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**SECOND      AMENDMENT**

**TO      THE**

**MANUFACTURING      AND SUPPLY AGREEMENT OF DECEMBER 7 2003**

**2**
**nd**

**Amendment**
**2**
**nd**

**      Amendment Effective Date**
**LB**
**Lonza      Inc**
**Lonza**
**Genentech**

**BACKGROUND**

**1**
**st**

**      Amendment**
**Agreement**

**[*]**

| **1.** | **[*]**.                Lonza hereby grants to Genentech an option to require Lonza to implement                a                project **[*]**                (as further described in **Exhibit                1**                attached hereto, the “**[*]**”).                Genentech may exercise such option by providing written notice to                Lonza at                any time during the Term. Upon Genentech’s exercise of such option, Lonza                shall use its Commercially Reasonable Best Efforts to initiate and                complete the **[*]**                Project in accordance with the requirements, costs and timelines                set forth                in Exhibit 1. |
|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| **2.** | **Adjustment                to Purchase Price for Successful Commercial Batches**.                Section 6.4.3 of the Agreement is amended to add a new subsection                (e) as                follows: |
|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

**[*]**
**[*]      **

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**[*]**

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| **3.** | **Invoicing                the Purchase Price for Successful Commercial Batches.**                Section 6.4.4 shall be amended to revise the last three sentences                of that                Section as follows: |
|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

**[*]**
**[*]**
**[*]**

**[*]**

| **4.** | **Process                Validation Batches for [*]**.                With respect to that Qualification Batch identified internally by                Lonza as                “**[*]**”,                notwithstanding Sections 6.4.2 and 6.4.3(c) of the Agreement, Lonza                and                Genentech agree that Genentech shall purchase such Batch from Lonza                for an                amount equal to **[*]**                (the “**Batch                Payment**”)                **[*]**.                Such Batch Payment and **[*]**shall                be the Purchase Price for **[*]**.                Genentech shall pay such amount within **[*]**                of the 2nd                Amendment Effective Date. |
|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| **5.** | **Milestone                Payments for Calendar Years 2005 and 2006**.                Section 6.4.3(d) is amended in entirety as                follows: |
|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------|

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| **6.** | **[*]****.**As                of the 2nd                Amendment Effective Date, Genentech and Lonza are in the process                of                gathering additional data in order to **[*]**                from Campaign **[*]**.                Lonza and Genentech agree, that with respect to such **[*]**,                Genentech shall continue to use commercially reasonable efforts to                perform                certain activities and testing as necessary, in Genentech reasonable                judgment and in conformance with the Quality Agreement, to determine                **[*]**.                Lonza and Genentech further agree: |
|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

**[*]**

**[*]**
**[*]**
**[*]**

**[*]**

| **7.** | **Rescheduling                of Campaigns**.                Notwithstanding                the Campaign, Campaign Minimum and Campaign Minimum Run schedule                listed on                Exhibit A of the Agreement (including any amendments thereof in the                1st                Amendment): |
|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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**[*]      **
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| 8. | **Invoicing                of Project Batches deemed releasable by Genentech but subject to                Regulatory Approval**. |
|----|-----------------------------------------------------------------------------------------------------------------------------------|

**[*]**
**Project      Batch**

| 9. | **Amendment                to the Manufacturing Process; Non-Conforming Bulk Drug Resulting                from such                amended Manufacturing Process**. |
|----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------|

**[*]**
**[*]**
**[*]**
**[*]**

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| GENENTECH,                INC.       |                                                                                                    |
|--------------------------------------|---------------------------------------------------------------------------------------------------------|
|                                 |                                                                                                    |   |
| By:                                  | /s/  MARKUS                GEMUEND                                                            |   |
|                                 |                                                                                                    |   |
| Name:                                | Markus                Gemuend                                                                           |   |
|                                 |                                                                                                    |   |
| Title:                               | Vice                President, Manufacturing                Collaborations & Contract Manufacturing |
|                                 |                                                                                                    |   |
|                                 |                                                                                                    |   |
| LONZA                BIOLOGICS, INC. |                                                                                                    |
|                                 |                                                                                                    |   |
| By:                                  | /s/  STEPHAN                KUTZER                                                            |   |
|                                 |                                                                                                    |   |
| Name:                                | Stephan                Kutzer                                                                           |   |
|                                 |                                                                                                    |   |
| Title:                               | Chief                Operating Officer                                                                  |   |
|                                 |                                                                                                    |   |
|                                 |                                                                                                    |   |
| LONZA                BIOLOGICS, PLC  |                                                                                                    |
|                                 |                                                                                                    |   |
| By:                                  | /s/  STEPHAN                KUTZER                                                            |   |
|                                 |                                                                                                    |   |
| Name:                                | Stephan                Kutzer                                                                           |   |
|                                 |                                                                                                    |   |
| Title:                               | Chief                Operating Officer                                                                  |   |

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**EXHIBIT      1**

**[*]      Project**

**[*]**

**1.**
**[*].**

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**[*]**

**[*]**
**[*]**

**[*]**

**1.1**
**Details      of [*]**

**[*]**
**[*]**
**[*]**
*This      change will require operations, process validation, documentation, controls      and      computer validation resources*

**[*]**
**[*]**
**[*]**
**[*]**
**[*]**
**[*]**
**[*]**
**[*]**
**[*]**
**[*]**
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**[*]**
**[*]      **
**[*]**
*This      will require operations, process validation, documentation, controls and      computer validation resources.*

**[*]**
**[*]**
**[*]**
*This      will require operations and documentation support.*

**[*]**

**2.**
**Actions/Activity      Required.**

**[*]**

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**3.**
**Schedule      **

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**4.**
**Cost      and Benefit**

**4.1**
**Costs.**

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**(a)**
**[*].      **
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**(b)**
**Reimbursement      of Costs of [*]. **
**[*]**
**[*]**
**[*]**
**[*]**
**[*]**
**[*]**
** **
**[*]**

**(c)**
**Activity      Costs. **
**[*]**
**[*]**
**[*]**
**Activity      Costs**
**[*]**
**[*]**
**[*]**
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**(d)**
**Project      Scope Changes.**
**[*]**
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**[*]**

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