OFFICE OF CHEMICAL SAFETY 

AND POLLUTION PREVENTION 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

BIOPESTICIDES REGISTRATION ACTION DOCUMENT

(E,Z)-2,13-Octadecadien-1-yl Acetate 

PC Code 117242 

(E,Z)-2,13-Octadecadien-1-ol 

PC Code 117244 

 

SEX PHEROMONES OF THE DOGWOOD BORER 

U.S. Environmental Protection Agency 

 Office of Pesticide Programs 

Biopesticides and Pollution Prevention Division 

July 20, 2011 

This document is for informational purposes only and is representative of the Agency’s justification in 

registering products containing this active ingredient. This is not a legal document. 
(E,Z)-2,13-Octadecadien-1-yl Acetate and (E,Z)-2,13-Octadecadien-1-ol Page 2 of 12 

Biopesticides Registration Action Document

TABLE OF CONTENTS

I. EXECUTIVE SUMMARY .................................................................................................. 4

II. ACTIVE INGREDIENT OVERVIEW .............................................................................. 6

III. REGULATORY BACKGROUND...................................................................................... 6

A. Classification ........................................................................................................................ 6

B. Food Clearance/Tolerances ................................................................................................. 6

IV. RISK ASSESSMENT ........................................................................................................... 7

A. Active Ingredient Characterization.................................................................................... 7

B. Human Health Assessment.................................................................................................. 7

1. Toxicology Assessment .................................................................................................................................. 7 

2. Dose Response Assessment ........................................................................................................................... 7 

3. Food Quality Protection Act (FQPA) Consideration ................................................................................. 8 

4. Occupational, Residential, School and Day Care Exposure and Risk Characterization ........................ 8 

5. Cumulative Effects ........................................................................................................................................ 8 

6. Risk Characterization ................................................................................................................................... 9

C. Environmental Assessment ................................................................................................. 9

1. Ecological Effects and Hazards Assessment ............................................................................................... 9 

2. Environmental Fate and Ground Water Data ............................................................................................ 9 

3. Ecological Exposure and Risk Characterization ........................................................................................ 9 

4. Endangered Species Assessment .................................................................................................................. 9

D. Product Performance Data (Efficacy) ................................................................................ 9

V. RISK MANAGEMENT DECISION ................................................................................. 10

A. Determination of Eligibility for Registration .................................................................. 10

B. Regulatory Decision ........................................................................................................... 10

C. Environmental Justice ....................................................................................................... 11

VI. ACTIONS REQUIRED BY REGISTRANTS.................................................................. 11

A. Reporting of Adverse Effects ............................................................................................ 11

B. Reporting of Hypersensitivity Incidents .......................................................................... 11

VII. APPENDIX A: References ................................................................................................. 12
(E,Z)-2,13-Octadecadien-1-yl Acetate and (E,Z)-2,13-Octadecadien-1-ol Page 3 of 12 

Biopesticides Registration Action Document

BIOPESTICIDES REGISTRATION ACTION DOCUMENT (BRAD) TEAM 

Office of Pesticide Programs: 

Biopesticides and Pollution Prevention Division 

Biochemical Pesticides Branch (BPB)

Gina Casciano Regulatory Action Leader

Linda Hollis Branch Chief 

Manying Xue Chemist 
(E,Z)-2,13-Octadecadien-1-yl Acetate and (E,Z)-2,13-Octadecadien-1-ol Page 4 of 12 

Biopesticides Registration Action Document

I. EXECUTIVE SUMMARY 

The new active ingredients (E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-

ol are technical grade synthetic Straight-Chain Lepidopteran Pheromones (SCLPs). These 

pheromones are structurally similar to, and mimic, naturally occurring pheromones produced by 

the female dogwood borer, Synanthedon scitula, to attract males for mating. These synthetic 

technical grade active ingredients (TGAIs), (E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-

2,13-octadecadien-1-ol, are intended to mitigate the effects of the dogwood borer by disrupting 

the normal mating cycle of this pest in pome fruit, stone fruit, and tree nut crops, and in 

ornamental nursery crops. The pesticide product formulated with these TGAIs will be dispensed 

in polymeric tubes. The product consists of two tubes fused together in a parallel fashion, one 

containing the end-use product formulation and the other containing a wire. The wire allows the 

entire dispenser to be twisted around the branches of a tree. The product will only be dispensed 

in this manner. The product will not be applied through any type of irritation system. The 

product will be applied in the spring before dogwood borer adult emergence. 

The dogwood borer, Synanthedon scitula, is a documented pest of at least 19 species of fruit, nut, 

and ornamental trees in the eastern United States and Canada (Zhang et al., 2005). The larvae 

feed on the inner bark of live, healthy trees. The damaged area of the trunk or branch swells and 

eventually the bark will fall off; infested branches and limbs will die. Dogwood borers often will 

not kill the tree in the first year, but reinfestation in successive years will generally kill the tree. 

The end-use product ISOMATE®-DWB, containing 5.46% and 0.27% of the active ingredients 

(E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol, respectively, is intended 

to disrupt the mating of the dogwood borer, therefore decreasing the number of larvae to feed on 

trees later that season.

SCLPs have been well characterized by the Agency since 1994 when the Agency issued a final 

rule establishing an exemption from the requirement of a tolerance for residues from the use of 

lepidopteran pheromones that are naturally occurring compounds, or identical or substantially 

similar synthetic compounds (40 CFR 180.1153). In addition, EPA’s regulations at 40 CFR 

158.2050(a)(2) and 158.2060(a)(2) exempt SCLP manufacturing-use products from human 

health and environmental toxicology data requirements. These data were waived based on the 

criteria presented in the OECD publication - Guidance for Registration Requirements for 

Pheromones and Other Semiochemicals Used for Pest Control (OCED, 2002; 

http://www.epa.gov/pesticides/biopesticides/regtools/index.htm). No risks to human health are 

expected from the use of lepidopteran pheromones based on demonstrated low toxicity in animal 

testing and expected low exposure to humans. Furthermore, adverse effects to non-target 

organisms are not expected because pheromones are released in very small quantities in the 

environment and act on a select group of insects. Thus, given that these compounds present both 

low hazard and low exposure, the Agency has determined that, when used as directed, they 

present low risk to both humans and non-target organisms. 

This Biopesticides Registration Action Document (BRAD) serves as an additional chapter to be 

added to the original SCLP BRAD issued by the Agency in 2001 

(http://www.epa.gov/opp00001/biopesticides/ingredients/tech_docs/brad_129109.pdf). This 

chapter is specific to (E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol, 

synthetic SCLPs of the female dogwood borer, Synanthedon scitula. Product chemistry data 

requirements for the end-use product (EP), ISOMATE®-DWB, were satisfied by acceptable 
(E,Z)-2,13-Octadecadien-1-yl Acetate and (E,Z)-2,13-Octadecadien-1-ol Page 5 of 12 

Biopesticides Registration Action Document

guideline studies. Data waiver rationale submitted to address human health and environmental 

toxicology data requirements for the end-use product is acceptable. 

On October 1, 2009, EPA announced a new policy to provide a more meaningful opportunity for 

the public to participate in major registration decisions before they occur. According to this new 

policy, EPA intends to provide a public comment period prior to making a registration decision 

for, at minimum, the following types of applications: new active ingredients, first food use, first 

outdoor use, first residential use, or actions for which EPA anticipates significant public interest. 

Consistent with the new policy of making registration actions more transparent, (E,Z)-2,13-

octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol are subject to a 30-day comment 

period as “new active ingredients,” the registration of which would result in a “first outdoor use, 

first food use, and first residential use.” The intent of the 30-day comment period is to provide a 

more meaningful opportunity for the public to participate in major registration decisions before 

they occur. The notice for this comment period includes the draft BRAD and the draft product 

label for ISOMATE®-DWB. The docket ID is EPA-HQ-OPP-2011-0247. While a final decision 

on registration is contingent upon review and consideration of public comments, at this time the 

Agency believes that based on the risk assessment and information submitted in support of the 

registration of (E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol, it is in the 

public interest to issue these registrations. The basis for this decision can be found in the risk 

assessment for (E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol, which is 

characterized in this BRAD. 
(E,Z)-2,13-Octadecadien-1-yl Acetate and (E,Z)-2,13-Octadecadien-1-ol Page 6 of 12 

Biopesticides Registration Action Document

II. ACTIVE INGREDIENT OVERVIEW 

Common Name: 

Chemical Name: 

Trade & Other Names: 

CAS Registry Number: 

OPP Chemical Code: 

Type of Pesticide: 

(E,Z)-2,13-octadecadien-1-

yl acetate 

 

(2E,13Z)-2,13-

octadecadien-1-yl acetate 

Dogwood Borer 

Pheromone 

86252-65-5 

117242 

Mating disruptant for 

dogwood borer 

(E,Z)-2,13-octadecadien-1-

ol 

(2E,13Z)-2,13-

octadecadien-1-ol 

Dogwood Borer 

Pheromone 

123551-47-3 

117244 

Mating disruptant for 

dogwood borer 

III. REGULATORY BACKGROUND 

On February 10, 2011, Pacific Biocontrol Corporation submitted an application for registration 

of end-use product (EP) Isomate-DWB, containing the active ingredients (E,Z)-2,13-

octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol, at 5.46% and 0.27%, respectively. 

A notice of receipt of the application for registration of (E,Z)-2,13-octadecadien-1-yl acetate and 

(E,Z)-2,13-octadecadien-1-ol as new active ingredients was published in the Federal Register on 

Wednesday, March 30, 2011 (76 FR 17644), with a 30-day comment period. No comments were 

received in response to this publication. 

A. Classification 

(E,Z)-2,13-Octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol are synthetic Straightchain Lepidopteran Pheromones and are classified as biochemical pesticides. 

B. Food Clearance/Tolerances 

 SCLPs are exempt from the requirement of a tolerance in or on all raw agricultural commodities 

when applied to growing crops at a rate not to exceed 150 grams of active ingredient/acre/year 

and in accordance with good agricultural use practices, and in indoor post-harvest treatment in or 

on all stored food commodities when applied/used at a rate not to exceed 3.5 grams active 

ingredient (AI)/1,000 square feet/year (equivalent of 150 grams AI/acre/year), in accordance 

with good agricultural use practices (40 CFR 180.1153). Pheromones are ubiquitous in the 

environment, and are not considered to be air pollutants. During the season when moths and/or 

butterflies appear, they normally emit pheromones and humans are naturally exposed to these 

pheromones without knowledge and without any adverse reactions. 
(E,Z)-2,13-Octadecadien-1-yl Acetate and (E,Z)-2,13-Octadecadien-1-ol Page 7 of 12 

Biopesticides Registration Action Document

IV. RISK ASSESSMENT 

A. Active Ingredient Characterization 

(E,Z)-2,13-Octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol are technical grade 

synthetic straight-chain lepidopteran pheromones. These pheromones are structurally similar to, 

and mimic, naturally occurring pheromones produced by the female dogwood borer, 

Synanthedon scitula, to attract males for mating. EPA reviewed the applicant’s data on the 

product formulation, production and packaging and determined that they all met current Agency 

standards. Acceptable results were provided regarding the preliminary analysis of five batches of 

the product. All required physical and chemical characteristics were adequately presented. 

B. Human Health Assessment 

1. Toxicology Assessment 

The end-use product ISOMATE®-DWB has a low application rate (not to exceed 150 grams 

active ingredient/acre/year) and expected exposure to humans is low. Adequate information and 

scientific rationales to address all toxicity requirements for this product were submitted by the 

applicant. SCLP’s are exempt from the requirement of a tolerance (40 CFR 180.1153); therefore, 

dietary exposure is not a concern. Additionally, there will be no purposeful exposure to human 

skin, and inhalation exposure is negligible. In summary, no risk to human health is expected 

from the use of ISOMATE®-DWB. 

2. Dose Response Assessment 

ISOMATE®-DWB consists of two parallel polymeric tubes fused together, one containing the 

end-use product formulation and the other containing a wire. The wire allows the entire 

dispenser to be twisted around the branch of a tree. ISOMATE®-DWB contains the active 

ingredients (E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol at 5.46% and 

0.27%, respectively. The product also contains two other synthetic dogwood borer pheromones 

that were previously registered with the Agency. The application use rate on the product label 

considers the total sum of all four of these pheromones and sets a total allowable application rate 

of 200 dispensers per acre, or 11.02 grams total pheromone, per application. Application must 

not exceed 150 grams of total pheromone/acre/year. Thus, if applying at maximum label rate 

during each application, the applicator would need to apply at a frequency greater than thirteen 

times per year in order to exceed the application limit. This worst-case scenario of 11.02 grams 

total pheromone applied thirteen times per year would equal an approximate daily application 

rate of 393 mg total pheromone/acre/day. 

Compared to typical natural exposure, codling moths during the calling period are estimated to 

release approximately 240 ng pheromone/hr (OECD, 2002), resulting in total pheromone release 

between 96 and 2,184 mg pheromone/acre/day. Thus, worst-case year-round application of 

ISOMATE®-DWB would be in the lower range of natural release by a living lepidopteran. And, 

given that the total level of dogwood borer pheromone emitted by ISOMATE®-DWB is 

comparable to naturally occurring emissions of pheromones during an infestation, the Agency 

concludes that it will have no impact on human health, non-target organisms, or the environment. 
(E,Z)-2,13-Octadecadien-1-yl Acetate and (E,Z)-2,13-Octadecadien-1-ol Page 8 of 12 

Biopesticides Registration Action Document

3. Food Quality Protection Act (FQPA) Consideration 

a. Dietary Exposure and Risk Characterization 

In accordance with 40 CFR 180.1153, SCLPs such as (E,Z)-2,13-octadecadien-1-yl acetate and 

(E,Z)-2,13-octadecadien-1-ol are exempt from the requirement of a tolerance. Moreover, as 

discussed in the human health assessment, the end-use product ISOMATE®-DWB poses 

negligible toxicological hazard, including dietary hazard. Therefore, given the negligible dietary 

hazard and the limited possibility of dietary exposure, we conclude that there will be very low 

risk associated with dietary exposure to ISOMATE®-DWB. We note that this is consistent with 

the conclusion of the OECD, which has determined that consumption of food containing residues 

of SCLPs presents no risk (OECD, 2002). 

b. Drinking Water Exposure and Risk Characterization 

No significant drinking water exposure or residues are expected to result from the pesticidal 

usage of (E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol. These active 

ingredients are contained inside a closed polymeric tube dispenser. The product will be applied 

to terrestrial areas only, and is not applied directly to water, to areas where surface water is 

present, or to intertidal areas below the mean water mark. Aerial applications are not allowed. If 

used in accordance with EPA-approved labeling, these active ingredients are not likely to 

accumulate in drinking water. As a result, dietary and drinking water exposure to residues of 

(E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol are expected to be 

minimal. 

4. Occupational, Residential, School, and Day Care Exposure and Risk 

Characterization 

 

(E,Z)-2,13-Octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol act via a non-toxic 

mode of action on a specific target pest. The end-use product containing these active ingredients 

is intended for agricultural use only (on food and ornamental crops). The expected exposure to 

humans and food/feed crops is low because the product is contained in a polymeric dispenser 

that is attached to tree limbs, and thus is not expected to come into direct contact with fruit or 

nuts. In addition, the potential for dermal, eye, and inhalation exposure to (E,Z)-2,13-

octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol for handlers is minimal due to the 

nature of the dispenser. The Agency also requires labels for products containing this active 

ingredient to include the appropriate signal word and precautionary statements. 

No outdoor or indoor residential, school, or day care uses are currently approved for products 

containing (E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol. 

5. Cumulative Effects 

Section 408(b)(2)(D)(v) of the Federal Food, Drug, and Cosmetic Act (FFDCA) requires the 

Agency to consider the cumulative effect of exposure to (E,Z)-2,13-octadecadien-1-yl acetate 

and (E,Z)-2,13-octadecadien-1-ol and other substances that have a common mechanism of 

toxicity. These considerations include the possible cumulative effects of such residues on infants 

and children. (E,Z)-2,13-Octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol have a 

non-toxic mode of action and there is no indication or evidence to suggest that these biochemical 
(E,Z)-2,13-Octadecadien-1-yl Acetate and (E,Z)-2,13-Octadecadien-1-ol Page 9 of 12 

Biopesticides Registration Action Document

pesticides share a common mechanism of toxicity with any other substance. Therefore, 

cumulative exposure concerns are not anticipated for the product ISOMATE®-DWB. 

6. Risk Characterization 

(E,Z)-2,13-Octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol are synthetic 

semiochemicals that act via a non-toxic mode of action on a specific insect pest. Given the low 

toxicity of lepidopteran pheromones in animal testing, and the expected low exposure to humans, 

no risk to human health is expected from use of the product ISOMATE®-DWB. The Agency has 

considered the various routes of exposure and potential risks of the product and determined that 

the proposed use of the active ingredient does not pose significant risk to all populations, 

including infants and children. 

C. Environmental Assessment 

1. Ecological Effects and Hazards Assessment 

According to 40 CFR 158.2060 (a)(2), SCLPs applied up to a maximum use rate of 150 grams 

active ingredient/acre/year, and that are not expected to be available to avian species, are not 

required to address non-target toxicity data requirements. (E,Z)-2,13-Octadecadien-1-yl acetate 

and (E,Z)-2,13-octadecadien-1-ol are synthetic pheromones subject to 40 CFR 158.2060(a)(2), 

which acts on a select group of insects and has a non-toxic mode of action. 

2. Environmental Fate and Ground Water Data 

Environmental fate data are not required for this active ingredient because it is an SCLP being 

applied at a maximum use rate of 150 grams active ingredient/acre/year and is not expected to be 

available to avian species (40 CFR 158.2060). 

3. Ecological Exposure and Risk Characterization 

According to 40 CFR 158.2060 (a)(2), ecological and environmental fate data are not required 

because the active ingredient is an SCLP being applied at a maximum use rate of 150 grams 

active ingredient/acre/year and is not expected to be available to avian species. (E,Z)-2,13-

Octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol are synthetic pheromone subject to 

40 CFR 158.2060(a)(2), which acts on a select group of insects and has a non-toxic mode of 

action. 

4. Endangered Species Assessment 

Granted that (E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol are not toxic 

to non-target organisms, the Agency has determined that they will have "No Effect" on any 

currently listed threatened or endangered species, or on any designated critical habitat. 

D. Product Performance Data (Efficacy) 

Product performance data must be developed for all pesticides to ensure that pesticide products 

will perform as intended and that unnecessary pesticide exposure to the environment will not 

occur as a result of the use of ineffective products. The Agency reserves the right to require on a 
(E,Z)-2,13-Octadecadien-1-yl Acetate and (E,Z)-2,13-Octadecadien-1-ol Page 10 of 12 

Biopesticides Registration Action Document

case-by-case basis, submission of efficacy data for any pesticide product registered or proposed 

for registration that are intended to be used to control a pest of significance public health 

importance and a public health pest defined in FIFRA section 28(d) and section 2(nn). For 

further guidance on product performance requirement, refer to Pesticide Registration Notice (PR) 

Notices 96-7, 2002-1 and Explanation of Statutory Framework for Risk-Benefit Balancing for 

Public Health Pesticides. For further guidance, please refer to Pesticide Registration Notice 96-7 

(http://www.epa.gov/PR _Notices/pr1996-7.pdf), (http://www.ea.gov/PR_Notices/pr2002-1.pdf) 

and (http://www.epa.gov/pesticides/health/risk-benefit.htm). 

V. RISK MANAGEMENT DECISION 

A. Determination of Eligibility for Registration 

Section 3(c)(5) of FIFRA provides for the registration of a new active ingredient if it is 

determined that (A) its composition is such as to warrant the proposed claims for it; (B) its 

labeling and other materials required to be submitted comply with the requirements of FIFRA; 

(C) it will perform its intended function without unreasonable adverse effects on the 

environment; and (D) when used in accordance with widespread and commonly recognized 

practice it will not generally cause unreasonable adverse effects on the environment. 

These four criteria of the eligibility determination for pesticidal active ingredients are satisfied 

by the science assessments evaluating the subject registration application for products containing 

(E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol. Such products are not 

expected to cause unreasonable adverse effects on the environment, and are likely to provide 

protection as claimed when used according to label instructions. Therefore, (E,Z)-2,13-

octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol are eligible for registration for the 

labeled uses. 

B. Regulatory Decision 

At this time, EPA believes that the data submitted fulfill the requirements of registration for 

products containing (E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol for 

use as mating disrupters of the dogwood borer at a rate not to exceed 3.5 grams active ingredient 

(AI)/1,000 square feet/year (equivalent of 150 grams AI/acre/year). EPA has determined that 

(E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol present no issues of 

toxicological, ecological, or environmental concern, will not cause harm to humans and will not 

cause unreasonable adverse effects on the environment. EPA has no concerns for any non-target 

organisms exposed to (E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol in 

accordance with their approved uses. EPA has not identified any meaningful toxic endpoints for 

non-target mammals, birds, plants, aquatic, or soil organisms; nor are there concerns for any 

threatened and endangered species. Given the non-toxic nature of (E,Z)-2,13-octadecadien-1-yl 

acetate and (E,Z)-2,13-octadecadien-1-ol, EPA intends to issue registrations for these 

biochemical pesticides under Section 3(c)(5) of the Federal Insecticide, Fungicide, and 

Rodenticide Act (FIFRA). 

Acute toxicity data for SCLPs, as discussed above, indicate that they be characterized as toxicity 

category III or IV. The end-use product will be characterized as toxicity category III. 

ISOMATE®-DWB does not demonstrate subchronic or developmental toxicity, and it is not 

mutagenic or genotoxic. EPA has no concerns for any non-target organisms exposed to 
(E,Z)-2,13-Octadecadien-1-yl Acetate and (E,Z)-2,13-Octadecadien-1-ol Page 11 of 12 

Biopesticides Registration Action Document

ISOMATE®-DWB in accordance with approved label directions. EPA has not identified any 

toxic endpoints for non-target mammals, birds, plants, aquatic, or soil organisms. There are no 

concerns for any threatened or endangered species. Thus, given that ISOMATE®-DWB has very 

low toxicity and presents little, if any, risk to non-target organisms, EPA concludes that it is in 

the public interest to issue the registration for ISOMATE®-DWB. 

C. Environmental Justice 

EPA seeks to achieve environmental justice, the fair treatment and meaningful involvement of all 

people, regardless of race, color, national origin, or income, in the development, implementation, 

and enforcement of environmental laws, regulations, and policies. To help address potential 

environmental justice issues, the Agency seeks information on any groups or segments of the 

population who, as a result of their location, cultural practices, or other factors, may have 

atypical or unusually high exposure to (E,Z)-2,13-octadecadien-1-yl acetate and (E,Z)-2,13-

octadecadien-1-ol, compared to the general population. Please comment if you are aware of any 

sub-populations that may have atypical or unusually high exposure as compared to the general 

population. 

VI. ACTIONS REQUIRED BY REGISTRANTS 

The Agency has evaluated all data submitted in connection with the initial registration of (E,Z)-

2,13-octadecadien-1-yl acetate and (E,Z)-2,13-octadecadien-1-ol and determined that these data 

are sufficient to satisfy current registration data requirements. No additional data are required to 

be submitted to the Agency at this time. For new uses and/or changes to existing uses, additional 

data may be required. 

Notwithstanding the information stated in the previous paragraph, it should be clearly understood 

that certain, specific, data are required to be reported to the Agency as a requirement for 

maintaining the Federal registration for a pesticide product. A brief summary of these types of 

data are listed below. 

A. Reporting of Adverse Effects 

Reports of all incidents of adverse effects to the environment must be submitted to the Agency 

under the provisions stated in FIFRA, Section 6(a)(2). 

B. Reporting of Hypersensitivity Incidents 

Additionally, all incidents of hypersensitivity (including both suspected and confirmed incidents) 

must be reported to the Agency under the provisions of 40 CFR Part 158.2050(d). 

 
(E,Z)-2,13-Octadecadien-1-yl Acetate and (E,Z)-2,13-Octadecadien-1-ol Page 12 of 12 

Biopesticides Registration Action Document

VII. APPENDIX A: References 

OECD (2002) Series on Pesticides No. 12: Guidance for Registration Requirements for 

Pheromones and Other Semiochemicals Used for Arthropod Pest Control. Organization for 

Economic Cooperation and Development (OECD). Issued: 02/26/2002. Available at: 

http://www.epa.gov/pesticides/biopesticides/regtools/index.htm 

Zhang, A., Leskey, T.C., Bergh, J.C., and J.F. Walgenbach. (2005) Sex Pheromone of the 

Dogwood Borer, Synanthedon scitula. Journal of Chemical Ecology, 31(10): 2463-2479.