### Clothianidin Dietary Exposure and Risk Assessment 

## UNITED STA

**TES ENVIRONMENTA L PROTECTION A** **GENCY**

**MEMORANDUM Date:**  26 September 2012 **SUBJECT:** Clothianidin

– Acute and Chronic Dietary Exposure and Risk Estimates for

Requested Amended Registration on Peppers and New Uses on Strawberry, Citrus, Pistachio, and Tea. PC Code: 044309 Decision No.: 455249 Petition No.: 1E7923 Risk Assessment T ype: Dietary T XR No.: NA MRID No.: NA


## FROM: Michael A. Doherty, Ph.D., Chemist

Risk Assessment Branch II Health Effects Division (7509P) **THROUGH:** David Hrdy, Branch Chief (acting), RAB I

Jennifer R. Tyler, Chemist Dietary Exposure Science Advisory Council (DESAC) Christina Swartz, Branch Chief Risk Assessment Branch II Health Effects Division (7509P) **TO:** Marianne Lewis/Venus Eagle (RM 01)

Insecticide/Rodenticide Registration Division Barbara Madden Risk Integration, Minor Use, and Emergency Response Branch Registration Division (7505P)

Dietary Exposure and Risk Assessment DP Number:

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## UNITED STA

**TES ENVIRONMENTA L PROTECTION A** **GENCY WA** **SHINGTON, D.C. 20460 OFFICE OF CHEMICAL SAFETY AND**  **POLLUTION PREVENTION**



## September 2012

Acute and Chronic Dietary Exposure and Risk Estimates for Amended Registration on Peppers and New Uses on Strawberry, Citrus, Pistachio, and Tea. DP Barcode: D 397690

455249 Registration No s . : 59639 1E7923 , 2F8008 Regulatory Action: Amended Registration and New Section 3 Registrations Risk Assessment T ype: Dietary Case No.: 7620 CAS No.: 210880
- 92
- 5 40 CFR: §180. 586


## Michael A. Doherty, Ph.D., Chemist Risk Assessment Branch II Health Effects Division (7509P) David Hrdy, Branch Chief (acting), RAB I Jennifer R. Tyler, Chemist Dietary Exposure Science Advisory Council (DESAC) Christina Swartz, Branch Chief Risk Assessment Branch II Health Effects Division (7509P) Marianne Lewis/Venus Eagle (RM 01) Insecticide/Rodenticide Branch

Division (7505P)
Risk Integration, Minor Use, and Emergency Response Branch Registration Division (7505P) DP Number: D397690 

## UNITED STA

**TES ENVIRONMENTA L PROTECTION A** **GENCY**

**OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION** 



## Acute and Chronic Dietary Exposure and Risk Estimates for Amended Registration on Peppers and New Uses on Strawberry,

59639
- 150, 59639
- 152 Amended Registration and New Section 3 Registrations

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

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## Executive Summary Acute and chronic aggregate dietary (food + drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM

- FCID) Version 3.16 , which uses food consumption data from the U.S. Department of Agriculture’s National Health and Nutrition Examination Survey , What We Eat in America, (NHANES/WWEIA). This dietary survey was conducted from 2003 to 2008. The anal ys es were conducted in support of a human health risk assessment of the proposed new Section 3 registrations on strawberry , citrus (Crop Group 10

- 10), pistachio, and tea as well as proposed a requested increase in the tolerance for residues in/on Crop Subgroup 8

- 10B due to a label amendment to shorten the pre

- harvest interval

. The acute and chronic assessments are based on the screening

- level input assumptions, including tolerance

- level residues, 100% crop treated, and high

- end estimates of residues in drinking water based on estimated concentrations of clothianidin in rice paddy water
. These inputs resulted in risk estimates that are, at most, 2 8 % of the population

- adjusted dose for all population subgroups for both the acute and chronic assessments ; the maximum risk estimate is for children 1

- 2 y ears of age. All dietary

risk estimat es are below HED’s level of concern. **I. Introduction** Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., th e dose that HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncert aint y or safet y factors. For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. HED is generall y concerned when estimated cancer risk exceeds one in one million. References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21

- JUN
- 2000, web link: http://www.epa.gov/fedrgstr/EPA

PEST/2000/July

/Day

- 12/6061.pd f; or see SOP 99.6 (20

- AUG
- 1999). The most recent dietary

risk assessment for clothianidin was conducted b y M. Dohert y ( 1 Feb 2012 , D 395798 ). This is the first assessment conducted using the NHANES/WWEIA consumption database. **II. Residue Information** T he acute and chronic assessments rel y on tolerance

- level residues (40 CFR 180.586) for all crops with registered and/or requested clothianidin uses (Table 1) . For crops except leafy vegetables, the residue of concern for risk assessment purposes is the pa rent compound. For root crops and leafy

vegetables, the residues of concern are the parent compound and the TMG metabolite. Field trial data show no detectable residues of TMG in root crops and that TMG does not exceed 10% of the parent compound residue level in leafy vegetables. A factor of 1.1

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

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## (entered into the model as Adjustment Factor 1) has been incorporated into the assessment for leafy vegetables to account for the presence of TMG. For livestock commodities, the residues of concern are the parent compound as well as the metabolites TZU, TZG, TZNG, ATMG

py ruvate, and ATG

- acetate. Milk is currently the only livestock

- derived commodity with a tolerance for clothianidin. A factor of 1.5, which is based on metabolism data, has been incorporated into the assessment to account for the residues of concern in milk. There are a number of crops for which uses of both clothianidin and thiamethoxam have been registered. The labels for the various end

- use products containing these active ingredients prohibi t the application of both active ingredients to the same crop during a growing cy cle. Due to that restriction and the assumption of 100% crop treated, a single value reflecting the greatest clothianidin residue from either active ingredient has been used for crops listed for use with both active ingredients (versus combined estimates from clothianidin and from thiamethoxam). Generally , this assessment uses the established or recommended clothianidin tolerance for crops having tolerances for both compounds . For foods with thiamethoxam tolerances but without clothianidin tolerances, maximum residues of clothianidin observed in thiamethoxam residue trials have been used in these assessments. These include meats, meat b y - products, artichoke, tropical fruits, coffee, hop, and mint. Orange processing stud y data show that clothianidin does not concentrate in citrus oil or juice. Relative to the whole fruit, there is a modest increase in residues in pulp (1.8X). These empirical processing factors , as well as those derived previously , have been included in these anal ys es. Complete listings of the residue estimates, metabolite factors, and processing factors used in these anal ys es may

be found in Attachment 1. The USDA’s Pesticide Data Program included clothianidin as a target analyte in its 2008

- 2010 survey of pesticide residues in catfish. Over the course of those three ye ars, there were no detectable residues of clothianidin in any of the 1479 samples of cat fish. While there is no specific expectation of clothianidin residues in fish as a result of the compound’s agricultural uses, there is a use in food handling establishments; therefore, fish have been included as a source of clothianidin exposure in these analy ses. Table 1. Summary of Recommended Tolerance Levels for the Proposed New Uses and Label Amendments for Clothianidin. Commodity Recommended Tolerance, ppm Comments Pistachio 0.01 Translated from existing tree nut listing Straw berry 1.50 From acceptable field trial data Fruit, citrus, group 10

- 10 0. 6 0 From acceptable field trial data Tea, fresh 70 From acceptable field trial data Vegetables, fruiting, group 8

- 10, except pepper/eggplant subgroup 8

- 10B 0.20 From existing Group 8 listing Vegetables, fruiting, pepper/eggplant subgroup 8

- 10B 0.80 From acceptable field trial data 

## III. Percent Crop Treated Information HED has assumed 100% crop treated for these analy ses.

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

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## IV. Drinking Water Data The Environmental Fate and Effects Division (EFED) has supplied HED with Tier I estimated drinking water concentrations (EDWC) for clothianidin in surface water resulting from foliar application to rice (R. Baris, 15 September 2011, D393235)

. EFED used the Tier I Rice Model (v 1.0) as a screening model to calculate the surface water EDWC resulting from a single foliar application of clothianidin to a flooded field (as proposed on the label)

. This concentration represents the estimated concentr ation that would be expected in the release water downstream of the treated rice paddy . FIRST ( FQPA Index Reservoir Screening Tool, version 1. 1 , 0 1 /01/0 7) was used to calculate the surface water EDWC resulting from a single foliar application to leafy veg etables. These concentrations are presented in Table 2
. Table 2 . Tier I EDWCs for drinking water risk assessment based on the proposed clothianidin use on rice and leafy vegetables Use (application rate, lbs a.i./A) Model Ac ute Chronic Surface water drinking water sources, dow nstream of rice paddy (0.084 lb a.i./A) Tier I Rice Model (v1.0) 72 ppb <72 ppb 

## The EDWC of 72 ppb has been used to account for residues of clothianidin in both the acute and chronic dietary

risk assessments. This is the same EDWC that was used in the most recent dietary assessment. EFED has confirmed that it is the appropriate value to use in this assessment (e

- mail from R. Baris ; 16 July 2012, 3:12:46 pm). **V. DEEM -**  **FCID Program and Consumption Information** Clothianidin acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM

- FCID, Version 3.16, which incorporates consumption data from USDA’s NHANES/WWEIA. This dietary survey was conducted from 2003 to 2008. The data are based on the reported consumption of more than 20,000 individuals over two non

- consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA

- defined food commodities ( e.g., apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. However, for acute exposure assessment, consumption data are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account di etary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 y ear old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 2 0
- 49, females 13

- 49, and adults 50+ years old. For a chronic dietary

exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

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## estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. For an acute exposure assessment, individual one

- day food consumption data are used on an individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by

a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in mul tiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., onl y those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for anal ys es performed at all levels of refinement. However, for det erministic assessments, any significant differences in user vs. per capita exposure and risk are specificall y identified and noted in the risk assessment. **VI. Toxicological Information** The doses and endpoints for human health dietary risk assessments are summarized in Table 3
. Table 3 . Clothianidin Toxicological Doses and Endpoints for Use in Human Health Dietary Risk Assessments Exposure/ Scenario Point of

Departure Uncertainty/

FQPA Safety Factors Level of

Concern for Risk Assessment Study and Toxicological Effects
Ac ute Dietary Fem ales age 13
- 49 NOAEL =

25 mg/kg/day UF A 

### = 10x

UF H 

### = 10x SF FQPA 

### =1 aRfD =

0.25 mg/kg/day aPAD = 0.25 mg/kg/day **Rabbit developmental study**

LOAEL = 75 mg/kg/day based on increased litter incidence of a missing lobe of the lung Ac ute Dietary General population NOAEL =

25 mg/kg/day UF A 

### = 10x

UF H 

### = 10x SF FQPA 

### = 1 aRfD =

0.25 mg/kg/day aPAD = 0.25 mg/kg/day **Special neurotoxicity/pharmacol**

**study in mice** LOAEL = 50 mg/kg/day based on transient signs of decreased spontaneous motor activity, tremors and deep respirations Chronic Dietary All populations including infants and children NOAEL=

9.8 mg/kg/day UF A 

### = 10x

UF H 

### = 10x SF FQPA 

### =1 cRfD=0.098

mg/kg/day cPAD=0.098 mg/kg/day **2 -**  **Generation reproduction study**

LOAEL = 31.2 mg/kg/day based on decreased body weight gains and delayed sexual maturation, decreased absolute thymus weights in F1 pups and increased stillbirths in both generations Cancer **“Not Likely to be Carcinogenic to Hum ans**  ” Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no ob served adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A 

### = extrapolation from animal to human (interspecies). UF H 

### = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population

- adjusted dose (a = acute, c = chronic). RfD = reference dose.

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

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## VII. Results/Discussion F or acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM

- FCID anal ys es estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 4 are for the general U.S. Population, all infants (<1 y ear old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, females 13

- 49 , adults 20

- 49, and adults 50

- 99 y ears. All estimates are below HED’s level of concern. Table 4 . Summary of Acute and Chronic Dietary Exposure and Risk Estimates for Clothianidin. Population Subgroup Ac ute (95 th 

### Percentile) Chronic Exposure, mg/kg/day % aPAD Exposure, mg/kg/day % cPAD Total US Population 0.020913 8 0.007458 8 All Infants 0.051461 21 0.016683 17 **Children 1 -**  **2 years old 0.069586**  **28 0.027256**  **28** Children 3

- 5 y ears old 0.048260 19 0.018444 19 Children 6

- 12 y ears old 0.024264 10 0.009165 9 Youth 13

- 19 y ears old 0.014341 6 0.005346 6 Adults 20

- 49 y ears old 0.015090 6 0.005822 6 Adults 50

- 99 y ears old 0.014403 6 0.006109 6 Fem ale 13

- 49 y ears old 0.015390 6 0.005974 6 The population subgroup(s) with the highest exposure/risk estimates are shown in **bold**
. 

## VIII. **Characterization of Inputs/Outputs** The acute and chronic assessments are based on highl y conservative, health

- protective assumptions regarding residue levels in food and percentage of crops treated. L ikewise, the estimated concentration in drinking water is highly conservative, especially given that it represents residues in rice padd y tail water and no adjustment was made to take into account the portion of the watershed that would be cropped to rice. The anal ys es resulting from these assumptions should be considered screening

- level analy ses that likely overestimate actual dietary exposure to clothianidin. **IX. Conclusions** There are no dietary

exposure or ris k considerations that would preclude making the label amendment shortening the PHI for Crop Subgroup 8

- 10B, registering the clothianidin end

- use products as requested, and establishing tolerances commensurate with those registration actions. **X. List of A ttachments**  1. Inputs for the Acute and Chronic Dietary Exposure Assessment of Clothianidin. 2. Summary

of the Results of the Acute Dietary Exposure Assessment of Clothianidin. 3. Summary

of the Results of the Chronic Dietary Exposure Assessment of Clothianidin.

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

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## Attachment 1. Inputs for the Acute and Chronic Dietary Exposure Assessment of Clothianidin.
Filename: C: \ Documents and Settings \ mdoherty \ My Documents \ Chemistry Reviews \ !DEEM Runs \ Clothianidin \ 2012 \ 044309 (2012).R08 Chemical: Clothianidin RfD( Chronic): .098 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 09

- 18
- 2012/10:16:01 Program ver. 3.16, 03

- 08
- d

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- -- -- ------------------------------- ---------- ------ ------ ------- 9500001000 O Acerola 0.005000 1.000 1.000 From FHE Thiamethoxam 9500006000 O Amaranth, grain 0.005000 1.000 1.000 From FHE Th iamethoxam 9500016000 O Artichoke, globe 0.029000 1.000 1.000 From thiamethoxam 9500019000 O Asparagus 0.005000 1.000 1.000 From FHE Thiamethoxam 9500020000 O Avocado 0. 020000 1.000 1.000 From thiamethoxam 9500022000 O Bamboo, shoots 0.005000 1.000 1.000 From FHE Thiamethoxam 9500023000 O Banana 0.005000 1.000 1.000 From FHE Thiamethoxam 9500024000 O Ban ana, dried 0.005000 3.900 1.000 From FHE Thiamethoxam 9500024001 O Banana, dried
- babyfood 0.005000 3.900 1.000 From FHE Thiamethoxam 9500023001 O Banana
- babyfood 0.005000 1.000 1.000 Fro m FHE Thiamethoxam 9500054000 O Belgium endive 0.005000 1.000 1.000 From FHE Thiamethoxam 9500060000 O Breadfruit 0.005000 1.000 1.000 From FHE Thiamethoxam 9500073000 O Cactus 0.005000 1.000 1.000 From FHE Thiamethoxam 9500074000 O Canistel 0.005000 1.000 1.000 From FHE Thiamethoxam 9500077000 O Carob 0.005000 1.000 1.000 From FHE Thiamethoxam 950 0089000 O Cherimoya 0.005000 1.000 1.000 From FHE Thiamethoxam 9500109000 O Cocoa bean, chocolate 0.005000 1.000 1.000 From FHE Thiamethoxam 9500110000 O Cocoa bean, powder 0.005000 1 .000 1.000 From FHE Thiamethoxam 9500112000 O Coconut, dried 0.005000 2.100 1.000 From FHE Thiamethoxam 9500111000 O Coconut, meat 0.005000 1.000 1.000 From FHE Thiamethoxam 9500111001 O Coconut, meat - babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 9500113000 O Coconut, milk 0.005000 1.000 1.000 From FHE Thiamethoxam 9500114000 O Coconut, oil 0.005000 1.000 1.000 From FHE Thiamethoxam 9500116000 O Coffee, instant 0.040000 1.000 1.000 From thiamethoxam 9500115000 O Coffee, roasted bean 0.040000 1.000 1.000 From thiamethoxam 9500141000 O Date 0.005000 1.000 1.000 From FHE Thiamethoxam 9500151000 O Feijoa 0.005000 1.000 1.000 From FHE Thiamethoxam 9500153000 O Fig 0.050000 1.000 1.000 9500154000 O Fig, dried 0.050000 1.000 1.000 9500177000 O Grape, leaves 0.600000 1.000 1.000 9500178000 O Grape, raisin 0.600000 2.500 1.000 95001830 00 O Guava 0.005000 1.000 1.000 From FHE Thiamethoxam 9500183001 O Guava
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 9500186000 O Honey 0.005000 1.000 1.000 From FHE Thiamethoxam 9500186001 O Honey
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 9500188000 O Hop 0.028000 1.000 1.000 From thiamethoxam 9500193000 O Jackfruit 0.005000 1.000 1.000 From FHE Thiamethoxam 9500209000 O Longan 0.005000 1.000 1.000 From FHE Thiamethoxam 9500211000 O Lychee 0.005000 1.000 1.000 From FHE Thiametho xam 9500212000 O Lychee, dried 0.005000 1.850 1.000 From FHE Thiamethoxam 9500214000 O Mamey apple 0.005000 1.000 1.000 From FHE Thiamethoxam 9500215000 O Mango 0.020 000 1.000 1.000 From thiamethoxam 9500216000 O Mango, dried 0.020000 1.000 1.000 From thiamethoxam 9500217000 O Mango, juice 0.020000 1.000 1.000 From thiamethoxam 9500217001 O Mango, juice
- b abyfood 0.020000 1.000 1.000 From thiamethoxam 9500215001 O Mango
- babyfood 0.020000 1.000 1.000 From thiamethoxam 9500219000 O Maple syrup 0.005000 1.000 1.000 From FHE Thiamethoxam 9500218000 O Maple, sugar 0.005000 1.000 1.000 From FHE Thiamethoxam 9500235000 O Olive 0.005000 1.000 1.000 From FHE Thiamethoxam 9500236000 O Olive, oil 0.005000 1.000 1.000 From FHE Thiamethoxam 9500243000 O Palm heart, leaves 0.005000 1.000 1.000 From FHE Thiamethoxam 9500244000 O Palm, oil 0.005000 1.000 1.000 From FHE Thiamethoxam 9500244001 O Palm, oil
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 9500245000 O Papaya 0.020000 1.000 1.000 From thiamethoxam 9500246000 O Papaya, dried 0.020000 1.800 1.000 From thiam ethoxam 9500247000 O Papaya, juice 0.020000 1.500 1.000 From thiamethoxam 9500245001 O Papaya
- babyfood 0.020000 1.000 1.000 From thiamethoxam 9500252000 O Passionfruit 0.005000 1.000 1.000 From FHE Thiamethoxam

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 8 of 17 9500253000 O Passionfruit, juice 0.005000 1.000 1.000 From FHE Thiamethoxam 9500253001 O Passionfruit, juice
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 9500252001 O Passio nfruit
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 9500254000 O Pawpaw 0.005000 1.000 1.000 From FHE Thiamethoxam 9500263000 O Peanut 0.010000 1.000 1.000 95002 64000 O Peanut, butter 0.010000 1.890 1.000 9500265000 O Peanut, oil 0.010000 0.310 1.000 PF for thiamethoxam 9500275000 O Peppermint 0.128000 1.000 1.000 From thiamet hoxam 9500276000 O Peppermint, oil 0.128000 1.000 1.000 From thiamethoxam 9500277000 O Persimmon 0.005000 1.000 1.000 From FHE Thiamethoxam 9500279000 O Pineapple 0.00500 0 1.000 1.000 From FHE Thiamethoxam 9500280000 O Pineapple, dried 0.005000 5.000 1.000 From FHE Thiamethoxam 9500281000 O Pineapple, juice 0.005000 1.700 1.000 From FHE Thiamethoxam 9500281001 O Pine apple, juice
- babyfood 0.005000 1.700 1.000 From FHE Thiamethoxam 9500279001 O Pineapple
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 9500283000 O Plantain 0.005000 1.000 1.000 From FHE Thiamethoxam 9500284000 O Plantain, dried 0.005000 3.900 1.000 From FHE Thiamethoxam 9500289000 O Pomegranate 0.200000 1.000 1.000 From thiamethoxam 9500306000 O Psyllium, seed 0.005000 1.000 1.000 From FHE Thiamethoxam 9500311000 O Quinoa, grain 0.005000 1.000 1.000 From FHE Thiamethoxam 9500333000 O Sapote, Mamey 0.020000 1.000 1.000 From thiamethoxam 9500335000 O Seaweed 0.005000 1.000 1.000 From FHE Thiamethoxam 9500335001 O Seaweed
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 9500346000 O Soursop 0.005000 1.000 1.000 From FHE Thiamethoxam 9500351000 O Spanish lime 0.005000 1.000 1.000 From FHE Thiamethoxam 9500352000 O Spearmint 0.128000 1.000 1.000 From thiamethoxam 9500353000 O Spearmint, oil 0.128000 1.000 1.000 From thiamethoxam 9500358000 O Starfruit 0.005000 1.000 1.000 From FHE Thiamethoxam 9500361000 O Sugar apple 0.005000 1.000 1.000 From FHE Thiamethoxam 9 500363000 O Sugarcane, molasses 0.005000 1.000 1.000 From FHE Thiamethoxam 9500363001 O Sugarcane, molasses
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 9500362000 O Sugarcane, sugar 0.005000 1.000 1.000 From FHE Thiamethoxam 9500362001 O Sugarcane, sugar
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 9500368000 O Tamarind 0.005000 1.000 1.000 From FHE Thiamethoxam 9500372000 O Tea, dr ied 70.000000 1.000 1.000 1E7923 (2012) 9500373000 O Tea, instant 70.000000 1.000 1.000 1E7923 (2012) 9500390000 O Vinegar 0.005000 1.000 1.000 From FHE Thiamethoxam 9500397000 O Water chestnut 0.005000 1.000 1.000 From FHE Thiamethoxam 9500398000 O Watercress 0.005000 1.000 1.000 From FHE Thiamethoxam 0103015000 1CD Arrowroot, flour 0.300000 1.000 1.000 0103015001 1CD Arrowroot, flour
- babyfood 0.300000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.300000 1.000 1.000 0101050000 1AB Beet, garden, roots 0.800000 1.000 1.000 0101050 001 1AB Beet, garden, roots
- babyfood 0.800000 1.000 1.000 0101052000 1A Beet, sugar 0.020000 1.000 1.000 0101053000 1A Beet, sugar, molasses 0.050000 1.000 1.000 0101053001 1A Beet, sugar, mol asses - babyfood 0.050000 1.000 1.000 0101052001 1A Beet, sugar
- babyfood 0.020000 1.000 1.000 0101067000 1AB Burdock 0.800000 1.000 1.000 0101078000 1AB Carrot 0.8000 00 1.000 1.000 0101079000 1AB Carrot, juice 0.800000 1.000 1.000 0101078001 1AB Carrot
- babyfood 0.800000 1.000 1.000 0103082000 1CD Cassava 0.300000 1.000 1.000 0103082001 1CD Cassava
- babyfood 0.300000 1.000 1.000 0101084000 1AB Celeriac 0.800000 1.000 1.000 0101100000 1AB Chicory, roots 0.800000 1.000 1.000 0103139000 1CD Dasheen, corm 0.300000 1.000 1.000 0103166000 1CD Ginger 0.300000 1.000 1.000 0103167000 1CD Ginger, dried 0.300000 1.000 1.000 0103166001 1CD Ginger
- babyfood 0.300000 1.000 1.000 0101168000 1AB Ginseng, dried 0.800000 1.000 1.000 0101190000 1AB Horseradish 0.800000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.800000 1.000 1.000 0101251000 1AB Parsnip 0.800000 1.000 1.000 0101251001 1AB Parsnip
- babyfood 0.800000 1.000 1.000 0103296000 1C Potato, chips 0.600000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 1.500000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 1.500000 6.500 1.000 0103298000 1C Potato, flour 0.300000 1.000 1.000 0103298001 1C Potato, flour
- babyfood 0.300000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.300000 1.000 1.000

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 9 of 17 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.300000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.300000 1.000 1.00 0 0103299001 1C Potato, tuber, w/peel

- babyfood 0.300000 1.000 1.000 0101316000 1AB Radish, Oriental, roots 0.800000 1.000 1.000 0101314000 1AB Radish, roots 0.800000 1.000 1.000 0101327000 1AB Rutab aga 0.800000 1.000 1.000 0101331000 1AB Salsify, roots 0.800000 1.000 1.000 0103366000 1CD Sweet potato 0.300000 1.000 1.000 0103366001 1CD Sweet potato
- babyfood 0.300000 1.000 1.000 0103371000 1CD Tanier, corm 0.300000 1.000 1.000 0103387000 1CD Turmeric 0.300000 1.000 1.000 0101388000 1AB Turnip, roots 0.800000 1.000 1.000 0103407000 1CD Yam bean 0.300000 1.000 1.000 0103406000 1CD Yam, true 0.300000 1.000 1.000 0200051000 2 Beet, garden, tops 0.600000 1.000 1.000 0200101000 2 C hicory, tops 0.600000 1.000 1.000 0200140000 2 Dasheen, leaves 0.600000 1.000 1.000 0200317000 2 Radish, Oriental, tops 0.600000 1.000 1.000 0200315000 2 Radish, tops 0.600000 1.000 1.000 0200332000 2 Salsify, tops 0.600000 1.000 1.000 0302103000 3B Chive, fresh leaves 0.005000 1.000 1.000 From FHE Thiamethoxam 0301165000 3A Garlic, bulb 0.450000 1.000 1.000 0301165001 3A Garlic, bulb
- babyfood 0.450000 1.000 1.000 0302198000 3B Leek 0.450000 1.000 1.000 0301237000 3A Onion, bulb 0.450000 1.000 1. 000 0301238000 3A Onion, bulb, dried 0.450000 9.000 1.000 0301238001 3A Onion, bulb, dried
- babyfood 0.450000 9.000 1.000 0301237001 3A Onion, bulb
- babyfood 0.450000 1.000 1.000 0302239000 3B Oni on, green 0.450000 1.000 1.000 0302338500 3B Shallot, fresh leaves 0.450000 1.000 1.000 0401005000 4A Amaranth, leafy 3.000000 1.100 1.000 1.1 factor to account for TMG metabolite 040 1018000 4A Arugula 3.000000 1.100 1.000 1.1 factor to account for TMG metabolite 0402076000 4B Cardoon 0.400000 1.000 1.000 From Thiamethoxam 0402085000 4B Celery 0.400000 1.000 1.000 From Thiamethoxam 0402086000 4B Celery, juice 0.400000 1.000 1.000 From Thiamethoxam 0402085001 4B Celery
- babyfood 0.400000 1.000 1.000 From Thiamethoxam 0402087000 4B Celtu ce 0.400000 1.000 1.000 From Thiamethoxam 0401104000 4A Chrysanthemum, garland 3.000000 1.100 1.000 1.1 factor to account for TMG metabolite 0401133000 4A Cress, garden 3.000000 1.1 00 1.000 1.1 factor to account for TMG metabolite 0401134000 4A Cress, upland 3.000000 1.100 1.000 1.1 factor to account for TMG metabolite 0401138000 4A Dandelion, leaves 3.000000 1.100 1.000 1.1 factor to account for TMG metabolite 0401150000 4A Endive 3.000000 1.100 1.000 1.1 factor to account for TMG metabolite 0402152000 4B Fennel, Florence 0.400000 1.000 1.000 From Thiamethoxam 0401204000 4A Lettuce, head 3.000000 1.100 1.000 1.1 factor to account for TMG metabolite 0401205000 4A Lettuce, leaf 3.000000 1.100 1.000 1.1 factor to account for TMG metabolite 0401248000 4A Pars ley, leaves 3.000000 1.100 1.000 1.1 factor to account for TMG metabolite 0401313000 4A Radicchio 3.000000 1.100 1.000 1.1 factor to account for TMG metabolite 0402322000 4B Rhubarb 0.400000 1.000 1.000 From Thiamethoxam 0401355000 4A Spinach 3.000000 1.100 1.000 1.1 factor to account for TMG metabolite 0401355001 4A Spinach
- babyfood 3.000000 1.100 1.000 1.1 fac tor to account for TMG metabolite 0402367000 4B Swiss chard 0.400000 1.000 1.000 From Thiamethoxam 0501061000 5A Broccoli 1.900000 1.000 1.000 0502063000 5B Broccoli raab 1.900000 1.000 1.000 0501062000 5A Broccoli, Chinese 1.900000 1.000 1.000 0501061001 5A Broccoli
- babyfood 1.900000 1.000 1.000 0501064000 5A Brussels sprouts 1.900000 1.000 1.000 0501069000 5A Cabbage 1.900000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 1.900000 1.000 1.000

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 10 of 17 0501072000 5A Cabbage, Chinese, mustard 1.900000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 1.900000 1.000 1.000 0501083000 5A Cauliflower 1.900000 1.000 1.000 0502117000 5B Collards 1.900000 1.000 1.000 0502194000 5B Kale 1.900000 1.000 1.000 0501196000 5A Kohlrabi 1.900000 1.000 1.000 0502229000 5B Mustard greens 1.900000 1.000 1.000 0502318000 5B Rape greens 1.900000 1.000 1.000 0502389000 5B Turnip, greens 1.900000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.010000 1.000 1.000 From Thiamethoxam 0603030000 6C Bean, black, seed 0.010000 1.000 1.000 From Thiamethoxam 0603032000 6C Bean, broad, seed 0.010000 1.000 1.000 From Thiamethoxam 0602031000 6B Bean, broad, succulent 0.010000 1.000 1.000 From Thiamethoxam 0603034000 6C Bean, cowpea, seed 0.010000 1.000 1.000 From Thiamethoxam 0602033000 6B Bean, cowpea, succulent 0.010000 1.000 1.000 From Thiamethoxam 0603036000 6C Bean, kidney, seed 0.010000 1.000 1.000 From Thiamethoxam 0603038000 6C Bean, lima, seed 0.010000 1.000 1.000 From Thiamethoxam 0602037000 6B Bean, lima, succulent 0.010000 1.000 1.000 From Thiamethoxam 0603039000 6C Bean, mung, seed 0.010000 1.000 1.000 From Thiametho xam 0603040000 6C Bean, navy, seed 0.010000 1.000 1.000 From Thiamethoxam 0603041000 6C Bean, pink, seed 0.010000 1.000 1.000 From Thiamethoxam 0603042000 6C Bean, pinto, seed 0.010000 1. 000 1.000 From Thiamethoxam 0601043000 6A Bean, snap, succulent 0.010000 1.000 1.000 From Thiamethoxam 0601043001 6A Bean, snap, succulent
- babyfood 0.010000 1.000 1.000 From Thiamethoxam 0603099000 6C Chickpea, flour 0.010000 1.000 1.000 From Thiamethoxam 0603098000 6C Chickpea, seed 0.010000 1.000 1.000 From Thiamethoxam 0603098001 6C Chickpea, seed
- babyfood 0.010000 1.000 1.000 From Thiamethoxam 0603182000 6 C Guar, seed 0.010000 1.000 1.000 From Thiamethoxam 0603182001 6C Guar, seed
- babyfood 0.010000 1.000 1.000 From Thiamethoxam 0603203000 6C Lentil, seed 0.010000 1.000 1.000 From Thiamethoxam 0603256000 6C Pea, dry 0.010000 1.000 1.000 From Thiamethoxam 0603256001 6C Pea, dry
- babyfood 0.010000 1.000 1.000 From Thiamethoxam 0601257000 6A Pea, edible podded, succulent 0.0 10000 1.000 1.000 From Thiamethoxam 0603258000 6C Pea, pigeon, seed 0.010000 1.000 1.000 From Thiamethoxam 0602259000 6B Pea, pigeon, succulent 0.010000 1.000 1.000 From Thiamethoxam 0602255000 6B Pea, succule nt 0.010000 1.000 1.000 From Thiamethoxam 0602255001 6B Pea, succulent
- babyfood 0.010000 1.000 1.000 From Thiamethoxam 0603348000 6C Soybean, flour 0.020000 1.000 1.000 From Thiamethoxam 06 03348001 6C Soybean, flour
- babyfood 0.020000 1.000 1.000 From Thiamethoxam 0600350000 6 Soybean, oil 0.020000 1.000 1.000 From Thiamethoxam 0600350001 6 Soybean, oil
- babyfood 0.020000 1.000 1.000 From Thiamethoxam 0600347000 6 Soybean, seed 0.020000 1.000 1.000 From Thiamethoxam 0600349000 6 Soybean, soy milk 0.020000 1.000 1.000 From Thiamethoxam 0600349001 6 Soybean, soy milk
- babyfood or in 0.020000 1.000 1.000 From Thiamethoxam 0802148000 8BC Eggplant 0.800000 1.000 1.000 Incr. tol. due to PHI change 0802234000 8BC Okra 0.800000 1.000 1.000 Incr. tol. due to PHI ch ange 0802270000 8B Pepper, bell 0.800000 1.000 1.000 Incr. tol. due to PHI change 0802271000 8B Pepper, bell, dried 0.800000 1.000 1.000 Incr. tol. due to PHI change 0802271001 8B Pepper, bell, dried
- babyf ood 0.800000 1.000 1.000 Incr. tol. due to PHI change 0802270001 8B Pepper, bell
- babyfood 0.800000 1.000 1.000 Incr. tol. due to PHI change 0802272000 8BC Pepper, nonbell 0.800000 1.000 1.000 Incr. tol. due to PHI change 0802273000 8BC Pepper, nonbell, dried 0.800000 1.000 1.000 Incr. tol. due to PHI change 0802272001 8BC Pepper, nonbell
- babyfood 0.800000 1.000 1.000 Incr. tol. due to PHI change 0801374000 8A Tomatillo 0.200000 1.000 1.000 0801375000 8A Tomato 0.200000 1.000 1.000 0801380000 8A Tomato, Tree 0.005000 1.000 1.000 From FHE Thiamethoxam 0801378000 8A Tomato, dried 0.200000 14.300 1.000 0801378001 8A Tomato, dried
- babyfood 0.200000 14.300 1.000 0801379000 8A Tomato, juice 0.200000 1.500 1.000 0801376000 8A Tomato, paste 0.2000 00 5.400 1.000 0801376001 8A Tomato, paste
- babyfood 0.200000 5.400 1.000 0801377000 8A Tomato, puree 0.200000 3.300 1.000

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 11 of 17 0801377001 8A Tomato, puree
- babyfood 0.200000 3.300 1.000 08013 75001 8A Tomato
- babyfood 0.200000 1.000 1.000 0902021000 9B Balsam pear 0.060000 1.000 1.000 0901075000 9A Cantaloupe 0.060000 1.000 1.000 0902088000 9B Chayote, fruit 0.060000 1.000 1.000 0902102000 9B Chinese waxgourd 0.060000 1.000 1.000 0902135000 9B Cucumber 0.060000 1.000 1.000 0901187000 9A Honeydew melon 0.060000 1.000 1.000 0902308000 9B Pumpkin 0.060000 1.000 1.000 0902309000 9B Pumpkin, seed 0.060000 1.000 1.000 0902356000 9B Squash, s ummer 0.060000 1.000 1.000 0902356001 9B Squash, summer
- babyfood 0.060000 1.000 1.000 0902357000 9B Squash, winter 0.060000 1.000 1.000 0902357001 9B Squash, winter
- babyfood 0.060000 1.000 1.000 0901399000 9A Watermelon 0.060000 1.000 1.000 0901400000 9A Watermelon, juice 0.060000 1.000 1.000 1001106000 10A Citron 0.600000 1.000 1.000 1E7923 (2012) 1001107000 10A Citrus hybrids 0.600000 1.000 1.000 1E7923 (2012) 1001108000 10A Citrus, oil 0.600000 1.000 1.000 1E7923 (2012) 1003180000 10C Grapefruit 0.60000 0 1.000 1.000 1E7923 (2012) 1003181000 10C Grapefruit, juice 0.600000 1.000 1.000 1E7923 (2012) 1002197000 10B Kumquat 0.600000 1.000 1.000 1E7923 (2012) 1002199000 10B Lemon 0.600000 1.000 1.000 1E7923 (2012) 1002200000 10B Lemon, juice 0.600000 1.000 1.000 1E7923 (2012) 1002200001 10B Lemon, juice
- babyfood 0.600000 1.000 1.000 1E7923 (2012) 1002201000 10B Lemon, p eel 0.600000 1.000 1.000 1E7923 (2012) 1002206000 10B Lime 0.600000 1.000 1.000 1E7923 (2012) 1002207000 10B Lime, juice 0.600000 1.000 1.000 1E7923 (2012) 1002207 001 10B Lime, juice
- babyfood 0.600000 1.000 1.000 1E7923 (2012) 1001240000 10A Orange 0.600000 1.000 1.000 1E7923 (2012) 1001241000 10A Orange, juice 0.600000 1.000 1.000 1E79 23 (2012) 1001241001 10A Orange, juice
- babyfood 0.600000 1.000 1.000 1E7923 (2012) 1001242000 10A Orange, peel 0.600000 1.000 1.000 1E7923 (2012) 1003307000 10C Pummelo 0.600000 1. 000 1.000 1E7923 (2012) 1001369000 10A Tangerine 0.600000 1.000 1.000 1E7923 (2012) 1001370000 10A Tangerine, juice 0.600000 1.000 1.000 1E7923 (2012) 1100009000 11 Apple, dried 1.000000 8.000 1.000 1100009001 11 Apple, dried
- babyfood 1.000000 8.000 1.000 1100007000 11 Apple, fruit with peel 1.000000 1.000 1.000 1100010000 11 Apple, ju ice 1.000000 1.300 1.000 1100010001 11 Apple, juice
- babyfood 1.000000 1.300 1.000 1100008000 11 Apple, peeled fruit 1.000000 1.000 1.000 1100008001 11 Apple, peeled fruit
- babyfood 1.000000 1.000 1.000 1100011000 11 Apple, sauce 1.000000 1.000 1.000 1100011001 11 Apple, sauce
- babyfood 1.000000 1.000 1.000 1100129000 11 Crabapple 1.000000 1.000 1.000 1100210000 11 Loquat 1.000000 1.000 1.000 1100266000 11 Pear 1.000000 1.000 1.000 1100267000 11 Pear, dried 1.000000 6.250 1.000 1100268000 11 Pear, j uice 1.000000 1.000 1.000 1100268001 11 Pear, juice
- babyfood 1.000000 1.000 1.000 1100266001 11 Pear
- babyfood 1.000000 1.000 1.000 1100310000 11 Quince 1.000000 1.000 1.000 1202012000 12B Apricot 0.800000 1.000 1.000 Expected use on whole group 1202013000 12B Apricot, dried 0.800000 6.000 1.000 Expected use on whole group 1202014000 12B Apr icot, juice 0.800000 1.000 1.000 Expected use on whole group 1202014001 12B Apricot, juice
- babyfood 0.800000 1.000 1.000 Expected use on whole group 1202012001 12B Apricot
- babyfood 0.800000 1.000 1.000 Expected use on whole group 1201090000 12A Cherry 0.800000 1.000 1.000 Expected use on whole group 1201091000 12A Cherry, juice 0.800000 1.500 1.000 Expected use on whole group 1201091001 12A Cherry, juice
- babyfood 0.800000 1.500 1.000 Expected use on whole group 1201090001 12A Cherry
- babyfood 0.800000 1.000 1.000 Expected use on whole group

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 12 of 17 1202230000 12B Nectarine 0.800000 1.000 1.000 Expected use on whole group 1202260000 12B Peach 0.800000 1.000 1.000 1202261000 12B Peach, dried 0.800000 7.000 1.000 1202261001 12B Peach, dried
- babyfood 0.800000 7.000 1.000 1202262000 12B Peach, juice 0.800000 1.000 1.000 1202262001 12B Peach, juice
- babyfood 0.800000 1.000 1.000 1202260001 12B Peach
- babyfood 0.800000 1.000 1.000 1203285000 12C Plum 0.800000 1.000 1.000 Expected use on whole group 1203287000 12C Plum, prune, dried 0.800000 5.000 1.000 Expected use on whole group 1203287001 12C Plum, prune, drie d
- babyfood 0.800000 5.000 1.000 Expected use on whole group 1203286000 12C Plum, prune, fresh 0.800000 1.000 1.000 Expected use on whole group 1203286001 12C Plum, prune, fresh
- babyfood 0.800000 1.000 1.000 Expec ted use on whole group 1203288000 12C Plum, prune, juice 0.800000 1.400 1.000 Expected use on whole group 1203288001 12C Plum, prune, juice
- babyfood 0.800000 1.400 1.000 Expected use on whole group 1203285001 12C Plum
- baby food 0.800000 1.000 1.000 Expected use on whole group 1301055000 13A Blackberry 0.040000 1.000 1.000 From Thiamethoxam 1301056000 13A Blackberry, juice 0.040000 1.000 1.000 From Th iamethoxam 1301056001 13A Blackberry, juice
- babyfood 0.040000 1.000 1.000 From Thiamethoxam 1302057000 13B Blueberry 0.050000 1.000 1.000 From Thiamethoxam 1302057001 13B Blueberry
- babyfood 0.0500 00 1.000 1.000 From Thiamethoxam 1301058000 13A Boysenberry 0.040000 1.000 1.000 From Thiamethoxam 1307130000 13G Cranberry 0.010000 1.000 1.000 1307131000 13G Cranberry, dried 0.010000 1.000 1.000 1307132000 13G Cranberry, juice 0.010000 1.100 1.000 1307132001 13G Cranberry, juice
- babyfood 0.010000 1.100 1.000 1307130001 13G Cranberry
- babyfood 0.010000 1.000 1.00 0 1302136000 13B Currant 0.050000 1.000 1.000 From Thiamethoxam 1302137000 13B Currant, dried 0.050000 1.000 1.000 From Thiamethoxam 1302149000 13B Elderberry 0.050000 1. 000 1.000 From Thiamethoxam 1302174000 13B Gooseberry 0.050000 1.000 1.000 From Thiamethoxam 1304175000 13D Grape 0.600000 1.000 1.000 1304176000 13D Grape , juice 0.600000 1.200 1.000 1304176001 13D Grape, juice
- babyfood 0.600000 1.200 1.000 1304179000 13D Grape, wine and sherry 0.600000 1.200 1.000 1302191000 13B Huckleberry 0.050000 1.000 1.000 From Thiamethoxam 1304195000 13D Kiwifruit, fuzzy 0.005000 1.000 1.000 From FHE Thiamethoxam 1301208000 13A Loganberry 0.040000 1.000 1.000 From Thiamethoxam 1303227000 13C Mulberry 0.005000 1.000 1.000 From FHE Thiamethoxam 1301320000 13A Raspberry 0.040000 1.000 1.000 From Thiamethoxam 1301321000 13A Raspberry, juice 0.040000 1.000 1.000 From Thiamethoxam 1301321001 13A Raspberry, juice
- babyfood 0.040000 1.000 1.000 From Thiamethoxam 1301320001 13A Raspberry
- babyfood 0.040000 1.000 1.000 From Thiamethoxam 1307359000 13G Strawberry 1.5 00000 1.000 1.000 1E7923 (2012) 1307360000 13G Strawberry, juice 1.500000 1.000 1.000 1E7923 (2012) 1307360001 13G Strawberry, juice
- babyfood 1.500000 1.000 1.000 1E7923 (2012) 1307359001 13G Strawberry
- babyfood 1.500000 1.000 1.000 1E7923 (2012) 1400003000 14 Almond 0.010000 1.000 1.000 1400004000 14 Almond, oil 0.010000 1.000 1.000 1400004001 14 Almond, oil
- babyfood 0.010000 1.000 1.000 1400003001 14 Almond
- babyfood 0.010000 1.000 1.000 1400059000 14 Brazil nut 0.010000 1.000 1.000 1400068000 14 Butternut 0.010000 1.000 1.00 0 1400081000 14 Cashew 0.010000 1.000 1.000 1400092000 14 Chestnut 0.010000 1.000 1.000 1400155000 14 Hazelnut 0.010000 1.000 1.000 1400156000 14 Hazel nut, oil 0.010000 1.000 1.000 1400185000 14 Hickory nut 0.010000 1.000 1.000 1400213000 14 Macadamia nut 0.010000 1.000 1.000 1400269000 14 Pecan 0.010000 1.000 1.000 1400278000 14 Pine nut 0.005000 1.000 1.000 From FHE Thiamethoxam 1400282000 14 Pistachio 0.010000 1.000 1.000 1400391000 14 Walnut 0.010000 1.000 1.000

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 13 of 17 1500027000 15 Barley, bran 0.020000 1.000 1.000 From thiamethoxam 1500026000 15 Barley, flour 0.020000 1.000 1.000 From thia methoxam 1500026001 15 Barley, flour
- babyfood 0.020000 1.000 1.000 From thiamethoxam 1500025000 15 Barley, pearled barley 0.020000 1.000 1.000 From thiamethoxam 1500025001 15 Barley, pearled barley
- babyfood 0.020000 1.000 1.000 From thiamethoxam 1500065000 15 Buckwheat 0.010000 1.000 1.000 Grain seed treatment 1500066000 15 Buckwheat, flour 0.010000 1.000 1.000 Grain seed treatment 1500122000 15 Corn, field , bran 0.010000 1.000 1.000 1500120000 15 Corn, field, flour 0.010000 1.000 1.000 1500120001 15 Corn, field, flour
- babyfood 0.010000 1.000 1.000 1500121000 15 Corn, field, meal 0 .010000 1.000 1.000 1500121001 15 Corn, field, meal
- babyfood 0.010000 1.000 1.000 1500125000 15 Corn, field, oil 0.010000 1.000 1.000 1500125001 15 Corn, field, oil
- babyfood 0.010000 1.000 1.000 1500123000 15 Corn, field, starch 0.010000 1.000 1.000 1500123001 15 Corn, field, starch
- babyfood 0.010000 1.000 1.000 1500124000 15 Corn, field, syrup 0.010000 1.500 1.000 1500124001 15 Corn, fie ld, syrup
- babyfood 0.010000 1.500 1.000 1500126000 15 Corn, pop 0.010000 1.000 1.000 1500127000 15 Corn, sweet 0.010000 1.000 1.000 1500127001 15 Corn, sweet
- babyfood 0.010000 1.000 1.000 1500226000 15 Millet, grain 0.010000 1.000 1.000 Grain seed treatment 1500231000 15 Oat, bran 0.010000 1.000 1.000 Grain seed treatment 1500232000 15 Oat, flour 0.010000 1.000 1.000 Grain seed treatment 1500232001 15 Oat, flour
- babyfood 0.010000 1.000 1.000 Grain seed treatment 1500233000 15 Oat, groats/rolled oats 0.010000 1.000 1.000 Grain seed treatment 1500233001 15 Oat, groats/rolled oats

- babyfood 0.010000 1.000 1.000 Grain seed treatment 1500326000 15 Rice, bran 0.010000 1.000 1.000 1500326001 15 Rice, bran
- babyfood 0.010000 1.000 1.000 1500324000 15 Rice, brown 0.010000 1.000 1.000 1500324001 15 Rice, brown
- babyfood 0.010000 1.000 1.000 1500325000 15 Rice, flour 0.010000 1.000 1.000 1500325001 15 Rice, flo ur - babyfood 0.010000 1.000 1.000 1500323000 15 Rice, white 0.010000 1.000 1.000 1500323001 15 Rice, white
- babyfood 0.010000 1.000 1.000 1500329000 15 Rye, flour 0.010000 1.000 1.000 Grain seed treatment 1500328000 15 Rye, grain 0.010000 1.000 1.000 Grain seed treatment 1500344000 15 Sorghum, grain 0.010000 1.000 1.000 1500345000 15 Sorghum, syrup 0.010000 1.000 1.000 1500381000 15 Triticale, flour 0.010000 1.000 1.000 Grain seed treatment 1500381001 15 Triticale, flour
- babyfood 0.010000 1.000 1.000 Grain seed treatment 1500404000 15 Whea t, bran 0.010000 1.000 1.000 1500402000 15 Wheat, flour 0.010000 1.000 1.000 1500402001 15 Wheat, flour
- babyfood 0.010000 1.000 1.000 1500403000 15 Wheat, germ 0.010000 1.000 1.000 1500401000 15 Wheat, grain 0.010000 1.000 1.000 1500401001 15 Wheat, grain
- babyfood 0.010000 1.000 1.000 1500405000 15 Wild rice 0.010000 1.000 1 .000 Grain seed treatment 1800002000 18 Alfalfa, seed 0.005000 1.000 1.000 From FHE Thiamethoxam 1901029000 19A Basil, dried leaves 0.005000 1.000 1.000 From FHE Thiamethoxam 1901029001 19A Basil, dried leav es - babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 1901028000 19A Basil, fresh leaves 0.005000 1.000 1.000 From FHE Thiamethoxam 1901028001 19A Basil, fresh leaves
- babyfood 0.005000 1.000 1.000 From FHE Thiameth oxam 1901118000 19A Cilantro, leaves 0.005000 1.000 1.000 From FHE Thiamethoxam 1901118001 19A Cilantro, leaves
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 1902105000 19B Cinnamon 0.00 5000 1.000 1.000 From FHE Thiamethoxam 1902105001 19B Cinnamon
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 1902119000 19B Coriander, seed 0.005000 1.000 1.000 From FHE Thiamethoxam 1902119001 19B Coriander, seed
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 1902143000 19B Dill, seed 0.005000 1.000 1.000 From FHE Thiamethoxam 1901144000 19A Dillweed 0.005000 1.000 1.000 From FHE Thiamethoxam 1901184000 19A Herbs, other 0.005000 1.000 1.000 From FHE Thiamethoxam 1901184001 19A Herbs, other
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 1901202000 19A Lemongrass 0.005000 1.000 1.000 From FHE Thiamethoxam 1901220000 19A Marjoram 0.005000 1.000 1.000 From FHE Thiamethoxam 1901220001 19A Marjoram
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 1901249000 19A Parsley, dried leaves 0.005000 1.000 1.000 From FHE Thiamethoxam 1901249001 19A Parsley, dried leaves
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 1902274000 19B Pepper, black and white 0.005000 1.000 1.000 From FHE Thiamethoxam 1902274001 19B Pepper, black and white
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 1901334000 19A Savory 0.005000 1.000 1.000 From FHE Thiamethoxam

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 14 of 17 1902354000 19B Spices , other 0.005000 1.000 1.000 From FHE Thiamethoxam 1902354001 19B Spices, other
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 2003114001 20C Coconut, oil
- babyfood 0.005000 1.000 1.000 From F HE Thiamethoxam 2003128000 20C Cottonseed, oil 0.200000 1.000 1.000 2003128001 20C Cottonseed, oil
- babyfood 0.200000 1.000 1.000 2001163000 20A Flax seed, oil 0.010000 1.000 1.000 200131900 0 20A Rapeseed, oil 0.010000 1.000 1.000 2001319001 20A Rapeseed, oil
- babyfood 0.010000 1.000 1.000 2002330000 20B Safflower, oil 0.010000 1.000 1.000 2002330001 20B Safflower, oil
- bab yfood 0.010000 1.000 1.000 2001337000 20A Sesame, oil 0.005000 1.000 1.000 From FHE Thiamethoxam 2001337001 20A Sesame, oil
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 2001336000 20A S esame, seed 0.005000 1.000 1.000 From FHE Thiamethoxam 2001336001 20A Sesame, seed
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 2002365000 20B Sunflower, oil 0.010000 1.000 1.000 2002365001 20B Sunflower, oil
- babyfood 0.010000 1.000 1.000 2002364000 20B Sunflower, seed 0.010000 1.000 1.000 2100228000 21 Mushroom 0.005000 1.000 1.000 From FHE Thiamethoxam 3100 047000 31 Beef, fat 0.005000 1.000 1.000 From FHE Thiamethoxam 3100047001 31 Beef, fat
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 3100048000 31 Beef, kidney 0.010000 1. 000 1.000 From thiamethoxam 3100049000 31 Beef, liver 0.010000 1.000 1.000 From thiamethoxam 3100049001 31 Beef, liver
- babyfood 0.010000 1.000 1.000 From thiamethoxam 3100044000 31 Beef, meat 0.010000 1.000 1.000 From thiamethoxam 3100046000 31 Beef, meat byproducts 0.010000 1.000 1.000 From thiamethoxam 3100046001 31 Beef, meat byproducts
- babyfood 0.010000 1.000 1.000 From thiamethoxam 3100045000 3 1 Beef, meat, dried 0.010000 1.920 1.000 From thiamethoxam 3100044001 31 Beef, meat
- babyfood 0.010000 1.000 1.000 From thiamethoxam 3200171000 32 Goat, fat 0.005000 1.000 1.000 From FHE Thiamethoxam 3200172000 32 Goat, kidney 0.010000 1.000 1.000 From thiamethoxam 3200173000 32 Goat, liver 0.010000 1.000 1.000 From thiamethoxam 3200169000 32 Goat, meat 0.010000 1.000 1.000 From thiamethoxam 3200170000 32 Goat, meat byproducts 0.010000 1.000 1.000 From thiamethoxam 3300189000 33 Horse, meat 0.010000 1.000 1.000 From thiamethoxam 3400293000 34 Pork, fa t 0.005000 1.000 1.000 From FHE Thiamethoxam 3400293001 34 Pork, fat
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 3400294000 34 Pork, kidney 0.010000 1.000 1.000 From thi amethoxam 3400295000 34 Pork, liver 0.010000 1.000 1.000 From thiamethoxam 3400290000 34 Pork, meat 0.010000 1.000 1.000 From thiamethoxam 3400292000 34 Pork, meat byproducts 0.01000 0 1.000 1.000 From thiamethoxam 3400292001 34 Pork, meat byproducts
- babyfood 0.010000 1.000 1.000 From thiamethoxam 3400290001 34 Pork, meat
- babyfood 0.010000 1.000 1.000 From thiamethoxam 3400291000 34 Pork, skin 0.005000 1.000 1.000 From FHE Thiamethoxam 3500341000 35 Sheep, fat 0.005000 1.000 1.000 From FHE Thiamethoxam 3500341001 35 Sheep, fat
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 3500342000 35 Sheep, kidney 0.010000 1.000 1.000 From thiamethoxam 3500343000 35 Sheep, liver 0.010000 1.000 1.000 From thiamethoxam 3500339000 35 Sheep, meat 0.010000 1.000 1.000 From thiamethoxam 3500340000 35 Sheep, meat byproducts 0.010000 1.000 1.000 From thiamethoxam 3500339001 35 Sheep, meat
- babyfood 0.010000 1.000 1.000 From thiamethoxam 3600222000 36 Mi lk, fat 0.010000 1.500 1.000 1.5 factor to account for metabolites 3600222001 36 Milk, fat
- baby food/infant formu 0.010000 1.500 1.000 1.5 factor to account for metabolites 3600223000 36 Milk, nonfat solids 0.010000 1.500 1.000 1.5 factor to account for metabolites 3600223001 36 Milk, nonfat solids
- baby food/in 0.010000 1.500 1.000 1.5 factor to account for metabolites 3600225001 36 Milk, sugar (lactose)
- baby food/ 0.010000 1.500 1 .000 1.5 factor to account for metabolites 3600224000 36 Milk, water 0.010000 1.500 1.000 1.5 factor to account for metabolites 3600224001 36 Milk, water
- babyfood/infant form 0.010000 1.500 1.000 1.5 factor to accou nt for metabolites 3800221000 38 Meat, game 0.010000 1.000 1.000 From thiamethoxam 3900312000 39 Rabbit, meat 0.010000 1.000 1.000 From thiamethoxam 4000096000 40 Chicken, fat 0.005000 1.000 1.000 From FHE Thiamethoxam 4000096001 40 Chicken, fat
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 4000094000 40 Chicken, liver 0.005000 1.000 1.000 From FHE Thiamethoxam 4000093000 40 Chicken, meat 0.005000 1.000 1.000 From FHE Thiamethoxam 4000095000 40 Chicken, meat byproducts 0.005000 1.000 1.000 From FHE Thiamethoxam

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 15 of 17 4000095001 40 Chicken, meat byproducts
- babyfoo 0.005000 1.000 1. 000 From FHE Thiamethoxam 4000093001 40 Chicken, meat
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 4000097000 40 Chicken, skin 0.005000 1.000 1.000 From FHE Thiamethoxam 4000097001 40 Chicken, skin
- bab yfood 0.005000 1.000 1.000 From FHE Thiamethoxam 5000385000 50 Turkey, fat 0.005000 1.000 1.000 From FHE Thiamethoxam 5000385001 50 Turkey, fat
- babyfood 0.005000 1.000 1.000 From FHE Thiameth oxam 5000383000 50 Turkey, liver 0.005000 1.000 1.000 From FHE Thiamethoxam 5000383001 50 Turkey, liver
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 5000382000 50 Turkey, meat 0.005000 1.000 1.000 From FHE Thiamethoxam 5000384000 50 Turkey, meat byproducts 0.005000 1.000 1.000 From FHE Thiamethoxam 5000384001 50 Turkey, meat byproducts
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 5000382001 50 Turkey, meat
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 5000386000 50 Turkey, skin 0.005000 1.000 1.000 From FHE Thiamethoxam 5000386001 50 Turkey , skin
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 6000304000 60 Poultry, other, fat 0.005000 1.000 1.000 From FHE Thiamethoxam 6000302000 60 Poultry, other, liver 0.005000 1.000 1.000 From F HE Thiamethoxam 6000301000 60 Poultry, other, meat 0.005000 1.000 1.000 From FHE Thiamethoxam 6000303000 60 Poultry, other, meat byproducts 0.005000 1.000 1.000 From FHE Thiamethoxam 6000305000 60 Poultry, other, skin 0.005000 1.000 1.000 From FHE Thiamethoxam 7000146000 70 Egg, white 0.005000 1.000 1.000 From FHE Thiamethoxam 7000146001 70 Egg, white (solids)
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 700014 5000 70 Egg, whole 0.005000 1.000 1.000 From FHE Thiamethoxam 7000145001 70 Egg, whole
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 7000147000 70 Egg, yolk 0.005000 1.00 0 1.000 From FHE Thiamethoxam 7000147001 70 Egg, yolk
- babyfood 0.005000 1.000 1.000 From FHE Thiamethoxam 8000157000 80 Fish
- freshwater finfish 0.005000 1.000 1.000 From FHE Thiamethoxam 8000158000 80 Fish
- freshwa ter finfish, farm ra 0.005000 1.000 1.000 From FHE Thiamethoxam 8000160000 80 Fish
- saltwater finfish, other 0.005000 1.000 1.000 From FHE Thiamethoxam 8000159000 80 Fish
- saltwater finfish, tuna 0.005000 1.000 1.000 From FHE Thi amethoxam 8000161000 80 Fish
- shellfish, crustacean 0.005000 1.000 1.000 From FHE Thiamethoxam 8000162000 80 Fish
- shellfish, mollusc 0.005000 1.000 1.000 From FHE Thiamethoxam 8601000000 86A Water, direct, all sources 0.072000 1.000 1.000 Based on Rice Use 8602000000 86B Water, indirect, all sources 0.072000 1.000 1.000 Based on Rice Use

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 16 of 17 

## Attachment 2. Summary of the Results of the Acute Dietary Exposure Assessment of Clothianidin.
Health Effects Division OPP EPA Ver. 3.16, 03
- 08
- d DEEM - FCID ACUTE Analysis for CLOTHIANIDIN NHANES 2003
- 2008 2
- Day Residue file: 044309 (2012).R08 Adjustment factor #2 NOT used. Analysis Date: 09
- 27
- 2012/10:31 :30 Residue file dated: 09
- 27
- 2012/10:29:09 RAC/FF intake summed over 24 hours Run Comment: ""

=============================================================================== Summary calculations
-- per capita: 95th Percentile 99 th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Total US Population: 0.020913 8.37 0.042688 17.08 0.090403 36.16 All Infants: 0.051461 20.58 0.083284 33.31 0.148482 59.39 Children 1
- 2: 0.069586 27.83 0.112708 45.08 0.191457 76.58 Children 3
- 5: 0.048260 19.30 0.071642 28.66 0.108357 43.34 Children 6
- 12: 0.024264 9.71 0.039843 15.94 0.071398 28.56 Youth 13
- 19: 0.014341 5.74 0.021983 8.79 0.038829 15. 53 Adults 20
- 49: 0.015090 6.04 0.022554 9.02 0.035057 14.02 Adults 50
- 99: 0.014403 5.76 0.020962 8.38 0.029246 11.70 Female 13
- 49: 0.015390 6.16 0.022581 9.03 0.035021 14.01

### Clothianidin Dietary Exposure and Risk Assessment DP Number: D397690

Page 17 of 17 

## Attachment 3. Summary of the Results of the Chronic Dietary Exposure Assessment of Clothianidin.
Health Effects Division OPP EPA Ver. 3.16, 03
- 08
- d DEEM - FCID Chronic analysis for CLOTHIANIDIN NHANES 2003
- 2008 2
- day Residue file name: C: \ Documents and Settings \ mdoherty \ My Documents \ Chemistry Reviews \ !DEEM Runs \ Clothianidin \ 2012 \ 044309 (2012).R08 Adjustment factor #2 NOT used. Analysis Date 09
- 27
- 2012/10:30:23 Residue file dated: 09

- 27
- 2012/10:29:09 Reference dose (RfD, Chronic) = .098 mg/kg bw/day

============================================================================ === Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----- ------------------------------ Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------- ------ Total US Population 0.007458 7.6% Hispanic 0.008116 8.3% Non - Hisp
- White 0.007316 7.5% Non - Hisp
- Black 0.007063 7.2% Non - Hisp
- Other 0.008579 8.8% Nursing Infants 0.009356 9.5% Non - Nursing Infants 0.019955 20.4% Female 13+ PREG 0.006687 6.8% Children 1
- 6 0.020830 21.3% Children 7
- 12 0.008313 8.5% Male 13
- 19 0.005242 5.3% Female 13
- 19/NP 0.005442 5.6% Male 20+ 0.005572 5.7% Female 20+/NP 0.006255 6.4% Seniors 55+ 0.006109 6.2% All Infants 0.016683 17.0% Female 13
- 50 0.005986 6.1% Children 1
- 2 0.027256 27.8% Children 3
- 5 0.018444 18.8% Children 6
- 12 0.009165 9.4% Youth 13
- 19 0.005 346 5.5% Adults 20
- 49 0.005822 5.9% Adults 50
- 99 0.006109 6.2% Female 13
- 49 0.005974 6.1%

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