**Exhibit        31.1**

**CERTIFICATION**

| 1.     | I                  have reviewed this annual report on Form 10-K of the Company for                  the                  fiscal year ended January 31, 2006;                                                                                                                                                                                                                                                                                                                       |
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| 2.     | Based                  on my knowledge, this annual report does not contain any untrue                  statement                  of a material fact or omit to state a material fact necessary in                  order to                  make the statements made, in light of the circumstances under which                  such                  statements were made, not misleading with respect to the period                  covered by                  this report; |
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| 3.     | Based                  on my knowledge, the financial statements, and other financial                  information                  included in this report, fairly present in all material respects                  the                  financial condition, results of operations and cash flows of the                  Company                  as of, and for, the period presented in this report;                                                                     |
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| 4.     | The                  Company’s other certifying officer and I are responsible for establishing                  and maintaining disclosure controls and procedures (as defined                  in Exchange                  Act Rules 13a-14 and 15d-14) for the Company and we                  have:                                                                                                                                                                       |

| (a)  | designed                  such disclosure controls and procedures, or caused such disclosure                  controls and procedures to be designed under our supervision, to                  ensure                  that material information relating to the Company, including its                  consolidated subsidiaries, is made known to us by others within                  those                  entities, particularly during the period in which this report was                  being                  prepared; |
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| (b)  | evaluated                  the effectiveness of the Company’s disclosure controls and procedures and                  presented in this report our conclusions about the effectiveness                  of the                  disclosure controls and procedures, as of the end of the period                  covered by                  this report based on such evaluation; and                                                                                                                                          |
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| (c)  | disclosed                  in this report any change in the Company’s internal control over financial                  reporting that occurred during the Company’s most recent fiscal quarter                  that has materially affected, or is reasonably likely to materially                  affect                  the Company’s internal control over financial reporting;                  and                                                                                                          |

| 5. | The                  Company’s other certifying officer and I have disclosed, based on our most                  recent evaluation, to the Company’s auditors and the audit committee of                  the Company’s board of directors: |
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| (a)  | all                  significant deficiencies and material weaknesses in the design                  or                  operation of internal control over financial reporting which are                  reasonably likely to adversely affect the Company’s ability to record,                  process, summarize and report financial information;                  and |
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| (b)  | any                  fraud, whether or not material, that involves management or other                  employees who have a significant role in the Company’s internal control                  over financial reporting.                                                                                                                                                   |

| Dated:                  April 28, 2006 | /s/                  George G. Usher             |
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|                                   | Chief                  Executive Officer         |
|                                   | Polydex                  Pharmaceuticals Limited |

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