## Aquatic Life Benchmarks for Pesticide Registration

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Introduction Relationship to ambient water quality criteria Use of aquatic life benchmarks OPP aquatic life benchmarks Footnotes Definitions References



## Introduction

The aquatic life benchmarks (for freshwater species ) provided in the table below are based on toxicityvalues reviewed by EPA and used in the Agency's mo st recent risk assessments developed as part of the decision-making process for pesticide registration. The Office of Pesticide Programs (OPP) in EPA relies on studies required under the Federal Insecticide, Fungicide, and Rodenticide Act(FIFRA), as specified at 40 CFR Part 158, as well as a wide range of environmental laboratory and field studies available in the public scientific literature to assess environmental risk. Each Aquatic Life Benchmark is basedon the most sensitive, scientifically acceptable toxicity endpoint available to EPA for a given taxon (for example, freshwater fish) of all scientifically acceptable toxicity data available to EPA. EPA's goal is to add to these benchmarks annually.



## Relationship to Ambient Water Quality Criteria

Both OPP and EPA's Office of Water (OW) have respon sibilities for evaluating aquatic toxicity data to assess the ecological effects of chemicals in surface water. Effects assessments under both program offices are develope d with high quality data pursuant to parallel but s omewhat different rigorously peer-reviewed assessment methods.
OW uses aquatic toxicity data to develop ambient water quality criteria that can be adopted by states and tribes to establish water quality standards under the Clean Water Act. Criteria are available for roughly 16 pe sticides. Procedures for deriving the criteria are described in Guidelinesa , and require, for acute criteria, that data be available for at least 8 families.
OPP uses aquatic toxicity data in ecological risk a ssessments for large numbers of pesticide registration decisions under FIFRA. OPP's procedures for eff ects assessment are described in the Overview Document b ; and rely, at a minimum, on data for the most sensitive tested effects concentration for each taxon.

Both the OW and OPP methods assess and characterizeeffects to protect aquatic communities.
The table below provides aquatic toxicity benchmarks, a reference for the most recent risk assessment conducted by OPP for each pesticide, and ambient water quality criteria, if available.



## Use of Aquatic Life Benchmarks

EPA worked initially with the USGS to identify aquatic ecotoxicity benchmarks values from risk assessm ents developed by EPA for individual pesticides during the recently completed re-registration program. The Overview Document and ecological risk assessments developed for individual pesticides provide useful information for understanding how these ecotoxicity benchmarks were developed andthe uncertainties associated with each benchmark. Comparing a measured concentration of a pesticide in water with an aquatic life benchmark can be helpful in interpreting monitoring data, and to identify and prioritize sites and pesticides that may require further investigation.
These aquatic benchmarks are extracted from the most recent publically available OPP risk assessment f or the pesticide and are based on the most sensitive aquatic toxicity data of the distribution for each taxa. Benchmarks,developed for baseline risk assessments, are estimates of the concentrations below which pesticides are not expected to harm aquatic life. OPP may further refine a risk as sessment based on the full distribution of toxicitydata for a given species, using point estimates, species sensitivity distribution approaches, or probabilistic methods.
OPP and OW are actively working together to harmonize the high quality, peer-reviewed scientific appro aches that now underlie both programs. A harmonizedapproach will result in consistent tools and approaches for all stakeholder communities to use in ensuring the prote ction of aquatic ecosystems.

OPP Aquatic Life Benchmarks (μg / L)

(freshwater)

Pesticide Year Updated CAS number Fish Invertebrates Nonvascular Plants Vascular

Plants Office of Water Aquatic Life Criteria

Acute 1 Chronic2 Acute 3 Chronic4 Acute 5 Acute 6 Maximum Concentration (CMC) Continuous

Concentration (CCC) 2,4-D 2014 94-75-7 12500 2,4-D acids and salts 94-75-7 12075 14200 12500 16050 3880 13.1 2,4-D esters

. 130 79.2 1100 200 66 330 2,4-D, 2-ethylhexyl ester 2014 1928-43-4 79.2 1700 152 330 2,4-D, Butoxyethyl ester 2014 1929-73-3 214 200 2,4-D, Diethanolamine salt 2014 5742-19-8 > 40800 16050 299.2 2,4-D, Dimethylamine salt 2014 2008-39-1 139000 23600 3880 2,4-D, Isopropyl ester 2014 94-11-1 130 1100 2,4-DB 94-82-6 1000 7500 932 2,4-DB-DMAS 2758-42-1 1567 10150 3, 6-dichlorosalicylic acid (DCSA) 3401-80-7 > 50000 44500 138000 > 73000 3-chloroacrylic acid degradate of Telone . 34750 27500 430 220 3-chloroallyl alcohol degradate of Telone . 493 1150 32900 1694 

## Aquatic Life Benchmarks for Pesticide Registration | Pesticide Science an... http://www.epa.gov/pesticide-science-and-assessing- pesticide-risks/aquat...

1 of 9 1/11/2016 5:11 PMPesticide Year Updated CAS number Fish Invertebrates Nonvascular Plants Vascular

Plants Office of Water Aquatic Life Criteria

Acute 1 Chronic2 Acute 3 Chronic4 Acute 5 Acute 6 Maximum Concentration (CMC) Continuous

Concentration (CCC) 3-Trifluoromethyl-4-Nitrophenol (TFM) 88-30-2 300 1900 1200 Abamectin 2014 71751-41-2 1.6 0.52 0.17 > 100000 3900 Acephate 30560-19-1 416000 5760 550 150 > 50000 Acequinocyl 57960-19-7 33500 520 1.2 0.98 960 Acetamiprid 2013 > 50000 19200 10.5 2.1 > 1000 > 1000 Acetochlor 34256-82-1 190 130 4100 22.1 1.43 3.4 Acetochlor degradate ethanesulfonic acid (ESA) 187022-11-3 > 90000 > 62500 9900 Acifluorfen sodium 62476-59-9 8500 < 1500 14050 > 265 378 Acrolein 107-02-8 7 11.4 > 15.5 7.1 28 72 3 3 Alachlor 15972-60-8 900 187 1250 110 1.64 2.3 Alachlor ethane sulfonic acid

. > 52000 > 52000 Alachlor oxanilic acid

. > 500000 > 47500 Aldicarb 116-06-3 26 0.46 10 1 > 5000 Aldicarb sulfone 1646-88-4 21000 140 Aldicarb sulfoxide 1646-87-3 3570 21.5 Aliphatic Oils- 100 Paraffine Oil 64742-54-7 > 50000 205 Aliphatic Oils- 70 Orchard Spray 64742-55-8 1200 Aliphatic Oils- 90 Neutral Oil 8012-95-1 > 50000 10 Aliphatic Oils- GB-1111

. > 60000 50 Aliphatic Oils- N65DW

. > 250000000 Aliphatic Oils- VHVI-4

. > 38000 < 450 Allethrin 584-79-2 9.5 1.05 Alpha-cypermethrin 2014 67375-30-8 1.1 0.14 0.0018 0.00059 > 33.5 > 1.39 Alpha-cypermethrin degradate (3-phenoxybenzoic acid) 3-phenoxybenzoic acid 2014 6650 44500 Aluminum Phosphide 2014 20859-73-8 Ametryn 2014 834-12-8 1800 700 14000 240 3.67 13 Aminocyclopyrachlor acid 2013 858956-08-8 > 60000 11000 19850 < 370 7400 > 122000 Aminocyclopyrachlor ester 2013 6500 9950 Aminopyralid 2013 150114-71-9 > 50000 1360 > 49300 102000 18000 > 88000 Amitraz 33089-61-1 170 > 1.5 17.5 1.1 Amitraz BTS 27271 33089-61-1 14200 1295 Amitraz BTS 27919 33089-61-1 33100 > 50000 Ancymidol 2014 12771-68-5 > 48200 292 Antimycin A 1397-94-0 0.0045 0.004 Arsenic Acid 2014 7778-39-4 25000 7500 9.2 > 9800 Arsenic Trioxide 2014 1327-53-3 12800 Asulam sodium 2302-17-2 > 87500 13550 180 140 Atrazine 2014 1912-24-9 2650 360 60 < 1 0.001 Azinphos methyl 86-50-0 0.18 0.055 0.08 0.036 Azoxystrobin 131860-33-8 235 147 130 44 49 3400 Benfluralin 1861-40-1 34.85 1.9 1090 15.5 > 100 Bensulide 741-58-2 360 374 290 1500 Bentazon 25057-89-0 > 50000 > 50000 4500 5350 Bentazon, sodium salt 50723-80-3 > 50000 31150 60 5350 Bifenazate 2014 149877-41-8 290 250 150 890 > 3820 Bifenazate degradate [1,1'-Biphenyl]-3,4-diol (D9472) 2014 149877-41-8 115 390 710 Bifenazate degradate 2-[4-methoxy(1,1'-biphenyl)-3- yl],1- methylethyl ester (D3598) 2014 149877-41-8 22 25.5 780 Bifenazate degradate 4-methoxybiphenyl (D1989) 2014 1 49877-41-8 125 Bifenthrin 82657-04-3 0.075 0.04 0.8 0.0013 Bioallethrin 28057-48-9 4.7 Bispyrabac sodium 2013 125401-92-5 > 51000 9200 > 49600 110000 250 12 Boric Acid Salts 10043-35-3 > 400000 66500 Boscalid 188425-85-6 1350 116 > 533 298 1340 3900 Bromacil 314-40-9 18000 3000 60500 8200 6.8 45 Bromoxynil 2014 1689-84-5 Bromoxynil Heptanoate 2014 56634-95-8 14.5 15.5 219 Bromoxynil Octanoate 2014 1689-99-2 18 5.5 2.5 51 Bromoxynil phenol 1689-84-5 1050 9610 Butylate 2008-41-5 105 5950 Cacodylate Acid 2014 75-60-5 8500 9050 30900 Captan 2014 133-06-2 13.1 16.5 4200 560 320 > 12700 Captan degradate (1,2,3,6-Tetrahydrophthalimide) 201 4 1469-48-3 > 60000 > 56500 > 181000 Captan degradate (tetrahydrophthalimic acid) 2014 > 63000 Carbaryl 63-25-2 110 6 0.85 0.5 660 1500 2.1 2.1 Carbendazim 2013 10605-21-7 Carbofuran 1563-66-2 44 5.7 1.115 0.75 Carboxin 5234-68-4 600 42200 370 670 Chlorantraniliprole 500008-45-7 > 600 110 4.9 4.5 1800 2000 Chlorfenapyr 122453-73-0 3.72 3.68 2.915 3.57 

## Aquatic Life Benchmarks for Pesticide Registration | Pesticide Science an... http://www.epa.gov/pesticide-science-and-assessing- pesticide-risks/aquat...

2 of 9 1/11/2016 5:11 PMPesticide Year Updated CAS number Fish Invertebrates Nonvascular Plants Vascular

Plants Office of Water Aquatic Life Criteria

Acute 1 Chronic2 Acute 3 Chronic4 Acute 5 Acute 6 Maximum Concentration (CMC) Continuous

Concentration (CCC) Chlorfenapyr Metabolite CL303094 . 280 Chlorfenapyr Metabolite CL303195 . 850 Chlorfenapyr Metabolite CL303267 122454-23-3 35 53.5 Chlorfenapyr Metabolite CL312094 122453-73-0 > 464 Chlorfenapyr Metabolite CL325195 122453-73-0 1050 Chlorflurenol methyl ester 2536-31-4 Chlormequat chloride 999-81-5 > 50000 8450 5000 > 207000 2800 Chloropicrin 2014 76-06-2 5.5 60 6.5 Chlorothalonil 1897-45-6 5.25 3 1.8 0.6 6.8 630 Chlorothalonil degradate (SDS-3701) . 4600 13000 33700 Chlorpyrifos 2921-88-2 0.9 0.57 0.05 0.04 140 0.083 0.041 Chlorpyrifos-methyl 5598-13-0 7 0.085

Chlorsulfuron 2014 64902-72-3 > 150000 32000 > 185000 20000 50 0.35

Chromated Arsenicals 2014 < 0.95 Clethodim 99129-21-2 7500 2850 11000 1100 Clodinafop-propargyl 2014 105512-06-9 120 > 1000 3000 > 2400 Clodinafop-propargyl Degradate (CGA-193469) 2014 114420-56-3 > 4600 2600 Clodinafop-propargyl Degradate (CGA-302371) 2014 5147 97-96-7 > 47700 > 49450 30600 Clofentezine 74115-24-5 > 7.3 6 > 40 26.2 Clomazone 81777-89-1 1450 350 2700 2200 167 30200 Clopyralid 1702-17-6 984000 56500 Clothianidin 2013 210880-92-5 > 50750 9700 11 1.1 64000 121000 Copper 7440-50-8 15.7 9.01 2.05 1.11 3.1 2300 Coumaphos 2014 56-72-4 140 11.7 0.037 0.0337 Cyanamide 420-04-2 23000 < 507 1650 100 650 2330 Cyantraniliprole 2014 736994-63-1 > 5000 10700 10.2 6.56 > 10000 12100 Cyazofamid 2013 120116-88-3 > 53.5 90.1 > 650 < 87 > 1220 Cycloate 1134-23-2 2250 1300 Cyfluthrin 2013 68359-37-5 0.034 0.01 0.0125 0.0074 > 181 Cyfluthrin, beta 2013 68359-37-5 0.034 0.145 Cyhexatin 13121-70-5 Cypermethrin 52315-07-8 0.195 0.14 0.21 0.069 Cyphenothrin 39515-40-7 0.17 0.215 Cyprodinil 121552-61-2 1205 230 16 8 2250 Cyromazine 66215-27-8 > 44850 14000 > 46400 310 Dacthal (DCPA) 1861-32-1 15000 13500 > 11000 > 11000 Daminozide 1596-84-5 224000 35500 > 99800 Dazomet 2014 533-74-4 Dazomet degradate (Methyl Isothiocyanate) 2014 556-61 -6 26.5 27.5 25 200 590 Deltamethrin 52918-63-5 0.29 0.017 0.055 0.0041 Diazinon 333-41-5 45 < 0.55 0.105 0.17 3700 0.17 0.17 Dicamba acid 1918-00-9 14000 > 50000 61 > 3250 Dicamba, dimethylamine salt 2300-66-5 488500 781500 Dicamba, sodium salt 1982-69-0 253600 17300 Dichlobenil 1194-65-6 2465 < 330 1850 560 1000 30 Dichloroprop (2,4-DP) 2013 120-36-5 Dichlorvos (DDVP) 62-73-7 91.5 5.2 0.035 0.0058 14000 Dicofol 115-32-2 26.5 4.4 70 19 > 5000 Dicrotophos 141-66-2 3150 6.35 0.99 Difenacoum 56073-07-5 32 305 320 Difenoconazole 2013 119446-68-3 405 8.7 385 5.6 98 1900 Difenzoquat methyl sulfate 43222-48-6 23250 1265 630 120 Difethialone 104653-34-1 25.5 2.2 Diflubenzuron 35367-38-5 64500 100 0.0014 0.00025 200 190 Dimethenamid 87674-68-8 3150 300 6000 1020 14 8.9 Dimethoate 60-51-5 3100 430 21.5 0.5 84 Dimethomorph 2014 110488-70-5 3100 < 341 > 5300 110

Dinotefuran 2013 165252-70-0 > 49550 > 6360 > 484150 > 95300 > 97600 > 110000 Dinotefuran degradate dn phosphate 2013 > 55300 > 100400 Dinotefuran degradate MNG 2013 > 98700 Diquat Dibromide 85-00-7 7400 122 385 < 36 9.4 0.75 Disulfoton 298-04-4 19.5 4 1.95 0.01 Disulfoton sulfone 2497-06-5 > 4600 17.5 0.14 Disulfoton sulfoxide 2497-07-6 30000 32 1.53 Dithiopyr 2013 97886-45-8 Diuron 330-54-1 200 26.4 80 200 2.4 15 Dodine 2439-10-3 285 99 8.9 7.3 0.95 Dyes + Acids

. > 48000 > 96000 > 48500 Endosulfan 115-29-7 0.05 0.11 0.3 0.01 428 0.22 0.056 Endosulfan sulfate 1031-07-8 1.9 150 Endothall (acid) 145-73-3 24500 1300 46000 < 2200 

## Aquatic Life Benchmarks for Pesticide Registration | Pesticide Science an... http://www.epa.gov/pesticide-science-and-assessing- pesticide-risks/aquat...

3 of 9 1/11/2016 5:11 PMPesticide Year Updated CAS number Fish Invertebrates Nonvascular Plants Vascular

Plants Office of Water Aquatic Life Criteria

Acute 1 Chronic2 Acute 3 Chronic4 Acute 5 Acute 6 Maximum Concentration (CMC) Continuous

Concentration (CCC) Endothall (dipotassium salt) 2164-07-0 4576 1790 31900 610 Endothall (N,N-dimethylalkylamine salt) 66330-88-9 7.5 56 6 2.3 2.3 740 EPN 2013 2104-64-5 EPTC (S-Ethyl dipropylthiocarbamate) 2014 759-94-4 7000 3250 800 1400 5600 Esbiol (s-bioallethrin) 28434-00-6 3.95 Esbiothrin 84030-86-4 4.45 Esfenvalerate 66230-04-4 0.035 0.035 0.025 0.017 Ethalfluralin 55283-68-6 16 0.4 30 24 25 Ethephon 16672-87-0 44000 15850 17000 23500 2500 Ethion 2013 563-12-2 Ethofumesate 2013 26225-79-6 8750 2560 147000 300 > 2760 Ethoprop 13194-48-4 150 24 22 0.8 8400 Etofenprox 80844-07-1 1.35 23 0.4 0.17 > 18.8 > 26 Etoxazole 2013 153233-91-1 > 150 15 3.55 0.13 ETU (common degradate of Mancozeb and Maneb) . > 251000 37320 134500 2 Fenamidone 2013 161326-34-7 370 < 8.6 24.5 12.5 70 > 880 Fenamiphos 22224-92-6 4.75 3.8 0.95 0.12 Fenarimol 60168-88-9 450 180 3400 113 100 Fenbutatin- oxide 13356-08-6 0.85 0.31 15.5 16 Fenhexamid 2014 126833-17-8 670 101 > 9400 1000 4820 > 2300 Fenitrothion 122-14-5 860 46 1.15 0.087 Fenoxaprop-p-ethyl 71283-80-2 155 22 > 529 430 > 3000 Fenoxycarb 72490-01-8 800 48 200 0.0016 Fenpropathrin 39515-41-8 1.1 0.091 0.265 0.064 Fenpyrazamine 2014 473798-59-3 2600 370 2750 340 11 1100Fenpyrazamine degradate- 2-Cyano-N-isopropyl2-(otolyl)acetamide (MCNI) 2014 > 25000 Fenpyrazamine degradate- 5-Amino-2-isopropyl-4-(o-tolyl)- 1H-pyrazol-3-one(S-2188-DC) 2014 > 44500 > 47000 32000 Fenpyrazamine degradate- 5-Amino-4-hydroxy-2-isopropyl4-(o-tolyl)pyrazol-3-one(S-2188-OH) 2014 > 48500 > 49000 55000 Fenpyroximate 2013 134098-61-6 0.22 0.11 0.8 0.56 1.9 > 190 Fenthion 55-38-9 415 7.5 2.6 0.013 400 > 2800 Fipronil 120068-37-3 41.5 6.6 0.11 0.011 140 > 100Fipronil degradate 5-amino- 1 -(2,6-dichloro4-trifluoromethylphenyl)-3-cyano-4-trifluoro-methyl

thiopyrazole (MB45950) . 41.5 6.6 1.065 0.11 140 > 100

Fipronil degradate fipronil desulfinyl (MB46513) . 10 0.59 100 10.3 140 > 100 Fipronil degradate fipronil sulfone (MB46136) . 12.5 0.67 0.36 0.037 140 > 100

Florasulam 145701-23-1 > 50000 119000 > 146000 38900 3.45 1.18

Fluazinam 2014 079622-59-6 18 0.69 90 68 1.1 Flubendiamide 272451-65-7 > 32.55 60.5 > 27.4 41.5 > 69.3 > 54.6 Fludioxonil 131341-86-1 235 19 450 < 19 70 > 1000 Flumetsulam 2014 98967-40-9 > 146500 197000 127000 111000 3.21 3.1 Flumiclorac-pentyl 87546-18-7 550 > 19000 Flumioxazin 2013 103361-09-7 1150 7.7 2750 28 0.83 0.49 Fluometuron 2164-17-2 320 110 30 220 Fluopicolide 2014 239110-15-7 174.5 151 > 850 190 < 1.4 > 3200 Fluopicolide degradate- 3-chloro-5-trifluoromethylpyridine2-carboxylic acid 2014 239110-15-7 51000 Fluopicolide degradate- BAM 2014 239110-15-7 123000 10000 92050 320000 > 10000 Fluridone 59756-60-4 2800 480 650 Fluroxypyr 69377-81-7 7150 > 50000 > 100000 Fluroxypyr MHE 81406-37-3 6600 > 54.5 60 290 > 2300 Flurprimidol 56425-91-3 8600 944 5900 2960 840 10400 Flutolanil 66332-96-5 1250 233 > 3400 530 8010 8010 Flutriafol 2013 76674-21-0 16500 4800 33550 310 460 780 Folpet 2014 133-07-3 7.5 8.8 10 Fomesafen Sodium 108731-70-0 63000 9400 188000 50000 92 210 Foramsulfuron 2014 173159-57-4 > 50000 10500 > 51250 100000 3300 0.65 Formetanate HCl 23422-53-9 1350 480 45 0.5 Fosamine Ammonium 25954-13-6 188500 762000 > 15000 > 21000 Fosthiazate 2014 98886-44-3 55500 2320 130 61 > 4510 Gamma-cyhalothrin 76703-62-3 0.0145 0.00024 > 2850 Glufosinate ammonium 2014 77182-82-2 > 156000 50000 325500 31000 72 1470 Glufosinate degradate 2-acetamido-4-methylphosphinicobutanoic acid (NAG) 2014 77182-82-2 > 50450 > 357000 Glufosinate degradate 2-methylphosphinico-acetic acid (MPA) 2014 77182-82-2 > 49450 18500 53000 > 97200 Glufosinate degradate 3-methylphosphinicopropionic acid (MPP) 2014 77182-82-2 > 50000 26000 21000 < 6430 > 1000000 > 103000 Glufosinate degradate Methylphosphinico-formic acid (MPF) 2014 77182-82-2 > 51000 > 49100 > 94800 

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4 of 9 1/11/2016 5:11 PMPesticide Year Updated CAS number Fish Invertebrates Nonvascular Plants Vascular

Plants Office of Water Aquatic Life Criteria

Acute 1 Chronic2 Acute 3 Chronic4 Acute 5 Acute 6 Maximum Concentration (CMC) Continuous

Concentration (CCC) Glyphosate 1071-83-6 21500 1800 26600 49900 12100 11900 Glyphosate degradate aminomethyl phosphoric acid (AMPA) 1066-51-9 249500 341500 Glyphosate isopropylamine salt 38641-94-0 34700 Hexaflumuron 86479-06-3 > 127.8 0.0555 Hexazinone 51235-04-2 137000 17000 75800 20000 7 37.4 Hexythiazox 2014 78587-05-0 > 60 6.1 > 120 > 120 Hydramethylnon (synonym: Pyrimidone) 2014 67485-29-4 45 570 Hymexazol 10004-44-1 > 50000 15400 40900 8800 Imazamox 114311-32-9 > 59500 > 61000 > 40 11 Imazapic acid 2013 104098-48-8 > 50000 96000 > 50000 96000 > 44.1 6.1 Imazapic ammonium 2013 Imazapyr 81334-34-1 > 50000 43100 > 50000 97100 12200 24 Imazethapyr (ammonium salt) 2013 81335-77-5 120000 500000 59200 Imazethapyr CL266858 2013 Imazethapyr CL271197 2013 Imazethapyr CL290084 2013 Imazosulfuron 2013 122548-33-8 > 34500 2900 > 45500 840 206 1.46 Imazosulfuron degradate (IPSN) 2013 11000 > 113000 Imidacloprid 138261-41-3 > 41500 1200 34.5 1.05 > 10000 Indoxacarb 2014 173584-44-6 145 150 300 75 > 110 > 84 Indoxacarb degradate (IN-JT333) 2013 12 5.5 > 14.5 3.6Indoxacarb degradate- (IN-JT333) (methyl-7-chloro2,5-dihydro -2-[[[4(trifluoromethoxy)phenyl]amino]carbonyl]indeno[1,2e] [1,3,4]oxadiazine -4a(3H)-carboxylate) 2014 12 5.5 > 14.5 3.6

indoxacarb degradate (IN-MP819) 2013 > 184 84.9 32 8 Indoxacarb degradate- (IN-MP819) (lndenol[1 ,2-e][1 ,3,4]oxadlazine-1 (2H)-carboxylic acid, 7-chloro-3,5-dlhydno2-[[[4-(triftuoromethoxy)phenyl]amino]carbonyl]-, m ethyl ester) 2014 > 184 84.9 32 8

Indoxacarb degradate (KN127) 2013 197 Iodomethane 74-88-4 665 285 Iodosulfuron-methyl-sodium 2014 144550-36-7 > 44050 10200 > 43450 9100 41 0.7 Iodosulfuron-methyl-sodium Degradate (Metsulfuron) 2014 74223-64-6 > 75000 4500 > 75000 100000 31 0.36 Ipconazole 125225-28-7 765 0.18 850 Iprodione 2014 36734-19-7 260 120 > 130 > 12640 Isoxaben 82558-50-7 > 550 400 > 650 690 > 1400 Isoxaflutole 141112-29-0 > 850 > 750 110 4.9 Isoxaflutole - rpa202248 (degradate) . > 15300 > 29800 5000 75 Kresoxim methyl 2014 143390-89-0 95 87 166 55 29.2 > 301 Kresoxim-methyl degradate (BF490-1) 2014 > 52000 > 50000 Lactofen 77501-63-4 230 1.4 2425 0.99 0.6 Lambda-cyhalothrin 91465-08-6 0.105 0.031 0.0035 0.002 > 310 Limonene 138-86-3 40000 19500 Lindane (gamma HCH) 58-89-9 0.85 2.9 0.5 54 0.95 Linuron 330-55-2 1500 5.58 60 0.09 13.7 2.5 Magnesium phosphide Malathion 2013 121-75-5 16.5 8.6 0.295 0.035 2400 > 9630 0.1 Mancozeb 8018-01-7 230 290 47 Mandipropamid 374726-62-2 220 3550 > 2500 > 7900 Maneb 12427-38-2 21 60 13.4 MCPA acid 94-74-6 300 170 MCPA DMAS 2039-46-5 48000 12000 41000 11000 160 130 MCPA EHE 29450-45-1 380 90 170 20 MCPA sodium salt 3653-48-3 > 34000 > 92000 MCPB sodium salt 6062-26-6 1950 25000 380 210 Mecoprop (MCPP)-P acid 16484-77-8 > 45500 50800 Mecoprop (MCPP)-P DMAS 66423-09-4 > 46500 14 1300 Mefenoxam 70630-17-0 > 60500 20950 100 77000 Mesosulfuron-methyl 2014 208465-21-8 > 45750 29600 > 45100 1700 2400 0.64Mesosulfuron-methyl degradate (F092944) (2-Amino4,6-dimethoxypyrimidine) 2014 48500 > 50000 24000 120000 > 100000 Mesosulfuron-methyl degradate (F147447) (6-Methanesulfonamidomethyl- 1,2-benzisothiazol-3(2H)-one 1,l dioxide) 2014 > 92000 > 90900

Mesosulfuron-methyl degradate (F160459) (Methyl 2-[3-(4- hydroxy-6-methoxypyrimidine-2- yl)ureidosulfonyl]- 4-methanesulfonamido-methyl benzoate) 2014 98000 1500

Mesosulfuron-methyl degradate (F160460) (2-[3-(4-hydroxy6-methoxypyrimidin-2-yl) ureidosulfonyl]- 4-methanesulfonamidomethyl-benzoic acid) 2014 > 94710

Mesotrione 104206-82-8 > 60000 11000 420000 180000 1900 9.8 Metalaxyl 57837-19-1 65000 9100 14000 100 140000 92000 

## Aquatic Life Benchmarks for Pesticide Registration | Pesticide Science an... http://www.epa.gov/pesticide-science-and-assessing- pesticide-risks/aquat...

5 of 9 1/11/2016 5:11 PMPesticide Year Updated CAS number Fish Invertebrates Nonvascular Plants Vascular

Plants Office of Water Aquatic Life Criteria

Acute 1 Chronic2 Acute 3 Chronic4 Acute 5 Acute 6 Maximum Concentration (CMC) Continuous

Concentration (CCC) Metaldehyde 108-62-3 34500 > 38830 Metam sodium (degradate methyl isothiocyanate (MITC)) 137-42-8 25.6 27.5 25 254 590 Metam sodium and Metam potassium degradate- Methyl isothiocyanate (MITC) 2014 137-42-8 26.5 27.5 25 200 590 Methamidophos 10265-92-6 12500 48.9 13 4.5 > 50000 Methanearsonic Acid, disodium salt DSMA 144-21-8 > 56000 76500 1500 72700 Methanearsonic Acid, sodium salt MSMA 2163-80-6 6650 38750 2800 53000 Methidathion 950-37-8 1.1 6.3 1.5 0.66 Methiocarb 2032-65-7 218 50 3.5 0.1 Methomyl 16752-77-5 160 12 2.5 0.7 Methoprene 40596-69-8 380 48 165 51 Methoxychlor 72-43-5 7.5 0.7 Methoxyfenoxide 2014 161050-58-4 > 2100 530 25 6.3 > 3400 Methyl Bromide 2014 74-83-9 1950 1300 2200 Methyl bromide degradate- bromide ion 2014 8000000 7800 29000007800 2500000 Methyl paraoxon 950-35-6 1.15 1 Methyl parathion 298-00-0 925 < 10 0.485 0.25 15000 18000 Metofluthrin 2014 240494-70-6 0.6 2.35 Metolachlor 87392-12-9 1600 30 550 1 8 21 Metribuzin 21087-64-9 21000 3000 2100 1290 8.7 130 Metsulfuron methyl 74223-64-6 > 75000 4500 > 75000 31 0.36 Mevinphos 2013 7786-34-7 Molinate 2212-67-1 105 390 170 340 220 3300 MSMA 2014 2163-80-6 > 42500 38500 5630 104000 Myclobutanil 88671-89-0 1200 980 5500 830 Nabam 2013 142-59-6 Naled 300-76-5 46 2.9 0.07 0.045 25 > 1800 Napropamide 15299-99-7 3200 1100 7150 1100 3400 Niclosamide 2014 50-65-7 15 17 56 41

Nicosulfuron 2013 111991-09-4 > 500000 > 500000 43000

Norflurazon 27314-13-2 4050 770 > 7500 1000 9.7 58.2 Novaluron 2013 116714-46-6 > 490 6.16 0.075 0.03 3549 > 75.4 Orthosulfamuron 213464-77-8 > 61000 6100 > 48650 6500 80 0.7 Oryzalin 19044-88-3 1440 220 750 358 42 > 15.4 Oxadiazon 19666-30-9 440 0.88 1090 30 5.2 41 Oxamyl 23135-22-0 2100 770 90 27 120 30000 Oxydemeton-Methyl 2014 301-12-2 365 5 95 46 > 100000 Oxyfluorfen 42874-03-3 101.5 1.3 40 13 0.29 0.35 Oxypyrimidine (diazinon degradate) 4562-27-0 > 50500 > 51000 > 109000 Oxytetracycline (hydrochloride salt) 2058-46-0 > 47450 > 51000 Paclobutrazol 2014 76738-62-0 7950 49 120 9 40800 8 Paraquat dichloride 1910-42-5 6000 < 369 600 < 36.9 0.396 71 Pebulate 1114-71-2 3150 3315 230 1800 Pendimethalin 40487-42-1 69 6.3 140 14.5 5.2 12.5 Penoxsulam 2013 219714-96-2 > 51000 10200 > 49150 2950 92 3 Pentachloroaniline (PCA) 527-20-8 28 150 Pentachlorobenzene (PCB) 608-93-5 70 80 Pentachloronitrobenzene (PCNB) 82-68-8 50 13 385 18 Pentachlorophenol (PCP) 87-86-5 47.5 25 Penthiopyrad 2013 183675-82-3 145 100 1265.5 471 1200 > 1205 Permethrin 52645-53-1 0.395 0.0515 0.0106 0.0014 68 Phorate 298-02-2 1.175 0.34 0.3 0.21 > 1300 Phosmet 2014 732-11-6 35 3.2 1 0.8 Phosphine Phthalimide (PI) 2014 85-41-6 19000 19500 Picloram Acid 1918-02-1 2750 17200 36900 Picloram Potassium Salt 2545-60-0 6500 550 34150 11800 Picloram TIPA Salt 6753-47-5 187500 Picoxystrobin 2014 117428-22-5 32.5 36 12 1 4 210 Pinoxaden 243973-20-8 10000 1200 4300 Pinoxaden (NOA 447204)

. > 60000 > 60000 95600 > 93500 Pinoxaden (NOA 497854)

. > 51500 > 960 > 50500 5800 > 100000 10000 Piperalin 3478-94-2 385 945 Piperonyl Butoxide 51-03-6 950 40 255 30 Pirimicarb 23103-98-2 14500 9.5 Pirimiphos Methyl 29232-93-7 202 180 55 1200 Polybutene 9003-29-6 Prallethrin 23031-36-9 6 3 3.1 0.65 Prodiamine 2013 29091-21-2 > 6.5 > 6.5 1.5 Profenofos 41198-08-7 7.05 2 0.465 0.2 Prohexadione Calcium 2014 127277-53-6 > 47300 > 50000 12500 > 1100 > 1200 Prometon 2014 1610-18-0 6000 19700 12850 3450 98 

## Aquatic Life Benchmarks for Pesticide Registration | Pesticide Science an... http://www.epa.gov/pesticide-science-and-assessing- pesticide-risks/aquat...

6 of 9 1/11/2016 5:11 PMPesticide Year Updated CAS number Fish Invertebrates Nonvascular Plants Vascular

Plants Office of Water Aquatic Life Criteria

Acute 1 Chronic2 Acute 3 Chronic4 Acute 5 Acute 6 Maximum Concentration (CMC) Continuous

Concentration (CCC) Prometryn 2014 7287-19-6 1455 620 4850 1000 1.04 11.9 Propachlor 1918-16-7 85 395 13.5 Propanil 709-98-8 1150 9.1 600 86 16 110 Propargite 2312-35-8 59 16 37 9 66.2 75000 Propazine 2014 139-40-2 > 2190 560 > 2660 47 24.8 100 Propetamphos 31218-83-4 94 1.65 Propiconazole 60207-90-1 425 95 650 260 21 4828 Propionic Acid 79-09-4 25500 11350 Propoxur 114-26-1 1850 5.5 Propylene Oxide 2014 75-56-9 42000 68500 > 860 > 870 Propyzamide 23950-58-5 36000 7700 > 2800 600 > 4000 1180 Pymetrozine 2014 123312-89-0 > 64000 11700 43500 25 17000 > 109000 Pyraclostrobin 175013-18-0 3.1 2.35 7.85 4 1.5 1720 Pyraflufen-ethyl 2013 129630-19-9 > 42.5 3.4 > 41 81 1.5 16 Pyrasulfotole 2013 365400-11-9 > 48000 580 > 47900 12800 8300 28 Pyrethrin 8003-34-7 2.55 1.9 5.8 0.86 Pyridaben 96489-71-3 0.36 0.087 0.265 0.044 > 665 > 16.2 Pyridalyl 179101-81-6 250 49 2.1 4.4 Pyrifluquinazon 2014 337458-27-2 1950 1.4 < 1.4 3300 Pyrifluquinazon degradate IV-01 (1,2,3,4-tetrahydro -3-[(3-pyridylmethyl)amino]-6-[1,2,2,2-tetrafluoro1-(trifluoromethyl)ethyl]quinazolin-2-one) 2014 0.7

Pyrifluquinazon degradate IV-02 (1,2,3,4-tetrahydro -3-[(3-pyridylmethyl)amino]-6-[1,2,2,2-tetrafluoro1-(trifluoromethylene)ethyl]quinazolin-2-one) 2014 0.55

Pyrifluquinazon degradate IV-203 (1,2,3,4-tetrahydro6-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]quinazolin2,4-dione) 2014 > 395

Pyrifluquinazon degradate IV-28 (4-hydroxy-3-[(pyri dine3-ylmethylene)amino]-6-[1,2,2,2-tetrafluoro1-(trifluoromethyl)ethyl]-3-4-dihydro-1H-quinazolin-2-one) 2014 1.15

Pyrimethanil 53112-28-0 5050 20 1500 1000 1800 7800 Pyriproxyfen 95737-68-1 > 162.5 4.3 200 0.015 56 > 180 Pyroxsulam 422556-08-9 > 43500 10100 > 49500 10400 111 2.57 Quinclorac 84087-01-4 15800 16000 14900 110000 > 500 > 500 Quizalofop ethyl 76578-14-8 230 11 1060 > 1770 > 82.8 Resmethrin 10453-86-8 0.14 0.32 1.55

Rimsulfuron 122931-48-0 > 195000 > 180000 > 29 11.6

Rotenone 83-79-4 0.97 1.01 1.85 1.25 Saflufenacil 2013 372137-35-4 > 54000 997 > 49000 1330 42 87 Sethoxydim 74051-80-2 85000 39050 > 281 Siduron 1982-49-6 4050 15 > 6850 6 212 212 Simazine 2014 122-34-9 3200 500 2.24 140 S-Metolachlor 87392-12-9 1600 30 550 1 8 21 S-Metolachlor degradate ESA

. 24000 > 54000 > 99450 > 95100 S-Metolachlor degradate OA

. > 46550 7700 57100 > 95100 Sodium Arsenite 2014 7784-46-5 2445 370 Sodium chlorate 7775-09-9 > 500000 460000 500000 133000 43000 Sodium cyanide 143-33-9 94 Sodium fluoroacetate 62-74-8 27000 175000 Sodium Metabisulfite 2014 7681-57-4 Sodium Tetrathiocarbonate 7345-69-9 3350 3300 17000 Sodium tetrathiocarbonate degradate carbon disulfide 75-15-0 435 430 520 Spinosad 168316-95-8 2970 498 7000 0.6 90 10600 Spirodiclofen 2013 148477-71-8 > 17.55 1.95 > 22.75 11.1 > 60 Spiromesifen 2013 283594-90-1 8.4 0.49 > 46.15 0.25 > 94 > 101.3 Spiromesifen-enol 2013 > 51000 9200 > 50500 Spirotetramat 203313-25-1 705 534 330 100 4050 4490 Spirotetramat enol degradate

. > 50000 37450 > 100000 5400 Spirotetramat keto hydroxy degradate . > 50000 Sulfentrazone 122836-35-5 46900 2950 30200 200 1.8 28.8 Sulfometuron Methyl 2014 74222-97-2 > 74000 > 75000 97000 4.3 0.45 Sulfosulfuron 141776-32-1 > 47500 100000 > 48000 102000 400 1

Sulfoxaflor 2014 946578-00-3 > 181500 660 > 200000 50500 81200 > 99000 Sulfoxaflor degradate- N-(methyl(oxido){1-[6- (trifluoromethyl) pyridin-3-yl]ethyl}- λ4-sulfanylidene) urea 2014 > 239000 > 102500 Sulfur dioxide 7446-09-5 Sumithrin (synonym: d-phenothrin) 26002-80-2 7.9 1.1 2.2 0.47 Tau-Fluvalinate 102851-06-9 0.175 0.47 0.1 Tebuconazole 107534-96-3 1135 12 1440 120 1450 151.5 Tebufenozide 112410-23-8 1500 < 48 1900 4.3 > 740 

## Aquatic Life Benchmarks for Pesticide Registration | Pesticide Science an... http://www.epa.gov/pesticide-science-and-assessing- pesticide-risks/aquat...

7 of 9 1/11/2016 5:11 PMPesticide Year Updated CAS number Fish Invertebrates Nonvascular Plants Vascular

Plants Office of Water Aquatic Life Criteria

Acute 1 Chronic2 Acute 3 Chronic4 Acute 5 Acute 6 Maximum Concentration (CMC) Continuous

Concentration (CCC) Tebupirimphos 96182-53-5 44.5 130 0.039 0.011 630 8800 Tebuthiuron 34014-18-1 53000 9300 148500 21800 50 135 Tefluthrin 2013 79538-32-2 0.03 0.004 0.035 0.008 Telone 542-75-6 540 45 70 7900 20000 Tembotrione 2013 335104-84-2 > 50000 604 24450 5100 310 5.2 Temephos 3383-96-8 1745 5 Terbacil 5902-51-2 23100 1200 32500 640 11 140 Terbufos 13071-79-9 0.385 0.64 0.1 0.03 Terbuthylazine 5915-41-3 1700 25450 Tetrachlorvinphos 961-11-5 265 0.95 510 Tetraconazole 2013 112281-77-3 1925 300 1315 190 310 Tetramethrin 7696-12-0 1.85 22.5 TFM (3-Trifluoromethyl-4-nitrophenol) 2013 88-30-2 300 1900 1200 Thiacloprid 2013 111988-49-9 12600 918 18.9 0.97 45000 > 95400 Thiacloprid amide 2013 > 39300 15600 100 Thiacloprid sulfonic acid 2013 > 47550 > 48050 > 100000 Thiamethoxam 153719-23-4 > 50000 20000 17.5 > 97000 > 90000 Thiencarbazone-methyl 317815-83-1 > 52000 4800 > 47000 3540 298 0.8 Thiobencarb 28249-77-6 280 50 1 17 770 Thiodicarb 59669-26-0 605 25 2.65 9 > 8300 Thiophanate methyl 23564-05-8 4150 2 2700 3 930 > 4700 Thiram 137-26-8 21 530 105 170.6 140 1600 Tolclofos-methyl 2014 57018-04-9 345 < 12 350 26 780 Tolclofos-methyl degradate- O-methyl O-(2,6-dichloro4-methylphenyl)hydrogen phosphorothioate(DM-TM) 2014 > 55000 > 47500 > 97000 Topramezone 2014 210631-68-8 > 14190 2930 14850 48600 19000 6.7 Topramezone primary degradate (M670H05) 2014 52650 > 50000 360 Tralkoxydim 87820-88-0 > 3750 > 87000 2100 7700 2600 Tralomethrin 66841-25-6 0.8 0.088 0.0195 0.0044 Triadimefon 2013 43121-43-3 2050 41 800 52 17000 Triallate 2303-17-5 600 38 45.5 13 120 2400 Triasulfuron 82097-50-5 > 50000 68600 > 50000 105000 Triazine DACT degradate

. > 50000 > 50000 Triazine DEA degradate

. 1000 Triazine DIA degradate

. 8500 63000 2500 Triazine HA degradate 2163-68-0 > 1500 > 2050 > 10000 Tribenuron methyl 2013 101200-48-0 > 50000 11800 360000 < 28000 22 2 Tribufos 78-48-8 122.5 3.5 3.4 1.56 148 1100 Trichlorfon 52-68-6 79 110 2.65 0.0057 Triclopyr acid 55335-06-3 58500 66450 29800 Triclopyr butoxyethyl ester (BEE) 64700-56-7 130 19 125 70 860 Triclopyr degradate (TCP) 55335-06-3 950 6700 2300 Triclopyr triethylamine (TEA) 57213-69-1 39600 > 32200 173000 25000 4100 6100 Trifloxystrobin 2014 141517-21-7 7.15 4.3 12.65 2.76 37.1 > 1930 Trifloxystrobin degradate CGA-321113 2014 141517-21-7 > 53000 > 47650 3200 77100 Trifloxysulfuron-Sodium (CGA-362622) 2014 290332-10-4 > 51500 9520 > 54000 549 6.5 0.24 Trifloxysulfuron-Sodium degradate- CGA 382997 2014 > 48350 > 49750 > 95850 Trifloxysulfuron-Sodium degradate- CGA-368732 2014 > 52000 > 59500 23000 Triflumizole 68694-11-1 290 33 700 67 140 720 Trifluralin 1582-09-8 20.5 1.14 280 2.4 7.52 43.5 Trinexapac-ethyl 2014 95266-40-3 17500 410 > 72750 2400 350 190 Triphenyltin Hydroxide (TPTH) 2014 76-87-9 3.55 0.065 5 < 0.2 14 8.3 Urea sulfate 21351-39-3 40000 11500 Vinclozolin 50471-44-8 1420 60 2000 790 < 1060 > 900 Zeta-cypermetherin 52315-07-8 0.195 0.14 0.0018 0.00059 Zinc Phosphide 1314-84-7 Ziram 137-30-4 4.85 101 24 39 67 370 Zoxamide 156052-68-5 78 3.48 > 390 39 10 19



## Footnotes

1 Benchmark = Toxicity value x LOC. For acute fish, toxicity value is generally the lowest 96-hour LC50in a standardized test (usually with rainbow trout , fathead minnow, or bluegill), and the LOC is 0.5.

2Benchmark = Toxicity value x LOC. For chronic fish , toxicity value is usually the lowest NOEAC from alife-cycle or early life stage test (usually with rainbow trout or fathead minnow), and the LOC is 1.

3 Benchmark = Toxicity value x LOC. For acute invertebrate, toxicity value is usually the lowest 48- or 96-hour EC 50or LC 50in a standardized test (usually with midge, scud, or daphnids), and the LOC is 0.5.

4Benchmark = Toxicity value x LOC. For chronic invertebrates, toxicity value is usually the lowest NOAEC from a life-cycle test with invertebrates (usually with midge, scud, or daphnids), and the LOC is 1. 

## Aquatic Life Benchmarks for Pesticide Registration | Pesticide Science an... http://www.epa.gov/pesticide-science-and-assessing- pesticide-risks/aquat...

8 of 9 1/11/2016 5:11 PMLast updated on October 23, 2015 5 Benchmark = Toxicity value x LOC. For acute nonvas cular plants, toxicity value is usually a short-term (less than 10 days) EC 50(usually with green algae or diatoms), and the LOC is 1.

6Benchmark = Toxicity value x LOC. For acute vascular plants, toxicity value is usually a short-term (less than 10 days) EC50 (usually with duckweed) andthe LOC is 1.

7 An acute-to-chronic ratio was used to calculate the chronic endpoint and benchmark, which may underestimate chronic toxicity.

8 Although the underlying acute toxicity value is greater than or equal to the chronic toxicity value, the acute benchmark is lower than the chronic benchmark because acute and chronic toxicity values were multiplied by LOC values of 0.5 and 1, respectively.

9Original toxicity values are in micrograms of acidequivalents per liter. For 2,4-D and 2,4-DB, the toxicity values selected were the lowest available values for the acid or salt forms. For MCPA, acute toxicity values werethe lowest for the acid, salt or ester forms, and chronic toxicity values were the lowest of the acidand salt forms. For Dicamba the toxicity values were the lowest of the acid or salt forms. (Selection was consistent with risk quotients in the cited USEPA references.)

10The acute toxicity values were the lowest of the acid, salt or ester forms, and the chronic toxicity values were the lowest of the acid and salt forms of triclopyr. (Selection was consistent with risk quotients in the cited USEPA reference.)

11 Toxicity values and benchmarks apply to permethrin . If monitoring data represent only the cisisomer of permethrin in water, comparison with benchmarks may underestimate potential toxicity.



### Generic footnotes

Empty cells indicate that acceptable aquatic toxicity values are not available.
Benchmarks preceded by a "greater-than" symbol (for example, >265,000) were derived from a "greater-than" value and may overestimate toxicity. Conversel y, benchmarks preceded by a "less-than" symbol (for example, <1,500) were derived from a "less-than" value and may underestimate toxicity.



## Definitions

CCC = Criterion continuous concentration

CMC = Criterion maximum concentration

EC50= 50 percent effect concentration

LC50= 50 percent lethal concentration

LOC = level of concern

NOAEC = no-observed-adverse-effects concentration
μg/L = microgram per liter

— = no benchmark available



## References

aStephan, C.E, D.I. Mount, D.J. Hanson, J.H. Gentile , G.A. Chapman, and W.A. Brungs. 1985. Guidelines f or Deriving Numerical National Water Quality Criteria for the Protection of Aquatic Organisms and Their Uses. EPA PB85-227049.

bU.S. EPA. 2004. Overview of the Ecological Risk Assessment Process in the Office of Pesticide Programs . Office of Prevention, Pesticides, and Toxic Substances. Office of Pesticide Programs. Washington, D.C. January 23, 20 04. 

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