### dimethyl
- N
- phenyl
- 2
- pyrimidinamine] (CAS No. 53112
- 28
- 0) . The estimated drinking water concentrations (EDWCs) are estimated with the Surface Water Concentration Calculator (SWCC) and Pesticide Root Z one Model
- Ground W ater ( PRZM
- GW ) using the maximum application rate and number of applications, as there is no monitoring data available in USGS and CDPR databases . The EDWCs in this assessment represent the proposed new uses for S CALA ® Brand SC Fungicide (EPA Reg No. 264
- 788) on caneberry and bushberry, cucumbers in greenhouse, and the following crop group expansions: Pome Fruit Group 1 1 to Pome Fruit Group 11
- 10; Stone Fruit Group 12 to Stone Fruit Group 12
- 12; from Lemon to Lemon Subgroup 10
- 10B, and from Tomato Subgroup to Tomato S ubgro up 8
- 10A (Appendix 1 Table 1) . The request by IR4 for the conversion of the Citrus Fruit Group 10 to Orange Subgroup 10
- 10a and Grapefruit Subgroup 10
- 10C is not considered in this drinking water assessment , because these uses are not include d o n the current or amended label (EPA Reg No. 264

- 788) . The label (EPA Reg No. 264
- 788) and supporting documents submitted are inconsistent with respect to the total maximum allowed (i.e., on a per crop cycle or per year basis). The registrant has indicated that the label will be clarified so that only tomatoes and strawberries (low growing berries) could have 2 crop cycles per year. This assessment assumes that proposed maximum applications rates are the same as previously assessed (i.e., single and yearly basis) except for tomatoes and strawberries where 2 crops per year were a ssessed. IR
- 4 has requested to expand the citrus, pome and stone fruit crops for the existing postharvest uses for PENBOTEC ® 400 SC (EPA Reg. No. 43813

- 32). Based on the information provided, EFED considers the proposed post
- harvest dip use of pyrimethani l as an indoor use that would pose minimal exposure to the environment, provided that release of the chemical and contaminated water are controlled. The Health Effects Division 1 

### previously determined that the drinking water exposure assessment should include the degradate (2

- amino
- 4,6
- dimethylpyrimidine) . Therefore , the estimated drinking water concentrations (EDWCs) in this assessment include the combined residue (total toxic residue : pyrimethanil + 2
- amino
- 4,6
- dimethylpyrimidine ) as in p rior assessment s . The screening level drinking water concentrations for combined residues of pyrimethanil (parent + 2

- amino
- 4,6
- dimethylpyrimidine) in s urface water are not expected to exceed 156 μg/L for the peak 1 in 10
- year concentration; 2 7 .9 μg/L for the 1 in10
- year annual mean concentration; and, 21.3 μg/L for the 30 year annual average concentration for the new uses or crop group expansion ( assuming 2 crops per year 2 

### ) . The screening level drinking water concentrations for combined residues of py rimethanil (parent + 2
- amino
- 4,6
- dimethylpyrimidine) in groundwater estimated with PRZM
- GW are 128 μg/L for the highest daily value and 1 17 μg/L for the post
- break
- through average ( Table 1 ). Current policy is for EFED to recommend the EDWCs for the water source with the highest EDWCs, which for pyrimethanil is surface water for acute exposure and groundwater for chronic exposure . However, due to generally low leaching (EDWCs and incomplete breakthrough) with 100 year simulation in groundwater, the surface water EDWCs are recommended for both acute and chronic (cancer and long term) exposure assessments. The EDWCs for the combined residues are presented below in Table 1 .

1 MARC Decision Memo D284001; 0 9/10/03 2 1 crop per year – peak 68 μg/L; annual average = 18 μg/L, and 30 year average = 13 μg/L. 

### 2Table 1 . Surface Water and Ground w ater EDWCs for Pyrimethanil plus the degradate (2 - amino - 4,6 - dimethylpyrimidine) for the proposed new uses and crop group expansions for SCALA brand SC Fungicide (EPA Reg No. 264 - 788) assuming the maximum application rate (3 or 6 applications @ 0.7 lb a.i./ A/year) . 

### S tandard S cenario s Model Application Rate 1 - in - 10 year 30 Year 

### Surface Water #/lb a.i./A Peak Annual Mean Mean (ug/L) 

### Multiple Scenarios a - f 

### SWCC 3 @ 0.7/7 per crop cycle/2 crop cycles 156 a 

### 27. 9 b 

### 21.3 c 

### 3 @ 0.7/7 per crop cycle/1 crop cycles 67.8 d 

### 17 .5 e 

### 13.1 f 

### Ground w ater Highest Daily Value Post - breakthrough Average 

### FL Citrus PRZM
- GW 3 @ 0.7/7 per crop cycle/2 crop cycles 128 117 

### FL Potato 3 @ 0.7/7 per crop cycle/ 2 crop cycles 25.2 22.7

a FL Strawberry (2 crop cycle s) b PA Tomato (2 crops cycles ) c CA Grape (2 crops cycles ) d FL Strawberry (1 crop cycle ) e PA Apple (1 crop cycle ) f GA Peach (1 crop cycle ) 

### Proposed New Uses and Crop Group Expansion BayerCropscience has requested the addition of two new use s for pyrimethanil [SCALA® brand SC Fungicide, EPA Reg. No. 264
- 788] on c aneberry [ berries and small fruit
- crop subgroup 13
- 07A ] and bushberry [ berries and small fruit crop subgroup 13
- 07B ] and IR
- 4 has requested a new use for pyrimethanil [SCALA® brand SC Fungicide, EPA Reg. No. 264
- 788] on cucumber s in greenhouse . The proposed use on cucumbers is for greenhouse use (indoor) and th erefore not assessed. IR
- 4 has also requested the following crop group expansions: Pome F ruit G roup 11 to Pome F ruit G roup 11
- 10; Stone F ruit Group 12 to Stone F ruit Group 12
- 12; and from Tomato Subgroup to Tomato Subgroup 8
- 10A; and Citrus F ruit G roup 10 to O range S ubgroup 10
- 10a , from Lemon to Lemon S ubgroup 10
- 10B, and G rapefruit S ubgroup 10
- 10C; (Appendix 1) . However, t he current label and the proposed amended label (EPA Registration No. 264

- 788), only specifi es Lemon F ruit Group , but not the other citrus fruit s (e.g., citrus group, or Orange 10

- 10A and Grapefruit subgroups 10
- 10C subgroups). For the PENBOT E C® 400 SC EPA Reg. No. 43813
- 32 registration, IR
- 4 has also requested that the label be amended to expand the crops considered in the citrus, pome and stone fruit crop groups for postharvest use of pyrimethanil (Appendix 2) . As stated earlier, EFED considers the proposed post
- harvest dip use of pyrimethanil as an indoor use that would pose minimal exposure to the environment, provided that release of the chemi cal and contaminated water are controlled.



### 3

### A summary of the new uses and label amendments is provided in Table 2 and Appendix 2 . Table 2 . Submission, Registration, Proposed New Use or Group Expansion, and Subgroups. Barcode/e - submission / submitter Label (EPA Reg. No.) New Use /Group Expansion (see Appendix 1) Subg roup s (see Appendix 1 ) D422492 a /E6065/Bayer 264
- 788 SCALA® brand SC Fungicide Small Berries: Caneberry Bushberry 

### crop subgroup 13
- 07A crop subgroup 13
- 07 B 264
- 704 Pyrimethanil Technical Small Berries: Caneberry Bushberry 

### crop subgroup 13
- 07A crop subgroup 13
- 07 B D423016/E6210/ IR
- 4 264
- 704 Pyrimethanil Technical Greenhouse Cucumber

Citrus fruit Pome fruits 11
- 10 Stone fruits 12
- 12 Tomato subgroup 8
- 10A Subgroups (orange, lemon, grapefruit) are not specified D422295/E6215/ IR
- 4 264
- 788 b SCALA ® b rand SC Fungicide Greenhouse Cucumber

Not include d b :

Orange Grapefruit Lemons 10
- 10B Tomatoes 8
- 10A Pome fruits 11
- 10 Stone fruits 12
- 12 Not includ ed b : Orange Subgroup 10
- 10A Grapefruit Subgroup 10
- 10C D422295/E6215/ IR
- 4 43813
- 32 PENBOTEC® 400 SC Increase crops and varieties Citrus Fruits Pome Fruits Stone Fruits a Parent DP Barcode D421847 b Only use rates for lemons (not citrus) are specified in current or modified label (EPA Reg. No. 264

- 788). 

### The proposed maximum single application rate for pyrimethanil that is assessed in this document is 0.70 lb a.i./A with a per crop maximum applicati on rate of 2.1 lb a.i./A and a minimum reapplication interval of 7 days, for strawberries (Table 3) . In California, strawberry cultivation and harvesting is year
- round. Therefore, the two crop cycles are spaced out at the minimum reapplication interval of 7 days. In total, the maximum amount of pyrimethanil active ingredient on a yearly basis t o treat strawberries is 4.2 lb a.i./A. Tomatoes can be grown indoors (in greenhouses) or outdoors. The small berry subgroup (caneberries and bushberries) represents the lowest application rate group in this assessment.



### 4Table 3. Proposed new use and expanded use patterns and maximum single and seasonal application rates for pyrimethanil a (DP 421847, DP422295) . Crop/Use New Use: Proposed Application Rates Previously Assessed Application Rates Max Single App Rate Max App Rate per Year Minimum Reapplication Interval Max Single App Rate Max App Rate per

Year Minimum Reapplication Interval lb a.i./A lb a.i./A/yr days lb a.i./A lb a.i./A/yr days Small Berries (Subgroups 13

- 07A & 13
- 07B: Caneberry/Bushberry) b 0.7 1.41 7
- - - Cucumber (greenhouse only) (max 3 crop cycles per year)
* No outdoor exposure assessment 0.7 2.1 per crop; 6.3 per year 7
- - -

Tomato subgroup (max 2 crop cycles per year ) c
* Greenhouse use optional 0.27 1.4 per crop; 2.8 per year 7 0.27 1.4 7

Low
- growing berry; Strawberries (13

- 07G) 0.7 2.1 per crop, 4.2 per year

– strawberry 2.1 per year

– all except strawberry 7 0.7 2.1 7

Pome Fruit 11
- 10 0. 4 1.6 7 0.39 1.62 7 Stone Fruit 12
- 12 0.7 2.1 7 0.7 2.14 7

a EPA Reg. No. 264
- 788 SCALA ® Brand SC Fungicide 54.6 % ai 5.0 lb ai/gallon [0.039063 lb ai/fl oz] b Small berries (caneberries and bushberries). Blackberry: Rubus spp. (including Andean Blackberry, artic blackberry, bingleberry, black satin berry, boysenberry, brombeere, CA blackberry, Chesterberry, Cherokee blackberry, Cheyenne blackberry, common blackberry, coryberry, darrowberry, dewberry, Dirksen thornless berr y, evergreen blackberry, Himalayaberry, hullberry, lavacaberry, loganberry, lowberry, lucretiaberry, mammoth blackberry, marionberry, mora, mures deronce, nectarberry, Northern dewberry, olallieberry, Oregon evergreen berry, phenomenalberry, rangeberry, ra venberry, rossberry, Shawnee blackberry, Southern dewberry, tayberry, youngberry, zarzamora), and cultivars, varieties and/or hybrids of these; Raspberry: Rubus spp. ( Rubus occidentalis, Rubus strigosus, Rubus idaeus ) (including bababerry, black raspberry, blackcap, framboise, frambueso, himbeere, keriberry, Mayberry, purple raspberry, red raspberry, thimbleberry, tulameen, wild raspberries, yellow raspberry) and cultivars, varieties, and/or hybrids of these; Bushberry: aronia berry; blueberry (highbush, lo wbush); currant (black, red); European barberry, elderberry, gooseberry, honeysuckle, huckleberry, jostaberry, juneberry, native currant, salal, buckthorn, sea, and cultivars, varieties, and/or hybrids of these. c Bush tomato, cocona, currant tomato, garde n huckleberry, goji berry, groundcherry, naranjilla, sunberry, tomatillo, tomato, tree tomato, cultivars, varieties and/or hybrids of these.


### 5

### Environmental Fate Summary The major route of dissipation of pyrimethanil is metabolism under aerobic conditions (soil; water

sediment). It is stable to abiotic hydrolysis, direct photolysis in water, and under anaerobic conditions. It is expected to have varying mobility in soil. Pyrimethanil has low potential to volatilize from soil or water or to bioaccumulate in fish. The “major” non
- volatile metabolite is 2
- amino
- 4,6
- dimethylpyrimidine, but it was not found at >10% of the applied radioactivity. Carbon dioxide is a major metabolic product (18

- 25% after 1
- year incubation in aerobic soils) . The metabolite 2
- amino
- 4,6
- dimethylpyrimidine is a cleavage product that may be more resistant to aerobic degradation and/or more mobile than pyrimethanil ( Table 4 ). However, mineralization is likely associated with this metabolite. The metabolite 2
- amino
- 4,6
- dimethylpyrimidine is also a bridge cleavage product of sulfometuron, a sulfonylurea herbicide. The structures, chemical name, CAS No. and f ormula for pyrimethanil and the metabolite are shown in Figure 1.

Chemical: Parent pyrimethanil Degradate of Concern Chemical Name: 4,6
- Dimethyl
- N
- phenyl
- 2
- pyridineamine 2
- amino
- 4 , 6
- dimethyl pyrimidine CAS No. 53112
- 28
- 0 CAS No. 767
- 15
- 7 Chemical Formula: C 12 H 13 N 3 C 6 H 9 N 3 

### Figure 1. Structures , Name, CAS No. and For mula of pyrimethanil and 2 - amino - 4,6 - d i methyl pyrimidine . Chemical Residues of Concern (ROC) The major non
- volatile degradate is 2
- amino
- 4,6
- dimethylpyrimidine [CAS # 767
- 15
- 7] . The Health Effects Division (HED) recommended the degradate 2
- amino
- 4,6
- dimethylpyrimidine be included in the drinking water assessment(s) (MARC Decision Memo D284001; 9/10/03). For this reason, the drinking water assessment is a combined residue assessment (pyrimethanil + 2

- amino
- 4,6
- dimethylpyrimidine).



### 6Tabl e 4 . Input Parameters a Used to Estimate Concentrations of Combined Residues (Parent and 2 - Amino - 4,6 - dimethylpyrimidine) for Pyrimethanil (bold values used for modeling) .

Parameters Values & Units Sources Molecular Weight 199.25 Product Chemistry (parent) Vapor Pressure @ 25 ° C 1.7 x 10 – 5 torr Product Chemistry (parent) Water Solubility @ pH 7.0 and 25 o C 121 mg/L Product Chemistry (parent) Hydrolysis Half
- Life (pH 7) stable MRID 456459
- 15 (parent) Aerobic Soil Metabolism Half
- life (@ 2 0 o C ) 81
- 110.7 days 263 days (combined residues) @ 20°C 186 days @ 25°C Parent Pyrimethanil MRID 45656918/

- 19/

- 20/

- 21/

- 22 C alculated from MRID 456569
- 18, single v alue half
- life (3 times single value ) for TTR ; the only Study where 2
- amino
- 4,6
- dimethylpyrimidine was identified. Aerobic Aquatic Metabolism (total sediment/water system) (@ 2 0 o C ) 37 ; 12 0.7 days 207 days (combined residues) @ 20°C 146 days @ 25°C Parent Pyrimethanil MRID 45657001 Calculated for Combined Residues from MRID 456570
- 01 (90% confidence interval on mean; Experimental) for TTR Anaerobic Aquatic Metabolism (total sediment/water system) (@20 o C) 1092 days @ 20°C 772 days @ 25°C MRID 456569
- 23 (half

- life time 3 for single value). Direct Aqueous Photolysis stable MRID 456459
- 16 (parent) Soil Water Partition Coefficient (Freundlich K d ) K oc 75
- 751mL/g oc K d 2.5
- 23.4 mL/g Ave K d - 2.85 mL/g (combined residues) A ve K oc = 119 mL/g oc (combined residues) Parent Pyrimethanil MRID 45656911/

- 13/

- 25 

### Degradate 2
- amino
- 4,6
- dimethylpyrimidine Average K d (degradate) MRID 456569

- 10 (1.9, 2.2, 1.2, 5.2, 3.5, 3.1) for TTR Average K oc (degradate) (60, 256, 76, 109, 74, 139) Percent Crop Area (PCA ) 1.0 EFED G uidance b ; Maximum PCA for Turf
- All Ag. [previous assessment
– All Ag . 0.87 ; USEPA, 2010 c ] Date of First Application See Table 6

- Application Efficiency (Aerial Spray) 0.95 EFED G uidance a Spray Drift Fraction (Aerial Spray) 0.1 3 5 EFED G uidance d [previous assessment
- 0.16] a Inputs determined in accordance with EFED “ Guidance for Chemistry and Management Practice Input Parameters for Use in

Modeling the Environmental Fate and Transport of Pesticides” Version 2.1 dated October 22, 2009. b USEPA. 2014. Development of Community Water System Drinking Water Intake Percent Cropped Area Adjustment Factors for

use in Drinking Water Exposure Assessments: 2014 Update September 9, 2014. c USEPA, 2010. http://www.epa.gov/pesticides/science/efed/models/water/archives/pca_adjustment_dwa_9sep2010.html 

### 7d USEPA . 2013. Guidance on Modeling Offsite Deposition of Pesticides Via Spray Drift for Ecological and Drinking Water Assessments December 19, 2013. 

### Because pyrimethanil is to be applied when conditions are favorable to the disease rather than a plant growth stage , there is uncert ainty as to what is a representative date of first application. The day of initial application was a specified number of days ( see Table 5 ) after emergence [DAE] (day of emergence is defined specifically for each scenario). For pyrimethanil , the day of ini tial pesticide application tended to have a greater influence on surface water concentration estimates than groundwater. Summary of Drinking Water Concentrations Surface Water EDWCs estimated with SWCC Surface water concentrations estimated with the SWCC for a number of scenarios and maximum use rates are listed in Table 5 . The screening level drinking water concentrations for combined residues of pyrimethanil (parent + 2

- amino
- 4,6
- dimethylpyrimidine) in raw surface source water are not expected to exceed 1 56 μg/L for the peak 1 in 10
- year concentration (FL strawberry) ; 28 μg/L for the 1 in10
- year annual mean concentration; and, 21.3 μg/L for the 30 year annual average concentration (CA grape ) . Several comments concerning the unce rtainty of these EDWCs should be noted. T he highest modeled EDWC was for the FL Strawberry scenario with “2 crops” per year (6 applications of pyrimethanil per year); however, “2 crops” per year may be more appropriate for California rather than Florida (i.e., FL Strawberries compared with CA grapes). Additionally, it is unlikely that 2 tomato crops per year would be achieved in Pennsylvania (e.g., PA tomato scenario). Because of crops registered for pyrimethanil, t he actual PCA is probably less than the default value of 1 which is used to estimate the EDWCs. A r epresentative SWCC output is included in Appendix 3 . Table 5 . SWCC Est imated Drinking Water Concentrations (EDWCs) in surface water for pyrimethanil (parent + 2 - amino 4,6 - dimethylpyrimidine) for new uses or crop group expansions. Scenario First Application/# @Rate/Interval 1 - in - 10 Year 30 - Year Peak Annual mean Total mean (Days/lb a.i./A/Days) μg/L FL Strawberry 3 0 DAE/ 2 @ 0.7 0 /7 57.6 8.75 5.11 30 DAE 4 @ 0.70/7 b 89. 0 18.1 9.99 GA Peach (Stone Fruit) 60 DAE/3 @ 0.7 0 /7 30.6 15.9 13.1 NY Grape 60 DAE/ 2 @ 0.7 0 /7 37.3 16.9 11.2 PA Apple (Pome Fruit) 50 DAE/4 @ 0.4 0 /7 42.0 17.5 11.0 PA Tomato [1 or 2 crops] 30 DAE/5 @ 0.25/7 32.0 10.2 7.43 30 DAE/10 @ 0.25/7 b 79.8 27.9 18.3 FL Tomato [1 or 2 crops] 30 DAE/5 @ 0.25/7 65.3 10.1 5.05 30 DAE/10 @ 0.25/7 b 98.6 20.0 12.8 FL Strawberry/ Low growing berries [1or2 crops] 30 DAE/ 3 @ 0. 70 /7 67.8 13.5 7.46 30 DAE/6 @ 0.70/7 b 156 24.3 15.6 CA Grapes/Low growing berries [2 crops] 30 DAE/ 6 @ 0. 70 /7 b 49.8 27.3 21.3 a DAE is days after emergence which specified within each scenario b 2 crop cycles per year all others 1 crop per year. 

### 8

### Groundw ater EDWCs estimated with PRZM - GW PRZM
- GW (Version 1.07) was used to estimate ground water EDWCs for the six standard EFED vulnerable groundwater scenarios ( Table 6 ) with the maximum proposed use rate of 2.1 lb a.i./A/yr (3 applications x 0.7 lb a.i/A /yr ) . Because there is a potential a second crop for tomatoes and strawberries t he Florida Citrus and Florida Potato PRZM
- GW scenarios with 2 crops per year with 3 applications @ 0.7 lb a.i./A/crop were also run
. T he Florida Citrus scenario r esulted in the highest groundwater EDWC s when tw o crops per year were simulated . It was note d that the d ate of initial application selected for modeling had little influence on the peak or post
- break average EDWCs. Even when simulations were run for 100 years , breakthrough did not occur for all scenario s, s uggesting that leaching is not a major route of dissipation. It is also unlikely that pyrimethanil will be used for 30 consecutive years, much less 100. Furthermore, it is unlikely that people will be exposed to pyrimethanil concentrations at these levels based on the available fate data, as well as the predicted breakthrough time of over 30 years, or lack of breakthrough. It should also be noted that all six of the scenarios represent vulnerable conditions where pesticides have been observed in ground water . The scenarios also would tend to represent di fferences due to soil, hydrology, and weather variability rather than any specific crop. A representative PRZM
- GW output is in Appendix 4 . Table 6. PRZM - GW Estimated Drinking Water Concentrations (EDWCs) in Ground w ater for pyrimethanil (parent + 2 - amino - 4,6 - dimethylpyrimidine) Scenario a First Application/Simulation Length Highest Daily Value Post
- breakthrough Average Average Breakthrough Time/Throughputs (day/year s ) μg/L Days 1 crop cycle per year Delmarva 10 DAE b /100 22.7 18.5 23467/1.5 FL Citrus 30 DAE/100 30 DAE/30 65.1 28.7 59.6 Incomplete c 12857/2.8 incomplete FL Potato 30 DAE/100 30 DAE/30 13.2 7.35 12.0 incomplete 10972/3.3 incomplete GA Coast 30 DAE/100 30 DAE/30 17.1 0.29 15.3 incomplete 18974/1.9 incomplete NC Coast 30 DAE/100 30 DAE/30 4.86 0.006 4.62 incomplete 34506/1.0 incomplete Wisc Sand 30 DAE/100 30 DAE/30 4.62 <0.01 Incomplete incomplete Incomplete incomplete 2 crop cycles per year FL Citrus d 30 DAE/100 128 117 12857/2.8 FL Potato d 30 DAE/100 25.2 22.7 10972/3.3 a All application rates = 3 applications @ 0.7 lb a.i./A; 7 day reapplication interval except for F L Citrus d and FL Potato d 2 crops per year with 3 application @ 0.7 lb a.i./A/crop; or 4.2 lb a.i./yr. b DAE is days after emergence which specified within each scenario. c Incomplete
– breakthrough not achieved during the simulation. d Application rate = 2 crops per year ; 3 application @ 0.7 lb a.i./A/ crop



### 9

### Appendix 1. Crop Groups Proposed for Expansion Appendix 1 Crop Groups Proposed for Expansion . Crop Group Crops (Current Label: 264 - 788) Expanded Crops (Proposed Label) Pome Fruit s Apple; Pear (All varieties); Pear, Oriental; Crabapple; Loquat; Mayhaw; Quince Apple; azarole; crabapple; loquat; mayhaw; medlar; pear; pear, Asian; quince; quince, Chinese; quince, Japanese; tejocote; cultivars, varieties, and/or hybrids of these Stone Fruit s (except cherries) Apricot; Nectarine; Peach; Plum (All varieties); Plum, Chickasaw; Plum, Damson; Plum, Japanese; Pl um, Stanley; Plumcot; Prune Apricot; apricot, Japanese; capulin; Jujube, Chinese; nectarine; peach; plum; plum, American; plum, beach; plum, Canada; plum, cherry; plum, Chickasaw; plum, Damson; plum, Japanese; plum, Klamath; plum, prune; plumcot; sloe; cul tivars, varieties, and/or hybrids of these Tomato e s Tomato Bush tomato; cocona; currant tomato; garden huckleberry; goji berry; groundcherry; naranjilla; sunberry; tomatillo; tomato; tree tomato; cultivars, varieties, and/or hybrids of these Lemons Lemon Australian desert lime; Australian finger
- lime; Australian round lime; brown river finger lime; kumquat; lemon; lime; mount white lime; New Guinea wild lime; Russell River lime; sweet lime; Tahiti lime; cultivars, varieties, and/or hybrids of these. Crop Groups Crops (Current Label: 43813 - 32) Expanded Crops (Proposed Label) Citrus Fruits Calamondin, Citrus citron, Citrus hybrids (includes chironja, tangelo & tangor), Grapefruit, Kumquat, Lemon, Lime, Mandarin, Orange (sour & sweet), Pummelo, Satsuma mandarin, tangerine, and all cultivars and hybrids CITRUS FRUITS: Australian lime (desert, finger, round), Brown River finger lime, Calamondin, Citron, Citrus hybrids, Grapefruit, Japanese summer grapefruit, Kumquat, Lemon, Lime, Mediterranean mand arin, Mount White lime, New Guinea wild lime, Orange (sour & sweet), Pummelo, Russell River lime, Satsuma mandarin, Sweet lime, Tachibana orange, Tahiti lime, Tangelo, Tangerine (mandarin), Tangor, Trifoliate orange, Uniq fruit, and all cultivars, varietie s, and/or hybrids of these. Pome Fruits Apples, Crabapple, Loquat, Mayhaw, Pear, Oriental pear, Quince Apple, Azarole, Crabapple, Loquat, Mayhaw, Medlar, Pear, Pear (Asian), Quince, Quince (Chinese & Japanese), Tejocote , and all cultivar, varieties and/or hybrids of these. Stone Fruit s Apricot, Cherry (sweet & tart), Nectarine, Peach, Plum (including Chickasaw, Damson, & Japanese), Plumcot, Prune (fresh) Apricot, Apricot (Japanese), Capulin, Cherry (black, Nanking, swe et & tart), Jujube (Chinese), Nectarine, Peach, Plum, Plum (American, beach, Canada, cherry, Chickasaw, Damson, Japanese, Klamath, prune), Plumcot, Sloe, and cultivars, varieties and/or hybrids of these. Stone Fruits ( except Cherry ) Apricot, Nectarine, P each, Plum (including Chickasaw, Damson, & Japanese), Plumcot and Prune (fresh) Apricot, Apricot (Japanese), Capulin, Jujube (Chinese), Nectarine, Peach, Plum, Plum (American, beach, Canada, cherry, Chickasaw, Damson, Japanese, Klamath, prune), Plumcot, Sl oe, and cultivars, varieties and/or hybrids of these.



### 10Appendix 2. Detailed P yrimethanil New Uses and Label Amendments ( IR - 4 & Registrant Requests ) Requestor Crop (expanded crops Appendix 1 Table 1) Single Application/Concentration (Max application); Reapplication Interval Method Application Notes EPA Reg. No. 264
- 788, Scala SC Fungicide* EPA
- Reg No. 264
- 704, Pyrimethanil Technical *For bulb vegetable, small fruit vine climbing, lemon, stone fruit, pome fruit, low growing berry, the ‘change’ on the h ighlighted label is addition of lower application rates when this is tank mixed with another fungicide. Bayer b ( D422492 ; E6065 ) Caneberry Crop subgroup 13
- 07A 0.35 – 0.70 lb a.i./A (1.41 lb a.i./year) 7 days Ground, aerial spray No PHI Bayer ( D422492 ; E6065 ) Bushberry, Crop subgroup 12
- 06B 13
- 07B (low

- growing berry) 0.35 – 0.70 lb a.i./A (1.41 lb a.i./acre or crop) 7 days Ground, aerial spray Conflicting information: registrant label says max application per year, but IR
- 4 petition label includes low
growing berries, and max application per crop. This is a problem with the rest of Bayer’s label which says per crop. EPA Reg No. 264 - 704, Pyrimethanil Technical

EPA Reg No. 2644 - 788, Scala SC Fungicide IR
- 4 a (D423016; E6210) IR
- 4 (D422295; E6215) Cucumber (greenhouse) 0.70 lb a.i./A (2.1 lb a.i./season) 7 – 14 days Ground spray Only plastic tunnel houses or glass houses. 1 Day PHI IR
- 4 (D423016; E6210) Tomato Subgroup 8
- 10A 0.27 lb a.i./A (1.4 lb a.i./ crop ) 7 – 14 days Ground, aerial spray, and chemigation 1 Day PHI Scala®brand SC Fungicide Expanded Crop Group s Considered Pome Fruit group 11 IR
- 4 (D422295; E6215) Expand Fruit pome fruit group to revised Fruit, pome group 11
- 10 0.39 lb a.i./A (1.6 lb a.i./A/crop?) 7 days Ground, aerial spray, and chemigation Citrus Fruit Group 10 Orange subgroup 10
- 10A Not specified
- Not included in Draft label E6215, D422295 IR
- 4 (D422295; E6215) Lemon subgroup 10
- 10B 0.7 lb a.i./A (0.7 lb a.i./A/season?) Ground, aerial spray, and chemigation Grapefruit subgroup 10
- 10C Not Specified
- Not included in Draft label E6215, D422295 Stone Fruit Group 12 IR
- 4 (D422295; E6215) Stone Fruit group 12
- 12 (except Cherries) 0.70 lb a.i./A (2.1 lb a.i./A/per crop?) 7 days Ground, aerial spray, and chemigation IR
- 4 (D422295;E6215) Tomato subgroup 8
- 10A 0.27 lb a.i./A (1.4 lb a.i./A/per crop?) 7
- 14 days Ground, aerial spray, and chemigation EPA Reg. No. 43813 - 32 Penbotec 400 SC For post - harvest use on citrus, pome, and stone fruit Requestor Crop Single Application/Concentration (Max application); Reapplication Interval Method Application Notes IR
- 4 (D422295/E6215) Citrus ( lemon, orange, grapefruit) 1000 ppm (32 oz product/100 gal) Dip, wash tank for 2 minutes In some instances, up to a combination of three applications can be made; see label for permutations. IR
- 4 (D422295/E6215) 500 ppm 16 oz product/100 gal) Drencher for 2
– 4 minutes IR
- 4 (D422295/E6215) 2000 ppm (64 oz product/100 gal) Aqueous line spray for 1 minute IR
- 4 (D422295/E6215) 2000 ppm (64 oz product/100 gal) Wax line spray (storage & Pack wax) For 1 minute IR
- 4 (D422295/E6215) Pome 500 – 1000 ppm (16
– 32 oz product/100 gal) Dip, wash tank for 1 minute In some instances, up to a combination of two applications can be made; see 

### 11Requestor Crop (expanded crops Appendix 1 Table 1) Single Application/Concentration (Max application); Reapplication Interval Method Application Notes IR
- 4 (D422295/E6215) 500 – 1000 ppm (16
– 32 oz product/100 gal) Drencher for 1 minute label for permutations. IR
- 4 (D422295/E6215) 1000 ppm (32 oz product/100 gal) Aqueous line spray for 1 minute IR
- 4 (D422295/E6215) 2000 ppm (64 oz product/100 gal) Wax line spray (storage & Pack wax) For 1 minute IR
- 4 (D422295/E6215) Stone fruit 500 ppm 16 oz product/100 gal Dip tank for 0.5 minute Only one type of application permitted IR
- 4 (D422295/E6215) 500 ppm 16 oz product/100 gal High volume line spray/flood application (aqueous/water

wax/wax

- oil emulsion) 0.5 minute IR
- 4 (D422295/E6215) Stone fruit, except cherry 4 g a.i./ton fruit 33.8 oz product/80
– 120 gal Low volume line spray/flood application (aqueous/water

wax/wax

- oil emulsion) Only one type of application permitted 264 - 788 Pyrimethanil Technical IR
- 4 Pyrimethanil Technical 264
- 788 43813
- 32 264
- 704 Technical [E6210] Gree n house Cumber Pome fruits group 11
- 10 Stone fruit group 12
- 12 Tomato subgroup 8
- 10A NA NA NA



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### Appendix 3 . S urface W ater C oncentration C alculator O utput Summary of Water Modeling of Pyrimethanil combined residues and the USEPA Standard Reservoir Estimated Environmental Concentrations for Pyrimethanil combined residues are presented in Table 1 for the USEPA standard reservoir with the FLstrawberry_WirrigSTD field scenario. A graphical presentation of the year
- to - year peaks is presented in Figure 1. These values were generated with the Surface Water Concentration Calculator (SWCC Version 1.106). Critical input values for the model are summarized in Tables 2 and 3. This model estimates that about 1.6% of Pyrimethanil combined residues applied to the field eventually reaches the water body. The main mechanism of transport from the field to the water body is by runoff (74.8% of the total transport), followed by spray drift (25.2%) and erosion (0.05%). In the water body, pesticide dissipates with an effe ctive water column half
- life of 40.7 days. (This value does not include dissipation by transport to the benthic region; it includes only processes that result in removal of pesticide from the complete system.) The main source of dissipation in the water co lumn is washout (effective average half

- life = 53.7 days) followed by metabolism (171.7 days) and volatilization (7069.7 days). In the benthic region, pesticide dissipates very slowly (908.0 days). The main source of dissipation in the benthic region is m etabolism (effective average half

- life = 908 days). Most of the pesticide in the benthic region (89%) is sorbed to sediment rather than in the pore water. Table 1. Estimated Environmental Concentrations (ppb) for Pyrimethanil combined residues. Peak (1

- in
- 10 yr) 156. 4
- day Avg (1

- in
- 10 yr) 151. 21
- day Avg (1

- in
- 10 yr) 143. 60
- day Avg (1

- in
- 10 yr) 104. 365
- day Avg (1

- in
- 10 yr) 24.3 Entire Simulation Mean 15.6 Table 2. Summary of Model Inputs for Pyrimethanil combined residues. Scenario FLstrawberry_WirrigSTD Cropped Area Fraction 1.0 Koc (ml/g) 2.85 Water Half
- Life (days) @ 25 °C 146 Benthic Half
- Life (days) @ 25 °C 772 Photolysis Half
- Life (days) @ 45 °Lat 0 Hydrolysis Half
- Life (days) 0 Soil Half
- Life (days) @ 25 °C 186 

### 13

### Foliar Half
- Life (days) 0 Molecular Wt 199.25 Vapor Pressure (torr) 1.75e
- 5 Solubility (mg/l) 121 Table 3. Application Schedule for Pyrimethanil combined residues. Date (Days Since Emergence) Type Amount (kg/ha) Eff. Drift 30 Foliar 0.784 0.95 0.135 37 Foliar 0.784 0.95 0.135 44 Foliar 0.784 0.95 0.135 51 Foliar 0.784 0.95 0.135 58 Foliar 0.784 0.95 0.135 65 Foliar 0.784 0.95 0.135 

### Figure 1. Yearly Peak Concentrations

14

### Appendix 4 . PRZM - GW output Groundwater Analysis for pyrimethanil ROC and the Florida Citrus - FL Central Ridge, Polk County - (Tampa) Met File (12842.Dvf) - Astatula Sand, Hrgb A Scenario Estimated groundwater concentrations and breakthrough times for pyrimethanil ROC are presented in Table 1 for the Florida Citrus
- FL Central Ridge, Polk County
- (Tampa) Met File (12842.dvf)

- Astatula sand, hrgb A groundwater scenario. A graphical presentation of the daily concentrations in the aquifer is presented in Figure 1. These values were generated with the PRZM
- GW (Version 1.07). Critical input values for the model are summarized in Tables 2 and 3 

### . Table 1. Groundwater Results for pyrimethanil ROC and the Florida Citrus - FL Central Ridge, Polk County - (Tampa) Met File (12842.dvf) - Asta tula sand, hrgb A Scenario. Peak Concentration (ppb) 128 Post
- Breakthrough Mean Concentration (ppb) 117 Entire Simulation Mean Concentration (ppb) 83 Average Breakthrough Time (days) 12856.9 Throughputs 2.812652 Table 2. Chemical Properties for Groundwater Modeling of pyrimethanil ROC. Kd (ml/g) 2.85 Surface Soil Half Life (days) 186 Hydrolysis Half Life (days) 0 Diffusion Coefficint Air (cm2/day) 0.0 Henry's Constant 0.0 Enthalpy (kcal/mol) 0.0



### 15

### Table 3. Pesticide application scheme used for pyrimethanil ROC. This application scheme was applied every year of the simulation. Application Days Relative to Emergence Date (01/01) Application Method Application Rate (kg/ha) 10 Above canopy application 0.784 17 Above canopy application 0.784 24 Above canopy application 0.784 84 Above canopy application 0.784 91 Above canopy application 0.784 98 Above canopy application 0.784 Figure 1. Aquifer Breakthrough Curve for pyrimethanil ROC and the Florida Citrus - FL Central Ridge, Polk County - (Tampa) Met File (12842.Dvf) - Astatula Sand, Hrgb A Scenario



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