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EXHIBIT 10.25



AMENDED AND RESTATED BACKUP FACILITY AGREEMENT

THIRD AMENDED AND RESTATED BACKUP FACILITY AGREEMENT dated as of November 4, 2004, among DNA FINANCE CORP. (the "Borrower"),the BANKS party hereto (the "Banks"), JP MORGAN CHASE BANK (formerly known as The Chase Manhattan Bank), as CP Administrative Agent and as Agent Bank (the "Agent"), UNION BANK OF CALIFORNIA, N.A., as Collateral Agent, VACAVILLE REAL ESTATE TRUST 2001 ("Lessor"), and GENENTECH, INC. ("Lessee" and "Guarantor").





WHEREAS, Borrower, Agent and the Banks hereto have heretofore entered into a Backup Facility Agreement dated as of October 26, 2001 (as amended prior to the Restatement Effective Date referred to below, the "Backup Facility Agreement"), and such parties, the Investors, Lessor, Lessee and certain other Persons have entered into the Participation Agreement referred to therein (as amended prior to the Restatement Effective Date referred to below, the "Participation Agreement"), and certain other Operative Agreements (as such term is defined in accordance with Section 1 below);



WHEREAS, at the date hereof, there are no Facility Loans outstanding under the Backup Facility Agreement; and



WHEREAS, the parties hereto desire to amend the Backup Facility Agreement, the Participation Agreement, and certain other Operative Agreements as set forth herein and to restate the Backup Facility Agreement in its entirety to read as set forth in the Backup Facility Agreement with the amendments specified below;



NOW, THEREFORE, the parties hereto agree as follows:



SECTION 1.  Defined Terms; References. Unless otherwise specifically defined herein, each term used herein which is defined in Annex A to the Participation Agreement shall have the meaning assigned to such term in such Annex A. Each reference to "hereof", "hereunder", "herein" and "hereby" and each other similar reference and each reference to "this Agreement" and each other similar reference contained in the Backup Facility Agreement shall, after the Restatement Effective Date, refer to the Backup Facility Agreement as amended and restated hereby.



SECTION 2.  Amendments



Upon the Restatement Effective Date:



(a)  Pursuant to Section 4.2 of the Backup Facility Agreement, the Banks agree that the current "Expiry Date" of November 4, 2004 shall be, and is hereby, extended to November 3, 2005, and each undersigned Bank shall remain a party to the Backup Facility Agreement as a Bank with an obligation to make (i) Revolving Facility Loans prior to its new Expiry Date in an aggregate principal amount not to exceed the amount of the Commitment set forth below, and (ii) a Term Loan in the amount of such Commitment on the terms set forth in the Backup Facility Agreement, in each case as such amounts may be adjusted from time to time as provided in the Backup Facility Agreement.



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(b)  The parties hereto agree that the Backup Facility Agreement and the Participation Agreement are each amended, as of the Restatement Effective Date, by replacing the Commitment amounts on the signature pages thereof, with the Commitments shown on Schedule 1 attached hereto.



(c)  The pricing grid appearing in the definition of "Applicable Margin" in Annex A to the Participation Agreement is replaced with the following:





|Level |  | Index Debt Ratings
(S&P/Moody's)
(whether express
or implied) |  | Eurodollar
Spread
(basis points) |  | ABR
Spread/
Loans
(basis points) |  | ABR Spread/
Investor Yield
(basis points) |  | Facility
Fee Rate
(basis points) |  | Eurodollar
Spread/
Investor Yield
(basis points) |  | Facility
Fee Rate/
Investor Yield
(basis points)
|----- |  | ------------------------------------------------------------- |  | -------------------------------- |  | -------------------------------- |  | ----------------------------------------- |  | -------------------------------- |  | ------------------------------------------------ |  | ------------------------------------------------
|      |  |                                                               |  |                                  |  |                                  |  |                                           |  |                                  |  |                                                  |  |                                                 
|I     |  | ≥ A / A2                                                      |  | 40.0                             |  | 0                                |  | 100                                       |  | 10.0                             |  | 37.5                                             |  | 12.5                                            
|II    |  | ≥ A- /A3                                                      |  | 62.5                             |  | 0                                |  | 125                                       |  | 12.5                             |  | 60.0                                             |  | 15.0                                            
|III   |  | ≥ BBB+ /Baa1                                                  |  | 85.0                             |  | 0                                |  | 150                                       |  | 15.0                             |  | 82.5                                             |  | 17.5                                            
|IV    |  | ≥BBB /Baa2                                                    |  | 132.5                            |  | 50                               |  | 200                                       |  | 17.5                             |  | 130.0                                            |  | 20.0                                            
|V     |  | < BBB/ Baa2                                                   |  | 177.5                            |  | 100                              |  | 250                                       |  | 22.5                             |  | 175.0                                            |  | 25.0                                            



(d)  In the definition of "Investor Yield Rate" in Annex A to the Participation Agreement, the term "Facility Fee Rate" is hereby deleted and replace with the term  "Facility Fee Rate/Investor Yield", and the term "Eurodollar Spread" is hereby deleted and replace with the term  "Eurodollar Spread/Investor Yield".



(e)  In the definition of "Backup Facility Commitment" in Annex A to the Participation Agreement, the amount "$479,859,000" is hereby deleted, and the amount "$420,495,000" is hereby substituted therefor.



(f)  In Section 2.1(a) of the SPC Loan Agreement, the amount "$470,450,000" is hereby deleted, and the amount "$412,250,000" is hereby substituted therefor.  The parties hereby agree that as of the date hereof, the outstanding balance of Tranche A SPC Note is $371,761,528.38 and the outstanding balance of Tranche B SPC Note is $40,488,471.62.



(g)  The parties acknowledge that neither the Lessee nor the Lessor shall have any further right to requisition funds for the purpose of paying Permitted Leasehold Improvement Costs.



SECTION 3.  Representations and Warranties. Each of Lessee, Borrower, and Guarantor hereby represents and warrants that (i) its respective representations and warranties contained in the Participation Agreement and the Operative Agreements are, after giving effect to this Amendment and Restatement, true and correct in all material respects on and as of the Restatement Effective Date, and (ii) no Default will have occurred and be continuing as to it on such date.



SECTION 4.  Governing Law.  This Amendment and Restatement shall be governed by and construed in accordance with the laws of the State of New York.



SECTION 5.  Counterparts.  This Amendment and Restatement may be signed in any number of counterparts, each of which shall be an original, with the same effect as if the signatures thereto and hereto were upon the same instrument.



SECTION 6.  Effectiveness.  This Amendment and Restatement shall become effective on the date when the following conditions are met (the "Restatement Effective Date"):



(a)  the Agent shall have received from each of the Borrower, the Banks, the Lessor, the Lessee, and the Guarantor a counterpart hereof signed by such party or facsimile or other written confirmation (in form satisfactory to the Agent) that such party has signed a counterpart hereof;



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(b)  the Agent shall have received an opinion of in house counsel to Lessee, dated the Restatement Effective Date, in form and substance satisfactory to the Agent; and

(c)  the Agent shall have received all documents the Administrative Agent may reasonably request relating to the existence of the Lessee, the authority for and the validity of this Amendment and Restatement, and any other matters relevant hereto, all in form and substance satisfactory to the Agent.



SECTION 7.  Continuing Effect of the Participation Agreement and Operative Agreements. Except as expressly provided herein, this Agreement shall not constitute an amendment or waiver of any other provision of the Backup Facility Agreement, the Participation Agreement or any Operative Agreement not expressly referred to herein and shall not be construed as a waiver or consent to any further or future action on the part of Lessee, the Lessor, Borrower or Guarantor that would require a waiver or consent of the Agent Bank, the Investors and/or the Banks except as may be provided for herein.  Except as expressly amended hereby, the provisions of the Participation Agreement and the Operative Agreements (together with any consent or waiver heretofore delivered pursuant thereto) are and shall remain in full force and effect.



SECTION 8.  Expenses. Lessee agrees to pay or reimburse the Agent and Borrower for all of their reasonable out-of-pocket costs and expenses incurred in connection with the preparation, negotiation and execution of this Agreement, including, without limitation, the fees and disbursements of their counsel.



SECTION 9.  Construction. The fact that all the parties hereto executed this Agreement should not be construed as requiring all such parties to execute or consent to any particular amendment of any Operative Agreement.



SECTION 10.  Instruction. The Agent, Borrower and the Lessor are hereby instructed to execute this Agreement.



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IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed by their respective authorized officers as of the day and year first above written.





| | GENENTECH, INC., as Lessee and Guarantor
By:  /s/ LOUIS J. LAVIGNE
            Name: Louis J. Lavigne
            Title: Executive Vice President and 
                       Chief Financial Officer                                                                                            
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                                                  
| | DNA FINANCE CORP., as Borrower
By:  /s/ FRANK B. BILOTTA
            Name: Frank B. Bilotta
            Title: President                                                                                                                                                                         
| |                                                                                                                                                                                                                                                                                                  
| | VACAVILLE REAL ESTATE TRUST 2001, as
Lessor
By:  Wilmington Trust Company, not in its 
         individual capacity but solely as Trustee
            By:  /s/ MICHAEL G. OLLER, JR.
                    Name: Michael G. Oller, Jr.
                    Title: Senior Financial Services Officer
| |                                                                                                                                                                                                                                                                                                  
| | JPMORGAN CHASE BANK, as Bank and as
Agent Bank 
By:  /s/ DAWN LEE LUM
            Name: Dawn Lee Lum
            Title: Vice President                                                                                                                                                           
| |                                                                                                                                                                                                                                                                                                  
| | JPMORGAN CHASE BANK, as CP
Administrative Agent
By:  /s/ ANDREW TAYLOR
            Name: Andrew Taylor
            Title: Vice President                                                                                                                                                         



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| |                                                                                                                                                          
| | ---------------------------------------------------------------------------------------------------------------------------------------------------------
| | UNION BANK OF CALIFORNIA, N.A., as
Collateral Agent 
By:  /s/ SANDRA HANRAHAN
           Name: Sandra Hanrahan
           Title: Assistant Vice President
| |                                                                                                                                                          
| |                                                                                                                                                          
| | BNP PARIBAS, as a Bank                                                                                                                                   
| |                                                                                                                                                          
| | By:  /s/ PIERRE NICHOLAS ROGERS
            Name: Pierre Nicholas Rogers
            Title: Managing Director                                            
| |                                                                                                                                                          
| | By:  /s/ KATHERINE WOLFE
            Name: Katherine Wolfe
            Title: Director                                                                   
| |                                                                                                                                                          
| |                                                                                                                                                          
| | CREDIT SUISSE FIRST BOSTON, acting through
its Cayman Islands Branch, as a Bank                                                                          
| |                                                                                                                                                          
| | By:  /s/ PAUL L. COLON
            Name: Paul L. Colon
            Title: Director                                                                       
| |                                                                                                                                                          
| | By:  /s/ KARIM BLASETTI
            Name: Karim Blasetti
            Title: Associate                                                                    
| |                                                                                                                                                          
| |                                                                                                                                                          
| | UBS AG, STAMFORD BRANCH, as a Bank                                                                                                                       
| |                                                                                                                                                          
| | By:  /s/ WILFRED V. SAINT
            Name: Wilfred V. Saint
            Title: Director Banking Products Services, US                                   
| |                                                                                                                                                          
| | By:  /s/ LOUIS PISTECCHIA
            Name: Louis Pistecchia
            Title: Director Banking Products Services, US                                   
| |                                                                                                                                                          



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| | WACHOVIA BANK, NATIONAL ASSOCIATION, as a Bank                                                      
| | ----------------------------------------------------------------------------------------------------
| |                                                                                                     
| | By:  /s/ ROBERT SEVIN
            Name: Robert Sevin
            Title: Director                    
| |                                                                                                     
| |                                                                                                     
| | ABN AMRO BANK, N.V., as a Bank                                                                      
| |                                                                                                     
| | By:  /s/ ERIC OPPENHEIMER
            Name: Eric Oppenheimer
            Title: Director            
| |                                                                                                     
| | By:  /s/ MICHELE COSTELLO
            Name: Michele Costello
            Title: AVP                 
| |                                                                                                     
| |                                                                                                     
| | MELLON BANK, N.A., as a Bank                                                                        
| |                                                                                                     
| | By:  /s/ LAWRENCE C. IVEY
            Name: Lawrence C. Ivey
            Title: First Vice President
| |                                                                                                     
| |                                                                                                     
| | BANK OF NEW YORK, as a Bank                                                                         
| |                                                                                                     
| | By:  /s/ JONATHAN ROLLINS
            Name: Jonathan Rollins
            Title: Vice President      



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SCHEDULE 1



COMMITMENT SCHEDULE





|Bank                                | Commitment
|----------------------------------- | ----------
|                                    |           
|JPMORGAN CHASE BANK                 | $         
|BNP PARIBAS                         | $         
|CREDIT SUISSE FIRST BOSTON          | $         
|UBS AG, STAMFORD BRANCH             | $         
|WACHOVIA BANK, NATIONAL ASSOCIATION | $         
|ABN AMRO BANK, N.V.                 | $         
|MELLON BANK, N.A.                   | $         
|BANK OF NEW YORK                    | $         
|                                    |           
|TOTAL                               | $         



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