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|                       |                                         | Page |
|----------------------------|----------------------------------------------|------|
| SECTION      1 DEFINITIONS | 2                                            |
| 1.1                        | Account      or Participant’s Account  | 2    |
| 1.2                        | Affiliate                                    | 3    |
| 1.3                        | Alternate      Payee                         | 4    |
| 1.4                        | Beneficiary                                  | 4    |
| 1.5                        | Board      of Directors                      | 4    |
| 1.6                        | Catch-Up      Contributions                  | 4    |
| 1.7                        | Code                                         | 4    |
| 1.8                        | Committee                                    | 4    |
| 1.9                        | Company                                      | 4    |
| 1.10                       | Company      Match Contributions             | 4    |
| 1.11                       | Company      Stock                           | 5    |
| 1.12                       | Company      Stock Fund                      | 5    |
| 1.13                       | Compensation                                 | 5    |
| 1.14                       | Compensation      Limit                      | 6    |
| 1.15                       | Disability                                   | 6    |
| 1.16                       | Elective      Deferrals                      | 6    |
| 1.17                       | Eligible      Bonus                          | 6    |
| 1.18                       | Eligible      Commissions                    | 7    |
| 1.19                       | Eligible      Employee                       | 7    |
| 1.20                       | Employee                                     | 7    |
| 1.21                       | Employee      Pre-Tax Catch-Up Contributions | 7    |
| 1.22                       | Employee      Pre-Tax Contributions          | 8    |
| 1.23                       | Employer                                     | 8    |
| 1.24                       | Employer      Contributions                  | 8    |
| 1.25                       | Entry      Date                              | 8    |
| 1.26                       | ERISA                                        | 8    |
| 1.27                       | Highly      Compensated Employee or HCE      | 8    |
| 1.28                       | Investment      Funds                        | 9    |
| 1.29                       | Investment      Manager                      | 9    |
| 1.30                       | Leased      Employee                         | 9    |
| 1.31                       | Leave      of Absence                        | 10   |
| 1.32                       | 1934      Act                                | 10   |
| 1.33                       | Non-Elective      Contributions              | 10   |
| 1.34                       | Normal      Retirement Age                   | 10   |
| 1.35                       | Participant                                  | 10   |
| 1.36                       | Plan                                         | 11   |
| 1.37                       | Plan      Year                               | 11   |
| 1.38                       | Rollover      Contributions                  | 11   |
| 1.39                       | Roth      Basic Contributions                | 11   |
| 1.40                       | Roth      Catch-Up Contributions             | 11   |

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|                                                       |                                                             | Page |
|------------------------------------------------------------|------------------------------------------------------------------|------|
| 1.41                                                       | Roth      Rollover Contributions                                 | 11   |
| 1.42                                                       | Trust      Agreement                                             | 11   |
| 1.43                                                       | Trust      Fund                                                  | 11   |
| 1.44                                                       | Trustee                                                          | 12   |
| 1.45                                                       | Valuation      Date                                              | 12   |
| SECTION      2 ELIGIBILITY AND PARTICIPATION               | 12                                                               |
| 2.1                                                        | Initial      Eligibility                                         | 12   |
| 2.2                                                        | Employer      Aggregation                                        | 12   |
| 2.3                                                        | Participation                                                    | 12   |
| 2.4                                                        | Voluntary      Suspension                                        | 13   |
| 2.5                                                        | Mandatory      Suspension                                        | 14   |
| 2.6                                                        | Provision      of Information                                    | 14   |
| 2.7                                                        | Termination      of Participation                                | 14   |
| 2.8                                                        | Acquisitions                                                     | 15   |
| 2.9                                                        | Erroneous      Participation                                     | 15   |
| SECTION      3 ELECTIVE DEFERRALS                          | 15                                                               |
| 3.1                                                        | Employee      Pre-Tax Contributions and Roth Basic Contributions | 15   |
| 3.2                                                        | Catch-Up      Contributions                                      | 19   |
| 3.3                                                        | Deferral      Elections                                          | 19   |
| 3.4                                                        | Payment      of Elective Deferrals                               | 23   |
| SECTION      4 EMPLOYER CONTRIBUTIONS                      | 23                                                               |
| 4.1                                                        | Company      Match Contributions                                 | 23   |
| 4.2                                                        | Non-Elective      Contributions                                  | 26   |
| 4.3                                                        | Timing                                                           | 27   |
| 4.4                                                        | Periodic      Contributions                                      | 27   |
| 4.5                                                        | Reinstatements                                                   | 27   |
| 4.6                                                        | Profits      Not Required                                        | 27   |
| SECTION      5 ALLOCATION OF CONTRIBUTIONS AND INVESTMENTS | 27                                                               |
| 5.1                                                        | Elective      Deferrals                                          | 27   |
| 5.2                                                        | Company      Match Contributions                                 | 28   |
| 5.3                                                        | Non-Elective      Contributions                                  | 28   |
| 5.4                                                        | Investment                                                       | 29   |
| 5.5                                                        | Limitations      on Allocations                                  | 29   |
| SECTION      6 PARTICIPANT ACCOUNTS AND INVESTMENT FUNDS   | 33                                                               |
| 6.1                                                        | Participant      Accounts                                        | 33   |
| 6.2                                                        | Trust      Fund Assets                                           | 34   |
| 6.3                                                        | Investment      Funds                                            | 34   |

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|                                                                |                                                                | Page |
|---------------------------------------------------------------------|---------------------------------------------------------------------|------|
| 6.4                                                                 | Valuation      of Participants’ Accounts                      | 36   |
| 6.5                                                                 | Valuation      of Shares                                            | 36   |
| 6.6                                                                 | Statements      of Account                                          | 37   |
| 6.7                                                                 | Vesting      of Participants’ Accounts                        | 37   |
| 6.8                                                                 | Forfeitures                                                         | 37   |
| SECTION      7 DISTRIBUTIONS                                        | 37                                                                  |
| 7.1                                                                 | Events      Permitting Distribution                                 | 37   |
| 7.2                                                                 | Times      for Distribution                                         | 38   |
| 7.3                                                                 | Consent      Requirement and Immediate Distributions                | 39   |
| 7.4                                                                 | Form      of Distribution                                           | 40   |
| 7.5                                                                 | Company      Stock Restrictions                                     | 43   |
| 7.6                                                                 | Beneficiary      Designations                                       | 43   |
| 7.7                                                                 | Payments      to Minors or Incompetents                             | 44   |
| 7.8                                                                 | Undistributable      Accounts                                       | 45   |
| SECTION      8 WITHDRAWALS, LOANS AND DOMESTIC RELATIONS ORDERS     | 45                                                                  |
| 8.1                                                                 | General      Rules                                                  | 45   |
| 8.2                                                                 | Hardship      Withdrawal                                            | 46   |
| 8.3                                                                 | Age      59½ Withdrawal                                        | 48   |
| 8.4                                                                 | Withdrawal      From Company Match Account at Normal Retirement Age | 48   |
| 8.5                                                                 | Withdrawal      From Rollover Contributions Accounts                | 48   |
| 8.6                                                                 | Loans      to Participants                                          | 48   |
| 8.7                                                                 | Qualified      Domestic Relations Orders                            | 52   |
| 8.8                                                                 | Withdrawals      and Distributions Relating to Military Service     | 53   |
| SECTION      9 ADMINISTRATION OF THE PLAN                           | 54                                                                  |
| 9.1                                                                 | Plan      Administrator                                             | 54   |
| 9.2                                                                 | Committee                                                           | 54   |
| 9.3                                                                 | Actions      by Committee                                           | 54   |
| 9.4                                                                 | Powers      of Committee                                            | 55   |
| 9.5                                                                 | Fiduciary      Responsibilities                                     | 56   |
| 9.6                                                                 | Investment      Responsibilities                                    | 57   |
| 9.7                                                                 | Voting      and Tender Offer Rights in Company Stock                | 58   |
| 9.8                                                                 | Decisions      of Committee                                         | 58   |
| 9.9                                                                 | Administrative      Expenses                                        | 58   |
| 9.10                                                                | Eligibility      to Participate                                     | 58   |
| 9.11                                                                | Indemnification                                                     | 59   |
| SECTION      10 TRUST FUND, ROLLOVER CONTRIBUTIONS AND PLAN MERGERS | 59                                                                  |
| 10.1                                                                | Trust      Fund                                                     | 59   |
| 10.2                                                                | No      Diversion of Assets                                         | 60   |

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|                                                                                 |                                                               | Page   |
|--------------------------------------------------------------------------------------|--------------------------------------------------------------------|--------|
| 10.3                                                                                 | Continuing      Conditions                                         | 60     |
| 10.4                                                                                 | Change      of Investment Alternatives                             | 61     |
| 10.5                                                                                 | Rollover      Contributions                                        | 61     |
| 10.6                                                                                 | Merger      of Other Plans                                         | 63     |
| SECTION      11 MODIFICATION OR TERMINATION OF PLAN                                  | 63                                                                 |
| 11.1                                                                                 | Employers’      Obligations Limited                          | 63     |
| 11.2                                                                                 | Right      to Amend or Terminate                                   | 63     |
| 11.3                                                                                 | Effect      of Termination                                         | 64     |
| SECTION      12 TOP-HEAVY PLAN                                                       | 65                                                                 |
| 12.1                                                                                 | Top-Heavy      Plan Status                                         | 65     |
| 12.2                                                                                 | Top-Heavy      Plan Provisions                                     | 66     |
| SECTION      13 GENERAL PROVISIONS                                                   | 67                                                                 |
| 13.1                                                                                 | Plan      Information                                              | 67     |
| 13.2                                                                                 | Inalienability                                                     | 67     |
| 13.3                                                                                 | Rights      and Duties                                             | 67     |
| 13.4                                                                                 | No      Enlargement of Employment Rights                           | 68     |
| 13.5                                                                                 | Apportionment      of Duties                                       | 68     |
| 13.6                                                                                 | Merger,      Consolidation or Transfer                             | 68     |
| 13.7                                                                                 | Military      Service                                              | 69     |
| 13.8                                                                                 | Applicable      Law                                                | 70     |
| 13.9                                                                                 | Severability                                                       | 70     |
| 13.10                                                                                | Exhaustion      of Claims Procedure and Right to Bring Legal Claim | 70     |
| 13.11                                                                                | Captions                                                           | 70     |
|                                                                                 |                                                               |   |
| APPENDIX      A – Puerto Rico Supplement                                       | A-1                                                                |
| APPENDIX      B – Plan-to-Plan Transfer of Tanox, Inc. 401(k) Plan    Accounts | B-1                                                                |

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| If      the ADP for the Non-HCEParticipants      (“NHCEs’ ADP”) is: | Then      the Maximum ADP for the      HCE Participants is:                  |
|---------------------------------------------------------------------------------------|-----------------------------------------------------------------------------------|
| Less      than 2%2%      to 8%More      than 8%                                       | 2.0      x NHCEs’ ADPNHCEs’      ADP + 2%1.25      x NHCEs’ ADP |

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| If      the ACP for the Non-HCE Participants (“NHCEs’ ACP”) is: | Then      the Maximum ACP forthe      HCE Participants is                         |
|-----------------------------------------------------------------------------------|-----------------------------------------------------------------------------------|
| Less      than 2%2%      to 8%More      than 8%                                   | 2.0      x NHCEs’ ACPNHCEs’      ACP + 2%1.25      x NHCEs’ ACP |

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|   | GENENTECH,      INC. |
|--------|----------------------|
|   | By                   | /s/      TODD W. RICH |
|   | Title                | Vice      President, Development Regulatory, Medical Information, Drug Safety and      Quality Assurance |
|   | Dated                | December      18, 2008 |
|   |                 |   |
|   | And      by          | /s/      WILLIAM N. ANDERSON |
|   | Title                | Senior      Vice President, Sales and Marketing, Immunology |
|   | Dated                | December      18, 2008 |

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