### SAT Report PMN Number: P-11-0529 SAT Date: 8/2/2011 Print Date: 5/1/2013

Related cases : Health related cases : Ecotox related cases:

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 1-2 3 Health: PMN substance ; Eco: intact material 2 3 Health: Incomplete incineration product ; Eco: high concern for toxicity o incomplete incineration products to terrestrial organisms

Persistence Bioaccum Toxicity Comments 3 31 2

Exposure Based Review : Health: N o Ecotox: N o
Routes of exposure : Health: Dermal Drinking Water Inhalation Ecotox: All releases to water Fate: ;

P 2 Rec Comments : Comment: N o Commen t
Keywords : Keywords: IRR-E,S,L GI MUTA ONCO DEVEL LIVER KIDNEY SENS AQUATOX -A,CLIVER BLOOD MALE REPRO

IMMUNO ONCO
AQUATOX -C
Summary of Assessment :
Fate : Fate Summary: P-11-0529 FATE:
log Kow = 5.28 (E)
VP = 4.9E-4 torr at 25 C (E) BP = 326 C (E) H = 1.02E-5 (E) log Koc = 5.98 (E) log Fish BCF = 3.15 (E) log Fish BAF = 3.18 (E) POTW removal (%) = 50-90 via sorption and stripping Time for complete ultimate aerobic biodeg > mo Sorption to soils/sediments = moderate Volatilization half-life from a standard river = 130 hrs Volatilization half-life from a standard lake = 66 da Atmospheric Oxidation Half-life = 3.8 hr via OH radical Atmospheric Oxidation Half-life = 160 hr via ozone PBT Potential: P3B3 *CEB FATE: Migration to ground water = moderate

Health : Health Summary: Absorption is poor all routes, based on physical/chemical p roperties. Expect Michael addition to the There is concern for irritation to the eye, skin, and lung, and for disturbances to the GI tract if ingested, based on information in the PMN MSDS. There also are concerns for skin and eye irritation, developmental, liver, and kidney toxicities, respiratory and dermal sensitization, mutagenicity, and oncogenicity from the

. For the potential degradation product, based on test data for the analog concerns are liver toxicity, blood toxicity, and male reproductive toxicity [rat 28-day oralN OAEL = 50 mg/kg, LOAEL = 150 mg/kg with liver toxicity; rat 90-day oral LOAEL = 10 mg/kg based on decreased body weight in males at all doses and liver toxicity and anemia at 200 mg/kg; there were toxic effects on the testes in 2 males in the 90-day oral study that were judged by the reviewer to be indicative of the potential for male reproductive toxicity. There is also concern for immunosuppression and oncogenicity based on data for

Ecotox :
Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 0.20 daphnid 48-h LC50 0.60 green algal 96-h EC50 0.095 fish

_ chronic value 0.009 daphnid

_ chronic value 0.011
algal

_ chronic value 0.038
Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for SAR chemical class = MW 477; log Kow = 5.28 (EPI), ; p H7; 100% active ingredients and mean measured concentrations; hardness <180.0 mg/L as CaCO3; and TOC <2.0 mg/L; high concern for the degradation product

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 1

SARs SAR Class new chemicals category: Ecotox Category

Ecotox Factors Comments:

SAT Chair: J. Kwiat