# Support Document s for

Significant New Use Rule (SNUR) on

Premanufacture Notice (PMN)

P-10-332

EPA Docket EPA

- HQ

- OPPT -2011-0577

# Index

A-001 Structure Activity Team (SAT) Report for

PMN P-10-332

A-002 Initial Review Engineering Report for

PMN P-10-332

A-003 I nitial Review Exposure Report for

PMN P-10-332

# A-001

Structure Activity Team (SAT) Report

for PMN P-10-332'ST UC UR ACTVT T AM REOR v 049



## Case #: P-i 0-0332 DCN:

SAT Date: 

## 4/16/2010 SAT Chair: 

## L. Keifer

Submitter:

Chemical Name:

CAS RN: Trade Name: 

## None
Structure

Molecular Formula:

Molecular Wt. 

### 420 WT%<500: 1T%<1000:



### MP: BP: 

## >400 1Eq. Wt:

fH20 Sol **(gIL):** 

## 0.00139 V.P. 

## <0.000001

jMax. Prod. Volume (kglyr): Physical State: 

### Liquid

FUSE:

. f n 

### Case Role Reae Cas Numbers 

## Cae ol

Date: Results: 

# Le~
7/ Page 

# 10of3

# SAT Report

PMN Number: P-10-0332

SAT Date: 4/16/2010

Related cases: Health related cases: Ecotox related cases:

Concern levels:



## Type of Concern: Health Eco Comments

Level of Concern: 1-2 3

Persistence Bioaccum Toxicity Comments

1 1

Exposure Based Review:

Health:

Ecotox:

Routes of exposure: Health: Dermal Inhalation

Ecotox: All releases to water
Fate:

P2Rec Comments:

Comment: P2REC: SAT: Forward with no comment

Keywords: Keywords: SENS-S; AQUATOX

Summary of Assessment:

Fate:

Fate Summary: FATE: Estimations for typical MW 406

Liquid with MP **< 25**  'C (E) log Kow = 

## 6.93 (E)

S = 1.39 mg/L at 25 0 

## C (E)

VP < 

## 1 OE-6 torr at **25** 'C (E)

BP > 

## 400 -C 

## (E)

H < 

## 1.00E-8 (E) log Koc = 

## 4.90 (E) log Fish BCF = 

## 2.61 (E)

## log Fish BAF =1.07 (E)

POTW removal 

## (%) =75-90 via sorption and possible partial biodeg

Time for complete ultimate aerobic biodeg = 

## wk Sorption to soils/sediments =strong

- 

## v.strong

PBT Potential: P1131

*CEB FATE: Migration to ground water = 

## negi

Health:

Health Summary: Expect poor absorption via all routes (analog). Concern

for dermal sensitization based on data for the starting

Ecotox:

Test Test Test End Predicted Measured Comments

fish 96-h LC50 0.015

daphii 48-h LC50 0.03 5

_________


### green algal 96-h EC50 0.10

__________ 

## fish chronic value 0.001 daphnid

_ 

## chronic value 0.003
algal

_ 

## chronic value 0.005

Sewage Sludge 3-h EC50

_______ 

### Sewage Sludge _Chronic 

### Value

________

__________



## Ecotox Values Comments: Predictions are based on SARs for

MW 420; liquid

with mp <-50 C; log Kow = 

## 4.90 (EPI); S =1.4 mg/L at 20 'C (P); pH7; effective

concentrations based on 100% active ingredients and mean measured concentrations; hardness

<150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 1 (ppb)

SARs

___________________phenol-amines 

## SAR Class

Ecotox Factors Comments:

SAT Chair: L Keifer 564-8916

## ~NCSAB SAT REPORT

PMN: P-i10-0332 

## ICAS RN: Non(

Chemical Name: Analogs:

Production Volum

Structure:

Formula: 1Eq Wt:

Mol Weight: 419.65 Wt%<500: Wt%<1000

MP: B1P: >400 VP: <0.000001

H2O Sol **(gIL):**

______ 

### 0.00131Physical State: LiquidLo :65 

## Endpoint (mgIL) Est. Value Meas. Value Comment
Fish 96-h 0 o 

## -7-- Daphnid 48-h 

## 3 74 -D,1

Algal 96-h ,1 D) 2L__

___ __ 1_

__ 

## Fish ChV 

# 'o)CLO- 

# O **o/**

Daphnid ChV 0,00So 0c0 o0o07 

## o' 003 Algal ChV 6 O,0Co5 01-1t 0 ':

BCF______



## CHEMICAL CLASS: ISAR:



## ECOTOX CONCERN (HJ M IL ICONCERN CONCENTRATIG 

# 06

DATE /.( j ASSESSOR:

.

### OPPT STRUCTURE ACTIVITY TEAM (SAT) MEETING DATE JJ/

ATTENDEES SIGNATURE

CHEMI STRY

__Paul Bickart

__________

__Diana Darling

__________

__Rich Engler

_________

__Greg Fritz

_ _ _ _ _ _ _ _

_ 

### Daniel Lin 

# IIIKathy Schechter
L,-,Richard Fehir 

# 1LJustnR be~~

__ __

_



### ENVRONENTL FATE

__Bob Boethling

_________

__Jed Costanza

__________

__Wen-Hsiung Lee___

________

__Laurence Libelo__

_________

__David 

### Lynch

___Andy 

### Mamantov



### HEALTH

izc t 

### herine Anitole

: MihaelCimino

-'Steve 

### Cragg

__Leonard Keifer

___________ David Lai

_________ 

# lZJim Murphy

~Ronald Ward 

## ~-Yin Tak Woo

__ __ __ __ __

__



### ENVIRONMENTAL EFFECTS

;;e'Krdon Cash

__Jeff Gallagher__

________

__Maggie Johnson__

________

__Sara Pollack

__________



### SAT CHAIR/OTHER

Rebecca Jones
kILeonard Keifer

__Jim Kwiat "or__

__ _ __

_

# A-002

Initial Review Engineering Report

for PMN P-10-332INITIAL REVIEW ENGINEERING REPORT



### PMN: 10-0332

Focus Ready Draft 4/29/2010



## ENGINEER: Choudhary 

# \ BCS/CLM

PV (g/yr: 6,00,00 YXDOES

ON SUBMITTER:

USE:

OTHER USES:

MSDS: Yes Label: No

Gen Eqpt:

Respirator:

Health Effects:

TLV/PEL:

CRSS

Chemical Name:

S-H20: 0.00139 g/L @

VP: l.OE-6 torr @

MW: 420.00 W<500 t<1000 Physical State and Misc CRSS Info:

Neat: Mfg: Proc/Form:

End Use: The structure shown on page

1 of this report is representative.

Submitted Data:
Solubility in MEK = 600 g/L (Sub. Est.); Flash Point = 220 0 C; Viscosity = 1600

cps; Density = 1.06 g/cc; Hydroxyl Number = 540 mg KOH/g; Acid Value = 17 mg
KOH/g. The IR and UV/Vis spectra are included in the PMN submission. Estimated

Data: BP = 555 OC (EPI); VP l.OE-13 torr (EPI); WS =0.00139 g/L (EPI); logP

=6.93 (EPI).

Consumer Use: No

SAT (concerns) (04/16/2010):

Related Cases and Related Cases and Misc SAT Info:

Migration to groundwater: Negligible

PBT rating: PlBlTl

Health: 1-2 Dermal, Inhalation

Eco: 3 Water (All releases to water with a CC =1 ppb)

### OCCUPATIONAL EXPOSURE RATING: 2-3C

NOTES & KEY ASSUMPTIONS:
Generated by the 

### 06/07/2005 version of ChemSTEER.

POLLUTION PREVENTION CONSIDERATIONS:

P2 Claim:EXPOSURE-BASED REVIEW:INITIAL REVIEW ENGINEERING REPORT

PMN: 10-0332

Manufacturing:

Number of Sites/ Location:

Days/yr:

Basis:

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

IRER Note: The daily releases listed for any source below may coincide with
daily releases from the other sources to the same medium.

Output 2:

to:

from:

basis:

Output 2:

to:

from:

basis:

Conservative:

to:

from:

basis:

RELEASE TOTALOCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes:

Basis:

Inhalation:

Dermal:
Exposure to High End:

Number of workers (all sites) with dermal exposure: Basis:INITIAL REVIEW ENGINEERING REPORT

PMN: 10-0332

Processing:

Number of Sites/ Location:

Days/yr:

Basis:

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

IRER Note: The daily releases listed for any source below may coincide with
daily releases from the other sources to the same medium.

High End:

to:

from:

basis:

Conservative:

to:

from:

basis:

Output 2:

to:

from:

basis:

Output 2:

to:

from:

basis:

RELEASE TOTALOCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes:

Basis:

Inhalation:

Dermal:

Exposure to High End:

Number of workers (all sites) with dermal exposure:
Basis:

Exposure to High End:

Number of workers (all sites) with dermal exposure:
Basis:INITIAL REVIEW ENGINEERING REPORT

PMN: 10-0332

Use:

Number of Sites/ Location:

Days/yr:

Basis:

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources to the same medium. Releases during spray application were not assessed.

Conservative:

to:

from:

basis:

High End:

to:

from:

basis:

RELEASE TOTALOCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes:

Basis:

Inhalation:

Exposure to
Upper Bound:

Number of workers (all sites) with inhalation exposure:
Basis:

INHALATION MONITORING DATA REVIEW

1) Uncertainty (estimate based on model, regulatory limit

or data not specific to industry) : Yes
2)a) Exposure level > 1 mg/day? Yes

OR

b) Hazard Rating for health of 2 or greater? 1-2 No

Inhalation Monitoring Data Desired? Yes (both criteria met)

Dermal:

Exposure to High End:

Number of workers (all sites) with dermal exposure:
Basis:CALL BY: Brandon Smith Organization: ERG for CEB

CALL TO:

Organization:

Date: 04/21/2010

Time: 4:50pm

Phone:

PMN: 10-0332

# A-003

Initial Review Exposure Report

for PMN P-10-332

### 4/28/2010 Page 1 of 6



## INITIAL REVIEW EXPOSURE REPORT (IRExR)

Chemical ID: P-10-0332 Reviewer: Flessner/SD

Results Table: Dose, Concentration, and Days Exceeded Results Summary

Exposure

Scenario 1 Water Landfill Stack Air Fugitive Air

Drinking Water Fish Ingestion

ADR LADD ADR LADD 7Q10 4

CC = 1 PDM
Days

Exceede

d LADD ADR LADD ADR LADD

Release
activity(ies) 2

; exposure calculation(s)

3 mg/kg/day mg/kg/day mg/kg/day mg/kg/day μg/l # Days mg/kg/day mg/kg/day mg/kg/day mg/kg/day mg/kg/day

Use: max

acute eco

Use: PDM1



### 1 Exposure scenario titles consist of release activity followed by exposure calculation abbreviation.

2 Release activities are from engineering report's Manuf acturing (Mfg), Processing (Proc) and Use release activity labels. Multiple release activities are combined in one exposure scenario if their releases occur at same location.

3 Exposure calculations are Acute Dose Rate (A DR), Lifetime Average Daily Dose (LADD), and

Probabilistic Dilution Model (PDM). There may be one, two, or all three exposure calculations per exposure scenario. CC is the aquatic concentration of concern.

4 This column displays concentration values for the 7Q 10 streamflow, which is defined as the average daily

streamflow of the seven consecutive days of lowest flow within a ten year period.



## Fate test recommendations?: OE CD 303A simulation test, with fa llback of ready biodegradation
test if simulation te st cannot be done.

### 4/28/2010 Page 2 of 6

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P-10-0332 Assessor: Flessner/SD

ENVIRONMENTAL RELEASES

Scenario#:1 Number of Release Sites:

Release Activity: Use: Max ADR

Release Description: WATER LANDFILL

Non-sludge/Sludge STACK FUGITIVE

Total Releases:

(kg/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge

Release Days/yr:

Per Site Release:

(kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:

### 4/28/2010 Page 3 of 6

INITIAL REVIEW EX POSURE REPORT

Chemical ID: P-10-0332

### 4/28/2010 Page 4 of 6

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P-10-0332 Assessor: Flessner/SD

ENVIRONMENTAL RELEASES

Scenario#:2 Number of Release Sites:

Release Activity: Use: PDM1

Release Description: WATER LANDFILL

Non-sludge/Sludge STACK FUGITIVE

Total Releases:

(kg/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge

Release Days/yr:

Per Site Release:

(kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:

### 4/28/2010 Page 5 of 6

INITIAL REVIEW EX POSURE REPORT

Chemical ID: P-10-0332

### 4/28/2010 Page 6 of 6

INITIAL REVIEW EX POSURE REPORT

Chemical ID: P-10-0332