# EPA Reg. No. 264-380 Vol. 1 (this file does not include records prior to 1991)

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### 8. Expedited Roveiw. In accordance with F1FRA Section 3(c)[3)

## ~~6~~~~PSclence [bUn, my product is similar or identical in composition and labeling

. 12014,2T.W. Alexander Drive to: Triangle Park, NC 27709 EPA Reo. No. 

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# [2] Ame!ldment· Explain below. fine! printed rob.ls In repeonn r. Aglnoy Inll,delOIt R

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- bplltin botew. Othe,· Exploin billow. Explanation: Use additional pallalsi it nlclSury. tFor sactlon t and Siciion 11.1 REGFEE: Amendment to Roglitrntion

- Regtstration ofAlternate**Confidon~1I1** Stalements0/Formula {CSFs), Fasttrack. FEE: NotApplicable. JUSTIFICATION: Tho proposed Altomale CSFsmnecl eitheremend,montsto theCSFforthe MUP, Basa 250 {EPAReg. No. 264-5(1), Ofthe use01 new MUPS/Ofwh!ch Applications lorRl.'{llstrotionJAmendmenls arcbeing submittedconeummUy with this submission. No new dataroquired rorlheproposed amendmenlto the subject end use producl·rely on existing data onIile althoEPA No**cha~e** madlliolIle composition ortheend usu product Detailed**iust~'Jcations**providad In tho attached letter. CONTACT; DanlelteA lllroclleHo, 9191549-27t8; IlM311: Oonlelto.larochetle@bayorCl'Opscleneo.ccm.

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# I T,lephoraHo. {lnctudo Aro. Codol Daniello A. Larochelle RegistraUon Manager, Insecticides (9(9) 549·27IB ; •••:. Certification s, Oato 'ppliution Illonify that tho statlmentsI hllvo mlldo on thl$ rarm Ind ett attachmonts thoroto ara true. accurlto end 

# , AoceilAt'·•• tecknowledgt thot ony knowlinQlly lelu Irmistu.dinQ statMllntmaybo p!.Inishabto byfinl IrimpritoMlent

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## • Registration Manager, Insecticides 

## • •• •••• 

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## •••• Danielle A. Larochelle September 17. 2004 

### • 

## • •••• fPA Form

..70·' ,.". ,.94) ata ob,oIetd. Whit.

- EPA Fa. Copy 

# 3

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# "
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# •

• BayerCropScience

November 5, 2004

Docunlcnt Proccssillg Desk (WD) Office ofPesticide Programs (7504C) 

### U.S. Environmental Protection Agency 1801 South Bell Street Arlington, Virginia 22202-4501 AttentIon: Ms. Linda Arriuglon, RD



### Dear Ms. Aninglon, 

### Rc: Withdrawal ofApplications for Pesticide Amendment End Use ProductsContaining Ethephon On September ]7, 2004 BayerCropScicncc submitted several applications for 

### pesticide amendments for end 

### IISC products

### containillgthe active 

### ingredient Elhcphon. The proposed amendments reflected 11) changes which are notyet approved forthe muuuf.1cturing 

### usc product Base 250 Confidential Statements ofFormula (CSFs) and b) the usc ofmanufacturing use products which arc not yet registered. Base 211 Ethephon and Ethephon Manufacturing Concentrate (applications also submitted 9/17/2004). 

### We arc therefore withdrawing the applications submitted for the following end usc products:

ETHREL® brand Ethephon Plant Growth Regulator (For Pineapple and

Sugarcane)

- EPA Reg. No. 264-257 FLOREL® bmnd Ethephon flam Growth Regulator

- EPA Reg. No.**264~263** 

### ETHREL® brand Ethephon Plant Regulator

- EPA Rcg. No. 264-267 CERONE® brand Ethephon Plant Regulator**~** 

### EPA Reg. No. 264-377 PREpTM brand Elhephon Plam Regulator for COllon

- EPA Reg. No. 264-380 PREpntbrand Elhcphon for Cotton and Tobacco

- EPA Reg. No. 264-4If! FLOREL® brand G/R Plant Growth Regulator

- EPA Reg. No. 264-543 FINISHrID 6 PRO Harvest Aid for COItOIl

- EPA Reg. No. 264-703 Foryourconvenience, copies oftlte Applications for Pcsticide Amendment (EPA Form 8570-1) submitted on September 17

# ror these products are attached for reference. Please schedule the review ofthe Ap]llications submitted on September I

### til proposing CSr: 

### umClldmellts for Base 250 and the registration ofthe new
//2


# 4

# , •



# • November5,2004 Ms. Linda Arrington 

### Pagc2of2



### Withdrawal ofApplications for Pesticide Amendment (Cont'd)

manufacturing use producls, Base 2J J Ethcpholl and Ethephon Mnnufacturing Conccmrate. Ollce these actions arc completed, the amendments for the producls listed nbovc will be**rc~submittcd.** Please 

### Jet meknow ifyollnced allY additiooal information. You can reach me at (9J9) 549-27J8orby e-mail at**n:lnieJ.!f~1mchcJk!l1**

### bavercrQ!1,l:jcncc.cmn. Sincerely,

Danicllc A. Larochelle Registration Product Mallager

cc: Ms. Cynthia Giles'Parker. 

### RD/PM22

Attachments

COrT. No. daL112·04



# 5**~---------~~~~~~~~** 

## ------------------ 

# • -'



# • BayerCropScience

November5, 2004



### Document Processing Desk(WD) Office ofPesticide Programs (7504C) U.S. Environmental Protection Agency 

### 180I SouthBeU Street Arlington, Virginia 22202-45Oi Attention: Ms. LindaArrington, RD



### Dear Ms. Arrington, Rc: Withdrawal ofApplIcations forPesticide Amendment EndUse Products ContainingEthcphon 8IJfi>' [:1

..",50"",* RTF ;:- 0 lb.' 1"'.11.; PTF. t;C :;.,,08 Td !i1&f4S":'Don 

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## c, 350, On September 17,2004 8aycrCropScicncesubmitted several applications forpesticide amendments forend uscproductscootaining the active ingredient Ethephon. The proposed amendments reflected a) changes which 

### are notyet approved forthe manufacturing usc

### productBase 250 Confidential Statemeots ofFonnula (CSFs) and b) the uscofmanufacturing use products which are not yetregistered, Base2 I I Etllcphon and Ethephon ManufacturingConcentrate (applications also submitted 9/i7J2004). Wearc therefore withdrawing the applications submitted fOf the folJowing cnd use 

### O'f' I',"'it

## ~ products: 

## trc*'io V\ 

## l.J**;:d.r-c.:.w~-** 

# /lJD3SI1l7?/S771'J 19
FLOREL® brand Ethephon Plant GrowthRegulator * EPA Reg. No. 264*263 

## 'D3'SI

## "i!73fs771Y 2..0 ETHREL® brand Ethephon Plant Regulator*EPA Reg. No. 264·267 D .3

## S I"'Z' 7

### ~ / S 77\ l{

### 2.\ CERONE®brand Ethcpbon Plant Regulator * EPA Reg. No. 264·377 1).3

## S'\ 

## 'is7 

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## ':2

## 2.. PREpTM brand Ethcphon Plant Regulator foreolian * EPA Reg. No. 264*380 

### i)3S'

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## 7b/.:s77

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## 3 PREpThl brand Ethephon for Cotton and Tobacco *EPA Reg. No. 264-418 

## D3S

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# s 771 L.{

# 2.L{ FLOREL® brand 

### GIR Plant Growth Regulator- EPA Reg, No. 264*543 

## D3S1

## '1S 7'ft/ S 77/L/2

## S FfNISH® 6 PRO Ilarvcsl Aid for Colton * EPA Reg. No. 264-703 D 

## 35"/157 

## '1/5:7 71 Lj 

## 2. t;; 

## S e"7 • ETHREL® brand Ethephon PlantGrowth Regulator (ForPineapple and C0'V\ • Sugarcane) ** EPA Reg. No. 264·257

For yourconvenience, copies ofthe Applicatioos for Pesticide Amendment (EPA Fonn 8570*I) submitted on September 17 for these products arc attached for reference.
Please schedule thereview oftbe Applications submitted on September 17!h proposing CSF amcndmcnts for Base250 and**~le** registration ofthe new 

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# •

• November5, 2004 

### Ms. LindaArrington Page 2 of2



### Withdrawal ofApplications for Pesticide Amendment (Cont'd)
manufacturing use products, Base 211 EthepllOn and Ethephon Manufacturing Concentrate. Once these actions are completed, the amendments fot the products listed above 

### will be re-submitted. 

### Please let me know if

### you need any additional infonnation. You call reach me at (919) 549-2718 or by c-mail at Danie!Jc.Laroclie!!c(whllvcrcropscic!!cc.com. 

### Sincerely,

DameIIe A. 

### Larochelle Registration ProductManager

cc: Ms. Cynthia Giles Parker, RDlPM22

Attachments

Corr. No. daLl 12-04

, ,v< 

# 7

# •

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### 5,**~004**

DO(.'Il!nl.'lli I'roC<.!SSI11¥**Do.:~k** (WDj OllieI.' ofPe;;(icidc Prognl!lls (7504('] 

### U.s. Elwironlllt:llt:lll'rolcclioll AgclH.:Y IIW I South B.::l1 Street Ari(l(ghHI. \,irgil!'111 n:::!(),2-4501 

### Altcntiol1; Ms. Linda Alring-t((lI. RD

Dear \{.;. Arrington. 

### Re: Wilhdnlwal ofAppJiClltilllls ((\t. 

### Pesticide A1l1CJldI11l'Ut End Usc Prod11cts Containing EthcpllOll
On Seplenlhcr Ii, 1004 B:I)wCropSt;icllce suhmiltcd sc\"cral III)piicati((lIs for pes1icidc amendments fiJr cl1d lise prOilliCb containing the active ingrediellt Ethcphon.**Th~'** proposed 

### arlltlldlllcnts reflected a) 

### c1wllgcs \l'IJich 

### are not yel**<lppron~d** 

### for 111(: 

### (J111llufllcluring (lSI.' prodncl Base 250 

### Confidential SialCI11Cl11

### sorF orlllul:l 

### (CSFs) alld 

### b) 1111.' usc oflnalllliac(uriIIg 

### ((SC product.>: which :11"1.' nOl y<.!l 

### rcgislcrcd. Base**~II** 

### Elhcrlmlllll(d Edlcrllnn \1,lIlUfllclUring**COII~'entn!1C** 

### (lIpplic.l1iolls Illso sllbmiued 91

### I7/2004). \\\' arc lhcrcforc withdnnrillg the IIpplitali((ns sllhmillcu lor lile**foll,~wing** 

### cud lise proJlIcts:

ETI-IREJ}).t: brand Elherl(((ll PI;!lll (jrowlh Regulator IFor PilH:applc alld

Sugarcalle)

-- EPA Reg. No. 264-257 FLORELR brllild 

### ElhepllOll Plall1 Growth RegUlator

- EPA Reg. 1\1). 

### 264-263 ETI-IREIA> hr<l(Iu Etl(Cpl(!(I( l'hlill Rcgllialor

- EPA Reg. N(1. 264-267 CERONbirhmnd 1:1hepl1((11 Plant Reguilitor- EPA Rl.'g. No. 264-377 I'!tEp a1 

### hral(d Ethephon Pbn(**R~'g(\lator** 

### fiJr ('011011- 

### EPA Reg. No. 2M-3XO PREI'r.-., hrand EthqdlOli l'orCotWn ,md Tohacco

- EPA Reg. 1'\0_ 

### 264-41 S**FLOIU~U\'** 

### br<IIIJ (ifR 

### Plant Growth Rcgu];ltor

- EPA Reg. No. 1M-54} 

### FINISlld('6 PRO I-hlrvcst ,\id forCouml

- EPA Reg. 1\0. 

### 264-703 For youreonvcnkncc, C\lpk's uJ"11le APJ11k;(tioll;; for Pesticide**:\l1lcndm~'1l1** 

### (EPA F((nll :-557((·1) 

### S(lhlllillcd Oil 

### SC]llcmber 

### J7 n(r**th~·"e pro(hl~'IS**  

### arc allachcd for**rcf~'rcnCl·. Pkas~'**  

### SdlCUlik thc rCI iell' orthe AppliCfltiollS slIIJlllillCd ((11 

### Se)ltCIl1IICr I

# r:' pruposil(,!!. ('SF ,IIlIClhlll1cnlS fox Base 250 ;md lhl.! rcgislrali(]11 oftln: new



# 8

# •

., Nlwcnlher S, 1004**~h.** Linda Arl"ingh11l 

### Page::!**Dr~**



### WfthdntwaJ ofApplicaHulIS f(lr 

### Pcstidd(> 

### Amcndmcill (Cont'd)

rnallur:I\"nlflllg us!: pro\l(l\'\S, 

### Bas..: 211 l:thcphull <lIlU 

### Etllcphnll \1f1lluliwlOring COIl(:CllIrUle. 011(.'\' 

### these actiDns 

### <1n: t::ompio.:!cd. tlte anu.:numcncs I'm tIlt jlf<.lUlICIS 

### listed <lbvvc will be rc-suhlniucd. 

### Plc<lSC kl 

### me kuow**IrYlllllli:~·d <I(l~**  

### additional ilirmlll;ulmL 

### '{ou C,lll**n~adl** 

### Olea! i()lqj 5·l9-27IR or h} C

-Ill;)

### i1a! Ui.!I]]yllL**L,'.!!..~')**J!dk**~!iJ;;!..;**fl**O'X'}l'.~,S I"')J~~**  __**<;!2.~!i** • Silll.:crcly.



### Danicllc A. 

### Larochelle Rcgislr,J(ioll I'rO(hll.:l ;v1:lnagcr



### cc: /I.'Is.. 

### Cynthi:! Giles Parker. RJ).'PM22

AIWclUJICOIS

COlT. No. JnL I**)~+!l.j**



# 9OM", 

# &EPA Unitod StOtO, 

# ti: Registration 

# IoPP Identifier Numbor 

### Environmental Protection Agency Amendment Washington. DC 2046{) 

### Other

,for 

# , ,- 

# , , I 

# '.' 2. EPA Product Meneger Classificotion

.Cynthia Giles-Parker DNone 

# o Rastrictlld 4. , 

# " ••m.' PM' Colton Team 22 5. Nom., ond Address 01 Applinn! (Ine/!Jdll ZlP Cod., 

### 6. Expedited Reveiw. In accordance with AFRA Section 3(cJl3)

## ~:6:;,ox-120'4.,2-Tw 

# NC27709 Ibllil. my product is similar or identical in composititln and**labe~no** to: EPA Reg. No. 

# o Checkiftill$ is It MWIIddft/:S Product Name



### ,- II
Amondmont· ExplaIn b.tow. 

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# o Ageneylouerdatod -Me Too· Applicetio". 

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0 NoliUcolien' Explain below. 

# o Other· Explain bolow. Explanation: u"o odditional pogal.) trnoc"lIUry. IFor nction t ond Section tt.l REGFEE: Amendment 10 Registration

- ReGistration 01A1temate COfIfidantial Stalemenls01 FOI'mufa (CSFs). Fasl track. FEE: Not Applicabl(l. JUSTIFICATION: The proposedA1temate CSFs reOeet ailhOfllmandmenls 10 tho CSF lorthe MUP, Baso 250 (EPAReg. No. 264.5(1).ortheuse ofnew MUPs (orwhichApptlcaUOflS!ofR09isITaiion/AImlndmeniS aro baing submittedconcurrentlywilhthis submission. No nowdala required for tho proposed Grnono'monl to thesubJectend usa producl- rely on existing data on me altho EPA. No chango mado 10 tha composition 01 tha end usaproduct. Debiled**iusti~C9tlonS** plovtdadIn Iheattached !ottar. CONTACT: DanletloA.larocl1eHe, 919/549-2118; eMait: DanleUe.larochetle@bayercropsc/onco.com.



### , - III 

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1,. i**.~.** 11•• Tolophono No, ilneJl",,.w Codol

Oanielle A, Larochelle Reglslralion insectlcldes {919}549-21t8 

## • Certffication •••:

# I~ Iconilv thll tho slltemonls I hln mlldo on this form and all,ttlchmlnts thorllo 01'11 true, occurale and compleQt. 

### • t ocknowt&dgo that enyknowtingHy fain ormide&dinO $I0tlment mev be punishabto by fine or imprbonment or • (Stamped) bolh 

# 2.,;,0'''''

# W{1t{ /l { (I/ill 3.Tiue 

# . I': • " 

### • • 

## • Registration Manager, Insecticides 

# ": I'

. •••• 

## • •**.~.** 5.0eta 

### •••• • 

## •

.,

# .. Danielle

### A. Larochelle 

### September 17, 2004 •••• 

## • EPA FMm 8510·' ,.". '·94) i , 

# ... W1>It, -, 

# ,,,,,,InO' 'Cooy 

# 10

## ••••• • 

## NOTREVIEWEIJ. :::: In

### Accordance with PR**Nt>l\c~**

# B2{i: 

# PRE pTM 

# brand Ethephon PLANT REGULATOR FOR COTTON Based on Draft Labeling Dated •

FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. NOT FOR RESIDENTIAL USE. ACTIVE INGREDIENT, 

# !7d7- ;?

### ""c".7.- 

## • I.

## • 

## • •

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# • • • • 

# • • • • • • 

# ·
. 

# ·

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## •

•

Ethephon (2-chloroethyl) phosphonic acid"

........,............................................................................................39.9% INERT INGREDIENTS' •...................................•...•.•.•.•.•.•.•.•...•.........•....•......••..•..........•.•.......•...............................•.• 60.1 

### % -This product contains 4 pounds elhephon per galion. 

### EPA Reg. No. 264-380 EPA Est. No. 264-PA-Ol 

# • KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
Si usled no enliende la eliqueta, busque a alguien para que sa la explique a usled en detalle. (If

### you do not understand the Jabel, find someone to explain it to you in detaiL) For MEDICALAnd TRANSPORTATION Emergencies

## 2N.LY Call 24 HoursA Day 1-800-334-7577 

### For PRODUCT USE Information Call1-866-99BAYER (1-866-992-2937) 

## • • • • • • • • •



## •

The use of this product for a variety of plant growth regulaUon uses Is covered by United States and foreign patents Including U.S. Patent 4,240,819. No llcense is granted to use this product in countries other than the United States or for any use not contemplated by this label. Liability for patent infringement may result from use orsale ofthis product outside the United States. 

# FIRSTAID IFtN EYES: 

## • Hold eye open and rinse slowly and gentlywith waterfor 15·20 minutes. 

## • Remove contact lenses, if present, afterthe first 5 minutes, then continue rinsing eye. Call a oo;,on control cenlerordoclor' I ad,;ce. IFON SKIN OR 

## • Take offcontaminated clothhg. CLOTHING: 

## • Rinse skin immediatelywith plenty ofwaterfor 15·20 minutes.

,. Call a Do;,on conlro' , rdoclor' Iad';ce. SWALLOWED: 

## • Immediately call a poison control center ordoctorfor treatment advice. 

## • Do not induce vomiting unless told to do so by a polson control centeror doctor. 

## • Have person sip a glass ofwater ifable to swallow. 

### • Do not, Iby mouth 10 an , Deo;on. For MEDICAL Emergencies Call 24 HoursA Day**1~800-334-7577.** Have tho Iw;!h YOU when II NOTETO PHYSICIAN, Treat symptomatically. Consideration should be given to the possibility that overexposure to materials otherthan this may have occurred. No specific antidote Is available. Probable mucosal damage may contraindicate the 

# PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANSAND DOMESTIC ANIMALS Corrosive. Causes Irreversible eye damage and skin irritation. Harmful ifswallowed or absorbed through skin. Do not get in eyes, on skin, or on clothing, Harmful orfatal if swallowed. Avoid contamination offood.



# 11 • • • 

# • ••• 

## • •

### PERSONAL PROTECTIVE EQUIPMENT (PPE) Applicators and other handlers must wear rong-sleeved shirt and rang pants, chemical resistant 

### gloves**mad~** of <!ny waterproof material (such as Nitrile, Butyl, Neoprene andlofBarrier Laminate), shoes plus socks and protective eyewear. • • When handlers use closed systems, enclosed cabs, or aircraft In a mannerthat meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides 140 CFR 170.240 (d) (4-6)], the handler PPE requirements may be reduced or modified as specified in the WPS. Discard clothing and other absorbent materials that have been drenched Of heavily contaminated with this product's concentrate. Do not reuse them. Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructionsforwashables, use detergent and hotwater. Keep andwash PPE separately from other laundry. 

### UserSafety Recommendations Users shouldwash hands before eating, drinking, chewing gum, using tobacco or using the toilet Users should remove clothing Immediately if pesticide gets inside. Then wash thoroughly and puton clean clothing. Users should remove PPE immediately after handling this prOduct As soon as possible, wash thoroughly and change into clean clothing. Wash the outside ofaloves before removing: 

### ENVIRONMENTAL HAZARD

• VOld spray drift

### to nearby crops as this product may cause temporary modifications in plant growth. Do not contaminate water used r irrigation ordomestic purposes. Do not apply dlrectry towater, orto areas where surfacewater is present orto intertidal areas belowthe mean high waler mark. Do not contaminate water when disposing ofequipmentwashwaters. Do notexceed the rate of PREpThl brand EthephOn Plant Regulator for Cotton per acre peryear recommended on this label. 

### SPRAY DRIFT Avoid spraydrift. Do not applywhen weather conditions may cause drift. Do not allow this product to drift on to non-target areas. Drift may resurt in illegal residues or injury to adjacent crops and vegetation, in the form of teaf yellowing and defoliation. To avoid spray drift, DO NOT apply aerially when wind speed Is greater than 10 mph or during periods of temperature inversions. Use of larger dropletsizewill also reduce spray drift. AVOIDING SPRAY DRIFT ATTHE APPLICATION SITE IS THE RESPONSIBILITY OFTHE APPLICATOR. The interaction of manyequipment-and-weather-related factors determIne the potentialfor spray drift. The applicator is responsible for considering allthese factors when making decisions. The following drift management requirements must be followed to avoid off-target movement from aerial applications to agricultural field crops. These requirements do not applyto forestry applications, public health uses or

### to applications using dryformulations. 1. The distanceofthe outer most nozzles on the boom must notexceed 

### 3/4 the length ofthewingspan or rotor. 

# e Nozzles mustalways point backward parallelwith the air stream and never be pointed downwards more than 45 degrees. Where states have more stringent regulations, they should be observed. The applicator should be familiar with and take into accountthe information covered in the Aerial Drift Reduction Advisory below: 

### AERIAL DRIFT REDUCTION ADVISORY [This section is advisory in nature and does notsupersede the mandatory label requirementsj. INFORMATION ON DROPLET StZE The most effective way to reduce drift potential is to apply large droplets. The best drift management strategy is to apply the largest droplets that provide sufftcient coverage and control. Applying larger droplets reduces drift potential, but will not prevent drift if applications are made improperly, or under unfavorable environmental conditions (See Wind, Temperature and Humidity, and Temperature Inversions). CONTROLLING DROPLET SIZE Volume

- Use high flow rate nozzles to apply the highest practical spray volume. Nozzles with higher rated flOws produce larger droplets. Pressure

- Do not exceed the nozzle manufacturer'S recommended pressures. For many nozzle types lower pressure produces larger droplets. When higherflow rates are needed, use higherflow rate nozzles instead of Increasing pressure. Numberof nozzlas

- Use the minimum numberof nozzles that provide uniform coverage. Nozzle Orientation

- Orienting nozzles so that the spray is released parallel to the airstream produces larger droplets than other orientations and is the recommended practice. Significant deflection from horizontal will reduce droplet size and increase drift potential.


# 12Nozzle Type· Use a nozzle type that is designed for the Intended application. With most nozzle types, narrowerspray angles produce larger droplets. Consider using low-drift nozzles. Solid stream nozzles oriented straIght back produce the largest droplets and the lowest drift. 

### BOOM LENGTH For some use pattems, reducing the effective boom length to less than 3/4 of the wingspan or rotor length may further reduce drift without reducing swath width. APPLlCATtON HEtGHT Applications should not be made at a height greater than 10 feet above the top of the target plants unless a greater height is requIred foraIrcraft safety. Making applications atthe lowest height that is safe reduces exposure ofdropletsto evaporation and wind. SWATH AOJUSTMENT When applications are made with a crosswind, the swath will be displaced downwind. Therefore, on the up and downwInd edges of the field, the applicator should compensate for this dIsplacement by adjusting the path of the aircraft upwInd. Swath adjustment distance should Increase, with Increasing drift potential (higherwind, smaller drops. etc.). WIND Drift potential Is lowest between wind speeds of 2 • 10 mph. However, many factors, Including droplet size and equipment type determine drift potential at any given speed. Application should be avoided below 2 mph due to variable wind direction and high inversIon potential. NOTE: Local terrain can influence wind pattems. Every applicator should be familiarwith local wind pattems and howthey affect spray drift. eEMPERATUREAND HUMIDtTY When making applications in low relative humidity, set up equipment to produce larger droplets to compensate for evaporation. Droplet evaporation is most severe when conditions are both hot and dry. TEMPERATURE INVERSIONS Applications should not occur during a temperature inversion because drift potential Is high. Temperature inversions restrict vertical air mixing, which causes small suspended droplets to remaIn in a concentrated cloud. This cloud can move in unpredictable directions due

### to the light variable winds common during inversions. Temperature inversions are characterized by increasing temperatures wIth altitude and are common on nights with limited cloud coverand light to no wind. They begin to form as the sun sets and often continue Into the morning. TheIr presence can be indicated by ground fog; however, iffog is not present, inversions can also be Identified by the movement of smoke from a ground source or an aircraft smoke generator. Smoke that layers and moves laterally In a concentrated cloud (under low wind conditions) Indicates an inversion, while smoke that moves upward and rapidly diSSipates indicates good vertical air mixing. SENSITIVEAREAS The pesticIde should only be applied when the potential for drift to adjacent sensitive areas (e.g. residential areas, bodies of water, known habitat for threatened or endangered specIes, non-target crops) is minimal (e.g. when wind Is blowIng away from the sensitive areas). 

# DIRECTIONS FOR USE 

# e It Is a vIolatIon of Federat taw to use thIs product In a manner InconsIstentwith Its labeling. Do notapplythts product In a waythatwill contact workers orotherpersons, eItherdirectlyorthrough drift. Only protected

handlers may be In the area durIng applicatIon. Forany requIrements specifictoyourState orTrlbe, consult the agency responsIble for pesticIde regulatIons. Road enUre label before using thIs product. 

### AGRICULTURAL USE REQUIREMENTS Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR part t70. This standard contains requIrements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural pesUcides, It contains requirements for training, decontamination, notification, and emergency assIstance. It also contains specific Instructions and exceptions pertaining to the statements on this label about personal protective equipment (PPE), notification to workers and restricted-entry interval. The requirements in this box only apply to uses ofthIs product that are covered by the Worker Protection Standard. Do not enterorallow worker entry into treated areas during the restricted-entry interval (REI) of48 hours. The REI is 72 hours in areas where average rainfall is less than 25 Inches per year. PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated such as plants, soli or water Is coveralls over long-sleeved shIrt and long pants, chemical resIstant gloves made of any waterproof material, such as nitrile, butyl. neoprene, or barrier laminate, chemical resistant footwear plus socks, and protective eyewear, For overhead exposure, chemical-resistant headgearis also required. Notifyworkers ofthe application by warning them orally and posting waming signs at entrances to treated areas.



# 13

### STORAGE AND DISPOSAL Do notcontaminate water, food, orfeed bystorage or disposal. PESTICIDE STORAGE Store in a cool, dry place and away from food, feed and other pesticides. IF SPILLED: Ifcontainer is broken or contents have spilled, follow all precautions indicated above and dean up immedIately. Before cleaning up, pul on full length trousers, long sleeved shirt, protective gloves, and goggles orface shield. Soak up spill with absorbent media such as sand, earth or other suitable material and dispose ofwaste at an approved waste disposal facility. PESTICIDE DISPOSAL Pesticide wastes are acutely hazardous. Improper disposal of excess pesUcide, spray mixture, or rinsate Is a violation of Federal law. If Ihese wastes cannot be disposed of by use according to Jabel instructions, contact your State Pestlcide or Environmenta[ Control I

## Ac,en,,, orthe Hazardous Waste representative atthe nearest EPA Regional Office for guidance. 

### tCC'NTJ'III'ERDISPOSAL rinse (or equivalent) the empty conta·lners. Then offer for recycling or reconcfltioning, or puncture and dispose of'ln a

# ""iI',,,,\ [ II or by incineration or ifallowed bystate and local authorities, by bumlng. [fcontainer is bumed. stay out ofsmoke. 

### RETURNABLE

-- REFILLABLE CONTAINERS use, return the container to the point of purchase or designated locations. This container must only be refil[ed with PREplM Ethephon for Cotton and Tobacco. DO NOT REUSE THE CONTA[NER FOR ANY OTHER PURPOSE. Prior to remling, inspect

I for as cracks, punctures, abrasions and damaged or worn out threads on closure devIces. Do not refill contaIners. Check for leaks after refilling and before transportation. Ifthe container is not being refilled,


### GENERAL INFORMATION A foliar spray of PREpm brand Ethephon Plant Regulator for Cotton will accelerate opening of mature unopened cotton bolls and enhance defoliation which can result in earlier harvest with an increased recoverable yield. PREP"" brand Ethephon Plant Regulator for Cotton treatment allows Increased efficiencyfrom a once-over harvest. Some premature drop of small. immature bolls may be associated with treatment. 00 not apply before suffICient, mature. unopened bolls have developed to produce the desired yield ofcotton. A boll is mature when it is too hard to be dented when squeezed between thumb and fingers. too hard to be sliced with a sharp knife, and when the seed coat becomes light brown in color. For best results, thorough and uniform spray coverage Is requIred. It is essenlialthat the bolls are contacted by the spray to obtain optimum boll opening. Observe treated fields closely. Harvest at optimum boll opening and defoliation. generally 14 to 2 t days after treatment. Sustained cold weather with average day and night temperatures of**65~F** or lower after treatment with PREP"" brand Ethephon Plant Regulator for Cotton will delay the boll opening response. DO NOT APPlY PREpm BRAND ETHEPHON PLANT REGULATOR FOR COnON IF RAIN [S EXPECTED WITHIN 6 HOURS. aainfallwithin 6 hours of application may reduce product performance.

### ~ertifled cotton seed growers should observe boll and seed maturity before treatment with PREP"" brand Ethephon Plant Regulator for Colton. Bolls not completely mature mightopen with treatment of PREP"" brand Ethephon Plant Regulator for Cotton giving lower quality seed. IMPORTANT: Do not apply PREpm brand Ethephon Plant Regulator for Cotton through any type of Irrigation system. SPRAY PREPARATION Add 112 to 3/4 of the reqUired amount ofwater to the spray tank. Start agitation. Add the required amount of PREplJ.I brand Ethephon Plant Regu[ator for Cotton, and the remaining amount of water. Prepare only as much spray solution as can be used on the day of mixing. 00 not allow spray solution to stand overnight. Do not spill the concentrated product on spray equipment, or any airplane parts. ANY SPILLS SHOULD BE RINSED IMMEDIATELY WITH PLENTY OF WATER. Use of a nurse tank is hIghly recommended for avoiding possible spillS ofconcentrated formulation on spray equipment or any airplane parts. 

### EQUIPMENT CLEANING Spraydeposits of PREpm brand Ethephon Plant Regu[ator for Cotton, when left on aircraft acrylic plastic type windshields for longer than t hour, may react with this material, forming an opaque film or spots on the surface which cannot be removed by washing with water or any other cleaner. Rinse windshields with water Immediately after each tankload of PREplM brand Ethephon Plant Regulator for Cotton has been applied. Thoroughly rinse the aircraftwith clean water after each day PREp1lI brand Ethephon Plant Regulator for Cotton Is applied. PREP'''' brand Ethephon Plant Regulator for Cotton mayalso affect certain paints. and if accidental deposits on painted objects such as cars, trucks, agricultural eqUipment. etc. occurs, these obrects should be rinsed with water as soon as possIble (within 1 hour) to prevent permanent staining ofthe painted surface. 

# 14Because of the acidic nature of this product, prolonged exposure to spray deposit will damage acrylic plastics, certain paints, and metals. Rinse thoroughly with a detergent and water all exposed acrylic plastic-type materials (e.g., aircraftwindshields), and painted surfaces within an hourafter exposure to spray deposits. Attha end ofe@ch day, rinse thoroughly with a detergent and water all the metal parts ofthe aircraft and the associated spray equipment exposed to the spray deposits. BOLL OPENING

CONDITIONS EXPECTED 5·7 DAYSAFTER

TREATMENT Hotand dry 80'F or higher Dry with temperature 75"F to 80'F Cool but higher than 6S"F Rates For Boll Oeenlng
PREpm brand EtMPhon ONE GALLON OF Plant Regulator for Cotton PREpm brand Ethephon Plant RegUlatorfor Cotion QUARTS/ACRE TREATS

1.0{1.0Iba.l.) 1.S (1.Slb a.i.)
2.0 (2.0 Ib aJ.) 4 Acres 2.S Acres
2Acres SPRAYVOLUME GAL./ACRE GROUND AIR

1S to SO 1StoSO
1StoSO 2to S2to S·

.-ankcotlon 2.0 (2.0 Ib a.L) 2Acres 25 to SO 2to 5' 5 WNOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications Time of Application (Boll Opening) Apply when there are sufficient mature unopened bolls to produce the desired yield, but no later than when 60% of the bolls are opened (see General Information section on how to test for boll maturity). Do not tank mix PREP"" brand Elhephon Plant Regulator for Cotton with a desiccant If the cotton Is to be spindle harvested.



# 15

## PRECONDITIONING FOR DEFOLIATION
Rates For Preconditioning For Dofollatlon

CONDITIONS EXPECTED 5·7 DAYS AFTER
TREATMENT Hot and dry 80'F or higher Cool but higherthan 65'and also for rank cotlon PREP'"" brand Elhephon Plant Regulator for Colton QUARTS/ACRE 0.5 (O.Slb a.l.) 1.0 (1.0 Ib a.L) ONE GALLON OF PREpTM brand Ethephon Plant Regulatorfor Cotton TREATS 8Acres 4Acres SPRAYVOLUME 

### GAL/ACRE GROUND AIR



### 151050 151050 

### 2

### to S· 2

### to**5~** ·NOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications. Tlmo ofApplication (Preconditioning) Apply PREpn> brand Ethephon Plant Regulatorfor Cotlon 410 7 days priorto application ofderoliant ortank mixed with the defoliant (see section on Compalibmty). Do not lank mix PREPn.< brand Elhephon Plant Regulator for Cotton with desiccants unless plant fteSiccation is required. Pre-treatment

### With Defoliants Prior to PREpm brand Ethophon Plant Regulator for Cotton Troatmont If the cotton is overly rank or laying down in Ihe middles and good spray coverage of the bolls with PREpTh! brand Ethephon Planl Regulator for Cotton Is difficult, 

### a pretreatment with defoliants will be useful to improve boll coverage with PREp 1M brand Ethephon Plant Regulator for Cotton. Use dosage rates of PREpTM brand Ethephon Plant Regulalor for Cotton recommended for boll opening. Read and observe all appropriate label use directions and precautions for the defoliant used. Do not use a defoliant before there are sufficient mature unopened bolls to produce the desired yield (see General Information section on howto testfor Boll Maturity). COMPATIBILITY PREpTM brand Ethephon Plant Regulator for Colton is compatible with DEF, FOLEX, DROPP, HARVADE, METHYL PARATHION, GUTHION AND MALATHION, and may be applied in sequence or as a tank mixture (DO NOT TANK MIX WITH DEFOLIANTS OR DESICCANTS IN CALIFORNIA AND ARIZONA). In some cases slight reduction in boll opening response has been observed when tank mixeswith defoliantswere used. Good agitation in the spray tank is essential and a tank mixture should not be allowed to stand without agitation for more Ihan 

### 5 to 

### 10 minutes. Read and observe all appropriate label use directions and precautions for the defoliants and insecticides used. 

### aRECAUTION, t.lOTE: UNDER CERTAIN CONDITIONS, TANK MIXTURES OF PREpTh! BRANO ETHEPHON PLANT REGULATOR FOR COTTON**~WITH** DESICCANTS CONTAINING SODIUM CHLORATE COULD RESULT IN THE FORMATION OF HYPOCHLOROUS ACIDS WHICH ON HEATING WILL EMIT TOXIC CHLORIDE FUMES. DO NOT MIX PREpTh! BRAND ETHEPHON PLANT REGULATOR FOR COTTON WITH AMMONIUM THIOSULFATE. SUCH TANK MIXTURES MAY RESULT IN FORMATION OF TOXIC FUMES. WHEN TO HARVEST: Do not harvest cotton sooner than 7 days after a treatment with PREpm brand Ethephon Plant Regulator for Colton. Observe the treated crop and harvest when optimum boll opening has been reached. Too early harvest might reduce the fun advantage of the treatment and too late a harvest may result in reduced quality and loss of lint which will drop from the plant. USE LIMITATIONS Do not exceed a maximum of 2.0 lb. ethephon active ingredient per acre per year through combined or repeated uses of any ethephon products. Boll Opening: Do not tank mix PREpTM brand Ethephon Plant Regulator for Colton with a desiccant if the cotton is to be spindle harvested. Pre-Condition for Defoliation: Do not tank mix PREpTM brand Elhephon Plant Regulator for Cotton with desiccants unless plant desiccation is required. Do not use a defoliant before there is sufficient mature unopened bolls to produce the desired yield {see General Information section on how to test for boll maturity. Do not plant another crop within 30 days after treatment. USE PRECAUTIONS 

# 16Avoid spray driftto nearby crops as Ihis producl will cause modifications in plant growth. Plant injury or reduced yields will result. Mix only the amount of spray you expect to use each day, Do not allow mixed solution to stand overnight 

### IMPORTANT: READ BEFORE USE Read the entire Directions for Use, Conditions, Disclaimer ofWarranties and Limitations of Liability before using this product. Ifterms are notacceptable, return the unopened product container at once. By using this product, user or buyer accepts the following Conditions, Disclaimer ofWarranties and Limitations of Liability. CONOITIONS: The directions for use of this prodUct are believed to be adequate and should be followed carefully. However, it is impossible to eliminate all risks associated with the use ofthis product. Crop injury, ineffectiveness or other unintended consequences may result because of such factors as weather conditions, presence of other materials, or the manner of use or application, aU of which are beyond the control 01 Bayer CropScience. All such risks shall be assumed by the useror buyer. DISCLAIMER OF WARRANTIES: BAYER CROPSCIENCE MAKES NO OTHER WARRANTIES, EXPRESS OR IMPUED, OF MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE OR OTHERWISE, THAT EXTEND BEYOND THE STATEMENTS MADE ON THIS LABEL. No agent of Bayer CropScience is authorized to make anywarranties beyond those contained herein or to modify the warranties contained herein. BAYER CROPSCIENCE DISCLAIMS ANY LIABILITY WHATSOEVER FOR SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. LIMITATIONS OF LIABILITY: THE EXCLUSIVE REMEDY OF THE USER OR BUYER FOR ANY AND ALL LOSSES, INJURlES OR DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER IN CONTRACT, WARRANTY, TORT, NEGLIGENCE, STRICT LIABILITY OR OTHERWISE, SHALL NOT EXCEED THE PURCHASE PRICE PAlO, OR AT BAYER _ROPSCIENCE'S ELECTION, THE REPLACEMENT OF PRODUCT.



# 4 Bayer CropScicnce Bayer CropSclence LP P,O. Box 12014, 2 T.W. Alexander Drive Research Triangle Park, North Carolina 27709 1-866-99BAYER (1-866-992-2937) PREpm brand Ethephon Plant Regulator for Cotton (MASTER) Approved 11/27102. 

# 17

### •



# • UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460



## NOV :' 7

Prasad Raa Avcntis CropScience 2 T.W. AlexanderDrive Research Triangle Park. North Carolina 27709 

### Subject:

Dear Mr. Raa, Prep brand Ethephon Plant Regulator for Cotton EPA Registration No.**264~380** 

### Your label amendment application dated August 12,2002 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES



### The amended labeling referred 

### to above, submittedin connection with registration under the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), as amended is acceptable, 

## provided that you comply with the following conditions.
I. You must make the following changes to the label:

a. At ever), place in the label where 

### it occurs, "PREP" (withollt any additional product name) or "PREP brand Ethephon" must either be changed to a nonspecific tcrm such as "this product" or else changed to "PREP brand Ethephon Plant Regulator for Cotton", the complete name ofthe subjcct product. "PREP" and "PREP brand Ethcphon" are alsopart ofthe name of EPA Reg. No. 264-418.
b. In the "IF TN EYES:" subsection ofthe "FIRST AID" section, in the second statement add "eye" after "then continuc rinsing".

c. In the first sentence in the "PERSONAL PROTECTIVE EQUIPMENT (PPE)" section, add "made ofany waterproofmaterial" after "chcmical resistant gloves".
d. In the first sentencein the second-to-Iast paragraph in the "AGRICULTURAL USE REQUIREMENTS" section, change "chemical resistant gloves such as any waterproofgloves" to "chemical resistant gloves made ofany waterproofmaterial, such as nitrile, butyl, neoprene, or barrier laminate".



# 18

# ..

### • 

## •



# • C. Move the sentence "Do not contaminate water, food. orfeed by storage 

### Or disposal." 

### in the "STORAGE"subsectionofthe "STORAGE AND DISPOSAL" section tojust afterthe "STORAGE AND DISPOSAL" heading, changethe nameofthe "STORAGE" subsection to "PESTICIDE STORAGE", and provide appropriate statements for spills specifically (not solely spills), inthis subsection. 

### f. 

## Inthe fourth scntencc oftile fourth paragraph in the "GENERAL INFORMATION" section, change "Harvest at optimun boll opening

..."to "Harvest at optimum boll opening

...".
g. In the second paragraph oflhe "Pre·treatment With Defoliants Priorto PREP Treatment" subsectionofthe "PRECONDITIONING FORDEFOLIATION"section, change ",

..sectionon how th test for BoU Maturity

...tt

### to "

...section on flOW 

### to test for Boll Maturity

...".
2. Submit one copy ofyour final printed labeling before you release tIle product for shipment.
Ifthese conditions are not complied with, the registration may 

## be subjectto c::mcellation in accordancewith FIFRA section 6(e). Your release for shipment ofthe product bearing the amended labeling constitutes acceptanceofthese conditions.
Ifyou have any questions aboutthis letter, please contact 10hn Bazuin at (703)305·7381.

Sincerely yours,

Cynthia 

### L. GlIes-Parker 

## Product Manager (22) Fungicide Branch Registration Division (7505C)

AttacIunent: Label stamped "ACCEPTED with COMMENTS"



# 19

### r 

# PREpTM brand Ethephon PLANT REGULATOR FOR COTTON FOR COMMERCIALUSE OR AGRICULTURAL USE ONLY. NOT FOR RESIDENTIAL USE. ACTIVE INGREDIENT:

Ethephon (2-chtoroethyl) phosphonic acid'"

...........................................................'

.....n,...........................................,••••••••••••••••••••

### 39.9% 

### INERT INGREDIENTS:

.......................................................................................................................................................................... 60.1% 

### *This product contains4pounds ethephon pergallon. 

### EPA Reg. No. 264·380 EPA 

## Est. No. 264·PA'()1 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
Si usted no entiende la etiqueta, busque aalguien para que se Ja explique a usted en delalle. (If

### you do notunderstand the label, lind someone to explainitto you in detail.)



## •**.-----------IF~o'rMM~'RDllICA~lAAnnddIT&RA~N~S~P~O~R[TAAT~I~O~N"'~m"e~rgg.e"n~'r.;e"s~O~N~lYfC(.~ITI2Z.4IHHo~u"r'sAA1D".~y"~.8~O~O~.3~344"~7~5777,-----------­** For PRODUCT.ug Information 

### (alf 1-88fJ-.AVENTIS (1-888-283-6847) The use of this product for a variety of plant growth regulation uses is covered by United States and loreign patents including 

## u.s. Patent4,240,8t9. No license is granted to use this product in countries other than the United States or for any use notcontemplated by 

### this label. liabilityfor patent infringement may resultfrom use O! sale ofthis productoutsidethe United States.

IFIN 

### EYES:

IFONSKIN OR CLOTHING:



### IF SWALLOWED:**N~,~**

### TO PHYSICIAN:



### DANGER 

## FIRSTAID

• Hold eyeopen and rinseslowlyand gentlywith waterfor15-20 minutes.
• Remove contactlenses, ifpresent, after thefirst5minutes, then continue rinsing.
• "'I tady;". • Take offcontaminatedclothing.
• Rinse skin immediatelywith plenty ofwaterfor t5·20 minutes.
• call , tadYke.
• Immediatelycall apoison control center or**~octor**

### fortreatment advice.
• Do notinducevomiting unless told to do so by apOison control center ordoctor.
• Have person sipaglassofwaterifable to swallow.

• 00

# n".;"" ,to

# 'n For MEDICAL Emergencies

# call 24 HoursA Day 1-800-334-7Sn. 

## ror I,youwhen,; 1 

## rdoctor,
i II · No 

### II

. Consideration should begiven than this 

## PRECAUTIONARY STATEMENTS
HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

## •••••• 

# . " 

# ... • 

## ••



# ... • 

## •• • COHosive. causesirreversible eye damageand skin irrilalion. Harmlul ifswallowed orabsorbed through skin. Do·notgerin**eye~**

### on sjgn, oron clolhing. 

### ACCEPTED ••: ••: :••••• Harmful orfatal ifswallowed. Avoid contamination01 food. 

### with COiUi\IEN'fS •••• • ••• E • •• dl 

## EPA Letter Dated:.... ••• 

## • • 

## ':; T ••:•••**lj,HI~**

### .. !111'**F~d<,raI** 

### InQectiei1Ie, FUl!l;ic;,ll', 

### "1111 Bwl!'lllk!de Aet, "H**~m,.!dt'<:,** for 110"**I"'~!idde** '''gid'',;,,! l"";"r EPA 1!Pg. No, 

## • 

## •••• • •

•••• 

# ... •• • 

# · ..

## PERSONAL PROTECTIVE EQUIPMENT (PPE) Applicators and other handlers must wear loug-sleeved shift and long pants, chemical resistant gloves (Slldl as Nitrile. Butyl, Neoprene and/or Barrier larninate). shoes plus S{)(ks and protective eyewear, 

### When handlers use closed systems, enclosed cabs, or aircralt in a manner that meets the requirements fisted in the Worker Protection Standard (WPS) for agricultural pesticides 140 CFR 170.240 (d) {4-6)]. the handler prE requirements may be reduced or modified as spedfiedin tileWPS. 

### Discard <lothing and otherabsorbent materials that have been drenched or heavily contaminated with Ihis product's concentrate. Do not reuse them, Follow manufacturer's instructions for cfeaning/maintaining PPE. II no such instructions for washables, nse detergent and hot water. Keep arK! wash PPE separately Irom other laundry. 

### User Safety Recommendations Users should wash hands belore eating, drinking, chewing gnm, using tobacco orusing the toilet. Users should remove clothing immediately il pesticide gets inside. Then wash thoroughly and put on clean clothing. Users should remove PPE immediately after handlinllthis product As soon as possible, wash thoroughly and change into clean clothing. Wash the outside ofgloves before removing. 

## ENVIRONMENTAL HAZARD Avoid spray drift to nearby crops as this product may cause temporary nrodifications in plant growth. 00 nol contaminate water used for irrigation or domestic purposes. 00 not apply diredly to water, or to areas where surface water is present or to intertidal areas helow the mean high water mark. 00 not contaminate _aterwhen disposing ofequipment washwaters. 'IBflo not exceed the rilteof**PR[I>'~** brand fthephon t1ant Regulator for Collon per acre peryear recommended on this label. 

## SPRAY DRIFT Avoid spray drift. Do not apply when weather conditions nraycause drift. 00 not allow this product to drift on to non·target areas. Drift may resull in illegal residues or injnry to adjacent crops and vegetation, in the form of leaf yellowing and defoliation. To avoid spray drift, DO NOT apply aerially when w'uld speedis greaterthan 10 mph or during periods of temperature inversions. Useoflarger droplet sizewill also reduce spraydrift. AVOtDING SPRAY ORtFTAT THE APPLICATION SITE ISTHE RESPONSIBILITY OFTHEAPPUCATOR. The interaction of many**equipment~and·weatheHelated** factors determine the potential lor spray drift. The applicator is responsible for considering all these factors when making decisions. The following drift management requirem(>nts must be followed to avoid off·target movement from aerial applications to agricuftural field crops. These requirements do not apply to forestry applications, public health uses or to applications using dry formulations. t. The distance 01 the ollter most nOllles on the boom must not exceetl3/4the length of thewingspan or rotor. 2, Noules mHst always point backward tlarallel with the air stream and never be pointed dnwnwards more than 45 degrees. Where states have more stringent regulations, they shonld he observed. The applicator should be familiar with anrltake into account the information covered in the Aerial Drift Reduction Advisory below: 

## .ERIALDRIFT REDUCTION ADVISORY [This section isadvisory in natme and does not super5ede tire nrandatory label requirements]. tNFORMATlON ON DROPLET SIZE The most ellective way to reduce drift potential is to apply large droplets. lhe best drih management strategy is to apply the largest droplets that provide sufficientcoverage and control. Applying larger droplets reduces drift potential, but will not prevent drift if applicationsare made improperly. or under unlavorable environmental conditions(See wind, Temperatureand Hurni1tity, and Temperature Inversions). CONTROLLING DROPLET SfZE volume· Use Irish lIowrate nOl.zles to apply tire highest practical sprayV{llume. Noules with higher rated lIows produce larger droplets. Presstlre· 00 not exceed the nozzle manulacturer's recommended pressures. For many nozzle types lower pres.sure produces larger droplets. higher lIowratesare needed, use higher flow rate noules instead of increasing pressure. •• • Number of nozzles· Use the minimum lrUlnber 01 n07.1les that provide uniform coverage. • ••••• 

## • •• 

## • •• 

# .. . When

NOllie Orientation· Orienting nozztes

### so that the spray is released parallel 10the airstream produces larger dropl"s Uran!other orienTations and is the recommended practice. Signilicilutddlectron Irom Irorilontal 

### will reduce droplet size and increasedrift potentiaL...... : ••• :. 

## •• 

## • NOllie Type

- Use a noule type that is designed lor the intenderl application. With most nouletypes, narrower spr3"irfgles proQuc&J"rger droplets. Consider using low·drill uOllles. Solid stream noules oriented straight back produce the largest droplets and the**h~~~l**grift. • ••• : 800M lENGTH :: • 

### ••••• For some use patterns, redUCIng the eflective boom leugth to less thau 3/4 ot the wingspan or rotor length may further reduce 

### 4rT'ffMtllout reducing swath width. ••••


# .. . •• • 

# ... 21APPlICAnON HEIGHT Applications shollld not be made at aheight greaterthan 10feet above the top of the target plants unless agreaterheight is required for aircraft safely. Makingapplicationsat the lowestheight Ihat is safe reducesexposure ofdroplets to evaporation and wind. SWATH ADJUSTMENT When applications are made with a crosswind, tile swath will be displaced downwind. Therefore, on the up and downwind edges of tile field, the applicator should compensate for this displacemenl by adjusting the path of the aircraft upwind. Swath adjustment distance should increase. with increasing rfrift potential (higher wim!. smallerdrops, dC.). WIND Drift potential is lowest between wind speeds of 2 . 10 mph. However, many factors, including droplet size and equipment type determine drift potential al any given speed. Application should be avoided below 2mph due to variable wind dirC{tion and high inversion polentiaL NOTE: local terrain can influence wind patterns. Everyapplicator should be lamiliar with local wind patternsand how they affcrt spraydrilt. TEMPERATURE AND HUMIDITY When making ,1pplications in low relative humidity, set ull equipment to produce I,lrger droplets 10 compensate lor evaporation. Droplet evaporation is most severewhen conditions are both hot anrl rlry. TEMPERATURE INVERSIONS Applications shOUld not occur during a temperature inversion becanse drilt potential is high. Temperature inversions reslrict verlical air mixing, which causes small suspended droplets to remain in a concenlrated doud. TIlis cloud can move in unpredictable directions due to Ihe light variable winds common during inversions. Telnperature inversionsarecharacterized by increasing temperatures with allitnde and are common on nightswith limited cloud coverand lightto no wind. They begin to lorm as the sun sets and olten continue into the morning. Their presence can be indicated by ground log; however, il log is not present, inversions can also be identilied by Ihe movement 01 smoke frorn a ground source or an aircraft smoke generator. Anokethai layersand moves laterally in a concentrated cloud (under low wiud conditions) indicates an inversion, while smoke that moves upward and "IIIIIIlSpidlydissipates indicales good vertical air mixing. SENSITIVE AREAS The pesticide should only be af1plied when the potential lor rlrift to adjacent sellsitive areas (e.g. residential areas, hodies 01 water, known hahitat lor threatened orendangered species, non-target crops) is rninirnal (e.g. when wind is hlowing away from the sensitive areas). 

## DIREUIONS FOR USE Itis a violation ofFederal law to use this product in a mannerInconsistent with its labelin&. Do not apply this product rn away thatwiff contact workers or otherpersons, eitherdirectly orthrough drift. Only protected handlers may be In thearea during application, For any requirements specific to your State orTribe, consult Ute agency responsible for pesticide regula\ions, Read entire label before using this product. 

### USE REQUIREMENTS Use this product only in accordance with its Llbeling and with the Worker Protection Standard. <10 CfR p..lrt t70, This standard contains requirements lor the protection 01 agricultural workers on larms, lorests, nurseries, and greenhouses, anrl handlers 01 agricultural pesticides. It contains

### '~l";'''";,"ld01 training, decontamination, notilication, and emergency .1ssistance. It also contains spC(ilic instructions and exceptions pertaining to statements on this label abollt personal protective equipluent (PPE), notification to workers and restricted-entry interval. The requiremellts in this onlyat1plyto uses 01 this prodllct that are covered by the Worker Protection Standard. not enter or alfow worker entry into treated areas during the restricted-entry interval (REI) 01 <18 hours. The REt is 72 hours in areas where average rainlall is less than 25 inches peryear. PPE required lor early entry to treated areas titat is permitted under the Wnrker Proleclion Standard and that involves contact wilh anything that has been treated such as pialie;, wi! or water is (overalls over 10llg-sfeeved shirt and long Ilants, chenlical resistant gloves such as any waterprool gloves, chemical r{'5istant lootwearplus socks. and protective eyewear. For overhead expoSllfe, dremical·resistant headgearis also reqllired. 1 workers 01 them II entrances to treated areas. 

### STORAGEAND DISPOSAL STORAGE Do not contaminate water, lood. or leerl by storage or disposal 

### PESTICIDE DISPOSAL 

### •••••• 

## • •• • •• • • ••• 

## • • 

## •

•• • • Pesticidewastes are acutelyhazardous, Improper disposal 01**excl'S~** pesticide, spraylnixtllre, orrimate is a violatioijpLf&1I1V31 law:**JI.t1.l~** wastes cannot be disposed 01 by use according to label instructions, contactyour State Pesticide or Environmental Control**A~lCY**Or the ff.!lardous Waste representative at the nearest EPA Regional Oflice for guidance. •• •• :.: 

### CONTAINER DISPOSAL •• :..• ••• 

### •• • Triple rinse(or equivalent) the empty containers. Then olferlorrecyclingorreconditioning. or puncture and**dispos~to'M**a sanital}'"llMfiff. orby incineration or il allowed bystate and local allthoritie$. by burning. II (01\tainer is bllrned, stayout 01 smoke_ •••••• 

## •• • •• • • 

## •• 

# 22

### GENERAL INFORMATION Aloliar spray 01**PREP'~** brilnd Etirephon Plant Regulator lor Colton will accelerate opening 01 mature unopened colton bolls and enhance deloliation which can result in earlier harvest with an increased recoverable yield.**PREP'~** brand Elhcpllon treatment allows increased elliciency Irom aoncc·over harvest Some premature drop 01 smalt immature holls may be associated with treatment Do not apply belore sulfrdent, mature, unopened botts have developed to produce the desired yield 01 colton, A

boll is mature when it is too hard to be dented when squeezed between thumb and lingers, too hard 10 be sliced with a sharp knile, and when the seed coat betomes light brown in color. For best results, thorough and unilorm sprily coverage is required. It is essential that the bolls are contacted by the spray to obtain optimum boll opening. Observe treated lields closely. Harvest at optimun boll opening and detoliation, generally 14 to 21 days alter treatment. Sustained cold weather with average dayand night temperatures01 6S"F orlower alter treatment with**PREP'~** brand Ethepllon will delaythe boll opening response. DO NOT APPLY**PREP'~** BRAND ETHEPHON tF RAIN 15 EXPEGm WtTHtN G HOURS. Rainlali wilhin G hours of application may reduce pro(hlct periornlancc. (ertilied colton seed growers stlould observe bolt and seed Inaturity belore treatment with**PREP'~** brand Etlrephon. Bolls not completely mature might open with treatment01**PREP'~** giving lowerquality seed, tMPORTANT: Do not apply PREP'· brand Ethephon ttlrough any type 01 irrigation**~tem.** SPRAY PREPARATION Add 1/2 to 3/4 01 the reqrrired amoullt 01 water to the spray tank. Start agitation. Add the required ilmount 01**PREP'~** brand Ethephon, and the remilining amollnt 01 water. Preparc only as much spray solution as can be used on the dayol mixing. Do not altow spraysolution to stand overnight. _0 not spilt the concentrateri product orr spray equipment. or any ,1irplane parts. ANY SPILLS SHOULD BE RtNSED tMMEDIATELY WITH PLENlY OF 

### .,ATER. Use01 a nurse tank is highly recommended lor avoiding possihle spills 01 COlrcentrated lorrmrlation on sprayequipment or anyairplane parts. EQUIPMENTClEANING Spraydeposits01**PREP'~** brand Etilephon ,when Ielt on aireral! acrylic plastic typewindshields lor longer than 1hour, may react with this material, larmingan opaque tilm or spots on the surface I'of1ich cannot be removed bywastfmg with wateror anyother deaner. Rinsewindshieldswi1h water immediatelyalter each tankload 01 PREP'" has been applied. Thoroughly rinse the aircraft with clean water alter each day**PREP'~** isapplied. PREP'" brand Ethephon mayalso altC{t certain paints, and ifaccidental deposits on painted objects such as cars, trucks, agricultural equipment, etc. occurs, these objects should be rinsed with water as soon as possible (within 1hour) to prevent perrnanent staining ofthe painted surface. Because ofthe acidic nature olthis product, prolonged eXPQsureto spraydeposit witt damage acrylic plastics, certain paints, and metals, Rinse thoroughly with a detergent and water all exposed aCf)'liL plastic·type materials (e.g

.. aircraft windShields), and painted surfaces within an hour after exposure to spray deposits. At the end 01 each day rinse thoroughly with a detergent and water all the metal parts of the aircraft and the associated spray-equipment exposed to the spraydeposits. BOll OPENtNG

CfiNotTtDNSEXPEGED ·7 DAYSAFTER**PREP'~** TREATMENT QUARTS/ACRE Hot and dryBO'F or higher 1.0 (1.0 Ib ili) Of)' with temperature l.S(1.5lba.i.) 7S'F to BO·F Cool bllt higher than (SF 2.0 {2.0 Ib ai} Rank cotton 2.0 (2.0 Ib a.L) Rates ForBoll Opening ONE GALLON

OF**PREP'~**

TREATS
'1 Acres 2,5 Acres
2Acres 2Acres SPRAYVOLUME GAL/ACRE GROUND AIR 15t050 2toS'"" tSt050 2toS* )St050 2toS* 25t050 5 *NDT[: For Calilornia and Arizona use avolume 01 no less tharr 5gilttons per acre lor ,1eriill**~tlpticatiorrs** 

### ••• Time ofApplication (Boll Opening) •••••• •••••• Apply when there are sulficient mature unopened bolls 10 produce the desired yield, but no later than when

### 6~f**t~e** iollsare optned (see General tntorrnation section on how to test lor bollmaturity). Do rrot tankrnix PREP'· brand Ethephon with adesiccant il therOllon is to he mi",rlle harvested. 

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# 23

# . , PRECONDITIONtNG fOR DEfOLIATION

CONDtTlONS EXPEOEO 5-7 DAYSAFTER TREATMENT Hot and dry 80'F or higher Coof but higher than oS'and afso for rank cotton Rates for Precondftioning For Defoliation**PREP'~** QUARTS/ACRE 05 (05 fb ai) 1.0 (1.0 Ib 

### ail ONE GALLON OF**PREP'~**

TREATS BAcres 4Acres SPRAY VOlUME GAL/ACRF GROUND AtR 1St050 2toS* t5toSO 2105*
*NOTE: For California imd Arizona us.c<l vofume of no Icss than 5gaffons per acrc for aeriaf appfi(ations, Time ofAppfication (Preconditioning} Appfy PREP'W brand Ethephon 4 to 7days prior to appfication of defofiant or tank mixed with the defoliant (see section on Compatibifity). 00 not tank mix PREP'w with desiccants unfess pfant desiccation is required, Pre-treatment With Defofiants PriOr to PREP'" Treatment If the cotton is overfy rank or faying down iu the mirfdfes and good sprilY coverage of the hoffs with**PREP'~** brtHld [thephon is difficult. a prelrealmenl with defofiants wiff be usefuf to improve boff coverage with PREP'w. Use dosage rates of PREP'" recommended for boff opening. Read and observe aft .ppropriatefilbef use directio11s and precautions for the rfefofiant used. Wo not use a defofiant before there are sufficie11t mature ullopened bofts to produce the desired yield (see Generaf tnformation**se(~on** on how til test for Boff Maturity). COMPATIBtllTY PREP'" brand Ethephon is compatible with OEr, FOLEX, DROPP, t-tARVADE, MUl-IYL P,\MTI-IION, GUTHtON AND MAlATHION, and may be appfied in sequence or as a tank mixture (DO NOT TANK MtX WtTH DEFOLIANTS OR lJEStCCANTS tN CAUFORNtAAND ARIZONA). tn some cases sfight reduction i11 boll opening response has betn observed when tank mixes with rfefoliants were used, Good agitation in the spray tank is esse11tiaf and a tank mi:dtlrc shoulrf nol be allowed to Sland without agitatio11 for more than Sto to minutes. Read and observe aU appropriate fabel uS{' dire(lions and precautions lor the defofiantsand inS{'(ticides used. PRECAUTION: NOTE: UNDER CERTAtN CONDITIONS, TANK MIXTURES or PREP'W BRAND ElHEPHON WtTH OESt(CANTS CONTAINING SODIUM CHlORATE COULD RESULT tN THE FORMATfON OF HYPO(lILOROUSACIDS WI-HCl-l ON ItFATING WILL EMITTOXIC CHLORIDE FUMES. DO NOT MIX PREP'w BRAND Ell-lEPI-ION WITH AMMONIUM THIOSULFME. StKH TANK MtXTURES MAY RESULT tN FORMATION OFroXIC FUMES. WHEN TO HARVEST: Do not harvest cotton sooner than 7 days after a treatment with PREP'W hrand Ethephon. Obselve the trl'atl.'d crop il11d harvest when optimum boft .illipeni11g has been reached_ Too early harvest might retfuw the fulf advantage of the treatlnent dnd too fate a hillvest may resuft in reduced quafity and wssoffint which wiff drop from the plan!. USE LIMITATIONS Do not exceed a maximum of2,0 tb, ethcphon active ingredient per acre per year thr011gh combined or repeated uses of any ethephon products. Boll opening: Do not tank mix PREP'w brand Ethephon with adesiccant if the cotton is to be spindfe harvested. Pre·Condition for Defofiation: Do not tank mix PREP'w brand Ethephon with desiccants unfess pfant desiccation is required. Do not uS{' a defofiant before there is sufficient malure U110pened boffs to produce the desired yield (see Generaf Information section on how to test for holf maturity, Do not pfant another (rOilwithin 30 days ilfter treaunen!. USE PRECAUTIONS Avoid spray drift to nearby crops as this product wiff cause morfificatiom in**p~1nt** growth, Pfant inj11ry or reduced yiefdswill resuft... • Mix onfy the amount ofspray you**e~pect** to U5e each day. Do not alfow mixed sohJ1ion to stand ovemight 

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# , IMPORTANT: READ BEFORE USE Read the entire Directions lor Use, Conditions, Disclaimer 01 Warranties aud Limitations of Liability before using this product. 1/ 

### terms are not acceptable, return the unopened productcontainer at oncC. 

### Byusingthis produd. user or buyeraccepts the following Conditions, Disclaimer01 Warranties and Limitations ofLiability, CONDITIONS: Thedirections lor use 01 this proriU(\ are believed to be adequate and sholiid be lollowed carefully. However, it is impossible to eliminate 

### all risks associated with the use 01 this product Crop injury, ineffectiveness or other unintended consequences may result be<auw: 01 such factors as weather ronditions, presence 01 otlier materials. or the manner 01 use or application, all alwhich are bCy<lnd the control ofAventis CropScience. All such risks shall be assumed hy the user or buyt.'(, DISCLAIMER OF WARRANTIES: AVENTIS CROPSCIENCE MAKES NO OTHER WARRANTIES, EXPRESS OR IMPLIED, OF MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE OR OTHERWISE, THAT EXTEND BEYOND THE STATEMENTS MADE ON THtS LABEL No agent ofAventis CropScience is authorized to make any warranties beyond those contained herein or to modify the warranties contained herein. AVENTIS CROPSCIENCE DISCLAIMS ANY LIABILITY WHATSOEVER FOR SPECIAL, INCIDENTALOR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OFTHIS PRODUa. LIMITATIONS OF LIABILITY: THE EXCLUSIVE REMEOYOF THE USER OR BUYER FOR ANYANDALL lOSSES, INJURIES OR DAMAGES RESULTING FROM THE USE OR HANDLING OF

## nus PRODua, WHETUER IN CONTRAa, WARRANTY, TORT, NEGLIGENCE, STRtCT I.IABtI,IlY OR OTHERWISE. SHAll NOT EXCEED THE PURCHASE PRICE PAtD, ORATAVENTtS CROPSCt[NCE'S malON.THE REPlACEMENT OF PRODUCT

.



# ..

•

Aventis CropSciencc USA LP P.O. Box 12014, ZT.W. AlexanderDrive Research Triangle Park, North carolina 27709 PREP is atrademark 01 theAventis Group. PREP'" brand Ethephon Plan! Regulator lor Cotton (pENDING) Slrbnlitted 7/17/02. 

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# · .. 25

# Aventis CropScience

August 12, 2002
Document Processing Desk (AMEND) OfficeofPesticide Programs(7504C) 

## U. S. Environmental Protection Agency Room266A, Crystal Mall 2 

## 1921 

## Jefferson Davis Highway Arlington, VA 22202-4501
Attn: Ms, Cynthia Giles-Parker (pM Team 22)

• Sub: PREP brand Ethephon Plant Regulator for Cotton (EPA Reg. No. 264-380) Revised First Aid Statement 

## DearMs. Giles-Parker:
1 

## am submitting an amended label for PREP brand Ethephon Plant Regulator for Cotton (EPA Reg. No. 264-380)in orderto comply with the directions set forth in the PR Notice 2001-1 (First Aid). 

## This submission contains the following documents:
I. An application for new registration/amendment (Fonn 8570-1) 

### [1 copy) 2. Amended label for PREPbrand Ethephon Plant Regulator for Cotton [5 copies) 

# tit Ifyou 

### should have any questions, please contact me at (919) 549-2302. 

## Sincerely yours,

# 8n-~>-J'h«,_ Prasad Rao

-- Registration Manager E-mail P.r;):".;}.d

..fil**{1@a:-".~n!**

### i.S._'::D

### lJ1]



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## P.fra Ne 2770')· WWlv.us

.**.:rop~clcRct",ave!Uis.com** 

## ••• • ••



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# 26

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# .oEPA Environmental Protoction Agency

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.. hington. OC 204&0 

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# 'PREP~biiind'**"N~J** Plant PM, Cotton 

### 22 5.

## u.n. end Add,.,. ofApplicant {1tIchrd. ZIP Cow{ 6. Expedited Revetw. In**a~ordaOCCt** with AFRA Section 3{clt3} 

### Aventis CropScience**~~l(il.** mV product is similar or identical in composition and labeling 

### P.O. Box 12014. 2T.W. Alexander Drive to: 

### Research Triangle 

### Park, NC 27709 EPA Reg. No. 

# DCh.cJc Hth#1$ • m,wtIdt:Iru$ 

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# El Amendment

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.. ction I and Section 11.1 Revised riff>! Aid $G(;tion ofthelabel to complywith PR Notice2001-1.



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..Cadtl Manager CertHication 

## •••••• Icertitythat the etltllfl'lllnil Ihayti m«I.on thie fonn and all attaetwnanle thereto era tNa, /IOcume and**~**.. .:. 

### Is.
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# .282593 .'

. 

### I-- ,\Vo'Nngton, BC-;04BO 

## Other dor 1 ". 

# 11. eomplnylProduct

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### PM'

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# D Retlnoled

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### 6. Expedited Review. In accordance Section 3(c)(3) IbW), my product Is similar or identical!" 

# , t., .//

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# D Product Name 

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# \ [( "m?" explanation: Uoe 'additional pag'!s)

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### Certification 6. Oato Application I oertifythat tho ot&tomonts Ihavo mado on thiidormand all attachmants**'~.toto** .ro true. oocur,u.and compl"o. Rooelved I acknowledg. thot anyknowingly falao ormisloadinG stall1mont may bo puni,h.-bk byfine orimpritonmont w (Stamped) bothundor apprlCablo lew.

- 3. TItle

_ 4. Typed NtImtI 5.0ato**~** 

### ,8570·t

# ,.",8-04' 

# , Whhf, • EPA FYe Copy (original) Cop,**-----~** ..**~ .~~-~-** 


## • PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS

# ~:~~~~~~~g~~~~~~**Ar:~T~~~~~~;Pu~b"C** reporting burden lor thhl: oOlleotJon of informotfon io "limatod to overoge 0,85 hour p.l

.**,~mo f~~**  I oxlstJng dato "QUrcCJ$. Oltherlng and maintaining tho data needod, ¥od comploting and col/eclion of Information. Send ,.gordlngthe burdon "timet. Of any other •• peet of thiS' (lolloction ofinform.riDn, including r.duclng this burden, to Chi.f, rnformatlon Pottey StoMh, 121361. V.S. En1lfrol'll1\ontaf Protoction Agenoy. 401 M Street. SW, DC 204(10.

## ~~~~~:::;:'Thia form la to be uud lot all

## .pp~o.tion5 for now r4tlisttation, end {Jiltl retogl'ttlltion. atnol'ldmont, rOllubmission. to applic.uons for I I • final printed lebllling, rorogistration, Itc. In ordor to proco:s In application for ill now '.Ol.lt.tionwbmlUed onthi. form, the eocomplnytlul epp{iootion: 1. CortirlCfltion with Resped to Citation of OatalEPA Form 8570-29). III not exempted by40 CFR 152.tf1 (b) (4)); 2. Confidential SUlt_nt of FOlTTIUle {EPA Form 3570-

.. /; 3. Fonnulator'. Exemption Stetement (EPA Form 8570-2.7);

... Rve oopi•• of drah laI»IIng; 5. ThfN GOpIn of any d.t8 eubmittod: 6. Authorilation lener where appllcabl.; 7. Matrioes whera applicable.

### I~'~:~:~~ of Labenna

- LabrUing .hould first be .ubmittad In tho lorm of draft lebote with all eppncatioM for raw regi.tratlon. Suchdreh label. mey be Ii oftyped label text on 8.5 l! 11 Inchpiper for eubmlpjon ore mockup ofthopropoNd lebel. II praplJl.ci for mockup. It.hould be

constructed in a wayAS to fecillt.to .toreoe in an 8.5 x 11 inch file. Mockup lebols signiflcanUy smillafthan 8.5 X' 11 lnehoe should be mounted on 8.5 x 11 inch papar for 'ubmiuion. Submiulon ofData

- Data INbmiued in ,upport of till'**app~eation** mullt bo lubmined in ecoordenca with PR Notice 86-5.

# ~t~~~~~~~~~:~:;p~,.~a." raed the In,truction,lillted below before completing thill opplioetion. Firllt detormilWl the type of**1~,~o~,_Ii_rA.e:J** in Block A. for ere .ubmitting this epplication, For oppUcatlonllllubmined in conneotion with New Rogi.ttation actlol'\S, Sactiol'\t I, III, Ind IV muet be**~y** IIJIPlicent. For eppncations submlttctd In oonneetion with amond.ci roregi:mation actiOnll. reaubmilt!oM,

1=_ti:cetionll. reregistr(ltion., otc
.. Soclions I, 

### n, and IV mu,t ba completed bytho eppUcent. 

### I

.......... A

- Check tha approprl.te action for which you ere submItting this form.

### l~iliJ;Illl!i'll: Thi. 8aclion must be complatod, ell epplicable, for all ragi'tration oction•• 1. CotnpenylPtoduc:t Numbar • Insert your Company Numbar, if ona has baen aullfl'l8d by EPA. Thi. rwmber mayhove bun euignod' ta yO\! as 0 basic ragi.trant•• di.tributor. or all 1m esteblishmant. II your product i. ragistared.lnurt the Producr Numbor. 2. EPA ProductManager· Ifknown, ml in the namo and PM number 01 tm., EPA Product ManQgu. 3. PropOMd Clanlflcetion· Spocify the proposed elnuifloatlon of this product. 4, Product NarM • Entor tho complllta product name of this pesticIda as It wUI appear onthe lobet. Tha name mull bo epaoifio to thia product onlV. Ouplieation of natnOI il rwt permittad among products of tho .amll company. Do not include anybrend name or cOmpanyline dosignations. 5. NOrM and Addr

...nl Applieont·The nama of tho firm orperllon and addrass .hownin your**opp~cotion** is tho penton orfirm to whom tho r.g1ltrntion will bai1f5ued. If you aro actlng in behBlI 01 anothar party, you mu.t $ubmlt authorizalion Irom thllt party to act for damin rag1.lta!lon rrumare. An appUcant not toeiding in tho United Stoltl, mu.t hove an authorized llQont rO$iding in the Unitad State. to let for them In ell rlgiatrotion matturl. Tho nnmu.nd compllta mailing addros.; of $\lch on Dgont mu.t Itltlomplny this application. 6. Expldiled Roview· flFRA netion 3 Ie) 3 lSI pr(>vidas for oxpedited rawow of applle.t!on$ lor ragiJtration, or amendmontJ to existing rogiltrlltiOtili;. thot .ro oimllor or identical to (ltlmr pellticidl ptoduetJ thlt Irl ourrently ragist.red with tM EPA. In order for your app!lcltian to btl Dligiblo for a:quMlited raviaw, you mustprome UI with tho EPA Regl1l11rntion Numb,r and product nllmO of tho product you baliova Is iJ1miler to or Idlnticol your product, The product /T1I.Hrt bo llimilar or idontical in both formulation and lablllod us••.

## !~~~~~I~ 

# II-

Thielo.ctlon mu" be oomplelad for alt app1itllltiona IIUt>mltI'Id 10 omand tha regillUation only of. eurrantlyragi.tarod product

for. r8$ubmiasion In reaponlla to an Agtumy I'tt,r. for notificlltinnll to tho Agancy, for the lIubmiulon offinal printed labetllnll. for and for Iny othlr action that pllrtllins to a spllCific EPA-raWstllrad producl. Thi

... etlonf.!l!U 

### 12

### 1m Uled far a now appIioation for

t. Subjec:t of. eubmt.cion· Chock tho applicllble block end provide the Agency letter dOlO If IIPpropriot8. Provide a brial a)(planatlon of me purpOIIISI for tim eubmi.$ion. such

# II' ""the ilddition of a $lte. past or crop Izpacily)-; "IImIInd the Conlidel'ltiol Stotement 01 Formula by

..."; ""rerogi,ltetion wbmiHlon""; -OIIl"H1rallllbel ravisian of usc diraotiornl.- Att&ch 0 eaperate paoa II odditiofWillpaee is needed. 

### 1111 and ContainerInlormlillon)

- This SeClion must

### bo completed for all IIPplicQtions: submitted in connaetion With new**~**.. ble amendments. 1. Type ofP

....oglng • Chock tho flppropriullI block if your product will be pllCkagad in thaindicaled pockaging typeii'. Indlcatl the allO of the individual Pflt:!<:IIIli: find number per ratllil**contuin~r.** 2. Type ofR.taII Container· Indi¢eto typD ot contilin.r in which prGd\lct win be merkOtod. 3. Locatlon of NetCentantt- IndIcate tho loclltlon of tM net contentt Information lor your product. 4. Sin{.l of ReUlil ContliMr· Specily tho net contonts of l1li retail contelrl(lrs lor yout product. S. Locetion of

# u.:. Dittctlont· Indicate the 10cQtion of tho use diroctions lor your product. 6. MInner In which lebtl. efftud to product

- Indicated the method product lebel is attachod to retail conteiner.

### ~:,~~I!!**IV~** ICont.ct Pointl

- Thie Section muli't

# be oomplutlld for all application. tor Rogistration ections. i.a

.. new producto regisuotion. ""me-tot,."" ror.gi.ltlltlon. alC. t·S. SeU

.. xplunatory. 6. EPA U.a Only.

# , 

# PREpTM brand Ethephon PLANT REGULATOR FOR COTTON FOR COMMERCIAL USE OR AGRICULTURALUSE ONLY. NOT FOR RESIDENTIAL USE. 

### AUIVE INGREDIENT:

Ethephon (2-chloroelhylj phosphonic acid'"

.."

..........,.................."

.." 

### INERT INGREDIENTS:

...................................................,...................... 

### wTllis product contains 4pountls ellieplion per gallon. .....................39.9%

..................... 60.1% 

### EPA Reg. No. 264-380 EPA Est. No. 264-PA-Ol 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
Si**llSl!~(1** no enliende la etirtlleta, husqllc a alguien para que sc la expllqllc a usted en detalle. 

# • (II YOII do not**llllder~lamJ** the label, lind someone to explain it to yOIl in detail.) 

# "et For MEDICAL And TRANSPORTATION Emergencies ONLY call 24 Hours A Day '-800-334-7577

# ~>"f"::?v~ For PRODua USE Information (aIl1-888·AVENTIS (HJ88·283·6847) "I -,;:,
. If

- ;:;OO-33.'i-'17'f5 rhe use 01 tllb producl lor a variely of plant growlh regulalion uses**i~** covered by Uniled**Slate~** and lorcign patenh illduding u.s. Patenl 4,240,819. No Ijc('nse is granl('d 10 use this product in collnlries olherthan Ihe Uuile<l Slates or lor anylISe nol conlemplaleti by this labeL liabilily lor patenl iniringeillent Illay resull Irom use or !t<lle01 this product outside the United**Slate~.**



### IF IN£YES:**IFON~f(IN** 

### OR



## TO Ii 

## PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

### •••••• 

## • •• ••• • 

## ••

••• • •• •**(orro~ve_** (allses irreversible eye damage and skin irnlallon. Ilannhil il**~williowed** or absorherl Ihrollgh skin. 

### Do '101 get'll eyes..on**~ill.** or on dolhing. ilarmlul or falal if**~walloweri.** "voirl wolalillnalion 01 food_ 

### •••••• 

## • • • •

•• ••••• • 

## • • • 

### ••••• •

### ••••• 

### •

### •••• 

## • ••

•• •

• •

### ••• 

## • •



### •••• 

## •• • •• • 

## • ••

# ~~......le 

# "f CV'.-°f

# ""~I' M> 0 

# f'**~e-v-:.,J** PERSONAL PROTECTIVE EQUIPMENT (PPEj

.. 

# i

.. . Applicators and other handlers mllsl wear IOllg·sleeverl shirt ilnd long pants, ChemlGll reSIS\iml gloves (weh as NlinJe, Bulyl, Neoprene and/or Barner lilmillJte). slloes plus socks and prolecliveeyewear. when handlers lise dosed systems, enclosed cabs. or ahuaft in il manner thai meets llie requircmcnls lisled in the Worker Proleclion Slinufani (WflS) Jor agriwUural**peslicfde~]40** erR 170240(d) (+6}j, Ihe hanrJler prE reql]lfemenls may he reduced or modilied as sfle{ified in til('WI'S DisGHd <lathing and olher absorbent materials that have been drenched or hNVily (Qlliaminaled with Ihis prorlu(t's wn(cnlrale. Do nol (,lISe them. follow manufadllrer's inslrnClions lor deaning/mainlilining prE. If no sudl instructions lor wasllahles, uS(> detergent ami hot water. Keep and wash PPE**~eparatcly** Irom other laUllury, 

### User Safety Recommendations Users should wash hands belore ealius. rtrinklllg. dlCwlllg gum, using tob.1«O or using Ihe toilel. Users should removedolhingimmerlialely if pesticiLie getsinside. Iheu wil,>h thoroughly and plrl on c]e,ln dothing. USers should remove PPE imrnerliateiy after handling**thj~** produ(\. /\'0 soon 

### as po,>slble, w,1'>h Ihoronghly anrl chanb'<' inlo dean dolhing. Wash the outside 01 gloves belore rentovin)!. 

### ENVIRONMENTAL HAZARD Avoid '>pray drill to nearby crops as Ihis pruducl mJy calise temporary modificalion,> in plant growlii. Do not conlaminate water nsed for irrigatioll or domestic purposes. Do IIOt apply directly 10 watel, or to areas where surface waler I'> present or to illtertidal areas helmv tile mean fliglllv,lter mmk. Do not (Qnlaminate water when dispo,>ing 01 equipmenllVashwaters.

## ~ not exceerl tile rate 01

## PI![P'~ br,uld 1:IIIepiiOil Plalll Regulator lor (olton per 

### aae peryear recommended on Illislabel. 

### SPRAY DRIFT Avoid spray drill. Do nol apply when we,lther condilion,> may cause drill. Do nol (lilow Ihi'> produ([ to rlrift ou to non-target areas. Drilt may re,>ull in illegal residUes or iufnry to adiacenl (lOfIS (lnd "egelation, in Ihe form 01 leaf yellowing and deloliatioll. To ilvoid spray drill, DO NOT apply aerially wilen wiud speed is greater than to lIlph or dllring periods of temperature inwrsion'>. U'>e 01 larger droplet sizewill also reduce '>praydrill. AVOIDING SI'RAY DRIFr 1\TTHE I\t'I'LlCo\TiON SITE IS TIlE RfSPONSlBlUlYOF THE I\I'PLICATOR. 1he interaclion 01 mallY equipment'Jnd·weatJler·reJaled lactors deternline the potential lor '>pray drill. 1he .1IlpliGl\or is**re~pnnsilrle** lor comirJering illlthe,>e factors when making**deci,>iOlI~.** 1he foliolVing drill managernenl reqnirements mllst be followed to avoid olHargel movement lrom aerial applicalions to agricultnral lield (fOP'>. These rellirirementsdo nol apply 10 100e'>try applicatiollS, pnblic hC,lltfl Irsc'> or 10 application'> using drylormulalions. 1. The distance 01 the outer most nOllles ou theboom Illllstnot exceed 3/01 the lengtll 01 thcwingspan or rotor. 2. N07.zles must always poinl hackwarrf parallel wilh the airstream and never be pointed dowmvard,> Inore Ihilll 45 degrees. Where stales h,lVe more Slringellt regulalions. Illcy shonld be ob'>er\'ed. 1he applicalor should be 1.1lnili,lrwith anff 1,lkc hllo acconnt Ihe inlormalion covered in Ihe Aerial Drill RerhlcliOiI ArJvisorybelow:**~RIAL** 

### DRIFT REDUCTION ADVISORY ,.Ii'>seclion is advi,>ory in nature and doe,> 1101

### ~uperseffe Ihe fll.1l1dalory lahel rertllirementsj.

INFORMATION ON DROPLET SIZE rile IllOSt efJective way to r('allce drill polenti,ll is 10 apply large droplel,>, The be'>t drift rnanagelllelit strategy is to ilpply the large'>t rfrOlllet,> tflat I)rovide snlficient coverage ilnd conlro!. Applying larger droplet,> reduces drill potenliaJ. but will not prevent drill il .1PlrlicatiollS are llIade impropeay. 01 nnder nnl.1vorahleellvironmental cnmlitiom(SeeWlnrJ. remperiltnre and Iinmirfity. alllfTemperiltnre Inver'>ions). CONTROlliNG OROPLET SIZE Vohlflle· U'>ehigh flow rate n011les to ilpplj' the highest IlrJctic<l1 spr,ly vollnne. Nouleswith higher raled ilolVs produce larger droplets. I'ressure· Do nol exceed the noule lIIanllfaclurer's recommended**pre~'>lIIe,>.** rOr m,HIY nozzle**type~** lower prC'>snre produce,> larger droplels. higher 1I0w rates are needed. (l'>Chigfl('r 1I0\\' rail.' n071les in'>tead 01 increa,>ing pre,>,>\He. 

# .,

# . Number 01 noules· Use the Inininlum nUllifier 01 nOllles IIlat provirle nniform coverage. • ••••• • ••••• Wilen

Nozzle Orientation

- Orienting nOZZles ill that the '>pray is releaser! parallel to Ihe airstream prodnces larger droplt1s th:ntther**orien~tions** and i'> the recommended practice. Significant deJJeClioll lrom horilonlal wilJ rednce droplet si7e and increase rJrift potential. •• 

### •••••• •••••• Nowe Type

- Use a nonle type Ihal is designed lor Ihe inlcnded application. Wilh mosl noule Iype\ narrower spr<w an@lespro·ducelarger dropJels (omiderI)sinll lOW-drift Iiouies. Solid ,tream nOlllesoriented strai}lhl ]),ltkproduce Ihe largestlfropletsand tile lowc,>t"d'rill. ..:.: 

### ••••• ••• BOOM LENGTH • • 

## •• • For ,>olne (lse Ilallerns. reriliting tile elfettlve boom length to b,> than 3/4 01 the wing,>pan or rolor lellgtll Illay**furil~er**·reduce**Ilrifl.,,~ho(ll** reducing swath wifUh •••••• 

## •• • 

## •• 

## • • 

## •• 

# 31APPLICATION HEfGHT APfificafions should not be made a! aheight greater thilll -10 feel above tile lop of thelarget fdillltS uiliess il greater freiglr! is rertllirerJ for aircr;lft S<lfely. Maldllgapplications al the lowest heightlllJI is safe rcrfll(cs expoSirre ofdrotdets 10 evaporation anrl !Vim!. SWATH ADJUSTMENT When appficatiol($ are marlc with a (fOSSWilld, the swath will be displaced downwind. "fIrcrelore, 011 tire lip .lInl rfolVnrvinrf edges of the field, Ihe applicator should COlflpensate for tlris**rli~pla(ellient** br adiU'>Iillg the path of lire aircraft 1I\lwilld. Swath ilffjusllllcnt distance should illcreasc. with illucasing rlrift potential (higherwim!. 'Smallcr ilrop\ etc.). WIND Drift potential is lowest between !Vim! sllcerfs of 2 . 10 Infrfr. However, many lilctors, incfllrfing droplet size and equipment type determille drift potel\tial at any given speed, Apflfkation shol1fd be avoirled bdow 2mph doe to variahfe wind direction and high inversioll potential. NOTE: local terrain can inffuence wind pafterns. Every af1plicator sholild he lililliliilr with lo(af lVinrJ palterns (lild how tlley affect sfJfay rfrifL TEMPERATURE AND HUMfDfTY When making applications ill low relative hllillidity, sct Ufl equipilielit to**prorlu~e** filfger dropfets to collipensate lor evaporatioll. Droplet evaporatioll is Inost severe I'Ihen conditionsare hoth hot amI riry. TEMPERATURE fNVERSfONS Applications sholild I\Ot oc(Ur during atemperilture inversiOIl because drift potential is high. T elllfJeratlire illversiolls restrict verticafair mixing. which callscs slOan suspeorled droplets to relliaill ill iI con(enilated cfoud. This cfoud Cilll move in IInpredictahfe directions due to tile light vilfiable willds Wlltmon during inversions. Telilpewture iliversioliSare (haracterized by**ill(fea~ing** tenIperiltures withaftitudeand are commoll on nights with limited dOlld cover and light to no wind, They begin to lorm as the sun sets alld oftell colltillue into the mOffling. Their preserlce Ciln be indicated by ground log; however, il fog is not present, invNsions (an illso be idelltifierl by the Iliovenient of smoke lronl a glound S(lnrce or an ailCfaft smoke gellefatol

. ....ir0lieIf\at layers and Inoves lateraffy ill a concentraterl !loud (undel fow wind cOllditions) indicatesan inversion, while sUloke that nloves uf1ward and 'llJPidlyrfissip,ltes indicates good verti('11 air lIlixing.

SENSfTfVE AREAS lhe pesticide should only be applierl when the potential lor drift to adjacent sensitive areas (e.g. residelltial areas, bodies 01 water, knol'm habitilt lor threatened or endangered sper.ies, non·target (rops) is It\inimill (e.g. wilen winrl is blowingaway Irom the sellsitive areas). 

## DlREalONS FOR USE tt is it violation ofFederaf law to use this productin a mannerinconsistentwith its labeling. Do not apply this productin a way tha1 wifl contact workers or otherpersons, eitherdirectly orthrough drift_ Only protectedhandlers may be in thearea during application. For any requirements specifiC to your State orTribe, consuft the agency responsible for pesticide regulations. Read entire label before using thIs product, 

### AGRICULTURAL USE REQUIREMENTS Use this prodllct only in ilccordallce with its laheling alld Ivifh the Worker Protectiun Standard, 40 CFR part 170. TIIis st.lIIilard colltains rcrillireifielits lor the protection of agriculturaf I\'orkers 011 farlllS, forests, lIurseries. and grecnhouses, afllf handlers of agrimifllr<ll pesticides. It rOlltains requiremellts for traillillg, rlecontalllin,ltion, lIotiliCiltion, ,1orl emergency 3ssistall(e. It alsO colltaills**~pecific** instructions and exceptions pertaillin)lto the statelllcnts on this label about personill protective ('flilipillellt (PPE), notificatloll to \VOlkers and restricted·elltry interval. Tile reqilirelllcnts in this only apply to uses of this flfodllctthat MC covered by theWOIker Protectioll Standilfd. not enter or allow wOlker entry mto treillrr! ilreas dllring the rCsiricterf'(,lItry IIIterval (REI) 01 48 hOllrs. rhe REf is 72 homs ill areas rohere**aver~ge** i II is less than 2S Illdies per year. prE required lor early entry to treaterf**Jfea~** thilt IS penllilted under the WOlker Protectioll Stallifanf and tllat involves been treater! such as tllants, wil or water**i~** coveraffs over long·sfccved shirt alld long pants, (hemiGiI resistallt 

# ,I""C\D£ dlcmicafresistant footweilr flfliS socks, allr! protective eyelvear. ror overhead expoSllr(', dlemicaf-resistallt headgear i 

### ",""",h"'" I f ,I I I 

# " -;

### I~',,-,,,",-,,., 

### t,-, .".; t- f) Do not contamillate Ivater, lood, or Iced Ily stor;lge or disposal. ,.......-/ 

### •••••• •

## •• PESTICIDE DISPOSAL 

### • 

## •• • 

## •• • Pesticirle wastes are acutefy flillarrlOils. ImplOpcr Ilisposal of excess pesticide, sprJy filixtille, or rillsate is a violafiol\01 lederal lill'I.• tI tll8':>(,wastes Cilnnotbe disposed 01 by useaccordill)l fo filbel instructions, COlltact yOllr Stilte Pesticide or**EII~ironlnelital Control1.g~(Y:r**  tile I4UrMusWaste repres(,lltiltive at 1111: nearest EPA Regional Office for gllidance. • ••• • ••• 

## • •• CONTAINER DISPOSAL Triple rillse (or I



# ,; the empty**rontainer~** state,lnd loral 

# , if I 

# ,, ••••• 

## • • 

## •• • •• 

## • amI**rlispo~tII**trPa**sanitaryJil~1Iill,** or by 

### • 

## •

### ,----- .-

...- ..•

### ----. 

## ------_._- ----------------

GENERAL INFORMATION ,\ foli,lr spray of PREP'" branrl Ethepliofl Plant Regulator for Colton will iI(CClerille opening of mature unopened cotton bolls ilOd enliance defoliation whidl 

### an restill in earlier harvest with an increasel! recoverable yield.**rREr'~** IU;lIIrl Ethephon treatmellt allows increased eliiciel1cy from a once-over harvest. Soille premahlre drop of**~lnall.** imma\mc bolls Iliay he associalL-d with treatmellt. Do nol apply before sufficient, maim!', IInopened bolls have devefoped to prodllc€'thedesired yield ofcottOIl. Aboll is mature wIlen it is 100 hard to be dented when squeezed betweell thumh and lingers, 100 hard to be sliced witll iI sharp knife, and when the seed coat becomes light brown in color. :.tV\. For best results, thorough and 

### lmiform spray coverage is

### ren~d. II is essential that the bolls are conlacted by tile spray to obtain optimum boll opening. Observe trealed lields closely. Harvest at optimu6lboll ollening anrl defoliation, generally 14 to 21 days alter treatment.

### SlIsl~ined cold weather willi average rlayand night tenlpera!lJfes01 

### 65°F or loneraltertreatment with**PREP'~** hrand Etl1ephon will delay the 

### boll opening response. 

### 00 NOT APPLY**PREP'~** BRAND fTllEPIiON IF RAtN IS EXPEGW WITHtN 

### 6 \lOURS. Railiiall withill 6 hours 01 application may reduce prodllct perlormance. (ertilied colton seed growers should observe boll ami seed mahlrity before treatmellt with**PREP'~** brand Etflephon. Bolls not conlpletely mature migllt open with tre!ltment 01**PREP'~** givillg lower qllality seed. tMPORTANT: Do 110t apply**PREP'~** branrl fthepllon through allY type of irr'lg<ltion syslem. SPRAY PREPARATION Add 1/2 to 3/4 01 the required amount 01 water to the sprilY tank Start agit!ltioll. Add the reqllired amollnt 01**PRfP'~** brand Ethephon. alld the remaining anlount 01 water. Prepare only**a~** milch spray solution as can be used on thedayol mixing. 00 not aliowspray solution to stand ovemight. Do not spill the concentrilted product nn spray equipmellt. or i1ny airplilne parts. ANY SPillS SIIOUI.O liE RINSW IMMWIATElY WITH PLENTY OF 

### .TER. 

# "'!rse 01 a nllrse taflk is bighly reconllnended lor,woiding possible s\1ills 01 (oncentrate(llormulatiOIl on spray eqllipment orany airpl;me parts. EQUIPMENT ClEANING SpfilYdeposits of**PREP'~** brand fthephon ,wIlen lell on i1irerall acrylic plastic trpewindsllields lor 10flger than t Iiour, may react with IIlis material, lorming all opaque lilm orspots on the surfacewhich cannot be removed by**wa~hing** with wateroranyother cle!lner. Rinsewindshieldswith water immediatelyafter eilch tankload 01 PREP'" has been applied. Thoroughly rinse theaircraft with clean water alter each dily**PREP'~** is applied.**PR[I"~** brand Etheplloll may also allect certain pailItS, and II actitlelltal deposits 011 painter! ob[ects such as cars. trucks, agricultural equipmellt. etc. O((llrs, Ih(3e obiects should be rinserl witll willer as soon as pOSSible(witilin 1Iiour) to prevent permanent staining 01 the paillted sur/aCl', Seallse01 tile acidic nilture 01 this product, prolonged expO$llre to spraydeposit will damage acrylic plastics,**cert~in** paints. anrllnetals, Rinse thoroughly wilh a detergent and water all exposed acrylic plastic-type materials (e.g., alreralt windshields), and paillted sllrlilccs within i1n lIour alter exposure 10 spray deposits. AI the end 01 each dilv, rinse Illoroughly with a detergellt arid water all the metal parts 01 the aircralt and tile associated sprilyequipment exposed to the spray deposits.
BOllOPENING Rates For 8011 Opening**~NDtTtDNS** EXPECTED ONE GALLON SI'RI\YVOI.UME DAYSAnER PREP'" OF**PREP'~** GAl./ACRr. RfATMENT QUARTSjA(J{E TREATS GROtJND AIR Itot <lntl rtry 80'F or Iligher 1.0 (LO Ib a,i.) <11\cles 15 to SO 2 to 5'" OrylYitll temlleriltllre t.5 (1.51b a.i.) 2.5Aeres 15 to 50 2to 5'" 7S"F to OO"F Cool but higher tlliln 

## 6s"r 2.0 (2.0 IIJ a.i.) 2Acres f5 to SO 2to 5* Rank cotton 2.0 (2.0 Ib iLl.) :2 i\Ul'S 25 to 50 5 "'NOTE: Fnr Calilorllia aml,\riwna lise avnlume 01 no less tlwi 5gallons per am-:- loraeri;!1 atltlliciltiol1s Time ofApplication (Boil Opening) 

# ., 

# . • 

## •• •••••• 

### ••• Apply wilen tllere are slillitient malure IInopened holls to prodllce the desired ¥ield, bllt 110 later thiln when 60\'(01 tCe t'olls are oplOned (see GClleral Information section on IlOw to test lorbollmatllrity). Do not tank mix**PREP'~** bralld Ethephon witll a deslccallt il tile colldh is to tie spiJldle**h~lvcsted.** 

### •••••• •••••• 

## •• • 

## • •



# .. ••••• 

## • • 

# • • ••••• • ••• 

## • ••



# .. .

• •••• 

## • •

•••• 

# .. . . , 

# . · 

# ..33PRECONDITIONtNG FOR DEFOLIATION

CONDITIONS fXPFOEO 5·7DAYS AFTER TREATMENT Ilot and dry 80"f. or higher Cool bllt higher than 65"lInd also for rank (otton Rlltes For Preconditioning For Deloliation**I'R[I"~** QUARTS/ACRE 0.5(0.5Iba.i.) \.0 (1.0 Ib ai) ON[ GALLON or**PREP'~**

!REATS
8Acres .) ACles SPHAY VOLUMF (lAt JACRE GROIJNO ,\lR t5t050 2t05* t5t050 2t05***~NOIE:** For Calilornia and Arizona nse<l volume 01 no les, liMn 5gilliom per acre lor aerial Jflplicatiorls. Time ofApplication (Preconditioning) Apply**PREP'~** brand Ethephon.) 10 7days prior to irpplication 01 defoliarrt or tank**mi~ed** with the rlefoliarrt (see senion on CompatibiIiIY). Do not tank mix PREP'" with desiccants urrless pl<lrrl**de~iccation** is reqrrired_
Pre·treatment With Defoliants Prror to PREP'" Treatment II the cott011 is overly rank or**la~'ing** down in the mirldles arrd good slrray ccwerage 01 the bolls with PREP'· hrarrd Elhephon i, dilfiwlt, 

### apretrealnwrrt with defoliants will be uselul to improve boll coverage with I'RfP'". U>e do>age rates 01**PREI"~** recommended lor boll opening. Read and observe i111 appropriate labt:'! use diredions and precllrrtiorrs for the deloli;mt rrsed, 

# a.. not use a deloliant before there are slIlIicient 111atrrre unopened bolls to prodrrce the ricsired yield (see Generallrrlorrnation section on how(lIihesl

### ....aro~ 0011 Maturity), ( COMPATIBILITY 

### Yo**PRtl"~** brilnd Ethephon is comp;!tible with Off, FOLEX, OROPP, tlARVADE, METHYl PAHAmION, GUfHION AND MAl.AlttlON, and way be applied ill set]rlence or as a tank m'rxtme (DO NOT TANK MtX WITIIQ[fOLlAN"lS OR DESICo.N1S IN G\UrDRNt,\ AND ARIZON,\), In some cases slighl redllCtion in boll operring rewonse hils beerr observed when tank**rni~es** with defoliantswere userl. Good ilgitiltion in the spray tilnk is-esserrtial and a lank mixtrrre sh01lld not he allowed to staml withorrt agitiltion lor more than S1010 rninntes, Rl:'ilfl ami observe ilil appropriilte label use direlliorrs ,rr1f1 prec;rutions lor lire rlcloliants ilnd inse<ticides used. PRECAUTION: NOTE: UNDER CERTAIN CONDITIONS, TANK MIXTURES OF**PREI"~** BRANO ETIIEPIIDN WITII DESICCANTS CONTAINING SODIUM CIILORATE COULD RESULT tN TIlE fORMr\TiON Of HYPOCIHOROUSACIDSWttlCH ON tlFATING WILt [MIT TOXIC CitLORIOF fUMES. 00NOT MIX PREP'" BRAND lTI1EPliON WITH**"'.l~IONtUI.t** TI-lIOSUtfAl[ SUCH 1,\NK MIXltJRf:S MAY RI:SULTIN fORMATION anoxIcFUMf5. WHEN TO HARVEST: Do not halVest cotton sooner than 7**d~y5** after " treatment with**PRr:P'~** braml f:theplron Observe the treated crop ami harvest when oplimunr boll opening has been reached. Too earlyhalVesl might reduce tire lull advarrta\W 01 the trealment and too late<l harve<,! rnay reslrlt in reduced qual'rty artd ass01 lint whklr will drop Irom the plan\.

## ~SE LIMITATIONS Do not exceerl iI maxinrrlm 01 2.0 111, ellreplrop aClive ingrediel1\ per aueper**~'eilr** lhrouglr conrbined or retleilled r)scs 01 anydllephorr products, 13011 Opelling: 00 110t tank nrix**PREP'~** brand EthephoillVith

### adeSlccallt 11 the cottorr is In he spi11dle Ir<lr\'esterl. Pre,Conditioll lor Dclolialion: Do not t,1llk mix**PREI"~** brand Ethephon with Jesic(ilnts llnless plant desiccation is req1lired. Do 1I0t 1fSC a defoliant helarc there is sl1l1iaent nlatrrre unopened bnlls tn produce tire desired yield (seC' General t(\lonn,l1ion settion un Irow to test lor holl rrriltrrrity. Do nOl**pl~nt** another cropwitbin 30 days alter trealrnerrt, USE PRECAUTIONS Avoid spray drill to nearby crops as this product will (ause rnouilic,lIions ill plallt growth, Plant injury orr(!du(ed yieldswrll resrrl!... • Mix orrly tire i>mount 01 sway YUII {'xpect tn rrsee.1fh rlay. Do 110t allow rrrixed solution to starrri owrnigh!. • ••••• • ••••• 

## • •• • •• • 

## • • 

### •••••• 

## • • • •

•• ••••• 

## • • 

# • • ••••• 

## • • •••••• 

## •• ••• 

## • ••

•• • • •••• 

## • •

•

### ••• 

# . , 

# . 

# ., 

# . • ••

# 34

### •



# •



# • rr"Y" 

### "LtMLl cD Wi'\f{Ri\ NT'-i 

## IMPORTANT: READ 

## BEFOREUSE

# ~ AND Dr.$ CL-fl"Ltl-H' R. 'I 

### Warrdn!ie$ and timilation$ 01 liability before using**Jhj~** product 

### II lerm$ are 

### IWarranties and limitatlon$ofLlabillly\"

Avenlis.CropScienceUSA lP -.

## cJ,,\'-Cl-':J~ 

# r 1-0 J/v'\ ,,, 

### R 

## k--d

.., e - t>e;('vL:>vl. c 

### A

## ~ G\.>\.-\.."fC-LV"I./ II P.o. Box 1201'1, 2T.W. Alexander Drive ••• 

### Research Triangle Park, North Carolina 27709 , •••••• ••••••

## PRFt'isillrilrienlilrkoftheAv('nti~Group,-**J\A'~n1~~** 

## rro...", 

# "R H Ot-J

## E.- 

# -rOlft l-:E

# tJ DIJ**I'R[r'~** hland Hhephon l'lanl t1egulalor lor Cotton (PENDINC) Subm'llIl'{17/17J02-**d\.-~,-~**

# e<l. •••••• 

## • 

# • • 

## •



# .. ••••• 

## • • • • ••••• 

## • • •••••• 

## •• ••• 

## • 

# ••



# .. .

• •••• 

## • •

•••• 

# .. . . , 

# . · ..35

# •



# • UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON. D.C. 20460
08/21/2002



### PRASAD RAO AVENTIS CROPSCIENCE USA LP P.O. BOX 12014 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES 

### 2 T.W. ALEXANDER DRIVE RESEARCH TRIANGLE PARK NC 27709



### PRODUCT NAME, PREP BRAND ETHEPHON PLANT REGULATOR FOR COTTON COMPANY NAME, AVENTIS CROPSCIENCE USA LP OPP IDENTIFICATION NUMBER, 282593 

### EPA REGISTRATION NUMBER, 264-380 

### EPA RECEIPT DATE, 08/15/2002 

### SUBJECT, RECEIPT OF AMENDMENT DEAR REGISTRANT, The Office of Pesticide Programs for an amendment and 

### it has passed completeness. 

### has received your application an administrative screen for During the initial screen we determined that the application 

## qualifies for fast track review. The package will now be forwarded to the Product Manager for review to determine its acceptability. If you have any questions, please contact C. GileS-Parker, Product Manager 22, at (703)-305-7740 .



### Sincerely,

Front End Processing Staff 

### Information Services Branch Program Management and Support Division

IntemctAddress(URl) • http://wWw.cpa.gov**R~cycllldIR"",yclablll.** Prlntod with**VlIg~tablo** 

### au SaNd Ink.on Recycled P"POI (Minimum 50'1. Postconsumer content) 

# 36FRONT ENU... PROCESSlNG APPLICATION INFORMATION CImCT<: ClS'r



### PM 

# cA ;2

# EPACOMPANTNUMBERd~ Y 

# -;3S13

EPAREGIBTRATION

# NUMBERSTATUS 

### (FORAMENDMENTS)

. '. , .. . c------'-**A~** 

### CANCEI:r:ED**NOT.INREFS:_~** 

### , "ME-TOO" errED PRODUcrSTATUS 

### Aqr:rtr&,
__ 

### CANCELLED,

__ NOTmREFS,

__ _ 

# • DATE 

# %'c7!-z:;,;'L



# •

37

# • APPLICATION FOR AMENDMENT

WITH DATA 

## lNlT. DATE FEU
__ SIG(DATA)
____ _ PM NO DATA 

## lNlT. FEU/:W'

" 

### PM 

# /7'.2 DATE

OPP#

### ~2,V,,;;'7;-



# 38

## PESTICIDE REGISTRATION ACTION TRACKING SYSTEM (PRATS) CODING FORM BAR CODE, 

## S6:217--:z:t ID NUMBER, 

# :2.6'4-380 ACTION CODE, 

## 30D

, 

### PM: 

### 22 

## REVIEWER, 

# BO!z..LA.l V\ 

## DUE DATE, 

## 1\ / 13. / 02. DATE ON APPLICATION: 

# <t / 

# 12-/0?- EPA RECEIVED DATE, 

# '3 / 

## I,,,>/ D?- PM RECEIVED DATE, 

# j I 

# G I 02- 

## APPLICANT, 

# AVfJ;,S**C-'C±fS~e-v.ce-; PmS~**  13,9.0 

## CHEM CODE (1), 

## 09"1'30( CHEM,

# ~E:'"=':li..JL!,)-"'errk..c:J4!-"'h'---

# _____ _ CHEM CODE (2), 

## CHEM,

_______________ _ DESCRIPTOR, 

# f'BIJ 2-,Q<9[-( 

# (E;'cst**A~d)** 

# IcvbeJ**~3e.,S** 

# • DATA REVIEWS, HED, RCAB

__ _ TB

__ _ RCB,

__ _ DRES

__ _ OREB

__ _ IO

__ _ EEB

__ _ EFGWB,

__ _ ERCB

__ _ BEAD, ACB

__ _ BAB

__ _ EAS,

__ _ 

## RSB, PCRS

__ _ PRS

__ _ PCS,

__ _ PM Team: Carl
__ _ 

### Paul

__ _ Vern,
__ _ 

### Bill



# --- 

# • FINAL ACTION, RESPONSE CODE, RESPONSE DATE,

## _1_1- 75-DAY RESPONSE: 

## YES NO MOS, (1) 

## CITE ALL CRP, YES NO (4 ) 

## NOT APPLICABLE RESTRICTED USE: 

## YES NO (S) 

### SELECTIVE EXCLUSIVE USE: 

## YES NO MANUFACTURING USE, YES NO CONDITIONAL REGISTRATION/UNCONDITIONAL REGISTRATION NOTES,



# 39

# •

• - RHONE-POULENC

RHONE-POULENC AGCOIIPANY
April 8. 1998
United States EnvirOIln1t'Il1<l[ 

### Protection Agency Office ofPesticide Programs Document Processing Dcsk(7505C) 

### 40I M Street SW 

### Washington D.C. 20460-000I**Attentim~:** 

### :"-'1£.**Cyr.tI~;:1****Gile~*Pa!ker** 

### (PM No. 22)

RE: FINISH 

### !t Han'cst Aid for ClltiOn 

### (EPA Reg. No.**~64*564)** 

### Cydanilide Technical (EP:\ Reg. :\0.26..\-565) and 011 Rhone Poulenc Elhcpholl Prmtllc\s (264-257.**~6"\-263.** 

### 264-267.**~6..j.·** 

### 292. 26..1·]76.16

.. k;n. 

### 264-3S0. 26,,\-,,\18.264-5 Iland 26..\-5

..

### 1-3



### This ieuer is to inli.1rm you 1h<l1 dllC 

### to recent organizulionui changl's 

### at Rhllne Pouicllc. Iwill no longer be handling registration issues all 

### cyclanilide. FIl'.'ISI-I 

## il: brand Harvest Aid l'Or Colton. or ethephon prodllcis. 

### \'fr. Warren 

### Davis will aSSlIme n::gul<nory 

### responsibilities for cyclanilide and FINISllk:' He 

### can**b~** 

### reaehl.,.<d at 919·549·2379. Mr. ;-,,'ick 

### Somma will handle all cthcphon regl1latory issues. \:i.:k·s 

### phone number is 919-549-2372. 

### Please addr6s all rUt1lrc correspondel\ce [0 

### \:ick or**W<1rr~n.** YOII 

### should I..."olllinll(, to 

### lise the s<.1Inc 

### lIIailing address 10 

### n:ach Nick 

### or \\·arn.::n.
I

### havc enjoyed \\llrking wilb )011 

### and particularly appn:ciale 

### all oI'your c\)Iltributiol1S 10

### lhe Flt\ISH**~ regi~1ra\illl1**  

### thi::.**p~ISI** 

### year. I

### call ho

.. ' n.:aciwd**~!1** 

### 919-549-26S"7 i

# ryml I!;l\ ('**an~** 

### qJll.'slions.

Sino:reiv

.

# .AUjJ~ Gail S. Po\\ell, Ph.D. Senior Registralion**~lanager**

PO BO;( 12{)lJ. 2 'U, A'_f:;(I<liG>.:R Dfl:VE RESEAR(;(-l TRIAhCLl PARi< r1C**2;70G-r:'~** (9191549·2000 £xceffenC9 ,,1 ?erformance Pride inAchievement ItHEANATIOHAL lEtt:':JIU'.!Bi;Fl**4C19a:3~8-;'I.EWERRACi<** !'PC RTP INTERNATlONl.( DISIHlfiVl:01**St:RVICf~,** rt'_i!**rjU!.'e~R ~;}S93!7.:._NSVi::f'B/,C"-.I.pc:** **<)~** 

# 40

# . u,s. ENVIRONMEr-..,.AL PROTECTION AGESCV EPA kg**N~mbcr:** D:nt ,,(**1",,3Di;~' .;~tOn-A-"t:**  orr"t of PcstlCide PIOg!'l.llli 

## 264-380**~gi,tnlk,"** Oivi';"m i1l7505C) 

## Jlt 

## 17 1997 

# '111>", 401 OM" 

### s(. 

### sow.

# t~} W;I.\hinglOn. 0 C 11)1.61) Tam of h,u:lOCt': 

## Unconditional NOTICE OF PESTICIDE,



# --- Registration _X_ 

### Reregistration Name ,,( I'e::o;icidt I'nx!ul:t: 

### Prep (Uootl FlFRA. :u amended) 

### brand 

## Ethephon plant 

## Regulator for Cotton

N;um, and**Add,<::s~** ,,(**R~giltr.Ul(** iirn:lude ZIP Cootl: 

## Rhone-Poulenc Ag 

## Company P.O. Box 12014, 

## 2 T.W. 

## Alexander 

## Drive Research Triangle 

## Park, NC 27709-2014

Nott: Changes in labc1ins differing in**.ubs~** (rum WI..:ce;md in eontI«lion with thit fqisU'3lion I\'IlISI hi:**~ubl!liuW** ro 3Il<.I**~** by the Rq:islIation Divif;ion prior 10 USt ofthe label in CQIIIIIlC\ec. In;my**co~po~** O<l this producclllwBys rd

... 10**the;Wo~** EPA "'lisLrllloo lIIIrnbeT. On !he bad.! of inform.>lwn furnished b}' !he fQ:'lSlf.llll. the**,*",~t** Il:1IIWd pellidd<- i< lie/roy**rq:i1lCrcdlrtTq:is~rood** under the Ped<Tal'lliedicWc, Fungicide:md 

# • RO<kntiI:ide Act. Rqistr.llion is in no way 10 I>t """"Irut<!",**~n** tndonemc:rn 01 rttOffilIlCfl<Wion ofmis ",,>ducl by lhe Agency. In order 10 proo:.:t h

... hh;wi lbc CllvimllItl!:rn, the AdminiHl1l!Or, on his OIO\lon. In.!.y at lUly liJfl':**IU~pt"nd** 0/ clU}I;d the**regislT~uon** ofa pt"Sliddc in acrocd1Lnce' wlm the Act.**The;ICC~** ofany rwuc: in COflMdion

....lm 11M: rq:isuation of**~** plDduu undcr \his ACI is 00110 be lOl'Ilnruro ;\S giving the regiSlfMI a rigb'i to uclmi,cuse oflbc II:UI\C or to its USc Ifit Iw. b«n «'Wert<! by othm. 

### Based 

### on your response 

### to the Reregistration Eligibility Document, 

## EPA has reregistered 

### the product listed above. Enclosed 

### is a copy 

### of your label stamped UAccepted. n 

### This action 

### is taken under 

### the authority 

### of section 

## 4 (g) (2) Ie) 

### of the Federal Insecticide, Rodenticide Act, 

### as amended. Reregistration under this section does 

### not eliminate 

### the need 

### for continual reassessment 

### of pesticides. 

## EPA may require submission 

### of data 

### at any time 

### to maintain 

### the registration 

### of your product. 

# •

Sigr.:o!ull' ofApplo'lng OfrKi:1l' 

# lsi Owe: 

## Jll. 17 1997



# 41

# PREPTM brand Ethephon PLANT REGULATOR FOR COTTON FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. NOT FOR RESIDENTIAL USE. ACTIVE INGREDIENT:

Ethephon (2-chloroefhyl) phosphonic acid"

..............................,......,............"

............................ >< ••••••••••••39.9% 

### INERT INGREDIENTS:

...........................................................................................................................60.1 % "This product contains 4 pounds ethephon per gallon. 

### EPA 

### Reg. No.**264~380** 

### EPA Est. No. 264-PA-01 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO

Si usled no entiende la eliquela, busque a alguien para que se la explique a usled en delalle. (If 

### you do not understandthe label, find someone to explain illo you in delaiL) 

### .nF'coirrIMilJ[eDpjjl

# C[AAi:L~AAin"dliTjjR~AilNVS~P~O[iiB~T~A~T~I~0~NQEfim".;;r~ge:enn:cC1i~e.SlQ:i'N~L~Y"cC~a~II-:2~4~H~o~u~r.itAn:Diii.~Y-,1f..:aBO:OO;;:.:a3a:344-."775if77;7r For PRODUCT.!J.S.E. Information Call 1-800-334-9745 The use of fhis product lor a variefy 01 plant growth regulalion uses is covered by United States and foreign patents including U.S. Patent 4,240,819. No license is granted to use this product in countries other than the United States or for any use not contemplated by this label. Liability for patent Infringement may**resu~** lrom use or sale offhis product outside the United States, 

## FIRST AID IF IN EYES: Hold eyelids open and lIush with a steady, gentle stream 01 water for at least 15 minutes. Get medical attention, preferably an Ophthalmologist. IF ON SKfN: Immediately wash with plenty of soap and water. Get medical attention. IF SWALLOWED; Do not Induce vomiting. Promptly drink a large quantity of milk, egg whites. gelalin solution or if these are not available. drink large quantities of water. Avoid alcohol. Call a physician or Poison Control Center. NOTE TO PHYSICtAN Treat symptomatically. Consideration should be given to the possibility that overexposure to materials other Ihan this product may .aveoccurred. No specific antidote is available. Probable mucosal damage may contraindicate the use of gastriC lavage. 

## PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS Corrosive. Causes irreversible eye damage and skin irritation. Harmful if swallowed or absorbed through skin, Do not get In eyes. on skin, or on clothing. Harmful or tatal it swallowed. Avoid contamination of food. 

### PERSONAL PROTECTIVE EQUIPMENT (PPE) Applicators and other handfers must wear long-sleeved shirt and long pants. chemical resistant gloves (such as Nitrile. Butyl. Neoprene and/or Barrier laminate). shoes plus socks and protective eyewear. : ••• When handlers use closed syslems, enclosed cabs, or aircraft in a manner that meets the requirements lisled in 

## the\t<orker Protection Sfandard (WPS) for agricultural pestfcides {40 CFR 170.240 (d) (4-6)), the handler PPE**requlreme~s .,.;a:~**  be**reduc~d** or modified as specitied in the WPS. • • : ••• :. 

### •••••• • Discard clothing and other absorbent materials that have been drenched or heavily contaminated wiftl'lhi" prod4PJ'§ corcenlrate. Do not reuse them. Follow manufacturer's Instrucfionsfor cleaning/maintaining PPE. If no such instrucJio£li for washables,.use detergent and hot water. Keep andwash PPE separafely from othar laundry. •• •• •• 

# iACCEPTED JJl. 

## 17 1997 ••••• 

### •


# ... •• •

•••• ••• 

### • 

## ••



# .. 42

### User Safety Recommendations Users should wash hands belore eating. drinking. chewing gum, using tobacco or using the toUet Users should remove clothing immediately if peslfcide gets Inside. Then wash thoroughly and put on clean clothing. Users should removo PPE immediately anor handling this product. As soon as possible. wash thoroughly and change into clean clothino, Wash the outside of aloves belore removina, 

## ENVIRONMENTAL HAZARD Avoid spray drilt 10 nearby crops as this product may cause temporary modificaHons in planl growth. Do not contaminale waler used lor irrigation or domestic purposes. Do not apply dirocUy to waler, or 10 areas where surface water is present orto intertidal areas below the mean high water mark. Do not contaminate weIer when disposing of equipment washwalers. Do not exceed the rate of PREpl" brand Elhephon Plant Regufalor lor Cotton per acre per year recommended on this label. 

## SPRAY DRIFT Avoid spray drift. Do not apply when weather condilions may cause drift. Do nol arlow this producl to drift on 10 non-targel areas. Drilt mayresull in illegal residues or inrury 10 edjacent crops and vegelalion. in the lorm of leal yellowing and deloliaHon. To avoid spray drill, DO NOT apply aeriallY when wind speed is greaterthan 10 mph orduring periods 

### 01 temperature inversions. Use 

### 01 largerdroplet

• size will also reduce spray drill. AVOIDING SPRAY DRIFTATTHE APPLICATION SITE IS THE RESPONSIBIUTY OFTHEAPPLICATOR. The interaction of many equipment-and-wealher-related faclors determine Ihe pOlential for spray drift. The applicator is responsible for considering aillhese lactors when making decisions. The following drift management requirements must befollowed to avoid olf-target movement from aerial applications 10 agricullural lield crops. These requirements do not apply to loreslryapplicattons. public heallh uses orto applicaHons using dry formulalions. t. The dislance ofthe outer mosl nozzles on Ihe boom must not exceed 3/4 the length ofthe wingspan or rotor. 2. Nozzles must always point backward parallel with the air stream and never be pOinted downwards more than 45 degrees. Where states have more slringent regulations. they should be observed. The applicalorshould be familiarwith and lake inlo accounllhe inlormation covered in IheAerial Drill Reduclion Advisory below: 

## AERIAL DRIFT REDUCTION ADVISORY [This section is adVisory in nature and does not supersede the mandatory label requirementsJ. INFORMATION ON DROPLET SIZE The most effective way to reduce drilt potentIal is to apply large droplets. The best drifl management slrategy is to apply the largest droplets thaI provide sufficient coverage and conlrol. Applying larger droplets reduces drill potenlial, bUI 

### will nol prevenl drin if**~ppllcaHons** are made improperly. or under unlavorable environmentat conditions (See Wind, Temperalure and Humidity, and "II!'femperature Inversions). CONTROLLING DROPLET SIZE Volume

- Use high flow rate nozzles to apply the highest practical spray volume. Nozzles wilh higher rated flows produce larger droplets. Pressure

- 

### 00 nol exceed Ihe nozzle manufacturer's recommended pressures. For many nozzle types lower pressure produces larger droplets. When higher Uow rates are needed, use higher lIow rate nozzles instead of increasing pressure. Number

### 01 nozzles

- Use the minimum number of nozztes Ihat provide uniform coverage. Nozzle Orientation

- Orienting nozzles so that the spray is released parallel 10 the airslream produces larger droplets Ihan other orientaUons and ls the recommended practice. Slgni/lcanl deflection lrom horizonlat will reduce droplet size and increase dritt potential. Nozzle Type

- Use a nozzle type that is designed lor Ihe intended application. With most nozzle types, narrower**sp~angles** produce larger droplets. Consider using low-drift nozzles. Solid stream nozzles oriented slraight back produce the larSlillodroplels and Ihe lowest drill. •••••• • BOOM LENGTH 

# • •• • • • 

# • •••••• For some use patterns. reducing Ihe effective boom lenglh to less Ihan 3/4 

### 01 the wingspan or**roto:T~~lh** may lurlher reduce drift without reducing swath widlh. •• •••• : 

### ••••• 

## •• APPLICATION HEtGHT ••:... • Applications should not be made at a heighl grealer Ihan 10 leet above Ihe top 01 the targel plants unless a grealer.neight is required lor aircrafl salety. Making applications I'll the lowest height that is sale reduces exposure 

### 01 droplets 10**evaporat~!ant!wind.** 

### ••• 

## • ••



# ..

43SWATH ADJUSTMENT When applications are made with a crosswind, the swath will be displaceddownwind. Therefore, on the up anddownwindedges 01 the field, the applicator should compensate lor this displacement by adjusting the path oltha aircraft upwind. Swath adjustment distance should increase, with increasing drill potential (higherwind, smaller drops, etc.). 

### WIND Crm potential Is lowest between wind speeds 01 2 • 10 mph. However, many factors, including droplet size and equipment type determine drill potential al any given speed. Application should be avoided belOw 2 mph due to variable wind direction and high inversion potential. NOTE: Local terrain can influence wind pattems. Every applicator should be familiar with localwind patlerns and how they allect spray drift TEMPERATURE AND HUMIDITY When making appllcalions in low relative humidlly, set up equipment to produce larger droplets to compensale lorevaporation. Droplet evaporation is most severewhen conditions are both hot anddry. TEMPERATURE INVERSIONS Applications should not occurduring a temperature inversion because drift polential is high. Temperalure inversions restrict vertical air mixing, which causes small suspended droplets to remain in a concentrated cloud. This cloud can move in unpredictable dlreclions due to the light variable winds common during inversions. Temperature inversions are characterized by increasing temperatures with altitude and are common on nighls wilh limited cloud cover and light to nowind. They begin to form as the sun sets and often continue into the morning. Their presence can be indicated by ground log; however, il fog is not present. inversions can alsO be identified by Ihe movement 01 smoke from a ground source or an aircraft smoke generator, Smoke that layers and mOves laterally in a concentrated

• CIOUd (under low wind conditions) indicates an inversion, while smoke that moves upward and rapidly dissipates indicates good vertical air mixing. SENSITtVE AREAS The pesticide should only be applied when the potential for driltto adjacent sensitive areas (e.g. residential areas, bodies 01 water, known habitat lor threatened or endangered species, non·target crops) is minimal (e.g. when wind is blowing awayfrom the sensitive areas). 

## DIRECTIONS FOR USE tt Is a violation of Federal law to use this product In a manner Inconsistent with Its labeling. Do not apply this product In a way that wilt contact workers or other persons, either directly or through drift. only protected handters may be In the area during application. For any requirements specfflc to your State or Tribe, consult the agency responsible for pestlctde regulations. Read entire label before using this product.

Usethis product only in accordancewith its labeling andwith theWorker Protection Siandard, 40 CFR par1170. This standard

# '''','.al'051**;~:~~!;:'.~** lor the protection ot agricultural workers on larms, lorests. nurseries, and greenhouses, and handlers of agricultural II contains requirements lor training, decontamination, notification, and emergency assistance. It also contains specific i and exceptions pertaining to the statements on this label about personal protective equipment (PPE), notification workers and restrlcted·entry interval. The requirements in this box only apply to uses ot this product that are covered by the 

## W."ked Protection Standard. Do not enter orallow worker entry inlo treated areas during the restricted·entry interval (REI) 01 48 hours. The REI is 72 hours in areas where average rainfall is lessthan 25 inches peryear. PPE lor early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with been treated such as plants, soil or water is covaralls over long·sleeved shirt and long panls, chemical resistant gloves. chemical resistant lootwear plus socks. and protective eyewear. For overhead exposure, also required.


### GENERAL INFORMATION 

## •••• A foliar spray 01 PREPfM brand Ethephon Plant Regulator tor Colton will accelerate opening of mature**unop~!l""** colton bolls and enhance**del~li~tion** which can result in earlier harvest with an increased recoverable yield.**PREP,:.~ri~~** Ethepholltreatment allows increased effiCiency lrom a once·over harvest. • •• 

## • 

# • • • Some premature drop 01 small, immature bolls may be associated with trealment. Do not apply**WQ~** iufficieOit,·ItttIf'ure, unopened bolls have daveloped 10 produce Ihedesired yield ofcolton. • ••• •••• A bollis maturewhen it is too hardto be dentedwhen squeezed between thumb andtingers, too har{i.1JAl6l slicedwith*'a.fharp knife, and when the seed coat becomes light brown in color. ..:...• • For best results, thorough and uniform spray coverage is required. It is essential that the bons are contacted my tlte spray to obtain optimum boll opening. Observe treated lields closely. Harvest at optlmun bon opening and defoliation,**generallv~1b** 21 days alter Ireatment. Sustained cold weather with average day and night temperatures of 65"F or lower after treatmollt.

....ith,fREPIM brand Ethephon will delaythe boll opening response. • .: 

# 44DO NOTAPPLY PREpN BRAND ETHEPHON IF RAIN IS EXPECTED WITHtN 6 HOURS. Rainlall within 6 hours of application may reduce product performance. CertIfied cotton seed growers should observe bon and seed maturity belore treatment with PREpT" brand Ethephon. Bolls not completely mature might open with trealmenl 01 PREPTM giving lower quality seed. tMPORTANT: Do not apply PREpr

... brand Ethephon through any type of irrigation syslem. 

### SPRAY PREPARATION Add 1/2 fo 3/4 ofthe requIred amount ofwater to the spray lank. Start agitation. Addthe required amount 01 PREP'''' brand Efhephon, and the remaining amount of water. Prepare only as much spray solulion as can be used on the day of mixing. Do not anow spray solution to stand ovemlght. Do not spill Ihe concentrated product on spray equipment, or any airplane parts. ANY SPILLS SHOULD BE RINSED IMMEDIATELY WITH PLENTYOFWATEA. Use 01 a nurse tank is highly recommended loravoiding possible spills of concentrated lormulation on spray equipmenl orany airplane parts. 

### eQUIPMENT CLEANING Spray deposits of PREP'" brand Ethephon ,when lett on aircraft acrylic plastic type windshields lor longerthan t hour, may react with this material, forming an opaque tilm orspots on the surface which cannot be removed bywashing wilh wateror any other cleaner. Rinse windshietds with water immedialely after each tankload of PREpw has been applied. Thoroughly rinse the aircraH with clean water aller each day PREPThI is applied

.
• PREprM brand Ethephon may also affect certain paints, and if accidental deposits on painted objeclS such 

### as cars, trucks, agricultural equipment. efc. occurs, these obiects should be rinsed with water as soon as possible (within 1 hour) to prevent permanent staIning 01 the painted surface. Because otthe acidic nature 01 this producl, prolonged exposure to spray deposit will damage acrylic plastics. certain paints, and metals. Rinse Ihoroughly with a detergent and water all exposed acrylic plastic-type materials (e.g., aircrart windshields), and painted surfaces within an hour after exposure to spray deposits. AI the end 0/ each day, rinse thoroughlywith a delergent and water all the metal parts 01 the aircraft and the associaled spray equIpment exposed to the spray deposits. 

### BOLL OPENING

CONDITIONS EXPECTED 5·7DAY$AFTER TREATMENT Hot and dry 80'For higher

• Dry wilh temperature 75'F10SO'F Cool but higherthan 65'F Rank collon Rates
PAEpN QUARTS/ACRE

1.0 (1.0 Ib a.i.) 1.5 (1.5 Ib a.i.)
2.0 (2.0 Ib a.1.) 2.0 (2.0 Ib a.1.) 

### FQ[ Boll Opening ONE GALLON $PRAYVOLUME

OFPREpTM 

### !3ALJAQBe:

TREATS GROUND AIR 4 Acres t5to 50 2to 5' 2.5 Acres t5to 50 2 to 5'

2 Acres t5t050 2 to 5' 2 Acres 25to 50 5 'NOTE: For California and Arizona use a volume of no less than 5 ganons per acre loraerial applications 

### Tiroe of Application (Boil Opening) Apply when there are sufficient mature unopened bolls to produce the desired yield, but no laterthan when 60% 01 the bolls are opened (see General Information section on how to test for boll malurity). Do not tank mix PREpT" brand Ethephon with a desiccant il the collon is to be spindle harvested.



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# 45

### PRECONDITIONING FOR DEFOLIATION 

### Rates For preconditioning For Defoliation

CONDITIONS EXPECTED ONEGAUON SPRAY VOLUME 5·7 DAYS AFTER PREPfM OFPREPn.· GAL.lACRE TREATMENT QUARTS/ACRE TREATS GROUND 

### AIR Hot and dry BO'F or higher 0.5 (O.S Ib a.i.) BAcres 15to50 2t05' Cool but higherthan 6S'and 1.0 (1.0 Ib a.i.) 4 Acres 15 to 50 2 toS" also for rank cotton 'NOTE: ForCalifomia and Arizona use a volume of no less than 5 gallons per acre for aerial appHcations. 

### Time of Application (Preconditioning) Apply PREprn brand Ethephon 4 to 7 days prior to application of defoliant ortank mixed with the defoliant (see section on Compatibility), Do not tank mix PREP"" with desiccants unless plant desiccation is required. 

### Pre-treatment With Defoliants 

### prior to PBeprn Treatment

• f the cotton Is overly rank or laying down in [he middles and good spraycoverage of the bolls with PREprM brand Ethephon is diflicu[[, a pretreatment with defoliantswill be useful to improve boll coverage with PREpT1>I. Use dosage rates of PREp¥M recommended for boll opening. Read and observe atl appropriate [abel use directions and precautions for the defoliant used. Do not use a defoliant before there are su[fiCient mature unopened bolls to produce the desired y[eld (see Genera[ Information section on how th test for Bo[[ Maturity). 

### COMPATIBILITY PREE=' brand Ethephon is compatible with DEF, FOLEX, DROPP, HARVADE, METHYL PARATHION, GUTHION AND MALATHION, and may be applied in sequence or as a tank mixture (DO NOT TANK MIX WITH DEFOLIANTS OR DESICCANTS IN CALIFORN[A AND AR[ZONA). [n some cases slight reduction in boll opening response has been observed when tank mixeswifh defoliants were used. Good agitation in the spray tank is essential and a tank mixture should not be allowed to stand without agitation for more than 5 to to minutes. Read and observe all appropriate Iabe[ use directions and precautions for the defoliants and insecticides used. PRECAUTfON: NOTE: UNDER CERTA[N CONDITIONS, TANK M[XTURES OF PREP"'" BRAND ETHEPHON WITH DESICCANTS CONTAIN[NG SODII,lM CHLORATE COULD RESULT [N THE FORMATION OF HYPOCHLOROUSACIDS WHICH ON HEATING WILL EMIT TOX[C CHLORIDE FUMES. DO NOT MIX PREprn BRAND ETHEPHON W[TH AMMONIUM THIOSULFATE, SUCH TANK MIXTURES MAY RESULT [N FORMAT[ON _OFTOX[C FUMES. 

### WHEN TO HARVEST: Do not harvest cotton sooner than 7 days after a treatment with PREpI'M brand Ethephon. Observe the treated crop and harvestwhen optimum bon opening has been reached. Too early harvest might reduce the full advantage of the treatment and too late a harvesf may result in reduced quality and loss of lint which will dropfrom the plan!. 

### USE LIMITATIONS
• Do not exceed a maximum of 2.0 lb. ethephon active ingredient per acre per year through combined or repealed uses of any ethephon products.
• Boll Opening: Do not tank mix PREP'" brand Ethephon with a desiccant ifthe cotton is to bespindte harvested.
• Pre-Condition for Defo[iation: Do not tank mix pREP'" brand Ethephon with desiccants unless plant desiccation is required. Do not use a defoliant before thero is sufficient mature unopened bolls to produce the desired yield {see Genera[ Information section on how to tes! for bon maturity.
• Do not plant another crop within 30 days aftertrea[men\. 

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# 46

### USE PRECAUTIONS Avoid spray drift to nearby crops as this product 

### will cause modifications in plant growth. Plant injury or reduced yields 

### wilt result Mix only the amount ofspray you expectto use each day. Do nol allow mixed solution to stand overnight. 

### STORAGE AND DISPOSAL STORAGE Do nol contaminate waler, food, or feed by storage or disposaL 

### PESTICIDE DISPOSAL Pesticide wastes are acutely hazardous, Improper disposal of excess pesticide, spray mixture, or rinsata 

### is a violation of federal law. If Ihese wasles cannot be disposed of by use according to label instructions, contactyour Slate Pesticide or Environmental Control Agency or the Hazardous Waste representative altha nearest EPA Regional Office for guidance. 

### CONTAINER DISPOSAL Triple rinse (or equivalent) the empty containers. Then oUer for recycling or reconditioning, or puncture and dispose of In a sanitary landfill, or by incineration or it allowed by state and local authorities, bv burning, II container is burned, stav out ofsmoke. 

### LIMITED WARRANTY AND DISCLAIMER _rhemanufacturerwarrants (a) thatthis product conforms to Ihe chemical description on the label; (b) !hat this product is reasonably fit tor the purposes set forth in the directions for use when it is used in accordance with such directions; and (c) that the directions, warning and other statements on this label are based upon responsible experts' evaluation of reasonable tests of effectiveness, of loxicity to laboratory animals and to plants, and ot residues on food crops and upon reports ot field experience, Tests have not been made on allvarieties or in all states or underat! condilions. THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES. EXPRESS OR IMPLIED, AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OFTHIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL DIRECTIONS. WARNINGS OR CAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABiliTY FOR ANY AND ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OFTHIS PRODUCT, WHETHER OR NOT BASED IN CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR OTHERWISE SHALL BE LIMITED, ATTHE MANUFACTURER'S OPTION, TO REPLACEMENTOF, ORTHE REPAYMENT OFTHE PURCHASE PRICE FOR, THE QUANTITY OF PRODUCTWITH RESPECT TO WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL. INDIRECT OR _CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OFTHIS PRODUCT.

Rh6ne·Poulenc Ag Company P.O. Box 12014, 2 T.W. Alexander Drive Research Triangle Park, North Carolina 27709 

### •••••• 

## • •• • 

## • •••••• • •



## •• PREP is a trademark of RHONE·POULENC, ••••• PREplM brand Ethephon Plant Regulator for Colton (PENDING) Submitted 1116196, Resubmitted 4/1Jat•• 

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# 47

# , •



# •

• RHONE·POULENC AG COMPANY



### EPA Correspondence No. GSP/eth/044 April 17, 1997
U.S. Environmental Protection Agency Office ofPesticide Progmnls Document Processing Desk (H7504C) Room266A, Crystal Mall 2 1921 

### Jefferson Davis Highway 

### Arlington, V A 22202 Attn: Ms. Cynthia Giles Parker (PM No. 22), •••••• 

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## ••

RE: EPA Reg.iND.**264~380** 

### PREp"fM brand Ethcphon Plant Regulator For Cotton; Label 

### revisions in response to yourcorrespondence of March 27, 1997.
DearMs. Giles

- Parker.
I

### amSUblllilting five copies ofa draft label with the corrections which you requested in 

### your March 27, 1997 correspondence. 1have highlighted the changes onone ofthese labels to facilitate your review.
The following changes huve becilinilde:
Hazards to Humans Section: Replaced text with recommended wording

. Statement ofPractical Treatment Section: Chm1ged title to "FIRSTAID" Deleted "IfIllimled" Statement Ifou Skin: added: "Get medical auention." IfSwallowed: added "Call"physician orPoison Control Center". Ifin Eyes: Chauged Get Medical

...0phthalmologisI" 10 lowerCilse.
Note to Physician Section: Added: "Treat symptomatically. Considerationshould be 

### given to the possibility thut over exposure to materials other than this product may have occurred. No specific antidote is available. Probable mucosal damage lllay contraiudicate the use ofgastric iavtlge." Tllis statcmCllt complies with your input and was rccOinmended 

## by oilr corpOr<1te physician as appropri.ne for all ethephon labels. Deleted: Entire prior statement. Deleted Note to 

### Physician section froll1 the Hazards to Humans Section

PO BOX 120 [4.;> TW ALn<Al·1Q[fl OlliV[ RESEARCH TRIMjGLE PARK, N C ;>77C0·20**[~** (919)549·2000 Excellence 

### In Performance Pride in Achievement [NTERUATIOUAlIELrX NUMl!€1l**~9'YJ37nNjSl'lnlRACK** APe f1TP INTEANATIONAL DISTRIBUTION SHIVICES ffl.EX NUMBER**4!?J'J37;·M~SWErl8!<CK** APC IDS 

# 48

----------

# •

• PPE Section: Modified glove statement to meetcurrent requirements. 

### Environmental Hazards Section: Deleted: "Forterresuial uses". 

## Ingredients: Lined up decimal**poinl~.** 

### •••••• 

## • •• • • 

### •••• 

## •**~**

# ...

• • • 

# ....... •••••• • 

## Directions for Use section: ••••**~...** 

### Removedfirst par:tgraph from Agricultural Use Requirements**bO~lQ.t£xt** 

### above·.: box. ..:... •
Use Limitations section: Modifed 2.0 lb

## ai/A statement as suggested.
Ifyou 

### haveany questions concerning this matter, J

### can 

## be reached at**919~549-2687**

### .

# ~~ Gail Powell, Ph.D. Registration Manager 

## • •• •• 

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•••• ••• 

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••



# 49

# •

• CERTIFIED MAIL Gail Powell Ph.D

. Rhone-Poulenc Ag Company P.O. Box 12014, 2 T.W. Alexander Drive Research Triangle Park, NC 27709 Dear Dr. Powell: Subject: 

### Reregistration**/I~H** 

## 27 1997

PREP brand Ethephon Plant Regulator For Cotton EPA Registration No. 264-380 Your Submissions Dated January 16 and March 13,1996 

### We cannot accept your labeling submitted for reregistration ofethephon until you submit five (5) draft labelswith the following corrections: 

### 1. Update the Hazards to Humans section so it 

### reads as follows: Corrosive. Causes irreversible eye damage and skin irritation. Harmful 

## if swallowed or absorbed through skin. Do not get in eyes on skin or on 

### clothing. 2. In the Statement of Practical Treatment Section you may delete the IF INHALED: 

### section since this product is in Toxicity Category IV for inhalation toxicity. At the bottom ofthis section modify the NOTE TO PHYSICIAN to read: 

### Probable mucosal damage may contraindicate the use of gastric lavage. 3. In the IF ON SKIN section add: Get medical attention.



# 52

# •

• -2- 4. Modify the If Swallowed section to include: Call a physician or Poison Control Center 5. Delete the Note to Physician section in the Hazards to Humans section. 6. In the Environmental Hazards Section delete "For terrestrial uses,". Refer to PR Notice 93-8. 7. In the ingredient declaration assure when the label ',s printed that the decimal 

## points are aligned on the same margin. 8. Move "Do not apply this product in a way
....agency responsible for pesticide regulations" out of the Agricultural Use Requirements section to immediately below the heading "It is a violation of Federal.

...with its labeling." 9. Modify the Use limitation so it is clear that the maximum that can be applied to cotton is 2.0 lb. ofethephon as active ingredient per acre from all sources ofethephon not just this product. Submit the labeling refiecting the above mention changes to the Agency for review 

### within fifteen (15) days of receipt ofthis letter. Failure to do so will result in issuance of a Notice of Intent to Suspend your product's registration.

cc: Wanda Daughtry Judy Loranger 

### Reregistration Branch Sincerely,

Cynthia Giles-Parker Product Manager (22) Fungicide-Herbicide Branch Registration Division (7505C)

Special Review and Reregistration Division (7508W)



# 53

# PREPTM brand Ethephon PLANT REGULATOR FOR COTTON FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. NOT FOR RESIDENTIAL USE. r 

### ACTIVE INGREDIENT: 

# J

E,hephon**(2~chloro9thyl)** 

### phosphonic acid-

.......................................,.................................,.,...•...........

### 39.9% 

### INERT INGREDIENTS:

.........................................................................................................................**60.1~** 

### -This product contains 4 pounds ethephon per gallon. 

### EPA Reg. No. 264·380 EPA Est. No.**264·PA·Ol~** 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
Si ustGd no entiende 

### Ia etiqueta, busqU8 aalgulon para.quo so laexplique a usted en dGtalle. (Ifyou donot understand tho 

### 1abcK, find someone to explain 

### itto you in detaH.)

# ~FoOirr:MM]EiiD]jIC:;;AruLDAr.;nidd-:I~B~A~Ntrn;S~P~O~B~I~A~T~IO~N:E~mm.e.r~gj;i.iincCiI~ ••

# SioijN~Li:Y~C5i.~IIC22:4~H~o~u~r.~A;'oDa;.Y~I:j.Biioo-i(j:i3i3344-'i7S**57~7r** For PRODUCT.u.s.e. Information Call 1

..800

..334

..9745 The use 01 this product for a variety of plant growth regulation usa. is covered by United States and 'oreign patents including U.S. Patont 4,240,8t9. No 

### licans. is granted to use this product in countries other than the United Slates or lor any use 

### not contemplated by this labol. LIability for palont infringamant may rasult from usa orsale ofthis 

### prodoo outside the United States. 

# STATEMENT OF PRACTICAL TREATMENT IF IN EYES: Hold eyelids opon and flush with a stoady. gentle stream ofwatorfor 

### at least 15 minutes, GET MEDICAlATIENTION. PREFERABLYAN 

### OPHTHAlMOlOGIST, IFON SKIN: Immediately**~h** with plenty of soap and water. IF SWALLOWED: 00 not indoco vomiting. Promptly drink a large quantity of milk. egg whites, gelatin solution or if these aro not available. drink large quantitioeofwater. Avoid alcohol. 

### catI a physician immediately. IFINHALED: Remove victim to fresh air. If not breathing; give artificial respiration. Administer oxygen if nGCOssary. GET MEDICAL 

### ATTENTION. NOTE TO PHYSICIAN

# ~ specilic antidote is available. All troatmants should 

### be basad on obSIiUVed signs and symptoms of distre

.. In the pationt. 

## C

\**erexposur~.to** materials otherthan this product may have occurred. lalms of severe overexposure. 

### by Inhalation, should 

### be kept under medical observation for 

### up to 72 houra for delayed on"t of

, 'l pulmonary adema. In a 

### victim of overexposure by Ingestion. careful gastric lavage 

### is required duo to tho possibility of stomach or esophageal perforation. This material 

### Is an 

### acld, butthe usa of alkaUno sub&tancaa

### to nautrali.ul 

### it is contraindicated. 

# PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS Corrosive. Causes eye damage and skin Irritation, 00 oot got in eyes, on skin, or on 

### dothlng. Harmlul orfatal if swalloWed. Avoid oontamination of food. 

### NOTE TO PHYSICIAN 

### •••••

## • • •• • 

## • •••• • •



### •••• • 

## • 

## •••••• • 

## • •• 

## • •• 

## • No spocific antidole is availablo. All treatments sllouid 

### be based on obselVed signs and symilT&rfll:of dlsfr.s5·ln the patient, Ovorexposure to materials otherthan this product may have occurred. •• •• • : 

## •• ••• •••• VICtims of sever. overexposure, 

### by inhalation. should 

### be kept undOf medical observation for up

## "0!Aa. Ftours for delayed onset of pulmonary odema. In a victim of ovorexpo&ure 

### by ingestion. careful gastric lavage 

### is required duo to the,**~bili¥of** stomach Of esophogoaJ perforation. This material is an acid, but the usa of 

### aJkaline substances 10 neutralize 

### it isoontntindicatGu;··•


# 54

## PERSONAL PROTECTIVE EQUIPMENT (PPE) Applicators and other handlers must wear long-sleeved shirt and long panw, waterproof gloves, Sho08 plus 

### socks and protectivG ayawamr. Whon handlers useclosod systoms, enclosed cabs, oraircraft In a mannorthat mootstho requirements listod in tho Workor Protection Standard (WPS) lor agricukural pestlcidos (40 CFR 170.240 (d) (4-6)], the handler PPE requiremants may 

### be reduced or 

### modified as spociliod in tho WPS. Discard clothing and otho, absorbent material. that have boon drenchod or heavfly contaminatod with thla product's 

### concontrato. Do 

### not rouse them. Follow 

### manulact.uror'. instructions lorcleaning/maintaining PPE. "nosuch Instructions lor washable8. use dotergent and hot walor. Koep and wash PPE separatoly from othor laundry. 

## User ::safety Recommendations Us

....should wash hands boforo eating, drinking, chowing gum, ualng tobacco orusing tho tc»lot. Users should romovo clothing immodlatoty if pGstlcldG gots inside. Than wash 

### thoroughly and puton claan clothing. 

### UUr& should removo 

### PPE immodiately att.r handling this product. 

### As soon as possiblo, wash thoroughly and chango Into cIoan clothina. Wash the outside ofolovas**belon~** removina. 

## ENVIRONMENTAL HAZARD Avoid s drift 

### to nearby ct'0p8 as this product may cause temporary modification. in plant growth. 00 

### not contaminate walor used 

## ai9f"- allon or mastic purposes. 'f8Itorterrestrial use 

### ,do notapply directlyto water. or 10 areas wher. surface water Is present orto intertidal areas below tho

### maan/~h I water mark. t contaminate waterwhen disposing 

### of oqulpmontwaahwat8fS.

bo.""'''''coc.ed the rate of

### PREptw brand Bhophon 

### Plant RogulatOf'for

### Cotton per

### aero pery
....recommendod 

### on this 

### Iabot. 

## SPRAY DRIFT Avoid spray drift. Do not apply whGn weatherconditions may cause drift_ Do 

### not allow this productto driftonto non-target are
... Drift may result in Plogal ratidue, or injury to adJacent crops and vegetation, In 

### tho form of Ie

### at yalJowlng and detollatlon. To 

### avoid $pfay drift, 

### DO NOT apply aeriallywhen windspood 

### Is greaterthan to mph orduring periods oftemperaturo inversions. 

### Uao of

### Jargar droplet size 

### wiN also radooa apt'ay drift. 

### AVOIDINGSPRAV DRIFTATTHEAPPUCATJON SITE 

### JS TIiE RESPONSIBtuTYOF 

### TIiEAPPLICATOR 

### Tho interaction of many equipment-and-weather-related factors dotermine the potential

### for spray drift. The 

### applicator I, reaponeibkl for considering 

### aU the'e factotS whon making decisions. Thefallowing drift management requirements must

### befoUowod 10 avoid

### off-target movementfrom aerial applications 10 agricuitural field 

### crops. Those requirements- do 

### not apply

### to forestry appIk:atiomJ. public

### hoahh UMS or

### to appIlcat/ona 

### U1Jiog dryfonnulatlons. 1. The distance ofthe oUier moat nozzlNon tho 

### boom must

### not exceed314

### the kangth ofthe wingspan or

### rotor. 2. Nozzles must always

### pointbackward parallafwith the 

### airstream and never

### bepointed downwards morethan 45 dogr

.... • oore statas have mora Slringent regulations, thoy should 

### beabsOlVed. The 

### applicatorshould 

### befamiliar

### with andtake Into accounttho Information covered fn the Aerial Drift Reduction 

### Advisory below:

### ~~IDAL~~R1FT**REDUCTIO~**

## ...**ADYlSO~L_.~_ ~**  

## t[ThIS section is advisory in nature anddoes 

### not supersede the mandatory label roquitomGirt!D 

### mF'ORMA'RON ON DROPtET SIZE

-

The most effective way to reduce drift potontlalls to apply large droplets. The beat drift management strategy 18 

### to applythe largest droplets that provide sufficient coverage and control. Applying targer droplots reduce. drift**potentla~** but 

### will 

### not prevent drift if applications are made improperly, or under unfavorable onvironmental conditions (See Wind, Temperatur. and Humidity, and Temperatur. Inversions). • ••• 

### • 

## • CONTROLUNG DROPLET StZE •••• Volume

- Use high llow rate nozzles to 

### apply the hlghost 

### practical $pfay volume. Nozzles with higher

### rated;~prodoco largor droplets. 

### •

## ••••• 

## • Pressure

- Do 

### not oxceod the nozzle manufacturers racommended pressures. For many nozzle

# tyPos 4wler prou.uto.produces larger droploa. When highOf' flow rat08 are needed, use higherflow rate nozzles instead ofincreasing prelW.llt.. : •••• Numberof nozz.lea

### ~ Use the minimum numberof nozzles 

### thatprovide uniform coverage. •••• •• 

## • 

# •• Nozzle Orientation

- Orienting nozzles 80 that the spray 

### is released parallel to tho airstroam**~. larger·d'ro~**  than other orientations and is the recommended practice. Signilicant dellection from horizontal wPI reduM·4rbp/et**siz~** $d Increase drift potential. : •••• Nozzle Type**~** Use a nozzlo type that Is designed for tho intended application. WIth 

### moat nozzfe typGt, 

### narrowor

# aP(.y-anglNproduco larger droplets. Consider using Iow-drift nozzles. Solid stroam nozzles oriantod straight 

### bad< prodoco the 

## latJi"cllQPkml and the lowest drift. •,. • 

# 55BOOM LENGTH For some UM patterns, reducing the offective boom length to loss than 

### 3/-4 of 

### tho wlngspatl or rotor length may lurther reduce drift without 

### rGduclng swathwidth. APPLICATION HEIGHT Applications should 

### not be made at a height grealerthan to feet 

### abow the 

### top ofthe target planta unleso a grealer height Is roquirod for aircraft safety. Maklng applications 

### atthe lowest height that is safe r&ducas exposure of dlOplet81o evaporation and 

### wind. SWATH ADJUSTMENT When applications are made with acrosswind, the swath will be displaced downwind. ThGl'oforo, on 

### the upand downwind edges of the field, the applicatorshould compensate for this displacoment 

### by adjusting tha path oftho aircraft upwind. Swath adjustment distance should increase. with increasing drift potential (higher

### wind, smallerdrops, etc.), 

### WIND Drift polential Is lowest batween wind speeds of 2 - 10 mph. Howover, many factors, including droplet size and 8(Julpment 

### type determine drift potential al any given speed. Application should be avoided below 2 mph duo to variable wind direction and high invarslon potential NOTE: Local terrain can influence wind patterns. Every 

### applicator should 

### befamiliar with local wlnd patterns and how they affect spray drift. 

### TEMPERATURE AND HUMIDITY When making 

### appIlcatioll6 in low relative humidity. 

### sot 

### up equipment

### to produce largerdroplets 

### 10 compensate for ovaporation. Droplet evaporation 

### Is most80vere when conditions 81e both hot and dry

. .lEMPERATURE INVERSIONS**~icatlons** should 

### not occur during atemperature invorslon because drift potential is high. Temperature Inversions restrict vortk:al air mixing. which caUSA sman suspended droplata 10 remain In a concentrated cloud. This cloud can move in unpredictable dilections due ' to the light variable winds common during inversions. Temperatura inversions ara charaderilod by Increasing temperaturas with /. akituc.le and are common on nighta with IImitoo cloud oover and lightto no wind. They begin to form as the sun 

### seta and otten continue intotho morning. Their presence 

### can bG indicated by ground fog; howover. if

### fog is not present, inversions 

### can alsobe identifiod bytho movoment of smoke from a ground source or an aircraft smoke genorator. Smoka that layers and movo. lateralt{ in a ooncontratod cloud (under bwwind oonditlona) indicates an inversion, whU. amok.that mov
..upward and rapidly disaipatG8 indlcatoa goodwrtlcal 

### air mixing. 

### SENSITIVE AREAS 

### The pesticide sllould only 

### b. applied whon the potontlal for drift 

### 10 adiacont sensitiva araas (a.g. residential areu, bodlos of water. known habitatfor thr.a!al'\Od or andangered apocioe:, 

### non-targotcrops) ia minimal (e.g. whan wind Is blowing away from tha sonsitiva areas). 

# DIRECTIONS FOR USE**~--;:=:::::=~:Ia~~'_V~Io=I.~t~lo~n~O~'_F~'~d~.~r:al** law 

### to u
.. thla product In a manner Inconslstant with Ita lahellng. /' Read onth tabol boforo usIng th,* product



### not apply this product In a way that wm oontact workers or other persons, either direcUy orthrough drift. Only

## prot"actod:~n:.r:.:~~:1

be in the area during application. For any requirements specific to your State or Tribe. consult the agency 

### n

# !!illi!r~&g1~Uljm~~!ns~.~~~~~li!~~1j~l!i~~ with itsi&beling and with the Worker Protection Standard, 

### 40 CFR part 170. Thia standard I workers on fatms, fetests, nursari

.. , and greenhouses. and handlers of decontamination, notification, and emergency assistance. 

### It on this label about personal prot&CtivG equipment (PPE), In this box only apply to uses of this product that ara covered by the 00 not entorat aJbw worker entry into treatOO areas during the rostrided-ontry interval (REI) of 48 hours. The REI is 72 hours in average rainfall is 1e88 than 25 Inchaa paryeat. • ••_._ required for eatly ontry 

### to treated areas thatla pormittad underthe Womer Protection Standard and that**In~lt**..contact

## 1~;;YiI;II,;;g that has boen treated such a8 plants. 

### SOH or water is covaralls over Iong·sleeved shirt and long

## pantt..~'Wtca'll**:~~~:::~I** as any waterproof gloves. chemical resistant lootwear plus 

### socks. and protective eyewaar. Fort)vorh.ad a headgear 

### is also required.
_


### GENERAL INFORMATION 

## • • • •• A 

### tonal spray 

### of PREPTM brand Ethophon Plant Regulator for Conon**w~1** 8CCGlorate opening of**m·al~ro·**wnopanoa

## cOlton boBs and enhance defoliation which can result In earlier harvest with an increased recovorable yield.**PREPTM~lM** Ethephon tremmant alows Increasod efficiancy from a once-over harvost. : __ •• Some prematuro drop of small. immature bolls may be aasodated with treatment. 00 not apply bolor. sufficient.-maTure. unoponod boHs have developod to produce tho desired yield of ooHon.
_- -:- _ 

# ... 56A boll is mature when it is too hardtobe den10d whon squoezed bGtwoon thumb and fingGf'S, too hard to 

### besliced**w~h** asharp knife, and whoo tho sood 

### coatbocom08 light brown in color. For 

### best results, thorough and uniform spray covorago is required. It is ossontial that tho boUs are oontadod by the spray to obtain optimum boH opening. ObsolVe troated fields cIosoly. Harvost 

### at optlmun bon opening and dofoliation, gonaralty 14

### to 21 days aftar !rammont. Suslainod oold woather with average day and night tomperaturas of 65°F or Iowar aftor troatmant with PREptN brand 

### Elhophon will dalaythe 

### boll opening 

### rosponse. DO NOTAPPLY PREp'IV BRAND ETHEPHON IF RAIN IS EXPEClEOWITHIN 6 HOURS. Rainfall within 6 hours of application may reduce 

### product performance. Cartified coHan seed grower. should ob$afVo boll and sood maturity bofor. treatment with PAEPlW brand 

### Ethaphon. Bolls not oompiGtoly mature mightopon with

### tr88tmentof PREpn!: 

### giving Iowarquality

### nod. IMPORTANT: 

### Do not apply PREPT" bfand Ethophon through any type of Ifriga1lon system. 

### SPRAY PREPARATION AI:Jd 112

### to 314 ofthe required 8Jl'IOUnt ofwatGf

### to the spray tank. Start agitation. 

### Add the required amount of PRE!»" brand Ethephon, and tho remaining amount of water. Prepare only as much spray solution as can be usoo on the day 

### 01 mixing. 

### Do not ailow spray solution to stand o
....rnlght. Do not spill the (XIncentrated 

### product on spray equipm.nt, orany airplane parts. 

### MY SPillS SHOULD BE RINSED IMMEDIATELY WITH PLENTYOFWATER. Us.of

### a nurse tank is highly recommended for avoiding possible spills ofoonoantrmoo formulation on spray equipment Ofany airplane parts. 

### eQUIPMENT CLEANING Spray daposits 

### 01 PREPN brand Bh&phon , when loft on aircraft 

### acrylic plastictype windshields for longerthan 

### 1 hour, may react wflh this materlaJ, forming an opaque film orspots onthe surfacG which cannot be remo
...

### ed by washing 

### with wateror

### any othercleaner. / Rinse windshleld:$ wflh watGf Immedlatoly aft.r .achtankload 

### 01 PREPnI has hoen applied. Thoroughly rinse the aircraft

### withclean / watGl' aftereach day PREptw Is appIiod. PREPN brand EthGPhon may also aifGCt certain paints. and if accidental deposits on palnted objects such as cam, 

### trucks, agricultural equipment, etc. OCCtJrs, the

..ob}octs should be rinsed with water as soon as poosiblo (within 

### 1 hour) to prevent 

### permanont staining of the 

### painted surface. BecaU88 of tho acidic natura of this 

### product, prolonged .xposur. to spray deposit will damage acrylic 

### plastic:8, certain paints. and metals. Rinse thoroughly wflh adetergent 

### andwat.r

### all oxposed 

### acrylic plastic-typo mawrials (e.g., aircraftwindshlolds), and 

### palntocl surfaces withio ao bourafter exposure 

### to spraydeposits. Atthe end of9ach day. rinao thoroughly with a d.tergent and wat.r all tho matal parts oftho aircraft and tho aaGOclatod spray equipment .xposedto tho spray dapoW. 

### BOLL OPENING**~D!T1ONS** EXPECTED

__ 7DAYS AFTER TREATMENT 

### Hot and dry BO'F Of' higher 01)' with tomperature 

### 75'FtoSO'F 

### Bates For Boll Ooenlnp.

PREi"" QUARTS/ACRE t.O (1.0 b a.i.) 1.5 (1.5 Ib

..1.1 

### CNEGAllCN 

### OFPRE'"

TREAlS 4 

### Act

.. 

### 2.5 Acrea SPRAYVOLUME GALlACAE GRQUND AIR t5to 50 

### 15

### to 50 2t05- 

### 2to 

### 5- CootbuthigharthanSS"F 2.0 (2.0 Ib&.i.) 2

# Act.. 151050 

### 2t05· 5 Rank cotton 2.0 (2.0 

### b 

### a.1.) 2 Acres 25 

### to 50 *NOTE: 

### For Califomiaand Arizona usa avoIum. of no i06$ than 5gallons

### per acr.for 8Gfial applications 

### •••• • •



## •••• Time of Application (Boll Opening) 

## • • •••••• 

## • Apply when thor. are sufficient mature unopaned bolls 

### to produce the dGsiTod ylold. but no iat.r**than~eO%**

### ofthoPOIIG: are opened (s8e Gan.ral Information S&CIion on how to t.st for bolt maturity). Do 

### not tank mix PREPm branc(EttfoJ#lon wltO a g.slccant if tho ool1on is 

### to be spindle harv.sted. •• • 

## •••••• • 

## ••

• 

## •

••


# ..-

# ..

• • 

### ••••• • 

### • • 

## ••

•

### ••• 

## • • •• •• •



## •••• •••• • 

### ••



## •• 

## • 

# 57

### PRECONDITIONING FOR PEFOllATIClli 

### Bates Eor Preconditioning For Defollatloo


## CONDnlONSEXPECTED 5-7 DAYSAFTER TREATMENT ONE GAlLON 

### SPRAYVOLUME

Hot and dry aO'F or higher Cool 

### but higherthan 55'and also for rank cotton 

### PA€P"' OUARTS/AcRE 0.5 (0,5 Ib a.i.) 1.0 (1.0 Ib a.L) 

### OFPREI'"' GAl rACAE 

### mEATS GROUND 

### 8kres 15

### to 50 " Acres 

### 15to 

### 50 'NOTE: ForCalifomia and Arizona usa avolume of no 1&81than 5gallons peracra for aerial applications. 

### Time of Application (Preconditioning) AIR 2105" 

### 2105-

Apply PREPrwbrand Ethephon 4to 7days prior to application ofdefoliant ortank mixed with thodGfofiant (sao section on Compatibility). Do nottank mix PREp1'M**w~h** desiccants unless plant desiccaJion is required. 

### pre-treatment 

### With pefollants Prior to 

### PREpN Treatment

• the cotton is overly rank or laying down in the middles and good spray coverage oftho beUs with PAEPD' brand Ethephon 

### isdifficult. a retraatment 

### with defoliants

# wi» be useful to improve

# be" coveraga with PREP'"", Use dosage ratos of PREPN recommended tor boll opening. Read andobserve 

### aUappropriate label use dirGCtions and precautions fortho dQfoliant used. Do not use 

### a defoliant boIora there atO sufficient maturo unopened bolls to produce tho desired yield (see GGnarallnformatlon section on how th tast for Boll Maturity). 

### COMPATIBILITY PREP'"

### brand Elhephon 

### 1s00l11plllblewah DEE. FOLEX. DROPP. HARVADE. METHYL PARATHION. GUTHION AND MALATHION. and may 

### be appIiGd In sfKluonco or as a tank mixture {DO NOT TANK MIXWITH DEFOlIANTS OR DESICCANTS IN CAliFORNIAAND 

### ARIZONA}. In some casas slight reduction In boO opening rosponse has 

### bHncbsarvod whentankmixes 

### with dafollanta

### were U&Gd. 

### Good agitation in the spray

### tank Is oaaential 

### anda tank mixtuf4t should 

### not be allowed 

### to stand without agitation for more than 5 to 10 minute•• Read 

### and obsaMI all appropriate labol use diroctions 

### and precautions for tho defoUanta and insocticidee used. 

### PRECAUTION, NOre, UNDER CERTAIN CONDITIONS. TANK MIXTURES OF PREpN BRAND ETHEPHON WITH DESICCANTS CONTAINING SODIUM CHLORATE COULD RESULT IN THE FORMATION OF HYPOCHLOROUSACIDS WHICH ON HEATING WILL EMIT TOXIC CHlORIDE FUMES. 00 NOTMIXPREI'"' BRAND ETHEPHON WITHAMMONIUMTHIOSULFATE. SUCHTANK MIXTURES MAY RESULT IN FORMATION OF roXIC FUMES. _HEN TO HARVEST, Do not harvast cotton soon.rthan 

### 7 days atter a treatment

### with 

### PREfm'brand Ethephon. Obsorvotho Ireatoo crop and hllVestwhen optimum 

### boD opening has bGon raachOO. 

### Too .artyharvest might rGduce 

### tho fuN 

### advantago ofthe treatment andtoo 

### lat.ahaIvo.t may r.suk in rGducod quality 

### anc:Ilosa of

### Untwhich 

### wiU dropfrom tho 

# tant USE LIMITATIONS •

### ~~~~~ 

# , '. Do not exceed a maximum of2.0 lb. aiJAforcombinod uses

### o~e~1'M mnd Ethophon par'fa"e peryear. Boll Opening: Do

### not tari< mix PREP'"' brand Ethephon with a**desiCCarnif-th~.to--!)8** spindle harvosted. Prft.Condillonfor Defoliation: 

### Do nottank mix PREPN beand Ethaphon with desiccants unless plant dosiccationAWluifad. Do not usa a dafollant before th.r. is sufficient maturo unoponod bolla to produce the dosirGd yield (sae General Infqrpwlbn section on howto test for 

### boH maturity. Do 

### not plant anotharcrop within 30 days aftertreatment 

### •••••• • •• • • 

## •••••• • • • ••• 

## •••••• • •

•• 

### ••••• 

## • • 

### ••••• 

## •• • • 

## ••

• 

## • • ••

•••• • • •• 

## •• •

•••• 

## •••• • ••



## •• • 

# 58..... --.----.-.--.- ..**--.-------------~**



### USE PRECAUTIONS Avoid Ipfaydrift 10 nearby crops asthis product

### wiU cause**mod~icalion8** in plant growth. Plant injury or reduced yields will resU«. Mix only the amount of spray you oxpect

### to USG each day. 

### Do not aUow mixed solution to stand overnight. 

## STORAGI: AND DISPOSAL STORAGE 

### Do notcontaminato water, 

### food, orfood 

## t7t swrage ordispos.aJ, 

### PESTICIDE DISPOSAL Pesticide was10a 818 acutely hazardous. ImPl'opordisposalof excess pesticide, spray mbcturo, or rlnaate is a violationoffoderallaw. Ifthoso wastes cannot 

### bedisposed of by use according to labollnstruction., contact your State Pestlclde or Environmental Control Agoney ortho Hazardous Wast. reprosentative 

### atthe noarest EPA Regional 

### Office for guidallCG. 

### CONTAINER DISPOSAL Triple 

### rinse (orequivalent) tho empty containers. Thon offerfor recycling or reconditioning, or puncture and dispose of In asanitary landfill 

# oriW-lncinoration or if allowed bv stato and local authorities bv bumino. Ifcontainor is burned, slav out of smoke. 

## LIMITED WARRANTY AND DISCLAIMER

••manufacturerW81ranta (8) that this product conform.

### to tho chemical description on the label; (b) that this product

### is r.asonably fll: for the purpose•• et 

### forth In the ditoctlons for use when it Is used In accordanoo with such directions; and (c) thal tho directions, warning and other statements on this labol ara 

### ba&od upon responsible exports' evaluation of reasonable tests: of effectiveness, of toxicity to laboratory 

### animals and to plant., and of residue. on food 

### crops and upon**r~ports** of flold 

### experience. Teats have 

### not been made on all varietloa or in aU state.or underallconditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT
_ 

### AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND 

# ITI EXPRESSLY EXCLUDES

### AND DISCLAIMS

### AlL IMPLIED WARRANTIES 

### OF MERCHANTABILITYOR FITNESS FOR

### APARTICULAR PURPOSE. 

## ,-I THIS 

### WARRANTY DOES 

### NOT EXTEND TO. 

### AND THE BUYER SHAlLBE SOLELY RESPONSIBLE FOR, ANY AND AlL LOSS OR 

### DAMAGE WHICH RESULTS FROM THE USE OFTHIS PRODUCT IN ANY MANNERWHICH IS INCONSISTENTWITH THE LABEL DIRECTlONS. WARNINGS OR CAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SEllER'S EXCLUSIVE UABILITY FOR ANY AND AlL CLAIMS, LOSSES, DAMAGES. OR INJURIES RESULTING FROMTHE USE OR HANDLING OFTHIS PRODUCT, WHETHER OR NOTBASED IN 

### CONTRACT. NEGLIGENCE. STRICT lIABILITY IN TORTOROTHERWISE SHALLBE UMITED.ATTHE MANUFACTURER'S OPllON. TO REPlACEMENTOF. ORTHE REPAYMENTOF THE PURCHASE PRICE FOR, THE OUANTITYOF PRODUCTWITH RESPECTTO WHICH DAMAGESARE CLAIMED. IN NO EVENTSHALL MANUFACTUREROR SElleR BE LIABLE FOR SPECIAl.. INDIRECTOR • CONSEOIJENTW. DAMAGES RESULTlNG FROM THE USEOR HANDlING OFTHIS PRODUCT.

Rh6no-Poukmc

### Ag Company P.O. Box 

### 12014, 2 T.W. Alexander Drive 

### ROS&arCh Trianglo Palk, 

### NorthCarolina 

### 2n09 PREP Is atrademark of RHONE..pQULENC. PREpn. 

### brand Ethophon Plant Regulator for Collon (PENDING) Submitted 1/16196. 

# . ... • 

## •

•••• • • •••••• • •••••• • • •• 

## • • 

## ••• •••••• • 

## •

•• 

## ••••• 

## • • •

### •••• •• 

## • • ••

• 

## • • ••



## ••••
• 

## •• •• •



### •••• •••• • ••



## •• • 

# 59

## DP BARCODE, D233644 CASE, 003340 SUBMISSION, S499336 DATA PACKAGE RECORD 

## BEAN SHEET DATE, 02/21/97 Page 1 of 1



## CASE TYPE, RANKING CHEMICALS, 

## * 

## * * CASE/SUBMISSION INFORMATION 

### * * 

## * REGISTRATION



# o POINTS () 099801 Ethephon 

## ACTION, 674 8 MNTH RESP-PROD SPC DATA

ID#, 000264-00380 PREP PLANT REGULATOR FOR COTTON COMPANY, 000264 RHONE-POULENC AG COMPANY**39.9000~**



## PRODUCT MANAGER, 25 PHILIP ERRICO 703-305-6027 ROOM, CM2 241 PM TEAM REVIEWER, WANDA RUFFIN DAUGHTRY 703-308-8171 ROOM, CS1 1K4 RECEIVED DATE, 01/23/96 DUE OUT DATE, 07/21/96 

## * * * DATA PACKAGE INFORMATION 

### * 

## * 

## ***~** 

## BARCODE, 233644 EXPEDITE, N DATE SENT, 02/21/97 DATE RET., 

## / / HEMlCAL: 099801 Ethephon 

## DP TYPE, 001 Submission Related Data Package 

## CSF, Y LABEL, Y ASSIGNED TO DATE IN DATE 

## OUT ADMIN DUE DATE, OS/22/97

DIV 

# , BRAN, SECT, REVR 

# , CONTR, 

# •

DP BC 226724 226726 RD 

## / 

## / / / NEGOT DATE, 

## / FHB 

## / 

## / / / PROJ 

## DATE, 

## / PMT-22 

## / / / / / / 

## / / / / / 

## / 

# * * * DATA REVIEW INSTRUCTIONS 

## * * 

## * This product is recommended for reregistration upon your final review of label for compliance with Ethephon RED. After label review, please close this data package submission as well as the 674 submission with a reregistration decision and file all correspondence in the 

### product jacket. Thanks Attached: correspondence/administrative product chemistry/acute tox reviews 

## * * * 

### DATA PACKAGE EVALUATION 

## * * 

## * No evaluation is written for this data package



# * * * ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION 

# * * 

## * BRANCH/SECTION RSB/PCRS RSB/PRS DATE OUT 05/31/96 05/31/96 DUE BACK 08/29/96 08/29/96 INS Y Y 

## CSF Y Y 

## / /



# 60 LABEL Y Y

# ..



# •

• . '
DATil ODT. 

## NOV 1**~** 

## 199,

SUlIJIICT. III' [X] lIP [] 

### PIIDDUCT CllBHIBHY ItBVIBlf 

# DP

# BARCODB~jUiO~'iiilil:;~;;~ll~~~;;;;~~;::;l!l!ii RBGIBTIIATIOU PRODUCT: 

## DID TO: 22 Cynthia Giles-Parker/Wanda Ruffin Daughtry 

## Fungicide-Herbicide Branch Registration Division (7505C) PROIl. 

## Sami Malak, Chemist, 11/12/96

# {308-8392)~/111~ Product Chemistry Review Section { 

# '>/ \<.- Registration support Branch/RD (7505W)

. 

# a .r" I' 

## I 

# "..L. (;J 11-'-' 

# jJ..( Harold Podall, Section Head 

# /);J I.

# ~Qj)**p~** Product Chemistry Review Section

## ~ 

# (tvTBRU,



### 1IIiI1IIIGS: 

## 1. The submitted product**ch~mistry** 

## data requirements for reregistration of this end-use product, Ethrel Brand Ethephon Plant Regulator For Cotton, Reg. No. 264-380, is adequate. 

### 2. Product chemistry data requirements pertaining to Series 63, summarized in the table below, is adequate. 

## 3. The submitted product's label EPA received 1/23/96, is 

## acceptable. 4. The submitted product's CSF, a basic formulation dated 

## 12/19/95 is acceptable. All ingredients are cleared for use in pesticide formulations. 

## RlCOHHEHPATIONS: We have no objections to reregister this end-use product, Ethrel Brand Ethephon Plant Regulator For Cotton, Reg. No. 264-380.

7S0SU:RD:RSB:PCRS:CS-1:65D:S.Malak:ll/12/96:703-308-8J92:<264-380>.


# 61

# •

• 2 

## SUMMARYOFPRODUCTCHEMlSTRYDATA REQUIREMENTS OFSERIES63 PHYSICAL/CHEMICAL PROPERTIES.MRIDNo. 439205-07
Gu/DELINE VALUE OR QUALITATIVEDESCRIPTION REFERENCENO/TITLE 63·2 Color Waterc/ear 63-3 

## Physical Stale Freeflowing liquid. 63-4 Odor Odorless 63-7 Densily. BulkDensily. 1.2070 orSpecific Gravily 63-12 pH 2.03 63-14 Oxidizing 

## Or 

## Does not contain oxidizing orreducing agents. ReducingAction 63-15 F1ammabililylFlame NA 

## Extension 63-16 ExpIodabilily **Does not**  **contain** 

## any explosive **materials** 

## 63-17 Storage Stability Stablefora minimum of 2.5years. 63-18 Viscosily 3.331 cSt

. 

## 63-19 Miscibilily (With NA hydrocarlxm Solvents) 63-20 Corrosion 

## Non **cOlTOsive** 

## to stainless steelorplastic. Slight corrosion 

## Characteristics 

## to mildsteel andaluminum. 63-21 Dielectric Breakdown NA Voltage (EP only).

eel Sam! Malak and Central file (Reg. No. 264-380). 75051./:RD:RSB:PCRS:CS-l :650:SMalal:::11/12/96:703-308-8392:<264·380>.



# 62

## OP BARCODE: 0226724 CASE: 003340 SUBMISSION: S499336 DATA PACKAGE RECORD BEAN 

## SHEET 

# * * * CASE/SUBMISSION INFORMATION 

# * 

# * * DATE: 05/31/96 page 1 of 1

CASE TYPE: REGISTRATION ACTION: 674 8 JINTH 

## RESP-PROO SPC DATA RANKING : CHEMICALS: 

# o POINTS 

# 0 099801 Ethephon IO': 000264-00380 PREP PLANT REGULATOR FOR COTTON COMPANY: 000264 RHONE-POULENC AG COMPANY 39.9000%

PRODUCT MANAGER: 25 ROBERT TAYLOR 703-305-6800 ROOM: CM2 

## 241 PM TEAM REVIEWER: WANDA RUFFIN DAUGHTRY 703-308-8171 ROOM: CSl lK4 RECEIVED DATE: 01/23/96 DUE OUT DATE: 07/21/96 

# • * * DATA PACKAGE INFORMATION 

# * 

# * * DP BARCODE: 226724 EXPEDITE: N DATE SENT: 05/31/96 DATE RET.: / / CHEMICAL: 099801 Ethephon CSF: Y LABEL: Y 

# t TYPE: 001 Submission Related Data Package SIGNED TO DATE IN DATE OUT ADMIN DUE NEGOT

PROJ DATE: 08/29/96 DIV:RD // // BRAN: 

## RSB / / / / SECT: PCRS / / / / DATE: DATE:

# ~**~** REVR: // // 

## CONTR: / / / / 

# •

OP BC 

# * 

# * * DATA REVIEW INSTRUCTIONS 

# * * * Please complete 8 month reregistration review of data for 

## product under Ethephon RED (0382). Thanks Citing MRID 43920507 for series 61, 62, and 63 (data attached to 0226722 (product 264-257» PLEASE RETURN TO W.DAUGHTRY, CS1, 3RD FLOOR, SRRD-7508W 

# * 

# * * DATA PACKAGE EVALUATION 

# * * * No evaluation is written for this data package



# • • * ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION • • • BRANCH/SECTION DATE OUT DUE BACK INS CSF



# 63 LABEL

# .,
•



# •

• -_._--------------

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 204G0

MEMORANDUM OFFICE OF PREVENTION, PESTICIOESAND TOXIC SUBSTANCES 

### Subject, EPA File Symbols, 264-263(0226719), 264-543(0226721), 264-267(0226711), 264-292(0226717), 264-376(0226715), 264-257 (0226723), 264-377 (0226729), 264-380 (0226726) , 264-418(0226709) 

## & 264-511(0226706) 

## From:

To: 

## Mark J. 

## Perry, Biologist Precautionary Review Section Registration Support Branch Registration Division (750SW) Wanda Ruffin Daughtry Special Review and Reregistration Division (7S08W) Applicant:Rhone Poulenc Ag Company P.O. Box 12014 

## 2 T.W. Alexander Drive Research Triangle Park, NC 27709

BACKGROUND 

## Rhone Poulenc Ag Company has submitted or cited acute data for several products (listed above) in response to the Ethephon RED. The products are addressed in accordance with the acute toxicity batching strategy included in the RED document. Ethephon is a plant growth regulator used to promote fruit ripening, flower induction and other similar responses from treated plants.
RECOMMENDATIONS Batch 1: EPA Reg. 

## Nos. 264-263 

## & 264-543 81-1, Category 

### IV (MRIO 439205-01*) 81-2, Category 

### III (MRIO 439205-03*) 

### 81-3: 

## Category IV 

## (Based on Technical) 81-4, Category 

### III (MRIO 418674-01) 81-5, Category 

### IV (MRIO 418015-01) 

### 81-6: 

## Non-sensitizer (Based on Technical) 

## * MRID 439205-01 and 439205-03 received an abbreviated review to the results of the acute oral and dermal testing on technical Ethephon. due



# 64

# •

• Batch 2, EPA Reg. Nos. 264-267, 264-292 

## & 264-376 81-1, Category III (MRID 439205-02*) 81-2, Category III (MRID'439205-03*) 

## 81-3: Category IV (based on Technical) 81-4, 

## The eye irritation study cited to support this requirement cannot be located (MRID 00070086). As a result, 81-4 is a data gap for· the batch 2 products listed above. The registrant may 

## choose to submit a copy of the cited document for review, or cite alternative eye irritation data to support reregistration of the products in this batch. 81-5, Category III (MRID 00251542) 

## 81-6: Non-sensitizer (Based on Technical) 

# * MRIDs 439205-02 and 439205-03 received abbreviated reviews due to the results of the acute oral and dermal testing on technical Ethephon.**",_,,_~**

### __**~'_~~"__** 

### .



# -------**--~''''** 

### Batch 3, EPA Reg. Nos. 264-257,

# 264-37~264-38~ 81-1: Category III (Based on

# TeChn~ 81-2: Category III (Based on Technical) 81-3: Category IV (Based on Technical) 81-4, Category I (MRID 00248658) 81-5, Category II (MRID 00251542 

## & 00248658) 

## 81-6: Non-sensitizer (Based on Technical) Batch 4:' EPA Reg. Nos. 264-418 81-1: Category III (Based on Technical) 81-2: Category III (Based on Technical) 81-3: Category IV (Based on Technical) 81-4: Category I (MRID 00248658) Due to the category I eye 

## irritation observed in a 39.9% batch 3 product (MRID 00248658), PRS has decided to use this study to support the subject (55.4%) product. 81-5, Category I (MRID 428727-01) 

## 81-.6: Non-sensitizer (Based on Technical) Batch 5, EPA Reg. Nos. 264-511 

## 81-1: Category III (Based on Technical) 81-2: Category III (Based on Technical) 81-3: Category IV (Based on Technical) 81-4: Category I Requirement waived due to expected severity of eye 

# 65**-:----~--------------c___------------------------**



# • irritation testing results. 81-5: Category I (MRID 00029513) 

## 81-6: Non-sensitizer (Based on Technical)


## LABELING Batch 1: 

## 1. The recommended 

## signal word 

## is caution. 

## 2. The recommended precautionary statements are as follows: Harmful 

## if absorbed through 

## skin. Causes moderate-eye irritation. Avoid contact with eyes, skin or clothing. Wear 

## long-sleeved shirt and long pants, socks and shoes and chemical resistant gloves (such as Nitrile, Butyl, Neoprene, and/or Barrier Laminate). Wash thoroughly with soap and water after handling. 3. The recommended statements' of practical treatment are as 

## follows: IF ON SKIN: Wash with plenty of soap and water', Get medical 

## attention. IF IN EYES: 

## physician 

## if
Batch 2 Flush eyes with plenty of water. irritation persists. Call a**~** 

## 1. The recommended signal word is caution. 2. The recommended precautionary statements are as follows: Harmful if swallowed or absorbed through skin. Avoid contact with eyes, skin or clothing. Wear long-sleeved**shi~t** 

## and long pants, socks and shoes and chemical resistant gloves (such as Nitrile, Butyl, Neoprene, and/or Barrier Laminate). Wash thoroughly with soap and water after handling. 3. The recommended statements of practical treatment are as follows: IF SWALLOWED: Call a physician or Poison Control Center. Drink 1 or 2 glasses of water and induce vomiting by touching back of throat with finger. If person is unconscious, do not give anything by mouth and do not induce vomiting. IF ON SKIN: Wash with plenty of soap and water. Get medical attention. 

# 66

# , I'**----~ /~**  '\

## (~ Batch 3 '

# ~:ducts in this batch meet the criteria for

# res~ricted use classification due to eye irritation. The PM Team should 

## decide if restricted use classification is necessary or if alternative labeling will allay the requirement for restricted use classification. 2. The recommended signal word is danger/peligro. 3. The recommended precautionary statements are as follows: 

# • Corrosive. Causes irreversible eye damage and skin irritation. Harmful 

## if swallowed or absorbed through skin. Do not get in eyes, on skin or on clothing. Avoid contact with skin. Wear coveralls worn over short-sleeved shirt and short pants, socks and chemical resistant footwear, goggles or face shield and chemical resistant gloves (such as Nitrile, Butyl, Neoprene, and/or Barrier Laminate). Wash thoroughly with soap and water after handling. Remove contaminated clothing and wash clothing before reuse. 4. 

## The recommended statements of practical treatment are as follows: IF SWALLOWED: Call a 

## physician or Poison Control Center. Do not induce vomiting. Drink promptly a large quantity of milk, egg whites, gelatin solution, or if these are not available, drink large quantities or water. Avoid alcohol. IF ON SKIN: Wash with plenty of soap and water. Get medical attention. IF IN BYES: Hold eyelids open and flush with steady, gentle stream of water for 15 

## minutes. Get medical attention. 5. 

## NOTE TO 

## PHYSICIAN: Probable mucosal damage may contraindicate the use of gastric lavage. Batch 4 1. The products in this batch meet the criteria for restricted use classification due to eye irritation. The PM Team should decide if restricted use classification is necessary or if alternative labeling will allay the requirement for restricted use classification. 2. The recommended signal word is danger/peligro.



# 67

# • 3. The recommended precautionary statements are as follows: Corrosive. Causes irreversible eye damage or skin burns. Harmful if swallowed or absorbed through skin. Do not get in eyes, on skin or on clothing. Wear coveralls oVer long-sleeved shirt and long pants, socks and chemical resistant footwear, goggles' or face shield- and chemical resistant gloves (such as Nitrile, Butyl, Neoprene, "and/or Barrier Laminate). ·Wash thoroughly with soap and water after handling. Remove contaminated clothing and wash clothing before reuse. 4. The recommended statements of practical treatment are as follows: IF SWALLOWED: Call a physician or Poison Control Center. Do not induce vomiting. Drink promptly a large quantity of milk, egg whites, gelatin solution, or if these are not available, drink large quantities of water. Avoid alcohol. IF ON SKIN: Wash with plenty of soap and water. Get medical attention. IF IN EYES: Hold eyelids open and flush with steady, gentle stream of water for 15 minutes. Get medical attention. 5. NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate the use· of gastric lavage.
Batch 5 1. The recommended signal word is danger. 2. The recommended precautionary statements are as follows": Corrosive. Causes irreversible eye damage or skin burns. Harmful if swallowed or absorbed through skin. Do not get in eyes, on skin or on clothing. Wear goggles or face shield. Wear protective clothing and rubber gloves. Wash thoroughly with soap and water after handling. Remove contaminated clothing and wash clothing before reuse. 3. The recommended statements of practical treatment are as follows: IF SWALLOWED: Call a physician or Poison Control Center. Do not induce vomiting. Drink promptly a large quantity of milk, egg whites, gelatin solution, or if these are not available, drink large quantities of water. Avoid alcohol. IF ON SKIN: Wash with plenty of soap and water. Get medical attention. IF IN EYES: Hold eyelids open and flush with steady, gentle 

# 68

### ,

# ~.



# •

• •

stream of water for 15 

## minutes. Get medical attention. 4. NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate 

## the use of gastric lavage

.



# 69**--~~~~--------~~-------------------**



## DP BARCODE: D226726 CASE: 003340 DATA PACKAGE RECORD DATE: 05/31/96 SUBMISSION: 5499336 BEAN SHEET page 1 of 1 

# * * * CASE/SUBMISSION INFORMATION 

# * * * CASE TYPE: REGISTRATION ACTION: 674 8 

## lIN'l'Il liESP-PROD SPC DATA RANKING : CHEMICAIS : 

# o POINTS () 099801 Ethephon 39.9000% IDt: 000264-00380 PREP PLANT REGULATOR 

## FOR COTTON COMPANY: 000264 lUIONE-POULENC AG COMPANY PRODUCT MANAGER: 25 ROBERT TAYLOR 703-305-6800 ROOM: CM2 241 

## PM TEAM REVIEWER: WANDA RUFFIN DAUGHTRY 703-308-8171 ROOM: CSl 1K4 RECEIVED DATE: 01/23/96 DUE OUT DATE: 07/21/96 

# • • * DATA PACKAGE INFORMATION 

# * * * DP BARCODE: 226726 EXPEDITE: N DATE SENT: 05/31/96 DATE RET.: 

## / CHEMICAL: 099801 Ethephon
• TYPE: 001 Submission Related Data Package CSF: Y 

## LABEL: Y 

## ASSIGNED TO DATE IN DATE OUT

DIV:RD // // ADMIN DUE DATE: NEGOT DATE: 08/29/96 

## / / BRAN: 

## RSB / / / / SECT: PRS / / / / PROJ DATE: 

## / 

## / REVR: // // CONTR: / / / / 

# * • * DATA REVIEW INSTRUCTIONS 

# * * 

# * Please complete 8 month reregistration review of data for product under Ethephon RED (0382). Thanka 81-1 and 81-2 citing KRIDs 00116670 and 00248658 81-3 and 81-6 citing KRIDs 00138194 and 00252901 81-4 citing MRIDs 00116670 and 00248658 81-5 citing KRID 000159531

_) PLEASE RETUlUl 

## TO W. DAUGHTRY, CS1, 3RD FLOOR, SRRD-7508W 

# • * * DATA PACKAGE EVALUATION 

# * * 

# * No evaluation is written for this data package



# * * 

# * ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION • 

# * * DP BC 226724 BRANCH/SECTION RSB/PCRS DATE OUT 05/31/96 DUE BACK 08/29/96 INS Y 

## CSF Y



# 70 /

LABEL YFEB-.29-19% 17:22 FR0l1 OPP/SRRD/IO 

### TO



### -- 

## - UnitGd States Envtronmentet Protection Agency 

### Form Approved 

### W.uhin01On. DC 20460 OM8 No. 2070- 

### 0107, 

### CERTIFICATION WITH RESPiCTTO 2070-0057

.


# . DATA COMPENSATION REQUIREMENTS Appro,,·.1 EXiJiru.s

. 

### 3-31-98**PubU~** rltporting burden fot**~hle** oolleotion ofIntorTnDtlon is Mtimatodto avOnlgo 16minut\t4 par roopcnco. including timo tot r(Mowing trlsttuctions, searching exiSting data sourc... oath"'g and maintaining the data needed, and cOmpjtrling- and reviewing the l;oUection Of informatiOn. Send Commeotl rtQ8railO ttle burdon 'OStinite or any other

## atpeci ofthis collection of infonnatloo. includinO &UOgeations for reducing this bUtdan to. 

### Ch

... Imorma1.ion Polley Branch. PM-233. U.S. EnvironrMOtll Protection Agency, 401 M St., S.W., Wnhnuton. DC 20460;and to the Office of Mlnagemam: anti Budget, Paperwork Reduction Project f207(}-010(H,Wuhington, DC 20603.
PI

....

### fill in blanb balow.
C......,I"YN

........ C""""'•...,

## Numo., Rhone-Pou1 enc Ag Company 

### 264

. , 

## , PrMuetN_ EPA Rq.No. 

# • PREpHi brand Ethephon 

### Pl 

## ant Regulator' 

### for Cotton 

### 380 IC","" that, 1- For eaCh rtt.lI:iy cited in SUpport ofregistration or reregistTe1iion underthe Federallnseetioide, Fungicide end Rodenticide Act fFIFAAI that itan exclusive use I'tUdy, Iam theanginal 

### data submitter, or Ihave obtained the written pmmiasion ofthe Original data submitterto cite

### ttatS\lIdy. 

### 2. That fot each study cited In supportofragistration or hltegiablation under FlFRA that" NOT an excluslv1! use study, I am theoriginal datasubmitter, or Ihave obtained thewritt..-. permiasion ofthe original data submitter, or Ihavenotified in writing thecompanyfles) that.submitted 

### data Ihavecited and hove otferedto: (a} Pay compensation for thosedata in accoraaneo Wrth SectIons31cU1)lFI and 3fcIl2}ID) 01 FIFRA; ana (bl commencenegOtiatiOn todBtemWla which dataare subjectto thecompensatiOn requirement ofFIFRA and theamountOf compensation due, 

### itany. The companies Ihave notftied are. {Check omtl

[ 1

### The companies who have 8\lbmlttedthestudiesfitrttd on the back ofthia form or attachedsheets, orindicated onthe attached -Requirements StatU.and**Rl!9~rat'lts'** RasponHForm," 

### 3_ That" Ihavepreviou.1y compUed with seetlon 31c)!1)lFI of FIFRA fortheIrt\fdles I hancited 

### In support ot tegistration or reregistration under FIFRA

.

. . -..

# _ ..-

## .

.... M. 

# f:!7 

# V Date

## 3~9J(;- 

## t

# /~~/**JI;~J[.g** Name lind TIti. 11'1

.....Typ. or !"tintl

Gail POI'le11 , Registration Manager 

### • 

### , 

## " QENEAAL OFFER TO PAY. I hontbyoffm' and agree to pay oomponutionto othorpanlon$, with rtlClilrd to tho registration orreregistrltion of my products, to the extentrequirad by F1FRA section 3lel(l)1F! and 3Ic)(2ItDI.
SlgllllIWO:O

# ~,f'

# f~dL**O~.**



# .3//7/7(,-.

..**{~~** NIrM**~** TItio \1'1_. Type ort'l'mU

Gail Powell, Registration**f~anager**


## - - "I'A ....,.. 

# " 

# ,

71

# •

) EPA File S""",,'/Rea. No.**_-,2~6!:j4c:-~38"\lQ!::-:--,-_** 

### nate of acolieat.lal

____ _**"n~ E"tl'~t'I<.<** .....

## ~ of Prt:duet: 

## _.!:P.!lR

.. EPl:.t;:.m::..-

......

## ~ft:.1J.jaunut;..J1Re~gwtLJ!J"'a"'tlloc.c..;ft.co"rc...!,;Coo.tt;tt.<o""'-______ _ ADclicant"s Name 

### and Aclc.1ress RhOne-Ppplen, 49 

### Gompan,y 

### P. O. Box 12014
Research Icj

### aog] e Park**~I** 

### C 27709



### 1. This 8C'Pllcat.ion is**~** 

### by 

### all data**1NtDit.~** 

### or cited 

### in the 

### appUea.t.icn. In 

### addit.ion, 

### it: eiee-all t:::Ipeions are irxSicat.ed, this applic:adcn is**~rud** 

### by 

### all datA 

### in the 

### Jqctncy's 

### fil_ that 

### eonc:em t.he Pt'CPGIrtlU 

### or effectS of this 

### tmXIuc1: or 

## ot any oeMr grcduc:t:. dlat 

### is ident:lc:a.l or auDatantially similar. and 

### that. 

### is CInIt 

### of the types 

### of data that 

### would be 

### raquirac1 

### to be 1lUtlDit.tec1 

### it: this applicat.icn ac:u;tlt t:M 

### init.ial 1"8Qutnt.ion ot: 

## a.**p~** 

### of 

### identical or similar CUllY 

### atUm 

# ana intended 

### WIH urdar 

### the dat.a 

### requirlDlna in 

### effect. en 't.hII 

### date of 

## awzwal of this 

### a;IIPlicadon. 2. I 

### certify that. 

### for eech 

### st:u::Sy cited in supoott 

### of this 

### applieat.ion for registn.tion tttac is an eXCllJlilVWl use s'tUdy, I have obtained 

### t.lote written plu:raiuicn of the 

### ori;inAl data s\.'l:mit.ur 

### to cit.. that. 

### Stu::tva 3. r certify**t.hat.~** 

### for each study cited 

### In S1.JCXIC)n 

### of this 

### a;o.licacion for regUtration 

### that. 

### is**~** 

### an nelusiVlt use atu:!y: I have 

### obtained**t.~.** 

### woritten pemissicn 

### of the 

### cr:iQinal data 

### sutrait.t.er too 

### cit.. 

### that. s:u::ty;**~** 

### t have 

### not,ified in wridn;r the**~.s** 

### who turve 

### ll'Ul:nit.ted 

### r!at:.a I 

### have cit.ed to sucoor1: 

### this 

### acpUc:auon ancl 

### havtt 

### oUend to:- 

### (al pay**~nsat.ion** 

### for thoH 

### data 

### In

# .=- vith _Ial 3(c)(1)(D) arrl 

### 3(c)(2)(0) 

## at tile 

# "-ral I_lcide. IWglcicSe arrl
__ 

### icicle Act. 

### arrl 

### (bl OJ

...."'" negoeiaticn:l 

### to detemine which data 

### an SUbject 

### to the 

## cuew
....t.icn 

### requitalWflt. of !'1'FRA and 

### the 

### 1IIIOUnt. ard 

### tea. of cuupanaat.1cn**Qua~** 

### if any. 'Iba Cl2llpraftiea 

### t have ncxified arel (0Wck 

### cnel f\.(l 

### All e:zapanies 

### listed en the 

### Pesticide Data Sutm1t.t.ers L1st. tor all aetive in;ndienu c:onuined in my pra:fuct. 

### (Cite-4ll1'DKhod or cit..e-llU opt..1cn 

### un:ktr selecc.iw Mtthod). (Also 

### sian the General Offer t.o Pay Statmane belc:N.) {>4**nx..~**

## .._ haw 

### _tted the 

### at:u<!l

.. 

### vlUch I

_ 

### ciuct (Seleccive 

### m.ChI:::d)
SlQnature

# "'G",~;.,c;;;;:ow~e~f~:d/~,----- .... • • 

## Title**.R~e~gUijslttra~tliuo~n~M~anw.~gue~r~**

## ____**~** 

## ••••

ext.ent. 

### AqUind**~** 

### DI.. I

# z../zq

# iT,
, 

# - 

# . . •••••• •



# ... •••• S!ana"""**_L.~:L~~:W.":'.** 

## __ Title 

# &,1>&$.-..jlfwtj'-'V: '::-

(.11 19851 

### •••• • 

## ••

•• 

## • 

# 72

# . 

# "'" 

# . 

# ..,,"',**.f.~**

# .**Fo~** OMS N,. 2070.0060.


# .0"".'. United StatU, 

# B Registration opp Identifial Numb., 

# oEPA Environmental Protection Agency Amendment 

# 251317 Wll4hillQton, DC 20460 

## Other 

# .



# . Application for Pesticide

- Section I 1. CompanylProduct Number 2. EPA Product Monage, 3, Propoeod Classification 

### 264-380 

## Theresa Stowe 

# I1J NollO 

# D RD81licted 

### 4,

### comPlnVlProtu~~~E~ 

### PM'



## PREptm "dJ" i

## ~;~:iIJl.TnD 

## FnR #22 5. Namll and Addr

... of Applicant (lncludo ZIP Coda} 

### 6. Expedited Review. In accordance with

### FtFRA Section 3(c)(3) 

## Rhone-Poulenc Ag Company lb)(i), my product Is similar or Idenilcalln composition and labeling 

## P,O. Box 12014 to: 

## Research Triangle Park. NC 27709 EPA Reg. No. 

# D CIm:k. iftills/$.ntlwtJdrhou 

### Product Name 

## Section

- II

## ~**Am'''''~"t·** .,.",,"

# ,.,w. 

# 0 Fine! printed label. in ,.upons, to Agency 'ettordated R•• ubminionIn rlapornro 10 Agencyleue,dDlsd 

# 0 -MeToo· AppUoalfon. 

# D Notificlltion

### ~ Explain bolow. 

# 0 Olh"

- ExplDin holow. 

## Explanation: Us, additional psoai.) If Moenery. (For sictlon I end S.cllon II.)



## Revisions to label as required by 

## Ethephon RED. Aprifl 28. 1995. 

## Move 2 paragraphs from "General Information" section to "Equipment Cleaning" section. Add "Use 

## Limitations" section. Added "brand Ethephon u 

## to product name.

Section

- III 1. Mate".ThkProductWiD 

## a. Packagod In: Child·ResistantPsokeglng Unit Paokeging Wate'Soluble Packagilll1 2. Typo of Conte/nor 

# •8::" - Yn 

### r- Yes

# ~~t•

# ~ N, 

# k:: N, ptutio Gle

.. 

### • CertiflCIltion 

### must If "Yee" No. per If**"Yes~** No. po, Peper Unlt Packaging wgt. container Peok.ge wgt oonlaino' Other ISp.olly) 

### btl

### submltted 

# , 3. Location of Not Conlentl: Information 4. Sizels) Relail Container**5~tiOn** of Label OiroctioM 

# GJ Lob_ 

# O Containor .? 

### '.5.0.30. 110 

### Q.11on· 

# 4 Onlabol On labeling acoompenyingproduot B. Manner in Which Labol is Affbcod to Product

# ~ Uthognwh 

# Il.I Other**glasti~ppe~** 

## glued to container PIlP!r.Uod Ste

.ed 

## ins lab.l Seotlon

- IV 1, COnlect Point (Compt.,.itlfM dir.ctlyb,/owforidtmtilic.tion .f Indivldufll to b. tonracrod, if nO'cO$$my, to proCfIU**thIs~"** Title

### ~ Namo Telephone**No.~** , 0 Area Code) 

## Gail 

## Powell Registration Manager 919/549- 

## Wo. • Certification 

## •••••• B. O.te ApPffcation 

## • • • •

# "'''~ I certify thet the etluernents I hew made onthis form end

## au ettachmonts therelo aro true. accurate and oOl'lflW

... Iacknowledge tru.t anyknowingly fGlso or mi.loading statomont may ba puni.hab!a byfino or imp"'onmant or. : 

## • 

# .. JStal"pedl both undar IIPfIlicabht law. " 

## • • • 

# •• •• 2.**Sigl'lOture~** . 3. Titlo 

## • 

## •

# (J~ ••••• • 

## Registration Manager • 

## •• • • • 

## /' 

## •••• 4. Typed NAIM 5.0ato 

## •••• • • •



# .. • Gail 

## Powell 12/15/95 

## 7':1. EPA Form 8670-1 (ft.v. 8 941 Previou. editioM era oiaolete. 

## . WhIM •EPA PhCOpy lorlglnal) 

# - Yllow Applicant Copy

### PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS



## , PAPERwDRK 

### REDUCTION ACT 

### NOTICE; 'PtJblic reporting burdan for thil coUocnon of informolion is utlm1)too to O\l(Hllll" 0.85 heur

# pw nlllpOnGO, Including tifnll for ra\'illwlng iustructionll. natchlng oxlsting dOll1 sources, gathering and muint,ulning thl!; data nellded. and ccmphning and '" H'\liowing tho collection of In/ormlltlon. Send C<mml1llltl fll9Atcllng the burdan ostimate or any other allpGct of lhill' collection ofIn/ormation, inclUding ,uog8arlonll for reducing**tI~8** burdon, to Chillf, lnf6rmotlon Policy ehmen, /21361. U.S. Environmantnl Protection Agency, 401 M Stroot, SW, • WOllhington, be 20460. INSTRUCTIONS; ThIll" form io to bo uaad for BlJ eppllcalion9 for now roglstration, and uso rereglstration. amendment, fOliUbmillllion, to applicatlonll for not/flooUon,_ final printod labollng,**ror~gilltrotion,** otc. In orum toprocess an npplicotion for a now registration submitted on this form, tM following materiel mustaaoompanytho applicstion: 1. Certlfioatlon with Ra4p8ct to CItation of Oato IEPA Form 8570·291. Ilf not oxempted by 40 CFR 152.81**~bI14)J:** 2. Confidential Statomont of FormuialEPA Fotm 8510·41: 3. Formulator', EXomption StetOMant (EPA Form 8510·271; 4.**Fi~** oopiee ofdraft IlIbeling; 5. ThrOCl coplu of any data submitted; 6. Authorb:ation letterwhore oppJicllblo; 7. Motnco. whero appllcablo. Submlsalon of Labellno· Lllbaling should fir61 bo IiUtsmltttd In the form ofdrillt Illbel' wilh all application. for now ragistration. Such draftllibels may ba In tM form of typed looe! text on 8.5 x 11 inch P3pIU for submilllion or a mockup of the proposed**lob~.** If proparad for moekup, it shouldbe constructed in a way os to facilitQto 5tOragO in an 0.5 It: 11 Inch /lilt, Mockup Iltbelt signiflcantly smollar than 0.5 x 11 Incho•• h9uld bo mountltd on'8.5 x 11 inch p.por for IIubmiulon. '" • SubmIssion of**D.~·** Data submittad in IiUpport 01 tlli. application muol be .ubmittod in occordlln<:o with PR Notice 86-5. 

### SPECIFIC INSTRUCTIONS; Pluse road tho in$lructions listed below boloro completing tiliG .pplicotion. Firet dotom\ine}M type of fogistration action, listed in Block A, for y.'hich you ora lIubrnitting this application. For applications Gubmittlld In cormection with New Ragistrotion actions, Sections I, lll, and IV mUDt be ccmp/etod bytho applicant. For spplicotionll submitted In connection with omanded rar8giDtration fictions, reeubmhrslon., notifications, rerogistrations. etc., Sections I, II, tmd IV mu.t be completed bytho applicant, 810ck A • Chock the appr6prlate lIetion for which you aro SUbmIttIng this f0tl'!". 

### SECTION I·Thi. section muSt DO comp/OIod, tiS app/icabltf, for all regi,mauon eotion,. I. Compenyll'roduetNumber -Insert your CompanyNumber, if OlIO hes been ossigned byEPA. This number may hava b8lln allll:ignad to you ell a bllsic reo/slront. iI dilltributor, or os an IUltabllshm"nt. tf your proouct**I~** registared, inurt the Product Number. 2. EPA ProductManager· If known, fill in tM Mmll and PM nUmber,of th(l EPA Product M(lnogllr. 3. Proposed Claoslliootion**~** Spacl/ytho proposed olonification of this product. 4. ProductName· Entortha eol1'TP1ate product name of thi,l pullcide'olll! will appear on the labal, Tha name fTltjU ba apeoific tothisprodUct onlV. Duplication ofnllffi\ts Is notpllnniUed**~ong** products of tho 'l101,e COl)1pllny_ 00 not includa enybrand nllll\U or IXilnflllny IiftO dollignationc. 5. NOIM ,end Add

... " ofApplicant

- nle name of the frrm orpe($On and /lddrlul$ chown in your application i. th. pefson or firm to whom the rogisttlltion

.....UI be issued. Ifyou**~e** aoting in behslf oillnothor party, you mu&! submit ouilioritlltion from that partyto act for thamIn rogi$tration mstto,.. An applioant not re61ding in tho United StataD mu.t have an authorlled agent reruding In tho Unitltd StatlHI to actfor tham in eU**r~stttltion** mailers. Tho name

## and oompleto mailing addressof**~uch** an agentmust accOffipilny this applicetion. • 6. EXpadlted Remw· FlFRA section 3 (c) 3 lSI provldllli for oxpedited roview of applicatlO!1I1 1M reglstrlltlon, or amsndmel1l$ to existing roglltrati that are similor or identical to other pesticids products thatare currently**re\lh~tered** with tho- EPA, In order for your application to be ollglble for expedited roview, you must provida UII with th(l EPA**Rogi,~trlltion** Numb,r and product namo'of the product you bellevo i. similer to or fdenticlllto your product. Tho product mu4t ba .imilaror Identieal in bothformulation and labllled USOll. SECT10N II •TN. allctlon must**b~** completod for 8U applications submluad to emand tho raglirtr8tion only of 8 eurrently rogisterlld product IAmandmentl, for a resubmisolon In tOll.l1on"a to 8n Atl"'ncy lottur, for notlflcellofUI to th. Agoncy, for tho .\.Ibmltoion of final prlntlld leboling. for rafogi.trotion and for eny other ,ctionthet perteins to II !!pgnifin EPA,'rJ1Qi"'torad prpduct. Thls "ctionIs!l2!

### 12!!.!! !,l.ad for. new eppllcetlen for rllgistr.llan. 1. SubJeot of IIUbml=lIi!)!1 •Chol:lk tha opplic6We block and provide lhll Agency loltllr dete If appropriato. Providll it brief oxplllnlltlon of the purposols) for the lIubmis$ion, suehas**~th!l** addition of II sito, peot or orop**l,peclfYI·~** "amend theConfidontial Statement of Formula by

...·; "roregistretion**illUbmis1lion~;** "oonorelleblli r,vision ofuse direotions." Attoch b .oparote page if additional spaoe isneoded• 

# .... , 

### SECTION**lII"1i'.~T$ng** and Contniner Informlltionl'Thill Section must ba completed for aU appliClltionD llubmiUod in cOMaction with n,w raQiatretion cf**~abla** amandments. 1. TYf}O ofPe&'"4lIh\:- Chock tlltl nppropriote block If your product will bu packngod in tho indicatedpackugiug typos. Indicete the

# sl,. of theln4lvl"'tlli,packets and number per retail eontalnor. 2. Typo ofRettlfCorleinor '3nd'katl type of containerin which product will bo marketed. 3. Location of.a.tCc.rtonte: ;,**~~cl~o** the location ofthe not content, informetion for your product. 4, Slze(.1 

## m n.t.lCootamw.-**'~mfy** tho netcontonts of all r,tlill contllintlrs fOf your product. 5. LocetiOfl of",." triIl'H:UCfH; !rndlcoto tho locotion ofthe U$U dirsclions for your product. 

### S, MaMaf in**~fala1** 

### r.-'1Il1M4t"tt product

- Indicated ttle m$thod prodUct lobelis nttachad to retail eontainar

. 

# • ••••• SECTION IY,IUgt4tPmn!)

- Thle S"ot/on ml.n.t 

### be compluted for cllapPUcQtloM for Registrlltion actions. i."., new products registration. relR.tbml"lon, "ntdlM," reregi.tration, ete
. 

### •••• 1-5.**Sl)/f·oxpIs,,~~**•• 6. EPA Usa cSn!y_ •



# ,..,.

# , '.m> '" OMSN•. 

# &EPA Unltod States 

### f- 

## Roglstratlon 0"Identifier Number 

## Environmental Protection Agency

# ~ Amendment 

# 251317 i**Wo~"llngton.** DC 20460 

## Other 

# . 

# , I 

## for I' 

### , I 1. Company/Product Numb., 2. EPA Produot Manager 3. Proposed CI

... Uicatlon 

### 264-380 

## Stowe 

# E1None 

# D Ra.trictod 

### \1\(1'00 

### <IN 

### '''1'' PM'



# . OR FilR CO TWN 

## ¥22 5. Namo ancLAddte

.. of Applioant /lnclude ZIP Codo} 6. Expedited Review. In accordance with FIFRA Section 31e1l3) ,{H011C**~** Priu1E'r)( 

# "9 Company Ibllil, my product is similar or IdentiCal in composition and labeling ;) ", 

### SOX 

### 12014 to,

, •tl,

### :~est?nl.1 Tdangle Pal'l( , 

# w; 21709 

# , EPA Reg. No.

• newaddrllSS

# ~**"A~ndm,"'** - Exp'",.

# '''OW. 

# 0 Final printed lebllls In rO'Pon

..to Allonoyletterdotod Resubmillion 1n raspon•• to Ageney lotter dated 

# 0**~M.** Too· Appltcltion. 

# 0 Notification**~** Expleln below. 

# 0 Other· explain balow• Explanation: UfO addldonal pagel.llf Mellllary. IFor .action land Sactlon 11.1 

# .

Rev isj 

### ons to 1 aD;:': i h$ i'0QU 

### ited hi E

### t!lephon , Iq.){ifi 2(1, 

### J**~** 1<:(1'1(: 

### 2 

### pafftgtofjf1 

### s 

### f ,'OiL 

### I 

### 1 

### nformat

### ion" 

## section 

## to "Equipment Cleaning" 

## section. Md "Usc' Llmftatlo[1s" 5<:;: Ti 'Ai Add2d "LH'Jnd 

### Et?l(,phon,. 

## to P(0GUCt flalf!? < 

# ,:ui
! ,. 

# .. Child·ReaiDlant Packaging**~r** Soluble Packaging 

# .., 

# .By

... r- 

# y ..

- Yes**...,~** it No 

# t;: N. :;:: N. 

# ::r PllOtic Glue 

# I**~:y!,.** No_ P" It**~Yo.~** No. par 

# - Paper 

### • CtN1Jfication 

## must 

# - blJ

### submlttlJd w",. Plckege wgt oontalnor 

# - Other 

# , 

# "iil Lob: 

# 0' No< I 

# o Container 

# 14. 5i

..,.jl 

# .p=j**o~o~**.. 

## .2.".S.Q.3U !10,H;· 

### • On oooompanying product 6. Manner in Which lebella Afflxad to Product

# ~ l!1 Other l>1,jSUc

### !i'~apqF!' ';!!Ii"'d ]. 

### ",,.nl ;,,1;>' 

### contains 1,bel 

### ,-IV

,.Co.""**P~.'** 

# ,

# ""'.

N"'11.11 

### i 

### ' " Titlo 

### ik'jlst.rfd.lofj (,1, 

# ;1:',**I~~** rowej ; 

### Certification

.

# ~ ,•.D,,, 

### I, """ythat ""

...**"~.,,** ,**h~.** mo" o.fm. I.m> 'M " 

# ""',hm••"f",

.. f

....IN

.......... ond " I acknowledge**~'~_,** flllaa or millloadlno atatlmontmaybo " both undor 

# - 2.

## 5"M,",'~< . 3. Tltlo 

## / 

# - •

I**~.t** :>.'(j\ ,:>t:'-Jt

### lon r\'\Hi'i:i<:;( 

# ;,.:. 14. Typod NIII'nII 

# Is. D,

.. 

# .::;-,

.;; i '?;Yf'<C j i • 

## : ';; ,i:' 

## 71::. ,8570-' 

### IRoY.'

### ~.t. 

# .- Cop,

### PAPERWORK REDUCTION ACT NOTICE !Il1d INSTRUCTIONS
PAPERWORK REDUCTION ACT NOT(CE; Public reportIng burdfln for this collection ofInformation I.- olitimatlXi to 8W1'rlllg.o 0.a5 hour por rosponsa, Including limo for reviallifng [nlltructions, searching IIxh;ting dnta $oo(oea, gathering and maintaining tho data needed, and complClting and • reviewing tho oollection of Informotion. Sond COmmllnlS ragluding thehurdon oelimato orany other aspect of thIs tollaoilon ofInformation, Including**~** lIIuooostionl for reducing this burdon. to Chiof, Information**Po~cy** Stench, (2136). U,S. Environfnentlll Protoctian AOoncy, 401 M Str.ot, SW, Washington, DC 20400.
INSTRUCTIONSi This form 10 tobo used for ell applications for n<lW (oghmotion. ond us. rerogisUation, /Ifl'loru.imont, tellubmisaioll. to applications for notificationl, final printod hlboling, rcregistretlon, ttc. In erdtrto proco,. tin IIppliclltion for a new rtlgilltration .ubmlnod on this ferm, tM following matariel mullt aocompany tha applicstion: 1. Cartifloatlon With Ae$pact to Citation of Data IEPA Form 8570-29). (If not axampted by40 CFR 152,81 Ib) 141): 2. Confldentiel Statomont of FormulalEPA Form S570-41; 3. Formulator'. Exomption Statoment tEPA Form 8570-271; 4. Five ooplea of draftlabeling: 5. Th,.e eopia. of any date .ubmined: 6. Authorization lener whore apprlCeble; 7. Metrica. wMrd dppllcohle. $ubml5.lon ofLabeling

- Laballng should 'Ii,.tbo submitted in the form ofdraftlabala with oll appIlcatlontl for new ragiatration. Suchdraftlabals maybo in tho form of typod labo! text on 8.5x 11 Inch paperfor submission or a mockup ofthaproposod labal. Ifpreparod for mockup, It should ba COnfttuctad In e wsy ..to facililete storage In an 8.5 X1I inchfilth Mockup lab01. significantly smallerthun 8.5

### x 11 Inches .hould be mounted o'_S x 11 Inch paporfor .ubmhf8ion. Submls(i1on of Ootll- Data subminod in .upportof this application mus-t ba $ubmitted in accordance with PR Notioe 86·5. 

### SPECIFIC INSTRUCTIONS; Plaasa read tha instructionslillted below befOUl comploting this application. fir,t datermino tha type of ragl$tratlon action. listed In Block A, for which you lUll submittingthi$ applicotion. For opplicatlonllllubmittod In connection wIth Naw Registration actioM, Sections I, III, and IVmuatbe completed bytho applicant. For applications aubmlned in connsction with amanded rareglstration II(:tlon$, ruubmluions, notifications, reregistrations, atc., Sactlons I, II, and IVmustbe completed by tho applicant. Block A· Chook tha appropriata action for which you ara wbmitting this form. 

### SECTION (. This saction must ba complatad, as applicabla. for 

### &/1 ragi$lration octionl. 1. CompanylProduct Number -Insortyour Company Numbor, if ona has boon auignad byEPA. Thi$ numbor may haveboan oll$igned to you as a basic registrant, a distributor. or os en utablishmClnt. If your prodUct ia reglstarad, Incart tha Product Numbor. 2. EPA ProductManager

- )fknown,

### fin In tho nomo and PM numbar oftha EPA Product Menager. 3. PropOllod C1

...lffcfltion

- Spacifytho propooed olossificotion of thisproduot. i 4. ProductName· Enter the complote prodUct neme ofthis posticide os it will appallr on tho lobel. Tho neme mull bo $peoific tothisproduct only. 

# I Oupllcetion of n&mes;s not pormittlld among productsof the sama company. 00 notincluda any brand nmno or companylina dsaignationll. S. Name Gnd Addr

...ofAppllcnmt·The name oftho firm or fUilr!l:on ond JlddruslI shown In yD\lr application i, thoparson 0(firm to Whom the rllgistration will ba iswad. Ifyou ere octing in behalfof anotharporty, you must submit IlUthori18Uon from that partyto act for them in r(lgiotr

...**~'l** mattere. An applicant not raliding in tho United Stateo must heve en authorized egent rasiding In the Unltad Statal to act for them In lJIl f, ) rogistretion monorl. Tha nama and comptate momng address of suchGn agent must acoompany this oppUcation. • 6. Expedited Rovlow

- FIFRA soction3 Icl 3 tS) prov\dosfor oxpedited revlow of appllcatio!UJ; for ragistrlltion, or 4I'nondmenU to axistlng roglstra that are timllar orklenticlJl to otllor potticidoproducts that Ira currontlyragl$terlld with tho EPA. In ordor for your application to be IUg/bto for o>cpedhed review. you mustprovido us with the EPA Rogistration Number end product name of tho productyou balja\l1l is dmllar to oridontical to yeurproduct. TIUI productmupt bo aimiler or idanticalin both formulotlon andlobohtd u•••• 

### SeCTION II •This .ootion must ba camp/otad for all applicetion. ,ubmitted to amend th. regi.tration only of ., currentlyregioterod product IAm,ndmant). for II rasubmisslon In rcspantls to en Agancylottar, for notifieations to the Agoney. for ths IlUbmiealon offinal printed laboling. for r.regiatration and for enyothor octlon tlUlt portaimr 10 IS 'P'IIcinc EPA'rogi$tllrnd prrn:!yc\. TW, ee<;:tion Is

## ruu 19..b.!. usod for IS now application for rogi$tretion. 1. SubJeotoftubmiuioo

- Chocktho oppHccble block and provida tho Agoncy lotter doto if appropriota. Provide 0 briof axplonotlon oftho purposol1l1 for the sublnission, such Its**~tho** IIddition of a sito, post or crop tlfpocilylW;**~amand** tha Confldantial Slatemont of Formula by

...**~;** "raragi,trotion**submfstion~; ~"enor&l**  lobel revision ofulle diroctions." Attach a 1loparato page if additional spaca ill neadad• 

### •••• SECTION IIrW.ihOijJng and Containu Information)

- This Ssctlon must be complSlad for 

### 1111 application$ submitted In connaction with new rogistration or**~ealille** amendments. I. TvP. ofpa!tuW;' Cheok the ilPpropriato blockif your product wiN be packegod in the Indiceted peckeging tYPo•. Indicoto the'.q:o of tho In4iWlwai.pllcklits ond numblH por reUlii oontainar. 2. Typo ofRotf»**~~ner** ·,rn!icaJ) typo of contoinerin Which product will bo m9rkatod. 3. LOlUltion**oMt-U:~<I'tonto .~WIJ**  tho locotion oftho notcontlJnts Information for yourproduct. 4. Slut,)ofR.taH Contfllnel--**~clfy** tlUl not contGnts of aU rot&il oontainersfor your product. 5. Looution of.u

..&..ctione**~**fndilMtto tho location oftM uoo directions for your product. 6. MenrIM In**~lIicll**1-balla

# aln::tt:, product

- Indicotad ths mothQd product labal is attllchedto TOten contslnar. 

### • ••••• SECTION IY.ttl,ta)t Peint)· This Section muet bo compiotlld for all oppli(:ationll for Regi.tratlon octionll, i.II., f\ilW productfl rl:lgilltrlltion. ruubmi.&ion,**~nVft:Ib,~** rl:lrogilltrauon, etc
. 

### •••• 1-5. Self·.xvlaoa\tlr<t· G. EPA UN Only.

# •

J CERTIFIED MAIL Gail Powell 

## Registration Manager Rhone-Poulenc P.O. Box 12014 

# ,

Research Triangle Park, NC 27709 Subject: Ethephon Reregistration 

## Eligibility Decision (RED), April 28, 1995 

## Time Extension for Product Label Requirements Registration Numbers: Batch 1: 264-263, 264-543 Batch 2: 264-267,264-292,264-376 Batch 3: 264-257,264-377,264-380 

## Dear Ms. Powell: Batch4: 264-418 Batch 5: 264-511



## All Ethephon products have been forwarded to the Registration Division (RD) 

## for label review except for products which are in batch 2. The products in this batch will be forwarded to the 

### RD upon receipt ofthe primary eye irritation review. In addition, you 

## will need to 

## submit additional information for registration number 264-267 as stated in the product chemistry review that was sent to you dated February 25, 1997. Your request has been granted for a time extension to make your labeling changes. The RED states that registrants may generally distribute and sell products bearing old labels/labeling for 26 months from the date ofissuance and persons other than the registrant may generally distribute or sell such products for 50 months from issuance. Therefore, you are granted a 6 month extension to produce and use your new approved labels once you have received them from the Agency. Persons other than the registrant will be given 30 months after receipt ofthese approved labels to make the appropriate changes. MicroFlo was required to submitdata as requested in the Ethephon RED since their products were registered within days ofthe RED issuance. MicroFlo has complied with the reregistrations required and are being processed along with Rhone-Poulenc's product



# 77

# .- . '),



# • reregistrations. However, Griffin's products were registered after the RED issuance and therefore, are not subject to reregistration.
Ifyou have any additional questions, please call Wanda Daughtry at (703) 308-8171.

cc: 

# ,
Lois Rossi Barbara Briscoe Cynthia**Giles~Parker** 

### Jim Stone Sincerely, 

# / '/ 

## , Linda Propst, Chief Planning and Reregistration Branch Special Review and Reregistration Division



# 78 •

# ~ 'RHONE-POULENC

AHONE·POULENC AG COMPANY



## June 6, 1994 ETH 94-12 

### DocumentProcessing Desk (FIN·LABELS) Office ofPesticidePrograms 

### Room 266A, 

## Crystal Mall 2 

## 1921 Jefferson 

## Davis Highway Arlington, VA 22202 

## Attention Mr. Jim Tompkins Registration Support Branch 

# e OemMr. Tompkins:



# • RE: Fimli Labels for PREP Plant**l~egulator** 

## for Cotton EPA Reg. No. 264-380 

## Your letter ofaccept<1IlCe 

## dated May31,1994 Appended is onecopy ofthe final Labeling for PREP Plant Regulatorfor Cotton. There was a request to correct someofthe typographical errorson the labeling and the identified 

## letters werecircled on the EPA approval. We could find noproblem with thesomeofthe 

## words circled ex: adsorbed and bodypage MO 

## under (PPE) requirements sono changes**~'\'ere** 

## made. Theother minormodifications requested have been incorporated in the 

## appended labeL If

## you haveany questionsplense feel free to contactme.
Sincerely,



# &!**~;t**

# .JPu--"';' Wnrrcn A. Davis Senior Registr<1tion Manager

;:\Jeox 12014 :? 1"V**hEXAND~R**op,>"**R~SEAROi** iHiANGLE Pl·RK f;C :>!;,n fSI9J 5·19 2000 I/JT(RNATiONA!.. ,(LEX NUVSER**49Jj37~** AN;V;[ !<BACK /,f-'C f-lU' INr,;RNATIONAc DISTRIBUTiON**SPRV"~ES** liLFXt,uum:[1·:9'1'i3!!·· .;Ns\...,rR"J;.Cc. M C '1:3 

### •••• 

### • 

## ••



# ., 

# .

•

•• 

## • 

# · " •• 

## • • • 

## •• 

# ., 

# . ••••



### •••• 

## • •••• •••••• • 

## •• • • •

### ••••• 

### • 

## •

•• ••••• 

## • • ••••• • 

### •••••• 

## • •

•• •

### ••••• • • 

### •• ••

fxcellcncc In Performance Pr,de if)**Achleh~mel1{** 

# 79

# PREpTM 4 PLANT REGULATOR FOR COTTON FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. NOT FOR RESIDENTIAL USE. ACTIVE INGREDIENT:

Elhephon I(2-chloroelhyl) phosphonic aCid]-

........................................................................................... 39.9% 

### INERT INGREDIENTS:

......................................................................................................................... 60.1% 'This product conlains 4 pounds elhephon per galion. 

### EPA Reg. No. 264-380 EPA Est. No. 264-PA-01 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
51 usted no entiendo la otiquota, busquo a alguren 

### paraquo so la explique a ustoo on delallo. (H 

### you do not undorstand tho 

### labor. lind somoono to explain it

### to you in detail.) 

### For MEDICAL And TRANSPORTATION Emergencies ONLY Call 24 Hours A 

### Day 1-800·334-7577 For peOOUCT.lJ..S..E. Information Call 1-80()'334·9745

• he use of this product for a variety of plant growth regulation uses is covored by Unitad States and foreign patents inclUding .5. Patonts 3,879,188 and 4,240,819. No liconso is granted 

### to use this product in countries oth9rthan the United States orfor any use not contemplated by this label. liability for patent infringement may rosult from use or sale 01 this product outside 1he United States. 

## STATEMENT OF PRACTICAL TREATMENT IF IN EVES: Hold eyelids open and flush with a stoady, 90nllo stream ofwater for at least 15 minutos, GET MEDICAL ATIENTION, PREFERABLYAN OPHTHALMOLOGIST,
IF ON SKIN: Immediatoly wash with plenty of soap and water, IF SWALLOWED: Do not induce vomlting. Promptly drink a largo quanlity of milk, egg whiles, golatin solution or if theso are not available, drink largo quantities ofwater. Avoid alcohol. Call a physician immediatoly.
IF INHALED: Remove victim to frosh air. 

### If not breathing, give artilicial respiration. Administer oxygon if nocessary. GET MEDICAL 

### ATIENTION. NOTE TO PHYSICIAN eNO specific antidote is available. All treatments should be based on obsorved signs and symptoms of distross in tho patient. Overoxposuro to materials otherthan this product may have occurrod. Victims 01 severo overexposuro, by inhalation, should be kept undor modical observation lor up to 72 hours for dolayod onsot 01 pulmonary odema. In a victim of overexposure by ingestion. careful gastric lavage is roquired due to the possibility of stomach or esophagoal perforation. This material is an acid, but tho use of alka6no SUbstances to noutralizo it is contraindicated. 

## PRECAUTIONARY STATEMENTS Corrosive. Causes eye damage and skin irritalion. Do nol get in eyes, on skin, oron clolhing. 

## •

## ••••• •••• • 

## • • • 

## • • 

## • • Harmfulorfatal if swallowed. Avoid contamination offood. 

## •• • 

## •••••• • • 

## • •• 

## •••••

• • •

## •••• •• 

## • • • 

## • •

•• 

## • •••••• 

## • • 

# · 

# .. • 

## •• • 

## • 

## • ••••••



## •••• • • •• 

## •• 

## •••• 

## • ••••



# 80r-- -- ---------- ---



### ·NOTE TO PHYSICIAN No specltic antidote is available. All treatments should be 

### based on observed signs and symptoms of dislress in the patient. Overexposure to materials otherthan this product may have occurred. Victims of severe overexposure, by inhalation, should be 

### kept under medical observation for upto 72 hours for delayed onset ot pulmonary edema. In avictim ofoverexposure by ingestion, careful gastric lavage is required due to the**possibH~y**

### ofstomach or esophogeal perforation. This material is an acid, but

### the use ofalkaline substances to neutralize it 

### is contraindicated. 

### PERSONAL PROTECTIVE EQUIPMENT (PPE) Applicators and olher handlers must wear long-sloeved shirt and long pants, watorproot gloves, shoes plus socks and protectiva eyewear. When handlers usa closed systems, enclosed cabs, or aircraft in a mannerthat meets the roquiremants listed in the Worker Protection Siandard (WPS) for agricultural pesticides [40 CFR t70.240 (d) {4-6)J, the handler PPE requirements may be reduced or modified as speciliod in tha WPS. Discard clolhing and othor absorbont matorials that have boen drenched or heavily contaminated**w~h** this product's concentrate. 00 not reuso them. Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables, use detergent and hot water. Keep and wash PPE separately from other laundry,

should wash hands belore eating, drinking. chewing gum, using tobacco orusing the toilol. I I 

### ENVIRONMENTAL HAZARDS Avoid spray drift to noarby crops as this product may cause temporal'{ modifications in plant growth. Do not contaminato water used for irrigation ordomostic pUrp05as. Forterrestrial uses, do not apply directly to watar, orto areas where surfaco water is prosent or to intertidal areas below the moan high water mark. 00 not contaminate water when disposing ot equipment washwaters. 

### Do not excoodthe rata of PREPnoi per acre per year recommended on this label. 

# DIRECTIONS FOR USE It 18 8 violation of Federal law to use this product In a manner Inconsistent with Its labeling. Read entlr. label before usIng thIs product. 

# _Do not apply this product In a way that will conta.ct workers 

### orother persons,

### e~her directly or through drift. Only protected handlers may 

### be in the aree during application. For any requirements specific to 

### your State or Tribe. consult the agency responsible for pesticide regulations. 

### AGRICUL I 

### URAL USE REQUIREMENTS Use this product only in accordance with Its labeling and with the Worker Protection Standard. 40 CFR part 170. This standard contains requiremants for the protection of agricultural workers on tarms, forests, nurseries. and greenhouses, and handlers 01 agricultural pesticides. It contains requiremenls for training. decontamination. notification, and emergency assistance. It also contains 

### imU<; instructions and exceptions pertaining to the statements on this label about personal protective equipment**{~~** llotilicftiorttez workers and restricted-entry interval. The requirements In this box only apply to uses of this product that are covel'Od**~y** the ytot1<fr Protection Standard. • • 

## •• Do not enterorallow worker entl'{ into treated areas during the restricted-ontry interval (REI) of 48 hours. ••••• PPE required lor early entry to treated areas thai is permitted underthe Worker Protection Standard and that

### inf~lvls conlMl.:With anything that has been treated such as plants. soil orwater is coveralls, waterproof gloves, shoes plus socks and'P.rotOOlive eyewoar. -" 

# ... Notiw workers of the application by WaminQ them orally and posting warninq siQns at entrances to treated areas. •• • ••


# .

# .. •• 

## •

•••• GENERAL INFORMATION

.... 

## '" 

# .. • 

## • 

# ... Afoliarspray of PREpm 4 Plant Regutatorwill accelerate opening ot mature unopened cotton bolls andm-rance defoliation which can result in earlier harvest with an increased recoverable yield. PREPTM 4 Plant Regutatortreatment allows increased efficiency from a once-over harvest. 

# 81

### ·Some premature drop ot small, immature bolls may be

### associatedwith treatment. 

### Do not apply betore sufficient, mature, unopened bolls have developed to produce the desired yield of coUon. Aboll is mature when it 

### is too hard to be dented when squeezed between thumb and lingers. too hard to be sliced with a sharp knite, and when the seed coat becomes light brown in color. Forbest results, thorough and uniform spray coverage is required. It is essential that the bolls are contacted by

### the spray to obtain optimum boll opening. Observe treatedfields closely. Harvest at optimun boll opening and defOliation, generally 14 to 21 days aftertreatment. Sustained coldweatherwith average day and nighttemperatures of65°F orlowerafter treatmentwilh PREf'TM 4 Plant Regulatorwill delay the boll opening response. DO NOTAPPLY PREprn 4 PLANT REGULATOR IF RAIN IS EXPECTED WITHIN 6TO BHOURS. Rainfall within 6to 8 hours ofapplication may reduce producl performance. Certified cotton seed growers should observe boll and seed maturity betore treatment with PREpTM 4 Plant Regulator. Bolls not completely mature m'lghtopenwith treatment at PREpnt 4 Plant Regulator giving lowerquaflty seed. Spray deposits of PREpm 4 Plant Regutator, when lefton aircraft acrylic plastic

## type windshields tor longerthan 1hour, may reactwith this material, forming an opaquefilm orspots on the surfacewhich cannot be 

### removed bywashing with waterorany othercleaner. Rinse windshields with water immediately aftereach tankload of PREpnt 4 Plant Regulator has .eenapplied. Thoroughly rinse the aircraftwith clean wateraltereach day PREpTM 4 Plant Regulator is applied. PREpn.t 4 Plant Regulator may also aUeci certain paints, and 

### ifaccidental deposits on painted objects such as cars, trucks, agriculturaf equipment, etc. occurs, these objects should be rinsed with water as soon as possibte (within 1 hour) to prevent permanent staining ofthe painted surface. 

### SPRAY PREPARATION Add 1/2 to 3/4 ofthe required amount at waterto the spraytank. Start agitation. Add the required amount of PREpt'M 4 Plant Regulator. and the remaining amount ot water. Prepare only as much spray solution as can be used on Ihe dayof mixing. 

### Do not allow spray solution to stand overnight. Do not spill the concentrated product on spray equipment. orany airplane parts. ANY SPILLS SHOULD BE RINSED IMMEDIATELYWITH PLENTY OF WATER. Use of a nurse tank is highly recommended toravoiding possible spillS at concentrated tormulation on spray equipmentor any airplane parts. 

### EQUIPMENT CLEANING

_ Because at the acidic nature ot this product, prolonged exposure to spray depositwill damage acrylic plastics, certain paints, and metals. Rinse thoroughlywith adetergent and waterall exposed acrylic plastic-type materials (e.g., aircralt windshields), and painted surtaces wijhjn an hour atter exposure to spray deposits. AI the end of

### each day. rinse thoroughlywith a detergent and water all the metat parts 01 the aircraft and the associated spray equipment exposed to the spray deposits

.

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# 82

### aOLL**OeE~I~G** 

### Rates For Boll Opening CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 5·7 DAYS AFTER PREP"'4 OF PREP'"4 GAl.lACBE 

### TREATMENT OUARTS/ACRE TREATS GROUND AIR Hot and dryaO"F or higher 1.0 (1.0 Ib a.i.) 4Acres 

### 151050 

### 2

### to 5- Drywith temperature 1.5 (l.Slbaj.) 2.5 Acres 

### 15 to 

### 50 2 

### to 5- 7S"Flo 80"F Cool but higherthan 65'F 

### 2.0 (2.0 Ib aJ) 2Acres 

### 15 

### to 50 2 

### to S" Rank cotton 

### 2.0 (2.0 Ib a.i.) 2Acres 

### 25 to 

### 50 5 ·NOTE: 

### For California and Arizona use avolume of no less than 5gallons peracre foraerial applications Time of Application (Boll 

### Opening) MPPlywhen there are sufficient mature unopened bolls to produce the desired yield. but no laterthan when 60%ofthe 

### 8011sare opened (see Generallnforrnation section on how to test for boll maturity). 

### Do not lank mix PREPT'loI 4 Planl Regulatorwith a desiccant if

### the cotton isto be 

### spindle harvested. PRECONDITIONING FOB DEfOLIATION 

### Bates For preconditioning For DefOliatioD
CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 5·7 DAYS AFTER PREPl'M 4 

### OF PREP'"4 GAL.IACRE TREATMENT OUARTs/ACRE TREATS GROUND AIR Hot and 

### dry 80'For 

### higher 0.5 (O.S Ib a.i.) a Acres 15to

### SO 2 to 

### S· Cool but higher than 65"and 1.0 (1.0 

### Ib aj.) 

### 4 Acres 

### 1S to 

### 50 2 to 

### S· also for rank cotton _·NOTE: ForCalifornia and Arizona use avolume of no less than 

### 5 gallons peracre foraerial applicalions. 

### Time of Application (preconditioning) Apply 

### PREprn 4 

### to 7 

### days priorto application of deloliantortank mixedwith the defoliant (see section on Compatibility). 

### Do not tank mix PREpTM 

### 4wllh desiccants unless plant desiccation is required.**pre~treatment** 

### With Defoliants prior to PREpTM 4 plant Regulator Treatment If 

### Ihe cotton is overly rank orlaying down in the 

### middles and good 

### spray 

### coverage ofthe bollswith PREPfU 4 

### Plant •••••• Regulator isdifficult, a prelreatmentwith defoliantswill be 

### useful to improve boll coverage with PREprM 4**'PI~flL**

### Regtliat!fr. : Use dosage rales of PREpTloi 4 

### Plant Regulator recommended for boll opening. Read and observe all apt)foprfate labe' ••• use directions and precautions for the defoliant used. • •••• 

## ••••• Do not use a delolianl before there are sulfic/ent mature unopened bolls to produce the desired yield (see General ••: ••• Informalion section on howth testfor 

### BoU Maturity). •••••• • 

## ••• 

## •••••• COMPATIBILITY • •••• PREpTM 4 Plant Regulator is 

### compatible with DEF, FOLEX, DROPP, HARVADE, METHYL

### PARATHION,:~tHION ANJ> •• MALATHION. 

### and may be applied in sequence oras a lank**m~tur.** 

### (DO NOTTANK MIX WITH**DEFOLlANT~QR** 

### ..... DESICCANTS IN CALIFORNIAAND ARIZONA). In some cases slight reduction in boll opening respon!iftN-s been observed when tank mixes with defolianls were used.


# 83

### 'Good agitation in the spray tank is essentiat and atank mixture should not be 

### allowed to stand without agitation for more than 5 to 10 minutes. Read and observe aU appropriate label use directions and precautions forthe defoliants and insecticides used, PRECAUTION: DO NOTTANK MIX PREP'"4 PLANT REGULATOR WITH DEFOLIANTS CONTAINING SODIUM CHLORATE BECAUSE THIS RESULTS IN TIHE FORMATION OF HYPOCHLOROUS ACIDS WHICH UPON HEATING EMITTOXIC CHLORINE FUMES. 

### WHEN TO HARVEST: 

### Do not harvest cotton soonerthan 7days aftera treatment wilh PREprn 4 Plant Regulator, Observe the treated crop and harvest when optimum boll opening has been reached. Too early harvest might reduce the fun advantage ofthe treatment and too late a harvest may result in reduced quality and loss of lintwhich will dropfrom the plant. USE PRECAUTIONS 

### Avoid spray drift to nearby crops as this productwill 

### cause modifications in plant growth. Plant injuryor reduced yields will result. Do not plant anothercrop within 30 days aftertreatment. Mix only the amount ofsprayyou 

### expectto use each day. 

### Do not allow mixed sotution to stand overnight.

STORAGE AND DISPOSAL

# ~ not contaminate water, food, orfeed by storage ordisposal.**:t~.1.'7IUt** 

### DISPOSAL 

# I**~:;~~I~I~::.wastes** are acutely hazardous. Improperdisposal of excess pesticide, spray mixture, or rinsate 

### is aviolation of**I~** 

### Ifthese wastes cannot be 

### disposed of by use according to label instructions, contact yourState Pesticide or Environmental Control Agency orthe Hazardous Waste representative at the nearest EPA Regional Olficeforguidance. CONTAINER DISPOSAL 

### Triple rinse (or equivalent) the empty containers. Then offerfor recycling or reconditioning, orpuncture and dispose of in 

# I**~=k~a"** 

### landfill. or by incineration or ifallowed by state and local authorities, by burning. Ifcontainer is bumed, stay out of 

# •

•

### ••••• •••• 

## • 

## • • • • • • 

## •

•• 

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### • • 

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# 84

# I L. LIMITED WARRANTY AND DISCLAIMER The manufaclurerwarrants (a) that this product conforms to the chemical description on the label; (b) 

### that this product is reasonably

### fit forthe purposes set forth in 

### the directions 

### toruse when 

### it is used in accordance with such directions; and (c) that the directions, warning and other statemenls on this labet are based upon responsible experts' evalualion of reasonable tests of effectiveness, oftoxicityto laboratory animals and to plants, and of residues on food crops and upon reports offield experience. Tests have not been made on allvarieties or in all states orunder all conditions. THE 

### MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES ITAUTHORIZE ANYAGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANTAEILITY OR FITNESS FOR A PARTICULAR PURPOSE. THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANYAND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL DIRECTIONS, WARNINGS OR CAUTIONS. BUYER'S EXCLUSIVE REMEDYAND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER OR NOT BASED IN CONTRACT, NEGLIGENCE, STRICT L1AEILITY IN TORT OR OTHERWISE SHALL BE LIMITED, ATTHE MANUFACTURER'S OPTION, TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE _RICE FOR, THE QUANTITY OF PRODUCTWITH RESPECTTO WHICH DAMAGES ARE CLAIMED. IN NO EVENT _HALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECTOR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OFTHIS PRODUCT

.



# •

RhOna·PouloncAg 

### Company P,O. 

### &x 12014, 2T.W. Aloxander DriVe Research Trianglo Park. North Carolina 27709 PREP is a trademarkof RHONE-POULENC. PREP'"" 4 Planl Regulator for Colton (MASTER) Notification **4/14194,** Approved **5/31/94.** 

## •••• 

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# 85 

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# .. ••••••



# • • 

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# •

• UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460



### Warren A. Davis RHONE-POULENC AG COMPANY 

## P. O. Box 12014 Research Triangle Park, NC 27709 

## ,·1.-',( 3 J 

## 1594

OFFICE Of PREVENTION, PESTICIDES AND TOXIC SUSSTANCES



### SUbject: Label Amendment Submission of 

### 04/18/94 in Response to PR Notice 93-7 EPA Reg. No. 264-380 PREP PLANT REGULATOR FOR COTTON


### Dear Registrant: The labeling 

### ciled above and submitted in connection with registration under the Federal 

### Insecticide, Fungicide. and Rodenticide Act (FIFRA). as amended, is accepted subject JO 

### the comments reflected on the enclosed sheet. A copy of your proposed labeling stamped "ACCEPTED WITH COMMENTS" is enclosed. WHAT THIS ACCEPTANCE MEANS: 

### Based on your certification, the Agency has accepted the labeling changes Ihat are necessary 10 

### comply with the Worker Protection Standard (WPS) labeling requirements of 40 CFR 

## part l56, subpart K, described in PR Notices 93-7 and 93-11. Any other labeling changes submitted in cOIUlection with this amendment application but not directly related to compliance with the WPS have ltot been reviewed or accepted by the Agency. I f you wish to make such changes, you must submit a separate amendment application proposing them. If your produci is currently suspended, the acceptance ofthis labeling amendment does not affect Ihe suspension in any way. WHAT YOU NEED TO DO NEXT: By (he next label printing make all the specified changes to 

### your labeling. Send to EPA one (I) 

### copy of the final printed labeling:

• BEFORE selling or distributing any product bearing (he final printed labeling AND • WITHIN one year from date of Ihis acceptance,

# •

• Page 2

SUblll1l [he 

### (inal primed 

### labeling Via [he 

### U.S. Postal Service 10: 

## Document Processing Desk (FI**N~LABEl)** 

### Office of Peslicide Programs (7505C) 

## U.S. Environmental Protection Agency ·101 M Street. SW Washington. D.C. 10460·0001



## Hand or courier deliveries of final primed labeling may be made 10:



### An3chmem 

## Document Processing Desk**(FtN~LABEL)** 

### Office of Pesticide Programs Room 16M. 

## Crystal Mall 2 1911 Jefferson 

## Davis Highway Arlington. VA 21102

## \~incer/\ / .\

### ',-,/~,**~ /t~<·-**  

## Jim pkin Deputy Chief

## R~gistration upport Branch 

## Registration Division (7505W)



# ./

87**~---~~~~~-**


# PREpTM 4. PLANT REGULATOR FOR COTTON FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. NOT FOR RESIDENTIAL USE. ACTIVE INGREDIENT:

Ethephon [(2-chloroethyt) phosphonic acid]*

...............................".,."

.........................."

.........................39.9% 

### INERT INGREDIENTS:

......................................................................................................................... 60.1% 

### *This product contains 4 pounds ethephon per gallon. EPA Reg. No. 264·380 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
SI usled no entiende 

### ta etiquela, busque a algulen para que sa la expnque a usled en detalle. (Ifyou do nol understand the label, find someone to explain it to you in delail.)

# FOr1~J:Aii<i:ffiA
use of this product for a variety of plant growth regulation uses is covered by Uniled States and foreign patents Including Patents 3,879,188 and 4,240,819. No license is granted to use this product in countries other than the United Slates or for any use not contemplated by thIs label. Liability for patent Infringement may result from use or sale of this product outside the United States. 

## STATEMENT OF PRACTICAL TREATMENT IF IN EYES: Hold eyelids open and flush with a steady, genlle stream ofwater for at least t5 minutes. GET MEDICALATTENTION, PREFERABLY AN OPHTHALMOLOGIST.
IF ON SKIN: ImmedIately wash with plenty of soap and water.
tF SWALLOWED; 

### 00 not induce vomiting. Prompily drink a large quantity of milk, 

### egg whites, gelatin sotution or ilthese are not available, drink large quantities ofwater. Avoid alcohol. Call a physician immediately.
tF INHALED: Remove victim to fresh air. If not breathing, give artificlaf respiration. Administer oxygen if necessary. GET MEDICAL ATTENTION. _JeTE TO PHYSICfAN No specific antidote is availabte. Alt treatments should be based on observed signs and symptoms of distress in the patient. Overexposure to materials other than this product may have occurred. Victims of severe overexposure, by tnhatation, shOutd be kept under medicat observation for up to 72 hours for delayed onset of pulmonary edema. tn 

### a victIm of overexposure by ingostion, careful gastric lavage is required due to fhe possibility of stomach or esophageal perforation. This materialis an acid, but the use of atkaline substances to neutralize it is contraindicated. 

## PRECAUTIONARY STATEMENTS Corrosive. Causes eye damage and skin irritation. Do not get

### in eyes, on skin, or

### on clothing. Harmful orfatal if swallowed. Avoid conlamination offood.

ACCEPTED wilh COMMENTS In tPA {..,ll

..r nalt"t 

### \j/\Y J 

## ! i:>:H HUller Ihc }'m!eral tMe<:tidd6o, Fu

... lidM, lind Hoocnlirlde Ad**,,~ .u"~nd** ..d. rur Inc pealielde r.·."i.'kr",1 wlltc;r tWA Rfi' Nu

.



## .07£-I,:-.Jo 

# 88

### NOTE TO PHYSICIAN No specific antidote is available. All treatments should be based on observed signs and symptoms ofdistress in the patient. Overexposure to materials other than this product may have occurred. Victims ofsevere overexposure. by inhalation, should be kept under medical observation for up to 72 hours fordelayed onset of pulmonary edema. In a victim 01 overexposure 

### by ingestion, careful gastric lavage is required due to the possibility ofstomach or esophogeat perforation. This material is an acid, butthe use of alkaline substances to neutralize 

### it is contraindicated. 

## PERSONAL PROTECTIVE EQUIPMENT**~PPE)** Applicators and other handlers must

## We~IOng.sreeved shlfJand long pants, waterproof gloves, Shoes plus socks and protective eyewear. When handlers use closed systems, enclosed cabs, or aircraft In a mannerthat meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides 

### {40 CFR 

### 170.240 (d) (4-6)J, the handler PPE requirements may be reduced or mcxflfied as specified in the WPS. 

# t
Discard clothing and other abso

## e~ materials that have been drenched or heavily contaminated with this produci10ncentrate. 00 not reuse them. Follow manufac urer's Instructions for cleaningJmaintaining PPE. If no such Instructions torwashal51es. use detergent and hot water. Keep and wash PPE separatelyfrom other laundry

. 

# •**r---------~==~=n=======_--------__,** User Safety Recommendations Users

### Shoul~wash hands betore eating, drinking, chewing gum, using tobacco or using the toilet. Remove clothing Immediately if pesticide gets inside. Then

# waS(b~~~**~hOrOUghlY** and put on clean clothing. 

## ENVIRONMENTAL HAZARDS Avoid spray 

### drift to nearby crops as this product may cause temporary modifications in plant growth. Do not contaminate water used for Irrigation or domestic purposes. Forterrestrial uses, do not apply directlyto water, orto areas where surface water is present orto intertidal areas below the mean high water mark. Do not contaminate waterwhen disposing ofequipmentwashwaters. Do not exceed the rate of PREP"" peracre peryear recommended on this tabel. 

# DIRECTIONS FOR USE It fs a vtotation of Federat Law to use thts product In a manner Inconsfstent with Its tabellng.

__ Read enUre label before usfng this product. Do not apply this product in away that will contact workers or other persons, either directly or through drifl. Only protected handlers may be in the area during application. For any requirements specific to your State or Tribe, consult the agency responsible for pesticide regulations. 

## AGRICULTURAL USE REQUIREMENTS Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR part t70. This standard contains requirements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural pestlcfdes. II contains requirements for training, decontamination, notification, and emergency assistance. It also contains specific instructions and exceptions pertainjng to the statements on this label about personal protective eqUipment (PPE), nolification to workers and restricted-entry**Interv~sl** The requirements In this box only apply to uses of this product that are covered by the Worker Protection Standard. 

## v Do not enteror allow worker entry into treated areas during the restricted-entry intervat (REI) of 48 hours. PPE required tor early entry to treated areas that is**permil~?p** under the Worker Protection Standard and that Involves contact with anything that has been treated such as plants, soil orwater e}::overalls, waterproof gloves, shoes plus socks and protective eyewear. Notify workers ofthe application bywarning them orally and posting warning siQns at entrances to treated areas.


### GENERAL INFORMATION A foliar spray of PREpnt4 Ptant Regulatorwill accelerate opening of mature unopened cotton bolts and enhance defoliation which can result in earfier harvest with an rncreased recoverable yiefd. PREpn.14 Plant Regulatortreatment allows Increased efficiency from a once-over harvest. 

# 89

### Some premature drop ofsmall, immature bolls may be associated with treatment. Do not apply before sufticient, mature, unopened bolls have developed to produce the desired yield of cotton. A boll is mature when it is too hard to be dented when squeezed between thumb and fingers, too hard to be slicedwith a sharp knife, andwhen the seed coat becomes light brown in color. For best results, thorough and uniform spraycoverage is required. II is essential that the bolls are contacted by the spray to obtain optimum boll opening. Observe treated fields closely. Harvest at oplimun boll opening and defoliation, generally 14to 21 days aftertreatment. Sustained cold weatherwith average day and night temperatures of65°F or lowerafter treatment with PREpn.! 4 Plant Regulatorwill delay the boll opening response. DO NOT APPLY PRE!='4 PLANT REGULATOR IF RAIN IS EXPECTEDWITHIN 6TO 8HOURS. Rainfall within 6 to 8 hours ofapplication may reduce product performance. Certified cotton seed growers should observe boll and seed maturity before treatment with PREpTM 4 Plant Regulator. Bolls notcompletely mature might open with treatment of PREP'fM 4 Plant Regulatorgiving lowerquality seed. Spray deposits of PREpt'M 4 Plant Regulator, when left on aircraft acrylic plastictype windshields for longerthan 1 hour, may react with this material, forming an Opaque film orspots on the surface which cannot 

### be removed bywashing with .rmterorany othercleaner. Rinse windshields with water immediately aftereach tankload of PREPTM 4 Plant Regulator has .,eenappUed. Thoroughly rinse the aircraftwith clean waterafter each day PREpn.! 4 Plant Regulator is appned. PREPTM 4 Plant Regulator may also affect certain paints, and ifaccidental deposits on painted objects such as cars, trucks, agrtcultural equipment, etc. occurs, these objects should be rinsed with wateras soon as possible (within 1 hour) to prevent permanent staining ofthe painted surface. 

### SPRAY PREPARATION Add 

### 1/2 to 3/4 ofthe requJred amount ofwaterto the spray tank. Start agitation. Add the required amount of PREpTM 4 Plant Regulator, and the remaining amount ofwater. Prepare only as much spraysolution as can be used on the dayof mixing. 00 not allow spray solution to stand ovemight. Do not spill the concentrated product on spray equipment, orany airplane parts. ANY SPILLS SHOULD BE RINSED IMMEDIATELYWITH PLENTYOF WATER. Use ofa nurse tank is highly recommended foravoiding possible spills of concentrated formulation on spray equipment or anyairplane parts. 4IIillUIPMENT CLEANING ecause ofthe acidic nature ofthis product, prolonged exposure to spraydeposit will damage acrylic plastics, certain paints, and metals. RinSe thOroughly with adetergent and waterall exposed acrylic plastic-type materials (e.g" aircraft windshields), and painted surfaces within an hour afterexposure to spray deposits. At the end ofeach day, rinse thoroughly with a detergent and waterall the metal parts of the aircraft and the associated spray equipment exposed to the spraydeposits.



# 90

### IlQLL QeENING Rates 

### For Boll Opening CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME S-7 DAYSAFTER 

### PREpTM 4 OF PREP'"4 GAL.IACRE TREATMENT QUARTS/ACRE TREATS GROUND AIR 

### Hot and dry 

### eO"F or higher 1.0 (1.0 Ib aJ.) 4Acres 

### 15to 

### 50 2

## to S" Dry**w~h** temperature 

### 1.S (1.Slb aJ.) 2.5 Acres 

### 15

### to 50 

### 2

### to 5- 7S"Fto OO"F Cool but higher than 6S"F 

### 2.0 (2.0 Ib aJ.) 2 Acres 

### 15 to 

### 50 

### 2 

### to 5- Rank cotton 2.0 (2.0 Ib aJ.) 2 Acres 

### 25

### to 50 

### S 

### -NOTE: ForCalifornia and Arizona use avolume of no less than 5gallons peracre foraerial applications 

### .fme of Application (Boll Opening) pply when there are suffiCient mature unopened bolls to produce the deSired Yield, but no later than when 60% ofthe 

### bolls are opened (see General Information section on how to testfor boll maturity). Do not tank mix PREPlM 4 Plant Regulatorwith a desiccant 

### if the cotton isto be spindle harvested. PRECQNDITIQNING EQR DEEQLIATIQN Rates For Preconditioning For Defoliation
CONDITIONS EXPECTED S-7 DAYS AFTER TREATMENT Hot and 

### dry BO'F orhigher 

### PREpTM 4 QUARTS/ACRE ONE GALLON OF PREP'"4

TREATS 8 Acres 

### SPRAY VOLUME GAL.IACRE GROUND AIR 

### 15 to 

### 50 2 

### to 5* 

### Cool but higher than 65'and 1.0V.O Ib aj.) 4Acres 15 to 50 2 to 5- 

### also for rank cotton -NOTE: For California and Arizona use a volume of no less than 5gallons peracre foraerial applications. Time of Application (Preconditioning) 

### Apply PAEpt'M 4 to 7 days priorto application of defoliant ortank mixed with the defoliant (see section on Compatibility). 

### Do no1 tank mix PAEf'TM 4with desiccants unless plant desiccation is required,**Pre~treatment** 

### With Defoliants Prior to pREen! 

### 4 Plant Regulator Treatment Ifthe 

### coHon Is overly rank orlaying down in the middles and good spray coverage ofthe bolls 

### with PREpTM 4 Plant RegUlator is difficult, a pretreatment with defOliantswill 

### be uselut to improve boll coverage with PREpThl 4 Plant Regulator. Use dosage rates of PREpTM 4 Plant Regulator recommended for boll opening. Read and observe all appropriate label use directions and precautions forthe defoliant used. Do not use a defoliant before there are sufficient mature unopened bolls to produce the desired yield (see General Information section on how th test for8011 Maturity). COMPATIBILITY 

### PREf»M 4 Plant Regulator is compatible with DEF, FOLEX, DROPP, HARVAOE, METHYL PARATHION, GUTHION AND MALATHION, and may be 

### applied in sequence oras atank mixture (DO NOTTANK MIX WITH DEFOLIANTS OR DESICCANTS IN CAUFOANIA AND ARIZONA). In some cases slight reduction in boll opening response has been observed when tank mixes with defoliants were used,


# 91

### Good agitation in the spraY,tank is essential and a tank mixture should not be allowed to stand without agitation for more than 5 to 10 minutes. Read and observe all appropriate label use directions and precautions forthe defoliants and insectlcides used. PRECAUTION: DO NOTTANK MIX PREP'" 4PLANT REGULATOR WITH DEFOLIANTS CONTAINING SODIUM CHLORATE BECAUSE THIS RESULTS IN THE FORMATION OF HYPOCHLOROUS ACIDS WHICH UPON HEATING EMITTOXIC CHLORINE FUMES. WHEN TO HARVEST: Do not harvest cotton soonerthan 7days aftera treatmentwith PREpn' 4 Plant Regulator. Observe the treated crop and harvest when optimum boll opening has been reached. Too early harvest might reduce the full advantage ofthe treatment and too late a harvest may result in reduced qualityand loss of lintwhich will drop trom the plant. USE PRECAUTIONS Avoid spraydrHtto nearbycrops as this product will cause modifications in plant growth. Plant injury orreduced yields will result. Do not plant anothercrop within 30 days after treatment. only the amount ofspray you expect to use each day. Do not allow mixed solution to stand overnight.
STORAGE AND DISPOSAL RAGE not contaminate water, food, orfeed by storage or disposal. PESTICIDE DISPOSAL Pesticide wastes are acutely hazardous. Improperdisposal ofexcess pesticide, spray mixture, or rinsate is aviolation of Ifede,

.. 

### law. Uthese wastes cannot be 

### disposed of by use according to label instructions, contact yourState Pesticide or Environmental Control Agency or the Hazardous Waste representative at the nearest EPA Regional Olfice torguidance. 

# • DISPOSAL (orequivalent) the empty containers. Then offerfor recycling or reconditioning, or puncture and dispose of in landfill, or by incineration orifallowed bystate and local authorities, by buming. Ifcontaineris burned, stayout of



# 92

### LIMITED WARRANTY AND DISCLAIMER The manufacturerwarrants (a) that this product conforms to the chemical description on the label; (b) thatthis product is reasonably litforthe purposes set forth inthe directions for use when 

### it is used in accordance with such directions; and (c) thatthe directions, warning and otherstatements on this label 

### ate based upon responsible experts' evaluation of reasonable tests of effectiveness, oftoxicity to laboratory animals and to plants, and of residues on food crops and upon reports offield experience. Tests have not been made on all varieties orin all states or underall conditions. THE 

### MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT AUTHORIZE ANYAGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANTABILITYOR FITNESS FOR A PARTICULAR PURPOSE. THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR. ANY AND ALL LOSS OR DAMAGEWHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL DIRECTIONS, WARNINGS OR CAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, LOSSES. DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OFTHIS PRODUCT, WHETHER OR NOT BASED IN CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR OTHERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTION, TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE _RICE FOR. THE QUANTITYOF PRODUCTWITH RESPECTTO WHICH DAMAGESARE CLAIMED. IN NO EVENT**~HALL** 

### MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OFTHIS PRODUCT

.



# •

Ahone·Pourenc Ag Company P.O. Box 12014, 2T.W. Alexander Drive Research Triangle Park, Norlh Caronna 

### 2n09 PREP 

### Is atrademark 01 RHONE-POULENC. PREprn 4 Plant Regulator forCotton (MASTER) Notification4114194.



# 93

# (,1' RHONE-POULENC**~** , "2" , RHCNE,POULENC AG COMPANY



## April 18, 1993 U, 5, 

## EPA: Worker Protection Standard 

## c/o NCI Information Systems 8260 Greensboro Drive, Suite 400 McLean, V A 22102 RE: PR-Notice 93-7 Worker Protection Standard Label submissions for: • PREP for Cotton EPA Reg No 264-380



# • Appended are Worker Protection Labels for PREP brand Ethephon Plant Regulator for 

## Cotton. To complete our submission we are including: 1. 

## A completed application for amended registration 2. A 

## certification statement that indicates fun 

## compliance and references the categories of acute toxicity llsed to 

## complete the WPS 3. Two copies of current labeling market to indicate wording deleted to comply with WPS 4. Five copies of proposed labeling (two highlighted to identify changes) with worker protection standard additions highlighted

. 

## Ifyou have any questions please feel free to contact us promptly.
Sincerely,

j 'J 

# j /)**~** 

### {;/@['oc ,,0 

# :t:6t.{f2 Warren A. Davis Senior Registration Manager

PO BOX 12014 2 TW f<L[XAN0lR C+li\'t R1'SEARCH TRIM,GU' PARK .'i C 17Nj\l {91\l)54?-20C:0**11{TtJ1NATION'\~** TELEX NU'AB(R 4929315**~NSWlRBACK** APC G,P**JNT~RNATtONAl** OISTRIBUTiON SERVICES**TFl_f~** ,-ur.mE"**~99<)3!7** -"-NSI',EI1GACK APC JiX; Exce!fence In Performance Pnde Ifi Ac/1levernen! 

# 94 1- t

# • WORKERPROTECTIONSTANDARD CERTIFICATION STATEMENT
Icertifythat therevised labelingbeingsubmitted for: PREP brand etbepbonPlantRegulator for Cotton EPA REG NO. 264-380

is incompleteaccordance with thelabelingrequirementsofPRNotice93-7, whichreflects 

## therequirementsofEPA's labelingregulationsfor workerprotectionstatements (40 CFR part 156, 

## subpartK). Whereexact languageis specified in the PR Notice, Ihaveused that languageexactly, in 

## thelocation specified. I further certifythatno revisions arebeing submitted otherthan those directed byPR Notice 93-7. Iunderstand thatit wouldbe a violationofRPRA 

## ifIormysupplemental registrants wereto sell ordistributethis product afterApril 21, 1994, withoutamended labeling complyingwith therequirementsof40 CFR part 156, SubpartK. 

# Idj".

# ,ar**diif</'"~** 4/18/94 Warren A. Davis SeniorRegistrationManager



## Theacutetoxicity categories (I, II, III, IV) for this productas entered inblocks 3-7 on PartI oftheProductWorksheet are: _3_ Acute oral toxicity _3_ Acutedermal toxicity _4_ Skin irritation potential _1_ Eye irritation potential _4_ Acuteinhalation toxicity



# 95

## . 

# ',

. PI, '"' 

# '0
Unitod Stotes 

# §Registration opp tdontifh" Number 

# .oEM Environmental Protection Agency Amendment 

# 217706 W01lhington, DC 20460 

## Other lIor


# - I 1. Compony/Product Number 

### 264-380 

# l2. EPA Product Mllnogot 

# 13. Proposed CI8uifICotion C. G. Parker ONono 

# D Rostricted 

## 14. Company/Product (Namo) PM' 11l"l':IA 

### Plant 

### Regulator 22 is. Nama and AddrOl'1I ofApptlcont {lncludo ZIP Codo} 6. Expedited Reveiw. In accotdance with FIFRA Section 3{cH3) 

### Rh6ne-Poulenc Ag 

### Company (bHil. my product is similar or identical in composition and labeling 

### 2 T- 

## w_ alexander 

### Drive to: p- O

....**~~x~** 12014 EPA Reg. No. 

### Triangle Park, NC 27709 [ ] Chockifthisis 8 nowaddress 

### Product Name
I

- 

## II 

# I!

Am,odm,"" 

# ,,,',i' b",w. 

# 0 Rnlll print&<! labols in topsonlO to Agency lottot dotod

. RosubmlSllion in rosponse to Agoncy lottor dotod**~**___**~~_** 

# 0**~Mo Too~**  Applicotion. 

# D Notilication

- EXplain bolow. 

# 0 Olher· Explain bolow.

Use 4dditional plIgols) il ncCOSIIOry. (For soction I and Section It.) 

### Amended 

### for Worker Protection Standard. PR Notice 93-7



### -III j
_ 

# "',du'" lin' P$ckoging Unit P$ckoglng Watar Soluble Pock$ging 2. Typo of Container 

# BY" ,.. y" 

# ,. y" 

# §iT"· N, 

### f- N, 

### f- Plostic 

### N, Gloss 

### must II**'Yas~** No. per If**~Ye\l~** No. per Popor 

### be-submlttsd Unit Packaging wgt. contaln(lt Pockllgo wgt container Othor I 3.' Not 

# , 14.

# Si,,'" Ro'. >o/L,b,' , 

# o Lob,1 

# 0 - 6. Monnar in Which Lebol is Alfixoo to Product

# ~ 

# o Other 

## -IV 1. Contact Point (Ccmp/flfe items directly below for ofindividual to btl contacfed, ,thi •• Name Tille Talaphone No. Itncludo Atea CodoJ 

### Warren A_ 

### Davis Isenior Registration Mgr. Certification 6. Dllto Application Icortify that tha statements I hovo mOOo on this lorm and ell ottechffientB**t~ralO** lUO trull, eccurote end complata. Receivod IIIcknowledge that anyknowlinoily la/so ormisleading IItatament may bo punishable by fino or**irJ1P!i$o~"'ft** or 

### • •• (stamped) 

# • • • bothundor I law. :.: :_. 

## • • 

## • ••• • • 

# : 

# - 

# .- • • 2. Signature 3. ndo 

### • • 

## • Senior Registration Manager 

# -';**-:~** I'" 'ypoo Nume 5. Doto 

### ••• • • 

## • • 

# ·.: 

# . Warren A_ 

### Davis April 1

## a, 1994 

### • 

# ···QR

, ••70-1 1,*'.3-941 

# , 

# , Whh.

- EPA Fil. C""y y,'ow·

.

# ---------------
----- - 

## --- 

# ._..**AAf~** 

## REDUCTICH AtT mItE: Public**~ina** irurdIm 1fU' this roU«:::tfoo t:rf fnfOf".Sll)tioo is estll!l2ttd to

_ ... 0.85 hoot" per 'up6fUe. including time 101" rmwillG inetruttiCf'ij.**H:et¢M~** «misting 

### data :toon;>m:, gathering and aaintainil'l9 the data M!.!dcd, and cct!!pteting and tm'icufna 

### ttm- eotles:ticn of hrfonmtion. SCO::I**~t$** reaarding the**~** m:;timete Of'" t:.frt other mpect of this coUection of**i~tien.** inctuding**~tiCl'l$** {Of' nlWI;ing this burden. to Chfef. Jnfonmtfen**~i** icy**9r-lIiOCh~** f>M·223. I1.S.**Envf~t' Protecticn~.**  401 It Street_**$IJ~** lJeshi09ton. l'X: 2fi46O; l'!II'Icl to the Office of Inf()niEItiOl1 lItld RS9Uillltcry Aftain=:, OffiCI: of MIs Q,**~** and**~t~** Udhineton4 DC 20503. lhh: fortA' is to be UU:d for lIU lIflplieatiana fw rev rmei:tratioo. end IRe reregh.tratlon. mendrMnt. ;--;;C--'icetions for notffieatiCll'lS-. final prfnHd l_ling, reregi$tratioo. etc. in**~** to prOCII$S an oppi ication a MIl regfttratien stafttcd 00 thi$ fon:r., the foUowing IIIttet'iai II1USt**~** the appi icatiom 1. Certification }lith Respect to Citatian 

### at Data (£fA Fcr111851\)...29). [If fIIlt ex_ted by 4tI em 152.81 (b) (4)1; 2. Confidential Statell'limt of Forwia (EPA For. 8570-4); 3. Foraltator'$ Exeopticn StatlttW"lt (EPA Fora 

### 8S7U·znf 4. Fiw copies of draft labeling; 5. Three capies of any data stbritted; 6. Authorization lettel' wftere appUefble; 7. "-trices**~re** apptictblo. Si.ba:lssico of lnbeilF?l • Labeting =hould firn be $daitted fl'o the fom of draft tabels with at! awlicatlcm. fo; 

### new registration. sueh 

### draft labels fMi'/ be in the fon!! of typcd label tart 

### on a..s x 11 fncb pq»r 

### or a..x-h4' of the**~** l&bel. If prepared as a IlIOCkl.4l, It should be com:tru:ted in sud! • ..., _ to facilitate stonee in an 8.5 It 11 inch file. Kocklp labets significantly

.. Her tlun 8.5 x 11 it'\ItIM:I. -should be IiICWthd on 8.5 x 11 ild p:eper for .IIfJbcIisllion. $tbBil$ico of Dat-a • nata subuitted in s.upport of this ...,tiarticnrwat he sWaitted in**~** with Pit Notice 36·5, 

## SPECIfIC INSTRUCTIONS: Plooee resd the imtructicm lhttl!ld bel"" hefMlt CCII!ptetfne this application. Finn**determir~** the type of registration action, 

### tlated in Block A# fer whim yw are subafttil'l9 this IIflPllcation. For apptiClltioos. st.bnltted in eonnectlon wtth If(!tI ft09i&tratiot'lllllCticm, Seeticnr.**l~** Ill, and IV _t be toIiPleted by the appl icant. For appllcatioos. IIl.bmlttod in CCl"l'lGCtion 'trith fiIIIi!tlded resbtration actions, .--bDis.sioos., notltlc;ltiOl'1$, reregistrations, etc., Sectioos. I, ii, and IV RUSt be**~e«:d** by tM liIf'Plieam:. 

# •

Btock A • Check the &ppf'cpript\! action for Wiich you lIN**~ttins** tfIIis fctIL 

### SECTION I • This llcctiro a.mt be cospleted, .u**~iahlel** fer aU NOfstratJon a.t:ti(ll'$. 1.**~/praiJet** IWiI!IOOr • It'l$ert yew'**~~,** if OJ'II! bas been .!Ii&IdQmlld by £PA. rhi!i.**~** f!iI'.f'j hllve boon nuf1:jOed to you as a basfc**r~il>trllllt**.. ill dbtribotor. or ..**./IIi1lt$teblf~~** If your**~t** is I"t:gistered, 1l'l1.ltrt the Pn:duet 

# ........ 2. £Ph Produet**~** • If knotm, fill in tM I"IIBIWl 2M PM**~** of the**EPA"~~.** 3.**I'~** Cl_ifiCQticn • 3plcify the**~** el_tficsdcn of tbh.**~t.** 4. prcd!Jc:t IhI5e • Enter the c{)I'IIf)lete prod.tt:t**~** of this pes:Ueide d it will**~** en the Iil!beL The**~** IWIIt be specific to this pt'otruet only. D!4'iieathm. ot rs1iIIU is Mt: pmwttted**~ ~t.s**  of the**HIl!Ie~.** IX! not hv;lll!ie 

### tnt Iward I"dIe or cOillpMy liM _'snetlons. 5.

# =- end**~** of Appticmrt:

- The I1MIIe of the tina or peNlOn;and

## wreu**~** in**~** appHC4ticn is the ptffM or flMl'l 

### to whiOS the- registration 

### witt be hs.utd. If 'fO'.J l'WlI! mint in bfttf of**~** pcrty, you lIIWt stbait 

### mrthodviHon frOOl that perty tQ m::t fer thea in registration ImtteN. An ¥iQlS'lt not Ni$idil'1liii in ttw Iklitcd Stateti I!'t.Wt haw 

## an' rurthorbed agent ru:fding ih the tklited Statu; t\HIt:t 10/(' 

# mm in aU l"tIGi'iitratiQfl i!!l$ttIWZ. TM MIi!:t and ctXip1ett' mili'09 &ddress of such MI agent !!!Wt**KC~** this apptialticn. 6. Elq:edftod**R~ieu** - rUAA !!et:tioo 3 {cl 3 (in provides fot"**~iUrl** rmiew of**~iC!iti_** for**~f5ttatioo.** ¢f'**~t$** to existing registratioos. that are siallar or l'dentia;t bO**~** pe$tiddie pr«bt:t$ that ere arrontty regbtered with the EPA. In Proor f(}r YOO.J:" application to be etigibf.e frw**~t<td** null5l" you _t pNNidt: Wi wjth the EPA Reabtrbtione l\Iut:ber end prcdtict I'WI!liIe of the pr--l'rl.ICt you 1»1 it!W f#- -sf.Hu to rw fdentfut to 'fOUl"**~t.** The predx:t !l!!!J$t I» si#!iiar or identical in bQth f6hWI&tion and Ibled 1J$d. 

### §ECTXOH II

- fhis section IlUSt I» completed fPr aU applfcati_**~t:t.ed** to**~** ttw**~btratioo** oo!y of a ClJil'"rently registc-rW pnxIut;:t**~t).** for &**l"~iMion** in**~** til' an**~** lort1:cf', (Of" MtificatiOf:l!l to the 

### MoocY# Ita" tl'l¢ submJsslon of fiMI pi"lnted 

### tabet inq, for reregistr'8tion and fur II!rtf otlw:r ktion

# _t pertaln& to G !JW:!ffiiffc m·mh;tsr%!**~.** This section IS!l2!12 

### 2! wed 

### for. ow gpplie.tion 1« reait;traticn... 1. SUbject of 5tlbaissilln • CMt.k the applicable block end pNWid!ll the Aeenqr letter date if**~i.te.** I'nwim tI brfef expll\ll1lfltflln of the ptIif'POU{$) for the $4mihilln, weft as "'the NAff1:icn of 111 site-" pest (If' crop (specify)"; I<aaet')d the Confidential Stateeent of fomuta by•••I<;**·~Istraticn** tMariniGl"l';**~l** lab« ntNisi'cn of lIM directior;s." Attoch a St!pM'ate pep If additional spaoe is needed. 

## ,sECTION III (Packaging and Container Infonptiool

- This kctit:n _t be**~eted** for all IIflPllcatiooo subilltted In ecmectfon with nw reelst,-.tion or lflPlicehl

.... ' lb. 1. Type of l'ac:k.l!Gine· Che<:k tM**~Iate** block if

### Y'M' product trill be I

........ in. indicated pod:.aging types. h-dicate the size of tJa. Indl'liul pocltets 

## .u nwber per ntaf( eaufftlB". 2. Typo of

....

### n tcntaintw •**indie.t~** t)'pe of cantainw in tAidt prdIt;t

### win

..**~.** 3. lceaticn of IIet Contents

- Specify the net**~** of aU f'VltlIil eont.inma fc¢- your" pn:x:b;:t. 4. Si•• ) of Retaf( OIIntainer

- $p$eify the net contenta of aU retail Containers -fur )'11M"' pnldJct. 5. t.oclrtlcn of UIe Dlrectiona • Irdlcate the lotaticn of tbe 

### we direetiORC for your pnxIct. 6. IIW!ncr inotAidtot

... f. _Hhwd

_ 

### JIII"OIfutt • Indicate tM**~** prdId: lebd ia Iltt1diled 'to ru..il erotalMl". "io • •• •• 

# ... ... .. "

# ..**S~** 

## ry**(t~Ct** 

## POintl**~** This section

... t be c:apteted for .U apptfc:etiGnlll: for Registration actlcnr., i.e., 

### new ts r*lis Mlti&n, rHlJ.:aihion,

___too,1< rereaiatratfrn.. etc. 1·5. S.lf·expt_tory.

6. EPA OM Only. 

### •••• 

### •• 

## • • 

## •• • •• 

### ••• 

### •• • ••• 

# · .. "" 

# ... .. , 

# 97

# •

• PREpTM 4 'PLANT REGULATOR FOR COTTON FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. NOT FOR RESIDENTIAL USE. ACTIVE INGREDIENT: 

### Ethephon [(2-Chloroethyl) phosphonic aeid[" 39.9% INERT INGREDIENTS: .......................•............................... 60.1

### % "ThIs product contains 4 pounds elhephon per gallon. EPA Reg. No. 264-380 EPA Est. No. 264--PA-01


## KEEP OUT OF REACH OF CHILDREN DANGER PELIGRO

PRECAUCION AL USUARIO;-SI listed no 199 ingles, nQ 1.1GB E1ste**prodYGtO-hasta-que-ta4mom:taGi~a** 

### etiquela Ie haya siOO-&xpliGado-ampiiameRt9, 

### +RANSLA+ION-W-T.HE-US£R:-lt-yoU--Gannot.+eaQ...€RglisR-dQ-OOt-USe-this-produGt-umi\..Ute.-labal-has.Ge9R**1u~/aiooQ.jQ.l'OU.** 

### STATEMENT OF PRACTICAL TREATMENT 

### IF IN EVES: Hold eye/ids open and flush with a steady, gentle stream ofwaterforat least 15 minutes. GET MEDICALATTENTION, PREFERABLY AN OPHTHALMOLOGIST.

FOR ADDITIONAL PRECAUTIONARY STATEMENTS: See Inside Label


### For PRODUCT.!.!..S..E /nformalion Call 1-800-334-9745 For EMERGENCY Information

### QNlY Ca/124 Hours A Day 1-800-334-7577

The use 01 this product for a variety of plant growth regulation uses Is covered by United Slales and foreign patents Including U.S. Patents 3,879,188 and 4,240,8t9. No license is granted to use this product In countries other than the United States or for any use not contempla!ed by this label. Uabilily for patent infringement may result from use orsale of this product outside the United States. Ahone-Poulenc Ag Company Posl Office Box 12014, 2 T.W. Alexander Drive Research Triangle Park, NorthCarolina 27709 PREP is a frademark of Ahone-Poulenc. 

### MADE IN U.S.A.



# 98

### PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS Corrosive. Causes eye damage and skin irritation. Do not get in eyes, on skin, oron clothing.**W-ea~Qles-or** 

### faGe-SRield and**rubbQ~QlI&s** 

### when haRdling. 

### Harmful or fatal if

### swallowed. Avoid contamination 01 food, STATEMENT OF PRACTICAL TREATMENT 

### IF ON SKIN: Immediatelywash 

### with plenty of soap and water. Remave-oontamiflateEi-e1ethifl§-ElflHhoes.-Wash clothing separately-befme-r{HJ5e; IF SWALLOWED: Do not induce vomiting. Promptly drink a large quantity of milk, egg whites, gelatin solution 

### or if

### these are not available, drink large quantities ofwater. Avoid alcohol. Call a physician immediately. IF INHALED: Remove victim to fresh air. If not breathing, give artificial respiration. Administer oxygen il 

# e necessary. GET MEDICALATTENTION.



# • NOTE TO PHYSICIAN 

### No specific antidote Is available. All treatments should be based on obselVed signs and symptoms of distress in the patient. Overexposure to materials otherthan this product may have occurred. Victims of severe overexposure, by inhalation, should be kept under medical observation for up to 72 hoursfor delayed onset of pulmonary edema. In avictim of overexposure by ingestion, careful gastric lavage is required duetothe possibitity of stomach or esophogeal perforation. This material is an acid, but the use of alkaline substances to neutralize it is contraindicated. ENVIRONMENTAL HAZARDS 

### Avoid spray driftto nearby crops as this product may cause temporary modifications in plant growth. Do not contaminate water used for irrigation or domestic purposes
. Forterrestrial uses, do not apply directly to water, orto areas where surface wateris present orto intertidal areas below the mean high water mark. Do not contaminate waterwhen disposing of equipment washwaters, Do notexceed the rate of 

### PREpThl per acre peryear recommended on this label. DIRECTIONS FOR USE IT ISA VIOLATION OF FEDERAL LAW TO USE THIS PRODUCT IN A MANNER INCONSISTENTWITH ITS LABELING.

GENERAL INFORMATION 

### Afoliar spray of PREPTM 4 Plant Regulator will accelerate opening of mature unopened cotton bolls and enhance defoliation which can result in earlier halVest wilh an increased recoverable yield. PREpnt 4 Plant Regulator treatment allows increased efficiency from a once-over harvest. Some premature drop of small, immature bolls may be associated with treatment. 

### Do not apply before sUflicient, mature, unopened bolls have developed to produce the desired yield of eOlian.


# 99

# •



# • A bol! is mature when it is too hard to 

### be dented when squeezed between thumb and fingers, too hard to be sliced 

### with 

## a sharp knife, and when the seed coat becomes light brown in color. For best results. thorough and unifonn spray coverage is required. 11 is essential that the bolls are contacted by 

### the sprayto obtain optimum bol! opening. Observe treated fields closely. HalVest at optimun bol! opening and defoliation, generally 141021 daysafter treatment. Sustained cold weatherwith average day and night temperatures of 65"F orlower after treatmentwith PREpTM 4 Plant Regulator

### will delay the boll opening response. DO NOTAPPLY PREP'" 4 PLANT REGULATOR IF RAIN IS EXPECTED WITHIN 6TO 8 HOURS. Rainfall within 6to 8 hours of application may reduce product performance. Certified cotton seed growers should observe boll and seed maturity before treatment with PREpnt 4 Plant Regulator. Bolls not completely mature might open with treatment of PREprn 4 Plant Regulator giving lower quality seed. Spray deposits of PREprn 4 Plant Regulator, when lefton aircraft acrylic plastictype windshields for longerthan 1 hour, may reactwIth this materIal, fonning an opaque film or spots on the surface which cannot be removed by washing with water or any othercleaner. Rinse windshields with water immedIately after each tankload of PREflTM 4 Plant Regulator has been applied. Thoroughly rinse the aircraft with clean waterafter each day PREpm4 Plant Regulator is applied. PREprn 4 Plant Regulator may atso affect certain paints, and if accidental deposits on painted objects such as cars, trucks, agricultural equipment, etc. occurs, these objects should be rinsed with water as soon as possIble (within 1 hour) to prevent permanent staining ofthe painted surface. SPRAY PREPARATION Add 112 to 3/4 of the required amount ofwater to the spray tank. Start agitation. Add the required amount of PREPTM 4 Plant RegUlator, and the remaining amountofwater. Prepare only as much spray solution as can be used on the day of mixing. Do not allow spray solution to stand ovemight. Do not spill the concentrated product on spray equipment, or any airplane parts. ANY SPILLS SHOULD BE RINSED IMMEDIATELY WITH PLENTY OF WATER. Usa of a nurse tank is highly recommended for avoiding possible spills of concentrated formulation on spray equipmentorany airplane parts. EQUIPMENT CLEANING Because of the acidic nature ofthis product, prolonged exposure to spray deposit will damage acryUc plastiCS, certain paints, and metals. Rinse thoroughly with a detergent and water aU exposed acrylic plastic-type materials (e.g., aircraftwindshIelds), and painted surfaces within an hourafter exposure to spray deposits. At the end of each day. rinse thoroughly with a detergent and waterall the metal parts ofthe aircraft and the associated spray equipment exposed to the spray deposits.



# 100

# •

• BOLL**OeE~ltlG** Bates 

### For Boll Opening CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 5·7 DAYS AFTER PREpTM 4 

### OF PREP'"4 GALJACBE TREATMENT QUARTS/ACRE TREATS GROUND AIR Hot and 

### dry aO'F orhigher 

### 1.0 (1.0 Iba.f.) 

### 4Acres 15

### to 50 2 

### to 5· 

### Drywith 

### temperature 1.5 (1.5 Iba.i.) 2.5 Acres 

### 15 

### to 50 2105* 

### 7S'FtoOO'F 

### Cool but higherthan 6S'F 2.0 (2.0 Ib a.l.) 2 Acres 

### 15 

### to 50 2 

### to 5* Rank coHon 

### 2.0 (2.0 Ib a.i.) 2 Acres 

### 25 to 

### 50 5 *NOTE: ForCalifornia and Arizona use avolume of no less than 5 gallons peracre 

### foraerial applications Time of Application (Boll Opening) 

### Apply when there are sufficient mature unopened bolls to produce the desired yield, but no later than when 60% 

### ofthe bolls are opened (see Genera! Information section on howto test for

### boll maturity). Do not tank mix PREPTh1 4 Plant Regulatorwith a desiccant 

### ifthe coHon 

### is to be spindle harvested. 

### eBECONDITIONING FOR DEFOLIATION Rates FOr preconditioning For Defoliation


### CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 5-7 DAYS AFTER PREP'"4 OF PREP'"4 GALJACRE TREATMENT QUARTS/ACRE TREATS GROUND AIR Hotand dry eO'F orhigher 0.5 (0.5 Ib a.i.) 8 Acres 15 to 50 

### 2 to 5* Cool but higher than 65'and 1.0 Q.O 

### Ib aj.) 

### 4 Acres 15 to 50 2t05* also for rank colton ·NOTE: ForCaUlomia and Arizona use a volume of no lessthan 5 gallons per acre foraerial applications. Time of Application 

### (Preconditioning) Apply PAEpru 4 

### to 7 

### days prior to application of defoliant ortank mixed with the defoliant (see section on Compatibility). Do not tank mix PREpru 

### 4 with desiccants unless plant desiccation is required. Pre·treatment With Defoliants prlQr to 

### PREpru 4 Plant 

### Regulator Treatment 

### Ifthe cotton is overly rank orlaying down in the middles and good spray coverage ofthe bollswith PREpTM 4 Plant Regulalor Is difficult, a pretreatment with defoliants will be 

### useful to Improve boll coverage wilh PREpn.! 4 Planl Regulator, Use dosage rates of PREpn.! 4 Plant Regulator recommended for boll opening. Read and observe aU appropriate label use directions and precautions for the deloHant used. Do not use a defoliant before Ihere are sufficient mature unopened bolls to produce the desired yield (see General Information section on how th testfor BoU Maturity). COMPATIBILITY PREP'" 4 Planl Regulaloris compalible

## w,h DEF, FOLEX, DROPP, HARVADE, METHYL PARATHION, GUTHIONAND MALATHION, and may be 

### applied in sequence oras atank mixture (DO NOTTANK MIXWITH



# 101

# •

• DEFOLIANTS OR DESICCANTS IN CALIFORNIA AND ARIZONA). In some cases slight reduction in boll opening response has been observed when tank mixes with defOliants were used. Good agitation in the spray tank is essential and atank mixture should not be allowed to stand without agitation for more than 5to 10 minutes. Read and observe all appropriate label use directions and precautions for Ihe defoliants and insecticides used. PRECAUTION: DO NOT TANK MIX PREP'"4 PLANT REGULATOR WITH DEFOLIANTS CONTAINING SODIUM CHLORATE BECAUSE THIS RESULTS IN THE FORMATION OF HYPOCHLOROUS ACIDS WHICH UPON HEATING EMITTOXIC CHLORINE FUMES. WHEN TO HARVEST: Do nol harvest cotton soonerthan 7 days after atreatmentwith PREpnt 4 Plant Regulator. Observe the treated crop and harvest when optimum boll opening has been reached. Too early harvest might reduce the full advantage ofthe treatment and too late aharvesl may result In reduced quality and loss of lint which will drop from the plant. USE PRECAUTIONS Avoid spray driftto nearby crops as this product will cause modifications in plant growth. Plant injury or reduced yields will result. Do not plant anothercrop within 30 days aftertreatment. Mix only the amount ofsprayyou expectto use each day. Do not allow mixed solution to stand overnight.
STORAGE AND DISPOSAL STORAGE Do not contaminale water, food, orfeed by storage ordisposal. PESTICIDE DISPOSAL Pesticidewastes are acutely hazardous. Improperdisposal of excess pesticide, spray mixture, orrinsate is a violation of lederallaw. Ifthese wastes cannot be 

### disposed of by use according to label instructions, contact your State Pesticide or Environmental ControlAgency orthe Hazardous Waste representative at the nearest EPA Regional Office for guidance. CONTAINER DISPOSAL Triple rinse (or equivalent) the empty containers. Then offer for recycling or reconditioning, orpuncture and dispose of in asanitary tandfill, orby incineration orifallowed by state and local authorities, by buming. Ifcontainer is burned. stav out ofsmoke.



# 102

# •

• LIMITED WARRANTY AND DISCLAIMER The manulacturerwarrants (a) that this product conforms to the chemical description on the label; (b) that this product Is reasonably

### fit for the purposes setforth in the direclions for use when II is used In accordance with such directions; and (c) that the directions, warning and otherstatements on this label are based upon responsible experts' evaluation of reasonable tests of effectiveness, of toxicity to laboratoryanimals and to plants. and of residues on food crops and upon reports offield experience. Tests have nol been made on all varieties or in all slates or underall condilions. THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT 

### AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT EXPRESSLY EXCLUDESAND DISCLAIMSALL IMPLIEDWARRANTIES OF MERCHANTABILITYOR FITNESS FOR A PARTICULAR PURPOSE. THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENTWITH THE LABEL DIRECTIONS, WARNINGS OR CAUTIONS. BUYER'S EXCLUSIVE REMEDYAND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT,WHETHER OR NOT BASED IN CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR OTHERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTION, TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE PRICE FOR, THE OUANTITYOF PRODUCT WITH RESPECTTO WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT

.

Rh6ne-Poulenc Ag Company P.O. Box t2014, 2 T.W. Alexander Drive Research Triangle Park, North CaroUna 

### 2n09 PREP is atrademark of RHONE-POUlENC. PREpT"l 4 Plant RegUlator for Collon (MASTER) Notification 619193.



# 103

# •

• PREpTM 4 PLANT REGULATOR FOR COTTON FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. NOT FOR RESIDENTIAL USE. ACTIVE INGREDIENT: 

### Elhephon [(2-Chloroethyl) phosphonic acid]- 39.9% INERT INGREDIENTS:

....................................................... 60.1% -This product contains 4 pounds ethephon per gallon. 

### EPA Reg. No. 264-380


## KEEP OUT OF REACH OF CHILDREN DANGER PELIGRO

etlquata Ie haya sido explicado-ampUameme. :rRANSLATION TO mE USER;-U-yOO-GaflAOt..fead-E+lglisR-GO-AOt use this produGt-VRtMhe label-has-been lully explained to you, 

### STATEMENT OF PRACTICAL TREATMENT IF IN EYES: Hold eyelids open and flush with a steady, gentle slream ofwater for at least 15 minutes. GET 

### MEDICAL ATTENTION. PREFERABLY AN OPHTHALMOLOGIST.

FOR ADDITIONAL PRECAUTIONARY STATEMENTS: See Inside Label


### For PRODUCT!J..S..E Information Call1·aOQ-334·9745 For EMERGENCY Information 

### oo.LY Call 24 Hours A Day 1·800·334·7577

The use of this product lora variety of plant growth regulation uses is covered by United States and larelgn patents including U,S, Patents 3,879.188 and 4.24O.8t9. No license is granled to use tllis product In countries other than the United States or tor any use not contemplated bythis label. Uabillty tor patent infringement may resuk from use or sale of this product outside the United States. Rhone-Poulenc Ag Company Post Office Box 12014, 2 T.W. Alexander Drive Research Triangle Park, North Carolina 

### 2n09 PREP is a trademark of Rhone-Poulenc. 

### MADE IN U.S.A.



# 104

### PRECAUTIONARY' STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS Corrosive, Causes eye damage and skin irritation. Do not get in eyes, on skin, oron clothing.**~ 1aG&-Shi~O'lQS**  

### wneR-RaAdUAg. Harmful orfatal 

### if swallowed. Avoid contamination of food. 

### STATEMENT OF PRACTICAL TREATMENT 

### IFON SKIN: Immediately wash with plentyofsoap and water, Remove eoAtamiRatet:k*ethiA§-and shoes. 

### lNaSR clothing separately bofore reus&: IF SWALLOWED: Do not induce**vom~ing.** 

### Promptlydrink a large quantity of milk, egg whites, gelatin solution 

### orifthese are not available, drink large quantities ofwater. Avoid alcohol. Call a physician immediately. 

### IF INHALED: Remove victim to fresh air. If not breathing, give artificial respiration. Administeroxygen if 

# tit necessary. GETMEO!CALATIENT!ON.



# • NOTE TO PHYSICIAN No 

### specilic antidote Is available. All treatments should be based on observed signs and symptoms ofdistress in the patient. Overexposure to materials other than this product may have occurred. Victims ofsevere overexposure, by inhalation, should be kept under medical obselValion for up to 72 hoursfor delayed onset of pulmonary edema. In a victim ofoverexposure by ingestion, careful gastric lavage is required due to the possibility ofstomach or esophageal perforation. This material is an acid, but the use of alkaline substances to neutralize it 

### is contraindicated. ENVIRONMENTAL HAZARDS 

### Avoid spraydrift to nearbycrops as this product maycause temporary modifications in plant growth. Do not contaminate water used for irrigation ordomestic purposes
. Forterrestrial uses, do not apply directly to water, orto areas where surface water is present or to intertidal areas below the mean high water mark. Do not contaminate waterwhen disposing of equipmentwashwaters. Do not exceed the rate of PREpm per acre peryear recommended on this label. DIRECTIONS FOR USE IT ISAVIOLATION OF FEDERAL LAWTO USE THIS PRODUCT IN A MANNER INCONSISTENTWITH ITS LABELING, Mixers, /Qadimi aR4applicakJ.r.s must wear-a-lu,ll facs shiBId, long trouseR;, kmg Sls81!8fishi#rgloWiJSr8r/{j.bootS-to aw#d-as 

### much**sk~~~/e..**



### GENERAL INFORMATION 

### Afoliarspray of PREpm 4 Plant Regulatorwill accelerate opening of mature unopened cotton bolls and enhance defoliation which can result in earlierharvest with an increased recoverable yield. PREpTM 4 Plant Regulator treatment allows increased efficiency from a once-over harvest. Some premature drop of small, immature bolls may be 

### associated with treatment Do not apply before sufficient. mature, unopened bolls have developed to produce the desired yield of callan.


# 105

# •

• A boll is mature 

### when Ii is 

### 100 hard to be denied

### when squeezed between thumb and fingers. 

### 100 hard to be sliced with 

### a sharp knife. and when the seed coat becomes light brown in color. Forbest results, thorough and uniform spray coverage is required. [t 

### is essentialthat the bolls afe 

### contacted by the sprayto obtain optimum boll opening. Observetreated fields closely. Harvest at oplimun boll opening and defoliation, generally 14 to 21 days after treatment. Sustained cold weatherwith average dayand night temperatures of65°F 

### or [owerafter treatmentwith PREPTM 4 

### Plant Regulatorwil! delaythe boll opening response. DO NOTAPPLY PREP'"4 PLANT REGULATOR [F RA[N [S EXPECTED WITH[N 6TO BHOURS. Rainfall within 610 8 hours of application may reduce product performance. Certified cotton seed growers should observe bon and seed maturity before treatment with PREpTM 4 Plant Regulator. Bolls notcompletely mature might open with freatment of PREprn 4 Plant Regulator giving [ower quality seed. Spray deposits of PREPTM 4 Plant Regulator, when left on aircraft acrylic plastic type windshields for longer than 1 hour, may react with this material, forming an opaque film orspots on the surface which cannot be removed by washing with wateror any othercleaner. Rinse windshields with water immediately aftereach tankfoad of PREflThl 4 Plant Regu[ator has been appUed. Thoroughly rinse the aircraft with clean water aftereach day PREpn.! 4 Plant Regu[ator is applied. PREPTM 4 Plant Regu[ator may also affecfcertain paints, and 

### ifaccidental deposits on painted objects such as cars, trucks, agricultura[ equipment, etc. occurs, these objects should be rinsed with water as soon as possible (within 1 hour) to prevent permanent staining ofthe painted surface. SPRAY PREPARATION Add 

### 112 to 3/4 ofthe required amount ofwater to the spray tank. Start agitation. Add the required amount of PREpTM 4 Plant Regulator, and the remaining amount ofwater. Prepare only as much spray solution as can be used on the day of mixing. Do notallow spray solution to stand overnight. Do not spill the concentrated product on spray equipment, or any airplane parts. ANY SPILLS SHOULD BE R[NSED [MMED[ATELYWrrH PLENTY OF WATER. Use ofa nurse tank is highly recommended for avoiding possible spins ofconcentrated formulation on spray equipment or any airplane parts

. EQUIPMENT CLEANING Because ofthe acidic nature ofthis product, prolonged exposure to spray deposit will damage acrylic plastics. certain paints, and metals. Rinse thoroughlywith adetergentand water all exposed aCrylic plastic-type materials (e.g., aircratt wlndshie[ds), and painted surfaces within an hour after exposure to spray deposits. At the end of each day, rinse thoroughly with adetergent and water all the melal parts ofthe aircraft and the associated spray equipment exposed to the spray deposits.



# 106

# 8

8 aQLL**QeENI~G** Rates 

### For Boll Opening CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 5-7 DAYS AFTER PREprn4 OF PREP'" 4 GAL.iACBE TREATMENT QUARTS/ACRE TREATS GROUND AIR 

### Hot and dry eO'F or higher 1.0 (1.0 Ib aj.) 

### 4 Acres t5 to 

### 50 

### 2 to 

### 5" Drywith 

### temperature 1.5 (1.5 Ib aj.) 2.5 Acres 

### 15 

### to 50 2to 5" 

### 7S'Fto80'F Cool but higher than 6S'F 2.0 (2.0 Ib a.i.) 2 Acres 

### 15 

### to 50 

### 2 to 

### 5· Rank cotton 2.0 (2.0 Ib a.i.) 2 Acres 

### 25 to 

### 50 

### 5 "NOTE: For California and Arizona use avolume of no less than 5 gallons per acre for aerial applications 

### Time of Application (BoU Opening) Apply when there are sufficient mature unopened bolls to produce the desired yield, but no later than when 60% ofthe bolls are opened {see General Information section on how to test for boll maturity}. Do nottank mix PREprn 4 Plant Regulator with a desiccant 

### if the cotton is to be spindle harvested. 

### PRECQNDITIQNING FQR DEFQLIATION 

### Rates For preconditioning For Defoliation
CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 5-7 DAYS AFTER PREP'"4 OF PREP'"4 GAL.!ACRE TREATMENT QUARTS/ACRE TREATS GROUND AIR 

### Hot and dry aO"F or higher 0.5 (0.5 Ib a.i.) 

### 8 Acres 15to 50 

### 2 to 5' Cool but higherthan 65'and 1.0 (1.0 Ib a.i.) 

### 4 Acres 

### 15 to 

### 50 2 to 5' 

### also for rank cotton -NOTE: For California and Arizona use avolume of no lessthan 5 gallons peracre for aerial applications. 

### Time of Application (Preconditioning) Apply PREptM 4 

### to 7 days priorto application of defoliant ortank mixed with the defoUant (see section on 

### Compatibility). Do not tank mix PREpn.! 4with desiccants unless plant desiccation is required. 

### Pre-treatment With Defoliants Prior to 

### pRepm 4 plant Regulator Treatment [fthe cotton 

### is overly rank or laying down in the middles and good spraycoverage ofthe bolts with PREpm 4 Plant 

### Regulator is difficult. a pre1reatmentwith defoliants will 

### be usefulto improve 

### bon coverage with PREpTM 4 Plant Regulator. Use dosage rates of PREpThI 4 Plant Regulator recommended for boll opening. Read and observe all appropriate label use directions and precautions for the defoliant used. Do not use a defoliant beiore there are sufficient mature unopened bolls 10 produce the desired yield (see General Information section on how th test for Boll Maturity). COMPATIBILITY PREpThl 

### 4 Plant Regulator is compatible with DEF, FOLEX, DROPP, HARVADE, METHYL PARATHION, GUTHION AND MALATHION, and may be

### applied in sequence oras atank mixture (DO NOT TANK MIXWITH



# 107

# •

• DEFOLtANTS OR DEStCCANTS IN CALIFORNIA AND ARIZONA). In some cases slight reduction in boll opening response has been observed when tank mixes with defoliants were used. Good agitation in the spray tank is essential and atank mixture should not be allowed to stand without agitationfor more than 5 to 10 minutes, Read and observe all appropriate label use directions and precautions forthe defoliants and insecticides used. PRECAUTION: 00 NOT TANK MIX PREP'"4 PLANT REGULATOR WITH DEFOLIANTS CONTAINING SODIUM CHLORATE BECAUSE THIS RESULTS IN THE FORMATION OF HYPOCHLOROUS ACIDS WHICH UPON HEATING EMIT TOXIC CHLORINE FUMES. 

### WHEN TO HARVEST: Do not harvest cotton soonerthan 7 days afteratreatmentwith PREprM 4 Plant Regulator. Observe the treated crop and harvest when optimum boll opening has been reached. Too early harvest might reduce the full advantage ofthe treatment and too late a harvest may result in reduced qualityand loss of Unt which will drop from the plant. USE PRECAUTIONS 

### Avoid spraydrift to nearbycrops as this product will cause modifications in plant growth. Plant injury or reduced yields will result. Do not plant anothercrop within 30 days aftertreatment. Mix only the amount ofspray you expectto use each day. Do not allow mixed solution to stand overnight.

STORAGE AND DISPOSAL STORAGE 

### Do notcontaminate water, food, or feed by storage ordisposal. PESTICIDE DISPOSAL 

### Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture. or rinsate is a violation offederal law. Ifthese wastes cannot be disposed ot by use according to label instructions. contact your State Pesticide or Environmental Control Agency or the Hazardous Waste representative at the nearest EPA Regional Office forguidance. CONTAINER DISPOSAL 

### Triple rinse (or equivalent) the empty containers. Then offerfor recycling or reconditioning, or puncture and dispose of in asanitary landfill, orby incineration or ifallowed by state and local authorities, by 

### buming, Ifcontainer is burned, stay out of smoke.



# 108

# ,



# •

• LIMITED WARRANTY AND DISCLAIMER The 

### manufacturerwarrants (a) that this product conforms to the chemical description on the label; (b) that this 

### product is reasonably fit 

### forthe purposes set forth in the directions for use when 

### it is used in accordance with such directions; and (c) that the directions, warning and otherstatements on this label are based upon responsible experts' evaluation 01 reasonable tests 01 effectiveness, oftoxicity to laboratory animals and to plants, and 01 residues on food crops and upon reports offield experience. Tests have not been made on all varieties or in all states orunderall conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT AUTHORIZE ANYAGENT OR REPRESENTATIVE TO MAKE, ANY OTHERWARRANTIES, EXPRESS OR IMPLIED, AND IT EXPRESSLY EXCLUDESAND DISCLAIMS ALL IMPLIEDWARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OFTHIS PRODUCT IN ANY MANNERWHICH IS INCONSISTENTWITH THE LABEL DIRECTIONS, WARNINGS OR CAUTIONS. BUYER'S EXCLUSIVE REMEDYAND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER OR NOT BASED IN CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR OTHERWISE SHALL BE LIMITED. AT THE MANUFACTURER'S OPTION, TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE PRICE FOR, THE QUANTITY OF PRODUCTWITH RESPECTTO WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECTOR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT

.

RhOne-Poulenc Ag Company P.O. Box 12014,2 T.W. Alexander Drive Research Triangle Park, North Carolina 27709 PREP is atrademark 01 RHONE·POULENC, PREP'" 4 Plant Regulator tor Cotton (MASTER) Notllicalion 619/93.



# 109

# •

• UNITED STATES ENVIRONMENTAL PROTECTION AGENCY Office of Pesticide programs Registration Division

Warren A. Davis RHONE-POULENC AG COMPANY BOX 12014 

## RESEARCH TRIANGLE PARK NC 27709

Comment for: EPA Reg Nr.264-380 PREP PLANT REGULATOR FOR COTTON The following specific comments pertain to your WPS labeling submission concerning the product cited above:
Correct the typographical errors circled on your proposed label

.



# 110**.~-~.-** ... 

### • PI

.." on reverSf!1 before 01, IOMRN •. 

## "'.".0' (A)

# aEPA I I**nA,~"** 

## Registration 

## lopp I Oflioo 

# I- Washington, DC 20460 "g

... 

# 188592 Application for Pesticide: I- 

## '-


## "

## l't~Pe'les~~~o,;~ 

# /3. I if 

# 14. CompanylProc!uct (Nama) 

## IPM. 

# ONona 

# o AaSlriclod 

## PREP 4 Plant Regulator for 

## cotton 22 

# 15. Nama andAddress 01 

# -, Ifb)(i), my !rodUC1 is

# Si~i:;r or

# idQnlica~**~ilh** .**~3(C\:31** (0: 

### EPA Rag. No. 

# o Chocl< ifthis is

### a nowaddro$$
, D. 

# ..". nI 

### I- Amendment- Explain below**~_ :a_~.I~** -,in responso to 

# -=: Aosubmission in response to Agency letterdatod 

### I-

## ~ Noulication· E:qllain below.

. 

### I- "MuToo·Application. Other

-explain below. Usc additional pag6{s) il n&OOsury. (For IIOCrion 1and Soetion ILl


### Notification: 

## (PR Notice 93-3) 

## labeling statement

# prohi:ii~**~** 

## to water. f} Section Itl 

# .".,..



# .M,to"" Thl. "'"".01WUI •• d1",



# , . 

# ,

# I ,<.**,~ol** 

# 8 Yes· 

# I-/ Y.'

# ~~:~ .• No No

## ~jN. Glass**N~:.~r** No. po< Papar 

# .:**~a~~WgI.** 011", • ClIrtlflcatlon

### mustM contamar cont:lInor 

# ;":' 

# , 

# ..,. 13. Location 01 Net Conlenlsinformalion 

### ,"**S1'~'1** 

### 01 R"" 

# El**,'~""** .. 

### ••••



# o""'" n Co 

## • 

# . • 

# ,S.

, Whioh "'bel ITo**Pro"'~**

# ~ Dru. 

# • , :::

# . I 

### • 

# :. • I 1 , ..b. N,me 

## In

.. , No:

## ~ Warren Davis 

## Isenior Registration 

## Manager 919-5<w-aa'9 

# ...- is. r !C(lrtify that the statements 1 haYo made on \his form and all alUlchm9flts thOfOto are true, acrurate and completo. Iacknowledge that any knowingly false ormisleading statement may be punIshable by fino orimprisonment or (Stamped) bothunderappHcablelaw. 

# I'· 1, 

# /3 T,'.

# .,(;{/~ 

# 1- {), , 

## Reqi'+ ,+', M.n,npr**I"~** 

# IS. 

# 0". Warren Davis June 

### 9. 1993 

## 111
t'A .-orm**II~/U'** WOlI. EPA 

## H" copy**YO'~W** " <Dpy

# PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS pAPERWORK REDUCTION ACT 

## NOTICE: Public reportil'lD burden for-thiS, collection of infotfMtion

### f.>~.timated to average 0.85 hour per response, including time for reviewing instructionlt, searching existing data SOW-COB, gathering and maintaining the data needed, and cOIIpleting and reviewing thl! collection of in(ofll\Qtion. Send COImIOOts regarding the burden e&til1lllte or tInY other IlSpect of this colle<:tion of information, including suggeStions for reducing this burden, to Chief, Information Policy Branch, PH-223, U.S. EnvirOMJental Protection Ageney, 401 MStreet, 5\1, Uashington, OC 2046tli and to the 

### Office'of Information and Regulatory Affairs, Office of Mariagemont and 

### Budget, Uashington, DC 20503. INSTRUCTIONS: This form is to be used for all applications for 

### nw registration, end use reregistration,**~t,** resu!::missfon, to applications for notifications, final printed labeling, reregistration, etc. ln ordltr to prOCI!:;s an application for a 

### new registretion sul::l'flitted on this form, the following material IIJJSt**acc~** the application: 1. Certification with Respect to Citation of Ollto (EPA Form 8570·29). [If not exO!1lCpted by 40 CFR 152.81 (b) [4)); 2. Confidential Statement of FOnP.Ila (EPA Form**857t1~4);** 3. Forll1Jlator's Excwption StatCltltnt (EPA Form 8570·27);' 4. Five copies of draft labeling; 5. Three copies of any data st.bnitted; 6. Authorization letter where applicable; 7. Matrices khere applicllble. Subnisslon of Lobeling

- Ll\beling should first be submitted in the form of draft labels with all applicat;lons for new registration. Such draft label:; may be in the form of typed label text on 8.5 ;'It 1l inch P'lper or II mockup of the prop<lslld label. If prepared as a 1WC1tl:9, it should be construc:ted in such a way as to facilitat&**stora~'in** 

### an 8.5 x 11 inch file. Mockup labels significantly smaller than 8.5 x 11 inches should be mounted on 8.5 x 11 inch paper for subnission. SUaission of Data

- Data stb!!itted in**s~rt** of this application Il'USt be submitted in accordance wfth PR Notice 86·5. 

## SPECIFIC INSTRUCTIONS: Please read the instructions listed below before cOll'pleting this application. first • determine the type of registration action, listed in Block A, for which you are submitting this application. For

_ applications submitted in connection with Hew Registratlon 

### actions, Sectiorn'l I, III, aOO IV I!tJst be cowpleted by the applicant. For applications submitted in connection wjth amended registration actions, resubmi:;sions, notifications, reregistrations, etc., Sections I, TI, and IV rust be cOilpleted by the applicant. Slode A

- Check the appropriate action for which you are sU:mitting this form. 

## SECTION I

- This section Il'U$t be cooplete<:i, as applicable, fQr all registration actions. 1. CoIIpany/Prcxb::t Insert your 

### co.pony 1fUIther, if 

### ono: has been assigned by EPA. This m.nber may hive bHn assigned to you as a b.!Islc 4 distributor, or as an establishment. If your product is registered, insert the Pn:dJet 

### Nu.ber. ; 2. EPA Product the I'InII» and PM nutber of the EPA Product Manager. 3. classification of this prc4Jct. 4. of this pesticide as it will appeor on the label. The name**~t** be specific to of l"IIlI!'IeS is not permitted IimOI"IO prodUcts of the S/IIM**conpany~'"** 00 not**incl~** any brand name or company 5. Matle ard Address ,of Applfcoot

- The naHiC" of the finn or person, and address shown in your application,l$ the p4r$oo or fil'1ll to whom the registration will be issued. If you are acting- in behalf of another party, you Jl)Js.t sl.bnit iWthori:l:ation from that party to act for them in registration matters. An applicant not residing in the United States must have 

### an authorized agent residing in the United States to act for them in all registration matters. The**~** ond complete 'mailing address of such 

### an agent _t**acc~** this applic3tion. 6.**~ited** Review

- FlFRA section 3 (c) 3 [8) provides for expedited review of applications ior regIstration, or,amendments to cxisting tegistrations, that are similar or identical to other pesticide products that are currently registered with

_ the EPA. IfIIto.rder for your application to be eligible for expedited**revi~,** you Il'Ust provide us with the,EPA**Registrati~**

..**~r** 11M p10duct rwme- of the pr<Xkx:t you believe is similar to or identiclll to your product. The product I'fJJSt be :**~imtlar** or. "fe1'tjcal in both form;lation III1d labeled uses. 

## 'mION 

# Ii

.-;his s.u:tion It'IJst be conpleted for all applicDtiorn'l sublIitted to emend the registration only of a currrotly**r~·btered pr~J**  "AmorxiMnt), for a reslJtfflission in respc:;Me to an Agency letter, for notifications to the Apncy, for the ,00000Uion of'''f'IMt!.prlnted labeling, for reregistration and for any other fiction thllt pertains to a $pe(:ifle ru-CHhteroo**~.** Thh; section is!!!ll 

### 12 

### 21! used for 4 

### new application for registration. 1. ,&bjec:t: of.\tldi,p,sicn

- Check: the npplicable block: and prOVide the Agency letter date if Appropriate. Provlde a bl"ief ••.wlanutiOl'fM'"the purpose(s) for**th~** sui:missiOfl, such liS lOthe addition of a site, past or crop (sp«;ifY)"i lfaMnd the • l"'tmfidential.Suternent of fornula by•••"; "rere-gistration subnlssion-"; gwral label revision of use directions." Attach



# ··a scp.arate<fiilgeJf additional s!)Gce is rweded. 

# :

# ..:.. 

# . .....

# :,. S'eC'PlON III I.Packaging and Container Information)

- This Sec,tion Il'USt be coopleted for all applications sul:mitted**in:C~ion** with**~** registration or applicable IIfIIOfldaents. 1. Type of Pec"bQu'G

- Checlt the appropriate block if your product will be p4Cltag&d in the indicated packaging types. lOOicate the- she of the individulll packets and flI.Jfber per retail container. 2. Type of Retail container

- Indicate type of container in which prockJct will 

### bii IIIDrketed. 3. Location of Met Ccntents

- sp.ecify the net contents of aU retail containers for your product. 4. Sixe(s) J)f'Retail Container

- speclfy the net contents of nll retail containers for your product. 5. Locution of IJI.e Dir«tione.

- Indicate the location of the use directions. for your product. 6,**~** in .bich lobel ill: affixed to pnxb:t

- IOOiclltl/ the IliIethod product label is attllched to retail container. 

## SECTION IV {Contact Point}

- This $ectiOflll'USt 00 cOll1)leted for IIll applications for Registration actions, i.e., MW products registration, resubmission, lime·too," reregistration, etc. 1-5. Self-explanatory.

6. EPA USe only. 

# 112

### ,

## .



# • LABEL INFORMATION PAGE 

# PREpTM 

# 4 PLANT REGULATOR FOR COTTON MASTER LABEL

Routing: Product Development Product Manager Others Legal State Registrations Registration Manager


# General label revisions:
• Notification 

## 6/9/93 • revised wetlands statement. 

# Rate changes for the following:

• CA restrictions: Printing Restrictions: • •••

• •••••• •••• 

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# •

• PREP"" 4 PLANT REGULATOR FOR COTTON FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. NOT FOR RESIDENTIAL USE. ACTIVE INGREDIENT: Ethephon [(2oChioroethyQ phosphonic acid}' 

### 39.9% INERTINGREOIENTS:

.._•.•...............................................•. 60.1% 

### -This product

### contains 4 pounds ethephon per gallon. EPA Reg. No. 264·380 EPA 

### Est. 

### No. 264-PA-01


## KEEP OUT OF REACH OF CHILDREN DANGER PELIGRO

PRECAUCION AL USUARtO: Si USled no 

### lee ingles, no use este producto hasla que la informacion en la eliqueta Ie haya sldo explicado ampliamenle. TRANSLATION TO THE USER: If 

### you cannot read English do not use this product until 

### the label has been 

### fully explained to you. STATEMENT OF PRACTICAL TREATMENT 

### IF IN EYES: Hold eyelids open and flush with a steady, gentle stream ofwaterforat least 15 minutes. GET MEDICALATTENTION. PREFERABLY AN OPHTHALMOLOGIST.
FOR ADDITIONAL PRECAUTIONARY STATEMENTS: See Inside Label
For PAOPUCTllS.f Information 

### Call1-aOO-334-9745 

### For EMERGENCY Infonnalion

## ONLY Call 24 Hours A Day 1-800..a34-7577

Tho usc ofthis product for a varioty of plant growth regulation USGS is covored by 

### Unitod Stalosand 10reign 

### patottts including U.S. Patents 3,879,188 and 4,240,819. No licGnse Is granted to use this product in countrios other than the UniMKf States or for any use not contemplated by this label. liability for patent Infringement may result from use orsale ofthis 

### pr.o£kJct outs:cr

.. :·: the United States. • ...: • • Rhone-Poulenc 

### Ag Company Post Office 

### Box 120t4, 2 T.W. Alexander Drive Research 

### Triangle Park, North

### CarOlina 

### 2n09 PREP 

### is a trademark of**Rhone~Poulenc.** 

### • • 

## • 

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### •••• MADE IN U.S.A. 

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• PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

### Corrosive. Causes eye damage and skin irritation. 

### Do not get in eyes, on skin, oron clothing. Weargoggles or face shield and rubber gloves when handling. Hannful orfatal If

### swallowed. Avoid contamInation offood. STATEMENT OF PRACTICAL TREATMENT 

### IF ON SKIN: Immediately wash with plenly ofsoap and waler. Remove contaminated clothing and shoes. Wash clothing separately before reuse. IF SWALLOWED: 

### Do not induce vomiting. 

### Promptly drink a large quantity of milk, egg whites, gelatin solution or

### ifthese are not available, drink large quanllties ofwater. Avoid alcohol. Call a physician Immediately. IFINHALED: Remove victim 

### to fresh air. If not breathing, give artificial respiration. Administeroxygen 

### if 

### necessary. GET MEDICAL ATIENTIDN

. NOTE TO PHYSICIAN 

### No specific antidote is available. All treatments should be 

### based on observed signs and symptoms ofdistress In the patient. Overexposure to materials otherthan this product may have occurred, Victims ofsevere overexposure, by inhalation, should be 

### kept undermedical observation for up to 72 hoursfor delayed onsetofpulmonary edema. In avictim ofoverexposure by Ingestion, careful gastric lavage is 

### required due to the possibility ofstomach oresophogeal perlorallon. This material Is an acid, but the use ofalkaline substances to neutralize it is contraindicated. ENVIRONMENTAL HAZARDS 

### Avoid spraydrift to nearbycrops as this product maycause temporary modifications in plant growth. 00 not contaminate water used for inigationordomestic purposes. Forterrestrial uses, do 

### not apply directly to water, to areas where surface water is presentorto Intertidal areas belowthe mean high water mane 00 notcontaminate waterwhen disposing of equipmentwashwaters. 

### Do not exceed the rate of PREPTM peracre peryear recommended on this label. GENERAL INFORMATION 

### Afoliar spray of PREpn.t: 4 Plant Regulatorwill accelerate opening of mature unopened cotton bolls a"qenhance defoliationwhich can resutt inearlierharvest wilh an Increased recoverable yield. PREpn.! 4 Plant Re,QJJtJtor : ••:.: treatment allows increased efficiencyfrom a once.()ver harvest. •••• : • • Some premature drop ofsmall, immature bolls may be 

### associatedwith treatment. mature, unopened bolls have developed to produce the desired yIeld of cotton. 

## •••••• • 

## •• Do not apply 

### befa,re sufficient, •• 

## •••••• •

## •••• 

## • • • 

## ••••• •••• A boll is mature when it is too hard to be 

### dented when squeezed between thumb and fingers, too**Ma:Uc~**

## be sliced • with aSharp knife, and when the seed coat becomes light brown in color. • ••: ••: 

## •• • 

## •• " 

# ... ...... Forbest results, thorough and uniform spraycoverage IS 

### required. 

## tt Is essential that the bolls are COliltaoted by ••• •• the sprayto obtain optimum boll opening. Observe treatedfields closely, Harvest at optimun boll**o~nLnQ:**

### and • defoliation, generally 14to 21 days after treatment. Sustained cold weatherwith average day and night •• temperatures of 65°F or loweraftertreatment with PREpTM 4 Plant Regulator will delaythe boll opening response.



# 115

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# • ...... _. 

### __ ........... ............. •••.......-- ..**--~-**



### DO NOTAPPLY PREP'" 4 PLANT REGULATOR IF RAIN IS EXPECTED WITHIN 6 TO 8 HOURS. Rainfall within 6to Bhours ot application may reduce product perfonnance. Certified cotton seed growers should observe boll and seed maturity before treatmentwith PREpTJ.! 4 Plant 

### Regulator. Bolls 

### not completely mature might 

### open with treatment of PREpn.c 4 Plant Regulatorgiving }ower 

### quality seed. Spray deposits of PREpi'M 4 Plant Regulator, when lefton aircraft acrylic plastic

### typewindshields for longerthan 1 

### hour, may react with this matertal, forming an opaque 111morspots on the

### surface which cannot be 

### removed by washing with

### wateroranyothercleaner. Rinse windshieldswithwater Immediatelyafter each tank/oad of PREpnt 4 Plant Regulator has been applied. Thoroughly rinse the aircraftwith clean wateraftereach day PREpm 4 Plant Regulator is applied. PREpnt 4 Plant Regulator may also affect certain paints, and 

### ifaccidental deposits on painted objects such as 

### cars, trucks, agricultural equipment, etc. 

### occurs, these objects should be 

### rinsed with wateras soon as possible (within 1

### hour) to prevent permanent staining of the painted surface. 

### SPRAY PREPARATION Add 

### 1/2

### to 314 

### ofthe required amountofwaterto the spray tank. Start agitation. Add 

### the required amountof PREpt'N 4 Plant Regulator, and the remaining amount ofwater. Prepare only as much spraysolution as can be 

### used on the day of mixing. 

### Do not allow spraysolution to stand overnight. 

### Do notspill the concenlrated product on spray equipment, orany airplane parts. 

### ANY SPILLS SHOULD BE RINSED IMMEDIATELY WITH PLENTYOF WATER. Use ofa nurse tank is highly recommended for avoiding possible spills of concentrated tormulation on spray equipment or any airplane parts. 

### EQUIPMENT CLEANING Because ofthe acidic nalure ot this product, prolonged exposure to spray depositwill 

### damage acrylic plastics, certain paints, and metals. Rinse thoroughlywith adetergent andwaterall exposed acrylic plastic-type materials (e.g., aircraft windshields), and painted surfaces wHh!e an hour

### aUerexposure to spraydeposits. Altha

### end of

### each day. 

### rinse thoroughly whh a detergent andwaterall the metal parts otthe aircraft and Ihe associated spray equipment exposed to the spray deposits

. 

### DIRECTIONS FOR USE IT ISAVIOLATION OF FEDERAL LAWTO USE THIS PRODUCT INA MANNER INCONSISTENTWITH ITS LABELING. Mixers, loadelSandapplicatorsmust weara fuJI

### face shield. 

### Jong trousers, long

### sleevedshirt, gloves, andboots to avoidas much skin andeye contactaspossible. .:. 

## • •••••• 

### Do notentertreatedlields within 24

### hours afterapplication unlessprotective clothing is worn. •••• 

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116

# 8



# 8 BOLL OeEtlltlG Rates For Boll Opening 

### CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 5-7 DAYSAFTER PREpTM 4 OF PREpTM4 

### GALIACRE 

### TREATMENT QUARTS/ACRE TREATS GROUND AIR Hot and dry80-F or higher 1.0 (1.0 Ib a.l.) 4 

### Acres 15

### to 50 

### 2to 5· Drywith temperature 

### 1.5 (1.Slb a.l.) 2.5 

### Acres 

### 15 to 50 2

### to 5- 

### 7S·Fto8Q"F Cool 

### but higherthan SS'F 

### 2.0 (2.0 iJ 

### a.i.) 2Acres 

### 15

### to 50 2 

### to 5- 

### Rank cotton 

### 2.0 (2.0 Ib a.l.) 2 Acres 

### 25 

### to 50 5 -NOTE: ForCallfomia and Arizona use avolume of no less than 5 gallons peracre foraerial applications Time of Application (Boll Opening) 

### Apply when 

### there are sufficient mature unopened bolls to produce the desired yield, 

### but no later than when 600/0 of

### the bolls are opened (see Generallnfonnation section on 

### howto testfor boll maturity). Do nottank 

### mix PREf>T1'I 4 Plant Regulatorwith adesiccant if

### the cotton Isto 

### be spindle harvested. 

### eBECOtlQITIOtlltlG FOR QEEOLIATIOtl Bates For preconditioning For DefollatlQn


### CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 5-7 DAYS AFTER PREP"" 4 OF PREpTM4 

### GALIACBE TREATMENT QUARTS/ACRE TREATS GROUND AIR Hot and dry BO"F or higher 

### 0.5 (0.5 Ib a.l.) 8 

### Acres 15

### to 50 2 

### to 5- 

### Cool 

### but higherthan 65'and 

### 1.0 (1.0 Ib a.l.) 4 Acres 

### 15 to 50 2 to 5· also for rank cotton ·NOTE: For

### Califomia and Arizona use a

### volume

### ofno 

### less1han 5

### gallons peracre for aerial applications. 

### Ilme of 

### Application (Precondftfonlng) Apply PREP"" 4to 7 days priorto application of defoliant ortank mixedwith the defoliant (see section 0lI 

### Compatibility). 

### Do not tank mix PREPnI 4with desiccants unless plant desiccation is required. .:. 

### •••••• •

### ••• • 

### ••**pre~treatmeDt** 

### With pefollants prior to PBEpTM 4 plant Regulator Treatment
.... : • • If

### the cotton Is overly rank or laying down In the middies and good 

### spray coverage ofthe bolls with PREpni 4 Plant:··: Regulator

### is diffICUlt. a pretrealmentwith defoliantswill be useful to improve boll coverage with PREr.**4:~lant** 

## ••:: Regulator. Use dosage rates of PREPTM 4 Plant Regulator recommended for boll opening. Read 

### aRa obServe**~I.** 

### • 

### appropriate label use directions and precautions forthe defoliant used. •••••• ..:• 

### •••• Do not use adefoliant before there are sufficient mature unopened bolls to produce the desired yield (see Generallnfonnation section on 

### how th testfor Boll Maturity). : •••• 

### •••• COMPATIBILITY ••• : 

### PREP""4 Plant Regulator is 

### compatible wnh DEF, FOLEX, DROPP, HARVADE, METHYL PARATHION,.· GUTHION AND MAlATHION, and may be 

### applied In sequence oras atank mixture (DO NOTTANK MIXWITH



# 117 •

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• DEFOLIANTS OR DESICCANTS IN CALIFORNIAAND ARIZONA). In some cases slight reduction In bog 

### opening response has been observed when tank mixes**w~h** 

### defoliantswere used. 

### Good agitation in the spray lank Is essential and atank mixture should not be 

### allowed to stand without agitation for more than 5to 10 minutes. Read and observe all approprfate label use directions and precautions forthe defoliants and insecticides used. PRECAUTION: DO NOTTANK MIX PREP'"4 PLANT REGULATOR WITH DEFOLIANTS CONTAINING SODIUM CHLORATE BECAUSE THIS RESULTS INTHE FORMATION OF HYPOCHLOROUSACIDS WHICH UPON HEATING EMITTOXIC CHLORINE FUMES. WHEN TO HARVEST: 

### Do not harvest cotton soonerthan 7 days afteratreatmentwith PREpn.! 4 Plant Regulator. 

### Observe the treated crop and harvestwhen optimum boll opening has been reached. Too eal1y harvest might reduce the full advantage of

### the treatment and foo late a harvest may result In reduced quality and loss of lint which 

### wig dropfrom the plant. USE PRECAUTIONS Avoid spraydrift to nearby crops as this productwill 

### cause modifications in plant growth. Plant Injuryor reduced 

### yields will 

### result

. 00 not plant anothercrop within 30 days aftertreatment. 

### Mix onlythe amount ot spray you expectto use each day. 

### Do not 

### allow mixed solulionto stand overnight.
STORAGE AND DISPOSAL STORAGE 

### Do not contaminate water. food, or feed by storage ordisposal. PESTICIDE DISPOSAL Pesticidewastes are acutely hazardous. Improperdisposal ot excess pesticide. spray mixture, orlinsate Is a violation offederal law. Ifthese wastes cannot be 

### disposed ofby use according to label instructions, contact your State Pesticide or Environmental ControlAgency orthe Hazardous Waste representative atthe nearest EPA Regional Office for guidance. CONTAINER DISPOSAL Triple rinse (orequivalent) the empty containers. Then offerfor recycling or reconditioning, orpuncture and dispose of 

### In a sanitary landfill. orby incineration orif

### allowed by

### slale and local authorities, by

### burning. ff

### container is burned stay out ofsmoke.



### • 

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118

# •

• LIMITED WARRANTY AND DISCLAIMER The manulacturerwarranls (a) Ihallhis product conlorms 10

### the chemical description on

### the label; (b) lllal this produCI 

### is reasonably

### tit lorthe purposes setforth In the directions for use when It 

### is used in accordance with such directions; and (C) thatthe direcllons, warning and olhersta1emenls on Ihis 

### label are 

### based upon responsible 

### experts' evaJualion of reasonable tesls ofeffectiveness, of loxlcJtyto laboralory animals andto **plants,** 

### and of residues on 1000 crops and upon reports of lield experience. Tests have not been made on all varielies or in all 

### state.orunderaU condlions. THE MANUFACTURER NEITHER MAKES NCR INTENDS, NOR DOES IT AUTHORIZE ANYAGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT EXPRESSLY EXCLUDESAND DISCLAIMS ALL IMPLIED WARRANTiES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNERWHICH IS INCONSISTENTWITH THE LABEL DIRECTIONS, WARNINGS OR CAUTIONS. BUYER'S EXCLUSIVE REMEDYAND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANYAND ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER OR NOT BASED IN CONTRACT, NEGLIGENCE. STRICT LIABILITY IN TORTOR OTHERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTiON, TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE PRICE FOR, THE QUANTITY OF PRODUCT WITH RESPECTTO WHICH DAMAGESARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECTOR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OFTHIS PRODUCT

.



### • 

### •••



## • ••••••

RhOno·Poulrmc AgCompany P.O. Box 12014, 2T.W. Alexandor Drive ResearchTriangle Park, North Carolina 27709 

### PREP is a trademark

### 01 RHONE·POULENC. PREpnI 4 Plant Rogulator for Colton (MASTER) Notification **619193.** 

### •••• 

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•• 

## • • • • •••••• 

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...**~** 

# ,

# ~ RHONE-POULENC



# •

• RH6NE-POULENC AG COMPANY 

## June8,1993 U. S. Environmental Protection Agency Office ofPesticideProgram DocumentProcessingDesk 

## Room 266 A, CrystalMall No.2 1921 Jefferson DavisHighway Arlington, Virginia22202 

### Attention: 

## Ms. Cynthia Giles-Parker ProductManager (22) FungicideHerbicide Branch 

## Registration Division (H7505C)

Dear Ms. 

### Parker:
RE: 

### Notification 93-3 

### Definition ofwetlands 

## Florel PlantRegulator EPARegNo264-263 Prep brand Ethephon for cotton and Tobacco 

## EPA RegNo264-418 Cerone2 Plant Regulator 

## EPA Reg No264- 376 Ethrel Ethephon Plant Regulator for Pineapples and Sugarcane 

## EPA RegNo264-257 Cerone4 Plant Regulatorfor Cotton 

## EPA Reg No264-380 Ethrel PlantRegulator 

## EPA Reg No264-267 Cerone Plant Regulator 

## EPA RegNo264-377 o 000

00 0 o 0 0 o 

# ... " 

# . o • 0 o


# ......

o 0

• 

### Appended are application forms and labels for the following ethephon containil.tg.p1:oducts:..
o • o o 00 

### Thestatement" For terrestrial use, do not apply directly to water, to areas wheresurface wale,,: is present or to intertidal areas below the meanhighwater mark" has been added to each labcl under the Environmental Precautions Section. : .' 8 • • 

### Sillcerely,

# .z:/~--**~ d~_A':'**  Warren A. Davis
PO BOX

## 1~pjR9**J\~!~tA"eMStn** Manager fi,,-SEARCH TR'ANGU:' r;CRr:: NC /leU) 1['f9) 5-18 2\J{)() :NTEHNMiONAL 7no. f<0V,SLR .1<)<YDf!J ,\1<.:,',',,< 

### ,,8!<><N'C HlP iNTf:l1tiATiQtML iJlSW'UUrlQNsrfl'.-,!";C; 1"1.f1Iil)'.lE[fl .:¥.f(:i;--<'.f,SWLR8N:K M-": iU:_, 000 • 0 o 0
00 0

Excelfence itl Performance P"Ue In AC/llevernelli 

# 120