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|   | [  ] | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|--------|----------------|-----------------------------------------------------------------------------------------------|

|   | Delaware(State or other jurisdictionof incorporation or organization) |   | 59-2058100(I.R.S.  EmployerIdentification No.) |   |
|--------|-----------------------------------------------------------------------|--------|----------------------------------------------------------|--------|

|   |  Title of each classNone |   | Name of each exchangeon which registeredNone |   |
|--------|-------------------------------|--------|----------------------------------------------|--------|

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|   | Large accelerated filer [__] | Accelerated filer [__]        |   |
|--------|------------------------------|-------------------------------|--------|
|   |                         |                          |   |
|   | Non-accelerated filer [__]   | Smaller reporting company [X] |   |

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|   | (b) | Exhibits |
|--------|-----|----------|

| 2.1        | Agreement and Plan of Merger, dated September 25, 2002, between PhotoMedex, Inc., J Merger Corp., Inc. and Surgical Laser Technologies, Inc. (1)                                                              |
|------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 2.2        | Agreement and Plan of Merger, dated December 1, 2004, between PhotoMedex, Inc., Gold Acquisition Merger Corp. and ProCyte Corporation (2)                                                                     |
| 2.3        | Securities Purchase Agreement, dated October 31, 2006, by and between PhotoMedex, Inc. and each purchaser a party thereto (3)                                                                                 |
| 2.4        | Purchase Agreement, dated August 4, 2008, by and among PhotoMedex, Inc., Photo Therapeutics Group Limited and Neil Crabb. (21)                                                                                |
| 2.5        | Asset Purchase Agreement, dated August 1, 2008, by and between PhotoMedex, Inc. and PRI Medical Technologies, Inc. (21)                                                                                       |
| 2.6        | Form of Securities Purchase Agreement, dated October 22, 2009, between PhotoMedex, Inc. and each Purchaser (29)                                                                                          |
| 3.1        | Restated Certificate of Incorporation, filed on August 8, 2000 (4)                                                                                                                                            |
| 3.2        | Amendment to Restated Certificate of Incorporation, filed on January 6, 2004 (22)                                                                                                                             |
| 3.3        | Amendment to Restated Certificate of Incorporation, filed on January 26, 2009. (26)                                                                                                                           |
| 3.4        | Amended and Restated Certificate of Incorporation, filed on February 3, 2010 (32)                                                                                                                             |
| 3.5        | Amended and Restated Bylaws (5)                                                                                                                                                                               |
| 3.6        | Amended Section 6.01 of the By-Laws, October 30, 2007 (19)                                                                                                                                                    |
| 4.1        | Securities Purchase Agreement, dated August 4, 2008, by and between PhotoMedex, Inc. and Perseus Partners VII, LP, including Form of Convertible Note, Form of Warrant and Registration Rights Agreement (21) |
| 4.2        | Amendment No. 1 to Securities Purchase Agreement, dated February 27, 2009. (24)                                                                                                                               |
| 4.3        | First Tranche Convertible Promissory Note, dated February 27, 2009. (24)                                                                                                                                      |
| 4.4        | Pledge and Security Agreement, dated February 27, 2009. (24)                                                                                                                                                  |
| 4.5        | First Tranche Warrant, dated February 27, 2009. (24)                                                                                                                                                          |
| 4.6        | Registration Rights Agreement, dated February 27, 2009 (26)                                                                                                                                                   |
| 4.7        | PhotoMedex Inc. Secured Convertible Promissory Note, dated September 1, 2009 (30)                                                                                                                        |
| 10.1       | Lease Agreement dated May 29, 1996, between Surgical Laser Technologies, Inc. and Nappen & Associates (Montgomeryville, Pennsylvania) (5)                                                                 |
| 10.2       | Lease Renewal Agreement, dated January 18, 2001, between Surgical Laser Technologies, Inc. and Nappen & Associates (5)                                                                                    |
| 10.3       | Lease Agreement, dated July 10, 2006, PhotoMedex, Inc. and Nappen & Associates (6)                                                                                                                        |
| 10.4       | Standard Industrial/Commercial Multi-Tenant Lease - Net, dated July 30, 2008 (additional facility at Carlsbad, California)(26)                                                                                |
| 10.5       | Standard Industrial/Commercial Multi-Tenant Lease  Net, dated March 17, 2005 (Carlsbad, California)(8)                                                                                              |
| 10.6       | Industrial Real Estate Lease, dated May 3, 2007, and delivered December 14, 2007 (26)                                                                                                                         |
|  10.7 | License and Development Agreement, dated May 22, 2002, between Surgical Laser Technologies, Inc. and Reliant Technologies, Inc. (5)                                                                           |
| 10.8       | Settlement Agreement and Release, dated November 11, 2008, by and among Allergan, Inc., Murray A. Johnstone, MD, PhotoMedex, Inc. and ProCyte Corporation. (26)                                               |
| 10.9       | Master Purchase Agreement, dated September 7, 2004, between PhotoMedex, Inc. and Stern Laser, srl (9)                                                                                                         |
| 10.10      | Master Lease Agreement, dated June 25, 2004, between PhotoMedex, Inc. and GE Capital Corporation. (10)                                                                                                        |
| 10.11      | Investment Agreement, dated March 30, 2006, between AzurTec, Inc. and PhotoMedex, Inc. (11)                                                                                                                   |
| 10.12      | License Agreement, dated March 30, 3006, between AzurTec, Inc. and PhotoMedex, Inc. (11)                                                                                                                      |
| 10.13      | License Agreement, dated March 31, 2006, and effective April 1, 1006, between the Mount Sinai School of Medicine and PhotoMedex, Inc. (12)                                                                    |
| 10.14      | 2005 Equity Compensation Plan, approved December 28, 2005 (13)                                                                                                                                                |
| 10.15      | 2005 Investment Plan, approved December 28, 2005 (13)                                                                                                                                                         |
| 10.16      | Amended and Restated 2000 Non-Employee Director Stock Option Plan (1)                                                                                                                                         |
| 10.17      | Amended and Restated 2000 Stock Option Plan (1)                                                                                                                                                               |
| 10.18      | 2004 Stock Option Plan, assumed from ProCyte (14)                                                                                                                                                             |
| 10.19      | 1996 Stock Option Plan, assumed from ProCyte (14)                                                                                                                                                             |
| 10.20      | 1991 Restated Stock Option Plan for Non-Employee Directors, assumed from ProCyte (14)                                                                                                                         |
| 10.21      | 1989 Restated Stock Option Plan, assumed from ProCyte (14)                                                                                                                                                    |
| 10.22      | Amended and Restated Employment Agreement with Jeffrey F. O'Donnell, dated October 30, 2007 (19)                                                                                                              |
| 10.23      | Amended and Restated Employment Agreement with Dennis M. McGrath, dated September 1, 2007 (19)                                                                                                                |
| 10.24      | Amended and Restated Employment Agreement of Michael R. Stewart, dated September 1, 2007 (19)                                                                                                                 |
| 10.25      | Employment Agreement of John F. Clifford, dated March 18, 2005 (2)                                                                                                                                            |
| 10.26      | Employment Agreement of Robin L. Carmichael, dated March 18, 2005 (2)                                                                                                                                         |
| 10.27      | Separation Agreement, effective June 30, 2006, between PhotoMedex, Inc. and John F. Clifford. (15)                                                                                                            |
| 10.28      | Restricted Stock Purchase Agreement of Jeffrey F. O’Donnell, dated January 15, 2006 (8)                                                                                                                 |
| 10.29      | Restricted Stock Purchase Agreement of Dennis M. McGrath, dated January 15, 2006 (8)                                                                                                                          |
| 10.30      | Consulting Agreement dated January 21, 1998 between the Company and R. Rox Anderson, M.D. (7)                                                                                                            |
| 10.31      | Restricted Stock Purchase Agreement of Jeffrey F. O’Donnell, dated May 1, 2007 (17)                                                                                                                     |
| 10.32      | Restricted Stock Purchase Agreement of Dennis M. McGrath, dated May 1, 2007 (17)                                                                                                                              |
| 10.33      | Restricted Stock Purchase Agreement of Michael R. Stewart, dated May 1, 2007 (17)                                                                                                                             |
| 10.34      | Restricted Stock Purchase Agreement of Michael R. Stewart, dated August 13, 2007 (18)                                                                                                                         |
| 10.35      | Amended and Restated 2000 Non-Employee Director Stock Option Plan, dated as of June 26, 2007 (17)                                                                                                             |
| 10.36      | Amended and Restated 2005 Equity Compensation Plan, dated as of June 26, 2007, as amended on October 28, 2008 (25)                                                                                            |
| 10.37      | Master Term Loan and Security Agreement, dated December 31, 2007 among PhotoMedex, Inc., CIT Healthcare LLC, as Agent and Lender, and Life Sciences Capital LLC, as Lender (20)                               |
| 10.38      | Omnibus Amendment dated September 30, 2008 by and among CIT Healthcare LLC, Life Sciences Capital LLC and PhotoMedex, Inc. (23)                                                                               |
| 10.39      | Amendment No. 1 to Omnibus Amendment, dated February 27, 2009 (24)                                                                                                                                            |
| 10.40      | Form of Indemnification Agreement for directors and executive officers of PhotoMedex, Inc. (24)                                                                                                               |
| 10.41      | Restricted Stock Purchase Agreement of Dennis M. McGrath, dated June 15, 2009 (28)                                                                                                                       |
| 10.42      | Restricted Stock Purchase Agreement of Michael R. Stewart, dated June 15, 2009 (28)                                                                                                                      |
| 22.1       | List of subsidiaries of the Company                                                                                                                                                                           |
| 23.1       | Consent of Amper, Politziner & Mattia LLP                                                                                                                                                                 |
| 31.1       | Rule 13a-14(a) Certificate of Chief Executive Officer                                                                                                                                                         |
| 31.2       | Rule 13a-14(a) Certificate of Chief Financial Officer                                                                                                                                                         |
| 32.1       | Certificate of Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002                                                               |
| 32.2       | Certificate of Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002                                                               |
|       |                                                                                                                                                                                                          |

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| (1)   | Filed as part of our Registration Statement on Form S-4, as filed with the Commission on October 18, 2002, and as amended. |
|-----------------|----------------------------------------------------------------------------------------------------------------------------|

| (2)   | Filed as part of our Registration Statement on Form S-4/A filed with the Commission on January 21, 2005, and as amended. |
|-----------------|--------------------------------------------------------------------------------------------------------------------------|

| (3)   | Filed as part of our Current Report on Form 8-K, dated November 6, 2006. |
|-----------------|--------------------------------------------------------------------------|

| (4)   | Filed as part of our Quarterly Report on Form 10-Q for the quarter ended June 30, 2000. |
|-----------------|-----------------------------------------------------------------------------------------|

| (5)   | Filed as part of our Annual Report on Form 10-K for the year ended December 31, 2002. |
|-----------------|---------------------------------------------------------------------------------------|

| (6)   | Filed as part of our Annual Report on Form 10-K for the year ended December 31, 2006. |
|-----------------|---------------------------------------------------------------------------------------|

| (7)   | Filed as part of our Registration Statement on Form S-1, as filed with the Commission on January 28, 1998, as amended. |
|-----------------|------------------------------------------------------------------------------------------------------------------------|

| (8)   | Filed as part of our Annual Report on Form 10-K for the year ended December 31, 2005. |
|-----------------|---------------------------------------------------------------------------------------|

| (9)   | Filed as part of our Current Report on Form 8-K, dated September 10, 2004. |
|-----------------|----------------------------------------------------------------------------|

| (10)   | Filed as part of our Quarterly Report on Form 10-Q for the quarter ended June 30, 2004. |
|------------------|-----------------------------------------------------------------------------------------|

| (11)   | Filed as part of our Current Report on Form 8-K, filed on April 6, 2006. |
|------------------|--------------------------------------------------------------------------|

| (12)   | Filed as part of our Current Report on Form 8-K, filed on April 10, 2006. |
|------------------|---------------------------------------------------------------------------|

| (13)   | Filed as part of our Definitive Proxy Statement on Schedule 14A, as filed with the Commission on November 15, 2005. |
|------------------|---------------------------------------------------------------------------------------------------------------------|

| (14)   | Filed as part of our Registration Statement on Form S-8, as filed with the Commission on April 13, 2005. |
|------------------|----------------------------------------------------------------------------------------------------------|

| (15)   | Filed as part of our Quarterly Report on Form 10-Q for the quarter ended March 31, 2006. |
|------------------|------------------------------------------------------------------------------------------|

| (16)   | Filed as part of our Quarterly Report on Form 10-Q for the quarter ended September 30, 2003. |
|------------------|----------------------------------------------------------------------------------------------|

| (17)   | Filed as part of our Quarterly Report on Form 10-Q for the quarter ended June 30, 2007. |
|------------------|-----------------------------------------------------------------------------------------|

| (18)   | Filed as part of our Quarterly Report on Form 10-Q for the quarter ended September 30, 2007. |
|------------------|----------------------------------------------------------------------------------------------|

| (19)   | Filed as part of our Annual Report on Form 10-K for the year ended December 31, 2007. |
|------------------|---------------------------------------------------------------------------------------|

| (20)   | Filed as part of our amended Annual Report on Form 10-K/A for the year ended December 31, 2007. |
|------------------|-------------------------------------------------------------------------------------------------|

| (21)   | Filed as part of our Current Report on Form 8-K filed on August 4, 2008. |
|------------------|--------------------------------------------------------------------------|

| (22)   | Fled as part of our Annual Report on Form 10-K for the year ended December 31, 2003. |
|------------------|--------------------------------------------------------------------------------------|

| (23)   | Filed as part of our Current Report on Form 8-K on February 27, 2009. |
|------------------|-----------------------------------------------------------------------|

| (24)   | Filed as part of our Current Report on Form 8-K on March 5, 2009. |
|------------------|-------------------------------------------------------------------|

| (25)   | Filed as part of our Definitive Proxy Statement on Schedule 14A on December 18, 2008. |
|------------------|---------------------------------------------------------------------------------------|

| (26)   | Filed with this Form 10-K. |
|------------------|----------------------------|

| (27)   | Filed as part of our Current Report on Form 8-K on January 26, 2009. |
|------------------|---------------------------------------------------------------------------|

| (28)   | Filed as part of our Quarterly Report on Form 10-Q for the quarter ended June 30, 2009. |
|------------------|----------------------------------------------------------------------------------------------|

| (29)   | Filed as part of our Current Report on Form 8-K on October 23, 2009. |
|------------------|---------------------------------------------------------------------------|

| (30)   | Filed as part of our Quarterly Report on Form 10-Q for the quarter ended September 30, 2009. |
|------------------|---------------------------------------------------------------------------------------------------|

| (31)   | Filed as part of our Current Report on Form 8-K on January 11, 2010. |
|------------------|----------------------------------------------------------------------|

| (32)   | Filed as part of our Current Report on Form 8-K on February 3, 2010. |
|------------------|----------------------------------------------------------------------|

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|                | PHOTOMEDEX, INC. |
|---------------------|------------------|
|                |             |
| Date: April 7, 2010 | By:              | /s/ Dennis M. McGrath |   |
|                |             | Dennis M. McGrath |
|                |             | President and Chief Executive Officer |

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| (1) | I have reviewed this annual report on Form 10-K of PhotoMedex, Inc.; |
|-----|---------------------------------------------------------------------------|

| (2) | Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report; |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|                | PHOTOMEDEX, INC. |
|---------------------|------------------|
|                |             |
| Date: April 7, 2010 | By:              | /s/ Dennis M. McGrath |   |
|                |             | Dennis M. McGrath |
|                |             | President and Chief Executive Officer |

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| (1) | I have reviewed this annual report on Form 10-K of PhotoMedex, Inc.; |
|-----|---------------------------------------------------------------------------|

| (2) | Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|                | PHOTOMEDEX, INC. |
|---------------------|------------------|
|                |             |
| Date: April 7, 2010 | By:              | /s/ Christina Allgeier |   |
|                |             | Christina Allgeier |
|                |             | Chief Financial Officer |

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