EXHIBIT 10.4

SECURITIES PURCHASE AGREEMENT

TO PURCHASE

CONVERTIBLE NOTES

AND

COMMON STOCK PURCHASE WARRANTS





SYNTHETIC BLOOD INTERNATIONAL,
INC.





The securities have not been registered under the Securities Act of 1933 and may not be offered or sold in the United States or to U.S. persons (other
than distributors) unless the securities are registered under the Securities Act of 1933, or an exemption from the registration requirements of the Securities Act of 1933 is available.

The Securities and any other rights pursuant to this Agreement cannot be sold, transferred, assigned, or otherwise disposed of for value, except in
compliance with applicable federal and state securities laws.

The Securities have not been approved or disapproved by the
Commission or any state or other regulatory authority, nor has the Commission or any state or other regulatory authority passed on the accuracy or adequacy of any offering information provided. Any representation to the contrary is a criminal
offense.





Subject to the terms and conditions set forth herein, this SECURITIES PURCHASE AGREEMENT (this Agreement), dated as of January
__, 2008, by and between SYNTHETIC BLOOD INTERNATIONAL, INC., a New Jersey corporation (the Company), and the undersigned investor (the Investor), shall constitute the irrevocable offer of the
undersigned to purchase securities of the Company.

The Investor presently holds certain promissory notes issued by the Company in the
aggregate amount indicated on the signature page hereto, including any principal and accrued but unpaid interest (the Existing Indebtedness). On the terms and subject to the conditions set forth in this Agreement, the Company wishes to
sell to the Investor, in exchange for the cancellation of the Existing Indebtedness, (A) one or more Convertible Notes in the form attached hereto as Exhibit A(the Note or Notes) and
(B) one or more Warrants in the form attached hereto as Exhibit B (each, a Warrant and, collectively, the Warrants). The shares of Common Stock into which the Notes are convertible are
referred to herein as the Conversion Shares and the shares of Common Stock into which the Warrants are exercisable are referred to herein as the Warrant Shares. The Notes, the Conversion Shares,
the Warrants and the Warrant Shares are collectively referred to herein as the Securities.

The Notes are being
issued at a 55% original issue discount, meaning that the principal face amount of the Notes issued to Investor will be discounted by 55% to equal the amount of the Existing Indebtedness being canceled. The Notes will be convertible into Common
Stock to receive the number of shares equal to the Principal Amount divided by the Conversion Price (initially $0.247 per share of Common Stock). The Principal Amount and the Purchase Price are set forth on the signature page of this Agreement.



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The Warrants issued to Investor will be exercisable at any time for a period of five years from issuance,
subject to the terms and conditions set forth in the Warrants. The Warrants entitle the Investor to purchase a number of Warrant Shares equal to one-half the number of shares issuable upon conversion of the Notes purchased (without regard to any
restrictions on such conversion), at an exercise price initially equal to the Conversion Price, or $0.247 per each Warrant Share (the Warrant Exercise Price).

In consideration of the mutual promises made herein, and other good and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, the Company and the Investor hereby agree as follows:

1. PURCHASE AND SALE OF NOTES AND WARRANTS.

1.1 Subscription and Closing. Upon the terms and subject to the satisfaction or waiver of the conditions set forth herein, the Company agrees to
sell and the Investor agrees to purchase



| | (i) | a Note with a principal amount equal to the Principal Amount set forth on the signature page to this Agreement, such Note being convertible into shares of Common Stock at the
Conversion Price, and
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| | (ii) | a Warrant entitling the Investor to purchase shares of Common Stock at the Warrant Exercise Price, exercisable to purchase one-half the number of shares of Common Stock that the
Note is convertible into at the Conversion Price.
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The date on which the closing of such purchase and sale occurs (the
Closing) is hereinafter referred to as the Closing Date. The Closing will be deemed to occur when (A) this Agreement and the other Transaction Documents (as defined below) have been executed
and delivered by the Company and the Investor, (B) each of the conditions to the Closing described herein has been satisfied or waived as specified therein and (C) full payment of the Investors Purchase Price (as defined below)
payable with respect to the Note and Warrant has been made to the Company by the Investor tendering to the Company the original instruments evidencing the Existing Indebtedness and canceling the Existing Indebtedness in an amount equal to the
Purchase Price, which includes all principal and accrued but unpaid interest attributable to the Existing Indebtedness.

1.2 Certain
Definitions. When used herein, the following terms shall have the respective meanings indicated:

Affiliate means, as to any Person (the subject Person), any other Person (a) that directly or indirectly through one or more intermediaries controls or is controlled by, or is under
direct or indirect common control with, the subject Person, (b) that directly or indirectly beneficially owns or holds ten percent (10%) or more of any class of voting equity of the subject Person, or (c) ten percent (10%) or
more of the voting equity of which is directly or indirectly beneficially owned or held by the subject



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Person. For the purposes of this definition, control when used with respect to any Person means the power to direct the management
and policies of such Person, directly or indirectly, whether through the ownership of voting securities, through representation on such Persons board of directors or other management committee or group, by contract or otherwise.

Business Day means any day other than a Saturday, a Sunday or a day on which the New York Stock Exchange is
closed or on which banks in the State of California are required or authorized by law to be closed.

Closing is defined in Section 1.1.

Closing Date is
defined in Section 1.1.

Commission means the United States Securities and Exchange
Commission.

Common Stock means the common stock, par value $0.01 per share, of the Company.

Conversion Price has the meaning specified in the Notes and shall initially be $0.247 per share
of Common Stock.

Execution Date means the date of this Agreement.

Exchange Act means the Securities Exchange Act of 1934, as amended (or any successor act), and the rules and
regulations thereunder (or respective successors thereto).

Governmental Authority means any
nation or government, any state, provincial or political subdivision thereof and any entity exercising executive, legislative, judicial, regulatory or administrative functions of or pertaining to government, including without limitation any stock
exchange, securities market or self-regulatory organization.

Governmental Requirement means any
law, statute, code, ordinance, order, rule, regulation, judgment, decree, injunction, franchise, license or other directive or requirement of any federal, state, county, municipal, parish, provincial or other Governmental Authority or any
department, commission, board, court, agency or any other instrumentality of any of them.

FINRA
means the Financial Industry Regulatory Authority.

Original Issue Discount Percentage shall mean
55%, representing the sum of 11% per annum multiplied by five years.



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Person means any individual, corporation, trust, association,
company, partnership, joint venture, limited liability company, joint stock company, Governmental Authority or other entity.

Principal Amount means the principal face amount of the Notes to be issued to Investor, which amount will be equal to the Purchase Price divided by the difference between 100% and the Original Issue Discount
Percentage (55%), or 45%. By way of example, if the Purchase Price is $100, then the Principal Amount is equal to $100 divided by 0.45 ($222.22).

Purchase Price means, with respect to a Note and Warrant purchased at a Closing, the aggregate principal and accrued interest of the Existing Indebtedness.

Rule 144 means Rule 144 under the Securities Act or any successor provision.

Securities has the meaning specified in the preamble to this Agreement.

Transaction Documents means, collectively, this Agreement, the Notes and Warrants, and all other agreements,
documents and other instruments executed and delivered by or on behalf of the Company or the Investor at the Closing.

1.3 Other
Definitional Provisions. All definitions contained in this Agreement are equally applicable to the singular and plural forms of the terms defined. The words hereof, herein and hereunder and words of similar
import referring to this Agreement refer to this Agreement as a whole and not to any particular provision of this Agreement.

2. REPRESENTATIONS AND
WARRANTIES OF THE INVESTOR.

The Investor hereby represents and warrants to the Company that, as of the Execution Date:

2.1 Authorization; Enforceability. This Agreement constitutes, and upon execution and delivery thereof, each other Transaction Document to
which the Investor is a party will constitute, the Investors valid and legally binding obligation, enforceable in accordance with its terms, subject to (i) applicable bankruptcy, insolvency, fraudulent transfer, reorganization, moratorium
or other similar laws of general application relating to or affecting the enforcement of creditors rights generally and (ii) general principles of equity. The Investor further understands and acknowledges that this Agreement is and shall
be irrevocable except that the Investor shall have no obligations hereunder in the event that this Agreement is for any reason rejected by the Company.

2.2 Investor Status. The Investor represents and warrants as follows:

(a) Investor is not a U.S.
Person and Investor was not formed for the purpose of investing in the Securities, which have not been registered under the 1933 Act in reliance upon Regulation S, by or for the benefit of a U.S. person.



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(b) At the time the buy order was originated, Investor was outside the United States.

(c) No offer to sell or purchase the Securities was made in the United States.

(d) Investor has not engaged in nor will engage in any Directed Selling Efforts, i.e., any activity undertaken for the purpose of, or that
could reasonably be expected to have the effect of, conditioning the market in the United States for any of the Securities being purchased by the Investor.

(e) Investor is purchasing the Securities for its own account and for investment purposes and not with the view towards distribution or for the account of a U.S. Person.

(f) All subsequent offers and sales of the Securities shall be made in compliance with Regulation S and/or pursuant to registration of the Securities
under the 1933 Act or pursuant to an exemption from registration under the 1933 Act. Unless registered for sale under the 1933 Act, the Securities will not be resold to U.S. Persons or within the United States until after the end of a one year
restricted period (or such shorter period as may be hereafter stated in Regulation S) commencing on the date of closing of the purchase of the Securities and otherwise in compliance with Rule 904 of Regulation S.

(g) The Securities are being offered and sold to Investor in reliance on Regulation S and the Company is relying upon the truth and accuracy of
Investors representations and warranties in order to justify such reliance in connection with the sale of the Securities to Investor.

(h) Investor has received and reviewed the Companys annual report on Form 10-K for the fiscal year ended April 30, 2006, quarterly reports on Form 10-Q for the interim periods ended July 31, 2006, and October 2006, and
current reports on Form 8-K dated October 10, 2006 and August 30, 2006 as filed with the Securities and Exchange Commission, and has had an opportunity to ask questions of and receive information from the Company and its executive officers
and has availed itself of such opportunity to the fullest extent desired by Investor.

2. 3 Investment Considerations. The Investor
is acquiring the Securities solely for Investors own account and not with a present view to the public resale or distribution of all or any part thereof, except pursuant to sales that are registered under, or exempt from the registration
requirements of, the Securities Act and/or sales registered under the Securities Act. The Investor can bear the economic risk of a total loss of its investment in the Securities and has such knowledge and experience in business and financial matters
so as to enable it to understand the risks of and form an investment decision with respect to its investment in the Securities.



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2.4 Information. The Company has, prior to the Execution Date, provided the Investor with
information regarding the business, operations and financial condition of the Company (including the Companys annual report on Form 10-K for the year ended April 30, 2007, as filed with the Commission, and each report filed by the Company
with the Commission since said annual report was filed) and has, prior to the Execution Date, granted to the Investor the opportunity to ask questions of and receive answers from representatives of the Company, its officers, directors, employees and
agents concerning the Company and materials relating to the terms and conditions of the purchase and sale of the Notes and Warrants hereunder, in order for the Investor to make an informed decision with respect to its investment in the Notes and
Warrants. Neither such information nor any other investigation conducted by the Investor or any of its representatives shall modify, amend or otherwise affect the Investors right to rely on the Companys representations and warranties
contained in this Agreement.

2.5 Limitations on Disposition. The Investor acknowledges that none of the Securities have been and
are not being registered under the Securities Act and may not be transferred or resold without registration under the Securities Act or unless pursuant to an exemption therefrom. The Investor agrees that neither it nor any Person acting on its
behalf or at its direction will engage in any transactions in securities of the Company prior to the time that the transactions contemplated by this Agreement are publicly disclosed.

2.6 Legend. The Investor is aware that any transfer of the Securities is restricted by federal and state securities laws. The Investor understands
that the certificates representing any of the Securities may bear at issuance a restrictive legend in substantially the following form:

The securities represented by this certificate have not been registered under the Securities Act of 1933, as amended (the Securities Act), or the securities laws of any state, and may not be offered or sold unless a
registration statement under the Securities Act and applicable state securities laws shall have become effective with regard thereto, or an exemption from registration under the Securities Act and applicable state securities laws is available in
connection with such offer or sale.

Notwithstanding the foregoing, it is agreed that, as long as (A) the resale or transfer (including without
limitation a pledge) of any of the Securities is registered pursuant to an effective registration statement, (B) such Securities have been sold pursuant to Rule 144, subject to receipt by the Company of customary documentation reasonably
acceptable to the Company in connection therewith, or (C) such Securities are eligible for resale under Rule 144(k) or any successor provision, such Securities shall be issued without any legend or other restrictive language and, with respect
to Securities upon which such legend is stamped, the Company shall issue new certificates without such legend to the holder upon request.

2.7 Reliance on Exemptions. The Investor understands that the Securities are being offered and sold to it in reliance upon specific exemptions from the registration requirements of United States federal and state securities laws and
that the Company is relying upon the truth and accuracy of the representations and warranties of the Investor set forth in this Section 2 in order to determine the availability of such exemptions and the eligibility of the Investor to
acquire the Securities.



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2.8 Non-Affiliate Status; Common Stock Ownership. The Investor is not an Affiliate of the Company.
The Investors investment in Notes and Warrants is not for the purpose of acquiring, directly or indirectly, control of, and it has no intent to acquire or exercise control of, the Company or to influence the decisions or policies of the Board
of Directors.

2.9 Fees. The Investor is not obligated to pay any compensation or other fee, cost or related expenditure to any
underwriter, broker, agent or other representative in connection with the transactions contemplated hereby.

2.10 No Governmental
Review. The Investor understands that no United States federal or state agency or any other Governmental Authority has passed on or made any recommendation or endorsement of the Securities or the fairness or suitability of the investment in the
Securities nor have such authorities passed upon or endorsed the merits of the offering of the Securities.

3. REPRESENTATIONS AND WARRANTIES OF THE
COMPANY. The Company hereby represents and warrants to the Investor, and agrees with the Investor that, as of the Execution Date:

3.1 Organization, Good Standing and Qualification. The Company is duly organized, validly existing and in good standing under the laws of the jurisdiction of its incorporation or organization and has all requisite power and authority
to carry on its business as now conducted.

3.2 Authorization; Consents. The Company has the requisite corporate power and authority
to enter into and perform its obligations under this Agreement. The Company has the requisite corporate power and authority to issue and sell the Notes and the Warrants to the Investor in accordance with the terms hereof and thereof, to issue the
Conversion Shares upon conversion of the Notes and to issue the Warrant Shares upon exercise of the Warrants; provided, however, that the Company does not have a sufficient number of authorized shares of Common Stock to effect all such conversions
and exercises so the Company must amend its articles of incorporation to increase the number of authorized shares of Common Stock by such amount as is necessary to reserve for issuance the maximum aggregate number of Conversion Shares and Warrant
Shares then issued or potentially issuable in the future upon the exercise of the conversion rights under the Notes and exercise rights under the Warrants. All corporate action on the part of the Company by its officers, directors and stockholders
necessary for the authorization, execution and delivery of, and the performance by the Company of its obligations under, the Transaction Documents has been taken, and no further consent or authorization of the Company, its Board of Directors,
stockholders, any Governmental Authority or organization (other than amendment of the Companys Articles of Incorporation to increase the number of authorized shares of Common Stock as noted above), or any other person or entity is required
(pursuant to any rule of FINRA or otherwise).

3.3 Enforcement. On execution and delivery by the Company, this Agreement has been
and, at or prior to Closing, each other Transaction Document to be delivered at Closing will be, duly executed and delivered by the Company. On execution and delivery by the Company, each Transaction Document constitutes the valid and legally
binding obligation of the Company, enforceable against it in accordance with its terms, subject to (i) applicable bankruptcy, insolvency, fraudulent transfer, moratorium, reorganization or other similar laws of general application relating to
or affecting the enforcement of creditors rights generally, (ii) general principles of equity, and (iii) amendment of the Companys Articles of Incorporation to increase the number of authorized shares of Common



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Stock by such amount as is necessary to reserve for issuance the maximum aggregate number of Conversion Shares and Warrant Shares then issued or potentially
issuable in the future upon the exercise of the conversion rights under the Notes and exercise rights under the Warrants.

3.4 No
Conflict. The (i) execution, delivery and performance of this Agreement and the other Transaction Documents and (ii) consummation of the transactions contemplated hereby and thereby (including without limitation, the issuance of the
Notes and the Warrants and the reservation for issuance and issuance of the Conversion Shares and the Warrant Shares) will not result in any violation of any provisions of the Companys Articles of Incorporation, Bylaws or any other governing
document or in a default under any provision of any instrument or contract to which it is a party, or in violation of any provision of any Governmental Requirement that, in either such case, has not had or would not reasonably be expected to have a
material adverse effect.

3.5 Fees. The Company is not obligated to pay any brokers, finders or financial advisory fees or
commissions to any underwriter, broker, agent or other representative in connection with the transactions contemplated hereby. The Company will indemnify and hold harmless the Investor from and against any claim by any person or entity alleging that
the Investor is obligated to pay any such compensation, fee, cost or related expenditure in connection with the transactions contemplated hereby.

4.
COVENANTS OF THE COMPANY AND THE INVESTOR.

4.1 Limitations on Disposition. The Investor shall not sell, transfer,
assign or dispose of any Securities, unless:

(a) there is then in effect an effective registration statement under the
Securities Act covering such proposed disposition and such disposition is made in accordance with such registration statement; or

(b) the Investor has notified the Company in writing of any such disposition, has received the Companys written consent (which consent will not be unreasonably withheld) to such disposition and furnished the Company with an opinion of
counsel, reasonably satisfactory to the Company, that such disposition will not require registration of such Securities under the Securities Act; provided, however, that no such consent or opinion of counsel will be required (A) if the
sale, transfer or assignment is made to an Affiliate of the Investor, (B) if the sale, transfer or assignment is made pursuant to Rule 144 and the Investor provides the Company with evidence reasonably satisfactory to the Company that the
proposed transaction satisfies the requirements of Rule 144 or (C) in connection with a bona fide pledge or hypothecation of any Securities under a margin arrangement with a broker-dealer or other financial institution or the sale of any
such Securities by such broker-dealer or other financial institution following the Investors default under such margin arrangement.



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4.2 Indemnification of Company. Investor agrees to indemnify and hold Company harmless from any
loss, damage, liability or expense, including reasonable attorneys fees and other legal expenses, to which Company may become subject arising out of or relating to any act or omission of Investor or any person connected, affiliated or
associated with Investor which is or is alleged to be a violation of the Securities Act, the Exchange Act or rules promulgated under the securities statutes (including Regulation D) or any other domestic or foreign statutes, laws or regulations or
arising from Investors or such persons alleged negligence or willful misconduct. Investor will indemnify and hold Company harmless from any loss, which Company may sustain as a result of errors made by Investor.

4.3 Amendment of Articles of Incorporation. Prior to September 30, 2008, the Company shall take all action required by law to submit to the
shareholders of the Company a proposal to amend the Companys Articles of Incorporation to increase the number of authorized shares of Common Stock by such amount as is necessary to reserve for issuance the maximum aggregate number of
Conversion Shares and Warrant Shares then issued or potentially issuable in the future upon the exercise of the conversion rights under the Notes and exercise rights under the Warrants.

4.4 Registration. The Company shall file a registration statement with the Commission under the Securities Act for the purpose of registering on
or before January 9, 2009, resale of the Conversion Shares and Warrant Shares, and shall use its best efforts to keep such Registration Statement continuously effective under the Securities Act until the Conversion Shares and Warrant Shares
covered by such registration statement have been sold or may be sold without restriction pursuant to Rule 144 as determined by the counsel to the Company pursuant to a written opinion letter to such effect. The Company shall not be obligated to file
a registration statement with respect to any Conversion Shares or Warrant Shares that have been sold or may be sold without restriction pursuant to Rule 144 as determined by the counsel to the Company pursuant to a written opinion letter to such
effect. If: (i) a registration statement is not effective with respect to any Conversion Shares or Warrant Shares the Company is obligated to register for resale on or before the date specified above; or (ii) after the effective date a
registration statement ceases for any reason to remain continuously effective for all Conversion Shares and Warrant Shares for which it is required to be effective, or the Holders are not permitted to utilize the prospectus therein to resell such
shares for 20 consecutive trading days, but no more than an aggregate of 40 trading days during any 12-month period (which need not be consecutive trading days) (any such failure or breach being referred to as an Event, and for
purposes of clause (i) the date on which such Event occurs, or for purposes of clause (ii) the date on which such 20 or 40 trading day period, as applicable, is exceeded being referred to as Event Date), then within 10
days following each such Event Date and within 10 days following each monthly anniversary of each such Event Date (if the applicable Event shall not have been cured by such monthly anniversary date) until the applicable Event is cured, the Company
shall pay to each Holder an amount in cash, as liquidated damages and not as a penalty, equal to 1.0% of the aggregate market value on the Event Date of the Conversion Shares or Warrant Shares that are not so registered or cannot be sold under an
effective registration statement. The holder of the Securities shall provide to the Company in writing all information reasonably required by the Company to comply with its disclosure obligations in the registration statement imposed by the
Securities Act and the regulations promulgated thereunder. The failure of the holder of any of the Securities for any reason to provide such information at least five Business Days prior to the filing of the registration statement covering the
Conversion Shares or Warrant Shares shall effect a termination of any obligation of the Company to file any registration statement pertaining to the Securities and the Company shall have no liability to such holder with respect to the liquidated
damages stated above.



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4.5 Issuance of Securities. The Company will deliver or cause to be delivered to the Investor upon
receipt of this Agreement and the subscription payment certificates and instruments representing the Securities in the name of Investor. All certificates and instruments shall bear appropriate restrictive legends to the effect that no transfer of
the Securities may be made except in compliance with the provisions of Regulation S. The Company and Investor agree that the Companys transfer agent is hereby directed and authorized to refuse to register any transfer of the Securities that is
not made in accordance with the provisions of Regulation S.

5. MISCELLANEOUS.

5.1 Survival; Severability. The representations, warranties, covenants and indemnities made by the parties herein and in the other Transaction
Documents shall survive the Closing notwithstanding any due diligence investigation made by or on behalf of the party seeking to rely thereon. In the event that any provision of this Agreement becomes or is declared by a court of competent
jurisdiction to be illegal, unenforceable or void, this Agreement shall continue in full force and effect without said provision; provided that in such case the parties shall negotiate in good faith to replace such provision with a new provision
which is not illegal, unenforceable or void, as long as such new provision does not materially change the economic benefits of this Agreement to the parties.

5.2 Successors and Assigns. The terms and conditions of this Agreement shall inure to the benefit of and be binding upon the respective successors and permitted assigns of the parties. Nothing in this
Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective successors and permitted assigns any rights, remedies, obligations or liabilities under or by reason of this Agreement, except as
expressly provided in this Agreement. The Investor may assign the Investors rights and obligations hereunder, in connection with any private sale or transfer of the Notes or Warrants in accordance with the terms hereof, as long as, as a
condition precedent to such transfer, the transferee executes an acknowledgment agreeing to be bound by the applicable provisions of this Agreement, in which case the term Investor shall be deemed to refer to such transferee as though
such transferee were an original signatory hereto. The Company may not assign its rights or obligations under this Agreement.

5.3
Governing Law; Jurisdiction. This Agreement shall be governed by and construed under the laws of the State of California applicable to contracts made and to be performed entirely within the State of California. Each party hereby irrevocably
submits to the non-exclusive jurisdiction of the state and federal courts in California for the adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated hereby and hereby irrevocably waives, and agrees not
to assert in any suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action or proceeding is brought in an inconvenient forum or that the venue of such suit, action or
proceeding is improper. Each party hereby irrevocably waives personal service of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof to such party at the address in effect for notices to it
under this Agreement and agrees that such service shall constitute good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any manner permitted by law.



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5.4 Counterparts. This Agreement may be executed in any number of counterparts, each of which
shall be deemed an original, and all of which together shall constitute one and the same instrument. This Agreement may be executed and delivered by facsimile transmission.

5.5 Headings. The headings used in this Agreement are used for convenience only and are not to be considered in construing or interpreting this
Agreement.

5.6 Notices. Any notice, demand or request required or permitted to be given by the Company or the Investor pursuant to
the terms of this Agreement shall be in writing and shall be deemed delivered (i) when delivered personally or by verifiable facsimile transmission, unless such delivery is made on a day that is not a Business Day, in which case such delivery
will be deemed to be made on the next succeeding Business Day, (ii) on the next Business Day after timely delivery to an overnight courier and (iii) on the Business Day actually received if deposited in the U.S. mail (certified or
registered mail, return receipt requested, postage prepaid), addressed as follows:

If to the Company:

3189 Airway Avenue, Building C

Costa Mesa,
California 92626

Attn: Robert J. Larsen

and
if to the Investor, to such address for the Investor as shall appear on the signature page hereof, or as shall be designated by the Investor in writing to the Company in accordance with this Section 5.6.

5.7 Expenses. The Company and the Investor shall bear their own costs and expenses in connection with the negotiation, execution, delivery and
performance of this Agreement or the other Transaction Documents.

5.8 Entire Agreement; Amendments. This Agreement and the other
Transaction Documents constitute the entire agreement between the parties with regard to the subject matter hereof and thereof, superseding all prior agreements or understandings, whether written or oral, between or among the parties. Except as
expressly provided herein, neither this Agreement nor any term hereof may be amended except pursuant to a written instrument executed by the Company and the Investor, and no provision hereof may be waived other than by a written instrument signed by
the party against whom enforcement of any such waiver is sought. Any waiver or consent shall be effective only in the specific instance and for the specific purpose for which given.

[Signature Page to Follow]



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IN WITNESS WHEREOF, the undersigned have executed this Agreement as of the date first-above written.



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|Amount of Existing Indebtedness:        |  | $ |  | 
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|Principal Amount of Notes to be Issued: |  | $ |  | 



|                                    |  |                            
|----------------------------------- |  | ---------------------------
|Accepted by                        
|SYNTHETIC BLOOD INTERNATIONAL, INC.
|                                    | 
|By:                                 |  |                            
|                                    |  | Robert J. Larsen, President