### Propiconazole Di etary Ex posure and Ri s k Asse ss me n t DP Number: D426495 PC Co de: 122101



## UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON , D.C. 20460
Off i ce of C h e m ic al Safety a nd Poll u t i o n Preve nti o n



### M E MORANDUM
Date : December 1 , 20 15


### SUBJECT: Prop ico n azo le: Acu te and Chronic Aggregat e Dietary (Foo d and Drinki ng Wate r) Expos ure and R i sk Assessme nt s fo r the Ne w Use of Propiconazole on Dill , Crop sub g roup SB Leafy 

### Brassica greens , Radi s h , Ti Palm , Waterc ress , and the Ex p ansion of F ruit , sto ne , gro up 12 -1 2, a nd Nut , t ree , group 14-1 2.

PC C ode: 122101 Deci sio n No.: 496175 DP Barcod e: D4 26495 R

eg istration No .: I00-617 , I 00-1 178 , I00-1312 , 

### & 100-1324 Petition No.: 4E832 I 

### Regulatory Action: Section 

### 3 Case No.: 3 125. Ri sk Assessment Type: Di e tary assessmen t TXR No.: 

### NI A CAS No.: 60207-90-1 

### MRID No.: 

### N IA


### FROM:

THROUGH : 40 C FR : 

### § 180.4 3 4


### Thurston G

. Morton , Chemist 

# rj//

# ~/-­ Risk Assessment Branch IV (RAB

# / • H ea lth Effec ts Di vision ( H ED ) (7509 P )
J uli e 

## L. Van A ls tin e, 

## MPH , Environmental Heal th Sc ie nti st ( '

.

# ~**~** Meheret Negussie , C hemi st 

## He;,,. evd

# ~ff<.i:!..**~** Dietar y Expos ure Sc ie nce A d v isory Co uncil (DltSAC) HED (750 9P )
An d
Eli ssa Reave s, Ph

. D

. , C hi ef Risk Assessment B ranch 4 , HED ( 7509P)


### TO: Sidney Jackson/Barbara Madden Risk Integration, Min or Use E merge ncy Resp o n se Branch Registration Di vision (7505 P)

Thi s document provides the HED 's dietary exposure ri sk assessme n t for the n ew u ses of propicon azo le.

Page I of 2 6

### Propiconazole Dietary Exposure and Risk Assessment DP Number: 0426495 PC Code: 122 101



### Executive Su mm ary Propiconazole acute and chronic aggregate dietary (food and drinking water) expos ure and risk assessments were conducted using the Dietary Exposure Evaluatio n Model software w ith the Food Commodity Intake Database DE EM

- FCTD , Vers ion 3 .16 , which incorporates 2003-2008 consumption data from USDA's Nationa l H ea lth and Nutrition Examination S urvey, What We Eat in America , (NHANES / WWEIA). The analyses were performed to sup port the new use s on dill, leafy 

## Brassica greens crop s ubgroup SB , radish , ti palm , watercress, and th e ex pansion of fruit, stone, group 12-12 , and nut , tree , group 14-12.
This memorandum was reviewed by two peer rev i ewers of the DESAC , per DESAC SOP 2012.l.
Attached are acute and chronic dietary risk assessments for these new uses. This dietary asses s ment is for r es idue s of propiconazole and its metabolites convertible to 2,4- dichlorobenzoic acid (2,4-DCBA), expressed as propiconazole equivalents. The common metab oli te s
- triazole, triazolylalanine (TA), triazolylacetic acid (T AA), and triazolylpyruvic acid are also residues of concern. Since these are common metabolites from several triazole pesticides and have their own toxicological endpoints, th e risk assessment for triazoles will be assessed separately.
Ac ute Dietary (Food and Drinking Water) Exposure Results and C haracteri zation
An acute dietary analysis for propiconazole was conducted using tolerance levels and I 00 perc e nt crop treated(% CT) for all existing uses and the propos ed new use s. The re su lt s of th e analysis indicate that acute risk from the dietary ex posure (food and drinking water) to propiconazole from the exist ing , proposed , and amended uses did not excee d HED 's level of conce rn fo r the general U.S. population or any population subgroup. At the 95th percentile , the exposure to the general U.S

. population is 26 % of the aPAD; the most hi ghly exposure subgroup (ch ildren 1-2 year old) is 85 % 

### of the aPAD.
Chronic Dietar y (Food and Drinking Water) Exposure Results and Characterization
A chronic diet ary analysis 

## fo"t prop iconazo l e was conducted using tolerance levels for some commod iti es, average field trial residues for the remaining commodities , and l 00 % CT for all existing uses and the proposed new uses. Results of the analysis indicate that chronic ri sk from the di etary exposure (food and drinking water) to propiconazole from the ex is ting , proposed , and amended uses did not exceed HED's level of concern for the general U.S. population o r any population subgroup. The expos ure to the ge neral U.S. population is 8.0 % of the cPAD, and the mo s t highly exposed subg roup (children 1- 2 years old) is 25 % 

### of the c PAD.

Page 2 of26

### Propiconazole Di e tary Ex po s ure and Ri sk Assessment DP Number: 042 6495 P C Code: 122101



### Cancer Dietary (Food and Drinking Water) Ex po s ure Re s ults and Characterization
The HED Carcinogenicity Peer Rev iew Co mmittee ( C PRC ) cla ss ified propiconazole as Grou p C

- possible human carcinogen and recommended that for the purpo se of risk characterizatio n the Refere nce Dose (RID) approach should be u sed and would be protecti ve. I. Intro duc tion 

### Propiconaz o le i s a triazole

- type fungi c ide that pro vi de s broad s pec trum di sease control through inhibition of sterol biosynthe s is in fungi. It i s re g is tered to Syngenta Crop Protection fo r th e control of fungal d iseases on a vari ety of crops
. Thi s dietary exposure assessment i s fo r the reques te d ne w u ses. Dietary risk assess m e nt incorporates both exposure and to xic ity of a given pesticide. For acute and chronic a ssess ment s, the ri sk is expressed as a p e rcentage of a maximum
acc eptable dose (i.e. , the dos e which HED ha s concluded will result in no unreas onable
ad verse health effects). Thi s do se is r efe rred to as the PAD. The PAD i s e quivalent to point of departure (POD , N OAEL , LO AEL, e.g.) divided by th e required uncert a inty or safe ty factors

. For ac ute and non-cancer chronic exposures, HED is concerned when estimated dietary risk e xc ee d s 100 % of the PAD. Refere nc es which di sc us s the acute and chronic ri sk assessments in more detail are available on th e EPA/pesticides web s ite: "Av ailabl e Inform ation o n Assess in g Exposure from Pesticides, A User 's G u ide, " 2 l-J UN

- 2 000 , web link: http: //www .regulations.gov/# 

## !documentDetai l ; D = EPA -H

## Q-0 PP-2 007-0780- 000 I ; or se e SOP 99.6 (20-AUG-1999).

T h e mo s t recent die tary ri sk assessment fo r propicon azo le was conducted by T

. Morton (DP 426895 , 12/1 / 1 5).

P age 3 of26Propiconazole Dietary Expo s ure and Risk As sessment DP Number : 0426495 PC Code: 122101



### II. Resid u e Information

S ummary of Metabolites a nd Deg radat es to b e incl u ded i n the Risk Assess ment a nd To lerance Ex p r ession.
Matrix For Risk Assessment* For Tole rance Expression
Plants Parent plus all metabolites convertible to 2 ,4- Parent onl y DC BA
Rotational crop Parent plus all metabolites convertib le to 2 ,4- Parent only DC BA
Livestock: Parent plus all metabolites convertible to 2 ,4- Parent only DCBA
Water Pare nt onl y 

### NIA Note: For all triazole-containing pesticides , the triazole-containing metabolites 1 ,2,4-T , TA , and T AA s hould also b e included a s residues of concern for risk assessment purposes only for plant and livestock commodities. Since these metabolites are common to the entire class oftriazole-derivative fungicide s and becau s e of differential toxicity between the metabolites and the various parent compounds , risks associated with exposure to 1 , 2 , 4-T and to T 

### A!T AA are addres sed in s eparate risk a ss essment documents
.

* MI = 5-[(4-chlorophen y l)meth y l]-2-methox y l-2-methyl- l- ( 1 H-1 ,2, 4-triazol-1- y lmeth y l )

- l-cy clopentanol: M 11 

## = 5-[(4-chloropheny l)methoxyl]-2 , 2-dimethyl-1-( 1H-1 ,2 , 4-triazol-1-ylmethyl)- 1- cyclopentanol ; M 12 

## = 5-[ ( 4-chloro phen y l ) meth y l]-2-carbox y l-2-methyl-1- ( I H-1 ,2.4-triazol-1- y lmeth y l ) -l-c yclopentanol: M31

= (Is• , 3R* , 5S*)-3-hydroxy-cis-metconazole ; 1,2 ,4-T = 1 H-1 , 2,4-triazole ; T AA = 1 H-1 , 2 ,4-triazol-1-yl acetic acid ; TA = 2-amino-3-(1 H-1 , 2 ,4-triazol-1-yl)propanoic acid.


### Residue Data used for Acute and Chronic Assessme nts:
The acute asses s ment was based on the assumption of tolerance

- level residues for all
com moditi es with existing and proposed tolerances and 100% CT for all commodities. The chronic assessme n t was based on tolerance-level residues for some commodities , ave ra ge field trial residues for the remaining commodities , and I 00% CT. The existing tolerances are listed in 40 CFR 

## § 180. 434. D EEM default processing factors from DEEM (Version 7.81) were used fo r all processed commodities that do not have individual to lerances except for citrus juices which were reduced to l s in ce no concentrat ion of propiconazole residues occurred. Residues of propiconazole and metabolites do not concentrate in canola refined oil (processing factor of 0.2x). Canola oi l processing factor was u sed fo r sesame oi l also. Field trial data were translated from the representativ e commodities to the non -r epresentative commodities according to HED SOP 2000 .1 :

" Guidance for Translation of Field Trial Data from Representative Commodities in the Crop Group Regulation to other C ommodities in Each Crop Group/ Subgroup. "

Page 4 of26

### Propiconazol e D ietary Exposure and Risk A s sessme nt DP Numb er: D426495 P

C Code : 122 101



### New Uses and Crop Conversio n s a ssoc iated wi th this petition:
Tho se co mmoditi es to be added to 

## § 18 0.43 4 (a)( l ) are:
Dill weed , fresh leaves
........................................................... 3 0 ppm Dillweed, dri ed le aves
.... ...... ... . . ... .. . .. ...... . .. . ...... . .. . . . .... . ... . ..... 80 ppm Dill , seed

... . . ... ..... ..... .. .. .. ..... .. ...... . ......................................... 15 ppm Brass i ca , lea fy greens, s ubgroup 

## 58

.. .... ..... ............... .. ....... .. 20 ppm T i palm , leaves
.......... . ................. .. ................ . ......... . ........ . .... l 0 ppm Ti palm , roots

................ .. ........................ .... ......... . . . ........ . .. 0.30 ppm Watercress

. . .. .. . .. .. ..... .. ......... .. ...... ... ........ . ...... .. . . ...... .... ..... .... 6.0 ppm Frui t, sto ne , gro up 1 2 -1 2 , exce pt plum

................................ 4

. 0 ppm Nut , tre e, group 14-1 2

........................................................ 0 .10 ppm R ad i s h , top s
...... .. .. ........ .. ...... .. .. .. . 0.20 ppm (9 ppm u sed for acute*) R adi s h , roots

............................ 0.04 ppm (0.2 pp m u sed for acute*)
*propiconazole residues convertible to 2.4-d ichlorobenzoic acid (2,4-DCBA)


### In addition , a tol eran ce of 4.0 ppm ha s been pro po sed for tea in a prev iou s acti o n 

## (T. Morto n , 426896 , 1211 

### II 5)

. 

## Propiconazo le ex i sting to lerances:
§ 

### 180 .43 4 Propi co n azo le; t o l

eran ces fo r re s idue s. (a) 

## General

. Tolerances are es tabli s hed for res idu es of propic o naz o le , includin g it s metabo lite s and d egradates , in or o n the commodities in th e table below. Co mplianc e with the tol eranc e level s spec ifi ed below is to be d e termined by meas urin g o nl y tho se propiconazole res idu es co n vertibl e to 2,4 -di ch l o rob e nz o ic acid (2 , 4- DCBA ), expressed as the sto ichi o metric e quivalent of propic o nazol e , in or on the commodities in th e tabl e below:


## r-- -- - - 

## - - - 

# -r-- Co mm o dit y Part s per milli o n 

# I Banana 

# I 0.2 jBarley , bran translated to oat bran 

# I 6 .0 jBarley , g rain 

# [ 

# -- 3.0 !Bean , dry seed 

# I 0.40 ls e an , s nap 

# I 0

. 70 !Bean , succu le nt she ll ed 

# I 0. 10 I B e et, g arden , roots 

# I 0

. 30 J Beet, garden ,

### t~ 

# I 5.5 

# --r

-- B eet , s u g ar, mo lasses 1.5 

### j seet , s ugar, roots 

# I 0.3 !B eet , s ug ar, top s 

# -- -- 

# -- 

# -r 10

Page 5 of26

### Propiconazole Dietary Ex posure and Risk Assessment DP Number: D426495 PC Code: 122101

[Bushberry, subgroup 13-07 8 1.0 

# I l caneberry, subgroup l

-3

- -0

- 7

_ A

_________________ ,_

_______ 1

_ .0

## ~t.~s 

# @ [C

attle, fat

## ~ t cattle, kidney 2.0 ! cattle , liver 2 0 1 Cattle , meat

# O.~S !cattle, meat byproducts , except liver and kidney 0.05 !Cilantro , leaves 13



## --- Citrus , oil I 

### 000 [Co rn , field, gra in 0.2 ! corn
. pop , grain 0.2 !com, sweet , kernel plus cob wi th husks

### em~ 0.1 

# I Fruit, citrus , grou p 10-10 8.0 !Fruit , stone , group 12

-. -

e
.

- xc

_ e

_ p

_

t p

- l

- um

----------------;.i--------4

- .

- 0 1 

### !Goat , fat

-- 

# -----------1 0.05 1 !Goat , kidney

------ 

# I 2.0

. !Goat , liver 2.0 !G

oat, meat

-- 

# r o. osl j Goat , meat byproducts , except liver and kidney 

# O.osl jH

og , kidney 0.2 [Hog, li ver 

# Q.21 !Horse , fat I 

# o fill !Horse, kidney 

# iO !H

orse , liv er
-------- I 2.0 lr- H

- o

- rs

_ e

_ , -

m

- e
-

at

----------------------1 0.05 

# I l i--------1 

### Horse, meat byproducts, except liver and kidney 0.05 [ Leaf petioles subgroup 48 ----------1 5.0 Low growing berry subgroup I 

### 3-07G, except cranberry

### ~ I 

### .3 J Milk

___ .;______
________ ,!

_____ 

## Q.05
jMushroom I 0.1 I Nut , tree, group 1 4 

# I 0.1 l oat , grain 

# I 3.0 !Onion , bulb subgroup 3-07A [ 0.2 l onion, green , subgroup 3 -078 

# I 9.0 !Parsley , fresh leaves 

# I 13 

# f Parsley, dried leaves**~[** 

### 35 J reanut 

# I 0.2 l reppennint, tops I I 

### 0.0 jPineapple 

# I 4.5 

# I 

# I Pistachio 

# I 0.1 

# I

Page 6 of26

### Propi co nazo le Di e tary E xpo sure and Ri sk Asses sme nt DP Number: 0426495 PC Code : 1 22 101



## -- 

# -----, jPlum 0.60 !R

apeseed s u bgro up 20A 

# I 0. 3 0 

# [R

--- Ri ce, bran 

# I 1 5 j Rice , gra in 

# I 7.0 !R

ye, br an 

# I 0.6 [Rye , gra in - 

# I 0 .3 js h e ep , fa t 

## --- 

# I 0.0 5

' Sheep , k idn ey 

# I 2.0 [S h ee p , li ver 

# I - 2 .0 [ S h ee p , m e at 

# I 0.0 5 S h ee p , m eat byp ro duc ts , exce pt li ve r and kidn ey 

# I 0.05 lso rghu m, grai n , grain 

# I 3. 5 !soy bean , see d 

# I 2.0**~----** 

### !S pearmi nt , to ps 

# I 10

.0 r---- 

### Sugarcane , cane 

# I 0 .4 ! To mato 

# I 3. 0 !vege ta bl e, fo liage of legum e, group 7 

# I 3 0 Wheat , bran 

# I 0.6 jwh eat, gra in 

# I 0.3 

### (b) 

## Sec ti on 18 em er ge n cy e xemptio ns
. Tim e -limited tol e ranc es are establi s hed for res idu e s of propiconazol e ( 1- [ [2- (2 ,4-dichl orophen y l) -4-prop y l-l , 3 -dio xolan-2- y l]
me th y l]-1 H-1 ,2, 4-triazol e) and its meta bolites detem1ined as 2 ,4

- dichlorob enzoic acid and ex pre ssed a s pare nt co mp ound , in co nn ection with u se o f the pesticide und e r section 18 emergency e xemptions granted by EPA. The toleranc es will expire and a re re vok e d on th e dates s p ecifi e d in th e foll o win g tabl e: jc o mm od ity 

# -I Pa rts pe r mill io 1

- 1

- 

# -r -**E-;pi a~** **;;;o~o;d~tc ~\** **ca -----.----------** **0** 

### 12 / 31 / 16 !Nec t a

r ine 2 .0 lr----------------- 1

- 2

- /3

_

1 _/

1

- 3 1**~-------.-----------** 

### jP

eac h 2. 0 1 2/3 1 / 13 

### (c) 

## To le ran ces w ith regio nal regis trat io ns. A to l e rance w ith re gional r e gistration , a s d e fined in § 180. l (1 ) , is e stablished for re sidue s of 1-[[2

- (2,4-dichloropheny l)-4-prop y l

1 , 3 -di ox olan- 2

- y l]meth y l]-1 H-1 ,2, 4-triazol e and its metabolite s determined as 2 ,4

- di c hlorobenz oi c acid and expre ss ed a s pare nt c o mp o und , in o r o n the follo w ing
c o mmoditi es:

Co mm o di ty Parts per mill ion**ry** 

# ___ _ I 1.0 1

### R

ice, wild, grai n 

# I 0. 5

Page 7 of2 6

### Propiconazole Dietary Exposure and Risk Assessme n t DP Numbe r : D 426495 PC Code: 122101


### Average Field T rial Residues Used in the Chronic Dietary Exposure Assessment:

Beets , garden and sugar.
............. 0.12 ppm Carrot.

.................................0.10 ppm O ni on , gree n and leek, chi ve, shall ot leaves
................ 2.43 ppm Parsley , fresh leaves

.................. 3.65 ppm Crop Group 48

.................. . ..... 1.01 ppm Soybean seed

... ......... ... ........ ... .0.26 ppm Tomato

.................................0.791 ppm Grapefruit..

............................ 1.18 ppm Lemo n
......... . .................... . ... I

.79 ppm Lime

........................ . ........... 2.34 ppm Orange

................................. 2.34 ppm Cherry

.................... . ......... . ... 1 .08 ppm Apricot, nectarine , peach

............0.989 ppm Plum

.................................... 0.192 ppm B l

ueberry

...............................0.35 ppm Cranberries

.............................. 0.32 ppm Other small berries

..................... 0.36 ppm Strawberry

.... .. ......... .. ..............0.35 ppm Almond

.................................. 0.038 ppm Com, field and pop
..................... 0.036 ppm Rice

....................................... 1.49 ppm (rice bran used bran tolerance) Sorghum

.................................. 1.27 ppm Wheat

................. . ...................0.043 ppm (wheat bran used bran tolerance) Pineapple

................ . ........ . ....... I. 

### I I ppm Sugarcane

..... . .......... . ......... . ...... 0.12 ppm Oilseeds

.................................... 0.081 ppm Dill seed

....... . .......................... 2.447 ppm Di ll weed, dried leaves
.. . ............... 23.1 18 pp m Brassica leafy greens s u bgroup SB

.....4.078 ppm R

adis h , tops

............................... 2.005 ppm Radish, roots

............................... 0.057 ppm Watercre ss
.............................. ... . 1.698 ppm


### T h e US D A Pesticide D ata Prog ra m (PDP ) m onito re d pestic ide res id ues in catfis h in 2 008, 2009, and 20 l 0. PDP analyzed 1279 catfish samples for pro p iconazole residues. The r e were no d etec t ab le propi co n az ol e res idu es. As a res ult , resi du es in fis h were n ot included i n the assessment.
III. 

### Pe rc e nt C rop T rea ted
l 00 % CT was ass ume d fo r all cro p s.


## IV

. D rinkin g Wa te r D ata
The drinki n g wate r residues used in the dietary risk assessment were provided by the Env ironm e nt a l Fate an d Effects D i v is ion (EFED) in the fo ll ow i ng memoran dum: "Drinki ng Water Assessment for Proposed New Uses of Propiconazo le o n D ill , R

ad i sh, Leafy Brass ica S u bgro u p SB, Watercress, T i palm and Crop Group

Page 8 of26

### Propiconazole Di etary Ex po s ure and Risk Assessment DP Number: 04 26495 PC Code: 122101



### conversions fo r Sto ne Fruit Gro up 1 2- 12 and Tree Nu t Group 14-12. " (I. 

### Abde l -Saheb, 

## 05 / 27/ 15 , 0423648) and incorporated direc tl y into thi s di etary assess ment. T his assessment incorpo r ate d new model s implemented s inc e the previous E DWCs

. Water resi dues were directl y incorporated in D EEM -FCID into the food categories " water , direc t, all sources" and "water , indirect, all so urce s
. "

The estimated drinkin g wat er conce n trat io ns fo r p r opico nazole are: 

## 37.9 ug /L for use in the ac ute di e t ary expos ure assess ment 

## 35. l ug /L for us e in the c hro ni c d ietary expo s ure as sess men t.

Table I. Est imated Drinkin g Water Concentrations (E DW Cs) for propo se d new uses and previously registered turf. Use o n Turf New Uses S u rface water S urfa ce wate r S u rface water 2006 Modeli ng 20 15 Mo d e li n g 20 1 5 Mod e ling ( PRZM/ EXAMS) * (S W CC)** (SWCC) Dill Ra dis Watercre Ti Stone 

### h SS 

### Palm Fruit(l2- 12) Peak (ppb) 76.5 Peak (1-in -1 0 yr) 

### 35.2 2.84 18.4 15 .9 8 .69 3.55
Annual Mean ( ppb) 37.5 365 -d ay Avg ( I- in- 

### 18

. 6 1. 35 2.6 8 3.65 2.25 1.61 10 y r)

30-Year Mean (ppb) 26.4 Entire Simulation 14

.4 

### 1.04 1.76 2 .61 1.69 1.35 Mean I

-**~ -~** **=~~** 

# - 

# - -- SC I- PRZM-GW *** PRZM-GW G roundwater GROW E DW Cs ( ppb) Peak Co ncentration 37.9 1.84 2.47 2.47 2.47 3. 17 ( ppb) Po st-B reakthrough 35. 1 1.6 6 2.23 2.23 2.23 2. 85 Mean Concentration 0

. 64 (ppb) E ntire Si mu lation 26.4 1. 25 1.67 1.67 1.67 2.14 Mean Concentration (ppb)

• Based o n PA turf sce nari o ( hi ghes t m o del o utpu t )

. •• Two sce nari os were run and high es t m o del o utput is prese nt ed in thi s table

. For the S WC C m o d

el ; the following available turf scenari os \\Cre u sed : FL. and P A The Penn sy lvania scena r io ga ve th e hi gh es t EDW Cs. ••• Fo r the PRZ'.\l-GW model : the fo ll o win g available scenari os were u sed : FLpotato. FL ci tru s . GA coas tal

. ruid NCcoas tal. and Wlsand

. The Wl sa 11d sce nario gave th e hi ghe st ED WC s.



### The hi g he st e s tima t es from gro und water (acu te , 37

. 9 ppb and chronic , 35 . l ppb) are d irectly entered into the ex pos ure m odel to assess th e co ntri bu tio n s from drinki n g water.

Page 9 of26 Tree Nut (14-12)

4.88
2.68

2.36

4.41
3.99

2.99

### Propiconazole Dietary Exposure and Risk Assessment DP Numbe r: 04 26495 P

C Code: 12210 

### I



### V. D E EM-F C ID Program and Cons umption Information Prop iconazole acute and chronic d ietary exposure assessments were conducted using the Dietary Expos ure Evaluation Mode l software w ith the Food Comm odity Intak e Database DEEM-FC ID , Version 3.16, wh ich incorporate s 2003

- 2008 co n sumption data from US DA 's National He a lth and Nutritio n Exami nation Survey , What We Eat in America , (NHANES/WWElA)

. The data are based on th e reported consumption of more than 20 , 000 indiv id u als over two non-con sec uti ve survey days. Foods "as consumed" (e.g., apple p ie) are linked to EPA-defined food commodities (e.g., apples, peeled fru it

- cooked; fresh or N / S; baked; or wheat flour

- cooked; fresh or N/ S, baked) using publicly available recipe translation fi les developed joint ly by USDA/ ARS and EPA. For c h ron ic exposu re assessment, consumpt ion data are averaged for the entire U .S. population and
w ithin population subgroups , but for acute ex po s ure assessment are retai ne d as individual
co n sumption events. Based on analys is of the 20 03-2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, H ED concluded that it is mo st ap propriate to repo r t risk for the following population s ubgroups: the ge neral U.S. population, all infants ( < l year old), child r en 1-2 , children 3 -5 , children 6-12, youth 13- 19 , adu lts 20-49 , fema les 1 3 -4 9 , and adu lt s 50-99 years o ld.
For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) o n the food commodity residue list i s multiplied by the average daily consumption estimate for that food/foo d form to produce a re s idue intake estimate. The resulti n g residue intake estimate for eac h food/ food form is summed with the residue intake esti mates for all other food/food fo rm s on the commodity residue li st to arrive at the tota l average estimated exposure. Exposure is expressed in mg/kg body we igh t/day and as a percent of the cPAD. Thi s procedure is performed for each popu l ation subgroup.
For acute exposure assessments , indi v idual one-day food consumption data are used on an indi vidua l-b y-individua l bas i s
. The reported consumption amo un ts of each food item can be multiplied by a residue point estimate and summed to obta in a total daily pesticide exposure for a dete rmini stic exposure assess ment , or " matched " 

## in multiple r andom pair i ngs with residue values and then summe d in a probab ili stic assessment. The resu ltin g distribution of exposures is exp ressed as a percentage of the aP A D on both a user (i.e., on ly those who reported eating relevant commodities/food forms) and a percapita (i .e ., those who rep orted eating the relevant commod it ies as well as tho se w ho did not) ba s is. In accordance with HED policy, per cap ita exposure and risk are reported for all tiers of analysis

. However , for tiers 1 and 2 , any sign ificant differences 

## in u ser vs. per capita expo s ure and ri s k arc specifically ide ntified and note d in the ri sk assessment.
VI. Toxicological Information
HED 's Hazard Identification Assessment R eview Comm ittee ( HIARC) concluded that the tox icology databa se for propiconazole is complete for Food Quality Protection Act (FQ P A) assessment. Endpoints and dose res ponse have been se lected for acute and chron ic dietary ex po s ure s.

Page 10 

### of26

### Propiconazole Dietary Exposure and Risk Assessment DP Number : D426495 PC Code: 122101



### The H ED Carc inogenicity Peer Review Committee (C PRC) class ifi ed propiconazo le as Group C

- poss ibl e human carc in oge n and reco mmended that for the purpose of risk characterization the referen ce Dose (RID ) approach sho uld be used a nd wo uld be protec ti ve.
Tab le I Summa ry of Tox ico logical D oses and Endpoints for Propicon azo le for Use in Di e tary Expos u re Ri s k Assess ment s

Expos u re/ Point of U ncc rta inty/FQPA RID , PAD , Leve l Study a nd Tox ico logica l Scena rio D epartu re Safety Factors o f Conce rn Effects Acute NOA EL= UFA = !Ox Acu te RfD = 0 .3 Ac ute neurotoxicity stu dy Dietary 30 UF11 = IO x mg/kg/day LOA EL = I 00 mg/kg/day based (G eneral mg/kg/ day FQPA SF= Ix on cli nica l signs of tox ic ity Population , aPAD =0.3 (pi loerection in one male , including mg/kg/day diarrhea in one female, tip toe Infant s and gait in 3 fema les). C

hildren ) Acute NOAEL = UFA = IOx Acute RID = 0.3 Deve lop m e nt al T ox ic ity Study

- Dietary 30 UF11 = !Ox mg/kg/day Rats. (Fe male s 13- mg/kg/day FQPA SF= Ix LOAEL = 

### 90 mg/kg/day based 49 years of on increased incidence of age) aPAD =0.3 rudimentary ribs, un-ossified mg/kg/day ste mebrae , as well as increased incidence of shortened and absent renal papillae and increas ed cleft palate. Chronic NOA EL = UF A = IOx Chronic RID = 0.1 24 -month o ncoge ni c ity study Dietary (A ll 10 UF11 = !Ox m g/

kg/day on CD- I mice. Populations) mg/kg/da y FQPA SF= Ix LOAEL = 50 mg/kg/day based cPAD = O.I on non-neoplastic live r effects m

g/kg/ da y (inc reased liver weight in males and in c rease in liver lesions: masse s/raised a rea s/ s we ll ings/nodular areas main l y)

. Cancer (o ral , dermal, Classification: Group C , possible human carcinogen , RID approach for risk inhalation) characte ri zation. Po mt of Departure (POD) = A data pomt or an estimated pomt that 1 s derived from observed do se -response data and used to mark the beginni ng of extrapo lat ion to determine ri sk associated with lower environmentally relevant human exposures
. NOA EL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncerta in ty factor. UF " = extrapo lation from animal to human (interspecies). UF11 = potential variation in se nsi tivity among members of the human population (intraspecies). UFoa = to account for the absence of key data (i.e., lack ofa critical study). FQPA SF = FQPA Safety Facto r. PAD = population adj u sted dose (a = acute , c = chronic). RID = reference dose. NIA = 

### not applicable.


## V II. Resu lt s! Di sc us s ion
As stated above , for ac u te and chronic assessments , HED is concerned when dietary risk exceeds 100% of the P A D

. T he DE EM -FC ID ana lyses es tim ate the dietary expos ure of the general U.S. population and vari o u s populatio n subgro up s. The results reported in Tab les 2 and 3 are fo r the ge ne ral U.S

. Po pul at ion , a ll in fan t s (< 1 year old) , c hildre n 1- 2 ,

Page 11 of26

### Propiconazole Dietary Exposure and Ri sk A ssess ment DP Number: D426495 PC Code: 122 101



### c hildren 3-4, ch ildren 6- 12 , y outh 13- 19 , fema les 1 3-49, adults 20-49 , and adults 50-99 years o ld

. At the 95 111 

### percenti le , the ac ute d ietary exposure (foo d and drinkin g water) to the ge neral US populati o n i s 26 % of the 

## aP AD , and th e exposure to the most highl y exp ose d
s ub group , chi ldre n 1-2 years o ld , i s 84 % of the aPAO

. The chronic dietary exposure to the general U.S. pop ulati o n i s 8.0 % of the cPAD , and the exposure to the mo st hi g hly exposed s ubgroup , c hildren 1-2 year s old , is 25 % of the c P AD. All the dietary risk estimates are below 100% of th e PA Ds.
T hese anal yses are highl y conservative di etary exposure as sess m ents. Furth er r e finem e nt to the analyses could be made through the use of anticipated residues , incorp oratio n of p ercenta ges of crops treated with propiconazo le , and/or monitoring data that b etter r e fl ect res idue s at the time of con s umption. S in ce ri sk estimates are well be low H ED ' s le ve l of concern , a more hi g hly refined analysis is n ot needed at thi s t ime.
Result s of Ac ute Di etary (Foo d and Drinking Water) Ex po s ure Analysis

Tab l e 2. Results of Acute Dietary Exposu re Analysis for Food and Drinkin2 Water 95th Percentile Population Sub2roup aPAD (m!?/k2/ day) Expos ur e ( m2/ k2/ da y) %a PAD G ene ral U.S. Population 0.0787 19 26 All Inf ants( < I year o ld ) 0

. 11135 2 37 Ch ildre n 1-2 years old 0.252947 84 C hildren 3

- 5 yea r s old 0.193824 65 C hildren 6- 12 years o ld 0

. 3 0.106303 35 Youth 13- 19 years o ld 0.073 9 78 25 Adults 20-49 ye ars old 0.061858 21 Adults 50-99 years o ld 0

. 053388 

### 18 Females 13-49 years old 0.060911 20 1

### Th e popul atio n s ub gro up with th e hi g he s t esti m ated chro ni c dietary (food + drinking water) exposure and ri s k is indicated by bold text


### R es ult s of Chronic Dietary (Food and Drinkin g Wate r) Ex p os ure Analysis

Table 3. Re s u l ts of C hro ni c Dietary Ex p os ure Ana lys is for Food and Drinking Water Popul atio n Sub2roup cPAD (mg/ kg/da y) Exposure (mg/kg/ day) %cPA D Gen eral U.S

. Popul a ti on 0.00 801 2 8.0 All Infant s( < 1 year o ld ) 0.0 111 38 11 C hildren 1 -2 years o ld 0.024493 25 Chi ldren 3-5 ye ars o ld 0.019799 20 C hildren 6-12 years old 0.1 0.010409 1 0 Youth 1 3 -19 years old 0.006435 6.4 Adu lts 20-49 ye ars o ld 0.006739 6.7 Ad ults 50-99 years o ld 0.006270 6.3 Fe males 13-49 years o ld 0.006 176 6.2 1

### The population subgrou p with the highe s t est im ated chron ic dietary (food + drinking water) ex po s ure and ri s k is indi cated by bold text

Page 12 of26

### Pro piconazol e Di etary Exposure and Ri s k Assessment DP Number: 04 26495 PC 

### Co de: 122101



### VI II
. C h a rac te riza ti o n o f Inputs/O utputs
The acute a na ly s is ass ume d tolerance-level res idu es, l 00% CT, and empirical o r DEE M default p rocessi ng facto r s. The chronic an a lysis assumed average field trial re sidues for some commodities , tolerance-level res idu es for th e remaining co mmodities , I 00% CT , and empiri cal or DE EM d efau lt pro cess in g fac tor s. Therefo re, these analyses are considered co n servative

. S ince risk estim ates are we ll below HED 's level of conc ern t hey do no t warran t the n eed for further refin e ment at this tim e
. 

## IX. Co nclu s io n s
T h ese di eta ry ana lyses d emo n strate that the req ue sted ame nd e d use for propiconazole wi ll not re s ult in d ietary ri sk est imates that exceed HE D 's leve l of concern for an y of the regulated pop u lation s ubgroups , includ i ng tho se comprised of infants and ch il dre n
. X. List of A ttachm ents
Attachment l

. Ac ute Food p lus Water Re s idu e I nput file. Attachment 2

. Ac ute Re s ult s fi le. Attac hment 3. Chronic Food plu s Water Res idue Input file. A tt achme n t 4. Chronic R es ult s file.

Page 1 3 of26

### Propiconazo l e Dietary Expos ure a nd Risk Assessment DP Number: D 426495 P

C Co de: 1 22 10 I



### Attac hm e nt 1. Ac u te Food plus Water Residue Inpu t fi le.
Filename: C:\Users\tmorton\Documents\My F iles\D EEM Files\122101 Propiconazole\Petition 4E8321 Dill Musta rd Watercress Radish\122101 Acute August 2015.R08 Chemical: Propiconazole RfD(Chronic) : .l mg/kg bw/day NOEL(Chronic): O mg/kg bw/day RfD(Acute): .3 mg/kg bw/day NOEL(Acute): O mg/kg bw/day Date created/last modified: 07-27-2015/09:17:52 Program ver
. 3.16, 03-08-d



## ---- ----- -------------------- ----- ------------- --- ------ --- ---------------------- -- EPA Code Crop Def Res (ppm) Adj .F actors Comment Grp Commodity Name Ill 112
0101050000 lAB Beet, garden, roots 0.300000 1.000 0101050001 lAB Beet. gard en , roots-babyfood 0.300000 1 .000 01010S2000 lA Beet, sugar 0.300000 1.000 01010S2001 lA Beet, sugar
- babyfood 0.300000 1.000 0101053000 lA Beet, sugar, molasses 1.500000 1.000 01010S3001 lA Beet, sugar, molasses -babyfood 1.500000 1 .000 0101078000 1AB Carrot o.2soooo 1.000 0101078001 lAB Carrot-babyfood 0.250000 1.000 0101079000 lAB Carrot, juice 0.250000 1.000 0101314000 lAB Radish, roots 0.200000 1.000 Full comment: What would be for parent plus metabolites 0101316000 lAB Radish, Oriental, roots 0.200000 1

. 000 Full comment: What would be for pa rent plus metabolites 02ooos1000 2 Beet, garden, tops 5.500000 1.000 020031SOOO 2 Radish, tops 9.000000 1.000 Full comme nt: What would be for parent plus metabolites 0200317000 2 Radish, Oriental, tops 9.000000 1.000 Full comment: What would be for parent plus metabolites 030116SOOO 3A Garlic, bulb 0.200000 1.000 030116S001 JA Garlic, bulb-babyfood 0.200000 1.000 0301237000 3A Onion. bulb 0.200000 1 .000 0301237001 3A Onion, bulb-babyfood 0.200000 1.000 0301238000 3A Onion, bulb, dried 0.200000 9.000 0301238001 3A Onion, bulb, dried -baby food 0.200000 9

. 000 0301338000 3A Shallot, bulb 0.200000 1.000 0302103000 3B 0302198000 3B 0302239000 3B 0302338SOO JB 0401248000 4A 0402076000 4B 0 4 0208SOOO 4B 040208S001 4B 0 40208600 0 4B 0402087000 4B 0402152000 4B 04023 2200 0 4B 0402367000 4B 0502063000 SB OS02070000 SB 0502117000 SB OS02194000 SB OS02229000 SB OS02318000 SB 0502389000 SB 0600347000 6 0600349000 6 0600349001 6 06003SOOOO 6 06003 S00 01 6 0601043000 6A 0601043001 6A 0601349SOO 6AB 0602031000 68 0602033000 6B 0602037000 6B 0603030000 6C Chive, fresh leaves Leek Onion, green Shallot, fresh leaves Parsley, leaves Cardoon Celery Celery-babyfood Celery, juice Celtuce Fennel, Florence Rhubarb Swiss chard Broccoli raab Cabbage, Chinese, bok choy Collards Kale Mu stard greens Rape greens Turnip, greens Soybean, seed Soybean, soy milk Soybean, soy milk-babyfood or in Soybean, oil Soybean. oil-ba byfood Bean. snap, succulent Bean. snap, succulent

- babyfood Soybean, vegetable Bean. broad, succulent Bean. cowpea, succulent Bean, lima, succulent Bean, black, seed 9.000000 9.000000 9.000000 9.000000 13.000000

S.000000 5.000000 5.000000 S.000000 S.000000 5.000000 5

. 000000 5.000000 20.000000 20.000000 20.000000 20.000000 20.000000 20.000000 20.000000

2.000000 2.000000 2.000000 2.000000 2

. 000000 0.700000 0.700000 0.100000 0.100000 0.100000 0.100000 0 .4 00000



### Page 14 of26 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1 .000 1 .000 1

. 000 1.000 1.000 1.000 1 .000 1.000 1.000 1 .000 1

. 000 1. 000 1.000 1

. 000 1. 000 1. 000 1.000 1.000 1. 000 1.000 1.000 1. 000 1. 000 1. 000 1.000 1.000 1 .000 1.000 1.000 1.000 1.000 What w
1. 000 What w 1.000 1.000 What w 1.000 What w l.000 1.000 1.000 1.000 1.000 1

. 000 1.000 1.000 1.000 1 .000 1 .000 1. 000 1.000 1.000 1 .000 1 .000 1.000 1.000 1.000 1. 000 1.000 1.000 1.000 l. 000 1.000 1.000 1.000 1. 000 1 .000 1.000 1.000 1

. 000 1 .000 1.000 1.000 1

. 000 1.000 1 .000 1

. 000

### Propiconazo le PC Co de: 

### 122101

0603032000 6C 0603034000 6C 0603035000 6C 0603036000 6C 0603038000 6C 0603039000 6C 0603040000 6C 0603041000 6C 0603042000 6C 0603098000 6C 0603098001 6C 0603099000 6C 0603182000 6C 06031S2001 6C 0603348000 6C 060334S001 6C OS01374000 SA OS01375000 SA OS01375001 SA OS01376000 SA OS01376001 SA OS01377000 SA OS01377001 SA OS0137SOOO SA OS0137S001 SA OS01379000 SA OS013SOOOO SA 1001106000 lOA 1001107000 lOA lOOllOSOOO lOA 1001240000 lOA 1001241000 lOA 1001241001 lOA 1001242000 lOA 1001369000 lOA 1001370000 lOA 1002197000 lOB 1002199000 lOB 1002200000 lOB 1002200001 lOB 1002201000 lOB 1002206000 lOB 1002207000 10B 1002207001 lOB 10031SOOOO lOC 10031S1000 lOC 1003307000 lOC 1201090000 12A 1201090001 12A 1201091000 12A 1201091001 12A 1202012000 128 1202012001 128 1202013000 128 1202014 000 128 1202014001 12B 1202230000 12B 1202260000 12B 1202260001 12B 1202261000 12B 1202261001 12B 1202262000 12B 1202262001 12B 12032S5000 12C 12032S5001 12C 12032S6000 12C 12032S6001 12C 12032S7000 12C 1203287001 12C 12032SSOOO 12C 

### Di etary Ex po s ure and Ri s k Assessment

Bean, broad, seed Bean, cowpea, seed Bean, great northern, seed Bean, kidney, seed Bean, lima, seed Bean, mung, seed Bean, navy, seed Bean, pink, seed Bean, pinto, seed Chickpea, seed Chickpea, seed-babyfood Chickpea, flour Guar, seed Guar, seed-babyfood Soybean, flour Soybean, flour-babyfood Tomatillo Tomato Tomato -b abyfood Tomato, paste Tomato, paste-babyfood Tomato, puree Tomato, puree-babyfood Tomato, dried Tomato, dried-babyfood Tomato, juice Tomato, Tree Citron Citrus hybrids Citrus, oil Orange Orange, juice Orange, juice-babyfood Orange, peel Tangerine Tangerine. juice Kumquat Lemon Lemon , juice Lemon, juice-babyfood Lemon, peel Lime Lime, juice Lime, juice-babyfood Grapefruit Grapefruit, juice Pummelo Cherry Cherry-baby fo od Cherry, Juice Cherry, juice-babyfood Apricot Apricot-babyfood Apricot, dried Apricot, juice Apricot, juice-babyfood Nectarine Peach Peach-babyfood Peach, dried Peach, dried-babyfood Peach, juice Peach, juice-babyfood Plum Plum-babyfood Plum, prune, fresh Plum, prune, fresh-babyfood Plum, prune, dried Plum, prune, dried-babyfood Plum, prune, juice 0.400000 0.400000 0.400000 0.400000 0.400000 0.400000 0

. 4 00000 0.400000 0

. 400000 0.400000 0 .4 00000 0.400000 0.400000 0

. 400000 2.000000 2.000000 3 .0 00000 3.000000 3.000000 3.000000 3.000000 3.000000 3.000000 3.000000 3

. 000000 3.000000 3 .0 00000 S.000000 S

. 000000 1000.

S.000000 S

. 000000 S.000000 S.000000 8.000000 8.000000 8.000000 8.000000 8.000000 8.000000 8.000000 8.000000 S.000000 8.000000 8.000000 8

. 000000 8.000000 4

. 000000 4.000000 4

. 000000 4.000000 4

. 000000 4.000000 4.000000 4.000000 4.000000 4

. 000000 4.000000 4.000000 4.000000 4

. 000000 4.000000 4.000000 0.600000 0.600000 0.600000 0 .6 00000 0

. 600000 0.600000 0.600000



### Page 1 5 of26 DP Number: 04 26 495

1. 000 1.000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1.000 1

. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1.000 1. 000 1. 000 1. 000 1. 000 1.000 1.000 1.000 5.400 5.400 3.300 3.300 14.300 14.300

1.500 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1. 500 1.500 1.000 1.000 6

. 000 1 .000 1.000 1.000 1.000 1.000 7.000 7.000 1.000 1.000 1.000 1.000 1.000 1.000 5.000 5.000 1. 400 1

. 000 1.000 1.000 1. 000 1. 000 1. 000 1. 000 1. 000 1.000 1.000 1

. 000 1.000 1.000 1.000 1

. 000 1.000 1

. 000 1.000 1

. 000 1.000 1

. 000 1.000 1.000 1. 000 1.000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1

. 000 1. 000 1.0 00 1.000 1. 000 1

. 000 1.000 1.000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1.000

### Propiconazol e PC Code: 122 101

1203288001 12C 1301055000 13A 1301056000 13A 1301056001 13A 1301058000 13A 1301208000 13A 1301320000 13A 1301320001 13A 1301321000 13 A 1301321001 13A 1302057000 13B 1302057001 13 8 1302136000 138 1302137000 13B 1302149000 138 1302174000 13B 1302191000 13B 1307130000 13G 1307130001 13G 1307131000 13G 1307132000 13G 1307132001 13G 1307359000 l3G 1307359001 13G 1307360000 13G 1307360001 l3G 14 00003000 14 1400003001 14 14 00004 000 14 1400004001 14 1400059000 14 1400068000 14 1400081000 14 1400092000 14 1400155000 14 1400156000 14 1400185000 14 1400213000 14 1400269000 14 1400278000 14 1400282000 14 1400391000 14 1500025000 15 1500025001 15 1500026000 15 1500026001 15 1500027000 15 1500120000 15 1500120001 15 1500121000 15 1500121001 15 1500122000 15 1500123000 15 1500123001 15 150012 4000 15 1500124001 15 1500125000 1 5 1500125001 15 1500126000 15 1500127000 15 1500127001 15 1500231000 15 1 5002 32000 15 1500232001 15 1500233000 15 1500233001 15 1500323000 15 1500323001 15 1500324000 15 1500324001 15 

### Dietary Ex po s ure and Risk A ssess ment

Plum, prune, j uice -babyfood Blackberry Blackberry, juice Blackberry, juice-babyfood Boysenberry Loganberry Raspberry Raspberry

- babyfood Raspberry, Juice Raspberry, juice-ba byfood Blueberry Blueberry-babyfood Currant currant, dried Elderberry Gooseberry Huckleberry Cranberry Cranberry-babyfood Cranberry, dried Cranberry , ju ice Cranberry, jui ce -babyfood Strawberry Strawberry-babyfood Strawberr y, juice Strawberry, juice-babyfood Almond Almond

- babyfood Almond, oil Almond, oil

- babyfood Brazil nut Butternut Cashew Chestnut Hazelnut Hazelnut, oil Hickory nut Macadamia nut Pecan Pine nut Pistachio W

alnut Barley, pearled barley Barley, pearled barley-babyfood Barley, fl our Barley, flour-babyfood Barley, bran Corn, field, flour Corn, field, flour-babyfood Corn, field, me a l Co rn, field, meal

- babyfood Corn, field, bran Corn, field, starch Co rn, field, starch-babyfood Corn, field, syrup Corn, field, syrup-babyfood Corn , field, oil Co rn , field, oil-babyfood Corn, pop Corn , sweet Corn, sweet-ba b yfood Oat, bran Oat, flo ur Oat, flour-babyfood Oat, groats / rolled oats Oat , groats/rolled oats-babyfood Rice, white Rice, white

- babyfood Rice, brown Rice, brown-babyfood



### Page 16 of26 0.600000 1.000000 1

. 000000 1.000000 1

. 000000 1

. 000000 1

. 000000 1.000000 1

. 000000 1.000000 1.300000 1. 300 000 1.000000 1.000000 1.000000 1

. 000000 1.000000 1.000000 1.000000 1.000000 1.000000 1.000000 1 .3 00000 1.300000 1.300000 1.300000 0 .1 00000 0 .100000 0.100000 0 .1 00000 0.100000 0.100000 0 .100000 0. 1 00000 0. 1 00000 0. 10 0000 0.100000 0.100000 0 .10 0000 0.100000 0.100000 0 .1 00000 3.000000 3.000000 3

. 000000 3.000000 6

. 000000 0

. 200000 0.200000 0.200000 0 .2 00000 0.200000 0.200000 0.200000 0 .2 00000 0.200000 0.200000 0

. 200000 0 .2 00000 0. 1 00000 0.100000 6

. 000000 3.000000 3 .0 00000 3.000000 3

. 000000 7.000000 7.000000 7.000000 7 .0 00000 

### DP Numb er : 04 264 95

1.400 1.000 1. 000 1. 000 1. 000 1

. 000 1. 000 1. 000 1 .0 00 1. 000 1. 000 1. 000 1

. 000 1.000 1. 000 1.000 1

. 000 1. 000 1. 000 1

. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1

. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 l

. 000 1. 000 1. 000 1. 1 00 1. 000 1. 1 00 1. 000 1. 000 1. 000 1. 000 1. 000 1.000 1

. 000 1. 000 1. 000 1. 000 1. 000 1.00 0 1.000 1. 000 1. 000 1. 000 1.000 1. 000 1

. 000 1.000 1.000 1

. 000 1.000 1. 000 1. 000 1. 000 1.000 1.000 1.000 1. 000 1.000 1. 000 1. 000 1. 000 1. 000 1. 000 1.000 1.000 1.000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1

. 000 1.000 1

. 000 1

. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1.000 1.000 1.000 1.000 1. 000 1. 000 1.500 1

. 000 1. 5 00 1.000 1. 000 1. 000 1. 000 1

. 000 1. 000 1.000 1. 000 1. 000 1.000 1

. 000 1

. 000 1.000 1.000 1

. 000 1. 000 1. 000 1. 000 1. 000 1 .00 0 1

. 000 1. 000 1. 000 1. 000 1. 000 1.000 1.000 1. 000 1. 000

### Propiconaz ole PC Co d e : 1 22 1 0 1

1500325000 15 1 500325001 15 1500326000 15 1500326001 15 1 500328000 15 1500329000 15 1500344000 15 1500345000 15 150038 1 000 1 5 1500381001 15 1500401000 15 1500401001 15 1500402000 15 1500402001 15 1500403000 15 1500404000 15 1500405000 15 1901118000 19A 1901118001 19A 1901144000 19A 1901249000 19A 1901249001 19A 1902143000 198 2001163000 20A 2001319000 20A 2001319001 20A 2001336000 20A 2001336001 20A 2001337000 20A 2001337001 20A 2003114001 20C 2100228000 21 3100044000 31 3100044001 31 3100045000 31 3100046000 31 3100046001 31 3100047000 31 3100047001 31 3100048000 31 3100049000 31 3100049001 31 3200169000 32 3200170000 32 3200171000 32 3200172000 32 3200173000 32 3300189000 33 3400294000 34 3400295000 34 3500339000 35 3500339001 35 3500340000 35 3500341000 35 3500341001 35 3500342000 35 3500343000 35 3600222000 36 3600222001 36 3600223000 36 3600223001 36 3600224000 36 3600224001 36 3600225001 36 8601000000 86A 8602000000 86B 9500020000 0 9500023000 0 9500023001 0 9500024000 0 

### Di etary E x

po s ure and Ri sk A ssess ment

Rice, flour Rice , flo u r-baby f ood Rice, bran Rice, bran-babyfood Rye, grain Rye, flour Sorghum, grain Sorg hum, s yrup Triticale, flou r Triticale, flour-babyfood Wheat, grain Wheat, grai n-bab yfood Wheat, flour Wheat, flour-babyfood Wheat, germ W

heat, br a n Wild rice Cilancro, leaves Ci l antro, leaves

- babyfood Dill weed Pa r sley, dried leaves Pa r s l ey , dried l eaves-babyfood Dill, seed Flax seed, oil Rapeseed, oil Ra p eseed , oil-babyfood Sesame, s e ed Sesame, seed-babyfood Sesame , oil Sesame, oil-babyfood Coconut, oil-babyfood M

ushroom Beef, meat Beef, meat-babyfood Beef, meac, dried Beef, meat byproducts Beef, meat byproduccs-babyfood Beef, fat Beef, fat

- babyfood Beef, kidney Beef, liver Beef, liver-babyfood Goac, mea t Goac, meat byproducts Goac, fat Goat, kidney Goat, liver Horse, meat Pork, kidney Pork, liver Sheep, meat Sheep, meat-babyfood Sheep, meat byp r oducts Sheep, fat Sheep, fat

- babyfood Sheep, kidney Sheep, liver Milk, fat Milk, fat

- baby food/infant formu Milk, nonfat solids Milk, nonfat solids-baby food/in Milk, water M

ilk, wacer-babyfood/infanc form Milk, sugar (lactose)-baby food / Water, direct, all sources Wa t er, ind irect , all sources Avocado Banana Banana

- babyfood Banana, dried 7.000000 7.000000 15.000000 15.000000 0

. 300000 0.300000 3.500000 3.500000 0.300000 0. 300000 0.300000 0

. 300000 0.300000 0.300000 0

. 300000 0

. 600000 0.500000 13. 000000 13

. 000000 80.000000 35

. 000000 35.000000 15.000000

0.300000 0

. 300000 0.300000 0.300000 0.300000 0.300000 0.300000 0.100000 0.100000 0.050000 0.050000 0

. 050000 0.050000 0.050000 0.050000 0

. 050000 2.000000 2.000000 2

. 000000 0.050000 0.050000 0

. 050000 2.000000 2.000000 0.050000 0.200000 0.200000 0.050000 0

. 050000 0.050000 0.050000 0.050000 2

. 000000 2.000000 0.050000 0.050000 0.050000 0.050000 0

. 050000 0

. 050000 0.050000 0.037900 0

. 037900 10.000000

0.200000 0

. 200000 0.200000



### P

age 17 

### o f 26 1.000 1

. 000 1

. 000 1

. 000 1

. 000 1.000 1

. 000 1. 000 1.000 1

. 000 1

. 000 1.000 1.000 1

. 000 1. 000 1

. 000 1

. 000 1. 000 1.000 1

. 000 1. 000 1.000 1

. 000 0

. 200 0

. 200 0

. 200 1

. 000 1

. 000 0

. 200 0.200 1

. 000 l. 000 1

. 000 1

. 000 1

. 920 l. 000 1. 000 1

. 000 1. 000 1.000 1. 000 1

. 000 1

. 000 1. 000 1

. 000 l. 000 1

. 000 1

. 000 1

. 000 1

. 000 1. 000 1

. 000 1

. 000 1.000 1

. 000 1

. 000 1.000 1

. 000 1

. 000 1

. 000 l. 000 1

. 000 1. 000 1.000 1

. 000 1

. 000 1

. 000 1. 000 1

. 000 3.900 

### DP Number: D4 26495

1. 000 1 .000 1.000 1.000 1 .000 1.000 1

. 000 1. 000 1

. 000 1.000 1.000 1 .000 1

. 000 1 .000 1 .000 1 .000 1

. 000 1. 000 1. 000 1.000 1

. 000 1.000 1.000 1. 000 1.000 1.000 1.000 1

. 000 1. 000 1.000 1. 000 1. 000 1.000 1. 000 1

. 000 1.000 1

. 000 1. 000 1

. 000 1.000 1.000 1. 000 1.000 1.000 1

. 000 1. 000 1.000 1

. 000 l. 000 1. 000 1.000 1

. 000 1.000 1.000 1

. 000 1

. 000 1. 000 1

. 000 1. 000 1.000 1. 000 1

. 000 1

. 000 1.000 1.000 1

. 000 1.000 1

. 000 1

. 000 1.000

### Propiconazole Dietary Ex posure and Ri sk Assessment DP Numbe r: 0 426495 P

C Code: 122101

9500024001 0 Banana, dried-babyfood 0.200000 3.900 1.00 0 9500111000 0 Coconut, meat 0.100000 1.000 1.000 9500111001 0 Coconut, meat-babyfood 0.100000 1.000 1.000 950 0112000 0 Coconut, dried 0.100000 1.000 1.000 9500113000 0 Coconut, milk 0.100000 1.000 1.000 9500114000 0 Coconut, oil 0.100000 1.000 1.000 9500263000 0 Peanut 0.200000 1.000 1.000 9500264000 0 Peanut, butter 0.200000 1

. 890 1

. 000 9500265000 0 Peanut, oil 0.200000 1.000 1.000 9500275000 0 Peppermint 10.000000 1.000 1.000 9500276000 0 Peppermint, oil 10

. 000000 1 .000 1.000 9500279000 0 Pineapple 4.500000 1.000 1

. 000 9500279001 0 Pineapple

- babyfood 4.5000 00 1

. 000 1. 000 9500280000 0 Pineapple, dried 4.500000 S.000 1.000 9500281000 0 Pineapple, juice 4.500 000 1.700 1.000 9500281001 0 Pineapple, juice-babyfood 4.500000 1.700 1.000 9500283000 0 Plantain 0.200000 1.000 1. 000 9500284000 0 Plantain, dried 0.200000 3

. 900 1.000 9500352000 0 Spearmint 10.0000 00 1.000 1.000 9500353000 0 Spearmint, oil 10.000000 1.000 1.000 9500362000 0 Sugarcane, sugar 0.400000 1.000 1.000 9500362001 0 Sugarcane, sugar-babyfood 0.400000 1

. 000 1. 000 9500363000 0 Sugarcane, molasses 0.400000 1.000 1.000 9500363001 0 Sugarcane, molasses-babyfood 0.400000 1

. 000 1.000 9500372000 0 Tea, dried 4.000000 8.300 1.000 To ace Full comment: To account for ROC in RA highest metabolite ratio 9500373000 0 Tea, instant 4.000000 8.300 1.000 To ace Full comment: To account for ROC in RA highest metabolite ratio 9500398000 0 Watercress

· 6.000000 1

. 000 1. 000



### Page 18 of26

### Propicon azo le Di etary Ex posure and Ri sk Assessment DP Number: 04 26495 PC Code: 122101



## Att achmen t 2. Ac ute Results file.

US EPA DEEM-FCID ACUTE Analysis for PROPICONAZOLE Residue file: 122101 Acute August 2015.R08 Ver. 3.18, 03-08-d NHANES 2003-2008 2-Day Adjustment factor #2 used. file dated: 08-27-20 15 /09 :14:32 Analysis Date: 08-27-2015/09:26 :43 Residue RAC/FF intake summ ed ove r 24 hours Run Comment : ""

Summary calculations--per capita : 95th Percencile 99ch Percentile 99

. 9th Percentile Exposure \' aRfD Exposure t aRfD Exp os ure t aRfD



# ---·------ -------· --- ---- --- -- - --- - - -- - --- --- · 

## -------- Total 

### us Population: 0.078719 26.24 0.160030 53.34 0.376022 125

. 34 All Infants: 0 .111352 37.12 0.188073 62.69 0.357776 119.26 Children 1-2: 0.252947 84.32 0 .433606 144.54 0

. 757159 252 .3 9 Children 3

- 5 : 0.193824 64.61 0. 353977 117

. 99 0. 5098 72 169 .9 6 Children 6-12: 0.106303 35.43 0.192343 64

. 11 0

. 4203 57 140

. 12 Youth 13-19: 0.073978 24.66 0

. 126393 42.13 0.202299 67 .4 3 Adults 20-49: 0.06 1 858 20.62 0.100991 33.66 0

. 185836 61

. 95 Adults 50 -99: 0.0 53388 17.80 0

. 090404 30.13 0

. 157350 52 .4 5 Female 13 -49: 0. 060911 20.30 0.100932 33.64 0.165573 55

. 19


### FOOD ONLY

US EPA DEEM-FCID ACUTE Analysis for PROPICONAZOLE Residue file: 122101 Acut e Food Only.ROS Ver

. 3.18, 03-08-d NHANES 2003-2008 2

- Day Adjustment factor #2 N OT used. file dated: 07- 27 -2015/09 : 18: 28 Ana l ysis Date: 07-27-201 5 /09 : 24 :35 Re sidue RAC/FF int a ke summed over 24 hours Run Comment : " "**=== ==** **===== ==** **=~=== ==** **===== ==** **===== ==** **=========================== ===** **==== ==** **=e== ==** **===** Summary ca l culations--per capita : 95th Percentile 99th Percencile 99

. 9th Percentile Exposure t aRfD E xposu re t aR fD Exp osure t aRfD



## -----·---- --- -- - -- - ------ - -- 

# -------- ·--------- ---- -- -- Tocal 

### us Population: 0. 077760 25.92 0.159032 53.01 0

. 3738 58 124.62 All Infants: 0 .110354 36.78 0.186049 62.02 0.356252 118

. 75 Children 1-2: 0

. 250714 83.57 0.433136 144

. 38 0

. 75819 5 25 2. 73 Children 3-5: 0.193 230 64.41 0.350542 116

. 85 0

. 510102 170

. 03 Children 6-12: 0.105713 35. 24 0 .1 9 1 7 44 63.91 0

. 419511 13 9

. 84 Youth 13-19; 0. 073311 24.44 0.125 193 41.73 0.202048 67.35 Adulcs 20-49: 0

. 0609 1 0 20.30 0

. 1002 0 7 33.40 0.184511 61. 50 Adults 50-99: 0.052357 17.45 0.089768 29

. 92 0.157737 52.58 Female 13- 49: 0.060263 20.0 9 0.100507 33

. 50 0.164521 54

. 84



### P

age 19of 26

### Propiconazo le Dietary Expos ure and Ri s k Asses s me nt DP Number: 042649 5 PC Code: 

### 122 101



### Attachment 3

. C hronic Foo d plu s Wate r Resid ue Inpu t file.

Filename: C:\Users\tmorton\Documents\My Files\DEEM Files \122101 Propiconazole\Petition 4E832l Dill Mustard Watercress Radish \ 122101 Chroni c Avg FT Food and Water.R OS Chemical: Propiconazole RfD(Chronic):

. 1 mg/kg bw/day NOEL(Chronic): O mg/kg bw/day RfD(Acute): .3 mg/kg bw/day NOEL(Acute): O mg/kg bw/day Date created/last modified: 07 -2 7-201S/09 :13: 30 Program ver. 3.16, 03-08-d
EPA Code Crop Grp Commodity Name Def Res (ppm) Ad j.Factors Ill #2
OlOlOSOOOO lAB Beet, garden, roots 0

. 120000 1

. 000 OlOlOSOOOl lAB Beet, garden, roots-babyfood 0 .12 0000 1.000 01010S2000 1A Beet, sugar 0 .12 0000 l

. 000 0101os2001 lA Beet, sugar-babyfood 0

. 120000 l

. 000 01010S3000 lA Beet , sugar, molasses l.S OOOOO 1. 000 01010S3001 lA Beet, sugar, molasses-babyfood l.SOOOOO 1.000 0101078000 lAB Carrot 0 .1 00000 1.000 0101078001 lAB Carrot -bab yfood 0 .1 00000 1.000 0101079000 l AB Carrot, juice 0.100000 1.000 0101314000 lAB Radish , roots O

. OS7000 l

. 000 Full comment: Average residue for parent and metabolites 0101316000 lAB Radish, Oriental, roots O.OS7000 l.000 Full comment: Average residue for parent and metabolites 02000Sl000 2 Beet, garden, tops s.so oooo 1.000 020031SOOO 2 Radish, tops 2.oosooo 1.000 Full com men t: Average residue for parent and metabolites 0200317000 2 Radish, Oriental, tops 2.oosooo 1. 000 Full comment: Average residue for parent and metabolites 030116SOOO 3A Garlic, bulb 0 .2 00000 1.000 030116S001 3A Garlic, bulb-babyfood 0.200000 1

. 000 0301237000 3A Onion

. bulb 0.200000 1.000 0301237001 3A Onion , bu lb- babyfood 0

. 200000 1

. 000 0301238000 3A O nion, bulb, dried 0

. 200000 9

. 000 0301238001 3A Onion, bulb, dried-babyfood 0 .2 00000 9.000 0301338000 3A Shallot, bulb 0.200000 1.000 0302103000 3B Chive, fresh leaves 2 .4 30000 1

. 000 0302198000 3B Lee k 2.4 30000 1

. 000 0302239000 3B 0302338SOO 3B 0401248000 4A 0402076000 4B 0402085000 4 B 040208S001 4B 0402086000 4B 0402087000 4B 04021S2000 4B 0402322000 4B 0402367000 4B OS02063000 SB OS02070000 SB OS02117000 SB OS02194000 SB OS02229000 SB 0502318000 SB 0502389000 SB 0600347000 6 0600349000 6 0600349001 6 06003SOOOO 6 06003S0001 6 0601043000 6A 0601043001 6A 0601349500 6AB 0602031000 6B 0602033000 6B 0602037000 6B Onion, green Shallot, fresh leaves Parsley, leaves Cardoon Celery Celery-babyfood Celery, juice Cel tuce Fennel, Florence Rhubarb Swiss chard Broccoli raab Cabbage, Chinese, bok choy Collards Kale Mustard greens Rape greens Turnip, greens Soybean, seed Soybean, soy milk Soybean, soy m ilk -babyfood or in Soybean, oil Soybean, oil- babyfood Bean, snap, succulent Bean. snap, succulent-babyfood Soybean, vegetable Bean , broad, succulent Bean, cowpea. succulent Bean, lima, succulent 2.430000 2.430000 3.650000 1.010000 1. 010000 1.010000 1.010000 1.010000 1

. 010000 l

. 010000 l

. 010000 4.078000 4.078000 4.078000 4.078000 4

. 078000 4

. 078000 4.078000 0 .26 0000 0

. 260000 0.260000 0

. 260000 0.260000 0

. 700000 0 .7 00000 0.100000 0.100000 0.100000 0.100000



### Page 

### 20 of26 1. 000 1. 000 l.000 1

. 000 1. 000 1

. 000 l

. 000 1.000 l.000 1.000 1.000 l. 000 1.000 1.000 1. 000 1 .000 1.000 1

. 000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1 .000 1

. 000 l. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1

. 000 1.000 1 .000 l

. 000
1.000
1.000 1

. 000
1.000
l.000 l.000 1.000 1.000 1. 000 l

. 000 l.000 1. 000 1.000 l.000 1.000 1.000 1.000 l

. 000 1.000 1

. 000 1.000 1.000 1

. 000 l

. 000 1. 000 1.000 l.000 1.000 1

. 000 l

. 000 l.000 l

. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1

. 000 1.000 1.000 Comment

Averag Ave rag

Ave rag Ave rag

### P rop ico nazo le PC Cod e: 122 101

0603030000 6C 0603032000 6C 0603034000 6C 0603035000 6C 0603036000 6C 060303SOOO 6C 0603039000 6C 0603040000 6C 0603041000 6C 0603042000 6C 060309SOOO 6C 060309S001 6C 0603099000 6C 06031S2000 6C 06031S2001 6C 060334SOOO 6C 060334S001 6C OS01374000 SA 0801375000 SA OS01375001 SA OS01376000 SA OS01376001 SA OS01377000 SA 0801377001 SA OS0137SOOO SA OS0137S001 SA OS01379000 SA OS013SOOOO SA 1001106000 lOA 1001107000 lOA lOOllOSOOO lOA 1001240000 lOA 1001241000 lOA 1001241001 lOA 1001242000 lOA 1001369000 lOA 10013 70000 lOA 1002197000 lOB 1002199000 lOB 1002200000 lO B 1002200001 lOB 1002201000 lOB 1002206000 lOB 1002207000 lOB 1002207001 lO B 1003180000 lOC 10031Sl000 lOC 1003307000 lOC 1201090000 12A 1201090001 12 A 1201091000 12A 1201091001 12A 1202012000 12B 1202012001 12B 1202013000 12B 1202014000 12B 1202014001 12B 1202230000 12B 1202260000 12B 1202 26 0001 12B 1202261000 12B 1202261001 12B 1202262000 12B 1202262001 12B 1203285000 12C 12032S5001 12C 12032S6000 12C 12032S6001 12C 12032S7000 12C 120 32S 700 1 12C 

### Di e tary Exp os ure and Ri s k A sses sme nt

Bean, black, seed Bean, broad, seed Bean, cowpea, seed Bean, great northern, seed Bean, kidney, seed Bean, lima, seed Bean, mung, seed Bean, navy, seed Bean, pink, seed Bean, pinto, s eed Chickpea, seed Chickpea, seed

- babyfood Chickpea, flour Guar. seed Guar, seed-babyfood Soybean, flour Soybean, flour

- babyfood Tomatillo Tomato Tomato

- babyfood Tomato, paste Tomato, paste-babyfood Tomato, puree Tomato, puree
- babyfood Tomato, dried Tomato, dried

- babyfood Tomato, juice Tomato, Tree Citron Citrus hybrids Citrus, oil Orange Orange, juice Orange, juice-babyfood Orange, peel Tangerine Tangerine. juice Kumquat Lemon Lemon, juice Lemon, juice-bab yfood Lemon, peel Lime Lime, juice Lime, juice

- babyfood G

r apefruit Grapefruit, juice Pummelo Cherry Cherry-babyfood Cherry, Juice Cherry. juice-babyfood Apricot Apricot

- babyfood Apricot, dried Apricot, juice Apricot, juice-babyfood Nectarine Peach Peach-babyfood Peach. dried Peach. dried-babyfood Peach, juice Peach, juice-babyfood Plum Plum

- babyfood Plum, prune, fresh Plum, prune, fresh-babyfood Plum, prune, dried Plum, prune. dried-babyfood 0.400000 0.400000 0 .4 00000 0.400000 0.400000 0.400000 0.400000 0.400000 0.400000 0. 400 000 0.400000 0.400000 0.400000 0.400000 0 .400000 0.260000 0.260000 0.791000 0.791000 0.791000 0.791000 0.791000 0.791000 0.791000 0.791000 0.791000 0.791000 0.791000 2.340000 2.340000 1000.

2.340000 2.340000 2.340000 2.340000 2. 340000 2.340000 2.340000 1.790000 1.790000 1

. 790000 1.790000 2.340000 2.340000 2.340000 l.lSOOOO l.lSOOOO l.lSOOOO l.OSOOOO 1.080000 l.OSOOOO l.OSOOOO 0.9S9000 0.9S9000 0.9S9000 0.9S9000 0.9S9000 0.9S9000 0.9S9000 0.9S9000 0.9S9000 0.9S9000 0.9S9000 0.9S9000 0.192000 0.192000 0.192000 0.192000 0.192000 0.192000



### Page 2 I of2 6 l. 000 l.000 1.000 1

. 000 1.000 1

. 000 1.000 1.000 1.000 1.000 l. 000 l.000 l.000 1.000 1.000 1

. 000 1.000 1

. 000 1.000 1.000 5

. 400 5 .400 3

. 300 3.300 14.300 14

. 300

l

. 500 l. 000 1.000 1

. 000 1

. 000 1 .000 1

. 000 1 .000 1.000 1.000 1.000 l. 000 1.000 l. 000 1.000 1.000 1

. 000 l

. 000 1.000 1.000 1.000 l. 000 1.000 l. 000 1.500 1

. 500 l. 000 1.000 6

. 000 1.000 1.000 1.000 1.000 1.000 7.000 7.000 1.000 1.000 1.000 1.000 1.000 l. 000 5.000 5

. 000 

### DP Numb er : D4 26 495

l.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1 .00 0 l. 000 1.000 l. 000 1.000 1.000 1.000 1.000 l.000 1.000 1 .000 1.000 l.000 1.000 1.000 1.000 1.000 1

. 000 1.000 l.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 l. 000 1.000 1.000 1.000 1.000 l. 000 1.000 1

. 000 1.000 1.000 1 .000 1.000 l.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1

. 000 1.000 1.000 1.000 1.000 1.000Propi co nazo l e PC Co de: 1 22 101

1203288000 12C 1203288001 12C 1301055000 13A 1301056000 l3A 1301056001 l3A 1301058000 l3 A 1301208000 l3A 1301320000 13A 1301320001 13 A 1301321000 13 A 1301321001 13A 1302057000 l3B 1302057001 13 B 1302136000 13B 1302137000 13B 1302149000 13 B 1302174000 13 8 1302191000 13B 1307130000 13G 1307130001 13G 1307131000 13G 1307132000 13G 1307132001 13G 1307359000 13G 1307359001 13G 1307360000 l3G 1307360001 13G 1400003000 14 1400003001 14 140000 4000 14 1400004001 14 1400059000 14 1400068000 14 1400081000 14 1400092000 14 1400155000 14 1400156000 14 1400185000 l4 1400213000 14 1400269000 14 1400278000 14 1400282000 14 1400391000 14 1500025000 15 1500025001 15 1500026000 15 1500026001 15 1 5000270 00 15 1500120000 15 1500120001 15 1500121000 15 1 500121001 15 1500122000 15 1500123000 15 1500123001 15 1500124000 15 1500124001 15 1500125000 15 1500125001 15 1500126000 15 1500127000 15 1500127001 15 1500231000 15 1500232000 15 1500232001 15 1500233000 15 1500233001 15 1500323000 15 1500323001 15 150032 4000 15 Di etary Exposure and !Usk Assessme nt

Plum, prune, juice Plum, prune, juice- babyfood Blackberry Blackberry, j uice Blackberry, juic e-babyfood Boysenberry Lo ga nberry Raspberry Raspberry-babyfood Raspberry, juice Raspberry, juice-babyfood Blueberry Blueberry-babyfood Currant Currant, dr ied Elderberry Gooseberry Huckleberry Cranberry Cranberry-babyfood Cranberry, dried Cranberry, jui ce Cranberry, juice-babyfood Strawberry Strawberry-babyfood Strawberry, juice Strawberry, juice-babyfood Almond Almond-babyfood Almond, oil Almond, o il -ba byf ood Brazil nut Butternut Cas h ew Chestnut Hazelnut Hazelnut, oil Hickory nut Macadamia nut Pecan Pin e nut Pistachio Walnu t Ba rle y, pearled barley Barley, pea rle d barley-babyfood Barley, flour Barley, flour-babyfood Barley, bran Corn, field. flour Corn, fi eld

. flour-babyfood Corn, field, meal Corn, field, meal

- babyfood Corn, fi eld , bran Corn , field, starch Corn, fi eld, starch

- babyfood Corn, field, syrup Corn, field, syrup-babyfood Corn, field, oil Corn. field, oil-babyfood Co rn , pop Corn, sweet Corn, swee t -babyfood Oat, bran Oat, flo ur Oat, flo ur -babyfood Oat

. groats / rolled oats Oat, groats/ro ll ed oats

- babyfood Rice, white Rice, white -ba byf ood Rice, brown

Page 22 of26 0 .192000 0.192000 0.360000 0.360000 0 .36 0000 0 .36 0000 0 .3 60000 0 .36 0000 0

. 360000 0 .36 0000 0 .36 0000 0 .35 0000 0

. 350000 0 .36 0000 0

. 360000 0

. 360000 0.360000 0

. 360000 0 .32 0000 0 .32 0000 0. 32 0000 0 .3 20000 0

. 320000 0.350000 0 .350000 0 .35 0000 0

. 350000 0.038000 0

. 038000 0 .038 000 0.038000 0.100000 0

. 100000 0.100000 0. 1 00000 0

. 100000 0.100000 0 .1 00000 0 .1 00000 0

. 100000 0.100000 0.100000 0.100000 3.000000 3

. 000000 3

. 000000 3.000000 6

. 000000 0.036000 0 .036 000 0 .036 000 0 .0 36000 0.036000 0.036000 0 .0 36000 0.036000 0 .036 000 0 .0 36000 0 .036 000 0

. 036000 0

. 100000 0 .10 0000 6

. 000000 3 .0 00000 3 .00 0000 3.000000 3.000000 1.490000 l. 49 0000 1 .4 90000 1.400 l. 4 00 l.000 1.000 l.000 1

. 000 l. 000 l. 000 l. 000 l. 000 l

. 000 l .0 00 1 .0 00 1 .00 0 1.000 1 .000 1

. 000 1.000 1

. 000 1

. 000 1.000 1

. 100 1.100 1.000 1

. 000 1.000 l

. 000 1.000 1.000 1

. 000 l.000 1.000 1.000 l.000 l. 000 1 .0 00 l. 000 l.000 1.000 l. 000 l. 000 l.000 1 .0 00 1 .0 00 1.000 l. 000 l. 000 l.000 1 .0 00 l.000 1.000 1 .0 00 1.000 1.000 1

. 000 1.500 1.500 l.000 1.000 1 .0 00 1 .000 1 .000 1

. 000 l. 000 1 .0 00 1

. 000 l. 000 l.000 l .0 00 l

. 000 DP N umb e r : D426495

l. 000 1

. 000 1. 000 l

. 000 1

. 000 1.000 1.000 1.000 1

. 000 l

. 000 1.000 l. 000 1.000 1

. 000 1

. 000 l. 000 1

. 000 1

. 000 1

. 000 l

. 000 l.000 l. 000 l. 000 1

. 000 1 .0 00 l.000 1.000 1

. 000 1

. 000 1.000 1

. 000 1.000 1.000 1. 000 1.000 1

. 000 1.000 l.000 1

. 000 1.000 1. 000 l.000 l. 000 1.000 1

. 000 l. 000 l.000 1.000 1

. 000 l. 000 1

. 000 l. 000 l

. 000 l

. 000 1. 000 l

. 000 1.000 1. 000 1.000 1

. 000 1

. 000 1. 000 1

. 000 l. 000 l.000 1.000 1

. 000 1.0 00 1

. 000 1.000Propi co naz ol e Dietary Ex po s ure and Ri s k A ssess ment DP Number : D4 26495 PC Co de : 12 2 101

150032 4001 1 5 Rice, brown-ba byfood 1.490000 1.000 1. 000 1500325000 15 Rice, flour 1

. 4 90000 1.000 1. 000 1500325001 15 Rice, flour -b aby food 1.490000 1.000 1.000 1500326000 15 Rice, bran 15

. 000000 1.000 1. 000 1500326001 15 Rice , bran-babyfood 15

. 000000 1.000 1. 000 1500328000 15 Rye, grain 0.300000 1.000 1.000 1500329000 15 Rye, flour 0

. 300000 1.000 1. 000 1500344000 15 Sorghum, grain 1.270000 1.000 1. 000 1500345000 15 Sorghum, syrup 1

. 270000 1.000 1. 000 150038 1 000 15 Triticale, fl ou r 0.043000 1.000 1.000 1500381001 15 Triticale, flour

- babyfood 0 .04 3000 1.000 1. 000 150040 1 000 15 Wheat, grain 0

. 043000 1.000 1.000 1500401001 15 Wheat, grain -babyfood 0

. 043000 1.000 1.000 1500402000 15 Whea t , flour 0

. 043000 1 .000 1. 000 1500402001 15 Wheat, flou r
- babyfood 0

. 043000 1.000 1

. 000 1500403000 15 Wheat, germ 0

. 043000 1.000 1 .000 1 500404000 15 Wheat , bran 0

. 600000 1.000 1. 000 1500405000 15 Wild rice 0 .5 00000 1.000 1. 000 1901118000 19A Cilantro , leaves 13

. 000000 1.000 1.000 1901118001 19A Cilantro, leaves-babyfood 13

. 000000 1.000 1. 000 1901144000 19A Dill weed 23

. 118000 1.000 1. 000 dried Full comment: dr ied dillweed 1901249000 19A Parsley , dried leaves 35

. 000000 1.000 1. 000 1901249001 19A Parsley, dried leaves -baby food 35.000000 1.000 1.000 1902143000 19 B Dill, seed 2

. 447000 1. 000 1. 000 2001163000 20A Fl ax seed, oil 0.081000 0.200 1.000 2001319000 20A Rapeseed, oil 0.081000 0.200 1. 000 2001319001 20A Rapeseed, oil-babyfood 0

. 081000 0.200 1.000 2001336000 20A Sesame, seed 0

. 081000 1

. 000 1. 000 200133 6001 20A Sesame, seed-babyfoo d 0

. 081000 1.000 1.000 2001337000 20A Sesame, oil 0

. 081000 0.200 1. 000 2001337001 20A Sesame, oil -babyfood 0

. 081000 0.200 1. 000 2003114001 20C Coconut, oil-babyfood 0.100000 1.000 1.000 2100228000 21 Mushroom 0

. 100000 1

. 000 1.000 3100044000 31 Beef, meat 0

. 050000 1

. 000 1. 000 3100044001 31 Beef, meat-babyfood 0

. 050000 1.000 1. 000 3100045000 31 Beef. meat, dried 0

. 050000 1. 920 1.000 3100046000 31 Beef, meat byproducts 0

. 050000 1.000 1

. 000 3100046001 31 Beef, meat byproducts

- babyfood 0

. 050000 1.000 1.000 3100047000 31 Beef, fat 0

. 050000 1

. 000 1.000 31000 47 001 31 Beef , fat

- babyfood 0

. 050000 1. 000 1.000 3100048000 31 Beef, kidney 2

. 000000 1.000 1.000 31000 49 000 31 Beef, liver 2

. 000000 1. 000 1. 000 3100049001 31 Beef, liver

- babyfood 2

. 000000 1.000 1.000 3200169000 32 Goat. meat 0.050000 1. 000 1.000 3200170000 32 Goat, meat b yproducts 0.050000 1.000 1. 000 3200171000 32 Goat, fat 0

. 050000 1.000 1. 000 3200172000 32 Goat, kidney 2

. 000000 1.000 1.000 3200173000 32 Go at, liver 2.000000 1. 000 1. 000 3300189000 33 Hors e
. meat 0

. 050000 1 .00 0 1.000 3400294000 34 Pork, kidney 0 .2 00000 1.000 1.000 3400295000 34 Pork , liver 0

. 200000 1.000 1. 000 3500339000 35 Sheep, meat 0

. 050000 1.000 1

. 000 3500339001 35 Sheep, meat-babyfood 0 .050000 1.000 1. 000 3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.000 3500341000 35 Sheep. fat 0

. 050000 1.00 0 1. 000 3500341001 35 Sheep , fat- babyf ood 0

. 050000 1.000 1

. 000 3500342000 35 Sheep, k idne y 2.000000 1. 000 1. 000 3500343000 35 Sheep. liver 2

. 000000 1 .00 0 1.000 3600222000 36 M ilk, fa t 0

. 050000 1.000 1.000 3600222001 36 Milk, fat

- baby food/infant formu 0

. 050000 1.000 1. 000 3600223000 36 Milk, nonfat solids 0.050000 1.000 1.000 3600223001 36 Milk, nonfat solids -baby food/in 0

. 050000 1

. 000 1

. 000 360022 4000 36 Milk, water 0.050000 1. 000 1.000 3600224001 36 M ilk, water-babyfood/infant form 0

. 050000 1.000 1. 000 3600225001 36 M ilk, sugar (lactose)-baby food / 0.050000 1

. 000 1.000 8601000000 86A Water, d irect, all sources 0

. 035100 1

. 000 1.000 8602000000 86B water, indirect , all sources 0

. 035100 1. 000 1.000 9500020000 0 Avocado 10.000000 1.000 1

. 000 9500023000 0 Banana 0

. 200000 1.000 1

. 000

Page 23 of26

### Propiconazo le D i e tary Ex po s ure and Ri s k A ss es s me nt DP Number: 04264 95 PC C ode: 122 101

9500023001 0 Banana

- b aby food 0.200000 1.000 1.000 9500024000 0 Banana, dri ed 0.200000 3.900 1.000 9500024001 0 Banana, dried-babyfood 0.200000 3.900 1.000 9500111000 0 Coconut, meat 0.100000 1.000 1.000 9500111001 0 Coconu t, meat-b abyfood 0 .100000 1.000 1

. 000 9500112000 0 Coconut, dried 0.100000 1 .000 1. 000 9500113000 0 Coconut, milk 0.100000 1.000 1.000 950011 4 000 0 Coconut, oil 0.100000 1

. 000 1

. 000 95002 6300 0 0 Peanut 0.200000 1

. 000 1.000 95002 64000 0 Peanut, b utter 0

. 200000 l. 890 1

. 000 9500265000 0 Peanut, oil 0.200000 1.000 1.000 9500275000 0 Peppermint 10.000000 1

. 000 1.000 9500 2760 00 0 Peppermint, oi l 10.000000 l .000 l.000 9500279000 0 Pineapple l. 110000 1

. 000 1.000 9500279001 0 Pineapp l e-babyfood 1.110000 1.000 1.000 9500280000 0 Pineapple, dried 1.110000 5

. 000 1 .00 0 9500281000 0 Pineapple, j u i ce 1

. 110000 l.000 1.000 9500281001 0 Pineapple, jui ce
- babyfood 1.110000 1.000 1 .000 9500283000 0 Plantai n 0.200000 1 .000 1.000 950028 4 000 0 Plantain, dried 0.200000 3.900 1.000 9500352000 0 Spearmint 10.000000 1.000 1

. 000 9500353000 0 Spearmint, oil 10.000000 1.000 l.000 9500362000 0 Sugarcane, suga r 0.120000 1.000 1

. 000 95003 62001 0 Sugarcane, sugar-babyfood 0.120000 l

. 000 l. 000 9500363000 0 Sugarcane, molasses 0.120000 1 .000 1. 000 9500363001 0 Sugarcane, molasses-babyfood 0.120000 1.000 1.000 9500372000 0 Tea , dried 4.000000 8.300 1.000 To ace Full comment: To account for metabolite ROC in RA 9500373000 0 Tea, instant 4.000000 8.300 1.000 To ace Full comment: To account for metabolite ROC in RA 9500398000 0 Waterc r ess 1.698000 1

. 000 1.000



### P

age 24 of26

### Propiconazole Dietary Ex po s ure and Ri sk Assessment DP Numbe r : 0426495 P

C Co de: 122 101



### Attachment 4. C hronic R esu lt s fil e.

US EPA Ver. 3.16, 03-08-d DEEM

- FCID Chronic analysis for PROPICONAZOLE NHANES 2003-2008 2-day Residue file name: C:\Users\tmorton\Documents\My Files\DEEM Files\122101 Propiconazole\Petition 4E8321 Di ll Mustard Watercress Radish\122101 Chronic Avg FT Food and Water.ROS Adjustment factor #2 used

. Analysis Date 08-27-2015/09 : 22:19 Residue file dated: 08-27-2015/09:20:33 Reference dose ( RfD, Chronic ) 

### = .l mg/kg bw / day

Population

Subgroup
Total US Population Hispanic Non

- Hisp

- White Non-Hisp-Black Non-Hisp-Ocher Nursing Infants Non-Nursing Infancs Female 13+ PREG Children 1-6 Children 7- 12 Male 13-19 Female lJ -1 9/NP Male 20+ Female 20+/NP Seniors SS+ All Infants Female 13-50 Children 1- 2 Children 3-5 Children 6-12 Youth 13-19 Adulcs 20

- 49 Adults 50 -9 9 Female 13

- 49 Total exposure by population subgroup

Total Exposure mg/kg body wt /d ay 0

. 008012 0.010493 0.00737 4 0.008302 0.009390 0.006959 0.013004 0 .0086 93 0

. 020611 0.009661 0.006923 0

. 005969 0.006876 0.006159 0.006156 0.011138 0.006206 0.024493 0.019799 0.010409 0.006435 0.006739 0.006270 0.006176



### Page 25 of26 Percenc of Rfd
8.0t 10.5\

7 .4\ 8 .3\ 9 .4\ 7.0t 13.0\ 8

. 7\ 20.6\

9

. 7t 6.9\ 6.0\ 6.9\ 6.2\ 6.2t 11.1\

6.2\ 24.5\ 19 .8\ 10.4\

6.4\ 6.7\ 6.3\ 6.2\

### Propiconazol e Dietary Ex posure and Ri s k Assessment DP Numb er: D4 26495 PC Code: 1 2210 1



### Food Onl y

us EPA Ver

. 3.16, 03-08-d DEEM-FCID Chronic analysis for PROPICONAZ OLE NHANES 2003

- 2008 2-day Residue file name: C:\Users\tmorton\Documents\M y Files\DEE M Files\122101 Propiconazole \ Petition 4E8321 Dill Mustard Watercress Radish \ 122101 Chronic Avg FT Food Only.ROS Adjustment factor #2 used. Analysis Date 08-27 -2 015/09:22 : 42 Residue file dated: 08-27-2015/09:21 : 11 Reference dose ( RfD, Chronic ) = .1 mg/kg bw/day

======== === =c=== == ================================================= === === = = == == Total expos ure by population subgroup

Population

Subgroup
Total US Popu lation Hispanic Non-Hisp-White Non-H isp -Bl ack Non-Hisp-Other Nursing Infants Non-Nursing Infants Fema le 13+ PREG Children 1-6 Children 7-12 Male 13

- 19 Female 13-19/NP Male 20+ Female 20+ /NP Seniors 55+ All Infants Fema le 13-50 Children 1- 2 Children 3-5 Childre n 6-12 Youth 13-19 Adults 20-49 Adults 50

- 99 Female 13-49 Total Exposure
mg / kg body wt / day
0

. 007277 0

. 009791 0

. 006618 0

. 007695 0

. 008543 0.006294 0

. 010560 0

. 008001 0.019669 0

. 009048 0

. 006417 0

. 005402 0.006191 0

. 005387 0

. 005445 0

. 009243 0

. 005475 0

. 023432 0.018906 0

. 009765 0

. 005899 0.006006 0

. 005545 0.005446



### Page 26 of26 Percent of Rfd
7.3% 9.8\ 6 .6' 7

. 7\ 8.5\ 6.H 10.6'

8.0\ 19. 7\

9.0t 6 .4\ 5 .4\ 6.2\ 5 .4\ 5 .4\ 9.2\ 5.5\ 23 .4\ 18.9\

9.8\ 5

. 9\ 6.0\ 5.5\ 5 .4\