<PAGE>   1
                                                                    EXHIBIT 10.4

                            BUSINESS LOAN AGREEMENT

                                      dated

                                October 28, 1999

                                     among

                            GENOMIC SOLUTIONS, INC.

                                              "Parent"
                                       and

                            GENOMIC SOLUTIONS, LTD.
                            GENOMIC SOLUTIONS, K.K.

                                           "Subsidiaries"
                                      and

                        WHITE PINES LIMITED PARTNERSHIP I
                              PACIFIC CAPITAL, L.P.
                     CHASE VENTURE CAPITAL ASSOCIATES, L.P.
                           AMERICAN HEALTHCARE FUND II
                                 IAN R. N. BUND
                       YOCUM CONSULTING ASSOCIATES, INC.
                     VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C
                              J. MATTHEW MACKOWSKI
                                ROBERT G. SHEPLER
                                JOHN J. MACKOWSKI
                            GROVE INVESTMENT PARTNERS
             RONALD G. KALISH LIVING TRUST U/A/D SEPTEMBER 9, 1997
            McDONALD INVESTMENTS INC. CUSTODIAN FBO DANIEL J. BOYLE
                         IRA ROLLOVER ACCOUNT #85314893
                   KANTNER AND ASSOCIATES PROFIT SHARING PLAN
                              U/A/D JANUARY 1, 1991
                              MICHAEL G. WILLIAMS
                                LAWRENCE J. KENT
                              JEFFREY S. WILLIAMS
                                 KEVIN A. AUTON
                              ANDREW A. JAKIMCIUS
                                MICHAEL P. KUREK
                              STEVEN J. RICHVALSKY

                                               "Lenders"

<PAGE>   2




                                TABLE OF CONTENTS

                                                                         Page
                                                                         ----
1. LOAN AGREEMENT                                                          2
   ----------------
   (a) Present Loan                                                        2
   (b) Conditions - Present Loan                                           3
   (c) Future Loan                                                         3
   (d) Additional Loan to Satisfy
       Preemptive Rights                                                   4

2. EXECUTION OF NOTES                                                      4
   ------------------

3. EQUITY - INITIAL ISSUANCE                                               4
   -------------------------
   (a) Warrants - Noncancellable                                           4
   (b) Warrants - Cancellable Upon $5.00
       Liquidity Event                                                     5
   (c) Warrants - Cancellable Upon Premium
       Liquidity Event                                                     5

4. INTENTIONALLY OMITTED                                                   6

5. SECURITY, ASSURANCES AND INSURANCE                                      6
   ----------------------------------
   (a) Collateral                                                          6
   (b) Pledge                                                              7
   (c) Subsidiaries' Security                                              7
   (d) Insurance - Property                                                7
   (e) Insurance - Life                                                    7
   (f) Further Assurances                                                  8

6. CONDITIONS OF LOAN                                                      8
   ------------------
   (a) Approval of Lender's Counsel                                        8
   (b) Representations and warranties                                      8
   (c) Compliance                                                          8
   (d) Evidence of Corporate Action                                        8
   (e) Opinion of Borrower's Counsel                                       8
   (f) SBA Forms                                                           9
   (g) Certificates                                                        9
   (h) Bylaws                                                              9
   (i) Insurance                                                           9
   (j) Due Diligence                                                       9
   (k) intentionally ommitted                                              9
   (1) Subordination                                                       9
   (m) Receipt of Executed Documents                                       9
   (n) Consents                                                           10

7. REPRESENTATIONS AND WARRANTIES                                         10
   ------------------------------
   (a) Organization and Standing; Charter
       and Bylaws                                                         11
   (b) Capitalization                                                     11

                                      -i-

<PAGE>   3

                                                                         Page
                                                                         ----
   (c) Corporate Power; Authorization                                     12
   (d) Validity of Securities                                             13
   (e) Consents and Waivers                                               13
   (f) Litigation                                                         13
   (g) Shareholder Lists and Agreements;
       Officers and Directors                                             13
   (h) Subsidiaries                                                       14
   (i) Financial Statements                                               14
   (j) Absence of Undisclosed Liabilities                                 15
   (k) Absence of Certain Developments                                    15
   (1) Title to Assets                                                    15
   (m) Real Property                                                      16
   (n) Tax Matters                                                        16
   (o) Contracts and Commitments                                          16
   (p) Proprietary Rights; Employee Restriction                           17
   (q) Effect of Transactions                                             18
   (r) Insurance                                                          18
   (s) Securities Act Registration                                        18
   (t) Business; Compliance with Laws                                     18
   (u) Books and Records                                                  18
   (v) Employee Benefit Plans                                             19
   (w) Small Business Matters                                             19
   (x) Information Suppied to the Lenders                                 19
   (y) Employees                                                          20
   (z) Business Operations                                                20
   (aa)Collectibility of Accounts Receivable                              20
   (bb)Inventory                                                          20

8. AFFIRMATIVE COVENANTS                                                  20
   ---------------------
   (a) Financial Statements                                               20
   (b) Payment of Taxes                                                   21
   (c) Insurance                                                          21
   (d) Notice of Adverse Events                                           22
   (e) Maintenance                                                        22
   (f) Board of Directors                                                 22
   (g) Environmental Compliance/Notices/Indemnity                         22
   (h) Maintain Corporate Existence and
       Due Qualification                                                  23
   (i) Compliance With All Laws                                           23
   (j) Information From Senior Lender                                     23
   (k) Reports                                                            23
   (1) Compliance Certificate                                             23
   (m) Use of Proceeds                                                    23
   (n) Compliance with ERISA                                              24
   (o) Patent Applications                                                24
   (p) Disclosure                                                         24
   (q) Reinstatement of Security Interests                                24

9. NEGATIVE COVENANTS                                                     25
   ------------------
   (a) Financial Covenants                                                25

                                      -ii-

<PAGE>   4
                                                                         Page
                                                                         ----
   (b) Liens and Indebtedness                                             25
   (c) Dividends, Distributions; Capital Structure                        26
   (d) Stock                                                              26
   (e) Leases                                                             26
   (f) Environmental                                                      26
   (g) Transations with Insiders or Related
       Companies                                                          26
   (h) Nature of Business                                                 27
   (i) Change In Management                                               27

10.EVENTS OF DEFAULT                                                      27
   -----------------
   (a) Failure to Pay Amounts Due                                         27
   (b) Misrepresentation; False Financial
       Information                                                        27
   (c) Noncompliance with Lender Agreements                               27
   (d) Other Creditor Events                                              27
   (e) Judgments; Attachments; Tax Liens                                  27
   (f) Indictment                                                         28
   (g) Business Suspension, Bankruptcy                                    28
   (h) Material Adverse Change                                            28
   (i) Hazardous Material                                                 28
   (j) Use Of Proceeds                                                    28

11.REMEDIES ON DEFAULT                                                    29
   -------------------
   (a) Acceleration                                                       29
   (b) Remedies Cumulative                                                29
   (c) No Waiver                                                          29

12.OTHER CONSIDERATION TO LENDERS                                         29
   ------------------------------
   (a) Closing Fee                                                        29
   (b) Expenses                                                           29
   (c) Repurchase of Securities Upon
       Declination of Sale of Borrower                                    30
   (d) Exchange of Securities                                             30

13.REPRESENTATIONS AND WARRANTIES OF LENDER                               31
   ----------------------------------------
   (a) Investment                                                         31
   (b) Transfers                                                          31
   (c) Accredited Investor                                                31
   (d) Restrictive Legend                                                 32
   (e) Sophistication                                                     32
   (f) Legal Investment                                                   32

14.MISCELLANEOUS                                                          32
   -------------
   (a) Rights Cumulative; Waivers                                         32
   (b) Notices                                                            32
   (c) Reimbursement For Expenses                                         34
   (d) Binding Effect                                                     34
   (e) Generally Accepted Accounting Principles                           34
   (f) No Partnership Or Joint Venture Established                        35

                                     -iii-

<PAGE>   5


                                                                         Page
                                                                         ----
   (g) Governing Law; Jurisdiction                                        35
   (h) Further Action                                                     35
   (i) Writings Constitute Entire Agreement;
       Modifications Only In Writing                                      35
   (j) Survival Of Terms, Representations
       and Warranties                                                     36
   (k) Jury Trial Waivers                                                 36
   (1) Indemnification                                                    36
   (m) Lender's Assignment                                                36
   (n) Brokers                                                            37
   (o) Counsel for Certain Lenders                                        37

15.CONSTRUCTION AND INTERPRETATION                                        37
   -------------------------------

EXHIBITS
--------
<TABLE>
<CAPTION>

Exhibit                 Description of                              First Referred to
  No.                       Exhibit                                     in Section
  ---                       -------                                     ----------
<S>                <C>                                                     <C>
  A                Promissory Note                                          2
  B-1              Warrants (Noncancellable)                                3(a)
  B-2              Warrants (Cancellable @ $5.00)                           3(b)
  B-3              Warrants (Cancellable > $5.00)                           3(c)
  C                Security Agreement                                       5(a)
  D                Subordination Agreement                                  5(a)
  E                Opinion of Borrower's Counsel                            6(e)
  F                Amendment to Registration
                   Rights Agreement                                         6(m)(iii)
  G                Amendment to Shareholders Agreement                      6(m)(iv)
  H                Assignment and Pledge Agreement                          5(b)

SCHEDULES
---------
<CAPTION>

Schedule
   No.               Description of Schedule
   ---               -----------------------
<S>                  <C>
   7(b)              Agreements Relating to Capital Stock
   7(f)              Litigation
   7(g)              Shareholders, Officers and Directors
   7(h)              Subsidiaries
   7(i)              Financial Statements
   7(k)              Recent Developments
   7(l)              Liens and Encumbrances
   7(o)              Contracts
   7(p)              Intellectual Property Rights
   7(x)              Business Plan
   7(z)              Business Names; Addresses

</TABLE>

                                      -iv-
<PAGE>   6


                            BUSINESS LOAN AGREEMENT

     Agreement made and entered into this 28th day of October, 1999, by and
among Genomic Solutions, Inc., a Delaware corporation, 4355 Varsity Drive, Suite
E, Ann Arbor, Michigan 48108 (hereinafter referred to as "Parent"), Genomic
Solutions, Ltd., a United Kingdom corporation, Unit 3, Forge Close, Little End
Road, Eaton Socon, St. Neots, Cambridgshire, England PE193TP (sometimes
hereinafter referred to as "Genomic UK") , Genomic Solutions, K.K., a Japanese
corporation, Gotanda Chuo Bldg. 2F, 3-5, Higashigotanda 2-chome, Shinagawa-ku,
Tokyo 141-0022, Japan (sometimes hereinafter referred to as "Genomic Japan")
(Genomic UK and Genomic Japan each sometimes hereinafter being referred to as a
"Subsidiary" and sometimes hereinafter collectively referred to as the
"Subsidiaries", and each of Parent, Genomic UK and Genomic Japan sometimes
hereinafter referred to as "Borrower", a "Borrower" or the "Borrower" and
collectively sometimes referred to as the "Borrowers"), White Pines Limited
Partnership I, a Michigan limited partnership, 2401 Plymouth Road, Suite B, Ann
Arbor, Michigan 48105 (hereinafter referred to as "WPLP"), Pacific Capital,
L.P., a Delaware limited partnership, 2401 Plymouth Road, Suite B, Ann Arbor,
Michigan 48105 (hereinafter referred to as "Pacific"), Chase Venture Capital
Associates, L.P., a California limited partnership, 380 Madison Avenue, 12th
Floor, New York, New York 10017 (hereinfter referred to as "Chase"), American
Healthcare Fund II, a Delaware limited partnership, 4430 Arapahoe Avenue, Suite
220, Boulder, Colorado 80303 (hereinafter referred to as "American"), Ian R. N.
Bund, 2401 Plymouth Road, Suite B, Ann Arbor, Michigan 48105 (hereinafter
referred to as "Bund"), Yocum Consulting Associates, Inc., an Ohio corporation,
4622 Wyndwood Drive, Toledo, Ohio 43623 (hereinafter referred to as "Yocum"),
Volunteer Healthcare Associates, L.L.C., a Tennessee limited liability company,
6 Cadillac Drive, Suite 310, Brentwood, Tennessee 37027 (hereinafter referred to
as "Volunteer"), J. Matthew Mackowski, 275 Post Street, Suite 600, San
Francisco, California 94108 (hereinafter referred to as "Mackowski-CA"), Robert
G. Shepler, 275 Post Street, Suite 600, San Francisco, California 94108
(hereinafter referred to as "Shepler"), John J. Mackowski, 1506 Birkdale Lane,
Ponte Verde Beach, Florida 32082 (hereinafter referred to as "Mackowski-FL"),
Grove Investment Partners, an Illinois partnership, 336 Essex Road, Kenilworth,
Illinois 60043 (hereinafter referred to as "Grove") Ronald G. Kalish Living
Trust u/a/d September 9, 1997, 445 Grand Bay Drive, #1009, Key Biscayne, Florida
33149 (hereinafter referred to as "Kalish"), McDonald Investments Inc. Custodian
FBO Daniel J. Boyle IRA Rollover Account #85314893, 2550 Som Center Road, Suite
300, Willoughby Hills, Ohio 44094 (hereinafter referred to as "Boyle"), Kantner
and Associates Profit Sharing Plan u/a/d January 1, 1991, 661 Airport Blvd.,
Suite 2A, Ann Arbor, Michigan 48108 (hereinafter referred to as "Kantner"),
Michael G. Williams, 18000 Cavanaugh Lake Road, Chelsea, Michigan 48118
(hereinafter referred to as "Williams"), Lawrence J. Kent, 404 E. Lancaster
Ave., Wayne, Pennsylvania 19087 (hereinafter referred



                                       1
<PAGE>   7





to as "Kent") , Jeffrey S. Williams, 7049 Suncrest Drive, Saline, Michigan 48176
(hereinafter referred to as "JWilliams"), Kevin A. Auton, 42 Croftfield Road,
Godmanchester, Huntingdon, Cambridgeshire PE18 8ED (hereinafter referred to as
"Auton") , Andrew A. Jakimcius, 1096 Heritage Drive, Saline, Michigan 48176
(hereinafter "Jakimcius") , Michael P. Kurek, 2720 Holyoke Lane, Ann Arbor,
Michigan 48103 (hereinafter referred to as "Kurek") and Steven J. Richvalsky,
12215 Deer Creek Circle, Plymouth, Michigan 48170 (hereinafter referred to as
"Richvalsky") (WPLP, Pacific, Chase, American, Bund, Yocum, Volunteer,
Mackowski-CA, Shepler, Mackowski-FL, Grove, Kalish, Boyle, Kantner, Williams,
Kent, JWilliams, Auton, Jakimcius, Kurek and Richvalsky each being sometimes
hereinafter referred to as "Lender", a "Lender" or the "Lender" and collectively
as "Lenders").

    1.   LOAN AGREEMENT.

         (a) Present Loan. Borrowers agree to borrow from each Lender, and each
Lender agrees to lend to the Borrowers on the date hereof, subject to the terms
and conditions set forth in this Agreement and all exhibits attached hereto
(hereinafter collectively "Loan Documents"), the amount set forth below opposite
the name of such Lender:

           Lender                  Amount
           ------                  ------

           WPLP                 $  492,000
           Pacific                 708,000
           Chase                 1,500,000
           American                150,000
           Bund                     17,800
           Yocum                     5,000
           Volunteer                 7,500
           Mackowski-CA            175,681
           Shepler                   5,000
           Mackowski-FL             12,748
           Grove                   175,680
           Kalish                   10,000
           Boyle                     2,500
           Kantner                   4,700
           Williams                  2,711
           Kent                    175,680
           JWilliams                19,000
           Auton                     9,500
           Jakimcius                 7,000
           Kurek                    10,500
           Richvalsky                9,000
                                     -----
                                $3,500,000

(each of the above amounts as to each respective Lender together with such
additional amount, if any, as may hereafter be borrowed from each Lender in
accordance with Section 1(c) below is hereinafter referred to as the "Loan").


                                       2
<PAGE>   8


         (b) Conditions - Present Loan. The obligation of Lender to advance any
sum pursuant to "(a)" is contingent upon, since the date of this Agreement until
the date of any advance; (1) no material adverse change shall have occurred in
the financial condition of Borrowers or in the physical condition of the assets
serving as collateral; (2) no event shall have occurred or condition exist which
constitutes or with the passage of time or the giving of notice would
constitute, any event of default; and (3) Lender's receipt of a certificate
dated the date of the request for advance, and signed by the President of Parent
stating that: a) the Borrowers have complied and are then in compliance with all
the terms and covenants of this Agreement which are binding upon them; b) there
exists no event of default as defined herein and no event which, with the giving
of notice or the lapse of time, or both, would constitute such an event of
default; and c) the representations and warranties contained herein are true
with the same effect as though such representations and warranties were made at
the time of request for advance.

         (c) Future Loan. At any time hereafter prior to January 27, 2000,
Lenders owning not less than eighty percent (80%) of the Warrants (or shares of
common stock of Parent issued upon exercise of the warrants) issued pursuant to
this Agreement shall have the right at Lenders' sole option to lend additional
funds to Borrowers upon all the same terms and provisions applicable under the
provisions of the Loan Documents (including the issuance of additional Warrants
in amounts proportional to and upon the same terms and provisions as provided in
Section 3 hereof with respect to the portion of the Loan contemplated by Section
1(a) hereof) except that the holders of the Warrants issued by Parent as part of
the April 1999 Loan Documents (as hereinafter defined) shall not be required to
waive the provisions of subsection F of such Warrants and the holders of the
Preferred Stock of Parent shall not be required to waive the provisions of
Article V, Section C(3) (e) of the Certificate of Incorporation of Parent with
respect to the issuance of such additional Warrants, provided that (i) Lenders
shall not have the right to lend to Borrowers more than $3,500,000 pursuant to
this Section 1(c), (ii) the amount of additional funds Lenders shall have the
right to lend to Borrowers pursuant to this Section 1(c) shall be reduced by any
additional funds received by Borrowers for the issuance of securities of Parent
upon terms more favorable to Borrowers than those contained in this Agreement,
and (iii) Lenders may not lend additional funds to Borrowers pursuant to this
Section 1(c) from and after such date as Parent shall execute a letter of intent
providing for the merger or consolidation of Parent or the sale of substantially
all of the assets of Parent, provided further that if the transaction
contemplated by the letter of intent referred to in "(iii)" shall not be
consummated, then the Lenders shall have the right at Lenders' sole option to
lend additional funds to Borrowers pursuant to this Section 1(c) for a period of
90 days after termination of such letter of intent or definitive agreement



                                       3
<PAGE>   9

relating to the transaction contemplated thereby. Without limiting in any manner
Lenders' right to assign their rights under the Loan Documents, Lenders may
separately assign their rights under this Section 1(c).

         (d) Additional Loan to Satisfy Preemptive Rights. Borrowers and Lenders
acknowledge that certain holders of Parent's equity securities have a preemptive
right to participate, on a pro rata basis, in the transactions contemplated by
this Agreement, which right, to the extent not waived, will expire after the
date hereof. The parties agree that if any such holder properly exercises such
preemptive right, as described in the preceding sentence, then Borrowers shall
borrow from such holder an amount determined by such holder, which amount shall
not exceed such holder's pro rata share of all amounts borrowed by Borrowers
under Section 1(a) and this Section 1(d), all upon the terms and conditions set
forth in the Loan Documents. If the aggregate amount loaned to Borrowers under
Section 1(a) and this Section 1(d) of this Agreement exceeds $3,750,000, then
the warrants issued by Parent in respect of the excess (i) shall not be treated
as Excluded Stock under Article V, Section 3e(v) of Parent's Certificate of
Incorporation, as amended, and (ii) shall constitute "Additional Shares of
Common Stock" for purposes of subsection G of the Warrants issued pursuant to
Section 3 of this Agreement. The parties shall amend the Loan Documents or
execute and deliver additional documents as necessary to reflect any such
additional loans to Borrowers pursuant to this Section 1(d).

     2. EXECUTION OF NOTES. The obligation to repay the Loan of each Lender
shall be evidenced by Borrowers' Promissory Note in the form set forth in
Exhibit A attached hereto (each Promissory Note executed and delivered to a
Lender hereinafter being referred to as a "Note" and collectively as the
"Notes").

     3. EQUITY-INITIAL ISSUANCE.

         (a) Warrants-Non-Cancellable. Parent shall issue to each Lender at the
time of closing the Loan, in consideration for the granting of the Loan, and
payment by Lenders concurrently with execution and delivery of this Agreement of
$.0001 per share of common stock, negotiable Warrants to acquire the following
shares of common stock of Parent:

           Lender                         Warrants
           ------                         --------
           WPLP                            72,816
           Pacific                        104,784
           Chase                          222,000
           American                        22,200
           Bund                             2,634
           Yocum                              740
           Volunteer                        1,110
           Mackowski-CA                    26,001
           Shepler                            740

                                       4


<PAGE>   10

           Mackowski-FL                     1,887
           Grove                           26,001
           Kalish                           1,480
           Boyle                              370
           Kantner                            696
           Williams                           401
           Kent                            26,001
           JWilliams                        2,812
           Auton                            1,406
           Jakimcius                        1,036
           Kurek                            1,553
           Richvalsky                       1,332

The Warrants issued shall be in the form set forth in Exhibit B-1 attached
hereto.

         (b) Warrants-Cancellable Upon $5.00 Liquidity Event. Parent shall
issue to each Lender at the time of closing the Loan, in consideration for the
granting of the Loan, and payment by Lenders concurrently with execution and
delivery of this Agreement of $.0001 per share of common stock, negotiable
Warrants, subject to cancellation and surrender in accordance with the terms
thereof, to acquire the following shares of common stock of Parent:

           Lender                         Warrants
           ------                         --------
           WPLP                             85,959
           Pacific                         123,698
           Chase                           262,071
           American                         26,207
           Bund                              3,110
           Yocum                               874
           Volunteer                         1,310
           Mackowski-CA                     30,694
           Shepler                             874
           Mackowski-FL                      2,227
           Grove                            30,694
           Kalish                            1,747
           Boyle                               437
           Kantner                             821
           Williams                            474
           Kent                             30,694
           JWilliams                         3,320
           Auton                             1,660
           Jakimcius                         1,223
           Kurek                             1,834
           Richvalsky                        1,572

The Warrants issued shall be in the form set forth in Exhibit B-2 attached
hereto.

         (c) Warrants-Cancellable Upon Premium Liquidity Event. Parent shall
issue to each Lender at the time of closing the Loan, in consideration for the
granting of the Loan, and payment

                                        5


<PAGE>   11

by Lenders concurrently with execution and delivery of this Agreement of $.0001
per share of common stock, negotiable Warrants, subject to cancellation and
surrender in accordance with the terms thereof, to acquire the following shares
of common stock of Parent:

           Lender                                          Warrants
           ------                                          --------
           WPLP                                              13,425
           Pacific                                           19,318
           Chase                                             40,929
           American                                           4,093
           Bund                                                 486
           Yocum                                                136
           Volunteer                                            205
           Mackowski-CA                                       4,793
           Shepler                                              136
           Mackowski-FL                                         348
           Grove                                              4,793
           Boyle                                                 68
           Kalish                                               273
           Kantner                                              128
           Williams                                              74
           Kent                                               4,793
           JWilliams                                            518
           Auton                                                259
           Jakimcius                                            191
           Kurek                                                288
           Richvalsky                                           246

The Warrants issued shall be in the form set forth in Exhibit B-3 attached
hereto.

     4. There is no Section 4.

     5. SECURITY, ASSURANCES AND INSURANCE. To secure the faithful performance
of this Agreement and the repayment of the indebtedness created hereunder,
Borrowers shall do the following:

         (a) Collateral. Parent gives, assigns, and conveys to each Lender, as
collateral, a security interest pursuant to the Security Agreement in the form
set forth in Exhibit C attached hereto in all accounts receivable, inventory,
equipment, furniture, fixtures, notes receivable, and all other tangible and
intangible assets and after-acquired property (all assets) of Parent subject
only to a (i) prior security interest of Comerica Bank and the terms of a
subordination agreement satisfactory to Lender, or of a successor bank which
replaces Comerica Bank under similar credit facilities, provided that any such
successor enters into a subordination agreement substantially in the form of the
Subordination Agreement attached hereto as Exhibit D (Comerica Bank and any such
successor bank each being sometimes hereinafter referred to as the "Senior
Lender"), and (ii) the security interest granted to the parties to the Business
Loan Agreement dated April 23, 1999 (which Business Loan Agreement,

                                        6


<PAGE>   12


together with all other materials referred to therein as "Loan Documents" are
hereinafter sometimes collectively referred to as the "April 1999 Loan
Documents").

         (b) Pledge. Parent shall pledge all of its right, title and interest in
its 100%. ownership interest in the Subsidiaries pursuant to the Pledge
Agreement in the form attached hereto as Exhibit H.

         (c) Subsidiaries' Security Each Subsidiary with property located in any
state of the United States gives, assigns, and conveys to each Lender, as
collateral, a security interest pursuant to the Security Agreement in the form
set forth in Exhibit C attached hereto in all accounts receivable, inventory,
equipment, furniture, fixtures, notes receivable, and all other tangible and
intangible assets and after-acquired property (all assets) of such Subsidiary
subject only to a prior security interest of the Senior Lender. Each Subsidiary
with property located outside the United States shall execute such documentation
as may be necessary to grant to Lenders an interest equivalent to a security
interest or chattel mortgage as may be possible under the laws of each
jurisdiction in which any property of such Subsidiary may be located.

         (d) Insurance-Property. Each Borrower shall maintain, without expense
to Lenders, a policy or policies of insurance with respect to the collateral, in
an amount which is at least equal to the fair market value thereof, naming the
Lender as an insured party as its interest may appear and said policy shall
contain a provision requiring that the insurer provide at least thirty (30) days
notice to the Lender prior to cancellation of said insurance. The Borrower shall
deliver a certificate of such insurance to the Lender.

         (e) Insurance-Life. Borrowers shall maintain, without expense to
Lenders, $3,500,000 term life insurance on the life of Jeffrey S. Williams with
Lenders as irrevocable beneficiaries. Borrowers shall apply for additional
amounts of such insurance on the lives of Jeffrey S. Williams, Steven J.
Richvalsky, Andrew A. Jakimcius and Michael P. Kurek (in such amount on the life
of each such individual as may hereafter be agreed by Lenders and Borrowers, or
in the absence of such agreement, in equal amounts on the life of each such
individual) prior to closing of any portion of the Loan contemplated by Section
1(c) hereof in an amount equal to such additional portion of the Loan, and shall
deliver such additional policy or policies of insurance to Lenders when issued.
Any insurance proceeds shall be applied in payment of the Notes and any other
amounts which may be due Lenders under the Loan Documents. If any insurance
proceeds remain after payment of the Notes and any other amounts due Lenders
under the Loan Documents, Lenders shall promptly pay over such remaining amount
of insurance proceeds to Borrower.


                                       7

<PAGE>   13

         (f) Further Assurances. On demand of the Lender, the Borrowers shall
furnish further assurances of title, execute any written agreement, or do any
other acts, execute any instrument or statement required by law or otherwise, in
order to perfect and continue the security interest of the Lender in the
collateral, including without limitation, that Parent shall amend the Pledge
Agreement contemplated by Section 5(b) above to subject to the terms and
provisions of such Pledge Agreement any interest Parent may hereafter acquire in
any corporation, partnership, limited liability company or other entity, and
cause any such corporation, partnership, limited liability company or other
entity in which Parent has a majority interest to comply with the provisions of
Section 5(c) hereof.

     6. CONDITIONS OF LOAN. The obligation of each Lender to make the Loan is
subject to the following conditions precedent:

         (a) Approval Of Lender's Counsel. All legal matters incident to the
Loan shall be satisfactory to all counsel for the Lender.

         (b) Representations And Warranties. All representations and warranties
by the Borrowers which are contained in this Agreement and the statements
contained in the Exhibits, Schedules and Loan Documents or any instrument, list,
certificate or writing delivered to the Lender pursuant to this Agreement shall
be, in all respects, true and correct on and as of the loan closing date as
though such representations and warranties were made at and as of the loan
closing date, and the Lender shall have not discovered any material misstatement
or omission in the representations and warranties made in this Agreement.

         (c) Compliance. Borrowers shall have performed and complied in all
material respects with all of their obligations under this Agreement which are
to be performed or complied with by the Borrowers prior to or on the Loan
closing date.

         (d) Evidence Of Corporate Action. The Lender shall have received
certified copies of all corporate or other required action taken by each
Borrower to authorize this Agreement, the Loan Documents and the borrowing
hereunder, and such other documents as the Lender may reasonably require
relating to the existence of the Borrowers, the authority for and the validity
of this Agreement, the Note and the Warrants, and any other matters relevant
hereto, all in form and substance satisfactory to Lender's counsel, and
indicating the name and title of the officer or officers of each Borrower
authorized to sign this Agreement and the Loan Documents.

         (e) Opinion Of Borrower's Counsel. The Lender shall have received a
favorable written opinion of counsel for the Borrowers, dated the date of the
Loan in the form of Exhibit E which is attached hereto.

                                       8

<PAGE>   14

         (f) SBA Forms. Parent shall have executed and delivered to Lenders SBA
Form 1031, PART A of which shall have been completed by Parent, and SBA Forms
652-D and 480.

         (g) Certificates. The Lender shall have received from each Borrower a
certificate of good standing and a certified copy of the Articles or Certificate
of Incorporation for such Borrower (as amended). All shall be certified by the
appropriate governmental agency as being true, correct and complete as of the
date of such certification.

         (h) Bylaws. The Lender shall have received from each Borrower a copy of
the Bylaws of such Borrower and all amendments thereto, certified by the
Secretary of such Borrower as being true, correct and complete as of the date of
such certification.

         (i) Insurance. Evidence satisfactory to the Lender that the Borrowers
have obtained the insurance policies required by the Lender including but not
limited to liability insurance and worker's compensation insurance with limits
and carriers reasonably satisfactory to the Lender, and the life insurance
contemplated by Section 5(e) hereof.

         (j) Due Diligence. Lender has reached no adverse findings as a result
of their continued due diligence investigation of each Borrower, its management,
its future financing needs, and its industry, or any environmental review as of
the closing date.

         (k) There is no Section 6(k).

         (1) Subordination. Any stock redemption agreements between Parent and
any of its shareholders shall be subordinate to all obligations created pursuant
to this Loan Agreement including, but not limited to the Note and the Warrants
and such subordination shall be consented to by the shareholders of Parent. Any
debt owed by any Borrower to any of its shareholders (other than by Subsidiaries
to Parent), directors, or officers including all future indebtedness shall be
subordinated to all obligations created by the Loan documents including but not
limited to the Note and Warrants, pursuant to a subordination agreement
reasonably satisfactory to Lenders.

         (m) Receipt Of Executed Documents. The Lender shall have received each
of the following, in form and substance satisfactory to the Lender and its
respective counsel:

               (i) the Note duly executed by the Borrowers and the Warrants duly
executed by Parent;

               (ii) the Security Agreement duly executed by Parent, and as
applicable, each Subsidiary, together with:

                                       9


<PAGE>   15

                    (a) evidence of the due execution and delivery of, and the
recordation, filing and other action in such jurisdictions as the Lender may
deem necessary or appropriate with respect to the Security Agreement, Financing
Statements and similar documents which the Lender deems necessary or desirable
to create, preserve or perfect the liens, security interests and other rights
intended to be granted to the Lender thereunder.

                    (b) a schedule setting forth all real property owned or
leased by any Borrower, together with copies of the related leases, certified as
true and correct as of the effective date by a duly authorized officer of
Borrower.

               (iii) an amendment to the Registration Rights Agreement dated
April 23, 1999 duly executed by Parent in the form of Exhibit F which is
attached hereto;

               (iv) an amendment to the Shareholders Agreement dated December
24, 1997, as amended May 27, 1998 and April 23, 1999 (the "Shareholders
Agreement"), duly executed by appropriate shareholders and Parent in the form of
Exhibit G which is attached hereto;

               (v) Acceptable subordination agreements executed by appropriate
shareholders, directors, officers and Borrowers;

               (vi) Satisfactory Uniform Commercial Code search;

               (vii) the Pledge Agreement duly executed by Parent;

               (viii) Acceptable nondisclosure agreements executed by such key
management, operating and technical personnel as Lenders may reasonably require;

               (ix) each Borrower shall execute and deliver such other
instruments and certificates as the Lender may reasonably request to effect the
closing.

         (n) Consents. All consents, approvals, permits, licenses,
authorizations, agreements and other items required, or deemed by the Lender to
be required for the carrying out of the transactions contemplated in this
Agreement, shall have been obtained in form and substance reasonably
satisfactory to the Lender.

     7. REPRESENTATIONS AND WARRANTIES. Each Borrower, jointly and severally,
represents and warrants to Lender, all of which representations and warranties
shall be continuing and shall survive the execution of this Agreement until all
of the indebtedness is fully paid to Lender and Borrowers' obligations under
this Agreement and the related documents are fully performed as follows:

                                       10


<PAGE>   16
         (a) Organization and Standing; Charter and Bylaws. Parent is a
corporation duly organized, validly existing and in good standing under the laws
of the State of Delaware, and Parent is authorized to exercise all of its
corporate powers, rights and privileges. Genomic UK is a corporation duly
organized, validly existing and in good standing under the laws of the United
Kingdom, and Genomic UK is authorized to exercise all of its corporate powers,
rights and privileges. Genomic Japan is a corporation duly organized, validly
existing and in good standing under the laws of Japan, and Genomic Japan is
authorized to exercise all of its corporate powers, rights and privileges. Each
Borrower has all required corporate power and authority to own its property and
to carry on its business as presently conducted or contemplated. True and
accurate copies of the Articles or Certificate of Incorporation and the Bylaws
of each Borrower, as in effect on the date hereof, have been delivered to the
Lenders.

         (b) Capitalization. The authorized capital stock of Parent on the date
hereof consists of 40,000,000 shares of Common Stock, par value $.001 per share
("Common Stock") and 10,000,000 shares of Preferred Stock, par value $.001 per
share (the "Preferred Stock"). On the date hereof, 3,012,509 shares of Common
Stock are outstanding. Of the authorized Preferred Stock, 1,100,000 shares have
been designated Series D Preferred Stock, 4,070,339 shares have been designated
Series C Preferred Stock, 1,680,880 shares have been designated Series B
Preferred Stock and 50,000 have been designated Series M Preferred Stock. On the
date hereof, 1,100,000 shares of Series D Preferred Stock are outstanding,
4,070,339 shares of Series C Preferred Stock are outstanding, 1,680,880 shares
of Series B Preferred stock are outstanding and 50,000 shares of Series M
Preferred Stock are outstanding. The several classes and series of capital stock
have the rights, preferences and privileges set forth in the Certificate of
Incorporation. Parent has reserved 1,100,000 shares of Common Stock for issuance
upon conversion of the Series D Preferred Stock, 4,070,339 shares of Common
Stock for issuance upon conversion of the Series C Preferred Stock, 5,093,576
shares of Common Stock for issuance upon conversion of the Series B Preferred
Stock, 270,027 shares of Common Stock for issuance upon conversion of the Series
M Preferred Stock, and 1,400,000 shares of Common Stock for issuance upon
exercise of Warrants issued pursuant to the April 1999 Loan Documents. As of the
date of this Agreement, the Conversion Price of the Series B Preferred Stock is
$.33 per share of common stock, the Conversion Price of the Series C Preferred
Stock is $1.75 per share of common stock, the Conversion Price of the Series D
Preferred Stock is $6.00 per share of common stock and the Conversion Price of
the Series M Preferred Stock is $1.111 per share of common stock, and there has
been no event, including the issuance of any shares of common stock of Parent,
or securities convertible into or exercisable for shares of common stock of
Parent, which could result in any adjustment in any of the foregoing Conversion
Prices pursuant to the provisions of the Certificate of Incorporation of Parent

                                       11


<PAGE>   17

except as to the Series M Preferred Stock, the transactions provided for in the
April 1999 Loan Documents and the Loan Documents, and the issuance of shares of
common stock or options to acquire common stock pursuant to any option or
incentive plan approved by the Board of Directors of Parent. As a result of
Parent's merger with B.I. Systems Corporation, a Delaware corporation ("BISC"),
Parent assumed the 1994 Omnibus Equity Incentive Plan of BISC (the "BISC
Plan"), which was adopted by the Board of Directors and shareholders of BISC in
July 1994 and amended in April 1997. On January 15, 1998, Parent's Board of
Directors adopted the Genomic Solutions Inc. Non-Employee Stock Option Plan (the
"Non-Employee Plan") and the 1998 Genomic Solutions Inc. Stock Option Plan (the
"Employee Plan"). On the date of the Closing, options to acquire 710,438 shares
of Common Stock are outstanding pursuant to the BISC Plan, options to acquire
1,111,450 shares of Common Stock are outstanding pursuant to the Employee Plan
and options to acquire 245,000 shares of Common Stock are outstanding pursuant
to the Non-Employee Plan. Parent has reserved 2,066,888 shares of Common Stock
for issuance upon exercise of these options. Except as set forth herein and in
Schedule 7(b), there are no outstanding rights, options, warrants, preemptive
rights, conversion rights or agreements for the purchase, acquisition or receipt
from Parent of any shares of capital stock or any other securities of Parent.
Parent is not a party to any existing agreement with any person or entity which
requires Parent to purchase from such person or entity any of its capital stock,
any securities convertible into or exchangeable or exercisable for any of its
capital stock, or any right, options or warrants for its capital stock. All
outstanding securities of Parent, including the Notes and Warrants, have been
issued in accordance with all applicable state and Federal securities laws.

         (c) Corporate Power; Authorization. Parent has all requisite legal and
corporate power to enter into this Agreement, to issue and sell the Notes and
Warrants as provided hereunder, and to carry out and perform its obligations
under the terms of the Loan Documents. Each Subsidiary has all requisite legal
and corporate power to enter into this Agreement, to issue and sell the Notes as
provided hereunder, and to carry out and perform its obligations under the terms
of this Agreement. All corporate action on the part of each Borrower and its
officers, directors and shareholders that is necessary for the authorization,
execution and delivery of this Agreement and the Loan Documents by such
Borrower, for the performance of the Borrower's obligations thereunder and for
the issuance and delivery of the Notes, and as to Parent the Warrants, has been
taken; and this Agreement, the Notes, Warrants, Security Agreement, Pledge
Agreement and all other Loan Documents constitute a legal and binding obligation
of each Borrower a party thereto, enforceable against each Borrower in
accordance with its terms subject to: (i) judicial principles respecting or
limiting the availability of specific performance, injunctive relief and other
equitable remedies; and (ii) bankruptcy, insolvency, reorganization, moratorium
or other similar laws now or hereafter in effect generally relating to or
affecting creditors' rights. No Borrower is in violation of any term of its
Articles or Certificate of Incorporation or Bylaws, or in violation of any

                                       12


<PAGE>   18

term of any judgment, decree, order, statute, rule or government regulation
applicable to such Borrower or to which the Borrower is a party. No Borrower is
in violation of any term of any agreement or instrument applicable to such
Borrower or to which the Borrower is a party where such violation is likely to
be materially adverse to such Borrower's financial condition, business or
operations.

         (d) Validity of Securities. The Notes and Warrants, when issued, sold
and delivered in accordance with the terms of this Agreement, will be duly and
validly issued, and will be free and clear of any liens, encumbrances or
restrictions of any kind; provided, however, that the Notes and Warrants may be
subject to restrictions on transfer under state and federal securities laws and
the Warrants are subject to the Shareholders Agreement among the Parent and the
Shareholders (as defined therein). The Common Stock issuable upon exercise of
the Warrants has been duly and validly reserved and, upon issuance in accordance
with the terms of the Warrants, will be duly and validly issued, fully paid and
non-assessable and will be free and clear of any liens, encumbrances or
restrictions of any kind; provided, however, that the Common Stock may be
subject to restrictions on transfer under state and federal securities laws and
the Shareholders Agreement.

         (e) Consents and Waivers. Each Borrower has obtained any and all
consents, permits and waivers and made all filings necessary or appropriate
for consummation of the transactions contemplated by this Agreement.

         (f) Litigation. Except as set forth in Schedule 7(f), there is no
action, suit or proceeding pending or, to the knowledge of any Borrower,
threatened against any Borrower or related to the business conducted by such
Borrower. No Borrower is a party or subject to the provisions of any order,
writ, injunction, judgment or decree of any court or government agency or
instrumentality. There is no action, suit, proceeding or investigation by any
Borrower currently pending or which any Borrower intends to initiate.

         (g) Shareholder Lists and Agreements; Officers and Directors. Set forth
on Schedule 7(g) is a true and complete list of all shareholders of Parent and
persons holding options or warrants to acquire shares of Parent, showing the
number of shares of capital stock held, or acquirable upon exercise of the
option or warrant, by each such person in each case as of the date of this
Agreement. Schedule 7(g) also sets forth the names of the officers and directors
of each Borrower and all indebtedness of the officers, directors, shareholders
and any of their respective close relatives, to the Borrowers. Except as set
forth on Schedule 7(g), none of the officers or directors or significant
employees of any Borrower or their respective close relatives, owns directly or
indirectly, individually or collectively, any interest in any entity which is a
competitor, customer or supplier of (or has any existing contractual


                                       13



<PAGE>   19

relationship with) any Borrower other than ownership of less than one percent
(1%) of any publicly traded securities of any entity or of an interest in any
entity through ownership of publicly traded shares of any mutual fund.

         (h) Subsidiaries. Except as set forth on Schedule 7(h), Parent has no
subsidiaries and does not own, directly or indirectly, any interest in any
corporation, association or business entity. All outstanding shares of capital
stock of each class of each Subsidiary is owned beneficially and of record by
Parent.

         (i) Financial Statements.

               (a) Schedule 7(i) attached hereto contains true, correct and
complete copies of:

                    (i) the audited consolidated and consolidating balance sheet
of the Borrowers, as of December 31, 1998, and the related statements of
operations, stockholders, equity (deficit) and cash flows of the Borrowers for
the period covered thereby, including the footnotes thereto (all of foregoing
being hereinafter collectively called the "Annual Financial Statements"); and

                    (ii) the interim unaudited consolidated and consolidating
balance sheet of the Borrowers (the "Interim Balance Sheet") as of August 31,
1999 (the "Interim Balance Sheet Date"), and the interim statements of
operations of the Borrowers for the eight (8) month period then ended (all of
the foregoing, including the Interim Balance Sheet, being hereinafter
collectively referred to as the "Interim Financial Statements" and together with
the Annual Financial Statements collectively, the "Financial Statements").

               (b) The Financial Statements taken as a whole (A) fairly present
in all material respects (subject, in the case of the Interim Financial
Statements, to normal, recurring year-end adjustments which are not material
individually or in the aggregate) the financial position of the Borrowers as of
the dates indicated and the results of operations of the Borrowers for the
periods indicated, (B)(x) have been prepared in accordance with Generally
Accepted Accounting Principles ("GAAP") consistently applied throughout the
periods covered thereby (subject, in the case of the Interim Financial
Statements, to normal, recurring year-end adjustments which are not material
individually or in the aggregate) or (y) to the extent not prepared in
accordance with GAAP, then footnotes to the Financial Statements will be
provided describing in reasonable detail the differences, if any, between the
accounting principles pursuant to which such Financial Statements were in fact
prepared and GAAP and (C) are in accordance with the books and records of the
Borrowers which have been maintained in a manner consistent with



                                       14
<PAGE>   20

historical practice. All reserves established and set forth in the
Interim Balance Sheet are reasonable and adequate.

         (j) Absence of Undisclosed Liabilities. The Borrowers have no
liabilities or obligations of any nature, whether matured or unmatured, known or
unknown, or fixed or contingent, except (a) to the extent expressly reflected or
reserved against on the Interim Balance Sheet or expressly disclosed in the
notes thereto; and (b) liabilities and obligations arising since the Interim
Balance Sheet Date in the ordinary course of business consistent with past
practice (other than any such liability or obligation arising from breach of
contract, breach of warranty, tort, infringement, or violation of any legal
requirement).

         (k) Absence of Certain Developments. Except as reflected in the
Financial Statements or in Schedule 7(k), since the Interim Balance Sheet Date,
there has been (i) no material adverse change in the condition (financial or
otherwise) of the Borrowers or in the assets, liabilities, or properties of the
Borrowers; (ii) no declaration, setting aside or payment of any dividend or
other distribution with respect to, or any direct or indirect redemption or
acquisition of, any of the capital stock of Parent; (iii) no waiver of any
valuable right of the Borrowers or cancellation of any debt or claim held by the
Borrowers; (iv) no loan by any Borrower to any officer, director, employee or
shareholder of a Borrower, or any agreement or commitment therefor; (v) no
increase, direct or indirect, in the compensation paid or payable to any
officer, director, employee or agent of any Borrower; (vi) no material loss,
destruction or damage to any property of a Borrower, whether or not insured;
(vii) no labor disputes involving a Borrower and no material change in the
personnel of a Borrower or the terms and conditions of their employment; and
(viii) no acquisition or disposition of any assets (or any contract or
arrangement therefor), nor any other transaction by a Borrower otherwise than
for fair value in the ordinary course of business.

         (1) Title to Assets. Each Borrower has good and marketable title to all
of the assets reflected as being owned by such Borrower on the Interim Balance
Sheet or acquired subsequent thereto (except for inventory sold or otherwise
disposed of in the ordinary course of business for fair value and accounts and
notes receivable paid in full since the date of the Interim Balance Sheet), free
and clear of all encumbrances, except for those encumbrances set forth on
Schedule 7(l) and Permitted Liens. Such assets are in good operating condition
and repair (normal wear and tear excepted), are adequate and suitable for the
uses for which they are used in such Borrower's business, are not subject to any
condition which interferes with the economic value or use thereof, and
constitute all assets necessary to permit each Borrower to carry on its business
after the consummation of the transactions contemplated by this Agreement as
generally conducted by such Borrower prior thereto. The term "Permitted Liens"
means (i) liens arising by operation of law in


                                       15


<PAGE>   21

the ordinary course of business that, individually and in the aggregate, do not
in any material respect interfere with the use of any of the assets subject
thereto; (ii) minor imperfections of title which do not materially detract from
the value of the property affected or materially impair the operations of any
Borrower; (iii) liens for taxes not yet due and payable; and (iv) landlords
liens, if any, relating to leases.

         (m) Real Property. Borrowers do not own directly or indirectly any real
property.

         (n) Tax Matters. Each Borrower has filed all federal, state and local
income, excise or franchise tax returns, real estate and personal property tax
returns, sales and use tax returns and other tax returns required to be filed by
it and has paid all taxes owed by it, except taxes which have not yet accrued or
otherwise become due or for which adequate provision has been made in the
pertinent Financial Statements. The provision for taxes on the Interim Balance
Sheet is sufficient as of its date for the payment of all accrued and unpaid
federal, state, county and local taxes of any nature of each Borrower whether or
not assessed or disputed. All taxes and other assessments and levies which any
Borrower is required to withhold or collect have been withheld and collected and
have been paid over when due to the proper governmental authorities. With regard
to the income tax returns of the Borrowers, no Borrower has received notice of
any audit or of any proposed deficiencies from any taxing authority and no
controversy with respect to taxes of any type is pending or, to the knowledge of
any Borrower, threatened. There are in effect no waivers of applicable statutes
of limitations with respect to any taxes owed by any Borrower for any year.

         (o) Contracts and Commitments. Except as set forth in Schedule 7(o),
no Borrower (i) is a party to any contract, obligation or commitment which
involves a potential commitment in excess of $100,000 or which is otherwise
material and not entered into in the ordinary course of business; and (ii) has
any employment contracts; stock redemption or purchase agreements; financing
agreements; licenses; distributor or sales representative agreements;
agreements with officers, directors, employees or shareholders of such Borrower
(other than between Parent and a Subsidiary) or persons or organizations related
to or affiliated with any such persons; leases; agreements relating to product
development; or pension, profit-sharing, retirement or stock option plans. Each
agreement or understanding set forth on Schedule 7(o) is in full force and
effect and constitutes a valid and binding obligation of the Borrower and to the
best knowledge of such Borrower, the other party thereto. Each Borrower has in
all material respects performed the obligations required to be performed by it
except for obligations not yet due to be performed and each Borrower is and has
not been in default or received notices that it is in default in any material
respect under any such agreement or understanding. There exists no known

                                       16


<PAGE>   22

event or condition which, after notice or lapse of time, or both, would
constitute such a default. There are no material defaults by any other party to
any such agreement or understanding as to which any notice of default has been
given. Each Borrower has made available to the Lenders correct and complete
copies of all documents set forth on such Schedule.

         (p) Proprietary Rights; Employee Restriction. Borrowers have disclosed
on Schedule 7(p), all copyright registrations, trademark registrations and
applications for registration, patents and patent applications, trademarks,
trade secrets or other proprietary rights (collectively, "Intellectual Property
Rights") used or, to the best of Borrowers' knowledge, to be used in Borrowers'
business as presently conducted or contemplated and all licenses, assignments
and leases relating to Intellectual Property Rights of others embodied in
products of the Borrowers. Borrowers have exclusive ownership of or license to
use, all Intellectual Property Rights identified in Schedule 7(p) and, to the
best knowledge of Borrowers have obtained any licenses, releases or assignments
to use all third parties' Intellectual Property Rights embodied in products of
the Borrowers. To the best knowledge of the Borrowers, neither the present nor
contemplated business activities or products of the Borrowers infringe any
Intellectual Property Rights of others. No Borrower has received any notice or
other claim from any person asserting that any of such Borrower's present or
contemplated activities infringe or may infringe any Intellectual Property
Rights of such person. Each Borrower has the right to use, free and clear of
claims or rights of others, all trade secrets, customer lists, manufacturing
processes, hardware designs, programming processes, software and other
information required for or incident to its products or its business as
presently conducted or contemplated. Each Borrower has taken all commercially
reasonable steps to establish and preserve its ownership of all copyright, trade
secret and other proprietary rights with respect to its products and technology,
except such rights as such Borrower has reasonably determined are not material
to such Borrower's continuing business operations. No Borrower is aware of any
infringement by others of its copyrights or other Intellectual Property Rights
to which it has exclusive use in any of its products, technology or services, or
any violation of the confidentiality of any of its proprietary information. No
Borrower is making unlawful use of any confidential information or trade secrets
of any past or present employees of such Borrower. Except as set forth in
Schedule 7(p), neither any Borrower nor, to each Borrower's knowledge, any of
the key employees of such Borrower have any agreements or arrangements with
former employers of such employees relating to confidential information or trade
secrets of such employers. The activities of each Borrower's employees on behalf
of such Borrower do not violate any agreements or arrangements known to such
Borrower which any such employees have with former employers.

                                       17


<PAGE>   23


         (q) Effect of Transactions. The execution, delivery and performance by
Borrowers of this Agreement and the documents executed and delivered in
connection therewith will not conflict with or result in any default under any
material contract obligation or commitment of any Borrower, or any charter
provision, bylaw or corporate restriction of any Borrower, or the creation of
any lien, charge or encumbrance of any nature upon any of the properties or
assets of any Borrower, except pursuant to this Agreement. Each Borrower's
execution and delivery of this Agreement and the documents executed and
delivered in connection therewith and its performance of the transactions
contemplated thereby will not violate any instrument, agreement, judgment,
decree, order, statute, rule or regulation of any federal, state or local
government or agency applicable to such Borrower.

         (r) Insurance. Each Borrower maintains valid and effective insurance
policies, issued by financially sound and reputable insurers, to insure it
against all risks usually insured against by persons or entities conducting
businesses similar to that of such Borrower in the locality in which such
businesses are conducted. Each Borrower has paid all due premiums with respect
to all policies of insurance currently maintained by such Borrower.

         (s) Securities Act Registration. Assuming that the representations and
warranties of the Lenders contained herein are true, the offer, sale and
delivery of the Notes and Warrants in the manner contemplated by this Agreement
are each exempt from registration under the Securities Act and are exempt or
will be exempt under applicable state securities or Blue Sky laws regulating the
issuance or sale of securities upon the timely filing of notices with the
appropriate states.

         (t) Business; Compliance with Laws. Each Borrower (i) is in compliance
with, in all respects all legal requirements applicable to it and its business
and (ii) has all material federal, state, local and foreign governmental
licenses and permits (collectively, "Permits") used or necessary in the conduct
of its business. Such Permits are in full force and effect, no violations with
respect to any thereof are recorded, no legal proceeding is pending or, to the
best knowledge of each Borrower, threatened to revoke or limit any thereof.

         (u) Books and Records. The minute books of each Borrower contain
complete and accurate records of all meetings and other corporate actions of its
shareholders and its board of directors (the board of directors of Parent being
herein referred to as the "Board of Directors") and committees thereof. The
stock ledger of Parent is complete and reflects all issuances, transfers,
repurchases and cancellations of shares of capital stock of Parent.


                                       18


<PAGE>   24

         (v) Employee Benefit Plans. Each employee benefit plan, program,
arrangement, practice or contract, whether formal or informal, maintained or
contributed to by any Borrower providing current or retirement benefits or
compensation to or on behalf of employees or former employees of such Borrower
(the "Benefits Plans"), are in compliance in all material respects with the
presently applicable laws.

         (w) Small Business Matters. Parent (including the Subsidiaries) is a
"small business concern" within the meaning of the Small Business Investment Act
of 1958 and the regulations thereunder (the "SBIC Act"), including Title 13,
Code of Federal Regulations, ss.121.301. The information set forth in the Small
Business Administration Forms 480, 652 and Sections A and B of Form 1031, which
have been delivered on or prior to the date hereof to the Lenders regarding the
Borrowers is accurate and complete. Parent does not presently engage in, and it
shall not hereafter engage in, any activities, nor shall Parent use directly or
indirectly the proceeds from the sale of the Notes and Warrants for any purpose
for which a Small Business Investment Corporation is prohibited from providing
funds by the SBIC Act, including Title 13, Code of Federal Regulations,
ss.107.720. Parent acknowledges that it has been declared by each of WPLP,
Pacific and Chase that each such entity is a federal licensee under the SBIC
Act.

         (x) Information Supplied to the Lenders.

               (i) Neither this Agreement, or the Schedules and Exhibits
attached hereto, nor any written document (including the Business Plan attached
hereto as Schedule 7(x)), certificate, projection or statement furnished to the
Lenders by or on behalf of the Borrowers pursuant to this Agreement contains any
untrue statement of a material fact, and none of this Agreement, the Schedules
and Exhibits attached hereto or such other written documents, projections,
certificates and statements omits to state a material fact necessary in order to
make the statements contained herein or therein not misleading. There is no
material fact relating to the business, prospects, operations, affairs or
conditions of the Borrowers which adversely affects or in the future may, in the
reasonable business judgment of the Borrowers, adversely affect the same which
has not been set forth in this Agreement or in the Schedules or Exhibits
attached hereto or other materials delivered pursuant to this Agreement.

               (ii) The projections contained in the Business Plan are based
upon assumptions believed by Borrowers to be reasonable as of the date hereof,
however Borrowers give no assurance that the actual operations of Borrowers will
conform to such projections.

               (iii) Any disclosure contained in any of the Schedules delivered
hereunder, which on its face is clearly and


                                       19

<PAGE>   25

unequivocally applicable to another Schedule to this Agreement, shall be deemed
made with respect to such other Schedule.

         (y) Employees. No Borrower has a collective bargaining agreement with
any of its employees. There is no labor union organizing activity pending nor,
to the best knowledge of any Borrower, threatened with respect to such Borrower.
No Borrower is aware that any officer or key employee intends to terminate his
or her relationship with such Borrower, nor does any Borrower have any present
intention of terminating the employment of any officer or key employee.

         (z) Business operations. Borrowers represent and warrant that Borrowers
design, develop, manufacture, and market integrated, high-throughput biochip and
proteomic systems and services for analyzing and quantifying biomolecules, such
as DNA, RNA, and proteins. Except as set forth on Schedule 7(z) hereto,
Borrowers have not, during the five years preceding the date of this Agreement,
been known as or used any other corporate, trade or fictitious name, nor
acquired all or substantially all of the assets, capital stock or operating
units of any person, nor had a business location at any address other than the
addresses set forth in the heading of this Agreement.

         (aa) Collectibility of Accounts Receivable. The accounts receivable of
Borrowers which are shown on the August 31, 1999 balance sheet or thereafter
acquired by Borrowers are good and collectible at the aggregate recorded amounts
thereof (subject to no defense, counterclaim or set-off) except to the extent of
the reserves provided for such receivables on such balance sheet and all such
accounts receivable arose in the normal course of the business of Borrowers.

         (bb) Inventory. All inventories reflected in the Interim Financial
Statements or acquired thereafter (the "Inventories") of each Borrower are
usable in the ordinary course of its business, have been recorded in amounts not
in excess of the cost for such items and consist solely of inventories of the
kind and quality regularly used in the Borrower's business. On the closing date,
such Inventories shall be in amounts reasonably related to the normal
requirements of the Borrower's business and will be usable and the finished
goods Inventories will be readily saleable all in the ordinary course of the
Borrower's business.

     8. AFFIRMATIVE COVENANTS. As of the date of this Agreement and continuing
until Borrowers' obligations under this Agreement, the Notes, the Warrants, and
all Loan Documents are fully performed, including that the Notes are fully paid
to Lender, Borrowers shall at all times:

         (a) Financial Statements. Furnish to the Lender the following
consolidated and consolidating balance sheets and statements of income and
retained earnings of the Borrowers prepared on the accrual basis according to
generally accepted

                                       20


<PAGE>   26

accounting principles consistently applied: (1) monthly financial statements
containing at a minimum a balance sheet and income statement together with
analyses of variances from the annual operating Budget and Business Plan, and
such further detail as shall be reasonably requested by Lender from time to
time, no later than thirty (30) days after the end of each month, certified as
true and correct by an officer of Parent; (2) copies of monthly aging of
accounts receivable and/or accounts payable in the form and at the time
furnished to the Senior Lender; (3) audited annual financial statements
containing balance sheet, statement of earnings, statement of cash flows and
notes to financial statements within ninety (90) days of the end of Parent's
fiscal year prepared by a big five accounting firm or its successor or an
accounting firm which is satisfactory to the Lender accompanied by (i) an
unqualified opinion of such firm, and (ii) a certificate from such accounting
firm, addressed to the Parent's Board of Directors, stating that in the course
of its examination, nothing came to its attention that caused it to believe that
there was any default by any Borrower in the fulfillment of or compliance with
any of the terms, covenants, provisions or conditions of this Agreement or any
other material agreement to which any Borrower is a party; (4) such additional
information, reports, budgets or statements as the Lender may from time to time
reasonably request in connection with this Agreement; and (5) permit, upon
reasonable notice, a representative of the Lender to inspect the books, records,
budgets, and documents received by the Board of Directors or properties of the
Borrowers at reasonable times and to make copies and abstracts of such books and
records and any documents relating to such properties, and to discuss the
Borrowers' affairs, finances, and accounts with its officers. Borrowers shall
also provide to Lenders within five (5) days of request all such information
required by Lenders to report to the Small Business Administration the economic
impact of Lender's loan to Borrowers. Without Lender's prior written consent,
Borrowers shall not modify or change any accounting policies or procedures in
effect on the date hereof.

         (b) Payment Of Taxes. Promptly pay all taxes, levies and assessments,
and governmental charges upon it, its income, and its properties, due to all
local, state and federal agencies. Except to the extent that a Borrower has
established a cash reserve and is actively pursuing a tax dispute or appeal, any
failure by a Borrower to promptly pay any taxes, levies and assessments due,
shall be an event of default.

         (c) Insurance. Maintain adequate fire and extended risk coverage,
business interruption, workers disability compensation, public liability,
environmental, flood, and such other insurance coverages as may be required by
law or as is customary and adequate among businesses in Borrowers' industry
engaged in the same or similar activities. All insurance policies shall be in
such amounts, upon such terms, in form, and carried with insurers with a "best
rating" of B or better or such


                                       21


<PAGE>   27

insurers as are acceptable to Lender. Each Borrower shall provide evidence
satisfactory to Lender of all insurance coverages and that the policies are in
full force and effect, and for all insurance coverages upon any property which
is collateral, the insurance policy shall be endorsed to provide Lender with a
standard loss payable clause with not less than thirty (30) days advance written
notice to Lender by the insurer of any cancellation or modification of coverage.
Any failure by a Borrower to maintain insurance as provided in this Agreement
shall be an event of default and Lender may obtain insurance, without obligation
to do so, and all amounts so expended by Lender shall be added to the
indebtedness or shall be payable on demand, at Lender's option.

         (d) Notice of Adverse Events. Promptly notify the Lender of any
actions, suits, proceedings or claims before any court, governmental department,
commission, board, bureau, agency or instrumentality, commenced or threatened
against the Borrowers involving Twenty-Five Thousand Dollars ($25,000.00) or
more or which could otherwise affect the conduct of its business.

         (e) Maintenance. Maintain, preserve, and keep its properties and
equipment, whether leased or owned, in good repair and working order and
condition, ordinary wear and tear excepted, and will from time to time make all
needed and proper repairs, renewals, replacements, additions and betterments
thereto so that at all times the efficiency thereof shall be fully preserved and
maintained, and comply with all the federal, state and local laws and
regulations including environmental law.

         (f) Board of Directors. Parent shall forward to the Lender copies of
all documents given by Parent to its board of directors and shall allow a
representative of the Lenders, designated by White Pines Management, L.L.C., to
observe the board meetings and provide the Lender with at least seven (7) days
notice (one (1) day for special meetings) prior to each and every board meeting.
Parent's board of directors must approve the Borrowers' annual operating budget
and five year Business Plan and Borrowers shall provide the Lender with a copy
of said annual operating budget and five year Business Plan as soon as available
and in no event less than five (5) days prior to the beginning of each fiscal
year.

         (g) Environmental Compliance/Notices/Indemnity. Strictly comply with
all environmental laws applicable to Borrowers' business. Borrowers agree to
notify Lender not later than ten (10) days after Borrowers' receipt, of any
summons, notice, lawsuit, citation, letter, or other advice received by a
Borrower from any Federal, State, or local agency or unit of government or other
person, which asserts that a Borrower is in violation of any environmental laws.
Borrowers agree to indemnify and hold Lender harmless from all violations by
Borrowers of any environmental laws, which indemnity shall include all costs and
expenses incurred by Lender, including actual legal fees, which

                                       22

<PAGE>   28

are related to any violation by Borrowers of any environmental laws, whether or
not the Loan has been paid at the time any such proceeding, claim, or action is
instituted against Lender.

         (h) Maintain Corporate Existence and Due Qualification. Parent shall
preserve and maintain its corporate existence and good standing in the State of
Delaware and qualify and remain qualified as a foreign corporation in each
jurisdiction in which such qualification is required. Each Subsidiary shall
preserve and maintain its corporate existence and good standing under the laws
of the jurisdiction of its incorporation.

         (i) Compliance With All Laws. Comply with all laws, rules and
regulations in effect or hereinafter promulgated by any foreign, federal, state
or local government, including without limitation all laws pertaining to
Borrowers' employees, the violation of which could have a material adverse
effect on the business of such Borrower.

         (j) Information From Senior Lender. Provide the Lender (i) within three
(3) days of receipt thereof, copies of any or all notices or information
received from the Borrowers' Senior Lender exercising, terminating or
accelerating any rights or obligations of Senior Lender or any Borrower
contained in any agreements between such parties or expressing the intention or
consideration of the Senior Lender to take any such action, and (ii) with the
financial statements furnished pursuant to Section 8(a)(1), a summary of any
written or oral requests made to the Senior Lender for any waivers, and the
response thereto received from the Senior Lender.

         (k) Reports.

               (i) Provide Lender promptly after the sending or filing thereof,
copies of all reports, proxy statements and financial statements, if any, which
Parent sends to or files with any of its security holders or any securities
exchange or the Securities and Exchange Commission or any successor agency
thereof.

               (ii) Provide Lender promptly in any event within ten (10) days
after receipt, a copy of any management letter or comparable analysis in the
event such letter or analysis is prepared by the auditors for the Borrowers.

         (1) Compliance Certificate. Provide the Lender with appropriate
certification on an annual basis that the Borrowers are in compliance with all
the terms and conditions of this Agreement and that an Event of Default pursuant
to Section 10 hereof has not occurred.

         (m) Use of Proceeds. The Borrowers shall use the proceeds of the Loan
for working capital and expenses of the transactions contemplated by this
Agreement, provided that none

                                       23


<PAGE>   29

of the proceeds of the Loan will be used to repay any existing indebtedness of
Borrowers. Borrowers shall give Lenders access to their records to confirm that
Borrowers have used the proceeds of the Loan solely for the foregoing purposes.
Without limiting the generality of the foregoing, Borrowers shall permit Lenders
to conduct a post-closing review within 90 days after the date hereof to assure
that the proceeds of the Loan were used for the intended purposes.

         (n) Compliance With ERISA. Comply in all material respects with the
Employee Retirement Income Security Act of 1974, as amended and the Internal
Revenue Code of 1986, as amended with respect to each of its federally insured
pension plans.

         (o) Patent Applications. Promptly file with appropriate governmental
authorities all applications for patents and patent rights as each Borrower in
its reasonable discretion, deems necessary or appropriate for the operation of
such Borrower's business as now conducted and proposed to be conducted.

         (p) Disclosure. No representation or warranty by Borrowers in any
statement, schedule, or certificate to be furnished to the Lender pursuant to
this Agreement or the other Loan Documents, or in connection with the
transactions contemplated hereby or thereby, will contain any untrue statement
of a material fact or will omit to state a material fact necessary to make the
statements contained herein or therein not misleading.

         (q) Reinstatement of Security Interests. Any secured indebtedness of
any Borrower other than to the Senior Lender shall require the holder of such
indebtedness to subordinate such indebtedness and the rights under any mortgage,
pledge, security interest or other collateral rights securing repayment of such
indebtedness, to the obligations of Parent to Lenders under the terms of the
Warrants immediately upon notice to Parent of the exercise of the Lender's
rights under subsection (K) of the Warrants, including without limitation, such
indebtedness as may be evidenced by Promissory Notes issued in accordance with
the provisions of subsection (L) of the Warrants. If the Security Agreement
and/or the Pledge Agreement have terminated in accordance with their respective
terms prior to notice to Borrower of the exercise of Lender's rights under
subsection (K) of the Warrants, the effectiveness of such Security Agreement and
Pledge Agreement shall automatically continue or be reinstated with respect to
all amounts payable in accordance with the terms of the Warrants immediately
upon notice to Borrower of the exercise of Lender's rights under subsection (K)
of the Warrants. In the event of continuation or reinstatement of such Security
Agreement and Pledge Agreement, Borrowers agree, within three days after demand
by Lenders (i) to execute and deliver to Lenders those documents which Lenders
determine are appropriate to further evidence (in the public records or
otherwise) such

                                       24

<PAGE>   30


continuation or reinstatement (although the failure of Borrowers to do so shall
not affect in any way the reinstatement or continuation), and (ii) to cause any
secured creditor to execute and deliver to Lenders a subordination agreement
reasonably acceptable to Lenders as required by this Section 8(q) . The
provisions of this Section 8(q) do not modify in any respect whatsoever the
rights of Lenders contained in Section 9(b) of this Agreement.

     9. NEGATIVE COVENANTS. Until the payment in full of the Notes, the
Borrowers shall not, except with the prior written consent of the Lender:

          (a) Financial Covenants.

               (i) allow consolidated Tangible Net Worth to be less than
negative $5,750,000 during 1999, to be less than negative $7,500,000 at any time
during 2000 or at any time thereafter, to be less than negative $6,500,000 as of
December 31, 2001 or at any time thereafter, to be less than negative
$2,750,000 as of December 31, 2002 or at any time thereafter, or to be less than
$1,250,000 as of December 31, 2003 or at any time thereafter, provided that each
of the foregoing amounts shall be decreased by the amount of interest paid in
cash (net of any tax savings) on additional funds, if any, loaned to the
Borrowers by Lenders pursuant to Section 1(c) of this Agreement. "Tangible Net
Worth" shall mean Net Worth less intangible assets. Intangible assets include
goodwill, patents, copyrights, development expenses, computer software, mailing
lists, trademarks, bond discount and underwriting expenses, organization
expenses, and all other intangibles.

               (ii) allow consolidated Long-Term Debt to be greater than
$15,500,000 at any time during 1999, to be greater than $16,500,000 at any time
during 2000, to be greater than $17,500,000 at any time during 2001, to be
greater than $21,500,000 at any time during 2002 or 2003, or to be greater than
$18,500,000 as of December 31, 2003 or at any time thereafter, provided that
each of the foregoing amounts shall be increased by the amount, if any, of
additional funds loaned to Borrowers by Lenders pursuant to Section 1(c) of this
Agreement. "Long-Term Debt" shall mean the sum of (x) all bank debt, (y) all
liabilities classified as long-term in accordance with generally accepted
accounting principles, and (z) the current portion of any liabilities
encompassed by "(y)"

          (b) Liens and Indebtedness. Pledge, mortgage or otherwise encumber, or
subject to or permit to exist upon or be subjected to any lien, security
interest or charge, any asset or any property of any kind or character at any
time owned by the Borrowers, except: (1) liens for taxes not yet due which are
being contested; (2) purchase money security interests incidental to the conduct
of its business, and (3) liens and encumbrances granted to Borrowers' Senior
Lender.


                                     25

<PAGE>   31



          (c) Dividends, Distributions; Capital Structure. Parent shall not
purchase or retire any of its shares without Lender's prior written consent.
Parent shall not declare any dividends on, or make any other distributions with
respect to, any shares of its capital stock or apply any of its property or
assets to the purchase, redemption, or other retirement of any shares of any
class of its capital stock, or set apart any sum for any such payments.

          (d) Stock. Except for (i) the shares issuable upon conversion of
outstanding shares of preferred stock of Parent, and (ii) the shares presently
subject to existing employee and director stock option plans, issue or sell any
additional shares of capital stock, whether common or preferred, either directly
or indirectly to any affiliate, shareholder, director, officer, employee or any
close relative thereof. "Close relative" means parent, child, sibling, spouse,
father-in-law, mother-in-law, son in-law, brother-in-law, daughter-in-law, or
sister-in-law.

          (e) Leases. Enter into any arrangement providing for the leasing by a
Borrower of any real or personal property previously owned by such Borrower if
any portion of the lease obligation does not constitute "Long-Term Debt" for
purposes of Section 9(a)(ii) hereof.

          (f) Environmental. Allow the real property owned or leased by a
Borrower to be used to store, use, or otherwise handle any hazardous or toxic
substance or other contaminants, except in the ordinary course of Borrower's
business, nor shall any Borrower allow any oil or gas tanks to be placed on any
of its real property, whether owned or leased, or any other similar activities
which might result in the raising of environmental issues regarding the
property, nor shall any Borrower handle, arrange for transport, deliver for
disposal or dispose of (directly or indirectly) any hazardous waste or hazardous
substances so as to contaminate any property or give rise to any remediation,
clean-up or damage obligation under any statute, rule, regulation, ordinance or
other common law.

          (g) Transactions With Insiders Or Related Companies. Other than
transactions between or among Parent and Subsidiaries, no Borrower shall,
directly or indirectly:

               (i) enter into any transaction, agreement or arrangement with any
shareholder, director, employee, officer or affiliate of a Borrower, or any
close relative of any shareholder, director, officer or affiliate of a Borrower,
on terms and conditions any less favorable to such Borrower than those which
could have been obtained from a party which was not such a shareholder,
director, officer or affiliate or close relative; or

                                       26


<PAGE>   32


               (ii) make any advance or loan which exceeds Ten Thousand and
00/100 ($10,000) Dollars or which extends for a period longer than one (1) year,
to any affiliate, or any shareholder, director, officer or employee thereof, or
to any close relative of the foregoing, or to any trust of which any of the
foregoing is a beneficiary, or guaranty any indebtedness for any of the
foregoing, provided that the foregoing shall not preclude the execution and
delivery by employees of their promissory notes for the purchase price of shares
of common stock upon exercise of options under the stock option plans of Parent.

          (h) Nature Of Business. Engage in any business other than those which
Borrowers currently conduct or as contemplated by the Business Plan.

          (i) Change In Management. Cause or permit Jeffrey S. Williams to cease
serving as President and Chief Executive Officer of Parent.

     10. EVENTS OF DEFAULT. The occurrence of any of the following events
which shall not be cured by Borrowers within fifteen (15) days after notice to
Borrowers from Lender of such event shall constitute an "Event of Default" under
this Agreement; provided that no such notice shall be required with respect to
subparagraph "(a)" below, Failure To Pay Amounts Due.

          (a) Failure To Pay Amounts Due. Any fees or any principal or interest
on any indebtedness to Lender is not paid within two business days of when due;

          (b) Misrepresentation; False Financial Information. Any warranty or
representation of Borrowers in connection with or contained in this Agreement,
the Loan Documents, any certificate, document or financial or other statement
now or hereafter furnished to the Lender by or on behalf of the Borrowers, is
false or misleading in any material respect.

          (c) Noncompliance With Lender Agreements. Borrowers shall fail to
perform in any material respect any of their obligations, covenants, and
agreements under this Agreement, or any other agreement with Lender, including
but not limited to the Loan Documents attached hereto as Exhibits.

          (d) Other Creditor Events. Any non-Lender indebtedness of Borrower is
declared to be due and payable prior to the stated maturity thereof or the
Senior Lender shall give a default notice or effect a standstill period under
the terms of any subordination agreement.

          (e) Judgments; Attachments; Tax Liens. There shall be entered against
a Borrower or any guarantor, any judgment which materially affects such
Borrower's or any guarantor's business, property or financial condition, or if
any tax lien, levy, attachment, forfeiture, seizure, garnishment, execution or


                                       27

<PAGE>   33


similar writ or process shall be issued against the Collateral or which
materially affects such Borrower's business, property or financial condition,
and which remains unpaid, unstayed on appeal, undischarged, unbonded, or
undismissed for a period of thirty (30) days after the date thereof.

          (f) Indictment. The institution of any criminal proceeding wherein
forfeiture of a material amount of the Borrower's property is a potential
penalty.

          (g) Business Suspension, Bankruptcy. Any Borrower or any other obligor
shall voluntarily suspend transaction of its business; shall generally not pay
debts as they mature; shall make a general assignment for the benefit of
creditors; shall file or have filed against such Borrower any reorganization or
liquidation under the Bankruptcy Code or under any other State or Federal law
for the relief of debtors, or a receiver, trustee or custodian shall be
appointed for a Borrower or any other obligor or guarantor for any portion of
such Borrower's or other obligor's or guarantor's property, which is not
discharged within thirty (30) days after filing.

          (h) Material Adverse Change. Any material adverse change in
Borrowers' business, property or financial condition has occurred or is
imminent, or if the Collateral value or Lender's rights therein are materially
impaired in any way.

          (i) Hazardous Material. Any Borrower handles, uses, stores, delivers
for disposal, disposes of, transports or arranges for the transportation of any
waste, whether hazardous or not, in any manner which is not in compliance with
applicable laws, rules, regulations, ordinances or the common law, or which
contaminates any property or gives rise to any remediation or clean-up
obligation under any law, rule, regulation, ordinance or the common law; or a
Borrower contaminates any real property owned by it or any other property, or
its real property is used to handle, treat or store, or become contaminated
(including without limitation contamination of soil, ground water and service
water located on, in or under the real property) with, pollutants or any other
substances which handling, treatment, storage or contamination may give rise to
remediation or clean up obligation with respect to its real property or the
property of others under any law, rule, regulation, ordinance or the common law;
or its real property or any property to which a Borrower delivers for disposal,
disposes of, transports or arranges for transport (directly or indirectly) any
waste is listed on the National Priority List or any state listing which
identifies sites for remedial cleanup or investigatory action.

          (j) Use Of Proceeds. Any diversion by Borrowers of the proceeds of
Lenders' Loan from the uses specified in Section 8(m) without Lenders' prior
written consent.

                                       28

<PAGE>   34


     11. REMEDIES ON DEFAULT.

          (a) Acceleration. Upon the occurrence of any Event of Default, the
Loan (with accrued interest thereon), and all other amounts owing to the Lender
under this Agreement and the Note, and all other indebtedness to Lender may, at
the option of Lender, and without demand or notice of any kind, be declared to
be immediately due and payable.

          (b) Remedies Cumulative. The remedies provided for in this Agreement
are cumulative and not exclusive, and Lender may exercise any remedies available
to it at law or in equity, and as are provided in this Agreement, the Loan
Documents, and any other agreement between any Borrower and Lender.

          (c) No Waiver. No delay or failure of Lender in exercising any right,
remedy, power or privilege hereunder shall affect that right, remedy, power or
privilege, nor shall any single or partial exercise thereof preclude the
exercise of any other right, remedy, power or privilege. No delay or failure of
Lender to demand strict adherence to the terms of this Agreement shall be deemed
to constitute a course of conduct inconsistent with the Lender's right to at any
time, before or after any Event of Default, demand strict adherence to the terms
of this Agreement and the related documents.

     12.  OTHER CONSIDERATION TO LENDERS.

          (a) Closing Fee. Upon closing the portion of the Loan provided for in
Section 1(a) hereof, Borrower shall pay to Lenders a closing fee in the amount
of $61,250. Upon closing any portion of the Loan provided for in Section 1(c)
hereof, Borrower shall pay to Lenders a closing fee equal to one and three
quarters (1-3/4%) percent of such additional amount of the Loan.

          (b) Expenses. Borrowers agree to pay on demand all out-of-pocket
expenses of the Lenders incurred in connection with making the Loan, including
the actual reasonable fees and expenses of its counsel, expenses incurred in due
diligence activities, lien searches and credit reviews, in connection with the
preparation of this Agreement and the supporting documentation, provided that
the amount of such expenses which Borrowers shall be required to reimburse shall
not exceed (i) $2,500 of expenses of Lenders, (ii) $15,000 of fees and expenses
payable to third parties by Lenders, and (iii) legal counsel fees incurred in
connection with (x) any change in the terms and provisions of the transaction as
compared to those set forth in the letter of intent dated September 23, 1999
(including any such changes or additions required by any of the "Other
Investors" referred to in the letter of intent), and (y) any changes to or
additional provisions in the April 1999 Loan Documents other than those required
as a direct consequence of the transaction contemplated by and under the terms
specified in such letter of intent.

                                       29

<PAGE>   35


          (c) Repurchase of Securities Upon Declination of Sale of Borrower. If
at any time following April 23, 2004, Borrowers or any of the shareholders,
officers, directors, employees, or agents of Parent receive a bona-fide offer
from any third party for (i) the purchase of all or substantially all of the
assets and properties of Parent, (ii) the purchase of 50% or more of the
outstanding common stock of Parent, or (iii) the merger or consolidation of
Parent with another person or persons (collectively, the "Offer"), Borrowers
shall give Lenders prompt written notice of the Offer and its terms and the
identity of the person making such Offer. Borrowers shall also advise the
Lenders whether Parent, or shareholders owning a majority of the outstanding
common stock of Parent, as the case may be, intend to accept such Offer. Within
30 days after receipt of such notice, each Lender may notify Parent that it is
requesting that Parent, or shareholders owning a majority of the outstanding
common stock of Parent, as the case may be, accept, or cause Parent to accept,
such Offer. If Parent, or shareholders owning a majority of the outstanding
common stock of Parent, as the case may be, does not accept the Offer and close
the transaction contemplated thereby, each Lender may, within 180 days after
such Offer shall have terminated or been revoked, or the transaction
contemplated thereby terminated or abandoned, give Parent written notice of
demand by such Lenders that Borrowers promptly purchase all of the Warrants or
shares of common stock issued upon exercise of the Warrants, and any other
securities of Parent acquired by Lenders pursuant to this Agreement, held by
such Lender, and Borrowers shall purchase such securities within 30 days after
the date of such demand. The consideration that the Borrowers shall pay to the
Lender for the repurchased securities shall be each Lender's prorata part of the
total consideration presented as part of the Offer, provided, however, that if
the Offer included consideration other than cash or promissory notes payable in
cash, Borrowers shall pay each Lender in cash the fair market value of each
Lender's prorata part of such non-cash consideration, with such fair market
value to be determined by an appraiser selected by Parent and acceptable, in
their sole discretion, to a majority of the Lenders who made such demand.
Borrowers shall pay the costs and fees of the appraiser.

          (d) Exchange of Securities. If at any time, or from time to time,
hereafter and prior to November 1, 2000, Parent shall issue any equity
securities having an aggregate purchase price in excess of $5,000,000 (exclusive
of any securities issued to Lenders pursuant to Section 1(c) hereof) , then
each Lender which shall not have exercised its Warrants in whole or in part, at
such Lender's sole option and discretion, shall have the right to require Parent
to issue to such Lender the type and amount of securities which would have been
issued to such Lender had the Loan of such Lender instead been a part of the
transaction, or the transaction of such Lender's choice if there was more than
one transaction, pursuant to which Parent issued such equity securities.
Concurrently with delivery to such Lender of such

                                       30

<PAGE>   36


securities, the Lender shall deliver to Parent its Note marked as "paid" and its
Warrants marked as "cancelled". Any Lender may exercise its rights under this
Section 12(d) by notice to Parent given on or prior to the latest of (i) the
closing date of the transaction as a result of which the aggregate purchase
price of equity securities issued by Parent subsequent to the date hereof
(exclusive of any securities issued to Lenders pursuant to Section 1(c) hereof)
shall first exceed $5,000,000, (ii) twenty (20) days after Parent shall have
delivered to Lenders the letter of intent, if any, relating to the proposed
transaction and a draft of the proposed definitive agreement, and (iii) five (5)
days after Parent shall have delivered to Lender (x) the final form of
definitive agreement (including all schedules and exhibits thereto) to be
executed to implement such transaction, and (y) the most recent available
financial statements of Parent.

     13. REPRESENTATIONS AND WARRANTIES OF LENDER. Each Lender represents and
warrants to Parent, only as to itself, as follows:

          (a) Investment. The Lender is acquiring the Note and Warrants for its
own account, for investment purposes, without a view to or for resale in
connection with, any distribution thereof.

          (b) Transfers. The Lender understands that since the Note, Warrants
and shares of common stock purchaseable upon exercise of the Warrants have not
been registered under the Securities Act of 1933 (the "Securities Act") or
applicable state securities laws, the Lender must bear the economic risk of an
investment in such securities for an indefinite period of time unless they are
subsequently registered under the Securities Act and applicable state securities
laws or an exemption from such registration is available. In that regard, the
Lender has been advised that:

               (i) Parent's obligations to register such securities under the
Securities Act or any Blue Sky Laws are limited as set forth in the Registration
Rights Agreement dated April 23, 1999, as amended.

               (ii) Parent is not subject to the reporting requirements of the
Securities Exchange Act of 1934, as amended, and Rule 144 is not presently
available for public release of the securities. It acknowledges that the
securities must be held indefinitely unless they are subsequently registered
under the Securities Act or an exemption from such registration is available.
It has been advised or is aware of the provisions of Rule 144 promulgated under
the Securities Act, which permits limited resale of securities purchased in a
private placement subject to the satisfaction of certain conditions.

          (c) Accredited Investor. Lender is an "Accredited Investor", as that
term is defined in Rule 501 of Regulation D promulgated under the Securities
Act.

                                       31

<PAGE>   37


          (d) Restrictive Legend. The Lender agrees that the documents
representing the securities will bear the following restrictive legend:

THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 OR
ANY STATE SECURITIES LAWS. THEY MAY NOT BE SOLD OR OFFERED FOR SALE, PLEDGED,
HYPOTHECATED OR OTHERWISE TRANSFERRED IN THE ABSENCE OF AN EFFECTIVE
REGISTRATION STATEMENT AS TO THE SECURITIES UNDER SAID ACT AND ANY APPLICABLE
STATE SECURITIES LAW OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL
SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED TO EFFECTUATE
SUCH TRANSACTION.

          (e) Sophistication. By reason of the Lender's or the Lender's offeree
representative's knowledge and experience in financial and business matters in
general, and investments of this type in particular, the Lender is capable of
evaluating the merits and risks of any investment in the Notes and Warrants.

          (f) Legal Investment. Subject to the accuracy of the representations
and warranties of Borrowers set forth in this Agreement, each Lender's purchase
of the Note and Warrants hereunder will, at the time of the Closing, be legally
permitted by all laws and regulations to which such Lender is subject.

     14. MISCELLANEOUS. The following miscellaneous provisions shall apply:

          (a) Rights Cumulative; Waivers. This Agreement and all of the
covenants, warranties, and representations of the Borrowers and all of the
powers and rights of the Lender hereunder shall be in addition to and cumulative
of all other covenants, representations, and warranties of the Borrowers, and
all other rights and powers of the Lender contained in, or provided for in, any
other instrument or document now or hereafter executed and delivered by the
Borrowers to or in favor of the Lender. No waiver or consent shall be effective
as against the Lenders unless the same is in writing and signed by Lenders
owning not less than two-thirds of the Warrants (or shares of common stock of
Parent issued upon exercise of the Warrants) issued pursuant to this Agreement.
Any waiver or consent effected in accordance with this Section 14(a), including
any waiver of an Event of Default, shall be binding upon each Lender. No such
waiver or consent shall extend to or affect any obligation or right except to
the extent expressly provided for therein.

          (b) Notices. Any and all notices provided for in this Agreement shall
be given in writing by registered or certified mail, return receipt requested
and shall be deemed to have been given when mailed, and shall be addressed as
follows:

                                       32

<PAGE>   38


As to WPLP:
White Pines Limited Partnership I
2401 Plymouth Road, Suite B
Ann Arbor, MI 48105

As to Pacific:
Pacific Capital, L.P.
2401 Plymouth Road, Suite B
Ann Arbor, MI 48105

As to Bund, Yocum, Volunteer,
Kalish, Boyle, Kantner and
   Williams
White Pines Management, L.L.C.
2401 Plymouth Road, Suite B
Ann Arbor, MI 48105

and with a copy to:

Mr. Perry M. Kantner
Kantner and Associates
661 Airport Blvd., Suite 2A
Ann Arbor, MI 48108

As to Borrowers:
Genomic Solutions, Inc.
4355 Varsity Drive, Suite E
Ann Arbor, MI 48108

As to Chase:
Chase Venture Capital
Associates, L.P.
380 Madison Avenue, 12th Floor
New York, NY 10017

As to American:
American Healthcare Fund II
4430 Arapahoe Avenue, Ste. 220
Boulder, CO 80303

As to Mackowski-CA:
J. Matthew Mackowski
275 Post Street, Suite 600
San Francisco, CA 94108

As to Shepler:
Robert G. Shepler
275 Post Street, Suite 600
San Francisco, CA 94108

As to Mackowski-FL
John J. Mackowski
1506 Birkdale Lane
Ponte Verde Beach, FL 32082

As to Grove:
Grove Investment Partners
336 Essex Road
Kenilworth, IL 60043

As to Kent:
Lawrence J. Kent
404 E. Lancaster Ave.
Wayne, PA 19087

As to JWilliams:
Jeffrey S. Williams
7049 Suncrest Drive
Saline, MI 48176

                                       33

<PAGE>   39


As to Auton:
Kevin A. Auton
42 Croftfield Road
Godmanchester
Huntingdon, Cambridgeshire
PE18 8ED

As to Jakimcius:
Andrew A. Jakimcius
1096 Heritage Drive
Saline, MI 48176

As to Kurek:
Michael P. Kurek
2720 Holyoke Lane
Ann Arbor, MI 48103

As to Richvalsky:
Steven J. Richvalsky
12215 Deer Creek Drive
Plymouth, MI 48170

          (c) Reimbursement For Expenses. Borrowers agree to pay and reimburse
the Lender upon demand for all expenses and costs paid or incurred by the Lender
of any nature, whether incurred in or out of court, and whether incurred before
or after all sums due pursuant to this Agreement shall become due, at their
maturity date or otherwise, including but not limited to reasonable actual
attorneys fees and costs, which Lender may deem necessary or proper in
connection with the administration or satisfaction of the indebtedness,
including the amending of this Agreement or the Loan Documents or providing any
consent, or waiving any provision contained herein or therein, or the
supervision, preservation, protection of (including but not limited to, the
maintenance of adequate insurance) or the realization upon the Collateral, or
incurred in any bankruptcy, arrangement, or reorganization proceeding involving
any Borrower. Any and all indebtedness owing by the Lender to the Borrowers may
at any time without notice or demand be offset and applied to any indebtedness
or liability of the Borrowers to the Lender, whether or not then due.

          (d) Binding Effect. This Agreement shall be binding upon the Borrowers
and their respective successors, and legal representatives, provided however,
that Borrowers cannot assign or transfer their rights or obligations under this
Agreement without Lender's prior written consent. This Agreement shall inure to
the benefit of the Lenders and to the benefit of their respective heirs, legal
representatives, successors and assigns including any subsequent holder or
holders of the Note, the Warrants or any interest therein.

          (e) Generally Accepted Accounting Principles. All computations and
determinations of the income, assets and

                                       34

<PAGE>   40


liabilities of the Borrowers for the purpose of this Agreement shall be made in
accordance with United States generally accepted principles of accounting
consistently applied, except as may be otherwise specifically provided herein.

          (f) No Partnership Or Joint Venture Established. Nothing contained in
this Agreement or any other Loan Document, and no action taken by the Lender
pursuant hereto or thereto shall be deemed to create a partnership, joint
venture or other entity or business relationship between the Lender and the
Borrowers except that created in a conventional commercial loan transaction. It
is acknowledged by the Borrowers that the Lender asserts no dominion or control
over the business operations of the Borrowers other than for purposes of
monitoring its business operations to protect their interest in the Collateral
as a secured creditor of the Borrowers.

          (g) Governing Law; Jurisdiction. This Agreement and the related
documents shall be interpreted and the rights of the parties determined under
the laws of the State of Michigan without regard to its conflict of law
principles. Each Borrower expressly submits to the jurisdiction and venue in the
Federal or state courts of the State of Michigan by process served by mail on
such Borrower at the address set forth above. Should any part, term or provision
of this Agreement be judged illegal or conflict with any applicable law, the
validity of the remaining portion or provisions of this Agreement shall not be
affected.

          (h) Further Action. Each Borrower agrees, from time to time, upon
Lender's request, to make, execute, acknowledge, and deliver to Lender such
further and additional instruments, documents and agreements, to take such
further action as reasonably may be required to carry out the intent and purpose
of this Agreement and repayment of the loans.

          (i) Writings Constitute Entire Agreement; Modifications Only In
Writing. This Agreement, the related documents and all other written agreements
between Borrowers and Lender, constitute the entire Agreement of the parties,
and there are no other agreements, express or implied. This Agreement supersedes
any and all commitment letters or term sheets heretofore issued in connection
with this Loan. None of the parties shall be bound by anything not expressed in
writing, and neither this Agreement, the related documents, nor any other
agreement can be modified except by a writing executed by Borrowers and by
Lenders owning not less than two-thirds of the Warrants (or shares of common
stock of Parent issued upon exercise of the Warrants) issued pursuant to this
Agreement. Any

                                       35

<PAGE>   41


modification effected in accordance with this Section 14(i) shall be binding
upon each Lender.

          (j) Survival Of Terms, Representations And Warranties. The terms and
conditions of this Agreement as well as the Representations and Warranties
contained herein shall survive the closing of this financing transaction.

          (k) Jury Trial Waivers. Each Borrower does knowingly, voluntarily and
intelligently waive its constitutional right to a trial by jury with respect to
any claim, dispute, conflict, or contention, if any, as may arise under
this Agreement or under the related documents, and agree that any litigation
between the parties concerning this Agreement and the related documents shall be
heard by a court of competent jurisdiction sitting without a jury. Each Borrower
does hereby confirm to Lender that it has reviewed the effect of this waiver of
jury trial with competent legal counsel of its choice, or been afforded the
opportunity to do so, prior to signing this Agreement and the related documents,
and each acknowledge and agree that Lender is relying upon this waiver in
extending the Loans to Borrowers.

          (1) Indemnification. Each Borrower hereby agrees to indemnify and hold
harmless the Lenders and their affiliates and their respective partners,
officers, directors, employees, agents and representatives against any loss,
liability, demand, claim, action, cause of action, cost, damage, deficiency,
tax, penalty, fine or expense (including reasonable legal and accounting fees
and expenses related thereto or incurred in enforcing this Section 14(l), but
excluding punitive damages) arising from the untruth, inaccuracy or breach of
any of the representations, warranties, covenants or agreements of the Borrowers
contained in this Agreement or any Loan Documents or any facts or circumstances
constituting any such untruth, inaccuracy or breach, or any such breach
resulting from the Borrowers' operation of its business.

          (m) Lender's Assignment. The rights of Lender and its assigns
hereunder shall not be impaired by Lender's sale, hypothecation or
rehypothecation of any Note of the Borrowers or any item of the collateral or by
any indulgence, including but not limited to (a) any renewal, extension, or
modification which Lender may grant with respect to the indebtedness or any part
thereof or (b) any surrender, compromise, release, renewal, extension, exchange
or substitution which Lender may grant in respect to the collateral, or (c) any
indulgence granted in respect of any endorser, guarantor, or surety. The
purchaser assignee, transferee or pledgee of this Agreement, the Note, the
Warrants, the Security Agreement, Subordination Agreements, Financing
Statements, Collateral, and any other document (or any of them), sold, assigned,
transferred, pledged or repledged, shall forthwith become vested with and
entitled to exercise all the powers and rights given by this Agreement as if
said

                                       36

<PAGE>   42


purchaser, assignee, transferee, or pledgee were originally named as Lender in
said documents.

          (n) Brokers. No Borrower has made any commitment or otherwise incurred
any obligation to pay any commission to any broker or finder in connection with
the transaction provided for in this Agreement.

          (o) Counsel for Certain Lenders. Each of Chase, American,
Mackowski-CA, Shepler, Mackowski-FL, Grove, Kent, JWilliams, Auton, Jakimcius,
Kurek and Richvalsky hereby confirms that it has reviewed this Agreement and the
Loan Documents with competent legal counsel of its choice, or been afforded the
opportunity to do so, prior to signing this Agreement and the related documents,
and each acknowledge and agree that such Lender is not relying upon Kantner and
Associates as its counsel in connection with this Agreement.

     15. CONSTRUCTION AND INTERPRETATION. Should any provision of this Agreement
require judicial interpretation, the parties hereto agree that the court
interpreting or construing the same shall not apply a presumption that the
terms hereof shall be more strictly construed against one party by reason of
the rule of construction that a document is to be more strictly construed
against the party that itself or through its agent prepared the same, it being
agreed that the Lenders, Borrowers and their respective agents have participated
in the preparation hereof.

     IN WITNESS WHEREOF, the parties have executed this Agreement as of the day
and year first written above.

LENDERS:                                     BORROWERS:


WHITE PINES LIMITED PARTNERSHIP I            GENOMIC SOLUTIONS, INC.
By:  White Pines G.P., L.L.C.,
     its general partner



By: /s/ Frederick L. Yocum                   By: /s/ Jeffrey S. Williams
    ----------------------------                 -----------------------
    Frederick L. Yocum, Chairman                 Jeffrey S. Williams
                                                               President
PACIFIC CAPITAL, L.P.
By:  WP Pacific G.P., L.L.C.                 GENOMIC SOLUTIONS, LTD.
     a general partner


By: /s/ Frederick L. Yocum                   By:  /s/ Jeffrey S. Williams
    ----------------------------                  -----------------------------
    Frederick L. Yocum, Chairman




<PAGE>   43


IAN R. N. BUND                               GENOMIC SOLUTIONS, K.K.
YOCUM CONSULTING ASSOCIATES, INC.
VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C.
RONALD G. KALISH LIVING TRUST U/A/D          By: Jeffrey S. Williams
   SEPTEMBER 9, 1997                             ------------------------
McDONALD INVESTMENTS INC. CUSTODIAN
   FBO DANIEL J. BOYLE IRA ROLLOVER
   ACCOUNT #85314893
KANTNER AND ASSOCIATES PROFIT SHARING
   PLAN U/A/D JANUARY 1, 1991
MICHAEL G. WILLIAMS
By:  White Pines Management, L.L.C.
     a Michigan limited liability
     company, attorney-in-fact


By:  /s/ Frederick L. Yocum
     -------------------------------
     Frederick L. Yocum Chairman

CHASE VENTURE CAPITAL ASSOCIATES, L.P.

By:  /s/ Damion Wicker
     -------------------------------

AMERICAN HEALTHCARE FUND II, L.P.

By:  Capital Health Venture Partners
     Its General Partners

By:  /s/ Dan J. Mitchell
     -------------------------------
     Dan J. Mitchell
     General Partner

/s/ J. Matthew Mackowski
------------------------------------
J. MATTHEW MACKOWSKI

/s/ Robert O. Shepler
------------------------------------
ROBERT O. SHEPLER

John J. Mackowski
------------------------------------
JOHN J. MACKOWSKI

GROVE INVESTMENT PARTNERS

By: /s/ John R. Kerr
    --------------------------------

/s/ Lawrence J. Kent
------------------------------------
LAWRENCE J. KENT

/s/ Jeffrey S. Williams
------------------------------------
JEFFREY S. WILLIAMS

/s/ Kevin A. Auton
------------------------------------
KEVIN A. AUTON

                                       37

<PAGE>   44
/s/ Andrew A. Jakimcius
--------------------------------------
ANDREW A. JAKIMCIUS


/s/ Michael P. Kurek
--------------------------------------
MICHAEL P. KUREK


/s/ Steven J. Richvalsky
--------------------------------------
STEVEN J. RICHVALSKY
<PAGE>   45
                   AMENDMENT NO. 1 TO BUSINESS LOAN AGREEMENT

         THIS AMENDMENT NO. 1 TO BUSINESS LOAN AGREEMENT is made this 28th day
of October 1999 by and among Genomic Solutions, Inc., a Delaware corporation,
4355 Varsity Drive, Suite E, Ann Arbor, Michigan 48108 (hereinafter referred to
as "Parent"), Genomic Solutions, Ltd., a United Kingdom corporation, Unit 3,
Forge Close, Little End Road, Eaton Socon, St. Neots, Cambridgshire, England
PE193TP (sometimes hereinafter referred to as "Genomic UK"), Genomic Solutions,
K.K., a Japanese corporation, Gotanda Chuo Bldg. 2F, 3-5, Higashigotanda
2--chome, Shinagawa-ku, Tokyo 141-0022, Japan (sometimes hereinafter referred to
as "Genomic Japan") (Genomic UK and Genomic Japan each sometimes hereinafter
being referred to as a "Subsidiary" and sometimes hereinafter collectively
referred to as the "Subsidiaries", and each of Parent, Genomic UK and Genomic
Japan sometimes hereinafter referred to as "Borrower", a "Borrower" or the
"Borrower" and collectively sometimes referred to as the "Borrowers"), White
Pines Limited Partnership I, a Michigan limited partnership, 2401 Plymouth Road,
Suite B, Ann Arbor, Michigan 48105 (hereinafter referred to as "WPLP"), Pacific
Capital, L.P., a Delaware limited partnership, 2401 Plymouth Road, Suite B, Ann
Arbor, Michigan 48105 (hereinafter referred to as "Pacific"), Chase Venture
Capital Associates, L.P., a California limited partnership, 380 Madison Avenue,
12th Floor, New York, New York 10017 (hereinafter referred to as "Chase"),
American Healthcare Fund II, a Delaware limited partnership, 4430 Arapahoe
Avenue, Suite 220, Boulder, Colorado 80303 (hereinafter referred to as
"American"), Ian R. N. Bund Smith Barney Prototype PS Plan Account
#206-08291-12445, P.O. Box 2022, Bloomfield Hills, Michigan 48303 (hereinafter
referred to as "Bund"), Yocum Consulting Associates, Inc., an Ohio corporation,
4622 Wyndwood Drive, Toledo, Ohio 43623 (hereinafter referred to as "Yocum"),
Volunteer Healthcare Associates, L.L.C., a Tennessee limited liability company,
6 Cadillac Drive, Suite 310, Brentwood, Tennessee 37027 (hereinafter referred to
as "Volunteer"), McDonald Investments Inc. Custodian FBO S. Sterling McMillan
III IRA Rollover Account #85362191, 2550 Som Center Road, Suite 300, Willoughby
Hills, Ohio 44094 (hereinafter referred to as "McMillan"), J. Matthew Mackowski,
275 Post Street, Suite 600, San Francisco, California 94108 (hereinafter
referred to as "Mackowski-CA"), ROBERT G. Shepler, 275 Post Street, Suite 600,
San Francisco, California 94108 (hereinafter referred to as "Shepler"), John J.
Mackowski, 1506 Birkdale Lane, Ponte Verde Beach, Florida 32082 (hereinafter
referred to as "Mackowski-FL"), Grove Investment Partners, an Illinois
partnership, 336 Essex Road, Kenilworth, Illinois 60043 (hereinafter referred to
as "Grove") Ronald G. Kalish Living Trust u/a/d September 9, 1997, 445 Grand Bay




<PAGE>   46


Drive, #1009, Key Biscayne, Florida 33149 (hereinafter referred to as "Kalish"),
Lois F. Marler, 48951 Fox Drive South, Plymouth, Michigan 48170 (hereinafter
referred to as "Marler"), McDonald Investments Inc. Custodian FBO Daniel J.
Boyle IRA Rollover Account #85314893, 2550 Som Center Road, Suite 300,
Willoughby Hills, Ohio 44094 (hereinafter referred to as "Boyle"), National City
Bank of MI/IL, Custodian FBO Herbert S. Amster IRA Rollover Account dated June
12, 1991 Account #MI-1491-00-4, 101 National City Bank, 101 S. Main Street, Ann
Arbor, Michigan 48104 (hereinafter referred to as "Amster"), Kantner and
Associates Profit Sharing Plan u/a/d January 1, 1991, 555 East William Street,
Ann Arbor, Michigan 48104 (hereinafter referred to as "Kantner") and Michael G.
Williams, 18000 Cavanaugh Lake Road, Chelsea, Michigan 48118 (hereinafter
referred to as "Williams") (WPLP, Pacific, Chase, American, Bund, Yocum,
Volunteer, McMillan, Mackowski-CA, Shepler, Mackowski-FL, Grove, Kalish, Marler,
Boyle, Amster, Kantner and Williams each being sometimes hereinafter referred to
as "Lender", a "Lender" or the "Lender" and collectively as "Lenders").

                                    RECITALS

     1.   Borrowers and Lenders entered into the Business Loan Agreement dated
April 23, 1999 (hereinafter referred to as the "Agreement").

     2.   Borrowers, certain Lenders and others are entering into a Business
Loan Agreement of even date herewith (hereinafter referred to as the "October
1999 Loan Agreement").

     3.   All capitalized terms used herein not otherwise defined shall have the
meanings set forth in the Agreement or the October 1999 Loan Agreement.

     4.   Borrowers and Lenders wish to amend the Agreement solely in the
respects hereinafter expressly set forth.

     NOW THEREFORE, in consideration of the original execution of the Agreement
and of the mutual covenants and agreements hereinafter set forth, Borrowers and
Lenders agree that the Agreement is hereby amended in the following respects:

     1.   Lenders acknowledge that the requirements of Section 3(d) of the
Agreement have been satisfied such that no amendment of the Warrants shall be
made provided that:

          a)   Parent shall continue to use its best efforts to obtain from the
holder of the Series M Preferred Stock a


                                       2


<PAGE>   47




declaration that the shares of common stock described in subsection G(i) of the
Warrants are "Excluded Stock" for purposes of determining whether any adjustment
shall be made to the conversion price of the Series M Preferred Stock by reason
of the issuance of additional securities of Parent, and

          b)  if such declaration is not obtained from the holder of the shares
of Series M Preferred Stock, then any additional shares of common stock of
Parent issued to the holder of the Series M Preferred Stock upon conversion
thereof by reason of an adjustment to the conversion price of the Series M
Preferred Stock resulting from the issuance of any of the additional
securities of Parent described in subsection G(i) of the Warrants shall be
considered "Additional Shares of Common Stock" issued without consideration
for purposes of subsection F of the Warrants.

     2.   Section 9(a) is hereby amended to read in its entirety
as follows:

          (a)  Financial Covenants.

                 (i)   allow consolidated Tangible Net Worth to be less than
negative $5,750,000 during 1999, to be less than negative $7,500,000 at any time
during 2000 or at any time thereafter, to be less than negative $6,500,000 as of
December 31, 2001 or at any time thereafter, to be less than negative $2,750,000
as of December 31, 2002 or at any time thereafter, or to be less than $1,250,000
as of December 31, 2003 or at any time thereafter, provided that each of the
foregoing amounts shall be decreased by the amount of interest paid in cash (net
of any tax savings) on additional funds, if any, loaned to the Borrowers
pursuant to Section l(c) of the October 1999 Loan Agreement. "Tangible Net
Worth" shall mean Net Worth less intangible assets. Intangible assets include
goodwill, patents, copyrights, development expenses, computer software, mailing
lists, trademarks, bond discount and underwriting expenses, organization
expenses, and all other intangibles.

                 (ii)   allow consolidated Long-Term Debt to be greater than
$15,500,000 at any time during 1999, to be greater than $16,500,000 at any time
during 2000, to be greater than 17,500,000 at any time during 2001, to be
greater than $21,500,000 at any time during 2002 or 2003, or to be greater than
$18,500,000 as of December 31, 2003 or at any time thereafter, provided that
each of the foregoing amounts shall be increased by the amount, if any, of
additional funds loaned to Borrowers pursuant to Section l(c) of the October
1999 Loan Agreement. "Long-Term Debt" shall mean the sum of (x) all bank





                                       3

<PAGE>   48



debt, (y) all liabilities classified as long-term in accordance with generally
accepted accounting principles, and (z) the current portion of any liabilities
encompassed by "(y)".

     3.   The following is hereby added as a new Section 12(d) to the Agreement:

          (d)   Exchange of Securities. If at any time, or from time to time,
hereafter and prior to November 1, 2000, Parent shall issue any equity
securities having an aggregate purchase price in excess of $5,000,000 (exclusive
of any securities issued to the parties to the October 1999 Loan Agreement
pursuant to Section l(c) thereof), then each Lender which shall not have
exercised its Warrants in whole or in part, at such Lender's sole option and
discretion, shall have the right to require Parent to issue to such Lender the
type and amount of securities which would have been issued to such Lender had
the Loan of such Lender instead been a part of the transaction, or the
transaction of such Lender's choice if there was more than one transaction,
pursuant to which Parent issued such equity securities. Concurrently with
delivery to such Lender of such securities, the Lender shall deliver to Parent
its Note marked as "paid" and its Warrants marked as "cancelled". Any Lender may
exercise its rights under this Section 12(d) by notice to Parent given on or
prior to the latest of (i) the closing date of the transaction as a result of
which the aggregate purchase price of equity securities issued by Parent
subsequent to the date hereof (exclusive of any securities issued to the parties
to the October 1999 Loan Agreement pursuant to Section l(c) thereof) shall first
exceed $5,000,000, (ii) twenty (20) days after Parent shall have delivered to
Lenders the letter of intent, if any, relating to the proposed transaction and a
draft of the proposed definitive agreement, and (iii) five (5) days after
Parent shall have delivered to Lender (x) the final form of definitive agreement
(including all schedules and exhibits thereto) to be executed to implement such
transaction, and (y) the most recent available financial statements of Parent.

     4.   The date "February 28, 1998" which appears in Section 7(i)(a)(ii) of
the Agreement is hereby corrected to be "February 28, 1999".

     5. Except as expressly set forth herein, the Agreement remains in full
force and effect and shall not be affected in any manner whatsoever by this
Amendment No. 1.


                                       4


<PAGE>   49


     IN WITNESS WHEREOF, the parties have executed this Amendment No. 1 to
Business Loan Agreement as of the day and year first written above.

LENDERS:                                   BORROWERS:


WHITE PINES LIMITED PARTNERSHIP I          GENOMIC SOLUTIONS, INC.
By: White Pines G.P., L.L.C.,
    its general partner


By: Frederick L. Yocum                     By: Jeffrey S. Williams
   ------------------------------             -----------------------------
   Frederick L. Yocum, Chairman               Jeffrey S. Williams
                                              President



PACIFIC CAPITAL, L.P.                      GENOMIC SOLUTIONS, LTD.
By:  WP Pacific G.P., L.L.C.,
     a general partner


By: Frederick L. Yocum                     By: Jeffrey S. Williams
   ------------------------------             -----------------------------
   Frederick L. Yocum, Chairman


IAN R. N. BUND SMITH BARNEY
   PROTOTYPE PS PLAN ACCOUNT
   #206-08291-12445                        GENOMIC SOLUTIONS, K.K.
YOCUM CONSULTING ASSOCIATES, INC.
VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C
MCDONALD INVESTMENTS INC. CUSTODIAN
      FBO S. STERLING MCMILLAN III IRA
      ROLLOVER ACCOUNT #85362191           By: Jeffrey S. Williams
RONALD G. KALISH LIVING TRUST U/A/D           -----------------------------
   SEPTEMBER 9, 1997
LOIS F. MARLER
MCDONALD INVESTMENTS INC. CUSTODIAN
   FBO DANIEL J. BOYLE IRA
   ROLLOVER ACCOUNT #85314893
NATIONAL CITY BANK OF MI/IL CUSTODIAN
   FBO HERBERT S. AMSTER IRA
   ROLLOVER ACCOUNT DATED JUNE 12, 1991
   #MI-1491-00-4
KANTNER AND ASSOCIATES PROFIT SHARING
   PLAN U/A/D JANUARY 1, 1991
MICHAEL G. WILLIAMS

By: White Pines Management, L.L.C.,
    a Michigan limited liability
    company, attorney-in-fact

By: Frederick L. Yocum
   ------------------------------
   Frederick L. Yocum, Chairman




                                       5


<PAGE>   50



CHASE VENTURE CAPITAL ASSOCIATES, L.P.


By:/s/ Damian E. Wicker
   --------------------------------

AMERICAN HEALTHCARE FUND II, LP

By:Capital Health Venture Partners
   Its General Partner
   /s/ Dan J. Mitchell
   --------------------------------
   Dan J. Mitchell
   General Partner

/s/ J. Matthew Mackowski
-----------------------------------
J. MATTHEW MACKOWSKI

/s/ Robert G. Shepler
-----------------------------------
ROBERT G. SHEPLER

/s/ John J. Mackowski
-----------------------------------
JOHN J. MACKOWSKI

GROVE INVESTMENT PARTNERS

By:/s/ John K. Kerr
   --------------------------------


















<PAGE>   51
                                                                  Attachments to
                                                                  Exhibit 10.4




Ex-10.4 Additional information to Business Loan Agreement among Genomic
        Solutions and certain of it's Warrantholders, dated October 28, 1999
<PAGE>   52
                                   EXHIBIT A

                                PROMISSORY NOTE




<PAGE>   53




THE RIGHTS OF THE HOLDER OF THIS NOTE TO RECEIVE PAYMENT ARE SUBJECT AND
SUBORDINATE TO THE PAYMENT OF ALL OBLIGATIONS OF MAKER OR OBLIGOR TO COMERICA
BANK, AND ITS SUCCESSORS AND ASSIGNS, UNDER THE TERMS OF THE SUBORDINATION
AGREEMENT DATED OCTOBER 28, 1999 EXECUTED BY GENOMIC SOLUTIONS, INC., THE PAYEE
OF THIS NOTE, ET AL.

THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 OR
ANY STATE SECURITIES LAWS. THEY MAY NOT BE SOLD OR OFFERED FOR SALE, PLEDGED,
HYPOTHECATED OR OTHERWISE TRANSFERRED IN THE ABSENCE OF AN EFFECTIVE
REGISTRATION STATEMENT AS TO THE SECURITIES UNDER SAID ACT AND ANY APPLICABLE
STATE SECURITIES LAW OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL
SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED TO EFFECTUATE
SUCH TRANSACTION.

                           P R O M I S S O R Y  N O T E

$                                                            Ann Arbor, Michigan
                                                             October 28, 1999

     FOR VALUE RECEIVED, Genomic Solutions, Inc., a Delaware corporation, 4355
Varsity Drive, Suite E, Ann Arbor, Michigan 48108, Genomic Solutions, Ltd., a
United Kingdom corporation, Unit 3, Forge Close, Little End Road, Eaton Socon,
St. Neots, Cambridgeshire, England PE193TP and Genomic Solutions, K.K., a
Japanese corporation, Gotanda Chuo Bldg. 2F, 3-5, Higashigotanda 2-chome,
Shinagawa-ku, Tokyo 141-0022, Japan, jointly and severally, hereinafter
collectively referred to as "Borrower", promise to pay to the order of       ,
hereinafter called the "Lender," or holder the sum of      ($     ) dollars in
lawful money of the United States of America, with interest at the rate of
percent (12.0%) per annum on all sums at any time unpaid, at    or at such
other place as the holder hereof may designate by written notice to the
Borrower, with interest from the date of the disbursement of the loan, until
paid.

     The principal and interest shall be payable over five (5) years ("Loan
Term") as follows: except as otherwise provided herein for early payment, the
principal shall be due and payable on the earliest of (i) October 28, 2004, (ii)
the settlement date following the effective date of a registration statement
filed by Genomic Solutions, Inc. (hereinafter sometimes referred to as "Parent")
with the Securities and Exchange Commission for a public offering and sale of
securities of Parent, (iii) the effective date, immediately after the effective
time, of any merger or consolidation of Parent, (iv) a transfer of more than





<PAGE>   54




50% of the issued and outstanding common stock of Parent (if immediately after
the transfer the transferee has control of Parent), or (v) a sale of
substantially all of the assets of Parent. Interest shall be payable quarterly
in arrears on each March 31, June 30, September 30 and December 31 commencing
December 31, 1999. On each interest payment date, (i) 7/12ths of the interest
payable on such date shall be paid in cash, and (ii) 5/12ths of the interest
payable on such date shall be paid by the issuance to Lender of a number of
shares of common stock of Parent equal to the amount of such interest divided by
the Minimum Company Value, provided that on each scheduled interest payment
date, Lender may upon ten (10) days' prior written notice to Parent elect not to
receive such payment in shares of common stock of Parent and instead elect to
defer payment of 5/12ths of the interest due on such scheduled interest payment
date, which amount shall then be added to the outstanding principal balance of
this Note with effect as of such payment date. Except as otherwise provided
herein for early or accelerated payment, the entire unpaid principal balance
plus accrued interest and all other indebtedness shall be due and payable on or
before October 28, 2004. Interest shall be calculated on a 365 day basis on the
unpaid principal balance for the actual days outstanding. For purposes of the
foregoing, "Minimum Company Value" shall be the same amount determined as the
Minimum Company Value in accordance with the provisions of the Warrants attached
to the Loan Agreement (defined below) as Exhibit B (initially $4.50 per share).

     Parent has granted to Lender a security interest in or lien upon all assets
of Parent as described in the Security Agreement and Assignment and Pledge
Agreement of even date herewith, and Borrower may hereafter grant a security
interest in or lien upon other assets as may be described in any other security
agreement, mortgage, or other document executed at any time by the Borrower and
delivered to the Lender (herein collectively termed "Collateral") as security
for the payment of this Note, and for the payment of all other liabilities,
whether direct, indirect, absolute or contingent, now or hereafter existing, due
to become due, several or otherwise, of the Borrower to the Lender under the
Loan Documents (as defined in the Loan Agreement) (herein termed
"Indebtedness").

     Upon an event of default under any security agreement, the Business Loan
Agreement dated October 28, 1999 between Lender, Borrower and others (the "Loan
Agreement"), or any document given in connection with the Collateral, which
event of default is not cured within any applicable grace period, (i) this Note
and all Indebtedness shall, at the option of the Lender, become immediately due
and payable in full without notice, presentation or demand for payment, all such
being hereby waived by the Borrower and in such event, it is agreed that the
Lender may exercise all rights and remedies available to it under any security
agreement, hypothecation agreement, Loan Agreement, or other agreement relating
to or otherwise securing any of the



                                        2


<PAGE>   55


Indebtedness or, which may be available to Lender under the Uniform Commercial
Code as in effect in the State of Michigan or other applicable law, and (ii)
this Note shall thereafter bear interest at the rate of sixteen percent (16%)
per annum until such default is cured. Delay or forbearance by the Lender in the
exercise of any right granted hereunder shall not operate as a waiver thereof.

     A late payment fee in the amount of five percent (5.0%) of the installment
due and owing will be assessed against the Borrower in the event the payment
required hereunder is received by the Lender more than ten (10) days after the
due date.

     Provided that all interest payments on this Note shall then be current,
Borrower may prepay this Note in whole at any time or in part from time to time.
Upon any payment of the principal of this Note in whole or in part prior to
October  , 2004, including as a result of this Note becoming immediately due and
payable at the option of the Lender in accordance with the terms of this Note,
Borrower shall pay a premium equal to the following sums:

     (i) on amounts prepaid prior to October 29, 2000 - five percent (5%) of
amounts prepaid;

     (ii) on amounts prepaid after October 28, 2000 but prior to October 29,
2001, four percent (4%) of amounts prepaid;

     (iii) on amounts prepaid after October 28, 2001 but prior to October 29,
2002, three percent (3%) of amounts prepaid;

     (iv) on amounts prepaid after October 28, 2002 but prior to October 29,
2003, two percent (2%) of amounts prepaid;

     (v) on amounts prepaid after October 28, 2003, one percent (1%) of amounts
prepaid,

provided however that (x) if such payment of this Note is a condition imposed by
parties purchasing not less than $10,000,000 of common stock or preferred stock
of Parent, the premium payable upon payment of this Note in whole or in part
prior to October 29, 2000 shall be 2-1/2% instead of 5%, and (y) no premium
shall be payable if the value of Borrower, implicit in the price at which shares
of common stock of Parent are sold in a public offering pursuant to a
registration statement, or the price applicable in any merger or consolidation
of Parent or the transfer of more than 50% of the issued and outstanding common
stock of Parent or the sale of substantially all of the assets of Parent, shall
exceed $50,000,000, and if the prepayment of this Note shall occur by reason of
such event. This Note is one of various promissory notes executed and delivered
by Borrower pursuant to the Loan Agreement. Borrower shall not prepay this Note
in whole or in part unless Borrower shall concurrently prepay in whole or a
prorata part of all other promissory notes


                                       3


<PAGE>   56




originally executed and delivered by Borrower on the same date as this Note.

     Notwithstanding any provision to the contrary, it is the intent of the
Lender and Borrower that neither the Lender nor any subsequent holder shall be
entitled to receive, collect, reserve or apply, as interest, any amount in
excess of the maximum lawful rate of interest permitted to be charged by
applicable law or regulations, as amended or enacted from time to time. In the
event the Note calls for an interest payment that exceeds the maximum lawful
rate of interest then applicable, such interest shall not be received,
collected, charged, or reserved until such time as that interest, together with
all other interest then payable, falls within the applicable maximum lawful rate
of interest. In the event the Lender, or any subsequent holder, receives any
such interest in excess of the then maximum lawful rate of interest, such amount
which would be excessive interest shall be deemed a partial prepayment of
principal and treated hereunder as such, or, if the principal indebtedness
evidenced hereby is paid in full, any remaining excess funds shall immediately
be paid to the Borrower.

     Borrower hereby waives presentment, demand, protest and notice of dishonor
and agrees that Borrower shall not be released or discharged by reason of any
release, sale or non-action with respect to the Collateral or other undertakings
securing this Note.

     The security rights of Lender and its assigns shall not be impaired by
Lender's sale, hypothecation, or rehypothecation of any Note of the Borrower or
any item of the Collateral, or by any indulgence, including but not limited to:
(i) Any renewal, extension, or modification which Lender may grant with respect
to the Indebtedness or any part thereof, (ii) Any surrender, compromise,
release, renewal, extension, exchange, or substitution which Lender may grant in
respect to the Collateral, or (iii) any indulgence granted in respect of any
endorser, co-maker, guarantor or surety. The purchaser, assignee, transferee, or
pledgee of this Note, the Collateral, any guarantee, and any other document (or
any of them), sold, assigned, transferred, pledged, or repledged, shall
forthwith become vested with and entitled to exercise all the powers and rights
given by this Note and all Loan Documents of the undersigned to Lender, as if
said purchaser, assignee, transferee, or pledgee were originally named as payee
in this Note and in the Loan Documents.

     This Note shall be construed, interpreted and enforced in accordance with
the laws of the State of Michigan without regard to its conflict of laws
principles. Borrower expressly submits to the jurisdiction and venue in the
Federal or state courts of the State of Michigan by process served by mail on
Borrower at the address set forth above.


                                       4


<PAGE>   57




     This Note has been negotiated between Borrower and Lender and shall be
deemed to be mutually drafted by them.

     IN WITNESS WHEREOF, this Note has been executed by the duly authorized
officers of the Borrower.

                                        GENOMIC SOLUTIONS, INC.

                                        By:
                                           -------------------------------------
                                           Jeffrey S. Williams, President

                                        GENOMIC SOLUTIONS, LTD

                                        By:
                                           -------------------------------------
                                        GENOMIC SOLUTIONS, K.K.

                                        By:
                                           -------------------------------------

<PAGE>   58



                                 EXHIBIT B has
                                 been filed as
                          Exhibit 4.13, 4.14 and 4.15


<PAGE>   59




                                   EXHIBIT C

                               SECURITY AGREEMENT


<PAGE>   60




                               SECURITY AGREEMENT

     This Security Agreement is entered into this 28th day of October, 1999, by
Genomic Solutions, Inc., a Delaware corporation, 4355 Varsity Drive, Suite E,
Ann Arbor, Michigan 48108 ("Borrower") in favor of White Pines Limited
Partnership I, a Michigan limited partnership, 2401 Plymouth Road, Suite B, Ann
Arbor, Michigan 48105 (hereinafter referred to as "WPLP"), Pacific Capital,
L.P., a Delaware limited partnership, 2401 Plymouth Road, Suite B, Ann Arbor,
Michigan 48105 (hereinafter referred to as "Pacific"), Chase Venture Capital
Associates, L.P., a California limited partnership, 380 Madison Avenue, 12th
Floor, New York, New York 10017 (hereinafter referred to as "Chase"), American
Healthcare Fund II, a Delaware limited partnership, 4430 Arapahoe Avenue, Suite
220, Boulder, Colorado 80303 (hereinafter referred to as "American"), Ian R. N.
Bund, 2401 Plymouth Road, Suite B, Ann Arbor, Michigan 48105 (hereinafter
referred to as "Bund"), Yocum Consulting Associates, Inc., an Ohio corporation,
4622 Wyndwood Drive, Toledo, Ohio 43623 (hereinafter referred to as "Yocum"),
Volunteer Healthcare Associates, L.L.C., a Tennessee limited liability company,
6 Cadillac Drive, Suite 310, Brentwood, Tennessee 37027 (hereinafter referred to
as "Volunteer"), J. Matthew Mackowski, 275 Post Street, Suite 600, San
Francisco, California 94108 (hereinafter referred to as "Mackowski-CA"), Robert
G. Shepler, 275 Post Street, Suite 600, San Francisco, California 94108
(hereinafter referred to as "Shepler"), John J. Mackowski, 1506 Birkdale Lane,
Ponte Verde Beach, Florida 32082 (hereinafter referred to as "Mackowski-FL"),
Grove Investment Partners, an Illinois partnership, 336 Essex Road, Kenilworth,
Illinois 60043 (hereinafter referred to as "Grove") Ronald G. Kalish Living
Trust u/a/d September 9, 1997, 445 Grand Bay Drive, #1009, Key Biscayne, Florida
33149 (hereinafter referred to as "Kalish"), McDonald Investments Inc.
Custodian FBO Daniel J. Boyle IRA Rollover Account #85314893, 2550 Som Center
Road, Suite 300, Willoughby Hills, Ohio 44094 (hereinafter referred to as
"Boyle"), Kantner and Associates Profit Sharing Plan u/a/d January 1, 1991, 661
Airport Blvd., Suite 2A, Ann Arbor, Michigan 48108 (hereinafter referred to as
"Kantner"), Michael G. Williams, 18000 Cavanaugh Lake Road, Chelsea, Michigan
48118 (hereinafter referred to as "Williams"), Lawrence J. Kent, 404 E.
Lancaster Ave., Wayne, Pennsylvania 19087 (hereinafter referred to as "Kent"),
Jeffrey S. Williams, 7049 Suncrest Drive, Saline, Michigan 48176 (hereinafter
referred to as "JWilliams"), Kevin A. Auton, 42 Croftfield Road, Godmanchester,
Huntingdon, Cambridgeshire PE18 8ED (hereinafter referred to as "Auton"), Andrew
A. Jakimcius, 1096 Heritage Drive, Saline, Michigan 48176 (hereinafter
"Jakimcius"), Michael P. Kurek, 2720 Holyoke Lane, Ann Arbor, Michigan 48103
(hereinafter referred to as "Kurek") and Steven J. Richvalsky, 12215 Deer Creek
Circle, Plymouth, Michigan 48170 (hereinafter referred to as "Richvalsky")
(WPLP, Pacific, Chase, American, Bund, Yocum, Volunteer, Mackowski-CA, Shepler,
Mackowski-FL, Grove, Kalish, Boyle, Kantner, Williams, Kent, JWilliams, Auton,
Jakimcius, Kurek and Richvalsky each


                                       1

<PAGE>   61




being sometimes hereinafter referred to as "Lender", a "Lender" or the "Lender"
and collectively as "Lenders").

     For value received, the Borrower hereby grants to each Lender a security
interest in and to all of the Borrower's tangible and intangible real and
personal property and fixtures, whether now owned or hereafter acquired,
including, but not limited to, goods, documents, inventory, work in process,
instruments, equipment, furniture, machinery, fixtures, trade fixtures, contract
rights, chattel paper, accounts receivable, documents, patents, licenses and
motor vehicles, together with the proceeds from the sale or other disposition
thereof and the products thereof (the "Collateral"). The Collateral shall be
considered to be all of the assets of the Borrower. The Borrower hereby pledges,
assigns, transfers and grants to the Lender a security interest in the
Collateral to secure the payment of all loans, advances, and extensions of
credit from the Lender to the Borrower, including all renewals and extensions
thereof and any and all obligations of every kind whatsoever, whether now, or
hereafter existing or arising between the Lender and the Borrower and howsoever
incurred or evidenced, whether primary, secondary, contingent, or otherwise,
under or in connection with (1) the Borrower's Notes of even date herewith in
the aggregate amount of three million five hundred thousand and no/100
($3,500,000) dollars to the Lenders, payable as to principal and interest as
provided in the Notes; (2) future advances by the Lender to the Borrower, if
any, pursuant to Section 1(c) of the Business Loan Agreement of even date
herewith; (3) all costs and expenditures made or incurred by the Lender for
taxes, insurance, and repairs to and maintenance of the Collateral or made or
incurred by Lender in the disbursement, administration, collection or
enforcement of the Notes; and (4) all liabilities of Borrower to Lender now
existing or incurred in the future, matured or unmatured, direct or contingent,
and any renewals, extensions, and substitutions of those liabilities, and any
other obligations of the Borrower, under the Business Loan Agreement and Loan
Documents (as defined therein) of Borrower of even date herewith. The foregoing
obligations shall be hereafter collectively called the "liabilities" and shall
also include all interest, costs, expenses, and reasonable actual attorneys fees
accruing to or incurred by the Lender.

     The Borrower hereby warrants, covenants and agrees as follows:

     1.  Warranties. The Borrower warrants the following:

        (a) except as provided in the Business Loan Agreement, it has or will
acquire free and clear title to all of the Collateral and the security interest
granted to Lender shall be a first security interest, and the Borrower will
defend same to the Lender against the claims and demands of all persons;




                                       2
<PAGE>   62




             (b) the Borrower will fully cooperate in placing or maintaining
Lender's lien or security interest;

             (c) all of the collateral is located in the states of Michigan or
Massachusetts;

             (d) all accounts are genuine and collectible except to the extent
of reserves provided on the balance sheet;

             (e) the Borrower will not remove or change the location of any
Collateral without the Lender's prior written consent;

             (f) the Borrower will not use the Collateral or permit it to be
used for any unlawful purpose;

             (g) the Borrower will not conduct business under any name other
than that stated herein, nor change, nor reorganize the type of business entity
as described, except upon the prior written approval of the Lender, in which
event the Borrower agrees to execute any documentation of whatsoever character
or nature demanded by the Lender for filing or recording, at the Borrower's
expense, before such change occurs;

             (h) the Borrower will keep all records of account, documents,
evidence of title, and all other documentation regarding its business and the
Collateral at the address specified herein, unless notice thereof is given to
the Lender at least ten (10) days prior to the change of any address for the
keeping of such records; the Borrower will, at all times, maintain the
Collateral in good condition and repair, ordinary wear and tear excepted, and
will not sell or remove same except as to inventory in the ordinary course of
business;

             (i) the Borrower is a legally created business entity, as described
before, and it has the power, and the person signing is duly authorized, to
enter into this Agreement; the execution of this Agreement will not create any
breach of any provision of any other agreement to which Borrower is a party; and

             (j) all Financial Statements delivered by the Borrower to the
Lender to obtain loans and extensions of credit taken as a whole (A) fairly
present in all material respects (subject, in the case of the interim financial
statements, to normal, recurring year-end adjustments which are not material
individually or in the aggregate) the financial position of the Borrower as of
the dates indicated and the results of operations of the Borrower for the
periods indicated, (B) (x) have been prepared in accordance with Generally
Accepted Accounting Principles ("GAAP") consistently applied throughout the
periods covered thereby (subject, in the case of the interim financial
statements, to normal, recurring year-end adjustments which are not material
individually or in the aggregate) or (y) to the






                                       3


<PAGE>   63




extent not prepared in accordance with GAAP, then footnotes to the Financial
Statements will be provided describing in reasonable detail the differences, if
any, between the accounting principles pursuant to which such Financial
Statements were in fact prepared and GAAP and (C) are in accordance with the
books and records of the Borrower which have been maintained in a manner
consistent with historical practice.

             2. Insurance. Borrower shall maintain adequate fire and extended
risk coverage, business interruption, workers disability compensation, public
liability, environmental, flood, and such other insurance coverages as may be
required by law or as is customary and adequate among businesses in Borrowers'
industry engaged in the same or similar activities. All insurance policies shall
be in such amounts, upon such terms, in form, and carried with insurers with a
"best rating" of B or better or such insurers as are acceptable to Lender. Each
Borrower shall provide evidence satisfactory to Lender of all insurance
coverages and that the policies are in full force and effect, and for all
insurance coverages upon any property which is collateral, the insurance policy
shall be endorsed to provide Lender with a standard loss payable clause with not
less than thirty (30) days advance written notice to Lender by the insurer of
any cancellation or modification of coverage. Said proceeds may be utilized to
restore or replace the collateral with Lender's consent, which consent will not
be unreasonably withheld, provided Borrower is not in default other than a
default arising from the loss of or damage to collateral. In the event of
default or if said proceeds are not utilized to restore or replace the
collateral, Lender may apply such proceeds as it may receive toward the payment
of the liabilities in such order as the Lender may at its sole discretion
determine. If the Borrower at any time fails to obtain or to maintain any of
the insurance required above or pay any premium in whole or in part relating
thereto, the Lender, without waiving any default hereunder, may make such
payment or obtain such policies as the Lender, in its sole discretion, deems
advisable to protect the Borrower's property. All costs incurred by the Lender,
including reasonable attorney's fees, court costs, expenses, and other charges
thereby incurred, shall become a part of the liabilities and shall be payable on
demand.

             3. Taxes, Liens, etc. The Borrower agrees to pay all taxes, levies,
judgments, assessments, and charges of any nature whatsoever relating to the
Collateral or to the Borrower's business. Except to the extent that Borrower
has established a cash reserve and is actively pursuing a tax appeal, if the
Borrower fails to pay such taxes or other charges in accordance with the
foregoing, the Lender at its sole discretion, may pay such charges on behalf of
the Borrower; and all sums so dispensed by the Lender, including reasonable
actual attorney's fees, court costs, expenses, and other charges relating
thereto, shall become a part of the liabilities and shall be payable on demand.





                                       4


<PAGE>   64




             4.  Information and Reporting. The Borrower agrees to supply to the
Lender such information concerning the status of any of its assets as the
Lender, from time to time, may reasonably request. The Borrower further agrees
to permit the Lender, its employees, and agents to have access to the Collateral
for the purpose of inspecting it, together with all of the Borrower's other
physical assets if any, and to permit the Lender, from time to time, to verify
accounts as well as to inspect, copy, and to examine the books, records, and
files of the Borrower.

             5.  Accounts. The Borrower acknowledges that Lender has a security
interest in Accounts. It is understood that the Lender will initially permit the
Borrower to collect accounts from its debtors. The Borrower understands that
this privilege may be terminated by the Lender only after an event of default
under the Business Loan Agreement or the Notes, Warrants or this Agreement shall
occur and is not cured within any applicable grace period, and that, in such
event:

                 (a) the Lender shall be vested with all of the rights of the
Borrower in respect thereto, including the right of stoppage in transit, the
ability to notify any debtor or debtors of the assignment, and the ability to
execute any instrument on behalf of the Borrower in settlement or fulfillment of
an account;

                 (b) the Borrower agrees to execute such assignments as the
Lender may request to evidence the assignment and, in the event of an assignment
to the Lender, Borrower thereafter receives payment on any account as the agent
of the Lender, and the Borrower agrees to transmit such payment in the form in
which it was received to the Lender on the date of receipt thereof,
appropriately endorsed, if necessary, to permit negotiation by the Lender;

                 (c) until such remittance, the Borrower agrees to keep all such
receipts on account separate and apart from the Borrower's own funds so that
such receipts are readily identifiable as the property of the Lender and to hold
same in trust for the Lender; and

                 (d) in any event, the Lender is authorized to endorse or to
sign, in the name of the borrower, any instrument of whatsoever nature to effect
the collection of the accounts for application to the liabilities.

             6. Default. A default by the Borrower under the Business Loan
Agreement, the Notes, the Warrants or any other agreement entered into between
the Borrower and the Lender, which default is not cured within any applicable
grace period, shall constitute a default of this Security Agreement. The
covenants, conditions, events of default and other terms set forth or referred
to in any and all documents entered into between the






                                       5


<PAGE>   65




Borrower and Lender are incorporated into this Security Agreement with the same
force and effect as if those such covenants, conditions, and events of default
were fully set forth herein.

             7. Remedy.  The Borrower agrees that, whenever a default exists,
Lender shall have the remedies set forth in the Business Loan Agreement and
Lender may exercise, from time to time, any rights and remedies, including the
right to immediate possession of the Collateral, available to it under
applicable law. The lender shall have the right to hold any property then in or
upon said Collateral at the time of repossession not covered by the security
agreement until return is demanded in writing by the Borrower or other party
entitled thereto. The Borrower agrees, in the case of default, to assemble, at
its own expense, all Collateral at a convenient place acceptable to the Lender
and to pay all reasonable costs of the Lender in connection with the collecting
of the liabilities and enforcement of any rights hereunder, including reasonable
attorney's fees and legal expenses, and including participation in Bankruptcy
proceedings; and to pay all of the expense of locating the collateral, as well
as the expense of any repairs for any realty or other property to which any of
the Collateral may have been affixed or made a part. Any notification of
intended disposition of the Collateral by the Lender shall be deemed to be
reasonable and proper if sent postage prepaid, by regular mail, to the Borrower
at least seven (7) days before such disposition, and addressed to the Borrower
either at the address shown herein or at any other address. The Lender shall, in
the event of any default have the right to peacefully retake any of the goods.
In the event of a default, the Borrower expressly authorizes the Lender to
offset any debts of the Lender to the Borrower against the Liabilities.

             8. Termination.  This Agreement and related financing statements
shall be terminated upon payment in full of the aforementioned Notes and all
other sums and expenses required to be paid pursuant to the terms of the
Business Loan Agreement, the Loan Documents other than the Warrants, and the
Warrants but only if prior to the time such termination would otherwise occur
Borrower has been notified of the exercise of Lenders' rights under subsection
(K) of the Warrants. If this Agreement and the related financing statements
shall have been terminated prior to the date on which Borrower is notified of
the exercise of Lenders' rights under subsection (K) of the Warrants, the
effectiveness of this Agreement shall automatically continue or be reinstated
with respect to all amounts payable in accordance with the terms of the Warrants
upon notice to Borrower of the exercise of Lenders' rights under subsection (K)
of the Warrants.

             9. Miscellaneous. Time is of the essence of this agreement.  Except
as otherwise defined in this agreement, all terms herein shall have the meanings
provided by the Uniform Commercial Code as it has been adopted in the State of
Michigan. Any delay on the part of the Lender in exercising any power,



                                       6




<PAGE>   66




privilege, or right hereunder, or under any other document executed by the
Borrower to the Lender in connection herewith, shall not operate as a waiver
thereof, and no single or partial exercise thereof or any other power,
privilege, or right shall preclude other or further exercise thereof. The waiver
by the Lender of any default of the Borrower shall not constitute a waiver of
subsequent default. All rights, remedies, and powers of the Lender hereunder are
irrevocable and cumulative, and not alternative or exclusive, and shall be in
addition to all rights, remedies, and powers given hereunder or in or by any
other instruments or by the provision of the Uniform Commercial Code as adopted
in the State of Michigan, or any other laws now existing or hereinafter enacted.

             This agreement has been delivered in the State of Michigan and
shall be construed in accordance with the laws of the State of Michigan.
Whenever possible, each provision of this agreement shall be interpreted in such
manner as to be effective and valid under applicable law; but, if any provision
of this agreement shall be prohibited by or invalid under applicable law, such
provision shall be ineffective to the extent of such provision or the invalidity
without invalidating the remainder of such provision or the remaining provisions
of this agreement. The rights and privileges of the Lender hereunder shall inure
to the benefits of its successors and assigns, and this agreement shall be
binding on all successors and assigns of the Borrower. The Borrower may not
assign this agreement or any benefits accruing to it hereunder without the
express written consent of the Lender.

             This agreement has been negotiated between Borrower and Lender and
shall be deemed to be mutually drafted by them.

             In witness whereof, the parties have executed this Agreement on the
date and year first above written.

LENDERS:                                     BORROWERS:

WHITE PINES LIMITED PARTNERSHIP I            GENOMIC SOLUTIONS, INC.
By: White Pines G.P., L.L.C.,
    its general partner


By:                                          By:
   ---------------------------------            -------------------------------
   Frederick L. Yocum, Chairman                 Jeffrey S. Williams
                                                President


PACIFIC CAPITAL, L.P.                        GENOMIC SOLUTIONS, LTD.
By: WP Pacific G.P., L.L.C.
    a general partner



By:                                          By:
   ---------------------------------            -------------------------------
   Frederick L. Yocum, Chairman






                                       7

<PAGE>   67




IAN R. N. BUND                               GENOMIC SOLUTIONS, K.K.

YOCUM CONSULTING ASSOCIATES, INC.
VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C
RONALD G. KALISH LIVING TRUST U/A/D          By:
   SEPTEMBER 9, 1997                            -------------------------------
McDONALD INVESTMENTS INC. CUSTODIAN
   FBO DANIEL J. BOYLE IRA ROLLOVER
   ACCOUNT #85314893
KANTNER AND ASSOCIATES PROFIT SHARING
   PLAN U/A/D JANUARY 1, 1991
MICHAEL G. WILLIAMS

By:  White Pines Management, L.L.C.,
     a Michigan limited liability
     company, attorney-in-fact

By:
   ---------------------------------
   Frederick L. Yocum, Chairman

CHASE VENTURE CAPITAL ASSOCIATES, L.P.

By:
   ---------------------------------
AMERICAN HEALTHCARE FUND II

By:
   ---------------------------------

------------------------------------
J. MATTHEW MACKOWSKI


------------------------------------
ROBERT G. SHEPLER


------------------------------------
JOHN J. MACKOWSKI


GROVE INVESTMENT PARTNERS


By:
   ---------------------------------

------------------------------------
LAWRENCE J. KENT


------------------------------------
JEFFREY S. WILLIAMS


------------------------------------
KEVIN A. AUTON


                                       8



<PAGE>   68



------------------------------------
ANDREW A. JAKIMCIUS


------------------------------------
MICHAEL P. KUREK


------------------------------------
STEVEN J. RICHVALSKY





                                       9


<PAGE>   69




                                   EXHIBIT D

                            SUBORDINATION AGREEMENT


<PAGE>   70






                             SUBORDINATION AGREEMENT
                          (All Indebtedness and Liens)

Genomic Solutions, Inc., Genomic Solutions, Ltd., and Genomic Solutions K.K.
(each, a "Borrower" and, together the "Borrowers") are indebted to the
undersigned (each a "Creditor" and collectively "Creditors") in the aggregate
principal sum of three Million five hundred thousand Dollars ($3,500,000)
evidenced by [ ] AN OPEN ACCOUNT [x] PROMISSORY NOTES [ ] OTHER (DESCRIBE) ____
___________ which indebtedness is [ ] UNSECURED [x] SECURED by substantially all
assets of the Borrowers, and Creditors are or may become financially interested
in Borrowers and desire to aid Borrowers in obtaining or having continued
financial accommodations, whether by way of loan, commitment to loan,
discounting of instruments, extensions of credit or the obtaining of any other
financial aid from Comerica Bank ("Bank").

In order to induce the Bank to extend or to continue to extend financial
accommodations to Borrowers from time to time, whether by way of a loan,
commitment to loan, discounting of instruments, extension of credit or otherwise
and in consideration of any of these financial accommodations, Bank, Borrowers
and Creditors agree as follows:

1.   Any and all obligations and liabilities of Borrowers to Creditors,
     including, without limit, principal and interest payments, whether direct
     or indirect, absolute or contingent, joint or several, secured or
     unsecured, due or to become due, now existing or later arising and whatever
     the amount and however evidenced (the "Subordinated Indebtedness"), are
     subordinated in right of payment to any and all obligations and liabilities
     of Borrowers to the Bank, including, without limit, principal and interest
     payments, whether direct or indirect, absolute or contingent, joint or
     several, secured or unsecured, due or to become due, now existing or later
     arising and however evidenced, together with all other sums due thereon and
     all costs of collecting the same (including, without limit, reasonable
     attorney fees) for which Borrowers are liable (the "Senior Indebtedness")
     provided, however, that Senior Indebtedness does not include aggregate
     principal amounts at any one time outstanding in excess of $3,000,000
     during 1999, in excess of $6,000,000 during 2000, in excess of $7,000,000
     during 2001 or in excess of $8,000,000 during 2002 or thereafter.

2.   Except as otherwise provided in this agreement, Creditors will not ask for,
     demand, sue for, take or receive (by way of voluntary payment,
     acceleration, set-off or counterclaim, foreclosure or other realization on
     security, dividends in bankruptcy or otherwise), or offer to make any
     discharge or release of, any of the Subordinated Indebtedness, and
     Creditors
<PAGE>   71
     waive any such rights with respect to the Subordinated Indebtedness nor
     shall Creditors exercise any rights of subrogation or other similar rights
     with respect to the Senior Indebtedness,

3.   Subject to the provisions of Subsection 20(B) below, Creditors will not
     exercise any of Creditors' rights in any collateral now or later securing
     the Subordinated Indebtedness. All rights of Creditors in any collateral
     now or later securing the Subordinated Indebtedness are subordinated to all
     rights of the Bank now or later existing in any of the same collateral
     securing the Senior Indebtedness.


4.   The Bank, in its own name or in the name of Creditors, may collect and
     enforce the Subordinated Indebtedness and all claims and demands of
     Creditors in connection therewith, by proof of debt in bankruptcy, or in
     any other proceeding involving dissolution, insolvency, liquidation or an
     adjustment of the indebtedness of Borrower. Creditors make, constitute and
     appoint Bank their true and lawful attorney-in-fact with full power of
     substitution to take any action in furtherance of the foregoing in the
     event Creditors fail to do so promptly following request by Bank,
     including, but not limited to, the signing of proofs of claim, evidence
     of indebtedness, and the execution and delivery of all documents and
     agreements necessary to obtain or accomplish any protection for or
     collection or disposition of any part of the Subordinated Indebtedness or
     any collateral. Such appointment shall be deemed irrevocable and coupled
     with an interest.

5.   Should any payment, distribution or security or proceeds from these be
     received by Creditors upon or with respect to the Subordinated Indebtedness
     contrary to the terms of this Agreement, Creditors shall immediately
     deliver same to the Bank in the form received (except for endorsement or
     assignment by Creditors where required by the Bank), for application on
     the Senior Indebtedness (whether or not then due and in such order of
     maturity as Bank elects) and, until so delivered, the same shall be held in
     trust by Creditors as the property of the Bank.

6.   Each Creditor represents and warrants severally but not jointly that it has
     not made or permitted to be made any assignment, transfer, pledge, or
     disposition for collateral purposes or otherwise, of all or any part of the
     Subordinated Indebtedness or any collateral or other security for the
     Subordinated Indebtedness. The Creditors agree that any instrument or
     document evidencing the Subordinated Indebtedness shall at all times bear
     the following legend:

     The rights of the holder of this Note to receive payment are subject and
     subordinate to the payment of all obligations of maker or obligor to
     Comerica Bank, and its successors and assigns, under the terms of the
     Subordination Agreement dated October  , 1999 executed by Genomic
     Solutions, Inc., the payee of this note, et al.

7.   This Agreement constitutes a continuing agreement of subordination, even
     though at times Borrowers are not indebted to the Bank. The Bank may
     continue, in reliance on this Agreement, without notice to Creditors, to
     lend monies, extend credit, modify, renew or



                                       2


<PAGE>   72

     make other financial accommodations, to or for the account of Borrowers
     until the fourteenth (14th) day ("effective date") following delivery by
     Creditors to Bank of revocation of this Agreement. Any such notice of
     revocation shall not be effective as to any Senior Indebtedness existing at
     the effective date of revocation or any Senior Indebtedness created after
     that pursuant to any commitment or agreement of the Bank or pursuant to
     any Borrower loan (whether advances or readvances by the Bank after the
     effective date of revocation are optional or obligatory) existing at the
     effective date of revocation or any modifications or renewals of any such
     Senior Indebtedness, whether in whole or in part. Possession by the Bank of
     any note or other evidence of indebtedness made, endorsed or guaranteed by
     Borrower shall be conclusive evidence (but not the only means of
     establishing) that Borrower is indebted to the Bank.

8.   (INTENTIONALLY OMITTED]

9.   Each Creditor delivers this Agreement based solely on its independent
     investigation of (or decision not to investigate) the financial condition
     of Borrowers and is not relying on any information furnished by the Bank.
     Each Creditor assumes full responsibility for obtaining any further
     information concerning Borrowers' financial condition, the status of the
     Senior Indebtedness or any other matter which it may deem necessary or
     appropriate now or later. Each Creditor waives any duty on the part of the
     Bank, and agrees that it is not relying upon nor expecting the Bank to
     disclose to it any fact now or later known by the Bank, whether relating to
     the operations or condition of Borrowers, the existence, liabilities or
     financial condition of any guarantor of the Senior Indebtedness, the
     occurrence of any default with respect to the Senior Indebtedness, or
     otherwise, notwithstanding any effect such fact may have upon Creditor's
     risk or Creditor's rights against any Borrower. Each Creditor knowingly
     accepts the full range of risk encompassed in this Agreement, which risk
     includes, without limit, the possibility that Borrowers may incur Senior
     Indebtedness to the Bank after the financial condition of Borrowers, or its
     ability to pay Borrowers' debts as they mature, has deteriorated. Each
     Creditor acknowledges and agrees that the Bank's rights under this
     Agreement are not conditioned upon pursuit by the Bank of any remedy the
     Bank may have against Borrowers or any other person or any other security.

10.  The Bank, in its sole discretion, without notice to Creditors, may release
     or exchange any security now or later held by the Bank for payment of the
     Senior Indebtedness or release any party now or later liable for payment of
     the Senior Indebtedness without affecting in any manner the Bank's rights
     under this Agreement. Each Creditor acknowledges and agrees that the Bank
     has no obligation to acquire or perfect any lien on or security interest in
     any asset(s), whether realty or personalty, to secure payment of the Senior
     Indebtedness, and that it is not relying upon assets in which the Bank has
     or may have a lien or security interest for payment of the Senior
     Indebtedness.

11.  Notwithstanding any prior revocation, termination surrender, or discharge
     of this Agreement in whole or in part, the effectiveness of this Agreement
     shall automatically continue or be reinstated in the event that any payment
     received or credit given by the Bank in respect of the Senior Indebtedness
     is returned, disgorged, or rescinded under any applicable state or




                                       3
<PAGE>   73
     federal law, including, without limitation, laws pertaining to bankruptcy
     or insolvency, in which case this Agreement, shall be enforceable against
     each Creditor as if the returned, disgorged, or rescinded payment or credit
     had not been received or given by the Bank, and whether or not the Bank
     relied upon this payment or credit or changed its position as a consequence
     of it. In the event of continuation or reinstatement of this Agreement,
     each Creditor agrees upon demand by the Bank to execute and deliver to the
     Bank those documents which the Bank determines are appropriate to further
     evidence (in the public records or otherwise) this continuation or
     reinstatement, although the failure of the Creditor to do so shall not
     affect in any way the reinstatement or continuation.

12.  Each Creditor waives any right to require the Bank to: (a) proceed against
     any person or property; or (b) pursue any other remedy in the Bank's power.
     Each Creditor waives notice of acceptance of this Agreement and
     presentment, demand, protest, notice of protest, dishonor, notice of
     dishonor, notice of default, notice of intent to accelerate or demand
     payment of any Senior Indebtedness, and diligence in collecting any Senior
     Indebtedness, and agrees that the Bank may, once or any number of times,
     modify the terms of any Senior Indebtedness, compromise extend, increase,
     accelerate, renew or forbear to enforce payment of any or all Senior
     Indebtedness, or permit any Borrower to incur additional Senior
     Indebtedness, all without notice to Creditors and without affecting in any
     manner the unconditional obligations of Creditors under this Agreement.

13.  Each Creditor acknowledges that the Bank has the right to sell, assign,
     transfer, negotiate or grant participations or any interest in, any or all
     of the Senior Indebtedness and any related obligations, including without
     limit this Agreement. In connection with the above, but without limiting
     its ability to make other disclosures to the full extent allowable, the
     Bank, may disclose all documents and information which the Bank now or
     later has or acquires relating to Creditor and this Agreement, however
     obtained. Creditor further agrees that the Bank may disclose such documents
     and information to Borrowers. Each Creditor further agrees that the Bank
     may provide information relating to this Agreement or relating to Creditors
     to the Bank's parent, affiliates, subsidiaries and service providers.

14.  No waiver or modification of any rights under this Agreement shall be
     effective unless the waiver or modification shall be in writing and signed
     by an authorized officer of the applicable party. Each waiver or
     modification shall be a waiver or modification only with respect to the
     specific matter to which the waiver or modification relates and shall in no
     way impair the rights of the party or the Obligations of the other parties
     in any other respect.

15.  This Agreement shall bind and be for the benefit of Creditors and the Bank
     and their respective successors and assigns, and shall be construed
     according to the laws of the State of Michigan, without regard to conflict
     of laws principles. If this Agreement is executed by two or more persons,
     it shall bind each of them individually as well as jointly.

16.  The term "Borrower", as used in this Agreement, includes any person,
     corporation, partnership or other entity which succeeds to the interests or
     business of a Borrower named above, and the terms "Senior Indebtedness" and
     "Subordinated Indebtedness" include


                                       4
<PAGE>   74


     indebtedness of any successor Borrower to the Bank and Creditors.
     Reference to the Borrower' indebtedness in this Agreement refers to
     indebtedness of any one or more Borrowers.

17.  Creditors jointly and not severally agree to reimburse the Bank upon
     demand for any and all costs and expenses (including, without limit, court
     costs, legal fees, and reasonable attorney fees whether inside or outside
     counsel is used, whether or not suit is instituted and, if instituted,
     whether at the trial or appellate level, in a bankruptcy, probate or
     administrative proceeding, or otherwise) incurred in enforcing the duties
     and obligations of Creditors under Section 4 of this Agreement.

18.  Each Creditor waives any defense against the enforceability of this
     Agreement based upon or arising by reason of the application by any
     Borrower of the proceeds of any Indebtedness for purposes other than the
     purposes represented by any Borrower to the Bank or intended or understood
     by the Bank or Creditors. Each Creditor waives all rights to require the
     Bank to marshall the Collateral or any other property the Bank may at any
     time have as security for the Indebtedness and waives all right to require
     the Bank to first proceed against any guarantor or other person before
     proceeding against the Collateral.

19.  The relative priorities of the Bank and Creditors in the Collateral as set
     forth in this Agreement control irrespective of the time, method or order
     of attachment or perfection of the liens and security interests acquired by
     the parties in the Collateral and irrespective of the priorities as would
     otherwise be determined by reference to the Uniform Commercial Code or
     other applicable laws. Creditors shall not contest die validity, priority
     or perfection of the Bank's security interest in the Collateral (regardless
     of whether the Bank's security interest in the Collateral is valid or
     perfected). The priorities of any liens or security interests of the
     parties in any property of the Borrowers other than the Collateral are not
     affected by this Agreement and shall be determined by reference to
     applicable law. The Bank's rights under this Agreement are in addition to,
     and not in substitution of, its rights under any other subordination
     agreement with any Creditor.

20.  Special Provisions:

     A.   Notwithstanding anything to the contrary in this Agreement, Creditors
          may ask for, demand, sue for, take or receive from Borrowers the
          regularly scheduled quarterly payments which may come due under the
          above-described promissory notes ("Notes") and expense reimbursements
          permitted thereunder; provided, however, that Creditors may not ask
          for, demand, sue for, take or receive from Borrower any such payments
          after Creditors are given written notice by the Bank that a default or
          an event of default exists or has occurred under any note(s),
          guaranty(ies), and/or agreement(s) between the Bank and Borrower or
          that any loan(s) between Borrower and the Bank has (have) been called
          (a "Standstill Notice"). All such payments due Creditors under the
          Notes must be suspended until such time (if ever) as Creditor receives
          subsequent written notice from the Bank stating that the default has
          been cured and/or the loan(s) has (have) been paid. The Bank agrees to
          give Borrower




                                       5
<PAGE>   75




          copies of the notices, but the Bank's failure to do so shall not
          affect its rights under this Agreement or any other agreement with
          Borrower. The Notes may not be modified or prepaid without the prior
          written consent of the Bank.

     B.   Notwithstanding any of the other provisions of this Agreement, if
          within 120 days after receipt by Creditors of a Standstill Notice the
          Bank has not accelerated the Senior Indebtedness and initiated legal
          action against Borrowers or the Collateral, and continued to
          diligently pursue such legal action and/or remedies, Creditors may
          accelerate the due date of the Notes, may demand and sue for the
          amounts due under the Notes and exercise any of Creditors' rights in
          any Collateral now or later securing the Subordinated Indebtedness
          regardless of the issuance of a subsequent Standstill Notice.
          Creditors shall give the Bank written notice of their intent to so
          exercise their remedies ten days prior to exercising such remedies. In
          exercising remedies against the collateral, the Creditors shall
          cooperate with the Bank and shall remit any proceeds of the sale or
          disposition of collateral to the Bank to be applied to the Senior
          Indebtedness until such time as the Senior Indebtedness is paid in
          full. In no event shall a Standstill Notice arising from default other
          than a payment default be in effect without the commencement of legal
          action by the Bank as provided in this paragraph for more than 120
          days in any 12 month period.

     C.   In the event of any distribution, division or application, whether
          partial or complete, voluntary or involuntary, by operation of law or
          otherwise, of all or any part of Borrowers' assets, or the proceeds of
          Borrowers' assets, in whatever form, to Creditors of Borrower or upon
          any indebtedness of Borrowers, whether by reason of the liquidation,
          dissolution or other winding-up of Borrowers, or by reason of any
          execution sale, receivership, insolvency, or bankruptcy proceeding,
          assignment for the benefit of Creditors, proceedings for
          reorganization, or readjustment of Borrowers or Borrowers' properties,
          then and in such event, (a) the Senior Indebtedness shall be paid in
          full before any payment is made upon the Subordinated Indebtedness,
          and (b) all payments and distributions, of any kind or character and
          whether in case, property, or securities, which shall be payable or
          deliverable upon or respect of the Subordinated Indebtedness shall
          be paid or delivered directly to Bank for application in payment of
          the amounts then due on the Senior Indebtedness until the Senior
          Indebtedness shall have been paid in full.

     D.   Upon payment in full of the Senior Indebtedness, Creditor shall be
          subrogated to any rights, liens and security interests of Bank
          pursuant to the Senior Indebtedness.

     E.   This agreement may be executed in any number of counterparts, each of
          which shall constitute an original and all of which taken together
          shall constitute one and the same agreement.

     F.   The parties acknowledge and agree that Bank is holding original stock
          certificates of Genomic Solutions, Ltd. and Genomic Solution, K.K. as
          security for the Senior Indebtedness and that Bank will not release
          those stock certificates without first


                                       6
<PAGE>   76


          giving Creditors the opportunity to take possession of those
          certificates to perfect their security interest in those stock
          certificates as security for the Subordinated Indebtedness.

6.   This Agreement is in addition to and not substitution for the Subordination
     Agreement dated as of April 23, 1999 among certain of the Creditors and the
     Bank.

THE UNDERSIGNED AND THE BANK ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A
CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED. EACH PARTY, AFTER CONSULTING (OR
HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF THEIR CHOICE, KNOWINGLY
AND VOLUNTARILY, AND FOR THEIR MUTUAL BENEFIT, WAIVES ANY RIGHT TO TRIAL BY JURY
IN THE EVENT OF LITIGATION REGARDING THE PERFORMANCE OR ENFORCEMENT OF, OR IN
ANY WAY RELATED TO, THIS AGREEMENT.




                                       7
<PAGE>   77


IN WITNESS WHEREOF, Creditors and Bank have caused this Agreement to be executed
as of October    , 1999.

CREDITORS:

WHITE PINES LIMITED PARTNERSHIP I

By:  White Pines G.P., L.L.C.,
     its general partner

By:
   ------------------------------------
      Frederick L. Yocum, Chairman

PACIFIC CAPITAL, L.P.
By:  WP Pacific  G.P.,  L.L.C.
     a general partner

BY:
   ------------------------------------
      Frederick L. Yocum, Chairman

IAN R. N. BUND
YOCUM CONSULTING ASSOCIATES, INC.
VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C.
RONALD G. KALISH LIVING TRUST U/A/D
          SEPTEMBER 9, 1997

MCDONALD INVESTMENTS INC. CUSTODIAN
FBO DANIEL J. BOYLE IRA  ROLLOVER
ACCOUNT #85314893




                                       8
<PAGE>   78




KANTNER AND ASSOCIATES PROFIT SHARING
         PLAN U/A/D JANUARY 1, 1991
MICHAEL G. WILLIAMS

By:    White Pines Management, L.L.C.
       a Michigan limited liability company,
       attorney-in fact

By:
   ------------------------------------
       Frederick L. Yocum, Chairman

CHASE VENTURE CAPITAL ASSOCIATES, L.P.

By:
   ------------------------------------


AMERICAN HEALTHCARE FUND II


By:
   ------------------------------------



---------------------------------------
J. MATTHEW MACKOWSKI


---------------------------------------
ROBERT G. SHEPLER

---------------------------------------
JOHN J. MACKOWSKI


GROVE INVESTMENT PARTNERS

By:
   ------------------------------------


---------------------------------------
LARRY KENT





                                       9
<PAGE>   79



---------------------------------------
JEFFREY S. WILLIAMS

---------------------------------------
KEVIN A. AUTON

---------------------------------------
ANDREW A. JAKIMCIUS

---------------------------------------
MICHAEL P. KUREK

---------------------------------------
STEVEN J. RICHVALSKI





                                       10
<PAGE>   80


COMERICA BANK                       BANK'S ADDRESS:

By:                                 500 Woodward Avenue
   --------------------------       Detroit, MI 48226

Its:
    -------------------------


                            BORROWER'S ACKNOWLEDGMENT

The undersigned ("Borrowers") accept notice of the subordination created by this
Agreement and agree that they will take no action inconsistent with this
Agreement. Borrowers agree that the Bank may, at its option, without notice and
without limiting Bank's other rights, upon any breach by Creditors holding at
least 10% of the aggregate outstanding principal amount of the Subordinated
Indebtedness ("Material Creditors") of, or purported termination by Material
Creditors of, this Agreement, declare all Senior Indebtedness to be immediately
due and payable and/or terminate any commitments of Bank to Borrowers.

GENOMIC SOLUTIONS, INC.                              BORROWERS' ADDRESS

By:
   -----------------------------                     4355 Varsity Drive
          Jeffrey S. Williams                        Ann Arbor, MI 48108
Its:      President





GENOMIC SOLUTIONS, LTD



By:
   -----------------------------
Its:
    ----------------------------



GENOMIC SOLUTIONS, K.K.



By:
   -----------------------------
Its:
    ----------------------------





                                       11
<PAGE>   81
                                   EXHIBIT E

                               BORROWER'S OPINION


<PAGE>   82


                                    EXHIBIT F

                AMENDMENT NO. 1 TO REGISTRATION RIGHTS AGREEMENT

                              FILED AS EXHIBIT 4.7




<PAGE>   83




                                   EXHIBIT G

                             SHAREHOLDER AGREEMENT


<PAGE>   84


                                   EXHIBIT H

                        ASSIGNMENT AND PLEDGE AGREEMENT


<PAGE>   85


                         ASSIGNMENT AND PLEDGE AGREEMENT

     1.   Genomic Solutions, Inc., a Delaware corporation, 4355 Varsity Drive,
Suite E, Ann Arbor, Michigan 48108 (herein "Pledgor"), in consideration of
financial accommodations given, or to be given, or continued to Pledgor, Genomic
Solutions, Ltd., a United Kingdom corporation, Unit 3, Forge Close, Little End
Road, Eaton Socon, St. Neots, Cambridgshire, England PE193TP and/or Genomic
Solutions, K.K., a Japanese corporation, Gotanda Chuo Bldg. 2F, 3-5,
Higashigotanda 2-chome, Shinagawa-ku, Tokyo 141-0022, Japan (Genomic Solutions,
Ltd. and Genomic Solutions, K.K. each sometimes hereinafter being referred to as
a "Subsidiary" and sometimes hereinafter collectively referred to as the
"Subsidiaries" and each of Pledgor, Genomic Solutions, Ltd. and Genomic
Solutions, K.K. sometimes hereinafter referred to as "Borrower", a "Borrower" or
the "Borrower" and collectively sometimes referred to as the "Borrowers") by
White Pines Limited Partnership I, a Michigan limited partnership, 2401 Plymouth
Road, Suite B, Ann Arbor, Michigan 48105 (hereinafter referred to as "WPLP"),
Pacific Capital, L.P., a Delaware limited partnership, 2401 Plymouth Road,
Suite B, Ann Arbor, Michigan 48105 (hereinafter referred to as "Pacific"), Chase
Venture Capital Associates, L.P., a California limited partnership, 380 Madison
Avenue, 12th Floor, New York, New York 10017 (hereinafter referred to as
"Chase"), American Healthcare Fund II, a Delaware limited partnership, 4430
Arapahoe Avenue, Suite 220, Boulder, Colorado 80303 (hereinafter referred to as
"American"), Ian R. N. Bund, 2401 Plymouth Road, Suite B, Ann Arbor, Michigan
48105 (hereinafter referred to as "Bund"), Yocum Consulting Associates, Inc., an
Ohio corporation, 4622 Wyndwood Drive, Toledo, Ohio 43623 (hereinafter referred
to as "Yocum"), Volunteer Healthcare Associates, L.L.C., a Tennessee limited
liability company, 6 Cadillac Drive, Suite 310, Brentwood, Tennessee 37027
(hereinafter referred to as "Volunteer"), J. Matthew Mackowski, 275 Post Street,
Suite 600, San Francisco, California 94108 (hereinafter referred to as
"Mackowski-CA"), Robert G. Shepler, 275 Post Street, Suite 600, San Francisco,
California 94108 (hereinafter referred to as "Shepler"), John J. Mackowski,
1506 Birkdale Lane, Ponte Verde Beach, Florida 32082 (hereinafter referred to as
"Mackowski-FL"), Grove Investment Partners, an Illinois partnership, 336 Essex
Road, Kenilworth, Illinois 60043 (hereinafter referred to as "Grove") Ronald G.
Kalish Living Trust u/a/d September 9, 1997, 445 Grand Bay Drive, #1009, Key
Biscayne, Florida 33149 (hereinafter referred to as "Kalish"), McDonald
Investments Inc. Custodian FBO Daniel J. Boyle IRA Rollover Account #85314893,
2550 Som Center Road, Suite 300, Willoughby Hills, Ohio 44094 (hereinafter
referred to as "Boyle"), Kantner and Associates Profit Sharing Plan u/a/d
January 1, 1991, 661 Airport Blvd., Suite 2A, Ann Arbor, Michigan 48108
(hereinafter referred to as "Kantner"), Michael G. Williams, 18000 Cavanaugh
Lake Road, Chelsea, Michigan 48118 (hereinafter referred to as "Williams"),
Lawrence J. Kent, 404 E. Lancaster Ave., Wayne, Pennsylvania 19087 (hereinafter
referred to as "Kent"), Jeffrey S. Williams, 7049 Suncrest Drive, Saline,

                                       1
<PAGE>   86
Michigan 48176 (hereinafter referred to as "JWilliams"), Kevin A. Auton, 42
Croftfield Road, Godmanchester, Huntingdon, Cambridgeshire PE18 8ED (hereinafter
referred to as "Auton"), Andrew A. Jakimcius, 1096 Heritage Drive, Saline,
Michigan 48176 (hereinafter "Jakimcius"), Michael P. Kurek, 2720 Holyoke Lane,
Ann Arbor, Michigan 48103 (hereinafter referred to as "Kurek") and Steven J.
Richvalsky, 12215 Deer Creek Circle, Plymouth, Michigan 48170 (hereinafter
referred to as "Richvalsky") (WPLP, Pacific, Chase, American, Bund, Yocum,
Volunteer, Mackowski-CA, Shepler, Mackowski-FL, Grove, Kalish, Boyle, Kantner,
Williams, Kent, JWilliams, Auton, Jakimcius, Kurek and Richvalsky each being
sometimes hereinafter referred to as "Lender", a "Lender" or the "Lender" and
collectively as "Lenders"), and as collateral security for the payment of all
debts, obligations or liabilities now or hereafter existing, absolute or
contingent, including any extensions or renewals thereof, present or future,
direct or indirect, due or to become due from the Borrowers to the Lenders under
(i) the Promissory Notes in the amount of three million five hundred thousand
and no/100 ($3,500,000) dollars, (ii) the Business Loan Agreement of even date
herewith between Borrowers and Lenders, and (iii) all obligations due under any
of the Loan Documents (as defined in the Business Loan Agreement), (all of which
shall be called "Indebtedness"), hereby irrevocably assigns, orders, transfers,
pledges and sets over to Lenders, their successors and assigns:

          (a)  All distributions, profit distributions, proceeds from sale of
stock included in the Collateral, and any and all other distributions due to
Pledgor from each Subsidiary and any successor in interest thereto.

          (b)  All shares and other property delivered to and deposited with the
Lenders, all property which is hereafter delivered to or comes into the
possession or control of the Lenders in any manner and for any purpose during
the existence of this Agreement, together with the stock rights, rights to
subscribe, liquidating dividends, stock dividends, dividends paid in stock, new
securities or other property which the Pledgor is entitled to receive and grants
to Lenders a continuing security interest in certain instruments, stock, chattel
paper, notes, debentures or other securities, to wit:

All shares of and 100% of its ownership interest in each Subsidiary as well
as any and all other property now or hereafter in the Lenders' possession or
control (all of the above set forth in subparagraph 1(a) and 1(b) herein
collectively termed "Collateral").

     2.   Pledgor warrants:

          (a)  that it is the lawful owner of all the Collateral including one
hundred percent (100%) of the capital stocks of each Subsidiary free of all
claims, liens, or encumbrances

                                       2
<PAGE>   87
whatsoever other than as set forth in the Business Loan Agreement and the
security interest granted to Lenders pursuant hereto;

          (b)  all written information furnished by Pledgor to Lenders
hereafter, will be correct and true as of the date given; and

          (c)  that the pledge and security interest in the Collateral arising
out of this Agreement has been given and granted to induce the Lenders to
extend, or to continue to extend, credit accommodations to the Borrowers.

     3.   At any time, after an event of default under the Business Loan
Agreement or the Promissory Notes, Warrants or Security Agreement contemplated
therein shall occur and is not cured within any applicable grace period and
without notice, and at the expense of the Pledgor, Lenders may but are not
obligated to:

          (a) collect all dividends, interest, principal payments and other sums
payable upon or on account of the Collateral;

          (b) Enter into an extension, reorganization, deposit, merger or
consolidation agreement, or other agreement related to or affecting the
Collateral, and in this connection may deposit or surrender control of the
Collateral, accept other property in exchange for the Collateral, and perform
such acts and things as it considers proper. Money or property received in
exchange for the Collateral shall be applied to the Indebtedness secured hereby;

          (c) compromise or settle claims or disputes as it deems desirable or
proper with reference to the Collateral;

          (d)  Insure, process and preserve the Collateral;

          (e)  Transfer the title to the Collateral to its name or the name of
the nominee;

          (f)  Exercise as to the Collateral, all the rights, powers and
remedies of an owner; and

          (g) Perform any and all acts which Lenders in good faith deem
necessary for the protection and preservation of Collateral or its value or
Lenders' security interest therein, including, but not limited to, transferring
any Collateral to Lenders' own name and receiving the income thereon as
additional security hereunder.

     4.   If, during the term of this Agreement, any stock dividends,
reclassifications, adjustments or other changes are made in the capital
structure of the corporation or other entity issuing the Collateral or any
portion thereof, whether it is a

                                       3
<PAGE>   88

reorganization, recapitalization, share split-up, a combination of shares,
merger, transfer, or consolidation, all new, additional or substituted shares
for securities of whatever class, issued with respect to the Collateral by
reason of change, shall be delivered to the Lenders immediately after issuance.
The Lenders shall hold the shares or security so issued as the Collateral under
the terms of this Agreement. If, during the term of this Agreement, warrants,
options, or other rights with respect to the Collateral are issued to the
Pledgor, and if the Pledgor exercises any such warrants, option, or right, all
new stock or securities received upon such exercise shall be delivered by the
Pledgor to the Lenders immediately after they are issued. Such new stock or
securities shall be held by the Lenders as Collateral under the terms of the
Agreement.

     5.   (a) At any time after a default shall occur in any of the Indebtedness
according to the terms thereof, which default is not cured within any applicable
grace period, including the Notes, Security Agreements, Business Loan Agreement,
Warrants, or any other Loan Document between Lenders and Borrowers and/or the
Pledgor (the terms of such being incorporated by reference herein); including a
material impairment in any way of the value of the Collateral or Lender's rights
therein, the Lender may at its option, without notice or demand to Pledgor,
declare all or part of the Indebtedness to be immediately due and payable. The
Lender shall have the remedies of a secured party under the Uniform Commercial
Code of the State of Michigan. The Lenders may sell the Collateral in such
manner and for such price as the Lenders deem appropriate without any liability
for any loss due to decrease in the market value of the Collateral during the
period held. The Lender shall have the right to purchase all or part of the
Collateral at public or private sale. If notification of intended disposition of
any of the Collateral is required by law, such notification shall he deemed
reasonable and properly given if mailed, postage prepaid, at least seven (7)
days before any such disposition to any address of the Pledgor appearing on the
records of the Lenders. Lenders shall have the right, but shall not be
obligated, to vote the Collateral.

          (b) Upon the exercise of Lenders' rights to receive distributions with
respect to the Collateral as provided in Section 3 above, Lenders shall be
vested with all the rights of the Pledgor in respect thereto, the ability to
notify any obligor or payor of the assignment and the ability to execute any
instrument on behalf of the Pledgor in settlement or fulfillment thereof. In
such event, Pledgor agrees to execute such additional assignments, instruments
and documents as the Lenders may request to evidence the assignment. The Pledgor
agrees that if thereafter it receives any payment of any such sums it shall
receive same as the agent of the Lenders and the Pledgor agrees to transmit such
payment in the form in which it was received to the Lenders on the date of
receipt thereof, appropriately endorsed, if necessary, to permit negotiation by
the Lenders. In any event, the Lenders are authorized to endorse or to sign, in

                                       4
<PAGE>   89

the name of the Pledgor, any instrument of whatsoever nature to effect the
collection of said payments for application to all sums due the Lenders.

     6.   The Collateral shall be evidenced by share certificates registered in
the name of Pledgor and accompanied by stock powers duly executed in blank. Said
share certificates and duly executed stock powers have been delivered to Lenders
concurrently with the execution of this Agreement

     7.   The proceeds of any sale shall be applied in the following order:

          (a)  to pay all costs and expenses of every kind for care,
safekeeping, collection, sale, foreclosure, delivery or otherwise respecting the
Collateral (including reasonable expenses incurred in the protection of the
Lenders' title or lien upon or right in any of the Collateral, reasonable actual
expenses for legal services of any kind in connection therewith or making of
such sale or sales, insurance, commission for sale, or guaranty).

          (b)  to interest on all Indebtedness of the Borrowers to the Lenders;

          (c)  to principal thereof, whether or not such Indebtedness is due or
accrued. After such application, Lenders will account to Pledgor for any surplus
and Borrowers shall remain liable to Lenders for any deficiency.

     Application of proceeds as between particular debts, obligations, or
liabilities of Borrowers, shall be in the absolute and sole discretion of the
Lenders. The Lenders shall have the right in their sole discretion to determine
which rights, security liens, security interests, or remedies, they shall at any
time pursue, relinquish, subordinate, modify, or take any action with respect
thereto, without in any way modifying or affecting any other security for the
Indebtedness or any of the Lenders' rights hereunder.

     8.   Pledgor agrees that Lenders' security interest in the Collateral and
in any and all other property belonging to Pledgor, pledged or hypothecated, to
secure indebtedness shall be as valid as if Pledgor had duly assigned, released,
transferred and delivered said property to the Borrowers and the Borrowers, with
full ownership thereof, had pledged said property to secure all such
Indebtedness upon the terms herein stated.

     9.   Any transferee of, or endorser, guarantor, or surety paying the
indebtedness secured hereby may take over all or any part of the Collateral
subject hereto, and shall succeed to all rights of the Lenders in respect
thereto and the Lenders shall be under no further responsibility therefore.

                                       5
<PAGE>   90

     10.  The Pledgor authorizes Lenders, without notice or demand and without
affecting any liability on the Indebtedness to:

          (a) renew, extend, accelerate, or change the time for repayment or
other terms of the Indebtedness secured hereby, including increasing or
decreasing the rate of interest;

          (b) take and hold security other than the Collateral herein described,
for the payment of the Indebtedness and to exchange, substitute, transfer,
enforce, waive and release such security; and

          (c) release or substitute any Borrower, endorser, guarantor, or other
Pledgor of the Indebtedness.

     11.  The Pledgor waives presentment, demand for performance, notice of
non-performance, protest, notice of protest, or notice of dishonor in connection
with an obligation or evidence of indebtedness held by Lenders as Collateral, or
in connection with any obligation of or evidence of indebtedness which
represents the Indebtedness secured thereby. The Lenders shall not be required
to examine into the validity of or to exchange or to collect on any Collateral
subject to this Agreement or to take any action necessary to hold any
corporation, issuer, or other parties liable on the Collateral; and diligence in
looking after, preserving, or acting with respect to the Collateral or
collecting the same is hereby waived by the parties hereto.

     12.  No delay on the part of the Lenders in the exercise of any right or
remedy shall operate as a waiver thereof, and no single or partial exercise by
the Lenders of any right or remedy shall preclude other or further exercise
thereof or the exercise of any other right or remedy. All of the Lenders' rights
and remedies whether evidenced hereby or by any other writing, shall be
cumulative and may be exercised from time to time singularly or concurrently.

     13.  This is a continuing Agreement and the rights, powers and remedies
apply to all past, present and future Indebtedness of the Borrowers to the
Lenders including that arising under successive transactions which continue the
Indebtedness, increase or decrease it, or create new Indebtedness. No notice of
creation or existence of any Indebtedness or of any renewal, extension, or
modification thereof, need be given to Pledgor. This agreement and related
financing statements shall be terminated upon payment in full of the
Indebtedness and all other sums and expenses required to be paid thereby,
provided however that for purposes of the foregoing, no Indebtedness shall be
deemed to exist under the terms of the Warrants prior to such time as Borrower
has been notified of the exercise of Lenders' rights under subsection (K) of the
Warrants. If this Agreement and the related financing statements shall have been
terminated

                                       6
<PAGE>   91

prior to the date on which Borrower is notified of the exercise of Lenders'
rights under subsection (K) of the Warrants, the effectiveness of this Agreement
shall automatically continue or be reinstated with respect to all amounts
payable in accordance with the terms of the Warrants upon notice to Borrower of
the exercise of Lenders' rights under subsection (K) of the Warrants. The breach
of the terms of any Note, Warrant, Security Agreement, Pledge or Business Loan
Agreement of whatsoever nature between Borrowers and Lenders, which is not cured
within any applicable grace period, shall constitute a default and breach of
all such agreements including this agreement.

     14.  Lenders may deliver the Collateral or any part of it to the Pledgor
and the receipt by the Pledgor discharges the Lenders from any liability or
responsibility for said Collateral.

     15.  This Agreement shall be governed and interpreted according to the laws
of the State of Michigan without regard to its conflict of law principles.
Parties agree that all actions and proceedings arising in connection with this
Agreement shall be litigated in the State Courts or the Federal District Courts
in the State of Michigan. The parties hereby waive any right that they may have
to change the venue of any action against it by any other party in accordance
with this paragraph. The parties hereby consent and submit to the jurisdiction
and venue of the State Courts and Federal District Courts of the State of
Michigan. This Agreement shall inure to the benefit of and be binding upon the
Lenders, their successors and assigns, including the assignees of any
Indebtedness secured by this Agreement, and the Pledgor and its legal
representatives, successors and assigns. In the event any provision of this
Agreement shall be invalid or unenforceable, in full or in part, neither the
validity nor the enforceability of the remainder of this Agreement shall be
affected in any way.

     16.  Nothing herein contained shall be construed to bind Lenders to perform
any of the Pledgor's obligations under any of the Collateral as a shareholder.

     17  This Assignment and Pledge Agreement has been negotiated between the
parties and shall be deemed to have been mutually drafted by them.


     In Witness Whereof, the parties hereto have executed this Agreement this
28th day of October, 1999.


LENDERS:                                             BORROWERS:

WHITE PINES LIMITED PARTNERSHIP I                    GENOMIC SOLUTIONS, INC.
By: White Pines G.P., L.L.C.,
     its general partner

By:                                                  By:
   ---------------------------------                    ------------------------
    Frederick L. Yocum, Chairman                        Jeffrey S. Williams
                                                            President

                                       7
<PAGE>   92
PACIFIC CAPITAL, L.P.
By: WP PACIFIC G.P., L.L.C.                            GENOMIC SOLUTIONS, LTD.
    a general partner

By:                                                  By:
   ---------------------------------------              ------------------------
   Frederick L. Yocum, Chairman

IAN R. N. BUND                                       GENOMIC SOLUTIONS, K.K.
YOCUM CONSULTING ASSOCIATES, INC.
VOLUNTEER HEALTHCARE ASSOCIATES, L.L.C
RONALD G. KALISH LIVING TRUST U/A/D                  By:
     SEPTEMBER 9, 1997                                  ------------------------
McDONALD INVESTMENTS INC. CUSTODIAN
     FBO DANIEL J. BOYLE IRA ROLLOVER
     ACCOUNT #85314893
KANTNER AND ASSOCIATES PROFIT SHARING
     PLAN U/A/D JANUARY 1, 1991
MICHAEL G. WILLIAMS
By:       White Pines Management, L.L.C.,
          a Michigan limited liability
          company, attorney-in-fact

By:
   ---------------------------------------
   Frederick L. Yocum, Chairman

CHASE VENTURE CAPITAL ASSOCIATES, L.P.

By:
   ---------------------------------------

AMERICAN HEALTHCARE FUND II

By:
  ----------------------------------------


------------------------------------------
J. MATTHEW MACKOWSKI


------------------------------------------
ROBERT G. SHEPLER


------------------------------------------
JOHN J. MACKOWSKI

GROVE INVESTMENT PARTNERS

By:
   ---------------------------------------


------------------------------------------
LAWRENCE J. KENT

                                       8
<PAGE>   93

------------------------------------------
JEFFREY S. WILLIAMS


------------------------------------------
KEVIN A. AUTON


------------------------------------------
ANDREW A. JAKIMCIUS


------------------------------------------
MICHAEL P. KUREK


------------------------------------------
STEVEN J. RICHVALSKY

                                       9
<PAGE>   94
                             SECRETARY'S CERTIFICATE
                              GENOMIC SOLUTIONS INC.

     The undersigned Secretary of Genomic Solutions Inc., a Delaware corporation
(the "Corporation"), hereby certifies as follows:

     1.   The following persons are the duly elected and acting officers of the
          Corporation, holding the office(s) set forth opposite his name below:

<TABLE>
<CAPTION>
          Name                                   Office
<S>                                              <C>
          Jeffrey S. Williams                    President, Chief Executive Officer
          Steven J. Richvalsky                   Executive Vice President, Treasurer,
                                                 Secretary and Chief Financial Officer
          Andrew A. Jakimcius                    Executive Vice President of Operations
          Michael P. Kurek                       Executive Vice President, Marketing and Sales
          William M. Skea                        Vice President
          Frank C. Becker                        Vice President
          Gregory H. Kinch                       Vice President
          Mary F. Lopez                          Vice President
          Mary Stanaway                          Vice President
</TABLE>

     2.   The following persons are the duly elected and acting directors of the
          Corporation:

<TABLE>
<S>                                     <C>                            <C>
          Jeffrey S. Williams           Robert G. Shepler              P. Nicholas "Nick" King
          Dan Mitchell                  Damion E. Wicker               J. Matthew Mackowski
</TABLE>

     3.   Attached hereto as Exhibit A is a true and complete copy of the
          Amended and Restated Certificate of Incorporation of the Corporation,
          as amended, as certified by the Delaware Secretary of State as of
          October 15, 1999. No action has been taken to amend the Certificate of
          Incorporation since that date.

     4.   Attached hereto as Exhibit B is a true and complete copy of the
          Certificate of Good Standing of the Corporation, as certified by the
          Delaware Secretary of State on October 15, 1999.

     5.   Attached hereto as Exhibit C is a true and complete copy of the
          Certificate of Good Standing of the Corporation, as certified by the
          Michigan Secretary of State on October 28, 1999.

     6.   Attached hereto as Exhibit D is a true and complete copy of the Bylaws
          of the Corporation, in effect on the date hereof.

     7.   Attached hereto as Exhibit E is a true and complete copy of the
          Consent Resolution that was duly adopted by the Board of Directors of
          the Corporation as of October 11, 1999, which has not been altered,
          amended or repealed and is in full force and effect as of the date
          hereof.

     IN WITNESS WHEREOF, the undersigned has executed this Certificate this 28th
day of October, 1999.

                                     /s/ Steven J. Richvalsky
                                     -----------------------------------
                                     Steven J. Richvalsky, Secretary and Chief
                                     Financial Officer


Attested By:
/s/ Jeffrey S. Williams
-----------------------------------
Jeffrey S. Williams, President, and
Chief Executive Officer
<PAGE>   95


                                   EXHIBIT A


<PAGE>   96
                                                                          PAGE 1

                                State of Delaware

                        Office of the Secretary of State

                          -----------------------------

       I, EDWARD J. FREEL, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO
HEREBY CERTIFY THE ATTACHED ARE TRUE AND CORRECT COPIES OF ALL DOCUMENTS ON
FILE OF "GENOMIC SOLUTIONS INC." AS RECEIVED AND FILED IN THIS OFFICE.

       THE FOLLOWING DOCUMENTS HAVE BEEN CERTIFIED:

       CERTIFICATE OF INCORPORATION, FILED THE FIFTH DAY OF
DECEMBER, A.D. 1997, AT 9 O'CLOCK A.M.

       RESTATED CERTIFICATE, FILED THE TWENTY-FOURTH DAY OF
DECEMBER, A.D. 1997, AT 4:29 O'CLOCK P.M.

       CERTIFICATE OF AGREEMENT OF MERGER, FILED THE TWENTY-FOURTH DAY OF
DECEMBER, A.D. 1997, AT 4:30 O'CLOCK P.M.

       CERTIFICATE OF DESIGNATION, FILED THE THIRTEENTH DAY OF
MAY, A.D. 1998, AT 4 O'CLOCK P.M.

       CERTIFICATE OF AMENDMENT, FILED TEE TWENTY-SECOND DAY OF
MAY, A.D. 1998, AT 9:18 O'CLOCK A.M.

       CERTIFICATE OF DESIGNATION, FILED THE TWENTY-SECOND DAY OF
MAY, A.D. 1998, AT 9:19 O'CLOCK A.M.


                                     /s/ Edward J. Freel
[SECRETARY'S OFFICE SEAL]            -------------------------------------------
                                     Edward J. Freel, Secretary of State

2817427 8100H                        AUTHENTICATION: 0026617

                                     DATE:
<PAGE>   97


                                   EXHIBIT B


<PAGE>   98
                                                                          PAGE 1
                                State of Delaware

                        Office of the Secretary of State

                          ---------------------------

     I, EDWARD J. FREEL, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO HEREBY
CERTIFY "GENOMIC SOLUTIONS INC." IS DULY INCORPORATED UNDER THE LAWS OF THE
STATE OF DELAWARE AND IS IN GOOD STANDING AND HAS A LEGAL CORPORATE EXISTENCE
SO FAR AS THE RECORDS OF THIS OFFICE SHOW, AS OF THE FIFTEENTH DAY OF OCTOBER,
A.D. 1999.

     AND I DO HEREBY FURTHER CERTIFY THAT THE ANNUAL REPORTS HAVE BEEN FILED TO
DATE.

     AND I DO HEREBY FURTHER CERTIFY THAT THE FRANCHISE TAXES HAVE BEEN PAID TO
DATE.



                                     /s/ Edward J. Freel
[SECRETARY'S OFFICE SEAL]            -------------------------------------------
                                     Edward J. Freel, Secretary of State

2817427              8300            AUTHENTICATION: 0027211

991436097                            DATE: 10-15-99
<PAGE>   99
                                   EXHIBIT C
<PAGE>   100
                            UNITED STATES OF AMERICA

                            [STATE OF MICHIGAN SEAL]

               MICHIGAN DEPARTMENT OF CONSUMER INDUSTRY SERVICES

                               LANSING, MICHIGAN

This is to Certify That

                             GENOMIC SOLUTIONS INC.

a DELAWARE profit corporation, was validly authorized on December 12, 1997, to
transact business or conduct affairs in Michigan, and that said corporation
holds a valid certificate of authority to transact business or conduct affairs
in this State.

This certificate is issued to attest to the fact that the corporation is in good
standing in this office as of this date and is duly authorized to transact
business or conduct affairs in Michigan and for no other purpose. It is in the
usual form, made by me as the proper officer, and is entitled to have full faith
and credit given it in every court and office within the United States.


[STATE OF MICHIGAN SEAL]                In testimony whereof, I have hereunto
Sent by Facsimile Transmission          set my hand and affixed the Seal of the
                                        Department, in the City of Lansing, this
                                        28th day of October, 1999.

                                        /S/ Julie Croll, Director

174 0457943                 Corporation, Securities and Land Development Bureau
<PAGE>   101



                                   EXHIBIT D



<PAGE>   102




                                     BYLAWS
                                       OF
                             GENOMIC SOLUTIONS INC.

                            (a Delaware corporation)

                              Filed as Exhibit 3.3


<PAGE>   103

                                   EXHIBIT E

<PAGE>   104

                CONSENT RESOLUTION OF THE BOARD OF DIRECTORS OF
                             GENOMIC SOLUTIONS INC.

     WHEREAS, the General Corporation Law of the State of Delaware provides that
if all of the directors of a corporation shall consent in writing to any action
to be taken by that corporation, such action shall be as valid a corporate
action as though it had been authorized at a meeting of the directors; and

     WHEREAS, the undersigned, all of the directors of Genomic Solutions Inc., a
Delaware corporation (the "Corporation"), desire that the actions expressed
in the resolutions set forth below be taken.

     NOW, THEREFORE, the undersigned declare that the actions expressed in the
following resolutions are hereby taken by the Corporation's Board of Directors
(the "Board") as of October 11, 1999.

     AUTHORIZATION OF SUBDEBT FINANCING

     WHEREAS, the Board has determined that it would be in the best interests of
     the Corporation to offer and sell approximately $3,500,000 face amount of
     subordinated debentures with 5 year maturity (the "Debt") together with up
     to 1,400,000 warrants to purchase the Corporation's common stock (the
     "Warrants") to certain existing shareholders of the Corporation and
     potential new investors should certain existing shareholders not fully
     exercise their pro-rata rights, all collectively referred to as the Lenders
     (the "Lenders"), and

     WHEREAS, the Board has been provided with the principal economic terms
     of the Debt and the Warrants (collectively, the "Sub. Debt Financing"); and

     WHEREAS, as part of the consideration under the Sub. Debt Financing the
     Corporation will issue the Lenders warrants exercisable up to 1,400,000
     shares of the Corporation's common stock (the "Warrant"); and

     WHEREAS, up to 250,000 additional shares of common stock of the Corporation
     may, upon the election by the Lenders, be issued in respect to interest
     payments on the Debt;

<PAGE>   105


     WHEREAS, the Board has determined that it would be in the best interests
     of the Corporation and its shareholders for the Corporation to authorize
     and conduct the Sub. Debt Financing.

     RESOLVED, that the Corporation is authorized, empowered and directed to
     conduct the Sub. Debt Financing; and

     RESOLVED, FURTHER, that the Board approves the terms of the Warrant and
     hereby reserves 1,400,000 shares of authorized but unissued common stock
     for issuance according to the terms of the Warrant and hereby reserves
     250,000 shares of authorized but unissued common stock for issuance in
     respect of interest in accordance with the terms of the Debt.

     RESOLVED, FURTHER, that upon issuance against payment received in
     accordance with the terms of the Warrants or the Debt such shares of common
     stock will be validly issued, fully paid and non-assessable.

     RESOLVED, FURTHER, that the Corporation is authorized, empowered and
     directed to enter into, and to consummate the transactions contemplated in
     the Sub. Debt Financing and any and all other agreements, instruments and
     documents which relate to or are contemplated in the Sub. Debt Financing
     (the "Attendant Documents"), all as finally completed in accordance with
     these resolutions; and

     RESOLVED, FURTHER, that the officers of the Corporation (the "Officers"),
     or any of them acting alone, are authorized, empowered and directed, for
     and on behalf of the Corporation, to negotiate, prepare, finalize, modify,
     the Sub Debt Financing and Attendant Documents on such terms and conditions
     as are not materially inconsistent with the economic terms and conditions
     set forth in the terms presented to the Board, and the Officers, or any of
     them acting alone, are further authorized, empowered and directed, for and
     on behalf of the Corporation, to execute, deliver, amend and, if necessary,
     file and record with the appropriate authorities any and all documents,
     instruments and papers related to the Sub. Debt Financing and Attendant
     Documents, all as finally completed in accordance with these resolutions.

<PAGE>   106
     COUNTERPARTS; COPIES

     RESOLVED, that this Written Consent Resolution may be executed in any
     number of counterparts, each of which shall be deemed to be an original and
     all of which together shall constitute one instrument.

     RESOLVED, FURTHER, that copies (facsimile, photostatic or otherwise) of
     signatures to this Written Consent Resolution shall be deemed to be
     originals, and may be relied on to the same extent as the originals.

             [The remainder of this page intentionally left blank.]
<PAGE>   107
IN WITNESS WHEREOF, the undersigned have executed this Consent Resolution of the
Board of Directors of Genomic Solutions Inc. as of October    1999.
                                                           --

                                    /s/ Jeffrey S. Williams
                                    --------------------------------------------
                                    Jeffrey S. Williams


                                    /s/ Robert G. Shepler
                                    --------------------------------------------
                                    Robert G. Shepler


                                    /s/ J. Matthew Mackowski
                                    --------------------------------------------
                                    J. Matthew Mackowski


                                    /s/ Dan Mitchell
                                    --------------------------------------------
                                    Dan Mitchell


                                    /s/ Damion E. Wicker
                                    --------------------------------------------
                                    Damion E. Wicker


                                    /s/ Nick King
                                    --------------------------------------------
                                    Nick King