### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 1 of 71 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION 

## MEMORANDUM

DATE: November 16, 2010

SUBJECT: Aggregate Dietary Assessment of the Common Metabolite/Degradate Ethylene Thiourea (ETU) to Support New Tolerances on Imported Grapes and Bananas for Metiram and for New Tolerances for Mancozeb on Almonds, Broccoli, Cabbage, Lettuce, and Peppers.

PC Codes: 600016, 14504, 14505, 14601 DP Barcode: D366141 Decision No.: 299414 Registration No.: NA Petition No.: PP# 9E6006 PP#4F4324 and 4F4333 Regulatory Action: New Tolerance Risk Assessment Type: Dietary Aggregate Case No.: NA
T XR No.: NA CAS No.: 96-45-7; 8018-01-7; 12427-38-2; 9006-42-2
MRID No.: NA 40 CFR: 180.176, 180.110, 180.217



## REVIEWER: Christine L. Olinger, Chemist
Risk Assessment Branch 7 Health Effects Division (7509P)

THROUGH: Michael S. Metzger, Chief
Risk Assessment Branch 7 Health Effects Division (7509P)

Thurston Morton, Chemist Amelia Acierto, Chemist Dietary Exposure Science Advisory Council Health Effects Division (7509P)

TO: Cynthia Giles-Parker, Chief Fungicide Branch Registration Division (7505)

Executive Summary

BASF Corporation has submitted a petition for tole rances on imported bananas and wine grapes for the fungicide metiram and Dow AgroSciences LLC has submitted petitions for tolerances on

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 2 of 71 almonds, broccoli, cabbage, lettuce, and peppers for the fungicide mancozeb. Metiram and mancozeb are in the class of ethylene bisdithio carbamate fungicides (E BDCs), which all produce the common metabolite and environmental degradat e, ethylenethiourea (ETU). Maneb is a third fungicide registered for use in the United St ates that belongs to the EBDC group, but no proposed changes in maneb residues have been a ddressed in this assessment. This memorandum reports the results of an aggreg ate dietary exposure analysis fo r ETU, resulting from existing and proposed uses of metiram, mancozeb, and maneb. The most recent dietary exposure analysis was conducted in support of the subject actions (C. Olinger, 4/17/2007, DP Barcode D 337240).
The assessment included in this memo reflects revised usage estimates and updated information on the banana residue data. Only the dietary as sessment for cancer endpoint is included in this review, as acute and chronic risks for ETU were not of concern in previous assessments. Note that the previous assessment for metiram incl uded all grape commodities, but the petitioner has amended the request to in clude only wine grapes.

Separate dietary exposure assessments were prev iously conducted for metiram (C. Olinger, DP Barcode D326753, 4/17/07 and mancozeb (C. Olinge r, DP Barcode D323878, 4/17/07). In each of these assessments, human dietary exposure an d health risk associated with the active ingredient were estimated. Also addressed in eac h of these previous assessments are the dietary exposure and risk resulting from consumpti on of ETU residues derived from each EBDC individually. ETU has been demonstrated to be a direct-acting carcinogen and has been the subject of toxicology studies from which HED ha s selected the most appropriate and sensitive toxic effects and doses to serve as the hazard co mponent of risk. The overall dietary exposure resulting from the combined sources of ETU are evaluated in this document . Field trial or monitoring data from the EBDC/ETU Market Ba sket Survey, percent cr op treated information, and extensive processing study resu lts are used for existing uses. For the proposed new uses and tolerances field trial data, pro cessing factors, projected percen t crop treated (for the proposed mancozeb new uses), and percent imported (for the proposed metiram tolerances) are used to
refine residue estimates.

Cancer Dietary Exposure Re sults and Characterization The aggregate cancer risk estimate associated with exposure to ETU from all EBDCs for food and water is 2.8 x 10 -6 

## for the general U.S. population.

The aggregate acute, chronic, and cancer asse ssments can be considered refined. Residue estimates were refined using consumer proce ssing factors (washing, cooking), commercial processing factors (winemaking, juice), percent crop treated factors (existing domestic uses only), and market basket survey (monitoring) data for several of the existing uses. Percent crop treated information was used to refine the estim ates for the proposed new uses of mancozeb. Percent crop treated information is not availa ble for the uses on imported crops (bananas and wine grapes), residue estimates were refined usin g percent imported. Crop field trial data were used for several of the existing uses as well as all of the proposed new uses, which are likely to provide higher estimates than actual exposures. The greatest contributors to the dietary exposure for the cancer assessment were leafy vegetables , Brassica vegetables, fruiting vegetables, and

water.

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## Page 3 of 71 I. Introduction

Dietary risk assessment incorporat es both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expresse d as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

HED generally expresses concern when risks ex ceed 100% of the acute or chronic PAD. For cancer risks, calculated risks greater than one in one million are ordinarily considered to be of concern. References which discuss the acute a nd chronic risk assessments in more detail are available on the EPA/pesticides web site: “A vailable Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-AUG-1999).

The current document addresses cancer exposure from ethylene thiourea (ETU). The most recent ETU aggregate dietary exposure analysis was conducted in support of this action (C. Olinger, 4/17/2007, DP Barcode D 337240).

II. Residue Information

In 1977, the Agency initiated a Special Review a nd Continued Registration of Pesticide Products containing ethylene bisdithiocarbamates (EBDCs). The need for Special Review of the EBDCs was based on evidence suggesting that the EBDC s and ethylenethiourea ( ETU), a metabolite and degradation product of these pesticides, posed potential risks to human health and the environment. In 1982, the Agency conclude d this Special Review by issuing a Final Determination (PD 4) which required risk re duction measures to prevent unreasonable adverse effects pending development and submission of additional data needed for improved risk

assessment.

In 1987, EPA issued a second Notice of Initiation of Special Revi ew of the EBDC pesticides because of health concerns caused by ETU. Th e Special Review’s Prel iminary Determination (PD 2/3) was published on 12/20/89 (54 FR 52158) and the Final Determination (PD 4) on 3/2/92 (57 FR 7484).

The EBDC tolerance expressions has been revi sed to include residues of the parent EBDC, calculated as CS 2 

## , rather than as zineb. Dietary exposure and risk assessments will continue to include residues of ethylene thiourea (ETU), a metabolite common to all EBDCs. This change allowed the Agency to harm onize its EBDC tolerance defi nitions with CODEX.

Residue Data Cancer Assessments A summary of the residue inputs can be found as an attachment to this document. BASF

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## Page 4 of 71 Corporation submitted banana and grape residue da ta, as well as grape processing data, and Dow Agrosciences submitted residue data for almonds , broccoli, cabbage, lettuce, and peppers.
Attachment 1 to this document includes a detailed description of the esti mation of the anticipated residues for the proposed new tolerances.

Chronic Anticipated Residues

Chronic anticipated residues were also calculated from field trial or monitoring data. Averages of the field trials were used for the new tolera nces, while field trial and market basket survey data were used for established uses. Additi onal information on residue inputs may be found in the following memoranda: C. Olinger, 4/17/2007, DP 337240; F. Fort, 5/26/05, 305131.

Usage Data

BEAD provided information on the percent crop treat ed (%CT) for most of the existing uses. For the proposed new metiram tolerances, percen t imported was used as a surrogate for percent crop treated as all of the proposed new tolera nces are for imported co mmodities, and percent crop treated information from the foreign uses are not available. BEAD estimated 100% imports for bananas and 20% for wine. For the chr onic analysis, the weighted average %CT was incorporated; for the acute analysis, the estima ted maximum %CT was used when appropriate. Percent crop treated information was estimat ed for the proposed new uses of mancozeb.

Additional information can be found in the docum ent, Ethylene bisdithiocarbamates [Mancozeb, Maneb, and Metiram]. Summary of Percent Crop Treated (%CT), and Justification for Use of the 1990 EBDC Market Basket Survey in Diet ary Exposure Assessments for Reregistration (Barcode Nos. D290139, D290140, and D290137, 9/4/03, C. Swartz). Screening Level Usage Analyses (SLUAs) for the existing uses of all EBDCs are attached as well. The usage information was provided in six documents fr om BEAD, which are all attached to this assessment (Attachments 2-7).

Processing Factors

The processing factors were obtained from processing studies submitted by the registrant and were compiled in a memo entitled “Reregis tration of Mancozeb, Maneb, and Metiram : Processing and Cooking Factors to be Used in the Dietary Risk Assessment”, C. Olinger, 11/5/2003, DP Barcodes D289569; D289570; D289571. Th ese factors include cooking, peeling, washing and processing factors. Wine processing data from metiram specific studies submitted in support of the petition were used as well.

III. Drinking Water Data

The Environmental Fate and Effects Division (EFE D) has provided information on the ability of the EBDCs and the degradate ETU to reach drinking water sources (Ruhman and Parker, 8/11/06, DP Barcodes D323143 and D323141). The EB DC fungicides are expected to degrade

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 5 of 71 relatively quickly in the envir onment, so the parent compounds are not expected to reach drinking water sources. EFED has estimated dr inking water concentratio ns of ETU in surface water and groundwater using monitoring data, and modeled estimates where monitoring data are not available. Accordin g to the 8/11/06 memo,

• the chronic EDWC for surface water is 0.1 ppb of ETU based on a monitoring study conducted by the EBDC Task Force;

• A range of acute EDWCs is established with a lower lim it of 0.1 ppb of ETU (based on monitoring) and an upper limit of 25.2 ppb of ETU (based on environmental fate and transport simulation modeling using the li nked EPA PRZM and EXAMS models); and

• The ground water EDWC is 0.21 ppb of ETU (b ased on a targeted monitoring study).

Water residues were incorporated in the DEEM-F CID into the food categories “water, direct, all sources” and “water, indirect, all sources.” The distribution of output s from PRZM/EXAMS was used for the acute assessment and the groundwat er EDWC was used for the chronic and cancer assessments, as these estimates provided an upper bound estimate of water exposure.

IV. DEEM-FCID TM Program and Consumption Information

ETU acute, chronic and cancer dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID TM

, Version 2.03), which incorporates consumption data from USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII), 1994-1996 and 1998. The 1994-96, 98 data are based on the reported consumption of more than 20,000 indivi duals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linke d to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/ S; baked; or wheat flour - cooke d; fresh or N/S, baked) using publicly available recipe translation files develo ped jointly by USDA/ARS and EPA. Consumption data are averaged for the entire U.S. populati on and within population subgroups for chronic exposure assessment, but are retained as indi vidual consumption events for acute exposure

assessment.

For chronic exposure assessments, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form. Th e resulting residue consumption estimate for each food/food form is summed with the residue consum ption estimates for all other food/food forms on the commodity residue list to arri ve at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

V. Toxicological Information

The HIARC evaluated the toxico logy database of ETU on February 20, 2003 and selected the

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## Page 6 of 71 doses and endpoints for risk assessment based on a variety of exposure pathways resulting from use of the EBDC fungicides (K. Farwell, TXR# 0051924, 5/28/03). These are shown in the Table 1 below.

The HED Cancer Assessment Review Committee classified ETU as a group B2 probable human carcinogen (Bill Sette, Ph.D. mem o, 4/16/90 and Albin Kocialski, Ph.D. memo, 9/26/91). The cancer slope factor for ETU, using a 3/4 sca ling factor, was determined to be 6.01 x 10 -2 

## (mg/kg/day) -1 

## based upon female mouse liver tumors in the NTP study (Bernice Fisher and Hugh Pettigrew memo, 2/24/95). The cancer slope factor for ETU is also used for the EBDC compounds, mancozeb, metiram, and maneb which are metabolized to ETU (HED Document No. 013554, 7/7/99).

Table 1. Summary of Toxicology Endpoint Selection for ETU

Exposure Scenario Point of Departure/ Uncertainty and

FQPA Safety
Factors Level of Concern for Risk Assessment Study and Toxicological Effects

Acute Dietary Females 13-50 years

age NOAEL = 5 mg/kg/day
UF A 

### = 10x
UF H 

### =10x FQPA SF= 10x [Database Uncertainty Factor ] Acute RfD = 0.005 mg/kg/day

aPAD = 0.005 mg/kg/day Developmental rat study (Khera) LOAEL = 10 mg/kg/day based on developmental defects of brain.

Acute Dietary General Population including infants/children NOAEL = N/A No appropriate endpoint from oral toxicity studies was identified.

Chronic Dietary All populations NOAEL = 0.18 mg/kg/day
UF A 

### = 10x
UF H 

### =10x FQPA SF= 10x [Database Uncertainty Factor ] Chronic RfD = 0.0002 mg/kg/day

cPAD = 0.0002 mg/kg/day Dog chronic toxicity study. LOAEL = 1.99 mg/kg/day based on thyroid toxicity.

Carcinogenicity Cancer slope factor = 0.0601 (mg/kg/day) -1 

### B2 carcinogen with low-dose extrapolation for human risk assessment based on liver tumors in female mice. Point of Departure (POD) = A data point or an estimated poin t that is derived from observed dose-response data and used to mark the beginning of extrapolation to determine risk associated with lower en vironmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A 

### = extrapolation from animal to human (intraspecies). UF H 

### = potential variation in sensitivity among members of the human population (interspecies). UF DB 

### = to account for the absence of key data (i.e., lack of a critical study). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. N/A = not applicable.

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 7 of 71 VI. Results/Discussion

Exposure and risk estimates for the ETU aggregat e cancer assessment are presented in Table 2. HED is generally concerned when the cancer risk is no longer considered negligible, generally when the risk exceeds 10 -6 

## . The results reported for food alone is 2.6 x 10 -6 

## and food and water is
2.8 x 10 -6 

## . HED conducted a commodity contribution an alysis (Attachment 12) to determine the commodities that contribute the greatest exposure.

The crop groups contributing to the greatest expo sure are listed in Table 3; the greatest
contributor to the diet ary exposure are the leafy vegetables. The commodity within the crop group leading to the most exposur e is leaf lettuce (approximately 13% of the exposure). This
assessment assumes that all leaf lettuce consumed in the US has been treated with an EBDC fungicide, either mancozeb or maneb. Other crop groups contributing more than 9% of the total exposure were the Brassica vegetables, fruiting vegetables and water.

Table 2. Results of Cancer Dietary Exposure Anal ysis for ETU from Mancozeb, Maneb, and Metiram

Population Subgroup Exposure (mg/kg/day) Estimated Cancer Risk

General U.S. Population – Food Only 0.000043 2.6 x 10 -6



### General U.S. Population – Food and Water 0.000047 2.8 x 10 -6



### Table 3. Summary of Crop Groups Contributin g Greater than 5% of Total Dietary Exposure Commodity Exposure, mg/kg bw/day Individual Cancer
Risk Percent Contribution to Total Exposure Leafy Vegetables (except Brassica) 1 

### 0.0000093 5.6 x 10 -7 

### 20

Brassica Vegetables 0.0000089 5.4 x 10 -7 

### 19 Fruiting Vegetables 0.000054 3.3 x 10 -7 

### 12 Water (direct and indirect sources) 0.0000044 2.7 x 10 -7 

### 9.4

1 

### Note that this exposure value reflects the assumption that all lettuce consumed in the US has been treated with either mancozeb or maneb.



## VII. Characterization of Inputs/Outputs

The exposure assessments can be considered refi ned. Some inputs are co nservative, while other inputs are highly refined.

• Field trial data were used for all of the proposed new tolerances and several of the existing uses. These data are generally cons idered to be conservative as samples are taken directly from the field and do not re flect any residue reduc tion that may occur during packaging and shipping. They also re flect the maximum use rates on the product label; typical use rates may be lower. Mon itoring data were used for several of the existing uses.

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 8 of 71 • Percent crop treated data were used for most of the existi ng uses of metiram, mancozeb, and maneb. However, percent crop treated information was not available for celery, ginseng, and the tropical fruits.

• Percent crop treated information are not av ailable for imported wine grapes, wine, and bananas. HED used percent imported data, so it was assumed that all bananas and wine grapes imported in the U.S. have been treate d with metiram. It is unlikely that all of these imported commodities have been treated.

• Percent crop treated – new (PCTn) data were us ed to refine the estimates for the proposed new uses of mancozeb. It is unlikely th at actual PCT for mancozeb will exceed the estimated PCTn for mancozeb on each of thes e five crops during the next five years.

• Consumer practice processing factors for pr ocedures such as washing and cooking are available and were incorporat ed into the assessment, prov iding more refined exposure
estimates.

• Residue estimates were refined using factor s reflecting commercial processing, such as wine production.

• Estimates of residues in wine for the pr oposed import tolerance for metiram were determined by applying processing factors to grape field trial data. Monitoring studies for the other EBDC fungicides on domestic wine generally found much lower residues
than the estimates used in this assessment.

• Percent crop treated data for several commod ities were not available, so it was assumed that all of these crops were treated.

VIII. Conclusions

An aggregate cancer dietary risk assessment was conducted for the metabolite ethylene thiourea resulting from the existing uses of the EBDC fu ngicides, proposed new uses of mancozeb, and proposed new import tolerances for metiram. The aggregate (food and water) cancer risk estimate associated with exposure to ETU fr om all EBDCs for food and water is 2.8 x 10 -6 

## for the general U.S. population, Although some inputs into this assessment are highly refined, other inputs are very conservative, as high-end field trial residues were used for some commodities, as well as the assumption of 100% crop treated for se veral commodities. The greatest contributors to the dietary exposure for the cancer assessme nt were leafy vegetabl es, Brassica vegetables, fruiting vegetables, and water.

VIII. List of Attachments

Attachment 1 : Estimation of Anticipated Residues for Proposed New Tolerances Attachment 2 Screening Level Usage Report for Mancozeb and Maneb Attachment 3 : Screening Level Usage Analysis for Existing Uses of Metiram Attachment 4 : Additional Percent Crop Treated Estimates for Maneb and Mancozeb Attachment 5 : Projected Percent Crop Treated (PPCT) for the Fungicide Mancozcb on Lettuce (Head, and Other).

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 9 of 71 Attachment 6 : BEAD Memo on Projected Percent Crop Treated (PPCT) with the Fungicide Mancozeb on Six New Crops: Almonds, Bell Pepper, Broccoli, Cabbage, Pumpkin, and Winter Squash, and Per cent Import Share for Mandarin Oranges Attachment 7 : BEAD Memo on Projected Percent Crop Treated for Mancozeb New Uses Percent Imported for Bananas and Grapes Attachment 8 : BEAD Memo on Percent Crop Treated for New Uses (PCTn) of Mancozeb on Almonds, Broccoli, Cabbage, Pepper, Pu mpkin, and Winter Squash and Percent Crop Treated with Maneb for Collards. Mu stard Greens, Turnip Greens, and Kale Attachment 9 . Residue Input File – ETU Cancer Analys is – Food and Water Attachment 10 . Results File – ETU Aggregate Cancer Food Only Attachment 11 . Results File – ETU Aggregate Cancer Food and Water Attachment 12 . Results File – ETU Aggregate Can cer Food and Water – Critical Commodity Contribution Analysis

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 10 of 71 Attachment 1: Estimation of Anticipa ted Residues for Proposed New Tolerances

Crop field trial data were used to estimate antic ipated residues for the proposed new tolerances for metiram on imported bananas and grapes, and the proposed new uses of mancozeb on almonds, broccoli, cabbage, lettuce, and peppers. A detailed discussion of the residue data used may be found in the residue chemistry summ ary documents (C. Olinger, DP Barcodes D289183, 4/3/07; C. Olinger, D311550 and D321530, 4/24/07; C. Olinger, DP Number 294203, 4/3/07). Processing factors for grape processed products were derived from processing studies submitted in association with the petition. Additionally, pr ocessing factors for consumer practices such as washing and cooking were used (Reregistration of Mancozeb, Maneb, and Metiram: Processing and Cooking Factors to be Used in the Dietary Risk Assessment”, C. Olinger, 11/5/2003, DP Barcodes D289569; D289570; D289571). A discussion of the anticipated residues for the proposed new tolerances for metir am and mancozeb may be found in the dietary assessments for the individual chemicals (C. Olinger, DP Barcode D326753, 4/17/07; a nd C. Olinger, D323878 and D323879, 4/17/07).

Calculation of Residue Estimates Ethylene thiourea (ETU) residues in/on raw agri cultural commodities (RAC) were adjusted for processing factors. In addition, approximately 7.5% of the EBDC consumed converts to ETU in the body; this metabolic ETU must be consider ed when estimating ETU exposure through food. Total ETU residues in foods consist of ETU in the raw or processed commodities plus the metabolic ETU from parent EB DC. EBDCs may also be conv erted to ETU during processing, usually when the process involves heating. Be low are the formulas used to calculate ETU residue estimates, including bot h conversion during processing as well as the metabolic ETU:

Raw Agricultural Commodities: [ETU]AR = [ETU]RAC + ([EBDC]RAC X 0.075 X PF1) where [ETU]AR = ETU anticipated residue estimate [ETU]RAC = ETU concentra tion as measured in the RAC [EBDC]RAC = EBDC concentration as measured in the RAC 0.075 = metabolic conversion factor PF1 = consumer processing factor (such as peeling, washing, trimming)

Processed Commodities: [ETU]AR = ([ETU]RAC X PF2) + ([EB DC]RAC X 0.075 X PF3) + ([EBDC]RAC X CF) where [ETU]AR = ETU anticipated residue estimate [ETU]RAC = ETU concentra tion as measured in the RAC PF2 = ETU processing factor (e.g. cooking) [EBDC]RAC = EBDC concentration as measured in the RAC 0.075 = metabolic conversion factor PF3 = processing factor (such as peeling, washing, trimming, cooking) CF = conversion factor for conversion of EBDC to ETU

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## Page 11 of 71

Sample Calculation: Given a raw cucumber sample bearing EBDC residues of 0.17 ppm and ETU residues of 0.02 ppm; EBDC Cooking Factor is 0.0114, ETU cooking factor is 0.87, EBDC to ETU Conversion Factor is 5.3%, and the in vivo metabolic conversion factor is 7.5 %.

EBDC Residues in Cooked Cucumber: [EBDC] raw 

### x CF = [EBDC] cooked 

### 0.17 ppm x 0.114 = 0.005 ppm

Total ETU Residues in Cooked Cucumber [ETU] AR 

### = ([ETU] RAC 

### X PF2) + ([EBDC] RAC 

### X 0.075 X PF3) + ([EBDC] RAC 

### X CF)

Loss of ETU Residues from Cooking ([ETU] RAC 

### X PF2) 0.02 ppm * 0.87 = 0.017 ppm

In vivo Conversion of EBDC residues in cooked commodity to ETU ([EBDC] RAC 

### X 0.075 X PF3) 0.17 ppm * 0.075 * 0.0114 = 0.00014

Conversion of Raw EBDC residues in Raw commodity to ETU during cooking [EBDC] RAC 

### X CF 0.17 ppm * 0.053 = 0.0089

Total ETU Residues = 0.017 + 0.00014 + 0.0089 = 0.026 ppm



## Aggregate Usage Data The general approach to combining usage inform ation for the aggregate assessment can be found in the document, Ethylene bisdithiocarbamates [Mancozeb, Maneb, and Metiram]. Summary of Percent Crop Treated (%CT), and Justification for Use of the 1990 EBDC Market Basket Survey in Dietary Exposure Assessments for Rere gistration (Barcode Nos. D290139, D290140, and D290137, 9/4/03, C. Swartz). It is assumed that a given crop will not be treated with more than one EBDC fungicide, and the percen t crop treated values are added to give the aggregate percent crop treated. However, for a few crops the perc ent crop treated, projecte d percent crop treated, and/or percent imported values add up to more than 100% aggregate percent crop treated. In such cases, the percent crop treated for the EBDC (s) showing the lowest residues were adjusted downward, or even assumed to be zero, until an aggregate percent crop treated was 100%. This adjustment may give a more conservative estimation of risk, but will ensure that the risk is not
underestimated.

Summary Table The table on the following pages provide a summ ary of the anticipated residues used in the dietary exposure assessment.Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141PC Code: 600016Page 12 of 71Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment1CommodityResidueDataSource2AverageMancozebResidue,ppmPercentCTMancozebResidueDataSource2AverageManebResidue,ppmPercentCTManebResidueDataSource2AverageMetiramResidue,ppmPercentCTMetiramChronicAnticipatedResidue 2,ppmTotal% CT3AlmondFT 0.00688 18 FT 0.007 10 0.001938 28Almond CookedFT 0.00573 18 FT 0.00613 10 0.0023893 28AppleFT 0.00562 35 FT 0.0658 1 FT 0.01 15 0.004125 51Apple, CookedFT 0.0026 35 FT 0.065 1 FT 0.0037 15 0.002115 51Apple DriedFT 0.0033 35 FT 0.066 1 FT 0.01 15 0.003315 51Apple DriedCookedFT 0.0022 35 FT 0.057 1 FT 0.0037 15 0.001895 51Apple JuiceFT 0.003 35 FT 0.067 1 FT 0.0049 15 0.002455 51Apple JuiceCookedFT 0.0022 35 FT 0.077 1 FT 0.0038 15 0.00211 51Apple SauceFT 0.0027 35 FT 0.0658 1 FT 0.01 15 0.003103 51Apple SauceCookedFT 0.0027 35 FT 0.065 1 FT 0.0037 15 0.00215 51AsparagusFT 0.006 15 0.0009 15AsparagusCookedFT 0.086 15 0.0129 15BananaFT 0.0033 85 0.0033 0 FT 0.009488 15 0.004228 100Banana CookedFT 0.0022 85 0.0022 0 FT 0.005828 15 0.002744 100Banana DriedFT 0.0033 85 0.0033 0 FT 0.007215 15 0.003887 100Banana DriedCookedFT 0.0022 85 0.0022 0 FT 0.005606 15 0.002711 100Barley, PearledBarleyFT 0.005 1 FT 0.00491 0.00005 1Barley FlourFT 0.185 1 FT 0.0189 0.00185 1Barley FlourCookedFT 0.0055 1 FT 0.00571 0.000055 1Barley BranFT 0.0085 1 FT 0.00548 0.000085 1Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141PC Code: 600016Page 13 of 71Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment1CommodityResidueDataSource2AverageMancozebResidue,ppmPercentCTMancozebResidueDataSource2AverageManebResidue,ppmPercentCTManebResidueDataSource2AverageMetiramResidue,ppmPercentCTMetiramChronicAnticipatedResidue 2,ppmTotal% CT3Bean DriedFT MBS 0.00257 1 0.0000257 1Beets, SugarFT 0.0042 2.5 FT 0.000688 1 0.00011188 3.5Belgium EndiveFT FT 0.58 100 0.58 100BroccoliFT 0.118 5 MBS 0.00457 10 0.006357 15Broccoli,CookedFT 0.0517 5 MBS 0.00283 10 0.004419 15BrusselsSproutsFT MBS 0.00457 15 0.0006855 15BrusselsSprouts CookedFT MBS 0.00283 15 0.0004245 15CabbageFT 0.061 42 MBS 0.00274 20 0.02617 62CabbageCookedFT 0.102 42 MBS 0.00244 20 0.04333 62Cabbage,ChineseFT 0.191 42 MBS 0.58 20 0.1962 62Cabbage,Chinese,CookedFT 0.544 42 MBS 0.98 20 0.4245 62CanistelFT 0.19 100 MBS 0.19 100CantaloupeFT 0.092 5 MBS 0.00632 2.5 0.004758 7.5Cantaloupe,CookedFT 0.06 5 MBS 0.013 2.5 0.003325 7.5CarrotFT 0.0078 5 0.00039 5Carrot CookedFT 0.0125 5 0.000625 5Carrot JuiceFT 0.0078 5 0.00039 5Carrot JuiceCookedFT 0.0066 5 0.00033 5CasabaFT 0.0091 5 FT 0.00632 95 0.006459 100Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141PC Code: 600016Page 14 of 71Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment1CommodityResidueDataSource2AverageMancozebResidue,ppmPercentCTMancozebResidueDataSource2AverageManebResidue,ppmPercentCTManebResidueDataSource2AverageMetiramResidue,ppmPercentCTMetiramChronicAnticipatedResidue 2,ppmTotal% CT3CauliflowerMBS 0.00457 10 0.000457 10Cauliflower,CookedMBS 0.00283 10 0.000283 10CeleryFT 0.0075 100 0.0075 100Celery CookedFT 0.0043 100 0.0043 100Celery, JuiceFT 0.0054 100 0.0054 100Celery JuiceCookedFT 0.0046 100 0.0046 100CherimoyaFT 0.0196 100 0.0196 100ChickpeaMBS 0.00257 1 0.0000257 1ChineseWaxgourdMBS 0.013 100 0.013 100ChiveFT 0.00337 100 0.00337 100Chive, CookedFT 0.00292 100 0.00292 100CollardsFT 0.324 31 0.1004 100Corn, Field,FlourMBS 0.014 1 0.00014 1Corn, FieldFlour, CookedMBS 0.0066 1 0.000066 1Corn, Field,MealMBS 0.0065 1 0.000065 1Corn, Field,BranMBS 0.0084 1 0.000084 1Corn Field BranCookedMBS 0.0066 1 0.000066 1Corn Field,StarchMBS 0.0015 1 0.000015 1Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141PC Code: 600016Page 15 of 71Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment1CommodityResidueDataSource2AverageMancozebResidue,ppmPercentCTMancozebResidueDataSource2AverageManebResidue,ppmPercentCTManebResidueDataSource2AverageMetiramResidue,ppmPercentCTMetiramChronicAnticipatedResidue 2,ppmTotal% CT3Corn FieldStarch, CookedMBS 0.0014 1 0.000014 1Corn, FieldSyrupMBS 0.0076 1 0.000076 1Corn, Field,Syrup CookedMBS 0.0061 1 0.000061 1Corn, Field, OilMBS 0.0043 1 0.000043 1Corn, PopMBS 0.0034 100 0.0034 100Corn, SweetMBS 0.00077 5 MBS 0.00408 1 0.0000793 6Corn, SweetCookedMBS 0.0004 5 MBS 0.0028 1 0.000048 6Cottonseed, OilFT 0.0012 1 FT 0.00175 10 0.000187 11CrabappleFT 0.012 100 FT 0.065 0 0.012 100CranberryFT 0.096 40 FT 0.11 5 0.0439 45CranberryCookedFT 0.044 40 FT 0.0153 5 0.018365 45Cranberry DriedFT 0.16 40 FT 0.11 5 0.0695 45Cranberry DriedCookedFT 0.064 40 FT 0.0153 5 0.026365 45Cranberry JuiceFT 0.053 40 FT 0.11 5 0.0267 45Cranberry JuiceCookedFT 0.04 40 FT 0.0146 5 0.01673 45CucumberMBS 0.0052 20 MBS 0.00632 10 0.001672 30CucumberCookedMBS 0.0052 20 MBS 0.013 10 0.00234 30EggplantMBS 0.00552 30 0.001656 30EggplantCookedMBS 0.00451 30 0.001353 30Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141PC Code: 600016Page 16 of 71Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment1CommodityResidueDataSource2AverageMancozebResidue,ppmPercentCTMancozebResidueDataSource2AverageManebResidue,ppmPercentCTManebResidueDataSource2AverageMetiramResidue,ppmPercentCTMetiramChronicAnticipatedResidue 2,ppmTotal% CT3Endive0.58 100 0.58 100Endive Cooked0.98 100 0.98 100Fennel,FlorenceFT 0.0075 100 0.0075 100FigFT 1.46 5 0.073 5Fig CookedFT 1.27 5 0.0635 5Fig, DriedFT 1.43 5 0.0715 5Fig DriedCookedFT 1.3 5 0.065 5Flaxseed OilFT 0.0055 1 FT 0.00332 10 0.000387 11GarlicMBS 0.00337 25 0.0008425 25Garlic CookedMBS 0.00292 25 0.00073 25Garlic DriedMBS 0.00376 25 0.00094 25Garlic DriedCookedMBS 0.00292 25 0.00073 25Ginseng, DriedFT 0.052 100 0.052 100GrapeFT 0.0153 5 FT 0.0212 1 FT 0.0352 0 0.000977 6Grape CookedFT 0.00867 5 FT 0.02 1 FT 0.0262 0 0.0006335 6Grape JuiceFT 0.0004 5 FT 0.0059 1 FT 0.0327 0 0.000079 6Grape JuiceCookedFT 0.0015 5 FT 0.0025 1 FT 0.0189 0 0.0001 6Grape LeavesFT 0.0153 5 FT 0.98 1 FT 0.0262 44 0.010565 6Grape RaisinFT 0.0227 5 FT 0.0267 1 FT 0.069 44 0.001402 6Grape RaisinCookedFT 0.01133 5 FT 0.0254 1 FT 0.0211 44 0.0008205 6Grape WineMON 0.0087 5 MON 0.0087 1 FT 0.0327 20 0.007062 26Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141PC Code: 600016Page 17 of 71Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment1CommodityResidueDataSource2AverageMancozebResidue,ppmPercentCTMancozebResidueDataSource2AverageManebResidue,ppmPercentCTManebResidueDataSource2AverageMetiramResidue,ppmPercentCTMetiramChronicAnticipatedResidue 2,ppmTotal% CT3Grape WineCookedMON 0.007 5 MON 0.007 1 FT 0.0189 20 0.0042 26Guar, SeedFT 0.00358 1 0.0000358 1Guar, SeedCookedFT 0.00257 1 0.0000257 1HoneydewMelonFT 0.092 5 FT 0.00632 95 0.010604 100KaleFT 0.324 73 0.2365 100KohlrabiMBS 0.00283 100 0.00283 100LeekFT 0.00337 15 0.0005055 15Leek CookedFT 0.00292 15 0.000438 15Lettuce, HeadFT 0.00842 67 MBS 0.00268 33 0.006526 100Lettuce HeadCookedFT 0.0163 67 MBS 0.00238 33 0.01171 100Lettuce LeafFT 0.191 35 FT 0.58 65 0.4438 100MangoFT 0.19 100 0.19 100Mango CookedFT 0.1 100 0.1 100Mango JuiceFT 0.12 100 0.12 100Mango JuiceCookedFT 0.098 100 0.098 100Mustard GreensFT 0.56 22 0.1232 22Oat BranFT 0.03 1 FT 0.03 10 0.0033 11Oat BranCookedFT 0.0085 1 FT 0.0085 10 0.000935 11Oat FlourFT 0.0082 1 FT 0.0082 10 0.000902 11Oat, GroatsFT 0.0081 1 FT 0.0081 10 0.000891 11Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141PC Code: 600016Page 18 of 71Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment1CommodityResidueDataSource2AverageMancozebResidue,ppmPercentCTMancozebResidueDataSource2AverageManebResidue,ppmPercentCTManebResidueDataSource2AverageMetiramResidue,ppmPercentCTMetiramChronicAnticipatedResidue 2,ppmTotal% CT3Oat, GroatsCookedFT 0.0081 1 FT 0.0081 10 0.000891 11Onion, Dry BulbMBS 0.0031 60 MBS 0.00337 15 0.0023655 75Onion, Dry BulbCookedMBS 0.0026 60 MBS 0.00292 15 0.001998 75Onion Dry Bulb,DriedMBS 0.0027 60 MBS 0.00337 15 0.0021255 75Onion Dry Bulb,Dried CookedMBS 0.0026 60 MBS 0.00292 15 0.001998 75Onion, GreenMBS 0.0031 60 MBS 0.00337 15 0.0023655 75Onion GreenCookedMBS 0.0026 60 MBS 0.00292 15 0.001998 75PapayaFT 0.19 100 0.113 0 0.19 100Papaya CookedFT 0.1 100 0.102 0 0.1 100Papaya, DriedFT 0.13 100 0.133 0 0.13 100Papaya, JuiceFT 0.12 100 0.12 0 0.12 100Papaya JuiceCookedFT 0.098 100 0.113 0 0.098 100PeanutFT 0.0058 1 FT 0.00688 1 0.0001268 2Peanut CookedFT 0.011 1 FT 0.0051 1 0.000161 2Peanut, ButterFT 0.0058 1 FT 0.00688 1 0.0001268 2Peanut, Butter,CookedFT 0.011 1 FT 0.0051 1 0.000161 2Peanut, OilFT 0.0013 1 FT 0.00556 1 0.0000686 2PearFT 0.012 35 0.0042 35Pear CookedFT 0.0053 35 0.001855 35Pear DriedFT 0.0069 35 0.002415 35Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141PC Code: 600016Page 19 of 71Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment1CommodityResidueDataSource2AverageMancozebResidue,ppmPercentCTMancozebResidueDataSource2AverageManebResidue,ppmPercentCTManebResidueDataSource2AverageMetiramResidue,ppmPercentCTMetiramChronicAnticipatedResidue 2,ppmTotal% CT3Pear DriedCookedFT 0.0044 35 0.00154 35Pepper, BellFT 0.142 44 MBS 0.00552 30 0.06414 74Pepper, BellCookedFT 0.128 44 MBS 0.00451 30 0.05767 74Pepper BellDriedFT 0.00953 44 MBS 0.00353 30 0.005252 74Pepper BellDried CookedFT 0.068 44 MBS 0.00447 30 0.03121 74Pepper NonbellFT 0.149 44 MBS 0.00552 30 0.06722 74Pepper NonbellCookedFT 0.244 44 MBS 0.00451 30 0.1087 74Pepper NonbellDriedFT 0.067 44 MBS 0.00353 30 0.03054 74Pepper NonbellDried CookedFT 0.054 44 MBS 0.00447 30 0.02510 74PlantainFT 0.0313 100 0.0148 0 0.0313 100PlantainCookedFT 0.0236 100 0.005 0 0.0236 100Plantain DriedFT 0.0236 100 0.00135 0 0.0236 100Potato ChipsMBS 0.00305 55 MBS 0.00305 2.5 FT 0.01 10 0.00275375 67.5Potato DryMBS 0.00237 55 MBS 0.00237 2.5 FT 0.0087 10 0.00223275 67.5Potato FlourMBS 0.00428 55 MBS 0.00428 2.5 FT 0.01 10 0.003461 67.5Potato FlourCookedMBS 0.00237 55 MBS 0.00237 2.5 FT 0.0087 10 0.00223275 67.5Potato TuberW/peelMBS 0.00232 55 MBS 0.00232 2.5 FT 0.0033 10 0.001664 67.5Potato TuberMBS 0.00267 55 MBS 0.00271 2.5 FT 0.0027 10 0.00180625 67.5Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141PC Code: 600016Page 20 of 71Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment1CommodityResidueDataSource2AverageMancozebResidue,ppmPercentCTMancozebResidueDataSource2AverageManebResidue,ppmPercentCTManebResidueDataSource2AverageMetiramResidue,ppmPercentCTMetiramChronicAnticipatedResidue 2,ppmTotal% CT3W/o PeelPotato, Tuber,W/o PeelCookedMBS 0.00267 55 MBS 0.00267 2.5 0.0033 10 0.00186525 67.5PumpkinMBS 0.0092 45 MBS 0.013 2.5 0.004465 47.5Pumpkin Seed MBS 0.0092 45 MBS 0.00365 2.5 0.004231 47.5Pumpkin SeedCookedMBS 0.06 45 MBS 0.00257 2.5 0.02706 47.5QuinceFT 0.012 100 0.012 100RiceFT 0.024 1 0.00024 1Rice CookedFT 0.016 1 0.00016 1Rice FlourFT 0.025 1 0.00025 1Rice FlourCookedFT 0.017 1 0.00017 1Rice BranFT 0.031 1 0.00031 1Rice BranCookedFT 0.016 1 0.00016 1Rye GrainFT 0.0081 1 FT 0.00491 10 0.000572 11Rye FlourFT 0.0081 1 FT 0.0189 10 0.001971 11Safflower, OilFT 0.0055 1 FT 0.00332 10 0.000387 11Sapote, MameyFT 0.19 100 FT 0.19 100ShallotMBS 0.00337 15 0.0005055 15Sorghum GrainFT 0.024 100 0.024 100Sorghum SyrupFT 0.016 100 0.016 100SoursopFT 0.0196 100 0.0196 100Squash,SummerMBS 0.0052 47 MBS 0.00632 10 0.003076 57Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141PC Code: 600016Page 21 of 71Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment1CommodityResidueDataSource2AverageMancozebResidue,ppmPercentCTMancozebResidueDataSource2AverageManebResidue,ppmPercentCTManebResidueDataSource2AverageMetiramResidue,ppmPercentCTMetiramChronicAnticipatedResidue 2,ppmTotal% CT3Squash,SummerCookedMBS 0.0052 47 MBS 0.013 10 0.003744 57Squash, WinterMBS 0.0092 47 MBS 0.013 10 0.005624 57Sugar AppleFT 0.0196 100 FT 0.0196 100TomatoMBS 0.00714 25 MBS 0.0076 5 0.002165 30Tomato CookedMBS 0.0078 25 MBS 0.0069 5 0.002295 30Tomato PasteMBS 0.00779 25 MBS 0.00779 5 0.002337 30Tomato PasteCookedMBS 0.00664 25 MBS 0.00664 5 0.001992 30Tomato PureeMBS 0.00454 25 MBS 0.00454 5 0.001362 30Tomato PureeCookedMBS 0.00389 25 MBS 0.00389 5 0.001167 30Tomato DriedMBS 0.00353 25 MBS 0.0066 5 0.001212 30Tomato DriedCookedMBS 0.00447 25 MBS 0.0066 5 0.0014475 30Tomato JuiceMBS 0.00257 25 MBS 0.00257 5 0.000771 30Tomato Juice,CookedMBS 0.00218 25 MBS 0.00218 5 0.000654 30Turnip TopsFT 0.56 36 0.2016 36WalnutFT 0.0059 1 FT 0.0059 35 0.002124 36Walnut CookedFT 0.0059 1 FT 0.0062 35 0.002229 36WatermelonFT 0.0091 40 FT 0.00632 5 0.003956 45WatermelonJuiceFT 0.0091 40 FT 0.00632 5 0.003956 45Wheat, GrainFT 0.016 1 FT 0.0176 10 0.00192 11Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141PC Code: 600016Page 22 of 71Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment1CommodityResidueDataSource2AverageMancozebResidue,ppmPercentCTMancozebResidueDataSource2AverageManebResidue,ppmPercentCTManebResidueDataSource2AverageMetiramResidue,ppmPercentCTMetiramChronicAnticipatedResidue 2,ppmTotal% CT3Wheat, GrainCookedFT 0.0073 1 FT 0.00491 10 0.000564 11Wheat, FlourFT 0.017 1 FT 0.0189 10 0.00206 11Wheat FlourCookedFT 0.0073 1 FT 0.00571 10 0.000644 11Wheat, GermFT 0.0076 1 FT 0.00548 10 0.000624 11Wheat BranFT 0.027 1 FT 0.0302 10 0.00329 11Wheat BranCookedFT 0.0076 1 FT 0.00548 10 0.000624 11Meat4MBS 0.000585 55 0.000585 0 0.00032175 55Meat, Cooked4MBS 0.000497 55 0.000497 0 0.00027335 55Milk4MBS 0.000595 55 0.000595 0 0.00032725 55Milk Cooked4MBS 0.000464 55 0.000464 0 0.0002552 551Usage information was obtained from the six memos attached to this memorandum as Attachments 2- 7.2FT = field trial data; MBS = Market Basket Survey Data; MON = Grape Juiceand Wine Monitoring data.3For commodities that the total percent croptreated of all three fungicides exceeds 100%, the PCT values were adjusted so thatthesum would not exceed 100%.4For meat and milk the highest percent crop treatedfor a single livestock feed +commodity was used.

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## Page 23 of 71 Attachment 2 Screening Level Usage Report for Mancozeb and Maneb

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## Page 30 of 71 Attachment 3: Screening Level Usage Analysis for Existing Uses of Metiram

Tuesday, March 22, 2005 Screening Level Estimates of Agricultural Uses of Metiram Sorted Alphabetically

**Crop Lbs. A.I. Percent Crop Ttd**

. Avg. Max. 1 Apples 500,000 15 25 2 Asparagus 1,000 <1 <2.5 3 Peaches 2,000 <1 <2.5
4 Pears <500 <1 <2.5 5 Potatoes 400,000 10 10 6 Squash <500 <1 <2.5

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## Page 31 of 71 Attachment 4: Additional Percent Crop Treated Estimates for Maneb and Mancozeb

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## Page 33 of 71 Attachment 5: Projected Percen t Crop Treated (PPCT) for the Fungicide Mancozeb on Lettuce (Head, and Other).

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## Page 37 of 71 Attachment 6: BEAD Memo on Pr ojected Percent Crop Treated (PPCT) with the Fungicide Mancozeb on Six New Crops: Almonds, Bell Pe pper, Broccoli, Cabbage, Pumpkin, and Winter Squash, and Percent Import Share for Mandarin Oranges

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## Page 44 of 71 Attachment 7: BEAD Memo on Pr ojected Percent Crop Treated fo r Mancozeb New Uses Percent Imported for Bananas and Grapes

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## Page 47 of 71 Attachment 8: BEAD Memo on Percent Crop Trea ted for New Uses (PCTn) of Mancozeb on Almonds, Broccoli, Cabbage, Pepper, Pumpkin, and Winter Squash and Percent Crop Treated with Maneb for Collards. Mustard Greens, Turnip Greens, and Kale

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## Page 56 of 71 Attachment 9: Residue Input File – ETU Cancer Analysis – Food and Water Filename: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Dietary2009\ETUAggregate2009\aggregateETUchronicpria2009foodandwater_10_18_10_new_leafy brassicas_metiram wine grapes onlyceleryincluded.R98 Chemical: ETU - Aggregate - Chronic RfD(Chronic): .0002 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .005 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0601 Date created/last modified: 10-18-2010/09:45:13/8 Program ver. 2.03 Comment: celery included; Use 9/16/10 pct for leafy brassicas and other new uses; metiram wine grapes only

-------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis: Index Dist Parameter #1 Param #2 Param #3 Comment # Code

----- ---- ------------ -------- -------- ------- 1 6 ETUapples.rdf 2 6 ETUpotato.rdf

Note: No residue distributions have been assigned to Commodities/FoodForms below

EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 14000030 14 Almond 14000031 14 Almond-babyfood 0.001640 1.000 1.000 Last e Full comment: Last edited 7/30/10 14000040 14 Almond, oil 0.001640 1.000 1.000 Last e Full comment: Last edited 7/30/10 14000041 14 Almond, oil-babyfood 0.001640 1.000 1.000 Last e Full comment: Last edited 7/30/10 11000070 11 Apple, fruit with peel 11000080 11 Apple, peeled fruit 11000081 11 Apple, peeled fruit-babyfood 0.002120 1.000 1.000 Last e Full comment: Last edited 6/9/09 11000090 11 Apple, dried 11000091 11 Apple, dried-babyfood 11000100 11 Apple, juice 11000101 11 Apple, juice-babyfood 11000110 11 Apple, sauce 11000111 11 Apple, sauce-babyfood 0.002150 1.000 1.000 Last e Full comment: Last edited 5/1/09 95000190 O Asparagus
95000230 O Banana 95000231 O Banana-babyfood 95000240 O Banana, dried 95000241 O Banana, dried-babyfood 15000250 15 Barley, pearled barley 0.000050 1.000 1.000 Last e Full comment: Last edited 5/1/09 15000251 15 Barley, pearled barley-babyfood 0.000050 1.000 1.000 Last e Full comment: Last edited 5/1/09 15000260 15 Barley, flour 15000261 15 Barley, flour-babyfood 15000270 15 Barley, bran 0.000085 1.000 1.000 Last e Full comment: Last edited 5/1/09 06030300 6C Bean, black, seed 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 06030320 6C Bean, broad, seed 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 06030340 6C Bean, cowpea, seed 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 06030350 6C Bean, great northern, seed 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 57 of 71 06030360 6C Bean, kidney, seed 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 06030380 6C Bean, lima, seed 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 06030390 6C Bean, mung, seed 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 06030400 6C Bean, navy, seed 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 06030410 6C Bean, pink, seed 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 06030420 6C Bean, pinto, seed 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 21000440 M Beef, meat 21000441 M Beef, meat-babyfood 21000450 M Beef, meat, dried 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 21000460 M Beef, meat byproducts 21000461 M Beef, meat byproducts-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 21000470 M Beef, fat 21000471 M Beef,fat-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 21000480 M Beef, kidney 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 21000490 M Beef, liver 21000491 M Beef, liver-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 01010520 1A Beet, sugar 0.000112 1.000 1.000 Last e Full comment: Last edited 5/1/09 01010521 1A Beet, sugar-babyfood 0.000112 1.000 1.000 Last e Full comment: Last edited 5/1/09 01010530 1A Beet, sugar, molasses 0.000112 1.000 1.000 Last e Full comment: Last edited 5/1/09 01010531 1A Beet, sugar, molasses-babyfood 0.000112 1.000 1.000 Last e Full comment: Last edited 5/1/09 95000540 O Belgium endive 0.580000 1.000 1.000 Last e Full comment: Last edited 5/1/09
05010610 5A Broccoli 05010611 5A Broccoli-babyfood 0.002870 1.000 1.000 Last e Full comment: Last edited 10/18/10 05010640 5A Brussels sprouts 05010690 5A Cabbage 05020700 5B Cabbage, Chinese, bok choy 05010710 5A Cabbage, Chinese, napa 05010720 5A Cabbage, Chinese, mustard
95000740 O Canistel 0.190000 1.000 1.000 Last e Full comment: Last edited 5/1/09 09010750 9A Cantaloupe
01010780 1AB Carrot 01010781 1AB Carrot-babyfood 01010790 1AB Carrot, juice

09010800 9A Casaba 0.006460 1.000 1.000 Last e Full comment: Last edited 6/12/09
05010830 5A Cauliflower 04020850 4B Celery 04020851 4B Celery-babyfood 04020860 4B Celery, juice 95000890 O Cherimoya 0.019600 1.000 1.000 Last e Full comment: Last edited 5/1/09 40000930 P Chicken, meat 40000931 P Chicken, meat-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 40000940 P Chicken, liver 0.000270 1.000 1.000 Last e

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 58 of 71 Full comment: Last edited 5/1/09 40000950 P Chicken, meat byproducts 40000951 P Chicken, meat byproducts-babyfoo 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 40000960 P Chicken, fat 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 40000961 P Chicken, fat-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 40000970 P Chicken, skin 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 40000971 P Chicken, skin-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 06030980 6C Chickpea, seed 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 06030981 6C Chickpea, seed-babyfood 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 06030990 6C Chickpea, flour 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 09021020 9B Chinese waxgourd 0.013000 1.000 1.000 Last e Full comment: Last edited 6/9/09
19011030 19A Chive

05021170 5B Collards 0.100000 1.000 1.000 Last e Full comment: Last edited 10/18/10 15001200 15 Corn, field, flour 15001201 15 Corn, field, flour-babyfood 15001210 15 Corn, field, meal 0.000065 1.000 1.000 Last e Full comment: Last edited 5/1/09 15001211 15 Corn, field, meal-babyfood 0.000065 1.000 1.000 Last e Full comment: Last edited 5/1/09 15001220 15 Corn, field, bran 15001230 15 Corn, field, starch 15001231 15 Corn, field, starch-babyfood 15001240 15 Corn, field, syrup 15001241 15 Corn, field, syrup-babyfood 15001250 15 Corn, field, oil 0.000043 1.000 1.000 Last e Full comment: Last edited 5/1/09 15001251 15 Corn, field, oil-babyfood 0.000043 1.000 1.000 Last e Full comment: Last edited 5/1/09 15001260 15 Corn, pop 0.003400 1.000 1.000 Last e Full comment: Last edited 5/1/09 15001270 15 Corn, sweet 15001271 15 Corn, sweet-babyfood 0.000048 1.000 1.000 Last e Full comment: Last edited 5/1/09 95001280 O Cottonseed, oil 0.000187 1.000 1.000 Last e Full comment: Last edited 6/9/09 95001281 O Cottonseed, oil-babyfood 0.000187 1.000 1.000 Last e Full comment: Last edited 6/9/09 11001290 11 Crabapple 0.012000 1.000 1.000 Last e Full comment: Last edited 5/1/09 95001300 O Cranberry 95001301 O Cranberry-babyfood 0.018400 1.000 1.000 Last e Full comment: Last edited 6/9/09 95001310 O Cranberry, dried 95001320 O Cranberry, juice 95001321 O Cranberry, juice-babyfood 0.016700 1.000 1.000 Last e Full comment: Last edited 6/9/09

09021350 9B Cucumber 70001450 P Egg, whole 70001451 P Egg, whole-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 70001460 P Egg, white 70001461 P Egg, white (solids)-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 59 of 71 70001470 P Egg, yolk 70001471 P Egg, yolk-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 08001480 8 Eggplant 04011500 4A Endive 04021520 4B Fennel, Florence 0.007500 1.000 1.000 Last e Full comment: Last edited 10/18/10 95001530 O Fig 95001540 O Fig, dried 20001630 20 Flaxseed, oil 0.000387 1.000 1.000 Last e Full comment: Last edited 6/9/09
03001640 3 Garlic 03001650 3 Garlic, dried 03001651 3 Garlic, dried-babyfood 0.000730 1.000 1.000 Last e Full comment: Last edited 5/1/09 01011680 1AB Ginseng, dried 0.052000 1.000 1.000 Last e Full comment: Last edited 5/1/09 23001690 M Goat, meat 0.000270 1.000 1.000 23001700 M Goat, meat byproducts 0.000270 1.000 1.000 23001710 M Goat, fat 0.000270 1.000 1.000 23001720 M Goat, kidney 0.000270 1.000 1.000 23001730 M Goat, liver 0.000270 1.000 1.000 95001750 O Grape 95001760 O Grape, juice 95001761 O Grape, juice-babyfood 0.000100 1.000 1.000 Last e Full comment: Last edited 7/30/10 95001770 O Grape, leaves 0.010600 1.000 1.000 Last e Full comment: Last edited 7/30/10 95001780 O Grape, raisin 95001790 O Grape, wine and sherry 06031820 6C Guar, seed 09011870 9A Honeydew melon 0.010600 1.000 1.000 Last e Full comment: Last edited 6/10/09

05021940 5B Kale 0.237000 1.000 1.000 Last e Full comment: Last edited 7/30/10
05011960 5A Kohlrabi 0.002830 1.000 1.000 Last e Full comment: Last edited 6/10/09

03001980 3 Leek 06032030 6C Lentil, seed 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 04012040 4A Lettuce, head 04012050 4A Lettuce, leaf 0.444000 1.000 1.000 Last e Full comment: Last edited 7/30/10 95002150 O Mango 95002151 O Mango-babyfood 0.100000 1.000 1.000 Last e Full comment: Last edited 5/1/09 95002160 O Mango, dried 0.100000 1.000 1.000 Last e Full comment: Last edited 5/1/09 95002170 O Mango, juice 95002171 O Mango, juice-babyfood 0.098000 1.000 1.000 Last e Full comment: Last edited 5/1/09 27002220 D Milk, fat 27002221 D Milk, fat - baby food/infant for 0.000260 1.000 1.000 Last e Full comment: Last edited 5/1/09 27012230 D Milk, nonfat solids 0.000260 1.000 1.000 Last e Full comment: Last edited 5/1/09 27012231 D Milk, nonfat solids-baby food/in 27022240 D Milk, water 0.000260 1.000 1.000 Last e Full comment: Last edited 5/1/09 27022241 D Milk, water-babyfood/infant form 0.000260 1.000 1.000 Last e Full comment: Last edited 5/1/09 27032251 D Milk, sugar (lactose)-baby food/ 0.000260 1.000 1.000 Last e Full comment: Last edited 5/1/09

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 60 of 71 05022290 5B Mustard greens 0.123000 1.000 1.000 Last e Full comment: Last edited 7/30/10 15002310 15 Oat, bran 15002320 15 Oat, flour 15002321 15 Oat, flour-babyfood 0.000902 1.000 1.000 Last e Full comment: Last edited 6/10/09 15002330 15 Oat, groats/rolled oats 15002331 15 Oat, groats/rolled oats-babyfood 0.000891 1.000 1.000 Last e Full comment: Last edited 6/10/09 03002370 3 Onion, dry bulb 03002371 3 Onion, dry bulb-babyfood 0.002000 1.000 1.000 Last e Full comment: Last edited 5/1/09 03002380 3 Onion, dry bulb, dried 03002381 3 Onion, dry bulb, dried-babyfood 03002390 3 Onion, green 95002450 O Papaya 95002451 O Papaya-babyfood 0.100000 1.000 1.000 Last e Full comment: Last edited 5/1/09 95002460 O Papaya, dried 0.130000 1.000 1.000 Last e Full comment: Last edited 5/1/09 95002470 O Papaya, juice 06032560 6C Pea, dry 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 06032561 6C Pea, dry-babyfood 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09 06032580 6C Pea, pigeon, seed 0.000026 1.000 1.000 Last e Full comment: Last edited 5/1/09

95002630 O Peanut 95002640 O Peanut, butter 95002650 O Peanut, oil 0.000070 1.000 1.000 Last e Full comment: Last edited 5/1/09

11002660 11 Pear 11002661 11 Pear-babyfood 0.001860 1.000 1.000 Last e Full comment: Last edited 5/1/09 11002670 11 Pear, dried 11002680 11 Pear, juice 11002681 11 Pear, juice-babyfood 0.002100 1.000 1.000 Last e Full comment: Last edited 5/1/09 08002700 8 Pepper, bell 08002701 8 Pepper, bell-babyfood 0.057700 1.000 1.000 Last e Full comment: Last edited 10/18/10 08002710 8 Pepper, bell, dried 08002711 8 Pepper, bell, dried-babyfood 0.031300 1.000 1.000 Last e Full comment: Last edited 10/18/10 08002720 8 Pepper, nonbell 08002721 8 Pepper, nonbell-babyfood 0.109000 1.000 1.000 Last e Full comment: Last edited 10/18/10 08002730 8 Pepper, nonbell, dried
95002830 O Plantain 95002840 O Plantain, dried 0.023600 1.000 1.000 Last e Full comment: Last edited 5/1/09 25002900 M Pork, meat 25002901 M Pork, meat-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 25002910 M Pork, skin 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 25002920 M Pork, meat byproducts 25002921 M Pork, meat byproducts-babyfood 0.001000 1.000 1.000 Last e Full comment: Last edited 5/1/09 25002930 M Pork, fat 25002931 M Pork, fat-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 25002940 M Pork, kidney 0.000270 1.000 1.000 Last e

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 61 of 71 Full comment: Last edited 5/1/09 25002950 M Pork, liver 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 01032960 1C Potato, chips 0.002750 1.000 1.000 Last e Full comment: Last edited 6/10/09 01032970 1C Potato, dry (granules/ flakes) 0.002230 1.000 1.000 Last e Full comment: Last edited 6/10/09 01032971 1C Potato, dry (granules/ flakes)-b 0.002230 1.000 1.000 Last e Full comment: Last edited 6/10/09 01032980 1C Potato, flour 01032981 1C Potato, flour-babyfood 01032990 1C Potato, tuber, w/peel 0.001660 1.000 1.000 Last e Full comment: Last edited 5/1/09 01032991 1C Potato, tuber, w/peel-babyfood 0.001660 1.000 1.000 Last e Full comment: Last edited 5/1/09 01033000 1C Potato, tuber, w/o peel 01033001 1C Potato, tuber, w/o peel-babyfood 0.001870 1.000 1.000 Last e Full comment: Last edited 5/1/09 60003010 P Poultry, other, meat 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 60003020 P Poultry, other, liver 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 60003030 P Poultry, other, meat byproducts 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 60003040 P Poultry, other, fat 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 60003050 P Poultry, other, skin 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 09023080 9B Pumpkin 0.004460 1.000 1.000 Last e Full comment: Last edited 10/18/10 09023090 9B Pumpkin, seed 11003100 11 Quince 0.012000 1.000 1.000 Last e Full comment: Last edited 5/1/09 15003230 15 Rice, white 15003231 15 Rice, white-babyfood 0.000160 1.000 1.000 Last e Full comment: Last edited 5/1/09 15003240 15 Rice, brown 15003241 15 Rice, brown-babyfood 15003250 15 Rice, flour 15003251 15 Rice, flour-babyfood 15003260 15 Rice, bran 15003261 15 Rice, bran-babyfood 0.000160 1.000 1.000 Last e Full comment: Last edited 5/1/09 15003280 15 Rye, grain 0.000572 1.000 1.000 Last e Full comment: Last edited 6/10/09 15003290 15 Rye, flour 0.001970 1.000 1.000 Last e Full comment: Last edited 6/10/09 20003300 20 Safflower, oil 0.000387 1.000 1.000 Last e Full comment: Last edited 6/10/09 20003301 20 Safflower, oil-babyfood 0.000387 1.000 1.000 Last e Full comment: Last edited 6/10/09 95003330 O Sapote, Mamey 0.190000 1.000 1.000 Last e Full comment: Last edited 5/1/09
03003380 3 Shallot 0.000506 1.000 1.000 Last e Full comment: Last edited 5/1/09 26003390 M Sheep, meat 26003391 M Sheep, meat-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 26003400 M Sheep, meat byproducts 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 26003410 M Sheep, fat 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 26003411 M Sheep, fat-babyfood 0.000270 1.000 1.000 Last e

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 62 of 71 Full comment: Last edited 5/1/09 26003420 M Sheep, kidney 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 26003430 M Sheep, liver 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 15003440 15 Sorghum, grain 0.024000 1.000 1.000 Last e Full comment: Last edited 5/1/09 15003450 15 Sorghum, syrup 0.016000 1.000 1.000 Last e Full comment: Last edited 5/1/09 95003460 O Soursop 0.019600 1.000 1.000 Last e Full comment: Last edited 5/1/09 09023560 9B Squash, summer 09023561 9B Squash, summer-babyfood 0.003740 1.000 1.000 Last e Full comment: Last edited 10/18/10 09023570 9B Squash, winter 0.005620 1.000 1.000 Last e Full comment: Last edited 10/18/10 09023571 9B Squash, winter-babyfood 0.005620 1.000 1.000 Last e Full comment: Last edited 10/18/10
95003580 O Starfruit 0.190000 1.000 1.000 Last e Full comment: Last edited 5/1/09 95003610 O Sugar apple 0.020000 1.000 1.000 Last e Full comment: Last edited 5/1/09

08003750 8 Tomato 08003751 8 Tomato-babyfood 0.002300 1.000 1.000 Last e Full comment: Last edited 5/1/09 08003760 8 Tomato, paste 08003761 8 Tomato, paste-babyfood 0.002000 1.000 1.000 Last e Full comment: Last edited 5/1/09 08003770 8 Tomato, puree 08003771 8 Tomato, puree-babyfood 0.001170 1.000 1.000 Last e Full comment: Last edited 5/1/09 08003780 8 Tomato, dried 08003781 8 Tomato, dried-babyfood 0.001450 1.000 1.000 Last e Full comment: Last edited 5/1/09 08003790 8 Tomato, juice 50003820 P Turkey, meat 50003821 P Turkey, meat-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 50003830 P Turkey, liver 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 50003831 P Turkey, liver-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 50003840 P Turkey, meat byproducts 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 50003841 P Turkey, meat byproducts-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 50003850 P Turkey, fat 50003851 P Turkey, fat-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 50003860 P Turkey, skin 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 50003861 P Turkey, skin-babyfood 0.000270 1.000 1.000 Last e Full comment: Last edited 5/1/09 05023890 5B Turnip, greens 0.202000 1.000 1.000 Last e Full comment: Last edited 7/30/10

14003910 14 Walnut 86010000 O Water, direct, all sources 0.000210 1.000 1.000 Last e Full comment: Last edited 5/1/09 86020000 O Water, indirect, all sources 0.000210 1.000 1.000 Last e Full comment: Last edited 5/1/09

09013990 9A Watermelon 0.003960 1.000 1.000 Last e Full comment: Last edited 5/1/09 09014000 9A Watermelon, juice 0.003960 1.000 1.000 Last e

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 63 of 71 Full comment: Last edited 5/1/09 15004010 15 Wheat, grain 15004011 15 Wheat, grain-babyfood 15004020 15 Wheat, flour 15004021 15 Wheat, flour-babyfood 15004030 15 Wheat, germ 0.000624 1.000 1.000 Last e Full comment: Last edited 6/10/09 15004040 15 Wheat, bran

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 64 of 71 Attachment 10. Results File – ETU Aggregate Cancer Food Only

U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for ETU - AGGREGATE - CHRONIC (1994-98 data) Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Dietary2009\ETUAggregate2009\aggregateETUchronicpria2009foodalone_10_18_10_new_leafybra ssicas_metiram wine grapes onlyceleryincluded.R98 Adjustment factor #2 used. Analysis Date 10-18-2010/11:21:20 Residue file dated: 10-18-2010/11:19:07/8 Q* = 0.0601 COMMENT 1: celery included; Use 9/16/10 pct for leafy brassicas and other new uses; metiram wine grapes only

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Lifetime risk Subgroup body wt/day (Q*= .0601)

-------------------------------------- ------------- ------------- U.S. Population (total) 0.000043 2.56E-06

U.S. Population (spring season) 0.000045 2.69E-06 U.S. Population (summer season) 0.000044 2.62E-06 U.S. Population (autumn season) 0.000041 2.44E-06 U.S. Population (winter season) 0.000041 2.49E-06

Northeast region 0.000047 2.82E-06 Midwest region 0.000036 2.13E-06 Southern region 0.000038 2.27E-06 Western region 0.000054 3.23E-06

Hispanics 0.000048 2.86E-06 Non-hispanic whites 0.000038 2.27E-06 Non-hispanic blacks 0.000048 2.89E-06 Non-hisp/non-white/non-black 0.000093 5.56E-06

All infants (< 1 year) 0.000037 2.22E-06 Nursing infants 0.000020 1.18E-06 Non-nursing infants 0.000044 2.62E-06 Children 1-6 yrs 0.000075 4.48E-06 Children 7-12 yrs 0.000039 2.36E-06

Females 13-19 (not preg or nursing) 0.000028 1.67E-06 Females 20+ (not preg or nursing) 0.000042 2.50E-06 Females 13-50 yrs 0.000041 2.43E-06 Females 13+ (preg/not nursing) 0.000104 6.23E-06 Females 13+ (nursing) 0.000025 1.51E-06

Males 13-19 yrs 0.000035 2.11E-06 Males 20+ yrs 0.000038 2.28E-06 Seniors 55+ 0.000043 2.59E-06

Children 1-2 yrs 0.000088 5.29E-06 Children 3-5 yrs 0.000072 4.30E-06 Children 6-12 yrs 0.000042 2.53E-06 Youth 13-19 yrs 0.000032 1.90E-06 Adults 20-49 yrs 0.000039 2.32E-06 Adults 50+ yrs 0.000043 2.61E-06 Females 13-49 yrs 0.000039 2.35E-06

-------------------------------------------------------------------------------

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 65 of 71

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 66 of 71 Attachment 11. Results File – ETU Aggregate Cancer Food and Water

U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for ETU - AGGREGATE - CHRONIC (1994-98 data) Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Dietary2009\ETUAggregate2009\aggregateETUchronicpria2009foodandwater_10_18_10_new_leafy brassicas_metiram wine grapes onlyceleryincluded.R98 Adjustment factor #2 used. Analysis Date 10-18-2010/09:46:10 Residue file dated: 10-18-2010/09:45:13/8 Q* = 0.0601 COMMENT 1: celery included; Use 9/16/10 pct for leafy brassicas and other new uses; metiram wine grapes only

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Lifetime risk Subgroup body wt/day (Q*= .0601)

-------------------------------------- ------------- ------------- U.S. Population (total) 0.000047 2.82E-06

U.S. Population (spring season) 0.000049 2.95E-06 U.S. Population (summer season) 0.000048 2.90E-06 U.S. Population (autumn season) 0.000045 2.70E-06 U.S. Population (winter season) 0.000046 2.75E-06

Northeast region 0.000051 3.06E-06 Midwest region 0.000040 2.40E-06 Southern region 0.000042 2.53E-06 Western region 0.000059 3.53E-06

Hispanics 0.000053 3.16E-06 Non-hispanic whites 0.000042 2.53E-06 Non-hispanic blacks 0.000052 3.14E-06 Non-hisp/non-white/non-black 0.000098 5.89E-06

All infants (< 1 year) 0.000051 3.10E-06 Nursing infants 0.000025 1.51E-06 Non-nursing infants 0.000062 3.70E-06 Children 1-6 yrs 0.000081 4.86E-06 Children 7-12 yrs 0.000043 2.60E-06

Females 13-19 (not preg or nursing) 0.000031 1.86E-06 Females 20+ (not preg or nursing) 0.000046 2.76E-06 Females 13-50 yrs 0.000045 2.69E-06 Females 13+ (preg/not nursing) 0.000108 6.49E-06 Females 13+ (nursing) 0.000031 1.88E-06

Males 13-19 yrs 0.000038 2.31E-06 Males 20+ yrs 0.000042 2.52E-06 Seniors 55+ 0.000048 2.86E-06

Children 1-2 yrs 0.000095 5.68E-06 Children 3-5 yrs 0.000078 4.67E-06 Children 6-12 yrs 0.000046 2.78E-06 Youth 13-19 yrs 0.000035 2.10E-06 Adults 20-49 yrs 0.000043 2.57E-06 Adults 50+ yrs 0.000048 2.87E-06 Females 13-49 yrs 0.000043 2.59E-06

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 67 of 71 -------------------------------------------------------------------------------

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 68 of 71 Attachment 12. Results File – ETU Aggregat e Cancer Food and Water – Critical Commodity Contribution Analysis

U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for ETU - AGGREGATE - CHRONIC (1994-98 data) Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Dietary2009\ETUAggregate2009\aggregateETUchronicpria2009foodandwater_10_18_10_new_leafy brassicas_metiram wine grapes onlyceleryincluded.R98 Adjustment factor #2 used. Analysis Date 10-18-2010/11:22:35 Residue file dated: 10-18-2010/09:45:13/8 Q* = 0.0601 COMMENT 1: celery included; Use 9/16/10 pct for leafy brassicas and other new uses; metiram wine grapes only

=============================================================================== Critical Commodity Contribution Analysis for U.S. Population (total)

Total Exposure =.000047 mg/kg bw/day

Crop groups with total exposure contribution > 5% Foods/Foodforms with exposure contribution > 1%

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Crop group -----------Exposure analysis---------- Food mg/kg | % of Total| Lifetime Risk Foodform body wt/day| Exposure |(Q*= .0601) -------------------------------------- -----------|-----------|--------------

Crop Group = (O) Other Banana (95000230): 110-Uncooked; Fresh or N/S; Cook Meth N/S
0.0000014 3.01% 8.50E-08 Cranberry, juice (95001320): 240-Cooked; Canned; Cook Meth N/S 0.0000005 1.14% 3.21E-08 Grape, wine and sherry (95001790): 110-Uncooked; Fresh or N/S; Cook Meth N/S
0.0000009 1.87% 5.29E-08 Mango (95002150): 110-Uncooked; Fresh or N/S; Cook Meth N/S
0.0000020 4.24% 1.20E-07 Papaya (95002450): 110-Uncooked; Fresh or N/S; Cook Meth N/S
0.0000005 1.15% 3.24E-08 Water, direct, all sources (86010000): FoodForm N/S 0.0000025 5.42% 1.53E-07 Water, indirect, all sources (86020000): FoodForm N/S 0.0000019 4.00% 1.13E-07 -------------------------------------- -----------|-----------|-------------- Total for crop group 0.0000120 25.55% 7.21E-07

Crop Group = (D) Dairy Products Milk, water (27022240): FoodForm N/S 0.0000014 3.05% 8.60E-08 -------------------------------------- -----------|-----------|-------------- Total for crop group 0.0000018 3.73% 1.05E-07

Crop group -----------Exposure analysis---------- Food mg/kg | % of Total| Lifetime Risk

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 69 of 71 Foodform body wt/day| Exposure |(Q*= .0601) -------------------------------------- -----------|-----------|--------------

Crop Group = (1) Root and Tuber Vegetables Potato, tuber, w/o peel (01033000): 212-Cooked; Fresh or N/S; Boiled 0.0000006 1.17% 3.31E-08 -------------------------------------- -----------|-----------|-------------- Total for crop group 0.0000018 3.85% 1.09E-07

Crop Group = (1C) Tuberous and Corm Vegetables Potato, tuber, w/o peel (01033000): 212-Cooked; Fresh or N/S; Boiled 0.0000006 1.17% 3.31E-08 -------------------------------------- -----------|-----------|-------------- Total for crop group 0.0000017 3.55% 1.00E-07

Crop Group = (4) Leafy Vegetables (except Brassica) Endive (04011500): 110-Uncooked; Fresh or N/S; Cook Meth N/S
0.0000012 2.58% 7.29E-08 Lettuce, head (04012040): 110-Uncooked; Fresh or N/S; Cook Meth N/S
0.0000014 3.02% 8.54E-08 Lettuce, leaf (04012050): FoodForm N/S 0.0000062 13.11% 3.70E-07 -------------------------------------- -----------|-----------|-------------- Total for crop group 0.0000093 19.77% 5.58E-07

Crop Group = (4A) Leafy Greens Endive (04011500): 110-Uncooked; Fresh or N/S; Cook Meth N/S
0.0000012 2.58% 7.29E-08 Lettuce, head (04012040): 110-Uncooked; Fresh or N/S; Cook Meth N/S
0.0000014 3.02% 8.54E-08 Lettuce, leaf (04012050): FoodForm N/S 0.0000062 13.11% 3.70E-07 -------------------------------------- -----------|-----------|-------------- Total for crop group 0.0000089 19.01% 5.37E-07

Crop group -----------Exposure analysis---------- Food mg/kg | % of Total| Lifetime Risk Foodform body wt/day| Exposure |(Q*= .0601) -------------------------------------- -----------|-----------|--------------

Crop Group = (5) Brassica (Cole) Leafy Vegetables Cabbage (05010690): 110-Uncooked; Fresh or N/S; Cook Meth N/S
0.0000008 1.81% 5.10E-08 212-Cooked; Fresh or N/S; Boiled 0.0000014 2.99% 8.44E-08 Collards (05021170): FoodForm N/S 0.0000011 2.39% 6.74E-08 Kale (05021940): FoodForm N/S 0.0000009 2.01% 5.68E-08 Turnip, greens (05023890): FoodForm N/S 0.0000015 3.14% 8.87E-08 -------------------------------------- -----------|-----------|-------------- Total for crop group 0.0000089 18.94% 5.35E-07

Crop Group = (5A) Brassica: Head and Stem Cabbage (05010690): 110-Uncooked; Fresh or N/S; Cook Meth N/S

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 70 of 71 0.0000008 1.81% 5.10E-08 212-Cooked; Fresh or N/S; Boiled 0.0000014 2.99% 8.44E-08 -------------------------------------- -----------|-----------|-------------- Total for crop group 0.0000043 9.06% 2.56E-07

Crop Group = (5B) Brassica: Leafy Greens Collards (05021170): FoodForm N/S 0.0000011 2.39% 6.74E-08 Kale (05021940): FoodForm N/S 0.0000009 2.01% 5.68E-08 Turnip, greens (05023890): FoodForm N/S 0.0000015 3.14% 8.87E-08 -------------------------------------- -----------|-----------|-------------- Total for crop group 0.0000046 9.88% 2.79E-07

Crop group -----------Exposure analysis---------- Food mg/kg | % of Total| Lifetime Risk Foodform body wt/day| Exposure |(Q*= .0601) -------------------------------------- -----------|-----------|--------------

Crop Group = (8) Fruiting Vegetables Pepper, bell (08002700): 110-Uncooked; Fresh or N/S; Cook Meth N/S
0.0000011 2.27% 6.41E-08 210-Cooked; Fresh or N/S; Cook Meth N/S
0.0000010 2.15% 6.08E-08 -------------------------------------- -----------|-----------|-------------- Total for crop group 0.0000054 11.59% 3.27E-07

Crop Group = (9) Curcurbit Vegetables Watermelon (09013990): FoodForm N/S 0.0000006 1.19% 3.37E-08 -------------------------------------- -----------|-----------|-------------- Total for crop group 0.0000016 3.38% 9.53E-08

Crop Group = (9A) Melons Watermelon (09013990): FoodForm N/S 0.0000006 1.19% 3.37E-08 -------------------------------------- -----------|-----------|-------------- Total for crop group 0.0000011 2.43% 6.87E-08

Crop Group = (11) Pome Fruits Apple, fruit with peel (11000070): 110-Uncooked; Fresh or N/S; Cook Meth N/S
0.0000012 2.64% 7.46E-08 Apple, juice (11000100): 110-Uncooked; Fresh or N/S; Cook Meth N/S
0.0000013 2.78% 7.84E-08 -------------------------------------- -----------|-----------|-------------- Total for crop group 0.0000035 7.44% 2.10E-07

Crop group -----------Exposure analysis---------- Food mg/kg | % of Total| Lifetime Risk Foodform body wt/day| Exposure |(Q*= .0601) -------------------------------------- -----------|-----------|--------------

Crop Group = (15) Cereal Grains Wheat, flour (15004020): 211-Cooked; Fresh or N/S; Baked 0.0000006 1.19% 3.35E-08 -------------------------------------- -----------|-----------|--------------

### Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 PC Code: 600016



## Page 71 of 71 Total for crop group 0.0000016 3.43% 9.69E-08

Total for crop groups listed above: 0.0000459 97.68% 2.76E-06

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