progressively heated until the vapor reaches a 

sufficiently high concentration in air to produce a flammable mixture which can be ignited. 

3.1.3 Performance of the Test 

An aliquot (approximately 2 g for temperatures up to 100 °C and approximately 4 g for 

temperatures above 100 °C) of the test item was transferred to the sample cup of the Setaflash 

30000-0 tester. The sample was heated and allowed to equilibrate at the set temperature. The 

test flame was introduced into the sample cup for approximately 2Yz seconds by sliding the cup 

shutter open. Observations were made for ignition of the vapor. If no ignition occurred, the 

temperature was increased and the test flame re-introduced. This was repeated until the lowest 

reproducible temperature at which a flash occurred, using a fresh sample, was determined. 

3.1.4 Data Handling 

The flash point is the lowest temperature at 1 01.3 kPa, at which the test liquid in a closed test 

vessel evolves vapors, under the conditions defmed in the test method, in such an amount that a 

flammable vapor I air mixture was produced in the test vessel. 

1 Based on, Anon (1983) Paints, Varnishes, Petroleum and Related Products- Determination ofFlash Point· Rapid Equilibrium Method, lnternadonal Standard ISO 3679-2004 (E), Second Edition- 2004-04-01, Pl-18 and Anon (1989) Flash Point of 

Liquids by Setaflash Closed·CupApparatus,ASTM D-3278-89, Pl-7. 
3.1.5 Results 

Results of the flash point determination are shown in the following table. 

Table 3.1 

Temperature (0C) Observations 

25.0 No flash. 

30.0 No flash. 

35.0 No flash. 

40.0 No flash. 

45.0 No flash. 

50.0 No flash. 

55.0 No flash. 

60.0 No flash. 

65.0 No flash. 

70.0 No flash. 

75.0 No flash. 

75.0 (fresh sample) No flash. 

80.0 No flash. 

85.0 No flash. 

90.0 No flash. 

95.0 No flash. 

100.0 No flash. 

105.0 (fresh sample) No flash. 
140.0 No flash. 

145.0 No flash. 

150.0 No flash. 

155.0 No flash. 

155.0 (fresh sample) No flash. 

160.0 A blue flash spread across the sample cup. 

155.0 (fresh sample) No flash. 

156.0 No flash. 

157.0 No flash. 

158.0 No flash. 

159.0 A blue flash spread across the sample cup. 

159.0 (fresh sample) A blue flash spread across the sample cup. 159.0 (fresh sample) A blue flash spread across the sample cup. 157.0 (fresh sample) No flash. 

157.0 (fresh sample) No flash. 

Atmospheric pressure = 

Corrected flash point = 

101.4 kPa 

158.983 oc 

3.1.6 Conclusion 

The flash point of the test item has been determined to be 159 ± 2 °C. 
p

g

p

, 

, 

, 

g

yg

, 

contiguous nitrogen atoms, N-halogens, 0-halogens, N-0. Examples of these groups are given 

below. 

Structural Features 

C-C unsaturated C-metal, N-metal Contiguous oxygen atoms Contiguous nitrogen atoms 

N-halogens 

0-halogens 

N-0 

Examples 

Acetylenes, acetyl ides, 1,2 - dienes 

Grignard reagents, organo-lithiwn compounds 

Peroxides, ozonides 

Azides, aliphatic azo compounds, diazonium salts, hydrazines, 

sulphonyl hydrazides 

Chloramines, fluoroamines 

Chlorates, perchlorates, iodosyl compounds 

Hydroxylamines, nitrates, nitro compounds, N -oxides, 1 ,2-

oxazoles 

Full structural details are given in Bretherick's Handbook of Reactive Chemical Hazards, 

7th Edition, Academic Press, 2007. 

3.2.3 Data Handling 

If there are no structural alerts within the structure then the explosive properties can be predicted 

negative. 

3.2.4 Results 

There are no structural alerts within the chemical structure of the test item. 

3.2.5 Conclusion 

Based on the chemical structure of the test item the result for the explosive properties has been 

predicted negative. 
c

p

e of the Test 

The auto-ignition temperature is the lowest temperature at which the test item will ignite when 

mixed with air under the conditions defined in the test method. 

3.3.3 Performance of the Test 

The test flask was heated in a flask heater. Aliquots of test item (tested as received) were 

dropped into the flask which was observed for signs of ignition over a 300 second period. This 

procedure was repeated, varying the sample size, as necessary, until the lowest temperature at 

which ignition, if any, occurred within 300 seconds of insertion, was determined. 

3.3.4 Data Handling 

The auto-ignition temperature is the lowest temperature that will result in the ignition of the test 

item. 

The room temperature and atmospheric pressure is recorded for each day of the test. 

2 Based on, Anon (1987), Electrical Apparatus for Explosive Gas Atmospheres. Part 4: Method of Test for Ignition 

Temperature. 1EC Publications 79-4, Pl-19. 
350 (clean flask) 0.1 >300 No ignition. Grey fumes were emitted. 

400 (clean flask) 0.2 2 A yellow flame. Grey fumes were emitted. 

380 0.2 2 A yellow flame. Grey fumes were emitted. 

370 0.1 >300 No ignition. Grey fumes were emitted. 

376 (clean flask) 0.3 3 A yellow flame. Grey fumes were emitted. 

372 0.3 >300 No ignition. Grey fumes were emitted. 

374 0.3 >300 No ignition. Grey fumes were emitted. 

374 (clean flask) 0.2 2 A yellow flame. Grey fumes were emitted. 

372 (clean flask) 0.2 7 A yellow/green flame. Grey fumes were emitted. 

370 (clean flask) 0.2 >300 No ignition. Grey fumes were emitted. 

370 (clean flask) 0.1 >300 No ignition. Grey fumes were emitted. 

370 (clean flask) 0.3 5 A blue/green flame. Grey fumes were emitted. 

368 (clean flask) 0.2 2 A yellow/blue flame. Grey fumes were emitted. 

366 (clean flask) 0.3 4 A yellow/blue flame. Grey fumes were emitted. 

364 (clean flask) 0.3 >300 No ignition. Grey fumes were emitted. 

364 (clean flask) 0.5 >300 No ignition. Grey fumes were emitted. 

364 (clean flask) 0.7 2 A yellow/blue flame. Grey fumes were emitted. 

362 (clean flask) 0.5 >300 No ignition. Grey fumes were emitted. 

362 (clean flask) 0.7 >300 No ignition. Grey fumes were emitted. 

362 (clean flask) 0.8 2 A yellow/blue flame. Grey fumes were emitted. 

360 (clean flask) 0.8 >300 No ignition. Grey fumes were emitted. 

360 (clean flask) 1.1 2 A yellow/blue flame. Grey fumes were emitted. 

358 (clean flask) 0.8 >300 No ignition. Grey fumes were emitted. 
Room temperature: 19 to 21 °C 

Atmospheric pressure:101.0 to 102.1 kPa 

3.3.6 Conclusion 

The test item has been determined to have an auto-ignition temperature of358 ± 5 °C. 
p

p

p

g

p

yp

difluoroaminopolynitroaryls, perchlorates, bromates and iodites. 

Full structural details are given in Bretherick's Handbook of Reactive Chemical Hazards, 

7th Edition, Academic Press, 2007. 

3.4.3 Data Handling 

If there are no structural alerts within the structure then the oxidizing properties can be predicted 

negative. 

3.4.4 Results 

There are no structural alerts within the chemical structure of the test item. 

3.4.5 Conclusion 

Based on the chemical structure of the test item the result for the oxidizing properties has been 

predicted negative. 
. . . 

••••• 

• ••• • ••• 

••••• 

• • 

. 

• 

[ 

] 
STATEMENT OF COMPLIANCE 

IN ACCORDANCE WITH DIRECTIVE 2004/9/EC 

TEST FACILITY TEST TYPE(S) 

[ ] 

DATE OF INSPECTION 

10 July 2012 

Analytical/Clinical 

Chemistry 

Environmental Toxicity 

Environmental Fate 

Mutagenicity 

Phys/Chem. Tests 

Toxicology 

An inspection for compliance with the Principles of Good Laboratory Practice was 

carried out at the above test facility as part of the UK Good Laboratory Practice 

Compliance Monitoring Programme. 

This statement confirms that, on the date of issue, the UK Good Laboratory 

Practice Monitoring Authority were satisfied that the above test facility was 

operating in compliance with the OECD Principles of Good Laboratory Practice. 

This statement constitutes a Good Laboratory Practice Instrument (as defined in the 

UK Good Laboratory Practice Regulations 1999). 

Dr. Andrew J. Gray 

Head, UK GLP Monitoring Authority