UNITED STATES ENVIRONMENTAL PROTECTION AGEN CY WASHINGTON, D
. C. 20460 

## DEC 

# 17 201Z

OFF I CE OF AIR AND RADIATION [ [ [ 

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Re: Incomplete SNAP Submission for [ Dear [ 

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Thank you for [ ] submis sion to the Environmental Protection Agency. The EPA established the Significant New Alternatives Policy program to implement section 612 of the Clean Air Act. We have reviewed for completeness your submission that we received on July 2, 20 12 and additional information received on September 21,2012
. We have found the information to be incomplete. To be able to review your SNAP submission review, EPA require s the fo llowing information : 1
. Clarification of blend compositions. The new substitute is proposed for us e neat and in blends of as little as [ ] The actual blend formulation has the potential to vary widely. Please specify, or at least narrow, the chemicals and percentage of the chemica ls to be used in blends for the solvent cleaning (metal, electronic, and precision cleaning), aerosol (solvent), and adhesives, coatings , and inks uses. 2. Conversion of exposure estimates. In your PowerPoint presentation, you provided estimates ofhuman exposure to the proposed subst itute in units ofmg/kg/day. Please confirm or correct the conversion from mg/kg/day to ppm . Wor ker Inhalation Exposure Estimates Units ofMeasure 

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### [ ] ] mg/kg/day 

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### [ ] [ ] [ ] (provided) ppm calculation 

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Internet Address (UR L) • http
.//www
. epa . gov Recycled/Recyclable ·Printed with Vegetable Oil Base d Inks on 100% Postconsumer
. Process Chlori ne Free Recycl ed Paper ]We e s timated these values based on the following equation: Exposure Estimate [ ' )X 72 [ ] 110 [ ] X 24.45 ( ] I [ ][ ] In addition, please clarify whether these exposure estimates are based on the neat substance only or on a [ ] . 3 . Additional toxicity information. Do you have any 28 - day or 90-day inhalation toxicit y studies c o mpleted for this compound that you could provide? If you have not performed such a st u dy , we request th a t you perform at least a 28-day inhalation toxicity study. If you conduct additional testing , we recommend that the testing include a functional observation

battery o n neurological effects. As inhalation is t he mo s t probable route of exposure , a repeat dose inh a lation study woul d be helpful in fully assessing health effects and redu c ing uncertai n ty. 4. Confidential busines s informatio n (CBI) claims. Claims of CBI, if you wish to claim any of the information above as CBI. Here is a summary of information concerning your submissio n : Substitute na me s: [ ] Name for publication in Federal Register: To be determined Substance(s) the subst i tute will r eplace: CFC - 113 , m e thyl chloroform, HCFC-225ca!cb Sec t or: Solvent Cleaning E nd-uses: m e tals , elec t ronics and precision cleaning Substance(s) the subst i tute will r eplace: CFC - 113, HCFC-141b, HC F C-225ca/cb S e ctor: Aero s ols End-use: solvents Substance(s) the substitute will r eplace: C F C - 113, meth y l chloroform

Sector: Adhe s ives, Coatings and Inks E nd - use: coa t ings Substance(s) the substitute will r eplace: CFC-113 Sector: Refrigeration and Air-Conditioning

End-u s e: non - mechanical heat transf e r Retrofit or new: retrofit and ne w equipmentDate most recent information received: November 20, 2012 Status of submission : incomplete Responses to these questions would be helpful for our review. The information can be submitted via electronic mail if not confidential or via hard copy and/or DVD if your response s contain confidential business information. If you have questions about your submission, please contact me at (202) 343 -9464 or Fiffer.melissa@epa.gov. Sincerely,



# ~w Melissa Fiffer Alternatives and Emiss ions Reduction Branch Stratospheric Protection Division