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| x   | Annual      Report pursuant to Section 13 or 15(d) of the Securities Exchange Act of      1934 for the fiscal year ended December 31, 2007  or |
|---------------|------------------------------------------------------------------------------------------------------------------------------------------------|

|   | * | Transition      Report pursuant to Section 13 or 15 (d) of the Securities Exchange Act of      1934 for the transition period from __________ to    __________ |
|--------|---|----------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   Delaware                                                               |            |                                            |       83-0221517    |
|------------------------------------------------------------------------------------|--------------------------------------------------------------|-------------------------------------------------|---------------------------------------------------|
|   (State      ofIncorporation)        |                      |                                            |    (I.R.S.      Employer I.D. No.) |
|                                                                               |                                                         |                                            |                                              |
|  2600 Stemmons      Freeway, Suite 176, Dallas,      TX                       |                                                         |        75207 |
|  (Address of      Principal Executive Offices)                      |                                                         |   (Zip      Code)                     |
|                                                                               |                                                         |                                            |                                              |
|                                                                               |                                                         |                                            |                                              |

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|   | Exhibit      Number |
|--------|---------------------|

| 2.1 | Amended      and Restated Agreement of Merger and Plan of Reorganization between Access      Pharmaceuticals, Inc. and Chemex Pharmaceuticals, Inc., dated as of      October 31, 1995 (Incorporated by reference to Exhibit A of the our      Registration Statement on Form S-4 dated December 21, 1995, Commission      File No. 33-64031) |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.2 | Agreement      and Plan of Merger, by and among Access Pharmaceuticals, Inc., Somanta      Acquisition Corporation, Somanta Pharmaceuticals, Inc. Somanta      Incorporated and Somanta Limited, dated April 18, 2007. (Incorporated by      reference to Exhibit 2.1 to our Form 8-K dated April 18,    2007) |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.0 | Articles      of incorporation and bylaws |
|-----|-------------------------------------------|

| 3.1 | Certificate      of Incorporation (Incorporated by Reference to Exhibit 3(a) of our Form      8-B dated July 12, 1989, Commission File Number  9-9134) |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.3 | Certificate      of Merger filed January 25, 1996. (Incorporated by reference to Exhibit E      of our Registration Statement on Form S-4 dated December 21, 1995,      Commission File No. 33-64031) |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.4 | Certificate      of Amendment of Certificate of Incorporation filed January 25, 1996.      (Incorporated by reference to Exhibit E of our Registration Statement on      Form S-4 dated December 21, 1995, Commission File No.      33-64031) |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.5 | Certificate      of Amendment of Certificate of Incorporation filed July 18, 1996.      (Incorporated by reference to Exhibit 3.8 of our Form 10-K for the year      ended December 31, 1996) |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.6 | Certificate      of Amendment of Certificate of Incorporation filed June 18, 1998.      (Incorporated by reference to Exhibit 3.8 of our Form 10-Q for the quarter      ended June 30, 1998 |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.7 | Certificate      of Amendment of Certificate of Incorporation filed July 31, 2000.      (Incorporated by reference to Exhibit 3.8 of our Form 10-Q for the quarter      ended March 31, 2001) |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.8 | Certificate      of Designations of Series A Junior Participating Preferred Stock filed      November 7, 2001 (Incorporated by reference to Exhibit 4.1.h of our      Registration Statement on Form S-8, dated December 14, 2001, Commission      File No. 333-75136) |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.9 | Amended      and Restated Bylaws (Incorporated by reference to Exhibit 3.1 of our Form      10-Q for the quarter ended June 30,1996) |
|-----|--------------------------------------------------------------------------------------------------------------------------------------|

| 3.10 | Certificate      of Designation of Series A Cumulative Convertible Preferred Stock filed      November 9, 2007 |
|------|----------------------------------------------------------------------------------------------------------------|

| 10.1* | 1995      Stock Option Plan (Incorporated by reference to Exhibit F of our      Registration Statement on Form S-4 dated December 21, 1995, Commission      File No. 33-64031 |
|-------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.2* | Amendment      to 1995 Stock Option Plan (Incorporated by reference to Exhibit 10.25 of      our Form 10-K for the year ended December 31,  2001) |
|-------|---------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.3 | Lease      Agreement between Pollock Realty Corporation and us dated July 25, 1996      (Incorporated by reference to Exhibit 10.19 of our Form 10-Q for the      quarter ended September 30, 1996) |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.4 | Platinate      HPMA Copolymer Royalty Agreement between The School of Pharmacy,      University of London and the Company dated November 19, 1996 (Incorporated      by reference to Exhibit 10.11 of our Form 10-K for the year ended December      31, 1996) |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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| 10.5* | Employment      Agreement of David P. Nowotnik, PhD (Incorporated by reference to Exhibit      10.19 of our Form 10-K for the year ended December 31,    1999) |
|-------|----------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.6* | 401(k)      Plan (Incorporated by reference to Exhibit 10.20 of our Form 10K for the      year ended December 31, 1999) |
|-------|-------------------------------------------------------------------------------------------------------------------------|

| 10.7 | Form      of Convertible Note (Incorporated by reference to Exhibit 10.24 of our      Form 10-Q for the quarter ended September 30,  2000) |
|------|--------------------------------------------------------------------------------------------------------------------------------------------|

| 10.8 | Rights      Agreement, dated as of October 31, 2001 between the us and American Stock      Transfer & Trust Company, as Rights Agent (incorporated by reference      to Exhibit 99.1 of our Current Report on Form 8-K dated October 19,      2001) |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.9 | Amendment      to Rights Agreement, dated as of February 16, 2006 between us and American      Stock Transfer & Trust Company, as Rights Agent  (2) |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.10 | Amendment      to Rights Agreement, dated as of November 9, 2007 between us and American      Stock Transfer & Trust Company as Rights  Agent |
|-------|---------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.11* | 2001      Restricted Stock Plan (Incorporated by reference to Appendix A of our      Proxy Statement filed on April 16,2001) |
|--------|------------------------------------------------------------------------------------------------------------------------------|

| 10.12* | 2005      Equity Incentive Plan (Incorporated by reference to Exhibit 1 of our Proxy      Statement filed on April 18, 2005(2) |
|--------|--------------------------------------------------------------------------------------------------------------------------------|

| 10.13* | Employment      Agreement, dated as of June 1, 2005 by and between us and Stephen B.      Thompson (1) |
|--------|--------------------------------------------------------------------------------------------------------|

| 10.15 | Amendment      to Asset Sale Agreement, dated as of December 8, 2006, between us and      Uluru, Inc. (3) |
|-------|-----------------------------------------------------------------------------------------------------------|

| 10.17 | Form      of Warrant, dated February 16, 2006, issued by us to certain Purchasers      (2) |
|-------|--------------------------------------------------------------------------------------------|

| 10.18 | Form      of Warrant, dated October 24, 2006, issued by us to certain Purchasers      (3) |
|-------|-------------------------------------------------------------------------------------------|

| 10.19 | Form      of Warrant, December 6, 2006, issued by us to certain Purchasers      (3) |
|-------|-------------------------------------------------------------------------------------|

| 10.20* | 2007      Special Stock Option Plan and Agreement, dated January 4, 2007, by and      between us and Stephen R. Seiler, President and Chief Executive Officer      (4) |
|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.21 | Note      Purchase Agreement dated April 26, 2007 between us and Somanta      Pharmaceuticals, Inc. (Incorporated by reference to Exhibit 10.42 of our      Form 10-Q for the quarter ended June 30,2007) |
|-------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.22 | Preferred      Stock and Warrant Purchase Agreement, dated November 7, 2007, between us      and certain Purchasers (5) |
|-------|-------------------------------------------------------------------------------------------------------------------------|

| 10.23 | Investor      Rights Agreement, dated November 10, 2007, between us and certain      Purchasers (5) |
|-------|-----------------------------------------------------------------------------------------------------|

| 10.24 | Form      of Warrant Agreement dated November 10, 2007, between us and certain      Purchasers (5) |
|-------|----------------------------------------------------------------------------------------------------|

| 10.25 | Board      Designation Agreement, dated November 15, 2007, between us and SCO Capital      Partners LLC (5) |
|-------|-------------------------------------------------------------------------------------------------------------|

| 10.26 | Amendment      and Restated Purchase Agreement, dated February 4, 2008 between us and      certain Purchasers (5) |
|-------|-------------------------------------------------------------------------------------------------------------------|

| 10.27 | Amended      and Restated Investor Rights Agreement, dated February 4, 2008 between us      and certain Purchasers (5) |
|-------|------------------------------------------------------------------------------------------------------------------------|

| 10.28* | Employment      Agreement, dated January 4, 2008 between us and Jeffrey B. Davis      (5) |
|--------|-------------------------------------------------------------------------------------------|

| 21 | Subsidiaries      of the registrant (6) |
|----|-----------------------------------------|

| 31.1 | Chief      Executive Officer Certification Pursuant to 18 U.S.C. Section 1350, as      Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of      2002 |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 31.2 | Chief      Financial Officer Certification Pursuant to 18 U.S.C. Section 1350, as      Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of      2002 |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 32 | Chief      Executive Officer Certification Chief Financial Officer Certification      Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of      the Sarbanes-Oxley Act of 2002 (6) |
|----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| * | [Management      contract or compensatory plan required to be filed as an Exhibit to this      Form pursuant to Item 15(c) of thereport.] |
|---|-------------------------------------------------------------------------------------------------------------------------------------------|

| (1)   | Incorporated      by reference to our Form 10-K for the year ended December 31,      2005. |
|-----------------|--------------------------------------------------------------------------------------------|

| (2)   | Incorporated      by reference to our Form 10-Q for the quarter ended March 31,      2006. |
|-----------------|--------------------------------------------------------------------------------------------|

| (3)   | Incorporated      by reference to our Form 10-K for the year ended December 31,      2006. |
|-----------------|--------------------------------------------------------------------------------------------|

| (4)   | Incorporated      by reference to our Form 10-Q for the quarter ended March 31,      2007. |
|-----------------|--------------------------------------------------------------------------------------------|

| (5)   | Incorporated      by reference to our Form S-1, 333-149633.                                     |
|-----------------|-------------------------------------------------------------------------------------------------|
| (6)   | Incorporated      by reference to our Form 10-K for the year ended December 31,      2007  |

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