**EXHIBIT 10.30**

**FIRST      AMENDMENT TO THE**

**TOLL      MANUFACTURING AGREEMENT DATED SEPTEMBER 15, 2004**

**BETWEEN      GENENTECH, INC. AND WYETH**

| 1. | The                first phrase of Section 19.1.1 of the Agreement shall be replaced                with the                following phrase: “Wyeth shall not disclose or transfer (a) Genentech                Confidential Information and/or (b) Genentech Proprietary Materials                provided to Wyeth by or on behalf of Genentech under this Agreement                or                reproduced by Wyeth from other Genentech Proprietary Materials provided                to                Wyeth by or on behalf of Genentech under this Agreement to any Third                Party                other than:” |
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| 2. | The                first sentence of Section 19.4.3 of the Agreement shall be replaced                with                the following sentence: “Wyeth shall not use (a) Genentech Confidential                Information and/or (b) Genentech Proprietary Materials provided to                Wyeth                by or on behalf of Genentech under this Agreement or reproduced by                Wyeth                from other Genentech Proprietary Materials provided to Wyeth by or                on                behalf of Genentech under this Agreement for any purpose other than                performing its obligations under the Transaction Agreements, without                first                obtaining Genentech’s prior written consent to such                utilization.” |
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| 3. | The                first sentence of Section 21.9.4 of the Agreement shall be replaced                with                the following sentence: “Upon expiration or termination of this Agreement,                unless otherwise directed by Genentech, Wyeth shall, within thirty                (30)                days after such expiration or termination: (i) either destroy or                transfer                to Genentech, at Genentech’s option and expense, all quantities of Product                and all quantities of Genentech Proprietary Materials in Wyeth’s                possession that were provided to Wyeth by or on behalf of Genentech                under                this Agreement or reproduced by Wyeth from other Genentech Proprietary                Materials provided to Wyeth by or on behalf of Genentech under this                Agreement, with any such destruction to be certified in writing to                Genentech by an authorized Wyeth officer, (ii) return all Genentech                Confidential Information to Genentech, provided that Wyeth may keep                one                (1) copy of the Genentech Confidential Information and the Technology                for                its legal records, with such Confidential Information |
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| 4. | Capitalized                terms shall have the meaning assigned to them in the Agreement. Except                as                expressly and unambiguously stated herein, no other changes are made                to                the Agreement. All other terms and conditions of the Agreement shall                remain in full force and effect. The Agreement and this Amendment                constitute the entire understanding of the Parties with respect to                the                subject matter hereof and supersede any prior understanding, oral                or                written, between the Parties with respect                thereto. |
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| **GENENTECH,                INC.**                                                                                             |   | **WYETH,****acting through its Wyeth Pharmaceuticals Division**                                                                                            |
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| /s/                MARKUS GEMUEND                                                                                                   |   | /s/                CAVAN M. REDMOND                                                                                                                             |
| Markus                GemuendVice                President, Manufacturing CollaborationsDate:                December 6, 2004  |   | Cavan                M. RedmondExecutive                Vice President and General Manager, BioPharma Business UnitDate:                December 12, 2004  |

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