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**EXHIBIT 23.1**

**Consent      of Independent Registered Public Accounting Firm**

| (1)   | Registration                Statement (Form S-8 No. 333-133841) pertaining to the 1991 Employee                Stock                Plan of Genentech, Inc., |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (2)   | Registration                Statement (Form S-3 No. 333-37072) of Genentech,                Inc., |
|-----------------|---------------------------------------------------------------------------------------------------|

| (3)   | Registration                Statement (Form S-8 No. 333-115219) pertaining to the 1999 Stock                Plan,                1991 Employee Stock Plan, and 2004 Equity Incentive Plan of Genentech,                Inc., |
|-----------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (4)   | Registration                Statement (Form S-8 No. 333-87444) pertaining to the 1999 Stock Plan                of                Genentech, Inc., |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------|

| (5)   | Registration                Statement (Form S-8 No. 333-94749) pertaining to the Tax Reduction                Investment Plan of Genentech, Inc., |
|-----------------|---------------------------------------------------------------------------------------------------------------------------------------------------|

| (6)   | Registration                Statement (Form S-8 No. 333-90669) pertaining to the 1999 Stock Plan                and                1991 Employee Stock Plan of Genentech,                Inc., |
|-----------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (7)   | Registration                Statement (Form S-8 No. 333-83989) pertaining to the 1999 Stock Plan                and                1991 Employee Stock Plan of Genentech, Inc., and |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (8)   | Registration                Statement (Form S-8 No. 333-83157) pertaining to the 1990 Stock                Option/Stock Incentive Plan, 1994 Stock Option Plan, and 1996 Stock                Option/Stock Incentive Plan of Genentech,                Inc.; |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | /s/                ERNST & YOUNG LLP |
|--------|------------------------------------------|

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