NATL INST. OF STAND & TECH

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PUBLICATIONS

Nisr United States Department of Commerce

National Institute of Standards and Technology

NIST Technical Note 1554

Characterization of Tissue-Equivalent

IViaterials for High-Frequency

Applications (200 MHz to 20 GHz)

Jannes Baker-Jarvis

Sung Kim

Luke E. Schallinger

Justin Johnson

Brad Givot

QC

100

U5753

^1554

2010

c 2

NIST Technical Note 1554

Characterization of Tissue-Equivalent

IVIaterials for IHigh-Frequency

Applications (200 MHz to 20 GHz)

tjames Baker-Jarvis

tSung Kim

+Luke E. Schallinger

tJustin Johnson

+Brad Givot

TElectromagnetics Division, IVIS 818.01

National Institute of Standards and Technology

325 Broadway

Boulder, CO 80305-3337

+3MC0

St. Paul, Minnesota

July 2010

^<""''%.

^^ATBSO^^

U.S. Department of Commerce, Gary Locke, Secretary

National Institute of Standards and Technology, Patrick D. Gallagher, Director
National Institute of Standards and Technology Technical Note

Natl. Inst. Stand. Technol., Tech. Note 1554. 32 pages (July 2010)

CODEN:NTNOEF

U.S. GOVERNMENT PRINTING OFFICE

WASHINTON:2010

For sale by the Superintendent of Documents, U.S. Government Printing Office, Washington, DC 20402-9325
Contents

1 Introduction 2

1 .

Overview of the Problem 2

1.2 Electrical Properties of Tissue-Equivalent Materials 3

2 Previous Research on the Dielectric Properties of Human Tissue 4

3 Dielectric Measurement Methods for

Tissue-Equivalent Materials 5

3.1 Solid Simulants 6

3.2 Liquid Simulants 7

3.3 Agar and Agarose-Based Tissue-Equivalent Materials 11

4 Discussion 20

5 References 20

A Appendix: Fundamental Electromagnetic Parameters and Concepts Used in Material

Characterization 22

lU

Characterization of Tissue-Equivalent Materials for

High-Frequency Applications (200 MHz to 20 GHz)

James Baker-Jarvisf Sung Kim*

Luke E. SchallingerJ Justin Johnsonjand Brad Givot ^

The purpose of this report is to summarize the characterization of a number of high-frequency

solid, liquid, and semisolid tissue-equivalent materials, from 200 MHz to 20 GHz. Carbon

black and liquid mixtures were studied, but were found to be unsuitable for matching both

the real and imaginary parts of the permittivity over a broad range of frequencies. Agar and

agarose-based materials produced stable materials whose real and imaginary parts of the permittivity exhibited the required dispersive characteristics and could be easily tuned to fit a

specific application and over a given frequency range.

Key words: Agarose; carbon-black; dielectric; frequency; permittivity; phantom.

* National Institute of Standards and Technology, Electromagnetics Division, MS 818.01, Boulder. CO 80305

t3M Co., St. Paul, MN 55144-1001
1. Introduction

1.1 Overview of the Problem

Many research areas require electrical tests that use phantom materials with properties similar to

that of the various tissues of the human body, over various frequency bands. In the past, tissueequivalent materials have been used for applications that include studies on the low-frequency

electromagnetic wave interaction with the human body, through-the-wall imaging, the interaction

of medical implant devices, and the interaction of wireless transmitters with human tissue [1]. The

conductivities and permittivities of the human body are highly inhomogeneous, and bone, blood,

muscle, etc.; all have different permittivities and conductivities. Since the permittivity of human

tissue is frequency dispersive, it is important that the simulant material mimics the frequencydependent properties.

The interaction of biological tissues with electromagnetic waves is related to the conductivity

and dielectric properties that are modeled through the permittivity 8* (co) = 8o(e^(co) — j{Gdc/^^+

8'/(co)), where 8o « 8.854 x 10"^-^ (F/m), co is the radian frequency (CO = 27i/), relative to the

complex time dependence exp(7Cor), j = %/^, and the dc conductivity is g^c (S/m). Since the

real part of the permittivity is related to the impedance, it affects the reflectivity of an incident wave. The imaginary part of the permittivity relates to the wave attenuation as it passes into a material. The magnetic permeability of tissue-equivalent materials is very nearly that of free

space, ^0 = 471 X 10~^ (H/m).

Various forms of tissue-equivalent materials have been studied by many researchers [2-14].

Previously developed phantom materials have been based on liquids and salts, gels, and carbonblack mixtures. For example, Hagmann et al. used glycine, salt, and the gelling agent, car- rageenan [7]. With this mixture, they found they could match the permittivity and conductivities of the human body at lower frequencies. Materials that have dielectric properties similar

to those of human tissue are most easily obtained by use of water-based mixtures. Usually the re- searcher requires materials that have time-stable properties. In addition, the materials must possess

frequency-dispersive properties similar to human tissue. For this reason many different simulant

materials have been developed over the years.

Kato et al [10] and Onishi et al. [4] used mixtures of agar, water, and salts. Kato found that the

semi-solid material could be sculptured to produce a body shape, but it degraded in time. Chou

et al. [8] used a mixture of water, salts, and a gelling agent to form a semi-solid material. A

useful recipe for agar materials is given in [4]. Andreuccetti at al. [9] used a mixture of water,

polyacrylamide, and salts to produce a semi-solid phantom. Marchal et al. [12] used a mixture of

water, salts, and gelatine to produce a stable jelly-like phantom material. Addition of a preservative

alleviates most of the time-stability problems. Most of the previous studies that dealt with low fre-
quencies used liquid materials, while the studies that dealt with megahertz to gigahertz frequencies

used semi-solid materials [11]. Liquids work well as phantom materials for the dielectric loss at low frequencies because the mobile ions from the salts mimic the tissue's dielectric-loss response.

However, the real part of the permittivity of most liquid phantoms is too high to match that of

human tissue. The standard method for measuring the Specific Absorption Rate (SAR) caused by

wireless communication devices uses a liquid mixture of water, NaCl, alcohol, sugar, and other

additives, depending on the frequency [13]. The IEEE Standard uses a mixture of water, NaCl,

sugar, and other compounds, as indicated in IEEE Standard Method 1528.

In our study the goal was to find materials that are time stable and easy to produce, and can be

used from 200 MHz to 20 GHz. We considered carbon black mixed into silicone rubber (CBS),

liquids, and agar and agarose-based composites mixed with powdered ethylene. Most of these

composites can be mixed to match the average conductivity of the human body tissues, but the

properties of the semi-solid materials most closely matched our criteria.

1.2 Electrical Properties of Tissue-Equivalent IVIaterials

For a material that is homogeneous, linear and isotropic, the complex permittivity 8 is defined by

D(a)) = 8(o))E(co), where E is the complex time-harmonic, steady-state electric field intensity, and

D is the corresponding displacement vector. In conductive media. Maxwell's curl relation for the magnetic field intensity H is given by

V X H(co) = yco8oej.(co)

We define the effective loss tangent as i->i^+ "''

8'^(C0) C08o8'^(CO)

E(co). (1)

tan5,(cD) = 4fJ + ^^!^. (2)

The two terms in Eq.(2) represent different effects that are responsible for the conductive loss in a material. We identify these terms in the following manner. The frictional losses due to dipole

movement are related to

and the dc conduction losses are modeled as

tan 6,, (CO) = ""f" . . (4)

C08o8'^(co)

The term tan6Qr represents losses in materials classified as dielectrics or insulators where there are

essentially no free charge carriers. At the other extreme, tan5,„ dominates in highly conductive
liquids and metals. The complex permittivity including the conductivity is defined as

8* = e;eo-7(ereo + ^). (5)

CO The conductivity Oj^ is nearly independent of frequency in the rf and microwave bands, but o^// =

eocoe'/ increases nearly linearly for many lossy solids and semisolids.

Fields attenuate as they enter materials that have loss and can be modeled as a damped ex- ponential E{x) — Eqcxp {—x/bs). The skin depth ds is the distance a plane wave travels until its magnitude decreases by 1 /e and is defined for lossy dielectric materials as

. V2c I 05 = — / =

(6)

"^ v/iXV\/l+tan25^-l

In Eq.(6) 5^ reduces in the low conductivity limit to 6^ -^ 2cy^/co-y//j^£'/. Tissues have medium

to high loss so it is better to use the exact equation Eq. (6) to calculate skin depth. From Eq.(6), we

see that the frequency, permittivity, and permeability of the material determine the skin depth. The

higher the frequency, permeability, and conductivity, the shorter the skin depth [15]. The depth of

penetration Dp = 5^/2 is the depth where the energy in the wave drops to l/e of its value on the

surface. The skin depth in human tissues is on the order of 5 cm at 500 MHz to 1 cm at 5 GHz.

Gabriel and Gestblom have compiled extensive data on various human tissues and developed a database that reports measurements of various human tissues such as head, brain, muscle, fat, and

bone [16].

The wavelength of an electromagnetic wave in a material is influenced by the permittivity:

X « Cvac/\/^'rPrf, whcrc Cyac IS the spccd of light in vacuum. The impedance is a strong function of Cdc at low frequencies. For TEIVI waves, the plane-wave impedance is Z = ^Jjj*/z* =

yjjiHiJ /

{jQdz' + <5(ic) and Zq = \/Jio/£o is the impedance of free space; the plane-wave reflection

coefficient is given by

r, = ^:^. (7) ^ Z + Zo

Most conductive semisolid materials have an effective conductivity that is relatively constant below

100 MHz and then increases with frequency above 100 MHz. This indicates that dc conduction

dominates at low frequencies, but as the frequency increases the dielectric loss also contributes.

2. Previous Research on the Dielectric Properties of Human

Tissue

Schwan, Foster, Stuchly, Gabriel [2, 17, 18], and others performed studies on dielectric properties

of human tissues. Gabriel's results are summarized in a database [18, 19]. Typical results are
displayed in Figs. 1, 2, and 3. Note the behavior of the conductivity from low frequency to 20

GHz. Below 200 MHz the conductivity is relatively flat, but it increases almost linearly at higher

frequencies up to about 20 GHz and then the slope decreases. This is due to the transition from dc

conductivity to dielectric relaxation. The body is a complicated mixture of organs and materials

with widely varying dielectric properties, and so choosing an effective material that matches the

average body properties as a function of frequency is difficult and only approximate.

50-

40-

J30-

D 20-

10-

o4

blood bone cortical muscle

skin dry

skin wet

fat

n \

1

10 20 30 Frequency (GHz)

40 50

Figure 1 . Measurements of the conductivity (S/m) of various body tissues by Gabriel and Gestblom

[16] (no uncertainties assigned).

In Fig. 4 we display the skin depth of human skin as a function of frequency. We see that even

at 10 GHz the wave penetrates around 4 mm into the skin layer and into the muscle and bone. At

100 MHz the skin depth is nearly the thickness of the body. As a consequence, simulating human

body properties by spray-on paints or thin veneers on a manikin may work for a specific frequency,

but will fail over a broad band of frequencies.

3. Dielectric Measurement Methods for

Tissue-Equivalent Materials

Over the years, there has been an abundance of methods developed for measuring the complex

permeability and permittivity of lossy materials. These techniques include free-space methods,

open-ended coaxial-probes, cavity resonators, dielectric-resonator techniques, and transmissionline techniques [20]. Each dielectric measurement method has a niche. For example, techniques
T

10 20 30 Frequency (GHz)

— blood

•-• bone cortical - muscle

skin dry

skin wet

fat

50

Figure 2. Measurements of the relative permittivity of various body tissues by Gabriel and Gestblom [16] (no uncertainties assigned).

based on cavities are accurate, but not broadband, and are usually limited to low-loss materials.

Nondestructive techniques, although not the most accurate, are very attractive because they maintain the integrity of the material. Tissue-equivalent materials are lossy, and consequently resonance methods are difficult to use. Therefore the researcher must use a transmission-line method of some

type. For semi-solid materials, open-ended coaxial probes, as shown in Fig. 5, are easy to apply.

We used coaxial probes with apertures from 3.5 mm to 14 mm for most of the measurements in

this report. However, the 8^ measured by coaxial probes are influenced by air gaps between the

material under test and the fixture. This air gap influence is less severe for semisolid materials than

for solid materials. As a check on our probe operation we commonly measure standard liquids. In

Fig. 6 the real and imaginary parts of methanol are plotted for measurements with a 14 mm probe.

As another test, we measured ham as a function of frequency because it has properties similar to human tissue, but, is of course not a standard material (see Figs. 7 and 8). The uncertainty analysis

we used for the coaxial probe measurements was based on the analysis given in Ref. [21] that uses

the root-mean square (RMS) method.

3.1 Solid Simulants

For use as a candidate tissue-equivalent material we developed a carbon black silicone composite

in collaboration with 3M Co. and Dyneon, Inc. Measured data for this material are shown in Figs.

9 and 10. These materials can be made so that the e^ and dispersive characteristics approximately
1.4-

1.2-

1.0- C 0.8-1 ^ 0.6-1:

0.0-1,

blood bone cortical - - muscle

skin dry

skin wet

fat

"1

\ \ 10 20 30 Frequency (GHz)

40 50

Figure 3. Measurements of the loss tangent of various body tissues by Gabriel and Gestblom [16]

(no uncertainties assigned).

match those of human body tissues. However, we cannot design these materials to match simultaneously both e'^ and e'^. In Fig. 1 1, we show how the conductivity of carbon black in a polymer

base varies as a function of the carbon black concentration from 1 kHz to 1 MHz. In addition, these

materials are difficult to manufacture reproducibly. For the carbon black composite, the Type B

expanded relative uncertainty for e'^, U = kuc = 3.0 (k=2). We have observed that obtaining highly

repeatable measurements on carbon-black composites is difficult. This is due to the heterogeneity

of the material. In order to understand the various measurement issues in measuring carbon-black

composite materials we participated in an intercomparison with the National Physical Laboratory

of UK (NPL) and a number of industrial partners. The material was a mixture of graphite and

polymer. Each group in the study received samples of the materials from the same manufacturer

and measured the materials with their in-house methods. Because each participant's material was

from a different batch, any manufacturing inhomogeneities or batch-to-batch variations influenced

the measurements. The results of these measurements are given in Figs. 12 and 13. This intercomparison shows that measurements on these artificial materials generally have large systematic

uncertainties associated with them that are due to inhomogeneities and the effects of air gaps.

3.2 Liquid Simulants

Solutions of water mixed with salts can be developed that exhibit the appropriate conductiviiy in

the microwave range. However, the proper values for e'^ are difficult to obtain. In Fig. 14. ihc dc
• Wet Skin Dry Skin

1 r

5 10 15 Frequency (GHz)20

Figure 4. The calculated skin depth in millimeters from the skin data of Gabriel and Gestblom 116].

Figure 5. Some of the open-ended coaxial probes used in this research
1

1 r

0.5 1.0 1.5 2.0 Frequency (GHz)

1-20

- 15

- 10-

-5

ho

2.5 3.0

Figure 6. Measurements of £^ and £'/ for methanol at lO'^C by use of a 14 mm open-ended coaxial

probe. For measured e'^, the Type B expanded relative uncertainty was U — kuc — 1 .5 (k=2), where

k is coverage factor.

CO

80-1

70-

•60-

50-

40 -L "1 \ \ r

0.5 1.0 1.5 2.0 Frequency (GHz)

2.5 3.0

Figure 7. The real part of the permittivity of cooked, processed ham as a function of frequency.
400-11

300-

200-

100-

0-L 1 \

1 r

0.5 1.0 1.5 2,0 Frequency (GHz)2.5 3.0

Figure 8. The loss factor of cooked, processed ham as a function of frequency.

conductivity of potassium chloride water solutions (KCl) in 500 ml deionized water is plotted for

various concentrations of salts. The uncertainties in the liquid measurement are due to uncertainties

in the measurement device and uncertainties in the chamber temperature. Measurements in our lab

have a temperature stability of ±2 ^C.

The conductivities of liquids that contain free ions from salts are approximately independent

of frequency. This is in contrast to tissues, where the conductivity increases for frequencies above

100 MHz. This is probably due to interfaces in the materials.

We also measured another liquid mixture that contained a 50-50 mix of ethylene carbonatepropylene carbonate with the salt tetraethyleammonium tetrafluoroborate (TEATFB) developed by

Broadhurst et al. [5]. Measured data are shown in Fig. 15. We found that by varying the salt concentration we could vary the conductivity over the desired range found in human tissues. The

following formula as derived from Fig. 14 approximates the conductivity data as a function of

grams of TEATFB (mtea) per 100 g of propylene carbonate:

a = 0.0095 + .0725mtea - 0.001 12m"tea" (8)

10
50

40-

30-

20-

10-1-

Carbon Black

0.2 0.4 0.6 0.8 Frequency (GHz)

1.0

Figure 9. The permittivity of a polymer carbon black composite.

3.3 Agar and Agarose-Based Tissue-Equivalent Materials

Although the conductivities of human tissues can be simulated by conducting liquids, the real part

of the permittivities of these liquids does not match that of human tissue. In order to find a better

material, we have developed agar and agarose-based materials, as shown in Fig. 16, which shows

a simulant human hand. Agarose is polysaccharide obtained from agar that is the most widely

used medium for gel electrophoresis tests. We found that we could vary both the conductivity,

dispersion, and the real part of the permittivity by changing the proportions of the constituents.

The conductivity was varied by changing the amount of potassium chloride phosphate buffered

saline (PBS) included. The real part of the permittivity was varied by adding polyethylene powder.

A preservative is usually added to prevent agar decomposition. In Figs. 17 and 18 we present the

real and imaginary parts of permittivity measurements for agar composites, without polyethylene,

from 500 MHz to 20 GHz as measured with a 3.5 mm open-ended coaxial probe. Figs. 19 and 20

show results of measurements with a 14 mm coaxial probe from 100 MHz to 2 GHz on an agarose

material with added polyethylene powder. Figs. 21 through 24 show measurements on another

mixture of agarose through the use of 14 mm and 3.5 mm probes. These results are compared to a mixture with 7 % by weight of polyethylene. For agar mixture recipes see Onishi et al. [4].

11
0.4 0.6 Frequency (GHz)

1.0

Figure 10. The conductivity of a polymer carbon black composite.

T3C

OU

1.2

1.0

0.8

0.6

0.4

0.2

Ih

10"

-•- Silicone + 5% Carbon Black by weight -©- Silicone + 6% Carbon Black by weight -A- Silicone + 7% Carbon Black: measurements of 6 different samples -a- Silicone + 8% Carbon Black -- Silicone + 10% Carbon Black

D DDD DDDD DD D DD DDDD D DDD D Jl

-k—k kkk kkkk AAA AAA kkkk k—A A AA Ai . -A

A AAA AAAA AAA AAA AAAA A—A AAA Ai >

O.Ot-^"

^

I §||igi^g§ ,|§| §tt|i§i^g§ ,| ffl a||igi|

10 10

Frequency (Hz)

10

Figure 1 1 . The conductivity of silicone as a function of added carbon black and frequency.

12
40% graphite powder hand mix

0.8

0.7

0.6

I 0.5

- TBWI Line IX meas NR.WG8 waveguide

NPLWG4 waveguide

NPL 7mm co-ax

- TBVl Line Nokia meas

NIST coax (14mm)

1000 1500 2000

frequency (Ml-b)

3000

Figure 12. The round-robin measurement results for the conductivity of a graphite-polymer composite.

40% graphite powder hand mix

25

20 V.

g It)

a.$ 10

•-....! .^---.^"*-*-»<

'^^-itt--^ ''"""-•..

^^^^^^^^~;*-^l«--^l«--^K--^^ -^1^-*-^.^-*-*—

s

—»— TEM Line IX rreas —•— NFL WG8 w aveguide'~

3

at NFL WG4 waveguide 1 5

• NPL 7mm co-ax —SIS— TEM Line Nol<ia meas

C

• NIST coax (14mm)

) 500 1000 1500 2000 2500 3000

frequency (MHz)

Figure 13. The round-robin measurement results for e'^ of the graphite-polymer composite.

13
KCI Solution

1.2

to,

•5

E

oO

o

Q

KCI added to 500 ml deionized water

-I I I I I I I L

O a =-0.002 + [.322X(gramsofKCL)l(20.5-21-7C) O CT =0.011 + [.363 X(gnams of KCL)i (22.0- 22.3 C) C a = 0.034 + [.364 X (grams of KCL)] (22.6-22.8 C) _1 I I I I I I I I I I I I l_

KCI (grams)

Figure 14. Conductivity of KCI solution versus concentration and temperature.

•> 0.4 -

o

3coU

8 10 12 14

Grams TEATFB

Figure 15. The dc conductivity of the TEATFB solution containing 100 ml propylene carbonate

and 1 25 g ethylene carbonate as a function of TEATFB concentration.

14
» ' ' - £_ -J

f_, (.- (o r<r i • '• - 1= r^- (^ r.- r' i. 1

(- -...i..-

Figure 16. Phantom hand made from a glove filled with agarose

to

ii^-. OX PBS

/u- ^^^^^=550_-.

,

0.25XPBS

^^^^"•, - - 0.5XPBS

0.75X PBS

60- IX PBS

^N^V>>. ^^iN?-- ^S^^.

^^sS>:-, 50-

^Vir^"-. ^<^ov>%

^*^^^o^*

^^^^i^^y'^- ^^v::-^''- ^S^v*..', 4U-

^^^s^r~Q''

1 1 1 10 15 20 Frequency (GHz)

Figure 17. Real part of the permittivity of an agarose-based material as a function of frequency.

15
w

50^

40

30-

20-

10-,

0-

10 Frequency (GHz)

ox PBS

0.25XPBS - - 0.5X PBS

0.75X PBS

1X PBS

15 20

Figure 18. Loss factor of an agarose-based material as a function of frequency.

7060-

50-

40-

30

20

10-1

0-

0.0 0.5 10 1.5 2.0

Frequency (GHz)

2.5

~~1

3.0

Figure 19. z[ of agarose mixed with polystyrene powder as measured with a 14 mm coaxial probe.

The top curve is for agarose with no polyethylene powder, and the lower curves are for 15 % and

25 % polyethylene powder added.

16
200-

160-

> 100 -

Frequency (GHz)

Figure 20. Loss factor of agarose mixed with polystyrene powder as measured with a 14 mm

coaxial probe. The top curve is agarose with no polyethylene powder and the lower curves are with 15 % and 25 % polyethylene powder included.

uu -

80- ^^^

60- "^—~~~~^^^;i:--.

40-

^^^"^""^"^^^^---^

20- 7%

control -

1 1 1 1 10 15 20 Frequency (GHz)

Figure 21. The real part of the permittivity for agarose-based specimens measured from 500 MHz

to 20 GHz with a 3.5 mm coaxial probe. The top curve is agarose with no polyethylene powder

added and the lower one is for agarose with 7 % polyethylene powder added.

17
40 -t

30-

Lr 20-

10-

1 10 Frequency (GHz)

15 20

Figure 22. The loss factor for agarose-based specimens measured from 500 MHz to 20 GHz with

a 3.5 mm coaxial probe. The top curve is for agarose with no polyethylene powder added and the

lower one with 7 % polyethylene powder added.

1.4 - :/

1.2- ,.->^

1.0- .-y^ ^ 0.8- c ^;>^

^ 0,6- .-.y^^"^

0.4- 7%

0.2- control

—

1 1 1 1 10 15 20 Frequency (GHz)

Figure 23. The loss tangent for agarose-based specimens measured from 500 MHz to 20 GHz with

a 3.5 mm coaxial probe. The top curve is for agarose with no polyethylene powder, and the lower one is with polyethylene powder.

18
40-1

Frequency (GHz)

Figure 24. The conductivity for agarose-based specimens measured from 500 MHz to 20 GHz

with a 3.5 mm coaxial probe. The top curve is for agarose with no polyethylene powder added and

the lower one is for agarose with polyethylene powder added.

19
4. Discussion

We have shown that conductivities with a few percent of those of tissues in the human body can be

reproduced by either sohd carbon-black composites, various conducting solutions, or semi-solid

agarose-based materials. The real part of the permittivity can most easily be produced by agar

and agarose-based materials with polyethylene powder added. The liquids can easily be mixed to obtain the desired response. These liquids also show good time stability. We found that as the

fraction of polyethylene powder was increased above 15 % by weight the structural integrity of the

material was degraded.

We acknowledge the support of Office of Law Enforcement Standards (OLES) at NIST and the

National Institute of Justice and discussions with Nick Paulter of the of OLES.

5. References

[1] K. L. Stricklett and J. Baker-Jarvis, Electrical Properties of Biological Materials: A Bibliographic Survey. 2001. NIST IR 6564.

[2] K. R. Foster and H. R Schwan, Dielectric properties of tissues and biological materials: A

critical review, vol. 17, pp. 25-104. CRC Press, 1989.

[3] O. Martinsen, S. Grimmes, and H. Schwan, "Interface phenomena and dielectric properties

of biological tissues," Encyclopedia of Surface and Colloid Science, p. 2643, 2002.

[4] T. Onishi, R. Ishido, T. Takimoto, K. Saito, S. Uebayashi, M. Takahashi, and K. Ito, "Biological tissue-equivalent agar-based solid phantoms and SAR estimation using thermographic

method in the range of 3-6 GHz," lEICE Trans. Commun., vol. E88-B, pp. 3733-3740, 2005.

[5] M. G. Broadhurst, C. K. Chiang, and G. T Davis, "Dielectric phantoms for electromagnetic

radiation," J. Mole. Solids, vol. 36, pp. 47-64, 1987.

[6] T. Kobayashi, T Nojima, K. Yamada, and S. Uebayashi, "Dry phantom composed of ceramics and its application to SAR estimation," IEEE Trans. Microwave Theory Tech., vol. 41,

pp. 136-140, 1993.

[7] M. J. Hagmann, R. Calloway, A. Osborn, and K. Foster, "Muscle equivalent phantom materials for 10-100 MHz," IEEE Trans. Microwave Theory Tech., vol. 40, pp. 760-762, 1992.

20
[8] C. Chou, G. Chen, A. Guy, and K. Luk, "Formulas for preparing phantom muscle tissue for

various radiofrequencies," Bioelectromagn., vol. 5, pp. 435-441, 1984.

[9] D. Andreuccetti, M. Bini, and A. Ignesti, "Use of polyacrylamide as a tissue-equivalent material in the microwave range," IEEE Trans. Biomed. Eng., vol. 35, pp. 275-277, 1988.

[10] H. Kato and T. Ishida, "Development of an agar phantom adaptable for simulation of various

tissues in the range 5-40 MHz," Phys. Med. Bio., vol. 32, pp. 221-226, 1987.

[11] Y. Nikawa, M. Chino, and K. Kikuchi, "Soft and dry phantom modeling material using sili- cone rubber with carbon fiber," IEEE Trans. Microwave Theory Tech., vol. 44, pp. 1949-1953,

1996.

[12] C. Marchal, M. Nadi, A. J. Tosser, C. Roussey, and M. L. Gaulard, "Dielectric properties of

gelatine phantoms used for simulations of biological tissues between 10 and 50 MHz," Int. I. Hyperthermia, vol. 5, no. 6, pp. 725-732, 1989.

[13] "Cenelec standard 50361: Basic standard for the measurement of the specific absorption rate

related to human exposure to electromagnetic fields from mobile phones (300 MHz - 3 GHz),"

CENELEC, 2000.

[14] P. S. Hall and Y. Hao, Antennas and propagation for body-centric wireless communications.

Boston: Artech House, 2006.

[15] M. J. Peters, J. G. Stinstra, and M. Hendriks, "Estimation of the electrical conductivity of

human tissue," Electromagn., vol. 21, pp. 545-557, 2001.

[16] C. Gabriel and B. Gestblom, "Microwave absorption in aqueous solutions," Nature, vol. 328,

pp. 145-146, 1987.

[17] M. A. Stuchly and S. S. Stuchly, "Coaxial line reflection methods for measuring dielectric

properties of biological substances at radio and microwave frequencies-A review," IEEE

Trans. Instrum. Meas., vol. IM-29, pp. 176-183, 1980.

[18] C. Gabriel, "Compilation of the dielectric properties of body tissues at RF and microwave

frequencies," Tech. Rep. AL/OE-TR- 1996-0037, Brooks Air Force Base, 1996.

[19] C. Gabriel, S. Gabriel, and E. Corthout, "The dielectric properties of biological tissues: I.

Literature survey," Phys. Med. Biol, vol. 41, pp. 2231-2249, 1996.

21
[20] J. Baker-Jarvis, M. D. Janezic, B. Riddle, C. L. Holloway, N. G. Paulter, and J. E. Blendell,

Dielectric and conductor-loss characterization and measurements on electronic packaging

materials. July 2001. NIST Tech. Note 1520.

[21] J. Baker-Jarvis, M. D. Janezic, J. H. Grosvenor, and R. G. Geyer, Transmission/Reflection

and Short-Circuit Line Methods for Measuring Permittivity and Permeability. 1992. NIST

Tech. Note 1355.

A. Appendix: Fundamental Electromagnetic Parameters and

Concepts Used in Material Characterization

In this section, we review the most basic concepts needed to study and interpret dielectric and

magnetic response in materials. For anisotropic and gyrotropic media the most general forms of

the permittivity and permeability are

-j^ \

£ (CO) = (9) I JKe 8y

e^y

/ jJx JKm ^ ?(C0)= -JKnr /Jy . (10)

\ Q Hz)

The off-diagonal elements are due to gyrotropic behavior in an applied magnetic field. In the time domain, material response can be obtained by analyzing the response to a pulse or impulse. The most general causal linear relationship between the displacement and electric fields

is D(r,r) = 8oE(r,0+/ / (x) •E(r,r-T)Jx, (11)

«—

»

where / is the impulse-response function and D = EqE + P. The permittivity is defined in terms of

the Fourier transform of the impulse-response function, e(co) = 8o(l + ^[/]((o)). An analogous

equation can be written between the induction and magnetic fields. From Eq. (11), for isotropic

linear media, e*(co) = eroo + Xr(w) = 8'^(co) — 78^'(o)), (8^00 is the relative optical-limit of the relative

permittivity.

Electric and magnetic fields are attenuated as they travel through lossy materials. The planewave attenuation coefficient in an infinite medium is denoted by the quantity oc and the phase by

p. The propagation coefficient is y = a + 7P = jk -^ jcOy/ejii. For waves in a guided structure, 7 =

22
jy/k^ — k^, where kc = (x)c/c = 2n/Xc is the cutoff wave number, with k = (n^/e'/j'/c. Attenuation

is given by

0)

a = y^e^Y ((tan 6(/ tan 5„j— 1)2 + (tan 5j + tan 5^)2) ' +tan6^tan6w - 1. V2c

(12)

We approximate this for dielectric materials as

-^-y^^M+tan'Srf-l. (13)

V2c

a

For energy considerations a must always be positive. In low-loss dielectric media, tanj5 <C 1 and

a reduces in the limit to a —> coy^e'^/v'^ tan 6^/2c. The phase coefficient p is given by

P = ±-^x/eXv ((tan5^tan5^- 1)2 + (tan5rf + tan6^)2)^/^- (tan5^tan5^- 1).

\/2c

Note that at cutoff, P is a function only of the loss factors. In dielectric media P

reduces to

(14)

p = ±-^V^\/\/l+tan26^ + l. (15)

v2c

The imaginary part of the propagation coefficient defines the phase of an electromagnetic wave and

is related to the refractive index n = ± y^i^. In normal dielectrics the positive square root is taken

in Eq. (14). The wave impedance for a transverse electric and magnetic mode (TEM) is y/p/^;

for a transverse electric mode (TE) is jodjj/y; and for a transverse magnetic mode (TM) is y/y'coe.

As a consequence of conservation of energy, a must be positive. Below cutoff the propagation

coefficient becomes y = y/k^ — k^, because a factor of j is factored out from under the square root. The wavelength in a material is influenced by the permittivity; for example, for a TEM mode,

The skin depth, the distance a plane wave travels such that its amplitude decays to 1 /e of its initial amplitude, is related to the attenuation coefficient by 5^ = i/a. Due to losses, the wave amplitude decays as |E| <== exp (— az). The power in a plane wave, E{z, t) = Eq exp (—az) exp {j{(iit — Pz)),

attenuates as F oc exp(— 2az). The surface impedance in ohms of a conducting material is Z^ =

(1 + /)a6j. In metals, where the conductivity is large, the skin depth reduces to

(16)

y^nf/JOlil'.Gdc

'

where a^^ is the dc conductivity and / is the frequency. We see that the frequency, conductivity,

and permeability of the material determine the skin depth in metals. The surface resistance for

23
highly lossy materials is

^.

' /«. (17,

When the conductors on a substrate are very thin, the fields can penetrate through the conductors

into the substrate. This increases the resistance because the field is in both the metal and the

dielectric. As a consequence of the skin depth, the internal inductance decreases with increasing

frequency, whereas the surface resistance Rs of many metals increases with frequency in proportion

toVJ.

Some materials exhibit ionic conductivity, so that when a static (dc) electric field is applied, a current is induced. This behavior is modeled by the dc conductivity a^c, which produces a low-frequency loss (oc l/w) in addition to polarization loss (£^')- In some materials, such as semiconductors and disordered solids, the conductivity is complex and depends on frequency. This is because the free charge is partially bound and moves by tunneling through potential wells or hops

from well to well.

The complex power flux is summarized by the complex Poynting vector Sc = (l/2)(E(r, co) x

H*(r, co)). The real part of Sc represents dissipation and is the time average over a complete cycle

of the time-domain Poynting vector S{r,t) = E(r,/) x H(r,f). The imaginary part of Sc relates to

the difference between the electric and magnetic stored energy, and when averaged over one cycle

it vanishes.

24
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