SAT Report

PMN Number: P-11-0529

SAT Date: 8/2/2011

Print Date: 5/1/2013

Related cases:

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 3 Health: PMN substance ; Eco: intact material

2 3 Health: Incomplete incineration product ; Eco: high concern for toxicity o

incomplete incineration products to terrestrial organisms

 Persistence Bioaccum Toxicity Comments

3 31

2

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure: Health: Dermal Drinking Water Inhalation 

Ecotox: All releases to water

Fate: ;

P2Rec Comments:

Comment: No Comment

Keywords:

 Keywords: 

IRR-E,S,L

GI

MUTA 

ONCO

DEVEL

LIVER

KIDNEY

SENS

AQUATOX -A,C
LIVER

BLOOD

MALE REPRO

IMMUNO

ONCO

AQUATOX-C

Summary of Assessment:

 Fate:

Fate Summary: P-11-0529

FATE: 

log Kow = 5.28 (E) 

VP = 4.9E-4 torr at 25 C (E)

BP = 326 C (E)

H = 1.02E-5 (E)

log Koc = 5.98 (E)

log Fish BCF = 3.15 (E)

log Fish BAF = 3.18 (E) 

POTW removal (%) = 50-90 via sorption and stripping

Time for complete ultimate aerobic biodeg > mo

Sorption to soils/sediments = moderate

Volatilization half-life from a standard river = 130 hrs

Volatilization half-life from a standard lake = 66 da

Atmospheric Oxidation Half-life = 3.8 hr via OH radical

Atmospheric Oxidation Half-life = 160 hr via ozone

PBT Potential: P3B3

*CEB FATE: Migration to ground water = moderate

 Health:

 Health Summary: Absorption is poor all routes, based on physical/chemical 

properties. Expect Michael addition to the There is concern for irritation to the eye, 

skin, and lung, and for disturbances to the GI tract if ingested, based on information in the PMN 

MSDS. There also are concerns for skin and eye irritation, developmental, liver, and kidney 

toxicities, respiratory and dermal sensitization, mutagenicity, and oncogenicity from the 

 

.

For the potential degradation product, based on test data for the analog 

concerns are liver toxicity, blood toxicity, and male reproductive toxicity [rat 28-day oral 
NOAEL = 50 mg/kg, LOAEL = 150 mg/kg with liver toxicity; rat 90-day oral LOAEL = 10 

mg/kg based on decreased body weight in males at all doses and liver toxicity and anemia at 200 

mg/kg; there were toxic effects on the testes in 2 males in the 90-day oral study that were judged 

by the reviewer to be indicative of the potential for male reproductive toxicity. There is also 

concern for immunosuppression and oncogenicity based on data for 

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 0.20

daphnid 48-h LC50 0.60

green algal 96-h EC50 0.095

fish _ chronic value 0.009

daphnid _ chronic 

value

0.011

algal _ chronic 

value

0.038

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for SAR chemical 

class = MW 477; log Kow = 5.28 (EPI), ; 

pH7; 100% active ingredients and mean measured concentrations; hardness <180.0 mg/L as 

CaCO3; and TOC <2.0 mg/L;

high concern for the degradation product

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

1

SARs

SAR Class new chemicals category: 

Ecotox Category 

Ecotox Factors Comments: 

 SAT Chair: J. Kwiat