Clothianidin Dietary Exposure and Risk Assessment

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

 

MEMORANDUM

Date: 26 September 2012

SUBJECT: Clothianidin – Acute and Chronic Dietary Exposure and Risk Estimates for 

Requested Amended Registration on Peppers and New Uses on Strawberry, 

Citrus, Pistachio, and Tea.

PC Code: 044309

Decision No.: 455249

Petition No.: 1E7923

Risk Assessment Type: Dietary 

TXR No.: NA

MRID No.: NA

FROM: Michael A. Doherty, Ph.D., Chemist

Risk Assessment Branch II

Health Effects Division (7509P)

THROUGH: David Hrdy, Branch Chief (acting), RAB I

Jennifer R. Tyler, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Christina Swartz, Branch Chief

Risk Assessment Branch II

Health Effects Division (7509P)

TO: Marianne Lewis/Venus Eagle (RM 01)

Insecticide/Rodenticide 

Registration Division

Barbara Madden

Risk Integration, Minor Use, and Emergency Response Branch

Registration Division (7505P)

Dietary Exposure and Risk Assessment DP Number: 

Page 1 of 17

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND

 POLLUTION PREVENTION

September 2012

Acute and Chronic Dietary Exposure and Risk Estimates for 

Amended Registration on Peppers and New Uses on Strawberry, 

Citrus, Pistachio, and Tea. 

DP Barcode: D397690 

455249 Registration Nos.: 59639

1E7923, 2F8008 Regulatory Action: Amended Registration 

and New Section 3 Registrations

Risk Assessment Type: Dietary Case No.: 7620

CAS No.: 210880-92-5

40 CFR: §180.586

Michael A. Doherty, Ph.D., Chemist

Risk Assessment Branch II

Health Effects Division (7509P)

David Hrdy, Branch Chief (acting), RAB I

Jennifer R. Tyler, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Christina Swartz, Branch Chief

Risk Assessment Branch II

Health Effects Division (7509P)

Marianne Lewis/Venus Eagle (RM 01)

Insecticide/Rodenticide Branch

Division (7505P)

Risk Integration, Minor Use, and Emergency Response Branch

Registration Division (7505P)

DP Number: D397690

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF CHEMICAL SAFETY AND

POLLUTION PREVENTION

Acute and Chronic Dietary Exposure and Risk Estimates for 

Amended Registration on Peppers and New Uses on Strawberry, 

 

59639-150, 59639-152

Amended Registration 

and New Section 3 Registrations
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 2 of 17

Executive Summary

Acute and chronic aggregate dietary (food + drinking water) exposure and risk assessments were 

conducted using the Dietary Exposure Evaluation Model software with the Food Commodity

Intake Database (DEEM-FCID) Version 3.16, which uses food consumption data from the U.S. 

Department of Agriculture’s National Health and Nutrition Examination Survey, What We Eat in 

America, (NHANES/WWEIA). This dietary survey was conducted from 2003 to 2008. The 

analyses were conducted in support of a human health risk assessment of the proposed new 

Section 3 registrations on strawberry, citrus (Crop Group 10-10), pistachio, and tea as well as 

proposed a requested increase in the tolerance for residues in/on Crop Subgroup 8-10B due to a 

label amendment to shorten the pre-harvest interval.

The acute and chronic assessments are based on the screening-level input assumptions, including 

tolerance-level residues, 100% crop treated, and high-end estimates of residues in drinking water 

based on estimated concentrations of clothianidin in rice paddy water. These inputs resulted in 

risk estimates that are, at most, 28% of the population-adjusted dose for all population subgroups 

for both the acute and chronic assessments; the maximum risk estimate is for children 1-2 years 

of age. All dietary risk estimates are below HED’s level of concern. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one 

in one million. References that discuss the acute and chronic risk assessments in more detail are 

available on the EPA/pesticides web site: “Available Information on Assessing Exposure from 

Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for clothianidin was conducted by M. Doherty (1 Feb 

2012, D395798). This is the first assessment conducted using the NHANES/WWEIA

consumption database.

II. Residue Information

The acute and chronic assessments rely on tolerance-level residues (40 CFR 180.586) for all 

crops with registered and/or requested clothianidin uses (Table 1). For crops except leafy

vegetables, the residue of concern for risk assessment purposes is the parent compound. For root 

crops and leafy vegetables, the residues of concern are the parent compound and the TMG 

metabolite. Field trial data show no detectable residues of TMG in root crops and that TMG 

does not exceed 10% of the parent compound residue level in leafy vegetables. A factor of 1.1 
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

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(entered into the model as Adjustment Factor 1) has been incorporated into the assessment for 

leafy vegetables to account for the presence of TMG. For livestock commodities, the residues of 

concern are the parent compound as well as the metabolites TZU, TZG, TZNG, ATMGpyruvate, and ATG-acetate. Milk is currently the only livestock-derived commodity with a 

tolerance for clothianidin. A factor of 1.5, which is based on metabolism data, has been 

incorporated into the assessment to account for the residues of concern in milk.

There are a number of crops for which uses of both clothianidin and thiamethoxam have been 

registered. The labels for the various end-use products containing these active ingredients 

prohibit the application of both active ingredients to the same crop during a growing cycle. Due 

to that restriction and the assumption of 100% crop treated, a single value reflecting the greatest 

clothianidin residue from either active ingredient has been used for crops listed for use with both 

active ingredients (versus combined estimates from clothianidin and from thiamethoxam). 

Generally, this assessment uses the established or recommended clothianidin tolerance for crops 

having tolerances for both compounds. For foods with thiamethoxam tolerances but without 

clothianidin tolerances, maximum residues of clothianidin observed in thiamethoxam residue

trials have been used in these assessments. These include meats, meat by-products, artichoke, 

tropical fruits, coffee, hop, and mint.

Orange processing study data show that clothianidin does not concentrate in citrus oil or juice. 

Relative to the whole fruit, there is a modest increase in residues in pulp (1.8X). These empirical 

processing factors, as well as those derived previously, have been included in these analyses. 

Complete listings of the residue estimates, metabolite factors, and processing factors used in 

these analyses may be found in Attachment 1.

The USDA’s Pesticide Data Program included clothianidin as a target analyte in its 2008-2010 

survey of pesticide residues in catfish. Over the course of those three years, there were no 

detectable residues of clothianidin in any of the 1479 samples of catfish. While there is no 

specific expectation of clothianidin residues in fish as a result of the compound’s agricultural 

uses, there is a use in food handling establishments; therefore, fish have been included as a 

source of clothianidin exposure in these analyses.

Table 1. Summary of Recommended Tolerance Levels for the Proposed New Uses and Label Amendments for 

Clothianidin.

Commodity Recommended 

Tolerance, ppm

Comments

Pistachio 0.01 Translated from existing tree nut listing

Strawberry 1.50 From acceptable field trial data

Fruit, citrus, group 10-10 0.60 From acceptable field trial data

Tea, fresh 70 From acceptable field trial data

Vegetables, fruiting, group 8-10, except 

pepper/eggplant subgroup 8-10B

0.20 From existing Group 8 listing

Vegetables, fruiting, pepper/eggplant subgroup 8-10B 0.80 From acceptable field trial data

III. Percent Crop Treated Information

HED has assumed 100% crop treated for these analyses.
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

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IV. Drinking Water Data

The Environmental Fate and Effects Division (EFED) has supplied HED with Tier I estimated 

drinking water concentrations (EDWC) for clothianidin in surface water resulting from foliar 

application to rice (R. Baris, 15 September 2011, D393235). 

EFED used the Tier I Rice Model (v 1.0) as a screening model to calculate the surface water 

EDWC resulting from a single foliar application of clothianidin to a flooded field (as proposed 

on the label). This concentration represents the estimated concentration that would be expected 

in the release water downstream of the treated rice paddy. FIRST (FQPA Index Reservoir 

Screening Tool, version 1.1, 01/01/07) was used to calculate the surface water EDWC resulting 

from a single foliar application to leafy vegetables. These concentrations are presented in Table 

2.

Table 2. Tier I EDWCs for drinking water risk assessment based on the proposed clothianidin use on rice and 

leafy vegetables

Use (application rate, lbs a.i./A) Model Acute Chronic

Surface water drinking water sources, 

downstream of rice paddy (0.084 lb a.i./A)

Tier I Rice Model 

(v1.0) 72 ppb <72 ppb

The EDWC of 72 ppb has been used to account for residues of clothianidin in both the acute and 

chronic dietary risk assessments. This is the same EDWC that was used in the most recent 

dietary assessment. EFED has confirmed that it is the appropriate value to use in this assessment 

(e-mail from R. Baris; 16 July 2012, 3:12:46 pm).

V. DEEM-FCID Program and Consumption Information

Clothianidin acute and chronic dietary exposure assessments were conducted using the Dietary

Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID, 

Version 3.16, which incorporates consumption data from USDA’s NHANES/WWEIA. This 

dietary survey was conducted from 2003 to 2008. The data are based on the reported 

consumption of more than 20,000 individuals over two non-consecutive survey days. Foods “as 

consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled 

fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly 

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic 

exposure assessment, consumption data are averaged for the entire U.S. population and within 

population subgroups. However, for acute exposure assessment, consumption data are retained 

as individual consumption events. Based on analysis of the 2003-2008 WWEIA consumption 

data, which took into account dietary patterns and survey respondents, HED concluded that it is 

most appropriate to report risk for the following population subgroups: the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

adults 20-49, females 13-49, and adults 50+ years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

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estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.

VI. Toxicological Information

The doses and endpoints for human health dietary risk assessments are summarized in Table 3.

Table 3. Clothianidin Toxicological Doses and Endpoints for Use in Human Health Dietary Risk Assessments

Exposure/

Scenario

Point of 

Departure

Uncertainty/ 

FQPA Safety 

Factors

Level of 

Concern for Risk 

Assessment

Study and Toxicological Effects

Acute Dietary

Females age 

13-49

NOAEL = 

25 mg/kg/day

UFA = 10x

UFH = 10x

SFFQPA =1

aRfD =

0.25 mg/kg/day

aPAD =

0.25 mg/kg/day

Rabbit developmental study 

LOAEL = 75 mg/kg/day based on increased 

litter incidence of a missing lobe of the lung

Acute Dietary

General 

population

NOAEL = 

25

mg/kg/day

UFA = 10x

UFH = 10x

SFFQPA = 1

aRfD =

0.25 mg/kg/day

aPAD =

0.25 mg/kg/day

Special neurotoxicity/pharmacol

study in mice 

LOAEL = 50 mg/kg/day based on transient 

signs of decreased spontaneous motor activity, 

tremors and deep respirations

Chronic Dietary

All populations

including 

infants and 

children

NOAEL= 

9.8 mg/kg/day 

UFA = 10x

UFH = 10x

SFFQPA =1

cRfD=0.098 

mg/kg/day

cPAD=0.098 

mg/kg/day

2-Generation reproduction study 

LOAEL = 31.2 mg/kg/day based on decreased 

body weight gains and delayed sexual 

maturation, decreased absolute thymus weights 

in F1 pups and increased stillbirths in both 

generations

Cancer “Not Likely to be Carcinogenic to Humans” 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in 

sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = 

population-adjusted dose (a = acute, c = chronic). RfD = reference dose.
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

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VII. Results/Discussion 

For acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the 

PAD. The DEEM-FCID analyses estimate the dietary exposure of the U.S. population and 

various population subgroups. The results reported in Table 4 are for the general U.S. 

Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50-99 years. All estimates are below HED’s level of 

concern.

Table 4. Summary of Acute and Chronic Dietary Exposure and Risk Estimates for Clothianidin.

Population Subgroup Acute (95th Percentile) Chronic

Exposure, mg/kg/day % aPAD Exposure, mg/kg/day % cPAD

Total US Population 0.020913 8 0.007458 8

All Infants 0.051461 21 0.016683 17

Children 1-2 years old 0.069586 28 0.027256 28

Children 3-5 years old 0.048260 19 0.018444 19

Children 6-12 years old 0.024264 10 0.009165 9

Youth 13-19 years old 0.014341 6 0.005346 6

Adults 20-49 years old 0.015090 6 0.005822 6

Adults 50-99 years old 0.014403 6 0.006109 6

Female 13-49 years old 0.015390 6 0.005974 6

The population subgroup(s) with the highest exposure/risk estimates are shown in bold.

VIII. Characterization of Inputs/Outputs

The acute and chronic assessments are based on highly conservative, health-protective 

assumptions regarding residue levels in food and percentage of crops treated. Likewise, the 

estimated concentration in drinking water is highly conservative, especially given that it 

represents residues in rice paddy tail water and no adjustment was made to take into account the 

portion of the watershed that would be cropped to rice. The analyses resulting from these 

assumptions should be considered screening-level analyses that likely overestimate actual dietary

exposure to clothianidin.

IX. Conclusions

There are no dietary exposure or risk considerations that would preclude making the label 

amendment shortening the PHI for Crop Subgroup 8-10B, registering the clothianidin end-use 

products as requested, and establishing tolerances commensurate with those registration actions.

X. List of Attachments

1. Inputs for the Acute and Chronic Dietary Exposure Assessment of Clothianidin.

2. Summary of the Results of the Acute Dietary Exposure Assessment of Clothianidin.

3. Summary of the Results of the Chronic Dietary Exposure Assessment of Clothianidin.
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

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Attachment 1. Inputs for the Acute and Chronic Dietary Exposure Assessment of Clothianidin.

Filename: C:\Documents and Settings\mdoherty\My Documents\Chemistry Reviews\!DEEM 

Runs\Clothianidin\2012\044309 (2012).R08

Chemical: Clothianidin

RfD(Chronic): .098 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 09-18-2012/10:16:01 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

9500001000 O Acerola 0.005000 1.000 1.000 From FHE Thiamethoxam

9500006000 O Amaranth, grain 0.005000 1.000 1.000 From FHE Thiamethoxam

9500016000 O Artichoke, globe 0.029000 1.000 1.000 From thiamethoxam

9500019000 O Asparagus 0.005000 1.000 1.000 From FHE Thiamethoxam

9500020000 O Avocado 0.020000 1.000 1.000 From thiamethoxam

9500022000 O Bamboo, shoots 0.005000 1.000 1.000 From FHE Thiamethoxam

9500023000 O Banana 0.005000 1.000 1.000 From FHE Thiamethoxam

9500024000 O Banana, dried 0.005000 3.900 1.000 From FHE Thiamethoxam

9500024001 O Banana, dried-babyfood 0.005000 3.900 1.000 From FHE Thiamethoxam

9500023001 O Banana-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

9500054000 O Belgium endive 0.005000 1.000 1.000 From FHE Thiamethoxam

9500060000 O Breadfruit 0.005000 1.000 1.000 From FHE Thiamethoxam

9500073000 O Cactus 0.005000 1.000 1.000 From FHE Thiamethoxam

9500074000 O Canistel 0.005000 1.000 1.000 From FHE Thiamethoxam

9500077000 O Carob 0.005000 1.000 1.000 From FHE Thiamethoxam

9500089000 O Cherimoya 0.005000 1.000 1.000 From FHE Thiamethoxam

9500109000 O Cocoa bean, chocolate 0.005000 1.000 1.000 From FHE Thiamethoxam

9500110000 O Cocoa bean, powder 0.005000 1.000 1.000 From FHE Thiamethoxam

9500112000 O Coconut, dried 0.005000 2.100 1.000 From FHE Thiamethoxam

9500111000 O Coconut, meat 0.005000 1.000 1.000 From FHE Thiamethoxam

9500111001 O Coconut, meat-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

9500113000 O Coconut, milk 0.005000 1.000 1.000 From FHE Thiamethoxam

9500114000 O Coconut, oil 0.005000 1.000 1.000 From FHE Thiamethoxam

9500116000 O Coffee, instant 0.040000 1.000 1.000 From thiamethoxam

9500115000 O Coffee, roasted bean 0.040000 1.000 1.000 From thiamethoxam

9500141000 O Date 0.005000 1.000 1.000 From FHE Thiamethoxam

9500151000 O Feijoa 0.005000 1.000 1.000 From FHE Thiamethoxam

9500153000 O Fig 0.050000 1.000 1.000 

9500154000 O Fig, dried 0.050000 1.000 1.000 

9500177000 O Grape, leaves 0.600000 1.000 1.000 

9500178000 O Grape, raisin 0.600000 2.500 1.000 

9500183000 O Guava 0.005000 1.000 1.000 From FHE Thiamethoxam

9500183001 O Guava-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

9500186000 O Honey 0.005000 1.000 1.000 From FHE Thiamethoxam

9500186001 O Honey-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

9500188000 O Hop 0.028000 1.000 1.000 From thiamethoxam

9500193000 O Jackfruit 0.005000 1.000 1.000 From FHE Thiamethoxam

9500209000 O Longan 0.005000 1.000 1.000 From FHE Thiamethoxam

9500211000 O Lychee 0.005000 1.000 1.000 From FHE Thiamethoxam

9500212000 O Lychee, dried 0.005000 1.850 1.000 From FHE Thiamethoxam

9500214000 O Mamey apple 0.005000 1.000 1.000 From FHE Thiamethoxam

9500215000 O Mango 0.020000 1.000 1.000 From thiamethoxam

9500216000 O Mango, dried 0.020000 1.000 1.000 From thiamethoxam

9500217000 O Mango, juice 0.020000 1.000 1.000 From thiamethoxam

9500217001 O Mango, juice-babyfood 0.020000 1.000 1.000 From thiamethoxam

9500215001 O Mango-babyfood 0.020000 1.000 1.000 From thiamethoxam

9500219000 O Maple syrup 0.005000 1.000 1.000 From FHE Thiamethoxam

9500218000 O Maple, sugar 0.005000 1.000 1.000 From FHE Thiamethoxam

9500235000 O Olive 0.005000 1.000 1.000 From FHE Thiamethoxam

9500236000 O Olive, oil 0.005000 1.000 1.000 From FHE Thiamethoxam

9500243000 O Palm heart, leaves 0.005000 1.000 1.000 From FHE Thiamethoxam

9500244000 O Palm, oil 0.005000 1.000 1.000 From FHE Thiamethoxam

9500244001 O Palm, oil-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

9500245000 O Papaya 0.020000 1.000 1.000 From thiamethoxam

9500246000 O Papaya, dried 0.020000 1.800 1.000 From thiamethoxam

9500247000 O Papaya, juice 0.020000 1.500 1.000 From thiamethoxam

9500245001 O Papaya-babyfood 0.020000 1.000 1.000 From thiamethoxam

9500252000 O Passionfruit 0.005000 1.000 1.000 From FHE Thiamethoxam
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

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9500253000 O Passionfruit, juice 0.005000 1.000 1.000 From FHE Thiamethoxam

9500253001 O Passionfruit, juice-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

9500252001 O Passionfruit-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

9500254000 O Pawpaw 0.005000 1.000 1.000 From FHE Thiamethoxam

9500263000 O Peanut 0.010000 1.000 1.000 

9500264000 O Peanut, butter 0.010000 1.890 1.000 

9500265000 O Peanut, oil 0.010000 0.310 1.000 PF for thiamethoxam

9500275000 O Peppermint 0.128000 1.000 1.000 From thiamethoxam

9500276000 O Peppermint, oil 0.128000 1.000 1.000 From thiamethoxam

9500277000 O Persimmon 0.005000 1.000 1.000 From FHE Thiamethoxam

9500279000 O Pineapple 0.005000 1.000 1.000 From FHE Thiamethoxam

9500280000 O Pineapple, dried 0.005000 5.000 1.000 From FHE Thiamethoxam

9500281000 O Pineapple, juice 0.005000 1.700 1.000 From FHE Thiamethoxam

9500281001 O Pineapple, juice-babyfood 0.005000 1.700 1.000 From FHE Thiamethoxam

9500279001 O Pineapple-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

9500283000 O Plantain 0.005000 1.000 1.000 From FHE Thiamethoxam

9500284000 O Plantain, dried 0.005000 3.900 1.000 From FHE Thiamethoxam

9500289000 O Pomegranate 0.200000 1.000 1.000 From thiamethoxam

9500306000 O Psyllium, seed 0.005000 1.000 1.000 From FHE Thiamethoxam

9500311000 O Quinoa, grain 0.005000 1.000 1.000 From FHE Thiamethoxam

9500333000 O Sapote, Mamey 0.020000 1.000 1.000 From thiamethoxam

9500335000 O Seaweed 0.005000 1.000 1.000 From FHE Thiamethoxam

9500335001 O Seaweed-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

9500346000 O Soursop 0.005000 1.000 1.000 From FHE Thiamethoxam

9500351000 O Spanish lime 0.005000 1.000 1.000 From FHE Thiamethoxam

9500352000 O Spearmint 0.128000 1.000 1.000 From thiamethoxam

9500353000 O Spearmint, oil 0.128000 1.000 1.000 From thiamethoxam

9500358000 O Starfruit 0.005000 1.000 1.000 From FHE Thiamethoxam

9500361000 O Sugar apple 0.005000 1.000 1.000 From FHE Thiamethoxam

9500363000 O Sugarcane, molasses 0.005000 1.000 1.000 From FHE Thiamethoxam

9500363001 O Sugarcane, molasses-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

9500362000 O Sugarcane, sugar 0.005000 1.000 1.000 From FHE Thiamethoxam

9500362001 O Sugarcane, sugar-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

9500368000 O Tamarind 0.005000 1.000 1.000 From FHE Thiamethoxam

9500372000 O Tea, dried 70.000000 1.000 1.000 1E7923 (2012)

9500373000 O Tea, instant 70.000000 1.000 1.000 1E7923 (2012)

9500390000 O Vinegar 0.005000 1.000 1.000 From FHE Thiamethoxam

9500397000 O Water chestnut 0.005000 1.000 1.000 From FHE Thiamethoxam

9500398000 O Watercress 0.005000 1.000 1.000 From FHE Thiamethoxam

0103015000 1CD Arrowroot, flour 0.300000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.300000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.300000 1.000 1.000 

0101050000 1AB Beet, garden, roots 0.800000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 0.800000 1.000 1.000 

0101052000 1A Beet, sugar 0.020000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 0.050000 1.000 1.000 

0101053001 1A Beet, sugar, molasses-babyfood 0.050000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.020000 1.000 1.000 

0101067000 1AB Burdock 0.800000 1.000 1.000 

0101078000 1AB Carrot 0.800000 1.000 1.000 

0101079000 1AB Carrot, juice 0.800000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.800000 1.000 1.000 

0103082000 1CD Cassava 0.300000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.300000 1.000 1.000 

0101084000 1AB Celeriac 0.800000 1.000 1.000 

0101100000 1AB Chicory, roots 0.800000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.300000 1.000 1.000 

0103166000 1CD Ginger 0.300000 1.000 1.000 

0103167000 1CD Ginger, dried 0.300000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.300000 1.000 1.000 

0101168000 1AB Ginseng, dried 0.800000 1.000 1.000 

0101190000 1AB Horseradish 0.800000 1.000 1.000 

0101250000 1AB Parsley, turnip rooted 0.800000 1.000 1.000 

0101251000 1AB Parsnip 0.800000 1.000 1.000 

0101251001 1AB Parsnip-babyfood 0.800000 1.000 1.000 

0103296000 1C Potato, chips 0.600000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 1.500000 6.500 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 1.500000 6.500 1.000 

0103298000 1C Potato, flour 0.300000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 0.300000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.300000 1.000 1.000 
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 9 of 17

0103300001 1C Potato, tuber, w/o peel-babyfood 0.300000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 0.300000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.300000 1.000 1.000 

0101316000 1AB Radish, Oriental, roots 0.800000 1.000 1.000 

0101314000 1AB Radish, roots 0.800000 1.000 1.000 

0101327000 1AB Rutabaga 0.800000 1.000 1.000 

0101331000 1AB Salsify, roots 0.800000 1.000 1.000 

0103366000 1CD Sweet potato 0.300000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.300000 1.000 1.000 

0103371000 1CD Tanier, corm 0.300000 1.000 1.000 

0103387000 1CD Turmeric 0.300000 1.000 1.000 

0101388000 1AB Turnip, roots 0.800000 1.000 1.000 

0103407000 1CD Yam bean 0.300000 1.000 1.000 

0103406000 1CD Yam, true 0.300000 1.000 1.000 

0200051000 2 Beet, garden, tops 0.600000 1.000 1.000 

0200101000 2 Chicory, tops 0.600000 1.000 1.000 

0200140000 2 Dasheen, leaves 0.600000 1.000 1.000 

0200317000 2 Radish, Oriental, tops 0.600000 1.000 1.000 

0200315000 2 Radish, tops 0.600000 1.000 1.000 

0200332000 2 Salsify, tops 0.600000 1.000 1.000 

0302103000 3B Chive, fresh leaves 0.005000 1.000 1.000 From FHE Thiamethoxam

0301165000 3A Garlic, bulb 0.450000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.450000 1.000 1.000 

0302198000 3B Leek 0.450000 1.000 1.000 

0301237000 3A Onion, bulb 0.450000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.450000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.450000 9.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.450000 1.000 1.000 

0302239000 3B Onion, green 0.450000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 0.450000 1.000 1.000 

0401005000 4A Amaranth, leafy 3.000000 1.100 1.000 1.1 factor to 

account for TMG metabolite

0401018000 4A Arugula 3.000000 1.100 1.000 1.1 factor to 

account for TMG metabolite

0402076000 4B Cardoon 0.400000 1.000 1.000 From Thiamethoxam

0402085000 4B Celery 0.400000 1.000 1.000 From Thiamethoxam

0402086000 4B Celery, juice 0.400000 1.000 1.000 From Thiamethoxam

0402085001 4B Celery-babyfood 0.400000 1.000 1.000 From Thiamethoxam

0402087000 4B Celtuce 0.400000 1.000 1.000 From Thiamethoxam

0401104000 4A Chrysanthemum, garland 3.000000 1.100 1.000 1.1 factor to 

account for TMG metabolite

0401133000 4A Cress, garden 3.000000 1.100 1.000 1.1 factor to 

account for TMG metabolite

0401134000 4A Cress, upland 3.000000 1.100 1.000 1.1 factor to 

account for TMG metabolite

0401138000 4A Dandelion, leaves 3.000000 1.100 1.000 1.1 factor to 

account for TMG metabolite

0401150000 4A Endive 3.000000 1.100 1.000 1.1 factor to 

account for TMG metabolite

0402152000 4B Fennel, Florence 0.400000 1.000 1.000 From Thiamethoxam

0401204000 4A Lettuce, head 3.000000 1.100 1.000 1.1 factor to 

account for TMG metabolite

0401205000 4A Lettuce, leaf 3.000000 1.100 1.000 1.1 factor to 

account for TMG metabolite

0401248000 4A Parsley, leaves 3.000000 1.100 1.000 1.1 factor to 

account for TMG metabolite

0401313000 4A Radicchio 3.000000 1.100 1.000 1.1 factor to 

account for TMG metabolite

0402322000 4B Rhubarb 0.400000 1.000 1.000 From Thiamethoxam

0401355000 4A Spinach 3.000000 1.100 1.000 1.1 factor to 

account for TMG metabolite

0401355001 4A Spinach-babyfood 3.000000 1.100 1.000 1.1 factor to 

account for TMG metabolite

0402367000 4B Swiss chard 0.400000 1.000 1.000 From Thiamethoxam

0501061000 5A Broccoli 1.900000 1.000 1.000 

0502063000 5B Broccoli raab 1.900000 1.000 1.000 

0501062000 5A Broccoli, Chinese 1.900000 1.000 1.000 

0501061001 5A Broccoli-babyfood 1.900000 1.000 1.000 

0501064000 5A Brussels sprouts 1.900000 1.000 1.000 

0501069000 5A Cabbage 1.900000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 1.900000 1.000 1.000 
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 10 of 17

0501072000 5A Cabbage, Chinese, mustard 1.900000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 1.900000 1.000 1.000 

0501083000 5A Cauliflower 1.900000 1.000 1.000 

0502117000 5B Collards 1.900000 1.000 1.000 

0502194000 5B Kale 1.900000 1.000 1.000 

0501196000 5A Kohlrabi 1.900000 1.000 1.000 

0502229000 5B Mustard greens 1.900000 1.000 1.000 

0502318000 5B Rape greens 1.900000 1.000 1.000 

0502389000 5B Turnip, greens 1.900000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.010000 1.000 1.000 From Thiamethoxam

0603030000 6C Bean, black, seed 0.010000 1.000 1.000 From Thiamethoxam

0603032000 6C Bean, broad, seed 0.010000 1.000 1.000 From Thiamethoxam

0602031000 6B Bean, broad, succulent 0.010000 1.000 1.000 From Thiamethoxam

0603034000 6C Bean, cowpea, seed 0.010000 1.000 1.000 From Thiamethoxam

0602033000 6B Bean, cowpea, succulent 0.010000 1.000 1.000 From Thiamethoxam

0603036000 6C Bean, kidney, seed 0.010000 1.000 1.000 From Thiamethoxam

0603038000 6C Bean, lima, seed 0.010000 1.000 1.000 From Thiamethoxam

0602037000 6B Bean, lima, succulent 0.010000 1.000 1.000 From Thiamethoxam

0603039000 6C Bean, mung, seed 0.010000 1.000 1.000 From Thiamethoxam

0603040000 6C Bean, navy, seed 0.010000 1.000 1.000 From Thiamethoxam

0603041000 6C Bean, pink, seed 0.010000 1.000 1.000 From Thiamethoxam

0603042000 6C Bean, pinto, seed 0.010000 1.000 1.000 From Thiamethoxam

0601043000 6A Bean, snap, succulent 0.010000 1.000 1.000 From Thiamethoxam

0601043001 6A Bean, snap, succulent-babyfood 0.010000 1.000 1.000 From Thiamethoxam

0603099000 6C Chickpea, flour 0.010000 1.000 1.000 From Thiamethoxam

0603098000 6C Chickpea, seed 0.010000 1.000 1.000 From Thiamethoxam

0603098001 6C Chickpea, seed-babyfood 0.010000 1.000 1.000 From Thiamethoxam

0603182000 6C Guar, seed 0.010000 1.000 1.000 From Thiamethoxam

0603182001 6C Guar, seed-babyfood 0.010000 1.000 1.000 From Thiamethoxam

0603203000 6C Lentil, seed 0.010000 1.000 1.000 From Thiamethoxam

0603256000 6C Pea, dry 0.010000 1.000 1.000 From Thiamethoxam

0603256001 6C Pea, dry-babyfood 0.010000 1.000 1.000 From Thiamethoxam

0601257000 6A Pea, edible podded, succulent 0.010000 1.000 1.000 From Thiamethoxam

0603258000 6C Pea, pigeon, seed 0.010000 1.000 1.000 From Thiamethoxam

0602259000 6B Pea, pigeon, succulent 0.010000 1.000 1.000 From Thiamethoxam

0602255000 6B Pea, succulent 0.010000 1.000 1.000 From Thiamethoxam

0602255001 6B Pea, succulent-babyfood 0.010000 1.000 1.000 From Thiamethoxam

0603348000 6C Soybean, flour 0.020000 1.000 1.000 From Thiamethoxam

0603348001 6C Soybean, flour-babyfood 0.020000 1.000 1.000 From Thiamethoxam

0600350000 6 Soybean, oil 0.020000 1.000 1.000 From Thiamethoxam

0600350001 6 Soybean, oil-babyfood 0.020000 1.000 1.000 From Thiamethoxam

0600347000 6 Soybean, seed 0.020000 1.000 1.000 From Thiamethoxam

0600349000 6 Soybean, soy milk 0.020000 1.000 1.000 From Thiamethoxam

0600349001 6 Soybean, soy milk-babyfood or in 0.020000 1.000 1.000 From Thiamethoxam

0802148000 8BC Eggplant 0.800000 1.000 1.000 Incr. tol. due to PHI 

change

0802234000 8BC Okra 0.800000 1.000 1.000 Incr. tol. due to PHI 

change

0802270000 8B Pepper, bell 0.800000 1.000 1.000 Incr. tol. due to PHI 

change

0802271000 8B Pepper, bell, dried 0.800000 1.000 1.000 Incr. tol. due to PHI 

change

0802271001 8B Pepper, bell, dried-babyfood 0.800000 1.000 1.000 Incr. tol. due to PHI 

change

0802270001 8B Pepper, bell-babyfood 0.800000 1.000 1.000 Incr. tol. due to PHI 

change

0802272000 8BC Pepper, nonbell 0.800000 1.000 1.000 Incr. tol. due to PHI 

change

0802273000 8BC Pepper, nonbell, dried 0.800000 1.000 1.000 Incr. tol. due to PHI 

change

0802272001 8BC Pepper, nonbell-babyfood 0.800000 1.000 1.000 Incr. tol. due to PHI 

change

0801374000 8A Tomatillo 0.200000 1.000 1.000 

0801375000 8A Tomato 0.200000 1.000 1.000 

0801380000 8A Tomato, Tree 0.005000 1.000 1.000 From FHE Thiamethoxam

0801378000 8A Tomato, dried 0.200000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.200000 14.300 1.000 

0801379000 8A Tomato, juice 0.200000 1.500 1.000 

0801376000 8A Tomato, paste 0.200000 5.400 1.000 

0801376001 8A Tomato, paste-babyfood 0.200000 5.400 1.000 

0801377000 8A Tomato, puree 0.200000 3.300 1.000 
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 11 of 17

0801377001 8A Tomato, puree-babyfood 0.200000 3.300 1.000 

0801375001 8A Tomato-babyfood 0.200000 1.000 1.000 

0902021000 9B Balsam pear 0.060000 1.000 1.000 

0901075000 9A Cantaloupe 0.060000 1.000 1.000 

0902088000 9B Chayote, fruit 0.060000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.060000 1.000 1.000 

0902135000 9B Cucumber 0.060000 1.000 1.000 

0901187000 9A Honeydew melon 0.060000 1.000 1.000 

0902308000 9B Pumpkin 0.060000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.060000 1.000 1.000 

0902356000 9B Squash, summer 0.060000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.060000 1.000 1.000 

0902357000 9B Squash, winter 0.060000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.060000 1.000 1.000 

0901399000 9A Watermelon 0.060000 1.000 1.000 

0901400000 9A Watermelon, juice 0.060000 1.000 1.000 

1001106000 10A Citron 0.600000 1.000 1.000 1E7923 (2012)

1001107000 10A Citrus hybrids 0.600000 1.000 1.000 1E7923 (2012)

1001108000 10A Citrus, oil 0.600000 1.000 1.000 1E7923 (2012)

1003180000 10C Grapefruit 0.600000 1.000 1.000 1E7923 (2012)

1003181000 10C Grapefruit, juice 0.600000 1.000 1.000 1E7923 (2012)

1002197000 10B Kumquat 0.600000 1.000 1.000 1E7923 (2012)

1002199000 10B Lemon 0.600000 1.000 1.000 1E7923 (2012)

1002200000 10B Lemon, juice 0.600000 1.000 1.000 1E7923 (2012)

1002200001 10B Lemon, juice-babyfood 0.600000 1.000 1.000 1E7923 (2012)

1002201000 10B Lemon, peel 0.600000 1.000 1.000 1E7923 (2012)

1002206000 10B Lime 0.600000 1.000 1.000 1E7923 (2012)

1002207000 10B Lime, juice 0.600000 1.000 1.000 1E7923 (2012)

1002207001 10B Lime, juice-babyfood 0.600000 1.000 1.000 1E7923 (2012)

1001240000 10A Orange 0.600000 1.000 1.000 1E7923 (2012)

1001241000 10A Orange, juice 0.600000 1.000 1.000 1E7923 (2012)

1001241001 10A Orange, juice-babyfood 0.600000 1.000 1.000 1E7923 (2012)

1001242000 10A Orange, peel 0.600000 1.000 1.000 1E7923 (2012)

1003307000 10C Pummelo 0.600000 1.000 1.000 1E7923 (2012)

1001369000 10A Tangerine 0.600000 1.000 1.000 1E7923 (2012)

1001370000 10A Tangerine, juice 0.600000 1.000 1.000 1E7923 (2012)

1100009000 11 Apple, dried 1.000000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 1.000000 8.000 1.000 

1100007000 11 Apple, fruit with peel 1.000000 1.000 1.000 

1100010000 11 Apple, juice 1.000000 1.300 1.000 

1100010001 11 Apple, juice-babyfood 1.000000 1.300 1.000 

1100008000 11 Apple, peeled fruit 1.000000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 1.000000 1.000 1.000 

1100011000 11 Apple, sauce 1.000000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 1.000000 1.000 1.000 

1100129000 11 Crabapple 1.000000 1.000 1.000 

1100210000 11 Loquat 1.000000 1.000 1.000 

1100266000 11 Pear 1.000000 1.000 1.000 

1100267000 11 Pear, dried 1.000000 6.250 1.000 

1100268000 11 Pear, juice 1.000000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 1.000000 1.000 1.000 

1100266001 11 Pear-babyfood 1.000000 1.000 1.000 

1100310000 11 Quince 1.000000 1.000 1.000 

1202012000 12B Apricot 0.800000 1.000 1.000 Expected use on whole 

group

1202013000 12B Apricot, dried 0.800000 6.000 1.000 Expected use on whole 

group

1202014000 12B Apricot, juice 0.800000 1.000 1.000 Expected use on whole 

group

1202014001 12B Apricot, juice-babyfood 0.800000 1.000 1.000 Expected use on whole 

group

1202012001 12B Apricot-babyfood 0.800000 1.000 1.000 Expected use on whole 

group

1201090000 12A Cherry 0.800000 1.000 1.000 Expected use on whole 

group

1201091000 12A Cherry, juice 0.800000 1.500 1.000 Expected use on whole 

group

1201091001 12A Cherry, juice-babyfood 0.800000 1.500 1.000 Expected use on whole 

group

1201090001 12A Cherry-babyfood 0.800000 1.000 1.000 Expected use on whole 

group
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 12 of 17

1202230000 12B Nectarine 0.800000 1.000 1.000 Expected use on whole 

group

1202260000 12B Peach 0.800000 1.000 1.000 

1202261000 12B Peach, dried 0.800000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 0.800000 7.000 1.000 

1202262000 12B Peach, juice 0.800000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.800000 1.000 1.000 

1202260001 12B Peach-babyfood 0.800000 1.000 1.000 

1203285000 12C Plum 0.800000 1.000 1.000 Expected use on whole 

group

1203287000 12C Plum, prune, dried 0.800000 5.000 1.000 Expected use on whole 

group

1203287001 12C Plum, prune, dried-babyfood 0.800000 5.000 1.000 Expected use on whole 

group

1203286000 12C Plum, prune, fresh 0.800000 1.000 1.000 Expected use on whole 

group

1203286001 12C Plum, prune, fresh-babyfood 0.800000 1.000 1.000 Expected use on whole 

group

1203288000 12C Plum, prune, juice 0.800000 1.400 1.000 Expected use on whole 

group

1203288001 12C Plum, prune, juice-babyfood 0.800000 1.400 1.000 Expected use on whole 

group

1203285001 12C Plum-babyfood 0.800000 1.000 1.000 Expected use on whole 

group

1301055000 13A Blackberry 0.040000 1.000 1.000 From Thiamethoxam

1301056000 13A Blackberry, juice 0.040000 1.000 1.000 From Thiamethoxam

1301056001 13A Blackberry, juice-babyfood 0.040000 1.000 1.000 From Thiamethoxam

1302057000 13B Blueberry 0.050000 1.000 1.000 From Thiamethoxam

1302057001 13B Blueberry-babyfood 0.050000 1.000 1.000 From Thiamethoxam

1301058000 13A Boysenberry 0.040000 1.000 1.000 From Thiamethoxam

1307130000 13G Cranberry 0.010000 1.000 1.000 

1307131000 13G Cranberry, dried 0.010000 1.000 1.000 

1307132000 13G Cranberry, juice 0.010000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 0.010000 1.100 1.000 

1307130001 13G Cranberry-babyfood 0.010000 1.000 1.000 

1302136000 13B Currant 0.050000 1.000 1.000 From Thiamethoxam

1302137000 13B Currant, dried 0.050000 1.000 1.000 From Thiamethoxam

1302149000 13B Elderberry 0.050000 1.000 1.000 From Thiamethoxam

1302174000 13B Gooseberry 0.050000 1.000 1.000 From Thiamethoxam

1304175000 13D Grape 0.600000 1.000 1.000 

1304176000 13D Grape, juice 0.600000 1.200 1.000 

1304176001 13D Grape, juice-babyfood 0.600000 1.200 1.000 

1304179000 13D Grape, wine and sherry 0.600000 1.200 1.000 

1302191000 13B Huckleberry 0.050000 1.000 1.000 From Thiamethoxam

1304195000 13D Kiwifruit, fuzzy 0.005000 1.000 1.000 From FHE Thiamethoxam

1301208000 13A Loganberry 0.040000 1.000 1.000 From Thiamethoxam

1303227000 13C Mulberry 0.005000 1.000 1.000 From FHE Thiamethoxam

1301320000 13A Raspberry 0.040000 1.000 1.000 From Thiamethoxam

1301321000 13A Raspberry, juice 0.040000 1.000 1.000 From Thiamethoxam

1301321001 13A Raspberry, juice-babyfood 0.040000 1.000 1.000 From Thiamethoxam

1301320001 13A Raspberry-babyfood 0.040000 1.000 1.000 From Thiamethoxam

1307359000 13G Strawberry 1.500000 1.000 1.000 1E7923 (2012)

1307360000 13G Strawberry, juice 1.500000 1.000 1.000 1E7923 (2012)

1307360001 13G Strawberry, juice-babyfood 1.500000 1.000 1.000 1E7923 (2012)

1307359001 13G Strawberry-babyfood 1.500000 1.000 1.000 1E7923 (2012)

1400003000 14 Almond 0.010000 1.000 1.000 

1400004000 14 Almond, oil 0.010000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.010000 1.000 1.000 

1400003001 14 Almond-babyfood 0.010000 1.000 1.000 

1400059000 14 Brazil nut 0.010000 1.000 1.000 

1400068000 14 Butternut 0.010000 1.000 1.000 

1400081000 14 Cashew 0.010000 1.000 1.000 

1400092000 14 Chestnut 0.010000 1.000 1.000 

1400155000 14 Hazelnut 0.010000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.010000 1.000 1.000 

1400185000 14 Hickory nut 0.010000 1.000 1.000 

1400213000 14 Macadamia nut 0.010000 1.000 1.000 

1400269000 14 Pecan 0.010000 1.000 1.000 

1400278000 14 Pine nut 0.005000 1.000 1.000 From FHE Thiamethoxam

1400282000 14 Pistachio 0.010000 1.000 1.000 

1400391000 14 Walnut 0.010000 1.000 1.000 
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 13 of 17

1500027000 15 Barley, bran 0.020000 1.000 1.000 From thiamethoxam

1500026000 15 Barley, flour 0.020000 1.000 1.000 From thiamethoxam

1500026001 15 Barley, flour-babyfood 0.020000 1.000 1.000 From thiamethoxam

1500025000 15 Barley, pearled barley 0.020000 1.000 1.000 From thiamethoxam

1500025001 15 Barley, pearled barley-babyfood 0.020000 1.000 1.000 From thiamethoxam

1500065000 15 Buckwheat 0.010000 1.000 1.000 Grain seed treatment

1500066000 15 Buckwheat, flour 0.010000 1.000 1.000 Grain seed treatment

1500122000 15 Corn, field, bran 0.010000 1.000 1.000 

1500120000 15 Corn, field, flour 0.010000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.010000 1.000 1.000 

1500121000 15 Corn, field, meal 0.010000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.010000 1.000 1.000 

1500125000 15 Corn, field, oil 0.010000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.010000 1.000 1.000 

1500123000 15 Corn, field, starch 0.010000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.010000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.010000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.010000 1.500 1.000 

1500126000 15 Corn, pop 0.010000 1.000 1.000 

1500127000 15 Corn, sweet 0.010000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.010000 1.000 1.000 

1500226000 15 Millet, grain 0.010000 1.000 1.000 Grain seed treatment

1500231000 15 Oat, bran 0.010000 1.000 1.000 Grain seed treatment

1500232000 15 Oat, flour 0.010000 1.000 1.000 Grain seed treatment

1500232001 15 Oat, flour-babyfood 0.010000 1.000 1.000 Grain seed treatment

1500233000 15 Oat, groats/rolled oats 0.010000 1.000 1.000 Grain seed treatment

1500233001 15 Oat, groats/rolled oats-babyfood 0.010000 1.000 1.000 Grain seed treatment

1500326000 15 Rice, bran 0.010000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 0.010000 1.000 1.000 

1500324000 15 Rice, brown 0.010000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 0.010000 1.000 1.000 

1500325000 15 Rice, flour 0.010000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 0.010000 1.000 1.000 

1500323000 15 Rice, white 0.010000 1.000 1.000 

1500323001 15 Rice, white-babyfood 0.010000 1.000 1.000 

1500329000 15 Rye, flour 0.010000 1.000 1.000 Grain seed treatment

1500328000 15 Rye, grain 0.010000 1.000 1.000 Grain seed treatment

1500344000 15 Sorghum, grain 0.010000 1.000 1.000 

1500345000 15 Sorghum, syrup 0.010000 1.000 1.000 

1500381000 15 Triticale, flour 0.010000 1.000 1.000 Grain seed treatment

1500381001 15 Triticale, flour-babyfood 0.010000 1.000 1.000 Grain seed treatment

1500404000 15 Wheat, bran 0.010000 1.000 1.000 

1500402000 15 Wheat, flour 0.010000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.010000 1.000 1.000 

1500403000 15 Wheat, germ 0.010000 1.000 1.000 

1500401000 15 Wheat, grain 0.010000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.010000 1.000 1.000 

1500405000 15 Wild rice 0.010000 1.000 1.000 Grain seed treatment

1800002000 18 Alfalfa, seed 0.005000 1.000 1.000 From FHE Thiamethoxam

1901029000 19A Basil, dried leaves 0.005000 1.000 1.000 From FHE Thiamethoxam

1901029001 19A Basil, dried leaves-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

1901028000 19A Basil, fresh leaves 0.005000 1.000 1.000 From FHE Thiamethoxam

1901028001 19A Basil, fresh leaves-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

1901118000 19A Cilantro, leaves 0.005000 1.000 1.000 From FHE Thiamethoxam

1901118001 19A Cilantro, leaves-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

1902105000 19B Cinnamon 0.005000 1.000 1.000 From FHE Thiamethoxam

1902105001 19B Cinnamon-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

1902119000 19B Coriander, seed 0.005000 1.000 1.000 From FHE Thiamethoxam

1902119001 19B Coriander, seed-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

1902143000 19B Dill, seed 0.005000 1.000 1.000 From FHE Thiamethoxam

1901144000 19A Dillweed 0.005000 1.000 1.000 From FHE Thiamethoxam

1901184000 19A Herbs, other 0.005000 1.000 1.000 From FHE Thiamethoxam

1901184001 19A Herbs, other-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

1901202000 19A Lemongrass 0.005000 1.000 1.000 From FHE Thiamethoxam

1901220000 19A Marjoram 0.005000 1.000 1.000 From FHE Thiamethoxam

1901220001 19A Marjoram-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

1901249000 19A Parsley, dried leaves 0.005000 1.000 1.000 From FHE Thiamethoxam

1901249001 19A Parsley, dried leaves-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

1902274000 19B Pepper, black and white 0.005000 1.000 1.000 From FHE Thiamethoxam

1902274001 19B Pepper, black and white-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

1901334000 19A Savory 0.005000 1.000 1.000 From FHE Thiamethoxam
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 14 of 17

1902354000 19B Spices, other 0.005000 1.000 1.000 From FHE Thiamethoxam

1902354001 19B Spices, other-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

2003114001 20C Coconut, oil-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

2003128000 20C Cottonseed, oil 0.200000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.200000 1.000 1.000 

2001163000 20A Flax seed, oil 0.010000 1.000 1.000 

2001319000 20A Rapeseed, oil 0.010000 1.000 1.000 

2001319001 20A Rapeseed, oil-babyfood 0.010000 1.000 1.000 

2002330000 20B Safflower, oil 0.010000 1.000 1.000 

2002330001 20B Safflower, oil-babyfood 0.010000 1.000 1.000 

2001337000 20A Sesame, oil 0.005000 1.000 1.000 From FHE Thiamethoxam

2001337001 20A Sesame, oil-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

2001336000 20A Sesame, seed 0.005000 1.000 1.000 From FHE Thiamethoxam

2001336001 20A Sesame, seed-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

2002365000 20B Sunflower, oil 0.010000 1.000 1.000 

2002365001 20B Sunflower, oil-babyfood 0.010000 1.000 1.000 

2002364000 20B Sunflower, seed 0.010000 1.000 1.000 

2100228000 21 Mushroom 0.005000 1.000 1.000 From FHE Thiamethoxam

3100047000 31 Beef, fat 0.005000 1.000 1.000 From FHE Thiamethoxam

3100047001 31 Beef, fat-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

3100048000 31 Beef, kidney 0.010000 1.000 1.000 From thiamethoxam

3100049000 31 Beef, liver 0.010000 1.000 1.000 From thiamethoxam

3100049001 31 Beef, liver-babyfood 0.010000 1.000 1.000 From thiamethoxam

3100044000 31 Beef, meat 0.010000 1.000 1.000 From thiamethoxam

3100046000 31 Beef, meat byproducts 0.010000 1.000 1.000 From thiamethoxam

3100046001 31 Beef, meat byproducts-babyfood 0.010000 1.000 1.000 From thiamethoxam

3100045000 31 Beef, meat, dried 0.010000 1.920 1.000 From thiamethoxam

3100044001 31 Beef, meat-babyfood 0.010000 1.000 1.000 From thiamethoxam

3200171000 32 Goat, fat 0.005000 1.000 1.000 From FHE Thiamethoxam

3200172000 32 Goat, kidney 0.010000 1.000 1.000 From thiamethoxam

3200173000 32 Goat, liver 0.010000 1.000 1.000 From thiamethoxam

3200169000 32 Goat, meat 0.010000 1.000 1.000 From thiamethoxam

3200170000 32 Goat, meat byproducts 0.010000 1.000 1.000 From thiamethoxam

3300189000 33 Horse, meat 0.010000 1.000 1.000 From thiamethoxam

3400293000 34 Pork, fat 0.005000 1.000 1.000 From FHE Thiamethoxam

3400293001 34 Pork, fat-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

3400294000 34 Pork, kidney 0.010000 1.000 1.000 From thiamethoxam

3400295000 34 Pork, liver 0.010000 1.000 1.000 From thiamethoxam

3400290000 34 Pork, meat 0.010000 1.000 1.000 From thiamethoxam

3400292000 34 Pork, meat byproducts 0.010000 1.000 1.000 From thiamethoxam

3400292001 34 Pork, meat byproducts-babyfood 0.010000 1.000 1.000 From thiamethoxam

3400290001 34 Pork, meat-babyfood 0.010000 1.000 1.000 From thiamethoxam

3400291000 34 Pork, skin 0.005000 1.000 1.000 From FHE Thiamethoxam

3500341000 35 Sheep, fat 0.005000 1.000 1.000 From FHE Thiamethoxam

3500341001 35 Sheep, fat-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

3500342000 35 Sheep, kidney 0.010000 1.000 1.000 From thiamethoxam

3500343000 35 Sheep, liver 0.010000 1.000 1.000 From thiamethoxam

3500339000 35 Sheep, meat 0.010000 1.000 1.000 From thiamethoxam

3500340000 35 Sheep, meat byproducts 0.010000 1.000 1.000 From thiamethoxam

3500339001 35 Sheep, meat-babyfood 0.010000 1.000 1.000 From thiamethoxam

3600222000 36 Milk, fat 0.010000 1.500 1.000 1.5 factor to 

account for metabolites

3600222001 36 Milk, fat-baby food/infant formu 0.010000 1.500 1.000 1.5 factor to 

account for metabolites

3600223000 36 Milk, nonfat solids 0.010000 1.500 1.000 1.5 factor to 

account for metabolites

3600223001 36 Milk, nonfat solids-baby food/in 0.010000 1.500 1.000 1.5 factor to 

account for metabolites

3600225001 36 Milk, sugar (lactose)-baby food/ 0.010000 1.500 1.000 1.5 factor to 

account for metabolites

3600224000 36 Milk, water 0.010000 1.500 1.000 1.5 factor to 

account for metabolites

3600224001 36 Milk, water-babyfood/infant form 0.010000 1.500 1.000 1.5 factor to 

account for metabolites

3800221000 38 Meat, game 0.010000 1.000 1.000 From thiamethoxam

3900312000 39 Rabbit, meat 0.010000 1.000 1.000 From thiamethoxam

4000096000 40 Chicken, fat 0.005000 1.000 1.000 From FHE Thiamethoxam

4000096001 40 Chicken, fat-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

4000094000 40 Chicken, liver 0.005000 1.000 1.000 From FHE Thiamethoxam

4000093000 40 Chicken, meat 0.005000 1.000 1.000 From FHE Thiamethoxam

4000095000 40 Chicken, meat byproducts 0.005000 1.000 1.000 From FHE Thiamethoxam
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 15 of 17

4000095001 40 Chicken, meat byproducts-babyfoo 0.005000 1.000 1.000 From FHE Thiamethoxam

4000093001 40 Chicken, meat-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

4000097000 40 Chicken, skin 0.005000 1.000 1.000 From FHE Thiamethoxam

4000097001 40 Chicken, skin-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

5000385000 50 Turkey, fat 0.005000 1.000 1.000 From FHE Thiamethoxam

5000385001 50 Turkey, fat-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

5000383000 50 Turkey, liver 0.005000 1.000 1.000 From FHE Thiamethoxam

5000383001 50 Turkey, liver-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

5000382000 50 Turkey, meat 0.005000 1.000 1.000 From FHE Thiamethoxam

5000384000 50 Turkey, meat byproducts 0.005000 1.000 1.000 From FHE Thiamethoxam

5000384001 50 Turkey, meat byproducts-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

5000382001 50 Turkey, meat-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

5000386000 50 Turkey, skin 0.005000 1.000 1.000 From FHE Thiamethoxam

5000386001 50 Turkey, skin-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

6000304000 60 Poultry, other, fat 0.005000 1.000 1.000 From FHE Thiamethoxam

6000302000 60 Poultry, other, liver 0.005000 1.000 1.000 From FHE Thiamethoxam

6000301000 60 Poultry, other, meat 0.005000 1.000 1.000 From FHE Thiamethoxam

6000303000 60 Poultry, other, meat byproducts 0.005000 1.000 1.000 From FHE Thiamethoxam

6000305000 60 Poultry, other, skin 0.005000 1.000 1.000 From FHE Thiamethoxam

7000146000 70 Egg, white 0.005000 1.000 1.000 From FHE Thiamethoxam

7000146001 70 Egg, white (solids)-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

7000145000 70 Egg, whole 0.005000 1.000 1.000 From FHE Thiamethoxam

7000145001 70 Egg, whole-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

7000147000 70 Egg, yolk 0.005000 1.000 1.000 From FHE Thiamethoxam

7000147001 70 Egg, yolk-babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam

8000157000 80 Fish-freshwater finfish 0.005000 1.000 1.000 From FHE Thiamethoxam

8000158000 80 Fish-freshwater finfish, farm ra 0.005000 1.000 1.000 From FHE Thiamethoxam

8000160000 80 Fish-saltwater finfish, other 0.005000 1.000 1.000 From FHE Thiamethoxam

8000159000 80 Fish-saltwater finfish, tuna 0.005000 1.000 1.000 From FHE Thiamethoxam

8000161000 80 Fish-shellfish, crustacean 0.005000 1.000 1.000 From FHE Thiamethoxam

8000162000 80 Fish-shellfish, mollusc 0.005000 1.000 1.000 From FHE Thiamethoxam

8601000000 86A Water, direct, all sources 0.072000 1.000 1.000 Based on Rice Use

8602000000 86B Water, indirect, all sources 0.072000 1.000 1.000 Based on Rice Use
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 16 of 17

Attachment 2. Summary of the Results of the Acute Dietary Exposure Assessment of 

Clothianidin.

Health Effects Division OPP EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for CLOTHIANIDIN NHANES 2003-2008 2-Day

Residue file: 044309 (2012).R08 Adjustment factor #2 NOT used.

Analysis Date: 09-27-2012/10:31:30 Residue file dated: 09-27-2012/10:29:09

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.020913 8.37 0.042688 17.08 0.090403 36.16 

All Infants:

 0.051461 20.58 0.083284 33.31 0.148482 59.39 

Children 1-2:

 0.069586 27.83 0.112708 45.08 0.191457 76.58 

Children 3-5:

 0.048260 19.30 0.071642 28.66 0.108357 43.34 

Children 6-12:

 0.024264 9.71 0.039843 15.94 0.071398 28.56 

Youth 13-19:

 0.014341 5.74 0.021983 8.79 0.038829 15.53 

Adults 20-49:

 0.015090 6.04 0.022554 9.02 0.035057 14.02 

Adults 50-99:

 0.014403 5.76 0.020962 8.38 0.029246 11.70 

Female 13-49:

 0.015390 6.16 0.022581 9.03 0.035021 14.01 
Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 17 of 17

Attachment 3. Summary of the Results of the Chronic Dietary Exposure Assessment of 

Clothianidin.

Health Effects Division OPP EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for CLOTHIANIDIN NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\mdoherty\My Documents\Chemistry Reviews\!DEEM 

Runs\Clothianidin\2012\044309 (2012).R08

 Adjustment factor #2 NOT used.

Analysis Date 09-27-2012/10:30:23 Residue file dated: 09-27-2012/10:29:09

Reference dose (RfD, Chronic) = .098 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.007458 7.6%

Hispanic 0.008116 8.3%

Non-Hisp-White 0.007316 7.5%

Non-Hisp-Black 0.007063 7.2%

Non-Hisp-Other 0.008579 8.8%

Nursing Infants 0.009356 9.5%

Non-Nursing Infants 0.019955 20.4%

Female 13+ PREG 0.006687 6.8%

Children 1-6 0.020830 21.3%

Children 7-12 0.008313 8.5%

Male 13-19 0.005242 5.3%

Female 13-19/NP 0.005442 5.6%

Male 20+ 0.005572 5.7%

Female 20+/NP 0.006255 6.4%

Seniors 55+ 0.006109 6.2%

All Infants 0.016683 17.0%

Female 13-50 0.005986 6.1%

Children 1-2 0.027256 27.8%

Children 3-5 0.018444 18.8%

Children 6-12 0.009165 9.4%

Youth 13-19 0.005346 5.5%

Adults 20-49 0.005822 5.9%

Adults 50-99 0.006109 6.2%

Female 13-49 0.005974 6.1%

-------------------------------------------------------------------------------