```

[Federal Register: August 30, 2010 (Volume 75, Number 167)]
[Notices]               
[Page 52951-52952]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr30au10-67]                         

-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Healthcare Research and Quality

 
Agency Information Collection Activities: Proposed Collection; 
Comment Request

AGENCY: Agency for Healthcare Research and Quality, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: This notice announces the intention of the Agency for 
Healthcare Research and Quality (AHRQ) to request that the Office of 
Management and Budget (OMB) approve the proposed information collection 
project: ``Understanding Patients' Knowledge and Use of Acetaminophen--
Phase 2.'' In accordance with the Paperwork Reduction Act, 44 U.S.C. 
3501-3520, AHRQ invites the public to comment on this proposed 
information collection.

DATES: Comments on this notice must be received by October 29, 2010.

ADDRESSES: Written comments should be submitted to: Doris Lefkowitz, 
Reports Clearance Officer, AHRQ, by e-mail at 
doris.lefkowitz@AHRQ.hhs.gov. Copies of the proposed collection plans, 
data collection instruments, and specific details on the estimated 
burden can be obtained from the AHRQ Reports Clearance Officer.

FOR FURTHER INFORMATION CONTACT: Doris Lefkowitz, AHRQ Reports 
Clearance Officer, (301) 427-1477, or by e-mail at 
doris.lefkowitz@AHRQ.hhs.gov.

SUPPLEMENTARY INFORMATION: 

Proposed Project

Understanding Patients' Knowledge and Use of Acetaminophen--Phase 2

    AHRQ proposes a cross-sectional prospective survey to identify 
issues that relate to the misuse and overdosing of over-the-counter 
(OTC) acetaminophen. The survey was developed based on results from a 
previous data collection (OMB control number 0935-0154, approved on 10/
13/2009). Acetaminophen is the most widely used analgesic and 
antipyretic drug in the U.S. When appropriately used, it is a very safe 
agent. However, a single large overdose, or several supratherapeutic 
dosages in a short period of time, has been associated with acute liver 
failure, which can occur with dosages over 250 mg/kg over a 24-hour 
period, or > 12 g in an adult. Toxicity from acetaminophen has been on 
the rise in the past 3 decades, and is now the most common cause of 
acute liver failure in the U.S., surpassing viral hepatitis.
    This project has the following aims:
    (1) To estimate frequency of use, knowledge, and practices 
regarding use of OTC acetaminophen, and
    (2) To evaluate potential determinants of misuse in community-based 
samples.
    This information will be useful for policy makers to consider and 
to evaluate regulations and legislation with respect to the 
distribution, dispensing and sales of OTC acetaminophen.
    This study is being conducted by AHRQ through its contractor, the 
University of Texas. This project supports AHRQ's Centers for Education 
and Research on Therapeutics initiative to promote the safe and 
effective use of therapeutics. See 42 U.S.C. 299b-1(b). It also 
supports AHRQ's mandate for the inclusion of priority populations. See 
42 U.S.C. 299(c).

Method of Collection

    To achieve the projects' aims the following data collections will 
be implemented:
    (1) Surveys with parents of young children (age 60             150
 age............................................
Surveys with Adolescents (13 to 20 years of age)             200               1           30/60             100
Surveys with Adults (20 to 65 years)............             150               1           30/60              75
Surveys with Adults (greater than 65 years).....             150               1           30/60              75
                                                 ---------------------------------------------------------------

[[Page 52952]]

    Total.......................................             800              na              na             400
----------------------------------------------------------------------------------------------------------------

                                   EXHIBIT 2--Estimated Annualized Cost Burden
----------------------------------------------------------------------------------------------------------------
                                                     Number of     Total burden   Average hourly    Total cost
              Data collection mode                  respondents        hours        wage rate*        burden
----------------------------------------------------------------------------------------------------------------
Surveys with Parents of Children PRE>
```