EPA Reg. No. 264-380

Vol. 1

(this file does not include records prior to 1991)
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Unltod Statu Registration opp Identiflor Numb., 

&EPA Environmental Protection Agency 7.. Amendment 

W .. hington. OC 20460 Other 

for ,. II 

I. Compony/Product Number 2. EPA Product Manager 3. PlopO,ed CluJ/fieolion 

264·380 Giles-Parker o NOne o R •• lritted 

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Addrns of Applinnt (lncflJdll ZIP Cod.J 8. Expedited Roveiw. In accordance with F1FRA Section 3(c)[3) 

~~6~~~~PSclence [bUn, my product is similar or identical in composition and labeling 

. 12014,2 T.W. Alexander Drive to: 

Triangle Park, NC 27709 EPA Reo. No. 

0. ., "., ntw.ddross Name 

I , - II 

[2] Ame!ldment· Explain below. fine! printed rob.ls In repeonn r. 

Aglnoy Inll, delOIt 

R ... "lImiulon in rospon •• to AO.""y lotio' dotod -1.4 .. TooW APpn<lolion. rO Notilieolion - bplltin botew. Othe,· Exploin billow. 

Explanation: Use additional palla lsi it nlclSury. tFor sactlon t and Siciion 11.1 

REGFEE: Amendment to Roglitrntion - Regtstration of Alternate Confidon~1I1 Stalements 0/ Formula {CSFs), Fast track. FEE: Not Applicable. 

JUSTIFICATION: Tho proposed Altomale CSFs mnecl either emend,monts to the CSF for the MUP, Basa 250 {EPA Reg. No. 264-5(1), Of the use 01 new 

MUPS/Ofwh!ch Applications lor Rl.'{llstrotionJAmendmenls arc being submitted coneummUy with this submission. No new data roquired rorlhe proposed 

amendmenl to the subject end use producl· rely on existing data on Iile altho EPA No cha~e madllio lIle composition or the end usu product Detailed 

iust~'Jcations providad In tho attached letter. CONTACT; Danlelte A lllroclleHo, 9191549-27t8; IlM311: Oonlelto.larochetle@bayorCl'Opscleneo.ccm. 

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Packaging , I ,,' 

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No - No - N, r-- Plaatic 

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~MtilicatiOn mU3t ~~:.par ,..;~~: w~ ~!:rr 

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Pepar 

subm;tttHJ contotinar contoinar Oth.r , 

~ 0/ Not , 14. Slulsl AIIIIi ComDinor <CG. , 

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8. Mcnner in Which lab,t ia A,fthcad to Product t l~i:Zt,;~ o Other 

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, PolO! 

IN~' 1""' I T,lephora Ho. {lnctudo Aro. Codol 

Daniello A. Larochelle RegistraUon Manager, Insecticides (9(9) 549·27IB ; ••• :. 

Certification s, Oato 'ppliution 

Illonify that tho statlments I hllvo mlldo on thl$ rarm Ind ett attachmonts thoroto ara true. accurlto end , AoceilAt'· •• 

t ecknowledgt thot ony knowlinQlly lelu Ir mistu.dinQ statMllnt may bo p!.Inishabto by finl IrimpritoMlent Of! 

! : {Stampedl both 1111'1. • 

•. sr,,,,,,, (jJ{,tt( /t { (/1111 3. nt/a • • 

• • 

Registration Manager, Insecticides • •• 

•••• • • • " .. 14. TYJlod Nem. 5. Data .. :. . : • 

•••• 

Danielle A. Larochelle September 17. 2004 • • •••• 

fPA Form .. 70·' ,.". ,.94) ata ob,oIetd. Whit. - EPA Fa. Copy 

3 
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Bayer CropScience 

November 5, 2004 

Docunlcnt Proccssillg Desk (WD) 

Office of Pesticide Programs (7504C) 

U.S. Environmental Protection Agency 

1801 South Bell Street 

Arlington, Virginia 22202-4501 

AttentIon: Ms. Linda Arriuglon, RD 

Dear Ms. Aninglon, 

Rc: Withdrawal of Applications for Pesticide Amendment 

End Use Products Containing Ethephon 

On September ]7, 2004 Bayer CropScicncc submitted several applications 

for pesticide amendments for end IISC products containillg the active 

ingredient Elhcphon. The proposed amendments reflected 11) changes which 

are not yet approved forthe muuuf.1cturing usc product Base 250 

Confidential Statements of Formula (CSFs) and b) the usc of manufacturing 

use products which arc not yet registered. Base 211 Ethephon and Ethephon 

Manufacturing Concentrate (applications also submitted 9/17/2004). We arc 

therefore withdrawing the applications submitted for the following end usc 

products: 

ETHREL® brand Ethephon Plant Growth Regulator (For Pineapple and 

Sugarcane) - EPA Reg. No. 264-257 

FLOREL® bmnd Ethephon flam Growth Regulator - EPA Reg. No. 264~263 

ETHREL® brand Ethephon Plant Regulator - EPA Rcg. No. 264-267 

CERONE® brand Ethephon Plant Regulator ~ EPA Reg. No. 264-377 

PREpTM brand Elhephon Plam Regulator for COllon - EPA Reg. No. 264-380 

PREpnt brand Elhcphon for Cotton and Tobacco - EPA Reg. No. 264-4 If! 

FLOREL® brand G/R Plant Growth Regulator - EPA Reg. No. 264-543 

FINISHrID 6 PRO Harvest Aid for COItOIl - EPA Reg. No. 264-703 

For your convenience, copies oftlte Applications for Pcsticide Amendment 

(EPA Form 8570-1) submitted on September 17 ror these products are 

attached for reference. 

Please schedule the review of the Ap]llications submitted on September I til 

proposing CSr: umClldmellts for Base 250 and the registration of the new 

//2 

4 
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• 

November 5,2004 

Ms. Linda Arrington 

Pagc2of2 

Withdrawal of Applications for Pesticide Amendment (Cont'd) 

manufacturing use producls, Base 2J J Ethcpholl and Ethephon Mnnufacturing Conccmrate. Ollce 

these actions arc completed, the amendments for the producls listed nbovc will be rc~submittcd. 

Please Jet me know ifyollnced allY additiooal information. You can reach me at (9 J 9) 549-27 J 8 or by 

e-mail at n:lnieJ.!f~1mchcJk!l1 bavercrQ!1,l:jcncc.cmn. 

Sincerely, 

Danicllc A. Larochelle 

Registration Product Mallager 

cc: Ms. Cynthia Giles 'Parker. RD/PM22 

Attachments 

COrT. No. daL112·04 

5 
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Bayer Crop Science 

November 5, 2004 

Document Processing Desk (WD) 

Office of Pesticide Programs (7504C) 

U.S. Environmental Protection Agency 

180 I South BeU Street 

Arlington, Virginia 22202-45Oi 

Attention: Ms. Linda Arrington, RD 

Dear Ms. Arrington, 

Rc: Withdrawal of ApplIcations for Pesticide Amendment 

End Use Products Containing Ethcphon 8IJfi>' [:1 .. ",50"",* 

RTF 

;:- 0 lb.' 1"'.11.; 

PTF. t;C :;.,,08 

Td !i1&f4S":'Don 

A II ovr-e Cool e".( 

w;tt, A. c, 350, 

On September 17,2004 8aycrCropScicnce submitted several applications 

for pesticide amendments for end usc products cootaining the active 

ingredient Ethephon. The proposed amendments reflected a) changes which 

are not yet approved for the manufacturing usc product Base 250 

Confidential Statemeots ofFonnula (CSFs) and b) the usc of manufacturing 

use products which are not yet registered, Base 2 I I Etllcphon and Ethephon 

Manufacturing Concentrate (applications also submitted 9/i7J2004). We arc 

therefore withdrawing the applications submitted fOf the folJowing cnd use 

O'f' I',"'it ~ products: 

trc*'io V\ l.J ;:d.r-c.:.w~- /lJD3SI1l7?/S771'J 19 

FLOREL® brand Ethephon Plant Growth Regulator * EPA Reg. No. 264*263 'D3'SI "i!73fs771 Y 2..0 

ETHREL® brand Ethephon Plant Regulator * EPA Reg. No. 264·267 D .3 S I "'Z' 7 ~ / S 77 \ l{ 2. \ 

CERONE® brand Ethcpbon Plant Regulator * EPA Reg. No. 264·377 1).3 S'\ 'is 7 .s / 577 I Lf. ':2 2.. 

PREpTM brand Ethcphon Plant Regulator for eolian * EPA Reg. No. 264*380 i)3S' t 'g 7b/.:s 77 {Y 2. 3 

PREpThl brand Ethephon for Cotton and Tobacco * EPA Reg. No. 264-418 D3S t '8 7 7/ s 7 71 L.{ 2. L{ 

FLOREL® brand GIR Plant Growth Regulator- EPA Reg, No. 264*543 D3S1 '1S 7'ft/ S 77 / L/2 S 

FfNISH® 6 PRO Ilarvcsl Aid for Colton * EPA Reg. No. 264-703 D 35" / 157 '1/5:7 71 Lj 2. t;; 

S e"7 • ETHREL® brand Ethephon Plant Growth Regulator (For Pineapple and 

C0'V\ • Sugarcane) ** EPA Reg. No. 264·257 

For your convenience, copies of the Applicatioos for Pesticide Amendment 

(EPA Fonn 8570* I) submitted on September 17 for these products arc 

attached for reference. 

Please schedule the review oftbe Applications submitted on September 17!h 

proposing CSF amcndmcnts for Base 250 and ~le registration of the new 

li2 

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• 

November 5, 2004 

Ms. Linda Arrington 

Page 2 of2 

Withdrawal of Applications for Pesticide Amendment (Cont'd) 

manufacturing use products, Base 211 EthepllOn and Ethephon Manufacturing Concentrate. Once 

these actions are completed, the amendments fot the products listed above will be re-submitted. 

Please let me know if you need any additional infonnation. You call reach me at (919) 549-2718 or by 

c-mail at Danie!Jc.Laroclie!!c(whllvcrcropscic!!cc.com. 

Sincerely, 

DameIIe A. Larochelle 

Registration Product Manager 

cc: Ms. Cynthia Giles Parker, RDlPM22 

Attachments 

Corr. No. daLl 12-04 

, ,v< 

7 
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• 

l\(1VClllocr 5, ~004 

DO(.'Il!nl.'lli I'roC<.!SSI11¥ Do.:~k (WDj 

OllieI.' ofPe;;(icidc Prognl!lls (7504('] 

U.s. Elwironlllt:llt:lll'rolcclioll AgclH.:Y 

IIW I South B.::l1 Street 

Ari(l(ghHI. \,irgil!'111 n:::!(),2-4501 

Altcntiol1; Ms. Linda Alring-t((lI. RD 

Dear \{.;. Arrington. 

Re: Wilhdnlwal of AppJiClltilllls ((\t. Pesticide A1l1CJldI11l'Ut 

End Usc Prod11cts Containing EthcpllOll 

On Seplenlhcr Ii, 1004 B:I)w CropSt;icllce suhmiltcd sc\"cral III)piicati((lIs 

for pes1icidc amendments fiJr cl1d lise prOilliCb containing the active 

ingrediellt Ethcphon. Th~' proposed arlltlldlllcnts reflected a) c1wllgcs \l'IJich 

are not yel <lppron~d for 111(: (J111llufllcluring (lSI.' prodncl Base 250 

Confidential SialCI11Cl11 s or F orlllul:l (CSFs) alld b) 1111.' usc oflnalllliac(uri IIg 

((SC product.>: which :11"1.' nOl y<.!l rcgislcrcd. Base ~II Elhcrlmlllll(d Edlcrllnn 

\1,lIlUfllclUring COII~'entn!1C (lIppl ic.l1iolls Illso sllbmiued 91 I 7/2004). \\\' arc 

lhcrcforc withdnnrillg the IIpplitali((ns sllhmillcu lor lile foll,~wing cud lise 

proJlIcts: 

ETI-IREJ}).t: brand Elherl(((ll PI;!lll (jrowl h Regulator I For Pi lH:applc alld 

Sugarcalle) -- EPA Reg. No. 264-257 

FLORELR brllild ElhepllOll Plall1 Growth RegUlator - EPA Reg. 1\1). 264-263 

ETI-IREIA> hr<l(Iu Etl(Cpl(!(I( l'hlill Rcgllialor - EPA Reg. N(1. 264-267 

CERONbir hmnd 1:1hepl1((11 Plant Reguilitor- EPA Rl.'g. No. 264-377 

I'!tEp a1 hral(d Ethephon Pbn( R~'g(\lator fiJr ('011011- EPA Reg. No. 2M-3XO 

PREI'r.-., hrand EthqdlOli l'or CotWn ,md Tohacco - EPA Reg. 1'\0_ 264-41 S 

FLOIU~U\' br<IIIJ (ifR Plant Growth Rcgu];ltor - EPA Reg. No. 1M-54} 

FINISlld('6 PRO I-hlrvcst ,\id forCouml - EPA Reg. 1\0. 264-703 

For your eonvcnkncc, C\lpk's uJ" 11le APJ11k;(tioll;; for Pesticide :\l1lcndm~'1l1 

(EPA F((nll :-557((·1) S(lhlllillcd Oil SC]llcmber J7 n(r th~·"e pro(hl~'IS arc 

allachcd for rcf~'rcnCl·. 

Pkas~' SdlCUlik thc rCI iell' or the Appl iCfltiollS slIIJlllillCd ((11 Se)ltCIl1IICr I r:' 

pruposil(,!!. ('SF ,IIlIClhlll1cnlS fox Base 250 ;md lhl.! rcgislrali(]11 oftln: new 

8 
• 

., 

Nlwcnlher S, 1004 

~h. Linda Arl"ingh11l 

Page::! Dr~ 

WfthdntwaJ of ApplicaHulIS f(lr Pcstidd(> Amcndmcill (Cont'd) 

rnallur:I\"nlflllg us!: pro\l(l\'\S, Bas..: 211 l:thcphull <lIlU Etllcphnll \1f1lluliwlOring COIl(:CllIrUle. 011(.'\' 

these actiDns <1n: t::ompio.:!cd. tlte anu.:numcncs I'm tIlt jlf<.lUlICIS listed <lbvvc will be rc-suhlniucd. 

Plc<lSC kl me kuow IrYlllllli:~·d <I(l~ additional ilirmlll;ulmL '{ou C,lll n~adl Olea! i()lqj 5·l9-27IR or h} 

C -Ill;) i 1 a! Ui.!I]]yllL L,'.!!..~') J!dk ~!iJ;;!..; fl O'X'}l'.~,S I"')J~~ __ <;!2.~!i • 

Silll.:crcly. 

Danicllc A. Larochelle 

Rcgislr,J(ioll I'rO(hll.:l ;v1:lnagcr 

cc: /I.'Is.. Cynthi:! Giles Parker. RJ).'PM22 

AIWclUJICOIS 

COlT. No. JnL I )~+!l.j 

9 
OM", 

&EPA 

Unitod StOtO, ti: Registration I oPP Identifier Numbor 

Environmental Protection Agency Amendment 

Washington. DC 2046{) Other 

, for , , - , , I 

'.' 2. EPA Product Meneger Classificotion 

. Cynthia Giles-Parker 

DNone o Rastrictlld 

4. , " •• m.' PM' 

Colton Team 22 

5. Nom., ond Address 01 Applinn! (Ine/!Jdll ZlP Cod., 6. Expedited Reveiw. In accordance with AFRA Section 3(cJl3) 

~:6:;,ox-120'4.,2-T w NC 27709 

Ibllil. my product is similar or identical in composititln and labe~no 

to: 

EPA Reg. No. 

o Check if till$ is It MW IIddft/:S Product Name 

, - II 

Amondmont· ExplaIn b.tow. U Anal printed lebot. in rapun .. to 

o n .. "bml .. lon In , .. ,,,,,,sa 10 A.,.ncv lanar dated 

o Ageney louer datod 

-Me Too· Applicetio". I 0 NoliUcolien' Explain below. o Other· Explain bolow. 

Explanation: u"o odditional pogal.) tr noc"lIUry. IFor nction t ond Section tt.l 

REGFEE: Amendment 10 Registration - ReGistration 01 A1temate COfIfidantial Stalemenls 01 FOI'mufa (CSFs). Fasl track. FEE: Not Applicabl(l. 

JUSTIFICATION: The proposed A1temate CSFs reOeet ailhOf llmandmenls 10 tho CSF lor the MUP, Baso 250 (EPA Reg. No. 264.5(1). or the use of new 

MUPs (or which ApptlcaUOflS!of R09isITaiion/AImlndmeniS aro baing submitted concurrentlywilh this submission. No nowdala required for tho proposed 

Grnono'monl to the subJect end usa producl- rely on existing data on me altho EPA. No chango mado 10 tha composition 01 tha end usa product. Debiled 

iusti~C9tlonS plovtdad In Ihe attached !ottar. CONTACT: Danletlo A.larocl1eHe, 919/549-2118; eMait: DanleUe.larochetle@bayercropsc/onco.com. 

, - III 

""., " .. , "," ., Packaging I Uo;" --" i 2. Type ot Containor Et E y" Y .. Ef"· .0 No - .0 PI •• tic 

GlelS 

I :ltc::t~%:n mU!lt III -.y,,- No. por I!.:t~~: wot No. per Papor 

wgt. cont,inar containor Other 

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G. Monn.r in Whk:h Labat i, Afnxod to Product o Oll'lllr 

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.~. 11 •• T olophono No, ilneJl",,.w Codol 

Oanielle A, Larochelle Reglslralion insectlcldes {919}549-21t8 • 

Certffication ••• : 

I~ I conilv thll tho slltemonls I hln mlldo on this form and all,ttlchmlnts thorllo 01'11 true, occurale and compleQt. • t ocknowt&dgo that eny knowtingHy fain or mide&dinO $I0tlment mev be punishabto by fine or imprbonment or • (Stamped) bolh 

2. ,;,0''''' W{1t{ /l { (I/ill 3. Tiue . I' : • " • • • 

Registration Manager, Insecticides ": I' . • ••• 

• • 

.~. 5.0eta • ••• 

• • ., .. Danielle A. Larochelle September 17, 2004 •••• • 

EPA FMm 8510·' ,.". '·94) i , ... W1>It, -, ,,,,,,InO' 'Cooy 

10 
••••• • NOT REVIEWEIJ. :::: 

In Accordance with PR Nt>l\c~ B2{i: 

PRE pTM brand Ethephon 

PLANT REGULATOR FOR COTTON 

Based on Draft Labeling Dated • 

FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. 

NOT FOR RESIDENTIAL USE. 

ACTIVE INGREDIENT, 

!7 d7- ;? ""c".7.- • I. 

• • • • 

• 

• • • • • • • • 

• · . · • • 

- .. • • • 

Ethephon (2-chloroethyl) phosphonic acid" ........ , ............................................................................................ 39.9% 

INERT INGREDIENTS' •...................................•...•.•.•.•.•.•.•.•...•.........•....•......••..•..........•.•.......•...............................•.• 60.1 % 

-This product contains 4 pounds elhephon per galion. 

EPA Reg. No. 264-380 EPA Est. No. 264-PA-Ol 

• 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

Si usled no enliende la eliqueta, busque a alguien para que sa la explique a usled en detalle. 

(If you do not understand the Jabel, find someone to explain it to you in detaiL) 

For MEDICAL And TRANSPORTATION Emergencies 2N.LY Call 24 Hours A Day 1-800-334-7577 

For PRODUCT USE Information Call1-866-99BAYER (1-866-992-2937) 

• • • • • • • • • • 

The use of this product for a variety of plant growth regulaUon uses Is covered by United States and foreign patents Including 

U.S. Patent 4,240,819. No llcense is granted to use this product in countries other than the United States or for any use not 

contemplated by this label. Liability for patent infringement may result from use or sale of this product outside the United States. 

FIRST AID 

IFtN EYES: • Hold eye open and rinse slowly and gently with water for 15·20 minutes. 

• Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. 

Call a oo;,on control cenler or doclor' I ad,;ce. 

IFON SKIN OR • Take off contaminated clothhg. 

CLOTHING: • Rinse skin immediately with plenty of water for 15·20 minutes. 

,. Call a Do;,on conlro' , rdoclor' I ad';ce. 

SWALLOWED: • Immediately call a poison control center or doctor for treatment advice. 

• Do not induce vomiting unless told to do so by a polson control center or doctor. 

• Have person sip a glass of water if able to swallow. 

• Do not, I by mouth 10 an , Deo;on. 

For MEDICAL Emergencies Call 24 Hours A Day 1~800-334-7577. 

Have tho I w;!h YOU when II 

NOTE TO PHYSICIAN, Treat symptomatically. Consideration should be given to the possibility that overexposure to materials 

other than this may have occurred. No specific antidote Is available. Probable mucosal damage may contraindicate the 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

Corrosive. Causes Irreversible eye damage and skin irritation. Harmful if swallowed or absorbed through skin. Do not get in eyes, on 

skin, or on clothing, 

Harmful or fatal if swallowed. Avoid contamination of food. 

11 

• • • • ••• 

• • 
PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and other handlers must wear rong-sleeved shirt and rang pants, chemical resistant gloves mad~ of <!ny waterproof 

material (such as Nitrile, Butyl, Neoprene andlof Barrier Laminate), shoes plus socks and protective eyewear. • • 

When handlers use closed systems, enclosed cabs, or aircraft In a manner that meets the requirements listed in the Worker Protection 

Standard (WPS) for agricultural pesticides 140 CFR 170.240 (d) (4-6)], the handler PPE requirements may be reduced or modified as 

specified in the WPS. 

Discard clothing and other absorbent materials that have been drenched Of heavily contaminated with this product's concentrate. Do 

not reuse them. Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables, use detergent 

and hot water. Keep and wash PPE separately from other laundry. 

User Safety Recommendations 

Users should wash hands before eating, drinking, chewing gum, using tobacco or using the toilet 

Users should remove clothing Immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. 

Users should remove PPE immediately after handling this prOduct As soon as possible, wash thoroughly and change into clean 

clothing. Wash the outside of aloves before removing: 

ENVIRONMENTAL HAZARD 

•

VOld spray drift to nearby crops as this product may cause temporary modifications in plant growth. Do not contaminate water used 

r irrigation or domestic purposes. 

Do not apply dlrectry to water, or to areas where surface water is present or to intertidal areas below the mean high waler mark. Do not 

contaminate water when disposing of equipment washwaters. 

Do not exceed the rate of PREpThl brand EthephOn Plant Regulator for Cotton per acre per year recommended on this label. 

SPRAY DRIFT 

Avoid spray drift. Do not apply when weather conditions may cause drift. Do not allow this product to drift on to non-target areas. Drift 

may resurt in illegal residues or injury to adjacent crops and vegetation, in the form of teaf yellowing and defoliation. To avoid spray 

drift, DO NOT apply aerially when wind speed Is greater than 10 mph or during periods of temperature inversions. Use of larger 

droplet size will also reduce spray drift. 

AVOIDING SPRAY DRIFT AT THE APPLICATION SITE IS THE RESPONSIBILITY OF THE APPLICATOR. 

The interaction of many equipment-and-weather-related factors determIne the potential for spray drift. The applicator is responsible for 

considering all these factors when making decisions. 

The following drift management requirements must be followed to avoid off-target movement from aerial applications to agricultural 

field crops. These requirements do not apply to forestry applications, public health uses or to applications using dry formulations. 

1. The distance of the outer most nozzles on the boom must not exceed 3/4 the length of the wingspan or rotor. e Nozzles must always point backward parallel with the air stream and never be pointed downwards more than 45 degrees. 

Where states have more stringent regulations, they should be observed. 

The applicator should be familiar with and take into account the information covered in the Aerial Drift Reduction Advisory below: 

AERIAL DRIFT REDUCTION ADVISORY 

[This section is advisory in nature and does not supersede the mandatory label requirementsj. 

INFORMATION ON DROPLET StZE 

The most effective way to reduce drift potential is to apply large droplets. The best drift management strategy is to apply the largest 

droplets that provide sufftcient coverage and control. Applying larger droplets reduces drift potential, but will not prevent drift if 

applications are made improperly, or under unfavorable environmental conditions (See Wind, Temperature and Humidity, and 

Temperature Inversions). 

CONTROLLING DROPLET SIZE 

Volume - Use high flow rate nozzles to apply the highest practical spray volume. Nozzles with higher rated flOws produce larger 

droplets. 

Pressure - Do not exceed the nozzle manufacturer'S recommended pressures. For many nozzle types lower pressure produces larger 

droplets. When higher flow rates are needed, use higher flow rate nozzles instead of Increasing pressure. 

Number of nozzlas - Use the minimum number of nozzles that provide uniform coverage. 

Nozzle Orientation - Orienting nozzles so that the spray is released parallel to the airstream produces larger droplets than other 

orientations and is the recommended practice. Significant deflection from horizontal will reduce droplet size and increase drift 

potential. 

12 
Nozzle Type· Use a nozzle type that is designed for the Intended application. With most nozzle types, narrower spray angles produce 

larger droplets. Consider using low-drift nozzles. Solid stream nozzles oriented straIght back produce the largest droplets and the 

lowest drift. 

BOOM LENGTH 

For some use pattems, reducing the effective boom length to less than 3/4 of the wingspan or rotor length may further reduce drift 

without reducing swath width. 

APPLlCATtON HEtGHT 

Applications should not be made at a height greater than 10 feet above the top of the target plants unless a greater height is requIred 

for aIrcraft safety. Making applications at the lowest height that is safe reduces exposure of droplets to evaporation and wind. 

SWATH AOJUSTMENT 

When applications are made with a crosswind, the swath will be displaced downwind. Therefore, on the up and downwInd edges of 

the field, the applicator should compensate for this dIsplacement by adjusting the path of the aircraft upwInd. Swath adjustment 

distance should Increase, with Increasing drift potential (higher wind, smaller drops. etc.). 

WIND 

Drift potential Is lowest between wind speeds of 2 • 10 mph. However, many factors, Including droplet size and equipment type 

determine drift potential at any given speed. Application should be avoided below 2 mph due to variable wind direction and high 

inversIon potential. NOTE: Local terrain can influence wind pattems. Every applicator should be familiar with local wind pattems and 

how they affect spray drift. 

eEMPERATURE AND HUMIDtTY 

When making applications in low relative humidity, set up equipment to produce larger droplets to compensate for evaporation. 

Droplet evaporation is most severe when conditions are both hot and dry. 

TEMPERATURE INVERSIONS 

Applications should not occur during a temperature inversion because drift potential Is high. Temperature inversions restrict vertical air 

mixing, which causes small suspended droplets to remaIn in a concentrated cloud. This cloud can move in unpredictable directions 

due to the light variable winds common during inversions. Temperature inversions are characterized by increasing temperatures wIth 

altitude and are common on nights with limited cloud cover and light to no wind. They begin to form as the sun sets and often continue 

Into the morning. TheIr presence can be indicated by ground fog; however, if fog is not present, inversions can also be Identified by 

the movement of smoke from a ground source or an aircraft smoke generator. Smoke that layers and moves laterally In a 

concentrated cloud (under low wind conditions) Indicates an inversion, while smoke that moves upward and rapidly diSSipates 

indicates good vertical air mixing. 

SENSITIVE AREAS 

The pesticIde should only be applied when the potential for drift to adjacent sensitive areas (e.g. residential areas, bodies of water, 

known habitat for threatened or endangered specIes, non-target crops) is minimal (e.g. when wind Is blowIng away from the sensitive 

areas). 

DIRECTIONS FOR USE e It Is a vIolatIon of Federat taw to use thIs product In a manner InconsIstent with Its labeling. 

Do not applythts product In a way that will contact workers or other persons, eIther directly or through drift. Only protected 

handlers may be In the area durIng applicatIon. For any requIrements specific to your State or Trlbe, consult the agency 

responsIble for pesticIde regulatIons. 

Road enUre label before using thIs product. 

AGRICULTURAL USE REQUIREMENTS 

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR part t70. This standard 

contains requIrements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of 

agricultural pesUcides, It contains requirements for training, decontamination, notification, and emergency assIstance. It also contains 

specific Instructions and exceptions pertaining to the statements on this label about personal protective equipment (PPE), notification 

to workers and restricted-entry interval. The requirements in this box only apply to uses of thIs product that are covered by the Worker 

Protection Standard. 

Do not enter or allow worker entry into treated areas during the restricted-entry interval (REI) of 48 hours. The REI is 72 hours in areas 

where average rainfall is less than 25 Inches per year. 

PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with 

anything that has been treated such as plants, soli or water Is coveralls over long-sleeved shIrt and long pants, chemical resIstant 

gloves made of any waterproof material, such as nitrile, butyl. neoprene, or barrier laminate, chemical resistant footwear plus socks, 

and protective eyewear, For overhead exposure, chemical-resistant headgear is also required. 

Notify workers of the application by warning them orally and posting waming signs at entrances to treated areas. 

13 
STORAGE AND DISPOSAL 

Do not contaminate water, food, or feed by storage or disposal. 

PESTICIDE STORAGE 

Store in a cool, dry place and away from food, feed and other pesticides. IF SPILLED: If container is broken or contents have spilled, 

follow all precautions indicated above and dean up immedIately. Before cleaning up, pul on full length trousers, long sleeved shirt, 

protective gloves, and goggles or face shield. Soak up spill with absorbent media such as sand, earth or other suitable material and 

dispose of waste at an approved waste disposal facility. 

PESTICIDE DISPOSAL 

Pesticide wastes are acutely hazardous. Improper disposal of excess pesUcide, spray mixture, or rinsate Is a violation of Federal law. 

If Ihese wastes cannot be disposed of by use according to Jabel instructions, contact your State Pestlcide or Environmenta[ Control 

I Ac,en,,, or the Hazardous Waste representative at the nearest EPA Regional Office for guidance. 

t CC'NTJ'III 'ERDISPOSAL 

rinse (or equivalent) the empty conta·lners. Then offer for recycling or reconcfltioning, or puncture and dispose of'ln a ""iI',,,,\ 

[ II or by incineration or if allowed by state and local authorities, by bumlng. [f container is bumed. stay out of smoke. 

RETURNABLE -- REFILLABLE CONTAINERS 

use, return the container to the point of purchase or designated locations. This container must only be refil[ed with PREplM 

Ethephon for Cotton and Tobacco. DO NOT REUSE THE CONTA[NER FOR ANY OTHER PURPOSE. Prior to remling, inspect 

I for as cracks, punctures, abrasions and damaged or worn out threads on closure devIces. Do not refill 

contaIners. Check for leaks after refilling and before transportation. If the container is not being refilled, 

GENERAL INFORMATION 

A foliar spray of PREpm brand Ethephon Plant Regulator for Cotton will accelerate opening of mature unopened cotton bolls and 

enhance defoliation which can result in earlier harvest with an increased recoverable yield. PREP"" brand Ethephon Plant Regulator 

for Cotton treatment allows Increased efficiency from a once-over harvest. 

Some premature drop of small. immature bolls may be associated with treatment. 00 not apply before suffICient, mature. unopened 

bolls have developed to produce the desired yield of cotton. 

A boll is mature when it is too hard to be dented when squeezed between thumb and fingers. too hard to be sliced with a sharp knife, 

and when the seed coat becomes light brown in color. 

For best results, thorough and uniform spray coverage Is requIred. It is essenlialthat the bolls are contacted by the spray to obtain 

optimum boll opening. Observe treated fields closely. Harvest at optimum boll opening and defoliation. generally 14 to 2 t days after 

treatment. Sustained cold weather with average day and night temperatures of 65~F or lower after treatment with PREP"" brand 

Ethephon Plant Regulator for Cotton will delay the boll opening response. 

DO NOT APPlY PREpm BRAND ETHEPHON PLANT REGULATOR FOR COnON IF RAIN [S EXPECTED WITHIN 6 HOURS. 

aainfall within 6 hours of application may reduce product performance. 

~ertifled cotton seed growers should observe boll and seed maturity before treatment with PREP"" brand Ethephon Plant Regulator 

for Colton. Bolls not completely mature might open with treatment of PREP"" brand Ethephon Plant Regulator for Cotton giving lower 

quality seed. 

IMPORTANT: Do not apply PREpm brand Ethephon Plant Regulator for Cotton through any type of Irrigation system. 

SPRAY PREPARATION 

Add 112 to 3/4 of the reqUired amount of water to the spray tank. Start agitation. Add the required amount of PREplJ.I brand Ethephon 

Plant Regu[ator for Cotton, and the remaining amount of water. Prepare only as much spray solution as can be used on the day of 

mixing. 00 not allow spray solution to stand overnight. 

Do not spill the concentrated product on spray equipment, or any airplane parts. ANY SPILLS SHOULD BE RINSED IMMEDIATELY 

WITH PLENTY OF WATER. 

Use of a nurse tank is hIghly recommended for avoiding possible spillS of concentrated formulation on spray equipment or any airplane 

parts. 

EQUIPMENT CLEANING 

Spray deposits of PREpm brand Ethephon Plant Regu[ator for Cotton, when left on aircraft acrylic plastic type windshields for longer 

than t hour, may react with this material, forming an opaque film or spots on the surface which cannot be removed by washing with 

water or any other cleaner. Rinse windshields with water Immediately after each tankload of PREplM brand Ethephon Plant Regulator 

for Cotton has been applied. Thoroughly rinse the aircraft with clean water after each day PREp1lI brand Ethephon Plant Regulator for 

Cotton Is applied. 

PREP'''' brand Ethephon Plant Regulator for Cotton may also affect certain paints. and if accidental deposits on painted objects such 

as cars, trucks, agricultural eqUipment. etc. occurs, these obrects should be rinsed with water as soon as possIble (within 1 hour) to 

prevent permanent staining of the painted surface. 

14 
Because of the acidic nature of this product, prolonged exposure to spray deposit will damage acrylic plastics, certain paints, and 

metals. 

Rinse thoroughly with a detergent and water all exposed acrylic plastic-type materials (e.g., aircraft windshields), and painted surfaces 

within an hour after exposure to spray deposits. Attha end of e@ch day, rinse thoroughly with a detergent and water all the metal parts 

of the aircraft and the associated spray equipment exposed to the spray deposits. 

BOLL OPENING 

CONDITIONS EXPECTED 

5·7 DAYS AFTER 

TREATMENT 

Hot and dry 80'F or higher 

Dry with temperature 

75"F to 80'F 

Cool but higher than 6S"F 

Rates For Boll Oeenlng 

PREpm brand EtMPhon ONE GALLON OF 

Plant Regulator for Cotton PREpm brand Ethephon 

Plant RegUlator for Cotion 

QUARTS/ACRE TREATS 

1.0{1.0Iba.l.) 

1.S (1.Slb a.i.) 

2.0 (2.0 Ib aJ.) 

4 Acres 

2.S Acres 

2 Acres 

SPRAY VOLUME 

GAL./ACRE 

GROUND AIR 

1S to SO 

1Sto SO 

1Sto SO 

2to S2to S· 

.-ank cotlon 2.0 (2.0 Ib a.L) 2 Acres 25 to SO 

2to 5' 

5 

WNOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications 

Time of Application (Boll Opening) 

Apply when there are sufficient mature unopened bolls to produce the desired yield, but no later than when 60% of the bolls are 

opened (see General Information section on how to test for boll maturity). Do not tank mix PREP"" brand Elhephon Plant Regulator 

for Cotton with a desiccant If the cotton Is to be spindle harvested. 

15 
PRECONDITIONING FOR DEFOLIATION 

Rates For Preconditioning For Dofollatlon 

CONDITIONS EXPECTED 

5·7 DAYS AFTER 

TREATMENT 

Hot and dry 80'F or higher 

Cool but higher than 65'and 

also for rank cotlon 

PREP'"" brand Elhephon 

Plant Regulator for Colton 

QUARTS/ACRE 

0.5 (O.Slb a.l.) 

1.0 (1.0 Ib a.L) 

ONE GALLON OF 

PREpTM brand Ethephon 

Plant Regulator for Cotton 

TREATS 

8 Acres 

4 Acres 

SPRAY VOLUME 

GAL/ACRE 

GROUND AIR 

151050 

151050 

2 to S· 

2 to 5~ 

·NOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications. 

Tlmo of Application (Preconditioning) 

Apply PREpn> brand Ethephon Plant Regulator for Cotlon 410 7 days prior to application of deroliant or tank mixed with the defoliant 

(see section on Compalibmty). Do not lank mix PREPn.< brand Elhephon Plant Regulator for Cotton with desiccants unless plant 

fteSiccation is required. 

Pre-treatment With Defoliants Prior to PREpm brand Ethophon Plant Regulator for Cotton Troatmont 

If the cotton is overly rank or laying down in Ihe middles and good spray coverage of the bolls with PREpTh! brand Ethephon Planl 

Regulator for Cotton Is difficult, a pretreatment with defoliants will be useful to improve boll coverage with PREp1M brand Ethephon 

Plant Regulator for Cotton. Use dosage rates of PREpTM brand Ethephon Plant Regulalor for Cotton recommended for boll opening. 

Read and observe all appropriate label use directions and precautions for the defoliant used. 

Do not use a defoliant before there are sufficient mature unopened bolls to produce the desired yield (see General Information section 

on how to test for Boll Maturity). 

COMPATIBILITY 

PREpTM brand Ethephon Plant Regulator for Colton is compatible with DEF, FOLEX, DROPP, HARVADE, METHYL PARATHION, 

GUTHION AND MALATHION, and may be applied in sequence or as a tank mixture (DO NOT TANK MIX WITH DEFOLIANTS OR 

DESICCANTS IN CALIFORNIA AND ARIZONA). In some cases slight reduction in boll opening response has been observed when 

tank mixes with defoliants were used. 

Good agitation in the spray tank is essential and a tank mixture should not be allowed to stand without agitation for more Ihan 5 to 10 

minutes. Read and observe all appropriate label use directions and precautions for the defoliants and insecticides used. 

aRECAUTION, 

t.lOTE: UNDER CERTAIN CONDITIONS, TANK MIXTURES OF PREpTh! BRANO ETHEPHON PLANT REGULATOR FOR COTTON 

~WITH DESICCANTS CONTAINING SODIUM CHLORATE COULD RESULT IN THE FORMATION OF HYPOCHLOROUS ACIDS 

WHICH ON HEATING WILL EMIT TOXIC CHLORIDE FUMES. 

DO NOT MIX PREpTh! BRAND ETHEPHON PLANT REGULATOR FOR COTTON WITH AMMONIUM THIOSULFATE. SUCH TANK 

MIXTURES MAY RESULT IN FORMATION OF TOXIC FUMES. 

WHEN TO HARVEST: 

Do not harvest cotton sooner than 7 days after a treatment with PREpm brand Ethephon Plant Regulator for Colton. Observe the 

treated crop and harvest when optimum boll opening has been reached. Too early harvest might reduce the fun advantage of the 

treatment and too late a harvest may result in reduced quality and loss of lint which will drop from the plant. 

USE LIMITATIONS 

Do not exceed a maximum of 2.0 lb. ethephon active ingredient per acre per year through combined or repeated uses of any 

ethephon products. 

Boll Opening: Do not tank mix PREpTM brand Ethephon Plant Regulator for Colton with a desiccant if the cotton is to be spindle 

harvested. 

Pre-Condition for Defoliation: Do not tank mix PREpTM brand Elhephon Plant Regulator for Cotton with desiccants unless plant 

desiccation is required. Do not use a defoliant before there is sufficient mature unopened bolls to produce the desired yield {see 

General Information section on how to test for boll maturity. 

Do not plant another crop within 30 days after treatment. 

USE PRECAUTIONS 

16 
Avoid spray drift to nearby crops as Ihis producl will cause modifications in plant growth. Plant injury or reduced yields will result. 

Mix only the amount of spray you expect to use each day, Do not allow mixed solution to stand overnight 

IMPORTANT: READ BEFORE USE 

Read the entire Directions for Use, Conditions, Disclaimer of Warranties and Limitations of Liability before using this product. If terms 

are not acceptable, return the unopened product container at once. 

By using this product, user or buyer accepts the following Conditions, Disclaimer of Warranties and Limitations of Liability. 

CONOITIONS: The directions for use of this prodUct are believed to be adequate and should be followed carefully. However, it is 

impossible to eliminate all risks associated with the use of this product. Crop injury, ineffectiveness or other unintended consequences 

may result because of such factors as weather conditions, presence of other materials, or the manner of use or application, aU of 

which are beyond the control 01 Bayer CropScience. All such risks shall be assumed by the user or buyer. 

DISCLAIMER OF WARRANTIES: BAYER CROPSCIENCE MAKES NO OTHER WARRANTIES, EXPRESS OR IMPUED, OF 

MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE OR OTHERWISE, THAT EXTEND BEYOND THE 

STATEMENTS MADE ON THIS LABEL. No agent of Bayer CropScience is authorized to make any warranties beyond those contained 

herein or to modify the warranties contained herein. BAYER CROPSCIENCE DISCLAIMS ANY LIABILITY WHATSOEVER FOR 

SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. 

LIMITATIONS OF LIABILITY: THE EXCLUSIVE REMEDY OF THE USER OR BUYER FOR ANY AND ALL LOSSES, INJURlES OR 

DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER IN CONTRACT, WARRANTY, TORT, 

NEGLIGENCE, STRICT LIABILITY OR OTHERWISE, SHALL NOT EXCEED THE PURCHASE PRICE PAlO, OR AT BAYER 

_ROPSCIENCE'S ELECTION, THE REPLACEMENT OF PRODUCT. 

4 Bayer CropScicnce 

Bayer CropSclence LP 

P,O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, North Carolina 27709 

1-866-99BAYER (1-866-992-2937) 

PREpm brand Ethephon Plant Regulator for Cotton (MASTER) Approved 11/27102. 

17 
• 

• 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

NOV :' 7 

Prasad Raa 

Avcntis CropScience 

2 T.W. Alexander Drive 

Research Triangle Park. North Carolina 27709 

Subject: 

Dear Mr. Raa, 

Prep brand Ethephon Plant Regulator for Cotton 

EPA Registration No. 264~380 

Your label amendment application dated August 12,2002 

OFFICE OF 

PREVENTION, PESTICIDES 

AND TOXIC SUBSTANCES 

The amended labeling referred to above, submitted in connection with registration under 

the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), as amended is acceptable, 

provided that you comply with the following conditions. 

I. You must make the following changes to the label: 

a. At ever), place in the label where it occurs, "PREP" (withollt any additional product 

name) or "PREP brand Ethephon" must either be changed to a nonspecific tcrm such as "this 

product" or else changed to "PREP brand Ethephon Plant Regulator for Cotton", the complete 

name of the subjcct product. "PREP" and "PREP brand Ethcphon" are also part of the name of 

EPA Reg. No. 264-418. 

b. In the "IF TN EYES:" subsection of the "FIRST AID" section, in the second statement 

add "eye" after "then continuc rinsing". 

c. In the first sentence in the "PERSONAL PROTECTIVE EQUIPMENT (PPE)" section, 

add "made of any waterproof material" after "chcmical resistant gloves". 

d. In the first sentence in the second-to-Iast paragraph in the "AGRICULTURAL USE 

REQUIREMENTS" section, change "chemical resistant gloves such as any waterproof gloves" to 

"chemical resistant gloves made of any waterproof material, such as nitrile, butyl, neoprene, or 

barrier laminate". 

18 

.. 
• 

• 

• 

C. Move the sentence "Do not contaminate water, food. or feed by storage Or disposal." in 

the "STORAGE" subsection of the "STORAGE AND DISPOSAL" section to just after the 

"STORAGE AND DISPOSAL" heading, change the name of the "STORAGE" subsection to 

"PESTICIDE STORAGE", and provide appropriate statements for spills specifically (not solely 

spills), in this subsection. 

f. In the fourth scntencc of tile fourth paragraph in the "GENERAL INFORMATION" 

section, change "Harvest at optimun boll opening ... " to "Harvest at optimum boll opening ... ". 

g. In the second paragraph oflhe "Pre· treatment With Defoliants Prior to PREP 

Treatment" subsection of the "PRECONDITIONING FOR DEFOLIATION" section, change 

", .. section on how th test for BoU Maturity ... tt to " ... section on flOW to test for Boll Maturity ... ". 

2. Submit one copy of your final printed labeling before you release tIle product for shipment. 

If these conditions are not complied with, the registration may be subject to c::mcellation in 

accordance with FIFRA section 6(e). Your release for shipment of the product bearing the 

amended labeling constitutes acceptance of these conditions. 

If you have any questions about this letter, please contact 10hn Bazuin at (703)305·7381. 

Sincerely yours, 

Cynthia L. GlIes-Parker 

Product Manager (22) 

Fungicide Branch 

Registration Division (7505C) 

AttacIunent: Label stamped "ACCEPTED with COMMENTS" 

19 
r PREpTM brand Ethephon 

PLANT REGULATOR FOR COTTON 

FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. 

NOT FOR RESIDENTIAL USE. 

ACTIVE INGREDIENT: 

Ethephon (2-chtoroethyl) phosphonic acid'" ........................................................... ' ..... n,. ......................................... ., •••••••••••••••••••• 39.9% 

INERT INGREDIENTS: .......................................................................................................................................................................... 60.1% 

*This product contains 4 pounds ethephon per gallon. 

EPA Reg. No. 264·380 EPA Est. No. 264·PA'()1 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

Si usted no entiende la etiqueta, busque a alguien para que se Ja explique a usted en delalle. 

(If you do not understand the label, lind someone to explain it to you in detail.) 

• 

.-----------IF~o'rMM~'RDllICA~lAAnnddIT&RA~N~S~P~O~R[TAAT~I~O~N"'~m"e~rgg.e"n~'r.;e"s~O~N~lYfC(.~ITI2Z.4IHHo~u"r'sAA1D".~y"~.8~O~O~.3~344"~7~5777,-----------­

For PRODUCT.ug Information (alf 1-88fJ-.AVENTIS (1-888-283-6847) 

The use of this product for a variety of plant growth regulation uses is covered by United States and loreign patents including 

u.s. Patent 4,240,8t9. No license is granted to use this product in countries other than the United States or for any use not contemplated by this label. 

liability for patent infringement may result from use O! sale of this product outside the United States. 

IF IN EYES: 

IFONSKIN OR 

CLOTHING: 

IF SWALLOWED: 

N~,~ TO PHYSICIAN: 

DANGER 

FIRST AID 

• Hold eye open and rinse slowly and gently with water for15-20 minutes. 

• Remove contact lenses, if present, after the first 5 minutes, then continue rinsing. 

• "'I tady;". 

• Take off contaminated clothing. 

• Rinse skin immediately with plenty of water for t5·20 minutes. 

• call , tadYke. 

• Immediately call a poison control center or ~octor for treatment advice. 

• Do not induce vomiting unless told to do so by a pOison control center or doctor. 

• Have person sip a glass of water if able to swallow. 

• 00 n" .;"" , to 'n 

For MEDICAL Emergencies call 24 HoursA Day 1-800-334-7Sn. 

ror I,youwhen,; 1 rdoctor, 

· No i II 

II . Consideration should be given than this 

PRECAUTIONARY STATEMENTS 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS •••••• 

. " 

... 

• ... •• 

• •• • COHosive. causes irreversible eye damage and skin irrilalion. Harmlul if swallowed or absorbed through skin. Do·not gerin eye~ on sjgn, or on 

clolhing. ACCEPTED •• : •• : : ••••• 

Harmful or fatal if swallowed. Avoid contamination 01 food. with COiUi\IEN'fS • •• • • ••• E • •• dl EPA Letter Dated:.... ••• 

• • ':; T •• : ••• 

lj,HI~ .. !111' F~d<,raI InQectiei1Ie, 

FUl!l;ic;,ll', "1111 Bwl!'lllk!de Aet, 

"H ~m,.!dt'<:, for 110" I"'~!idde 

'''gid'',;,,! l"";"r EPA 1!Pg. No, 

• 

•••• • • •••• 

... 

•• • · .. 
PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and other handlers must wear loug-sleeved shift and long pants, chemical resistant gloves (Slldl as Nitrile. Butyl, Neoprene and/or Barrier 

larninate). shoes plus S{)(ks and protective eyewear, 

When handlers use closed systems, enclosed cabs, or aircralt in a manner that meets the requirements fisted in the Worker Protection Standard (WPS) 

for agricultural pesticides 140 CFR 170.240 (d) {4-6)]. the handler prE requirements may be reduced or modified as spedfied in tile WPS. 

Discard <lothing and other absorbent materials that have been drenched or heavily contaminated with Ihis product's concentrate. Do not reuse them, 

Follow manufacturer's instructions for cfeaning/maintaining PPE. II no such instructions for washables, nse detergent and hot water. Keep arK! wash 

PPE separately Irom other laundry. 

User Safety Recommendations 

Users should wash hands belore eating, drinking, chewing gnm, using tobacco or using the toilet. 

Users should remove clothing immediately il pesticide gets inside. Then wash thoroughly and put on clean clothing. 

Users should remove PPE immediately after handlinllthis product As soon as possible, wash thoroughly and change into clean clothing. Wash the 

outside of gloves before removing. 

ENVIRONMENTAL HAZARD 

Avoid spray drift to nearby crops as this product may cause temporary nrodifications in plant growth. 00 nol contaminate water used for irrigation or 

domestic purposes. 

00 not apply diredly to water, or to areas where surface water is present or to intertidal areas helow the mean high water mark. 00 not contaminate 

_ater when disposing of equipment washwaters. 

'IBflo not exceed the rilte of PR[I>'~ brand fthephon t1ant Regulator for Collon per acre per year recommended on this label. 

SPRAY DRIFT 

Avoid spray drift. Do not apply when weather conditions nraycause drift. 00 not allow this product to drift on to non· target areas. Drift may resull in 

illegal residues or injnry to adjacent crops and vegetation, in the form of leaf yellowing and defoliation. To avoid spray drift, DO NOT apply aerially 

when w'uld speed is greater than 10 mph or during periods of temperature inversions. Use of larger droplet size will also reduce spray drift. 

AVOtDING SPRAY ORtFT AT THE APPLICATION SITE IS THE RESPONSIBILITY OFTHEAPPUCATOR. 

The interaction of many equipment~and·weatheHelated factors determine the potential lor spray drift. The applicator is responsible for considering 

all these factors when making decisions. 

The following drift management requirem(>nts must be followed to avoid off·target movement from aerial applications to agricuftural field crops. 

These requirements do not apply to forestry applications, public health uses or to applications using dry formulations. 

t. The distance 01 the ollter most nOllles on the boom must not exceetl3/4the length of the wingspan or rotor. 

2, Noules mHst always point backward tlarallel with the air stream and never be pointed dnwnwards more than 45 degrees. 

Where states have more stringent regulations, they shonld he observed. 

The applicator should be familiar with anrltake into account the information covered in the Aerial Drift Reduction Advisory below: 

.ERIAL DRIFT REDUCTION ADVISORY 

[This section is advisory in natme and does not super5ede tire nrandatory label requirements]. 

tNFORMA TlON ON DROPLET SIZE 

The most ellective way to reduce drift potential is to apply large droplets. lhe best drih management strategy is to apply the largest droplets that 

provide sufficient coverage and control. Applying larger droplets reduces drift potential, but will not prevent drift if applications are made improperly. 

or under unlavorable environmental conditions (See wind, Temperature and Hurni1tity, and Temperature Inversions). 

CONTROLLING DROPLET SfZE 

volume· Use Irish lIow rate nOl.zles to apply tire highest practical spray V{llume. Noules with higher rated lIows produce larger droplets. 

Presstlre· 00 not exceed the nozzle manulacturer's recommended pressures. For many nozzle types lower pres.sure produces larger droplets. 

higher lIow rates are needed, use higher flow rate noules instead of increasing pressure. •• • 

Number of nozzles· Use the minimum lrUlnber 01 n07.1les that provide uniform coverage. • ••••• 

• •• 

• .. •• . When 

NOllie Orientation· Orienting nozztes so that the spray is released parallel 10 the airstream produces larger dropl"s Uran!other orienTations and is the 

recommended practice. Signilicilut ddlectron Irom Irorilontal will reduce droplet size and increase drift potentiaL...... : ••• :. •• • NOllie Type - Use a noule type that is designed lor the intenderl application. With most noule types, narrower spr3"irfgles proQuc&J"rger droplets. 

Consider using low·drill uOllles. Solid stream noules oriented straight back produce the largest droplets and the h~~~l grift. • ••• : 

800M lENGTH :: • ••••• 

For some use patterns, redUCIng the eflective boom leugth to less thau 3/4 ot the wingspan or rotor length may further reduce 4rT'ff Mtllout reducing 

swath width. • ••• 

.. . •• ... • 

21 
APPlICAnON HEIGHT 

Applications shollld not be made at a height greater than 10 feet above the top of the target plants unless a greater height is required for aircraft safely. 

Making applications at the lowest height Ihat is safe reduces exposure of droplets to evaporation and wind. 

SWATH ADJUSTMENT 

When applications are made with a crosswind, tile swath will be displaced downwind. Therefore, on the up and downwind edges of tile field, the 

applicator should compensate for this displacemenl by adjusting the path of the aircraft upwind. Swath adjustment distance should increase. with 

increasing rfrift potential (higher wim!. smaller drops, dC.). 

WIND 

Drift potential is lowest between wind speeds of 2 . 10 mph. However, many factors, including droplet size and equipment type determine drift 

potential al any given speed. Application should be avoided below 2 mph due to variable wind dirC{tion and high inversion polentiaL NOTE: local 

terrain can influence wind patterns. Every applicator should be lamiliar with local wind patterns and how they affcrt spray drilt. 

TEMPERATURE AND HUMIDITY 

When making ,1pplications in low relative humidity, set ull equipment to produce I,lrger droplets 10 compensate lor evaporation. Droplet evaporation 

is most severe when conditions are both hot anrl rlry. 

TEMPERATURE INVERSIONS 

Applications shOUld not occur during a temperature inversion becanse drilt potential is high. Temperature inversions reslrict verlical air mixing, which 

causes small suspended droplets to remain in a concenlrated doud. TIlis cloud can move in unpredictable directions due to Ihe light variable winds 

common during inversions. Telnperature inversions are characterized by increasing temperatures with allitnde and are common on nights with limited 

cloud cover and light to no wind. They begin to lorm as the sun sets and olten continue into the morning. Their presence can be indicated by ground 

log; however, il log is not present, inversions can also be identilied by Ihe movement 01 smoke frorn a ground source or an aircraft smoke generator. 

Anoke thai layers and moves laterally in a concentrated cloud (under low wiud conditions) indicates an inversion, while smoke that moves upward and 

"IIIIIIlSpidly dissipates indicales good vertical air mixing. 

SENSITIVE AREAS 

The pesticide should only be af1plied when the potential lor rlrift to adjacent sellsitive areas (e.g. residential areas, hodies 01 water, known hahitat lor 

threatened or endangered species, non-target crops) is rninirnal (e.g. when wind is hlowing away from the sensitive areas). 

DIREUIONS FOR USE 

It is a violation of Federal law to use this product in a manner Inconsistent with its labelin&. 

Do not apply this product rn a way that wiff contact workers or other persons, either directly or through drift. Only protected handlers may 

be In the area during application, For any requirements specific to your State or Tribe, consult Ute agency responsible for pesticide 

regula\ions, 

Read entire label before using this product. 

USE REQUIREMENTS 

Use this product only in accordance with its Llbeling and with the Worker Protection Standard. <10 CfR p..lrt t70, This standard contains requirements 

lor the protection 01 agricultural workers on larms, lorests, nurseries, and greenhouses, anrl handlers 01 agricultural pesticides. It contains 

'~l";'''";,"ld01 training, decontamination, notilication, and emergency .1ssistance. It also contains spC(ilic instructions and exceptions pertaining to 

statements on this label abollt personal protective equi pluent (PPE), notification to workers and restricted-entry interval. The requiremellts in this 

only at1ply to uses 01 this prodllct that are covered by the Worker Protection Standard. 

not enter or alfow worker entry into treated areas during the restricted-entry interval (REI) 01 <18 hours. The REt is 72 hours in areas where average 

rainlall is less than 25 inches per year. 

PPE required lor early entry to treated areas titat is permitted under the Wnrker Proleclion Standard and that involves contact wilh anything that has 

been treated such as pia lie;, wi! or water is (overalls over 10llg-sfeeved shirt and long Ilants, chenlical resistant gloves such as any waterprool gloves, 

chemical r{'5istant lootwear plus socks. and protective eyewear. For overhead expoSllfe, dremical·resistant headgear is also reqllired. 

1 workers 01 them II entrances to treated areas. 

STORAGE AND DISPOSAL 

STORAGE 

Do not contaminate water, lood. or leerl by storage or disposal 

PESTICIDE DISPOSAL 

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• •• • •• • • 

••• • • • •• • 

• 

Pesticide wastes are acutely hazardous, Improper disposal 01 excl'S~ pesticide, spray lnixtllre, or rimate is a violatioij pLf&1I1V31 law: JI.t1.l~ wastes 

cannot be disposed 01 by use according to label instructions, contact your State Pesticide or Environmental Control A~lCY Or the ff.!lardous Waste 

representative at the nearest EPA Regional Oflice for guidance. •• •• :.: 

CONTAINER DISPOSAL •• :.. • ••• 

•• • 

Triple rinse (or equivalent) the empty containers. Then olfer lor recycling or reconditioning. or puncture and dispos~to'M a sanital}'"llMfiff. or by 

incineration or il allowed by state and local allthoritie$. by burning. II (01\tainer is bllrned, stay out 01 smoke_ •••••• 

•• • •• • 

• •• 

22 
GENERAL INFORMATION 

A loliar spray 01 PREP'~ brilnd Etirephon Plant Regulator lor Colton will accelerate opening 01 mature unopened colton bolls and enhance deloliation 

which can result in earlier harvest with an increased recoverable yield. PREP'~ brand Elhcpllon treatment allows increased elliciency Irom a oncc·over 

harvest 

Some premature drop 01 smalt immature holls may be associated with treatment Do not apply belore sulfrdent, mature, unopened botts have 

developed to produce the desired yield 01 colton, 

A boll is mature when it is too hard to be dented when squeezed between thumb and lingers, too hard 10 be sliced with a sharp knile, and when the 

seed coat betomes light brown in color. 

For best results, thorough and unilorm sprily coverage is required. It is essential that the bolls are contacted by the spray to obtain optimum boll 

opening. Observe treated lields closely. Harvest at optimun boll opening and detoliation, generally 14 to 21 days alter treatment. Sustained cold 

weather with average day and night temperatures 01 6S"F or lower alter treatment with PREP'~ brand Ethepllon will delay the boll opening response. 

DO NOT APPLY PREP'~ BRAND ETHEPHON tF RAIN 15 EXPEGm WtTHtN G HOURS. Rainlali wilhin G hours of application may reduce pro(hlct 

periornlancc. 

(ertilied colton seed growers stlould observe bolt and seed Inaturity belore treatment with PREP'~ brand Etlrephon. Bolls not completely mature might 

open with treatment 01 PREP'~ giving lower quality seed, 

tMPORTANT: Do not apply PREP'· brand Ethephon ttl rough any type 01 irrigation ~tem. 

SPRAY PREPARATION 

Add 1/2 to 3/4 01 the reqrrired amoullt 01 water to the spray tank. Start agitation. Add the required ilmount 01 PREP'~ brand Ethephon, and the 

remilining amollnt 01 water. Preparc only as much spray solution as can be used on the dayol mixing. Do not altow spray solution to stand overnight. 

_0 not spilt the concentrateri product orr spray equipment. or any ,1irplane parts. ANY SPILLS SHOULD BE RtNSED tMMEDIATELY WITH PLENlY OF 

.,ATER. 

Use 01 a nurse tank is highly recommended lor avoiding possihle spills 01 COlrcentrated lorrmrlation on spray equipment or any airplane parts. 

EQUIPMENT ClEANING 

Spray deposits 01 PREP'~ brand Etilephon , when Ielt on aireral! acrylic plastic type windshields lor longer than 1 hour, may react with this material, 

larming an opaque tilm or spots on the surface I'of1 ich cannot be removed by wastfmg with water or any other deaner. Rinse windshields wi1h water 

immediately alter each tankload 01 PREP'" has been applied. Thoroughly rinse the aircraft with clean water alter each day PREP'~ is applied. 

PREP'" brand Ethephon may also altC{t certain paints, and if accidental deposits on painted objects such as cars, trucks, agricultural equipment, etc. 

occurs, these objects should be rinsed with water as soon as possible (within 1 hour) to prevent perrnanent staining of the painted surface. 

Because of the acidic nature olthis product, prolonged eXPQsure to spray deposit witt damage acrylic plastics, certain paints, and metals, 

Rinse thoroughly with a detergent and water all exposed aCf)'liL plastic·type materials (e.g .. aircraft windShields), and painted surfaces within an hour 

after exposure to spray deposits. At the end 01 each day rinse thoroughly with a detergent and water all the metal parts of the aircraft and the 

associated spray-equipment exposed to the spray deposits. 

BOll OPENtNG 

CfiNotTtDNS EXPEGED 

·7 DAYS AFTER PREP'~ 

TREATMENT QUARTS/ACRE 

Hot and dry BO'F or higher 1.0 (1.0 Ib ili) 

Of)' with temperature l.S(1.5lba.i.) 

7S'F to BO·F 

Cool bllt higher than (SF 2.0 {2.0 Ib ai} 

Rank cotton 2.0 (2.0 Ib a.L) 

Rates For Boll Opening 

ONE GALLON 

OF PREP'~ 

TREATS 

'1 Acres 

2,5 Acres 

2 Acres 

2 Acres 

SPRAY VOLUME 

GAL/ACRE 

GROUND AIR 

15t050 2toS'"" 

tSt050 2toS* 

)St050 2toS* 

25t050 5 

*NDT[: For Calilornia and Arizona use a volume 01 no less tharr 5 gilttons per acre lor ,1eriill ~tlpticatiorrs 

••• Time of Application (Boll Opening) • ••••• • ••••• 

Apply when there are sulficient mature unopened bolls 10 produce the desired yield, but no later than when 6~f t~e iolls are optned (see General 

tntorrnation section on how to test lor boll maturity). Do rrot tank rnix PREP'· brand Ethephon with a desiccant il therOllon is to he mi",rlle harvested. .. .... . . ..---..• " 

•• • 

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23 
, 

. PRECONDITIONtNG fOR DEfOLIATION 

CONDtTlONS EXPEOEO 

5-7 DAYS AFTER 

TREATMENT 

Hot and dry 80'F or higher 

Coof but higher than oS'and 

afso for rank cotton 

Rates for Precondftioning For Defoliation 

PREP'~ 

QUARTS/ACRE 

05 (05 fb ai) 

1.0 (1.0 Ib ail 

ONE GALLON 

OF PREP'~ 

TREATS 

B Acres 

4 Acres 

SPRAY VOlUME 

GAL/ACRF 

GROUND AtR 

1St050 2toS* 

t5toSO 2105* 

*NOTE: For California imd Arizona us.c<l vofume of no Icss than 5 gaffons per acrc for aeriaf appfi(ations, 

Time of Appfication (Preconditioning} 

Appfy PREP'W brand Ethephon 4 to 7 days prior to appfication of defofiant or tank mixed with the defoliant (see section on Compatibifity). 00 not tank 

mix PREP'w with desiccants unfess pfant desiccation is required, 

Pre-treatment With Defofiants PriOr to PREP'" Treatment 

If the cotton is overfy rank or faying down iu the mirfdfes and good sprilY coverage of the hoffs with PREP'~ brtHld [thephon is difficult. a prelrealmenl 

with defofiants wiff be usefuf to improve boff coverage with PREP'w. Use dosage rates of PREP'" recommended for boff opening. Read and observe aft 

.ppropriate filbef use directio11s and precautions for the rfefofiant used. 

Wo not use a defofiant before there are sufficie11t mature ullopened bofts to produce the desired yield (see Generaf tnformation se(~on on how til test 

for Boff Maturity). 

COMPATIBtllTY 

PREP'" brand Ethephon is compatible with OEr, FOLEX, DROPP, t-tARVADE, MUl-IYL P,\MTI-IION, GUTHtON AND MAlATHION, and may be appfied in 

sequence or as a tank mixture (DO NOT TANK MtX WtTH DEFOLIANTS OR lJEStCCANTS tN CAUFORNtAAND ARIZONA). tn some cases sfight reduction i11 

boll opening response has betn observed when tank mixes with rfefoliants were used, 

Good agitation in the spray tank is esse11tiaf and a tank mi:dtlrc shoulrf nol be allowed to Sland without agitatio11 for more than S to to minutes. Read 

and observe aU appropriate fabel uS{' dire(lions and precautions lor the defofiants and inS{'(ticides used. 

PRECAUTION: 

NOTE: UNDER CERTAtN CONDITIONS, TANK MIXTURES or PREP'W BRAND ElHEPHON WtTH OESt(CANTS CONTAINING SODIUM CHlORATE COULD RESULT 

tN THE FORMATfON OF HYPO(lILOROUSACIDS WI-HCl-l ON ItFATING WILL EMIT TOXIC CHLORIDE FUMES. 

DO NOT MIX PREP'w BRAND Ell-lEPI-ION WITH AMMONIUM THIOSULFME. StKH TANK MtXTURES MAY RESULT tN FORMATION OFroXIC FUMES. 

WHEN TO HARVEST: 

Do not harvest cotton sooner than 7 days after a treatment with PREP'W hrand Ethephon. Obselve the trl'atl.'d crop il11d harvest when optimum boft 

.illipeni11g has been reached_ Too early harvest might retfuw the fulf advantage of the treatlnent dnd too fate a hillvest may resuft in reduced quafity and 

wssof fint which wiff drop from the plan!. 

USE LIMITATIONS 

Do not exceed a maximum of 2,0 tb, ethcphon active ingredient per acre per year thr011gh combined or repeated uses of any ethephon products. 

Boll opening: Do not tank mix PREP'w brand Ethephon with a desiccant if the cotton is to be spindfe harvested. 

Pre·Condition for Defofiation: Do not tank mix PREP'w brand Ethephon with desiccants unfess pfant desiccation is required. Do not uS{' a defofiant 

before there is sufficient malure U110pened boffs to produce the desired yield (see Generaf Information section on how to test for holf maturity, 

Do not pfant another (rOil within 30 days ilfter treaunen!. 

USE PRECAUTIONS 

Avoid spray drift to nearby crops as this product wiff cause morfificatiom in p~1nt growth, Pfant inj11ry or reduced yiefds will resuft... • 

Mix onfy the amount of spray you e~pect to U5e each day. Do not alfow mixed sohJ1ion to stand ovemight • ••••• 

• •• • •• • • 

•••••• 

• • 

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••• •• • • 

• ... • • 

• 

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• 

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• ••• 

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24 
r------------.-~~~~~~-~~~~-- ~ 

, 

IMPORTANT: READ BEFORE USE 

Read the entire Directions lor Use, Conditions, Disclaimer 01 Warranties aud Limitations of Liability before using this product. 1/ terms are not 

acceptable, return the unopened product container at oncC. 

By using this produd. user or buyer accepts the following Conditions, Disclaimer 01 Warranties and Limitations of Liability, 

CONDITIONS: The directions lor use 01 this proriU(\ are believed to be adequate and sholiid be lollowed carefully. However, it is impossible to eliminate 

all risks associated with the use 01 this product Crop injury, ineffectiveness or other unintended consequences may result be<auw: 01 such factors as 

weather ronditions, presence 01 otlier materials. or the manner 01 use or application, all alwhich are bCy<lnd the control of Aventis CropScience. All 

such risks shall be assumed hy the user or buyt.'(, 

DISCLAIMER OF WARRANTIES: AVENTIS CROPSCIENCE MAKES NO OTHER WARRANTIES, EXPRESS OR IMPLIED, OF MERCHANTABILITY OR OF FITNESS FOR A 

PARTICULAR PURPOSE OR OTHERWISE, THAT EXTEND BEYOND THE STATEMENTS MADE ON THtS LABEL No agent of Aventis CropScience is authorized to 

make any warranties beyond those contained herein or to modify the warranties contained herein. AVENTIS CROPSCIENCE DISCLAIMS ANY LIABILITY 

WHATSOEVER FOR SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OFTHIS PRODUa. 

LIMITATIONS OF LIABILITY: THE EXCLUSIVE REMEOYOF THE USER OR BUYER FOR ANY AND ALL lOSSES, INJURIES OR DAMAGES RESULTING FROM THE USE 

OR HANDLING OF nus PRODua, WHETUER IN CONTRAa, WARRANTY, TORT, NEGLIGENCE, STRtCT I.IABtI,IlY OR OTHERWISE. SHAll NOT EXCEED THE 

PURCHASE PRICE PAtD, OR AT AVENTtS CROPSCt[NCE'S malON. THE REPlACEMENT OF PRODUCT . 

.. 

• 

Aventis CropSciencc USA LP 

P.O. Box 12014, Z T.W. AlexanderDrive 

Research Triangle Park, North carolina 27709 

PREP is a trademark 01 the Aventis Group. 

PREP'" brand Ethephon Plan! Regulator lor Cotton (pENDING) Slrbnlitted 7/17/02. 

•••••• • •• 

• •• • • 

•••••• 

• • • .. • 

••• •• 

• • • • •••• • 

... 

• ... •• 

• 

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• 

• ••• • .. •• . 

• 

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• • •••• 

.. . •• • · .. 

25 
Aventis CropScience 

August 12, 2002 

Document Processing Desk (AMEND) 

Office of Pesticide Programs (7504C) 

U. S. Environmental Protection Agency 

Room 266A, Crystal Mall 2 

1921 Jefferson Davis Highway 

Arlington, VA 22202-4501 

Attn: Ms, Cynthia Giles-Parker (pM Team 22) 

• Sub: PREP brand Ethephon Plant Regulator for Cotton (EPA Reg. No. 264-380) 

Revised First Aid Statement 

Dear Ms. Giles-Parker: 

1 am submitting an amended label for PREP brand Ethephon Plant Regulator for Cotton (EPA 

Reg. No. 264-380) in order to comply with the directions set forth in the PR Notice 2001-1 (First 

Aid). 

This submission contains the following documents: 

I. An application for new registration/amendment (Fonn 8570-1) [1 copy) 

2. Amended label for PREP brand Ethephon Plant Regulator for Cotton [5 copies) 

tit If you should have any questions, please contact me at (919) 549-2302. 

Sincerely yours, 

8n-~>-J' h«,_ Prasad Rao --

Registration Manager 

E-mail P.r;):".;}.d .. fil {1@a:-".~n! i.S._'::D lJ1] 

• ••••• 

• •• 

• •• • • 

••••• • 

• • 

• • 

•• 

••• •• • • 

• • ••••• 

Avcnlis CwpSdence· 2 TW Akxumjcf Drive· Rc~~arch l~~IJ P.fra Ne 2770')· WWlv.us . .:rop~clcRct",ave!Uis.com 

••• • •• •• • 

• 

• • •••••• 

• 

• ••• • •• 

•• • 

• 

• ••• • • •••• 

•• • •• • 

• •• 

Telcphonc (!JI()) 549 2000 26 
-

, 

,..;_ ...... , , Fo ,., '8 0"'. 

United Stet .. Registration OPP Montin., Humber 

.oEPA Environmental Protoction Agency ~ Amendment 

W .. hington. OC 204&0 Other :l<Z.;J.£'CfS 

== 

, for - II 

• Company/Produci Number 2. EPA Product tMnooer 3. Pfopotod Cluofflcatlon 

" "'" D- O RUlricted 

'PREP~biiind' "N~J Plant PM, 

Cotton 22 

5. u.n. end Add,.,. of Applicant {1tIchrd. ZIP Cow{ 6. Expedited Revetw. In a~ordaOCCt with AFRA Section 3{clt3} 

Aventis CropScience ~~l(il. mV product is similar or identical in composition and labeling 

P.O. Box 12014. 2 T.W. Alexander Drive to: 

Research Triangle Park, NC 27709 EPA Reg. No. 

D Ch.cJc H th# 1$ • m,w tIdt:Iru$ Product Name 

I - II 

El Amendment - Explain below. U Fin" printed l.tato In replOntll 10 

r= Agoncv filUM dlltid 

RHUbmlleion In f'"POn •• to AlJ!lncy letter dOlO<! o "M. Too~ Application. 

fi Notlfimion - £l(J)l8in bltlow. o Othe,- Explain below. 

Un additional p~I.1 lr n.c •••• ry. IFor .. ction I and Section 11.1 

Revised riff>! Aid $G(;tion of the label to comply with PR Notice 2001-1. 

-J!!. 

I'·M ...... ,..,,"' ....... - .. ,In, 

Child·R .. ilhint P~nO 

rI ~ Soluble P.ckeoino 2. Type of Cant.~r Bv" V .. V •• 

No I- No - g~'. Plntio No 

• CtirtJfICIJtJon must ~~~ .. ' No.,., ~·V"· ~o,.''' I~:~ wbmItI«I WQI. w" oOllwner 

, oil 

[J 

J n ... I 5

l J ' of J.oboJ 'u .... 8. Mllnner in Which Labelle Affielld ra Produot 

D~;:'3j~ D "' .... 

, -IV 

1. CO"", ""'" 

IN;,::'"", """ "0. Ttl~ No. {lncWde Ar .. Cadtl 

Manager 

CertHication •••••• 

I certity that the etltllfl'lllnil I hayti m«I. on thie fonn and all attaetwnanle thereto era tNa, /IOcume and ~ .. .:. 

Is. 

I ecJmowllKlge thet any knowlingllv fal .. or misleading elllrllfl'lllnt mtlV be puniehWIe bV fine or impriuM'lOffl: or • • b~ lew. ..: •• : .. •• • 

2. Si{fnatur. D I" " •• .. • ... .c P-.,q", • •• Rcglstratlon Mananger ••••• .. • ,~ 

. :. • - • • 

10. 0 ... •••• 

l"p~V:; ~::: • • 

August 12, 2002 •••• 

r .. :-

I W;;;;-.IPA , "",,v v- I27 
.,....---,_.-.... ~ -- .. - . 

• . f •• 

Ul'lllod $181ee r- Registration opp Idontifior Numbltf 

oEPA Environmentsi' Protection Agency I- Amendment .282593 .' . ,\Vo'Nngton, BC-;04BO I-- Other 

dor 1 ". 

11. eomplnylProduct Nuinb.r 1'2. EPA Pr'ciduet Marmoor 3. Propcaod Cfauif"teltion 

4. Company/Product (Nllmo) .. ' PM' D~OM D Retlnoled 

5. Name and Addr ... of Applicant Ccds} 6. Expedited Review. In accordance Section 3(c)(3) 

IbW), my product Is similar or identical!" , 

t., .// 

EPA Reg. No. , 

D Product Name / .,', 

\ " , - II ,' ... " .- " " , 

~ Amondment· Explain below, \ 0 ""'" in '''pOM. to , 

Rosubmlnion In r"ponn to Agency lotter dotltd !: .-

NotIlioation· Explain below. \ [( "m?" 

explanation: Uoe 'additional pag'!s) II nDoanery. (For :;eotion I .nd u~// 

.-

,/ 

./ Section -III \ " 

, ... \ ,.,. 

Child·Roristanl Packaging 

,- /// r \ 

2. Typo of Container 

BV"- V .. V ..l- f- N. §~W PIntle N. N. GIn. 

r- must ~;.v!,-, /~"', No. p~r '~~. wOt No, pst \ Pepor 

contlllner contain.r 1\ Othor / I 

!3D ,.Ii 

0 / 14, SO,{" .0<' 

E::l I~." 

..... en: 

6. Mannor in Which l.alal i:_lfflXed to Product 

~~ o 0'"" \ 

! , -IV \ 

1. Co",,, .~" 'fM' , .. , 

N_ Ind, No. Iinciude Areo Cc>do) 

Certification 6. Oato Application 

I oertify that tho ot&tomonts I havo mado on thiidorm and all attachmants '~.toto .ro true. oocur,u. and compl"o. Rooelved 

I acknowledg. thot any knowingly falao or misloadinG stall1mont may bo puni,h.-bk by fine or impritonmont w (Stamped) 

both undor apprlCablo lew. -

3. TItle 

_ 4. Typed NtImtI 5.0ato 

~ 

,8570·t ,.",8-04' , Whhf, • EPA FYe Copy (original) Cop, 
-----~ .. ~ .~~-~-

• 

PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

~:~~~~~~~g~~~~~~ Ar:~T~~~~~~;Pu~b"C reporting burden lor thhl: oOlleotJon of informotfon io "limatod to overoge 0,85 hour p.l . ,~mo f~~ I oxlstJng dato "QUrcCJ$. Oltherlng and maintaining tho data needod, ¥od comploting and 

col/eclion of Information. Send ,.gordlng the burdon "timet. Of any other •• peet of thiS' (lolloction of inform.riDn, including 

r.duclng this burden, to Chi.f, rnformatlon Pottey StoMh, 121361. V.S. En1lfrol'll1\ontaf Protoction Agenoy. 401 M Street. SW, 

DC 204(10. 

~~~~~:::;:'Thia form la to be uud lot all .pp~o.tion5 for now r4tlisttation, end {Jiltl retogl'ttlltion. atnol'ldmont, rOllubmission. to applic.uons 

for I I • final printed lebllling, rorogistration, Itc. In ordor to proco:s In application for ill now '.Ol.lt.tion wbmlUed on thi. form, the 

eocomplny tlul epp{iootion: 

1. CortirlCfltion with Resped to Citation of OatalEPA Form 8570-29). III not exempted by 40 CFR 152.tf1 (b) (4)); 

2. Confidential SUlt_nt of FOlTTIUle {EPA Form 3570-.. /; 

3. Fonnulator'. Exemption Stetement (EPA Form 8570-2.7); 

... Rve oopi •• of drah laI»IIng; 

5. ThfN GOpIn of any d.t8 eubmittod: 

6. Authorilation lener where appllcabl.; 

7. Matrioes whera applicable. 

I~'~:~:~~ of Labenna - LabrUing .hould first be .ubmittad In tho lorm of draft lebote with all eppncatioM for raw regi.tratlon. Such dreh label. mey be 

Ii of typed label text on 8.5 l! 11 Inch piper for eubmlpjon or e mockup of tho propoNd lebel. II praplJl.ci for mockup. It .hould be 

constructed in a way AS to fecillt.to .toreoe in an 8.5 x 11 inch file. Mockup lebols signiflcanUy smillaf than 8.5 X' 11 lnehoe should be mounted on 8.5 

x 11 inch papar for 'ubmiuion. 

Submiulon of Data - Data INbmiued in ,upport of till' app~eation mullt bo lubmined in ecoordenca with PR Notice 86-5. 

~t~~~~~~~~~:~:;p~,.~a." raed the In,truction,lillted below before completing thill opplioetion. Firllt detormilWl the type of 1~,~o~,_Ii_rA.e:J in Block A. for ere .ubmitting this epplication, For oppUcatlonllllubmined in conneotion with New Rogi.ttation actlol'\S, Sactiol'\t 

I, III, Ind IV muet be ~y IIJIPlicent. For eppncations submlttctd In oonneetion with amond.ci roregi:mation actiOnll. reaubmilt!oM, 

1 =_ti:cetionll. reregistr(ltion., otc .. Soc lions I, n, and IV mu,t ba completed by tho eppUcent. 

I .......... A - Check tha approprl.te action for which you ere submItting this form. 

l~iliJ;Illl!i'll: Thi. 8aclion must be complatod, ell epplicable, for all ragi'tration oction •• 

1. CotnpenylPtoduc:t Numbar • Insert your Company Numbar, if ona has baen aullfl'l8d by EPA. Thi. rwmber may hove bun euignod' ta yO\! as 0 

basic ragi.trant •• di.tributor. or all 1m esteblishmant. II your product i. ragistared.lnurt the Producr Numbor. 

2. EPA Product Manager· If known, ml in the namo and PM number 01 tm., EPA Product ManQgu. 

3. PropOMd Clanlflcetion· Spocify the proposed elnuifloatlon of this product. 

4, Product NarM • Entor tho complllta product name of this pes tic Ida as It wUI appear on the lobet. Tha name mull bo epaoifio to thia product onlV. 

Ouplieation of natnOI il rwt permittad among products of tho .amll company. Do not include any brend name or cOmpany line dosignations. 

5. NOrM and Addr ... nl Applieont· The nama of tho firm or perllon and addrass .hown in your opp~cotion is tho penton or firm to whom tho 

r.g1ltrntion will ba i1f5ued. If you aro actlng in behBlI 01 anothar party, you mu.t $ubmlt authorizalion Irom thllt party to act for dam in rag1.lta!lon 

rrumare. An appUcant not toeiding in tho United Stoltl, mu.t hove an authorized llQont rO$iding in the Unitad State. to let for them In ell 

rlgiatrotion matturl. Tho nnmu.nd compllta mailing addros.; of $\lch on Dgont mu.t Itltlomplny this application. 

6. Expldiled Roview· flFRA netion 3 Ie) 3 lSI pr(>vidas for oxpedited rawow of applle.t!on$ lor ragiJtration, or amendmontJ to existing rogiltrlltiOtili;. 

thot .ro oimllor or identical to (ltlmr pellticidl ptoduetJ thlt Irl ourrently ragist.red with tM EPA. In order for your app!lcltian to btl Dligiblo for 

a:quMlited raviaw, you must prome UI with tho EPA Regl1l11rntion Numb,r and product nllmO of tho product you baliova Is iJ1miler to or Idlnticol 

your product, The product /T1I.Hrt bo llimilar or idontical in both formulation and lablllod us ••. 

!~~~~~I~ II- Thielo.ctlon mu" be oomplelad for alt app1itllltiona IIUt>mltI'Id 10 omand tha regillUation only of. eurrantly ragi.tarod product 

for. r8$ubmiasion In reaponlla to an Agtumy I'tt,r. for notificlltinnll to tho Agancy, for the lIubmiulon of final printed labetllnll. for 

and for Iny othlr action that pllrtllins to a spllCific EPA-raWstllrad producl. Thi ... etlon f.!l!U 12 1m Uled far a now appIioation for 

t. Subjec:t of. eubmt.cion· Chock tho applicllble block end provide the Agency letter dOlO If IIPpropriot8. Provide a brial a)(planatlon of me purpOIIISI 

for tim eubmi.$ion. such II' ""the ilddition of a $lte. past or crop Izpacily)-; "IImIInd the Conlidel'ltiol Stotement 01 Formula by .. ."; ""rerogi,ltetion 

wbmiHlon""; -OIIl"H1rallllbel ravisian of usc diraotiornl.- Att&ch 0 eaperate paoa II odditiofWillpaee is needed. 

1111 and Container Inlormlillon) - This SeClion must bo completed for all IIPplicQtions: submitted in connaetion With new 

~ .. ble amendments. 

1. Type of P .... oglng • Chock tho flppropriullI block if your product will be pllCkagad in thaindicaled pockaging typeii'. 

Indlcatl the allO of the individual Pflt:!<:IIIli: find number per ratllil contuin~r. 

2. Type of R.taII Container· Indi¢eto typD ot contilin.r in which prGd\lct win be merkOtod. 

3. Locatlon of Net Centantt- IndIcate tho loclltlon of tM net contentt Information lor your product. 

4. Sin{.l of ReUlil ContliMr· Specily tho net contonts of l1li retail contelrl(lrs lor yout product. 

S. Locetion of u.:. Dittctlont· Indicate the 10cQtion of tho use diroctions lor your product. 

6. MInner In which lebtl. efftud to product - Indicated the method product lebel is attachod to retail conteiner. 

~:,~~I!! IV~ ICont.ct Pointl - Thie Section muli't be oomplutlld for all application. tor Rogistration ections. i.a .. new producto regisuotion. 

""me-tot,. "" ror.gi.ltlltlon. alC. 

t·S. SeU .. xplunatory. 

6. EPA U.a Only. 
, 

PREpTM brand Ethephon 

PLANT REGULATOR FOR COTTON 

FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. 

NOT FOR RESIDENTIAL USE. 

AUIVE INGREDIENT: 

Ethephon (2-chloroelhylj phosphonic acid'" .. " .......... , .................. " .. " 

INERT INGREDIENTS: ................................................... , ..................... . 

wTllis product contains 4 pountls ellieplion per gallon. 

..................... 39.9% 

..................... 60.1% 

EPA Reg. No. 264-380 EPA Est. No. 264-PA-Ol 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

Si llSl!~(1 no enliende la etirtlleta, husqllc a alguien para que sc la expllqllc a usted en detalle. 

• 

(II YOII do not llllder~lamJ the label, lind someone to explain it to yOIl in detail.) "et 

For MEDICAL And TRANSPORTATION Emergencies ONLY call 24 Hours A Day '-800-334-7577 ~>"f"::?v~ For PRODua USE Information (aIl1-888·AVENTIS (HJ88·283·6847) "I -,;:, . If - ;:;OO-33.'i-'17'f5 

rhe use 01 tllb producl lor a variely of plant growlh regula lion uses i~ covered by Uniled Slate~ and lorcign patenh illduding 

u.s. Patenl 4,240,819. No Ijc('nse is granl('d 10 use this product in collnlries olher than Ihe Uuile<l Slates or lor any lISe nol conlemplaleti by this labeL 

liabilily lor patenl iniringeillent Illay resull Irom use or !t<lle 01 this product outside the United Slate~. 

IF IN £YES: 

IFON~f(IN OR 

TO Ii 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS •••••• 

• •• 

••• 

• •• ••• 

• •• • (orro~ve_ (allses irreversible eye damage and skin irnlallon. Ilannhil il ~williowed or absorherl Ihrollgh skin. Do '101 get'll eyes..on ~ill. or on 

dolhing. 

ilarmlul or falal if ~walloweri. "voirl wolalillnalion 01 food_ 

•••••• • • • • •• 

••••• 

• • • • ••••• 

• ••••• 

• 

•••• • •• •• • 

• 

• ••• • • •••• 

•• • 

•• • • •• 
~~ . .....l e "f CV'.-°f ""~I' M> 0 f' ~e-v-:.,J PERSONAL PROTECTIVE EQUIPMENT (PPEj .. i . . . Applicators and other handlers mllsl wear IOllg·sleeverl shirt ilnd long pants, ChemlGll reSIS\iml gloves (weh as NlinJe, Bulyl, Neoprene and/or Barner 

lilmillJte). slloes plus socks and proleclive eyewear. 

when handlers lise dosed systems, enclosed cabs. or ahuaft in il manner thai meets llie requircmcnls lisled in the Worker Proleclion Slinufani (WflS) 

Jor agriwUural peslicfde~]40 erR 170240 (d) (+6}j, Ihe hanrJler prE reql]lfemenls may he reduced or modilied as sfle{ified in til(' WI'S 

DisGHd <lathing and olher absorbent materials that have been drenched or hNVily (Qlliaminaled with Ihis prorlu(t's wn(cnlrale. Do nol (,lISe them. 

follow manufadllrer's inslrnClions lor deaning/mainlilining prE. If no sudl instructions lor wasllahles, uS(> detergent ami hot water. Keep and wash 

PPE ~eparatcly Irom other laUllury, 

User Safety Recommendations 

Users should wash hands belore ealius. rtrinklllg. dlCwlllg gum, using tob.1«O or using Ihe toilel. 

Users should remove dolhing immerlialely if pesticiLie gets inside. I heu wil,>h thoroughly and plrl on c]e,ln dothing. 

USers should remove PPE imrnerliateiy after handling thj~ produ(\. /\'0 soon as po,>slble, w,1'>h Ihoronghly anrl chanb'<' inlo dean dolhing. Wash the 

outside 01 gloves belore rentovin)!. 

ENVIRONMENTAL HAZARD 

Avoid '>pray drill to nearby crops as Ihis pruducl mJy calise temporary modificalion,> in plant growlii. Do not conlaminate water nsed for irrigatioll or 

domestic purposes. 

Do IIOt apply directly 10 watel, or to areas where surface waler I'> present or to illtertidal areas helmv tile mean fliglllv,lter mmk. Do not (Qnlaminate 

water when dispo,>ing 01 equipmenllVashwaters. 

~ not exceerl tile rate 01 PI![P'~ br,uld 1:IIIepiiOil Plalll Regulator lor (olton per aae per year recommended on Illislabel. 

SPRAY DRIFT 

Avoid spray drill. Do nol apply when we,lther condilion,> may cause drill. Do nol (lilow Ihi'> produ([ to rlrift ou to non-target areas. Drilt may re,>ull in 

illegal residUes or iufnry to adiacenl (lOfIS (lnd "egelation, in Ihe form 01 leaf yellowing and deloliatioll. To ilvoid spray drill, DO NOT apply aerially 

wilen wiud speed is greater than to lIlph or dllring periods of temperature inwrsion'>. U'>e 01 larger droplet size will also reduce '>pray drill. 

AVOIDING SI'RAY DRIFr 1\ T THE I\t'I'LlCo\TiON SITE IS TIlE RfSPONSlBlUlY OF THE I\I'PLICATOR. 

1 he interaclion 01 mallY equipment'Jnd·weatJler·reJaled lactors deternline the potential lor '>pray drill. 1 he .1IlpliGl\or is re~pnnsilrle lor comirJering 

illlthe,>e factors when making deci,>iOlI~. 

1he foliolVing drill managernenl reqnirements mllst be followed to avoid olHargel movement lrom aerial applicalions to agricultnral lield (fOP'>. 

These rellirirements do nol apply 10 100e'>try applicatiollS, pnblic hC,lltfl Irsc'> or 10 application'> using dry lormulalions. 

1. The distance 01 the outer most nOllles ou the boom Illllstnot exceed 3/01 the lengtll 01 thcwingspan or rotor. 

2. N07.zles must always poinl hackwarrf parallel wilh the air stream and never be pointed dowmvard,> Inore Ihilll 45 degrees. 

Where stales h,lVe more Slringellt regulalions. Illcy shonld be ob'>er\'ed. 

1 he applicalor should be 1.1lnili,lr with anff 1,lkc hllo acconnt Ihe inlormalion covered in Ihe Aerial Drill RerhlcliOiI ArJvisory below: 

~RIAL DRIFT REDUCTION ADVISORY 

,.Ii'> seclion is advi,>ory in nature and doe,> 1101 ~uperseffe Ihe fll.1l1dalory lahel rertllirementsj. 

INFORMATION ON DROPLET SIZE 

rile IllOSt efJective way to r('allce drill polenti,ll is 10 apply large droplel,>, The be'>t drift rnanagelllelit strategy is to ilpply the large'>t rfrOlllet,> tflat 

I)rovide snlficient coverage ilnd conlro!. Applying larger droplet,> reduces drill potenliaJ. but will not prevent drill il .1PlrlicatiollS are llIade impropeay. 

01 nnder nnl.1vorahle ellvironmental cnmlitiom (See WlnrJ. remperiltnre and Iinmirfity. alllf Temperiltnre Inver'>ions). 

CONTROlliNG OROPLET SIZE 

Vohlflle· U'>e high flow rate n011les to ilpplj' the highest IlrJctic<l1 spr,ly vollnne. Noules with higher raled ilolVs produce larger droplets. 

I'ressure· Do nol exceed the noule lIIanllfaclurer's recommended pre~'>lIIe,>. rOr m,HIY nozzle type~ lower prC'>snre produce,> larger droplels. 

higher 1I0w rates are needed. (l'>C higfl('r 1I0\\' rail.' n071les in'>tead 01 increa,>ing pre,>,>\He. ., . Number 01 noules· Use the Inininlum nUllifier 01 nOllles IIlat provirle nniform coverage. • ••••• • ••••• 

Wilen 

Nozzle Orientation - Orienting nOZZles ill that the '>pray is releaser! parallel to Ihe airstream prodnces larger droplt1s th:n tther orien~tions and i'> the 

recommended practice. Significant deJJeClioll lrom horilonlal wilJ rednce droplet si7e and increase rJrift potential. •• •••••• • ••••• 

Nowe Type - Use a nonle type Ihal is designed lor Ihe inlcnded application. Wilh mosl noule Iype\ narrower spr<w an@lespro·ducelarger dropJels 

(omider I)sinll lOW-drift Iiouies. Solid ,tream nOllles oriented strai}lhl ]),ltk produce Ihe largestlfroplets and tile lowc,>t"d'rill. ..:.: 

••••• ••• BOOM LENGTH • • •• • 

For ,>olne (lse Ilallerns. reriliting tile elfettlve boom length to b,> than 3/4 01 the wing,>pan or rolor lellgtll Illay furil~er ·reduce Ilrifl.,,~ho(ll reducing 

swath wifUh •••••• 

•• • •• • • •• 

31 
APPLICATION HEfGHT 

APfificafions should not be made a! a height greater thilll -10 feel above tile lop of thelarget fdillltS uiliess il greater freiglr! is rertllirerJ for aircr;lft S<lfely. 

Maldllg applications al the lowest heightlllJI is safe rcrfll(cs expoSirre of drotdets 10 evaporation anrl !Vim!. 

SWATH ADJUSTMENT 

When appficatiol($ are marlc with a (fOSSWilld, the swath will be displaced downwind. "fIrcrelore, 011 tire lip .lInl rfolVnrvinrf edges of the field, Ihe 

applicator should COlflpensate for tlris rli~pla(ellient br adiU'>Iillg the path of lire aircraft 1I\lwilld. Swath ilffjusllllcnt distance should illcreasc. with 

illucasing rlrift potential (higher wim!. 'Smallcr ilrop\ etc.). 

WIND 

Drift potential is lowest between !Vim! sllcerfs of 2 . 10 Infrfr. However, many lilctors, incfllrfing droplet size and equipment type determille drift 

potel\tial at any given speed, Apflfkation shol1fd be avoirled bdow 2 mph doe to variahfe wind direction and high inversioll potential. NOTE: local 

terrain can inffuence wind pafterns. Every af1plicator sholild he lililliliilr with lo(af lVinrJ palterns (lild how tlley affect sfJfay rfrifL 

TEMPERATURE AND HUMfDfTY 

When making applications ill low relative hllillidity, sct Ufl equipilielit to prorlu~e filfger dropfets to collipensate lor evaporatioll. Droplet evaporatioll 

is Inost severe I'Ihen conditions are hoth hot amI riry. 

TEMPERATURE fNVERSfONS 

Applications sholild I\Ot oc(Ur during a temperilture inversiOIl because drift potential is high. T elllfJeratlire illversiolls restrict verticaf air mixing. which 

callscs slOan suspeorled droplets to relliaill ill iI con(enilated cfoud. This cfoud Cilll move in IInpredictahfe directions due to tile light vilfiable willds 

Wlltmon during inversions. Telilpewture iliversioliS are (haracterized by ill(fea~ing ten Iperiltures with aftitude and are commoll on nights with limited 

dOlld cover and light to no wind, They begin to lorm as the sun sets alld oftell colltillue into the mOffling. Their preserlce Ciln be indicated by ground 

log; however, il fog is not present, invNsions (an illso be idelltifierl by the Iliovenient of smoke lronl a glound S(lnrce or an ailCfaft smoke gellefatol . 

....ir0lie If\at layers and Inoves lateraffy ill a concentraterl !loud (undel fow wind cOllditions) indicates an inversion, while sUloke that nloves uf1ward and 

'llJPidly rfissip,ltes indicates good verti('11 air lIlixing. 

SENSfTfVE AREAS 

lhe pesticide should only be applierl when the potential lor drift to adjacent sensitive areas (e.g. residelltial areas, bodies 01 water, knol'm habitilt lor 

threatened or endangered sper.ies, non·target (rops) is It\inimill (e.g. wilen winrl is blowing away Irom the sellsitive areas). 

DlREalONS FOR USE 

tt is it violation of Federaf law to use this product in a manner inconsistent with its labeling. 

Do not apply this product in a way tha1 wifl contact workers or other persons, either directly or through drift_ Only protected handlers may 

be in the area during application. For any requirements specifiC to your State or Tribe, consuft the agency responsible for pesticide 

regulations. 

Read entire label before using thIs product, 

AGRICULTURAL USE REQUIREMENTS 

Use this prodllct only in ilccordallce with its laheling alld Ivifh the Worker Protectiun Standard, 40 CFR part 170. TIIis st.lIIilard colltains rcrillireifielits 

lor the protection of agriculturaf I\'orkers 011 farlllS, forests, lIurseries. and grecnhouses, afllf handlers of agrimifllr<ll pesticides. It rOlltains 

requiremellts for traillillg, rlecontalllin,ltion, lIotiliCiltion, ,1orl emergency 3ssistall(e. It alsO colltaills ~pecific instructions and exceptions pertaillin)lto 

the statelllcnts on this label about personill protective ('flilipillellt (PPE), notificatloll to \VOl kers and restricted·elltry interval. Tile reqilirelllcnts in this 

only apply to uses of this flfodllctthat MC covered by the WOIker Protectioll Standilfd. 

not enter or allow wOlker entry mto treillrr! ilreas dllring the rCsiricterf'(,lItry IIIterval (REI) 01 48 hOllrs. rhe REf is 72 homs ill areas rohere aver~ge 

i II is less than 2S Illdies per year. 

prE required lor early entry to treaterf Jfea~ thilt IS penllilted under the WOlker Protectioll Stallifanf and tllat involves 

been treater! such as tllants, wil or water i~ coveraffs over long·sfccved shirt alld long pants, (hemiGiI resistallt ,I""C\D£ 

dlcmicaf resistant footweilr flfliS socks, allr! protective eyelvear. ror overhead expoSllr(', dlemicaf-resistallt headgear i ",""",h"'" 

I f ,I I I 

" -; I~',,-,,,",-,,., t,-, .".; t- f) 

Do not contamillate Ivater, lood, or Iced Ily stor;lge or disposal. ,.......-/ 

•••••• • •• PESTICIDE DISPOSAL • •• 

• •• • 

Pesticirle wastes are acutefy flillarrlOils. ImplOpcr Ilisposal of excess pesticide, sprJy filixtille, or rillsate is a violafiol\ 01 lederal lill'I .• tI tll8':>(, wastes 

Cilnnot be disposed 01 by use accordill)l fo filbel instructions, COlltact yOllr Stilte Pesticide or EII~ironlnelital Control1.g~(Y:r tile I4UrMus Waste 

repres(,lltiltive at 1111: nearest EPA Regional Office for gllidance. • •• • • ••• • •• CONTAINER DISPOSAL 

Triple rillse (or I , ; the empty rontainer~ 

state,lnd loral 

, if 

I 

, , ••••• • • 

•• • 

•• • amI rlispo~tII trPa sanitaryJil~1Iill, or by 

• • 
,-----.-... - ..• ----. ------_._-----------------

GENERAL INFORMATION 

,\ foli,lr spray of PREP'" branrl Ethepliofl Plant Regulator for Colton will iI(CClerille opening of mature unopened cotton bolls ilOd enliance defoliation 

whidl an rest ill in earlier harvest with an increasel! recoverable yield. rREr'~ IU;lIIrl Ethephon treatmellt allows increased eliiciel1cy from a once-over 

harvest. 

Soille premahlre drop of ~lnall. imma\mc bolls Iliay he associalL-d with treatmellt. Do nol apply before sufficient, maim!', IInopened bolls have 

devefoped to prodllc€' the desired yield of cottOIl. 

A boll is mature wIlen it is 100 hard to be dented when squeezed betweell thumh and lingers, 100 hard to be sliced witll iI sharp knife, and when the 

seed coat becomes light brown in color. :.tV\. 

For best results, thorough and lmiform spray coverage is ren~d. II is essential that the bolls are conlacted by tile spray to obtain optimum boll 

opening. Observe trealed lields closely. Harvest at optimu6lboll ollening anrl defoliation, generally 14 to 21 days alter treatment. SlIsl~ined cold 

weather willi average rlay and night tenlpera!lJfes 01 65°F or loner alter treatment with PREP'~ hrand Etl1ephon will delay the boll opening response. 

00 NOT APPLY PREP'~ BRAND fTllEPIiON IF RAtN IS EXPEGW WITHtN 6 \lOURS. Railiiall withill 6 hours 01 application may reduce prodllct 

perlormance. 

(ertilied colton seed growers should observe boll ami seed mahlrity before treatmellt with PREP'~ brand Etflephon. Bolls not conlpletely mature migllt 

open with tre!ltment 01 PREP'~ givillg lower qllality seed. 

tMPORTANT: Do 110t apply PREP'~ bra nrl fthepllon through allY type of irr'lg<ltion syslem. 

SPRAY PREPARATION 

Add 1/2 to 3/4 01 the required amount 01 water to the sprilY tank Start agit!ltioll. Add the reqllired amollnt 01 PRfP'~ brand Ethephon. alld the 

remaining anlount 01 water. Prepare only a~ milch spray solution as can be used on thedayol mixing. 00 not aliowspray solution to stand ovemight. 

Do not spill the concentrilted product nn spray equipmellt. or i1ny airplilne parts. ANY SPillS SIIOUI.O liE RINSW IMMWIATElY WITH PLENTY OF 

.TER. 

"'!rse 01 a nllrse taflk is bighly reconllnended lor ,woiding possible s\1ills 01 (oncentrate(llormulatiOIl on spray eqllipment or any airpl;me parts. 

EQUIPMENT ClEANING 

SpfilY deposits of PREP'~ brand fthephon , wIlen lell on i1irerall acrylic plastic trpe windsllields lor 10flger than t Iiour, may react with IIlis material, 

lorming all opaque lilm or spots on the surface which cannot be removed by wa~hing with water or any other cle!lner. Rinse windshields with water 

immediately after eilch tankload 01 PREP'" has been applied. Thoroughly rinse the aircraft with clean water alter each dily PREP'~ is applied. 

PR[I"~ brand Etheplloll may also allect certain pail ItS, and II actitlelltal deposits 011 painter! ob[ects such as cars. trucks, agricultural equipmellt. etc. 

O((llrs, Ih(3e obiects should be rinserl witll willer as soon as pOSSible (witilin 1 Iiour) to prevent permanent staining 01 the paillted sur/aCl', 

Seallse 01 tile acidic nilture 01 this product, prolonged expO$llre to spray deposit will damage acrylic plastics, cert~in paints. anrllnetals, 

Rinse thoroughly wilh a detergent and water all exposed acrylic plastic-type materials (e.g., alreralt windshields), and paillted sllrlilccs within i1n lIour 

alter exposure 10 spray deposits. AI the end 01 each dilv, rinse Illoroughly with a detergellt arid water all the metal parts 01 the aircralt and tile 

associated sprily equipment exposed to the spray deposits. 

BOll OPENING 

Rates For 8011 Opening 

~NDtTtDNS EXPECTED ONE GALLON SI'RI\YVOI.UME 

DAYS AnER PREP'" OF PREP'~ GAl./ACRr. 

RfATMENT QUARTSjA(J{E TREATS GROtJND AIR 

Itot <lntl rtry 80'F or Iligher 1.0 (LO Ib a,i.) <11\cles 15 to SO 2 to 5'" 

OrylYitll temlleriltllre t.5 (1.51b a.i.) 2. 5 Aeres 15 to 50 2 to 5'" 

7S"F to OO"F 

Cool but higher tlliln 6s"r 2.0 (2.0 IIJ a.i.) 2 Acres f5 to SO 2 to 5* 

Rank cotton 2.0 (2.0 Ib iLl.) :2 i\Ul'S 25 to 50 5 

"'NOTE: Fnr Calilorllia aml,\riwna lise a vnlume 01 no less tlwi 5 gallons per am-:- lor aeri;!1 atltlliciltiol1s 

Time of Application (Boil Opening) ., . • •• • ••••• • •• 

Apply wilen tllere are slillitient malure IInopened holls to prodllce the desired ¥ield, bllt 110 later thiln when 60\'(01 tCe t'olls are oplOned (see GClleral 

Information section on IlOw to test lor bollmatllrity). Do not tank mix PREP'~ bralld Ethephon witll a deslccallt il tile colldh is to tie spiJldle h~lvcsted. 

•••••• • ••••• 

•• • • .. • 

••••• • • • • ••••• 

• ••• 

• .. •• . 

• 

• ••• • • •••• 

. 

.. , . . · .. 

33 
PRECONDITIONtNG FOR DEFOLIATION 

CONDITIONS fXPFOEO 

5·7 DAYS AFTER 

TREATMENT 

Ilot and dry 80"f. or higher 

Cool bllt higher than 65"lInd 

also for rank (otton 

Rlltes For Preconditio ning For Deloliation 

I'R[I"~ 

QUARTS/ACRE 

0.5(0.5Iba.i.) 

\.0 (1.0 Ib ai) 

ON[ GALLON 

or PREP'~ 

!REATS 

8 Acres 

.) ACles 

SPHAY VOLUMF 

(lAt JACRE 

GROIJNO ,\lR 

t5t050 2t05* 

t5t050 2t05* 

~NOIE: For Calilornia and Arizona nse<l volume 01 no les, liMn 5 gilliom per acre lor aerial Jflplicatiorls. 

Time of Application (Preconditioning) 

Apply PREP'~ brand Ethephon.) 10 7 days prior to irpplication 01 defoliarrt or tank mi~ed with the rlefoliarrt (see senion on CompatibiIiIY). Do not tank 

mix PREP'" with desiccants urrless pl<lrrl de~iccation is reqrrired_ 

Pre·treatment With Defoliants Prror to PREP'" Treatment 

II the cott011 is overly rank or la~'ing down in the mirldles arrd good slrray ccwerage 01 the bolls with PREP'· hrarrd Elhephon i, dilfiwlt, a pretrealnwrrt 

with defoliants will be uselul to improve boll coverage with I'RfP'". U>e do>age rates 01 PREI"~ recommended lor boll opening. Read and observe i111 

appropriate labt:'! use diredions and precllrrtiorrs for the deloli;mt rrsed, 

a.. not use a deloliant before there are slIlIicient 111atrrre unopened bolls to prodrrce the ricsired yield (see Generallrrlorrnation section on how(lIihesl 

....aro~ 0011 Maturity), ( 

COMPATIBILITY Yo 

PRtl"~ brilnd Ethephon is comp;!tible with Off, FOLEX, OROPP, tlARVADE, METHYl PAHAmION, GUfHION AND MAl.AlttlON, and way be applied ill 

set]rlence or as a tank m'rxtme (DO NOT TANK MtX WITI I Q[fOLlAN"lS OR DESICo.N1S IN G\UrDRNt,\ AND ARIZON,\), In some cases slighl redllCtion in 

boll operring rewonse hils beerr observed when tank rni~es with defoliants were userl. 

Good ilgitiltion in the spray tilnk is-esserrtial and a lank mixtrrre sh01lld not he allowed to staml withorrt agitiltion lor more than S 1010 rninntes, Rl:'ilfl 

ami observe ilil appropriilte label use direlliorrs ,rr1f1 prec;rutions lor lire rlcloliants ilnd inse<ticides used. 

PRECAUTION: 

NOTE: UNDER CERTAIN CONDITIONS, TANK MIXTURES OF PREI"~ BRANO ETIIEPIIDN WITII DESICCANTS CONTAINING SODIUM CIILORATE COULD RESULT 

tN TIlE fORMr\TiON Of HYPOCIHOROUSACIDS WttlCH ON tlFATING WILt [MIT TOXIC CitLORIOF fUMES. 

00 NOT MIX PREP'" BRAND lTI1EPliON WITH "'.l~IONtUI.t TI-lIOSUtfAl[ SUCH 1,\NK MIXl tJRf:S MAY RI:SUL T IN fORMATION anoxIc FUMf5. 

WHEN TO HARVEST: 

Do not halVest cotton sooner than 7 d~y5 after " treatment with PRr:P'~ braml f:theplron Observe the treated crop ami harvest when oplimunr boll 

opening has been reached. Too earlyhalVesl might reduce tire lull advarrta\W 01 the trealment and too late<l harve<,! rnay reslrlt in reduced qual'rty artd 

ass 01 lint whklr will drop Irom the plan\. 

~SE LIMITATIONS 

Do not exceerl iI maxinrrlm 01 2.0 111, ellreplrop aClive ingrediel1\ per aue per ~'eilr lhrouglr conrbined or retleilled r)scs 01 anydllephorr products, 

13011 Opelling: 00 110t tank nrix PREP'~ brand EthephoillVith a deSlccallt 11 the cottorr is In he spi11dle Ir<lr\'esterl. 

Pre,Conditioll lor Dclolialion: Do not t,1llk mix PREI"~ brand Ethephon with Jesic(ilnts llnless plant desiccation is req1lired. Do 1I0t 1fSC a defoliant 

helarc there is sl1l1iaent nlatrrre unopened bnlls tn produce tire desired yield (seC' General t(\lonn,l1ion settion un Irow to test lor holl rrriltrrrity. 

Do nOl pl~nt another crop witbin 30 days alter trealrnerrt, 

USE PRECAUTIONS 

Avoid spray drill to nearby crops as this product will (ause rnouilic,lIions ill plallt growth, Plant injury or r(!du(ed yields wrll resrrl!... • 

Mix orrly tire i>mount 01 sway YUII {'xpect tn rrsee.1fh rlay. Do 110t allow rrrixed solution to starrri owrnigh!. • ••••• • ••••• 

• •• • •• • • • 

•••••• • • • • •• 

••••• • • • • ••••• 

• • •••••• 

• 

• ••• • •• •• • 

• 

• ••• • • • ••• . ,. . , . • •• 

34 
• 

• 

• 

rr"Y" "LtMLl cD Wi'\f{Ri\ NT'-i 

IMPORTANT: READ BEFORE USE ~ 

AND 

Dr.$ CL-fl "Ltl-H' R. 'I 

Warrdn!ie$ and timilation$ 01 liability before using Jhj~ product II lerm$ are 

I Warranties and limitatlon$ of Llabillly\" 

Avenlis.CropScienceUSA lP -. cJ,,\'-Cl-':J~ r 1-0 J/v'\ ,,, R k--d .. , e - t>e;('vL:>vl. c A ~ G\.>\.-\.."fC-LV"I./ II 

P.o. Box 1201'1, 2 T.W. Alexander Drive ••• 

Research Triangle Park, North Carolina 27709 , • ••••• • ••••• 

PRFt'isillrilrienlilrkoftheAv('nti~Group,- J\A'~n1~~ rro ... ", "R H Ot-J E.- -rOlft l-:E tJ DIJ 

I'R[r'~ hland Hhephon l'lanl t1egulalor lor Cotton (PENDINC) Subm'llIl'{17/17J02- d\.-~,-~ e<l. •••••• • • • .. • 

••• •• • • • • ••••• 

• • •••••• 

• 

• ••• 

• .. •• . 

• 

• ••• • • •••• 

.. . . , . · .. 

35 
• 

• 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON. D.C. 20460 

08/21/2002 

PRASAD RAO 

AVENTIS CROPSCIENCE USA LP 

P.O. BOX 12014 

OFFICE OF 

PREVENTION, PESTICIDES AND 

TOXIC SUBSTANCES 

2 T.W. ALEXANDER DRIVE 

RESEARCH TRIANGLE PARK NC 27709 

PRODUCT NAME, PREP BRAND ETHEPHON PLANT REGULATOR FOR COTTON 

COMPANY NAME, AVENTIS CROPSCIENCE USA LP 

OPP IDENTIFICATION NUMBER, 282593 

EPA REGISTRATION NUMBER, 264-380 

EPA RECEIPT DATE, 08/15/2002 

SUBJECT, RECEIPT OF AMENDMENT 

DEAR REGISTRANT, 

The Office of Pesticide Programs 

for an amendment and it has passed 

completeness. 

has received your application 

an administrative screen for 

During the initial screen we determined that the application 

qualifies for fast track review. The package will now be forwarded 

to the Product Manager for review to determine its acceptability. 

If you have any questions, please contact C. GileS-Parker, 

Product Manager 22, at (703)-305-7740 . 

Sincerely, 

Front End Processing Staff 

Information Services Branch 

Program Management and Support Division 

Intemct Address (URl) • http://wWw.cpa.gov 

R~cycllldIR"",yclablll. Prlntod with VlIg~tablo au SaNd Ink. on Recycled P"POI (Minimum 50'1. Postconsumer content) 36 
FRONT ENU ... PROCESSlNG APPLICATION INFORMATION CImCT<: ClS'r 

PM cA ;2 

EPACOMPANTNUMBERd~ Y -;3S13 

EPA REGIBTRATION NUMBER STATUS 

(FOR AMENDMENTS) . '. , 

.. 

A~ 

. c------'-

CANCEI:r:ED 

NOT.INREFS:_~ 

, 

"ME-TOO" errED PRODUcr STATUS Aqr:rtr&, __ CANCELLED, __ 

NOTmREFS, __ _ 

• 

DATE %'c7!-z:;,;'L 

• 

37 
• 

APPLICATION FOR AMENDMENT 

WITH DATA 

lNlT. DATE 

FEU __ 

SIG(DATA) ____ _ 

PM 

NO DATA 

lNlT. 

FEU/:W' 

" 

PM /7'.2 

DATE 

OPP# ~2,V,,;;'7;-

38 
PESTICIDE REGISTRATION ACTION TRACKING SYSTEM (PRATS) CODING FORM 

BAR CODE, S6:217--:z:t ID NUMBER, :2.6'4-380 ACTION CODE, 30D , 

PM: 22 REVIEWER, BO! z..LA.l V\ DUE DATE, 1\ / 13. / 02. 

DATE ON APPLICATION: <t / 12-/0?-

EPA RECEIVED DATE, '3 / I,,,> / D?-

PM RECEIVED DATE, j I G I 02-

APPLICANT, AVfJ;,S C-'C±fS~e-v.ce-; PmS~ 13,9.0 

CHEM CODE (1), 09"1 '30 ( CHEM, ~E:'"=':li..JL!,)-"'errk..c:J4!-"'h'---_____ _ 

CHEM CODE (2), CHEM, _______________ _ 

DESCRIPTOR, f'BIJ 2-,Q<9[-( (E;'cst A~d) IcvbeJ ~3e.,S 

• DATA REVIEWS, 

HED, RCAB __ _ TB __ _ RCB, __ _ DRES __ _ 

OREB __ _ 

IO __ _ EEB __ _ EFGWB, __ _ ERCB __ _ 

BEAD, ACB __ _ BAB __ _ EAS, __ _ 

RSB, PCRS __ _ PRS __ _ PCS, __ _ 

PM Team: Carl __ _ Paul __ _ Vern, __ _ Bill ---

• FINAL ACTION, RESPONSE CODE, RESPONSE DATE, _1_1-

75-DAY RESPONSE: YES NO MOS, (1) CITE ALL 

CRP, YES NO (4 ) NOT APPLICABLE 

RESTRICTED USE: YES NO (S) SELECTIVE 

EXCLUSIVE USE: YES NO 

MANUFACTURING USE, YES NO 

CONDITIONAL REGISTRATION/UNCONDITIONAL REGISTRATION 

NOTES, 

39 
• 

• 

RHONE-POULENC -

RHONE-POULENC AG COIIPANY 

April 8. 1998 

United States EnvirOIln1t'Il1<l[ Protection Agency 

Office of Pesticide Programs 

Document Processing Dcsk(7505C) 

40 I M Street SW 

Washington D.C. 20460-000 I 

Attentim~: :"-'1£. Cyr.tI~;:1 Gile~*Pa!ker (PM No. 22) 

RE: FINISH !t Han'cst Aid for ClltiOn (EPA Reg. No. ~64*564) Cydanilide Technical (EP:\ 

Reg. :\0.26..\-565) and 011 Rhone Poulenc Elhcpholl Prmtllc\s (264-257. ~6"\-263. 264-267. ~6..j.· 

292. 26..1·]76.16 .. k;n. 264-3S0. 26,,\-,,\18.264-5 I land 26..\-5 .. 1-3 

This ieuer is to inli.1rm you 1h<l1 dllC to recent organizulionui changl's at Rhllne Pouicllc. I will no 

longer be handling registration issues all cyclanilide. FIl'.'ISI-I il: brand Harvest Aid l'Or Colton. or 

ethephon prodllcis. \'fr. Warren Davis will aSSlIme n::gul<nory responsibilities for cyclanilide and 

FINISllk:' He can b~ reaehl.,.<d at 919·549·2379. Mr. ;-,,'ick Somma will handle all cthcphon 

regl1latory issues. \:i.:k·s phone number is 919-549-2372. Please addr6s all rUt1lrc 

correspondel\ce [0 \:ick or W<1rr~n. YOII should I..."olllinll(, to lise the s<.1Inc lIIailing address 10 

n:ach Nick or \\·arn.::n. 

I havc enjoyed \\llrking wilb )011 and particularly appn:ciale all oI'your c\)Iltributiol1S 10 lhe 

Flt\ISH ~ regi~1ra\illl1 thi::. p~ISI year. I call ho .. ' n.:aciwd ~!1 919-549-26S"7 i r yml I!;l\ (' an~ qJll.'slions. 

Sino:reiv . 

.AUjJ~ Gail S. Po\\ell, Ph.D. 

Senior Registralion ~lanager 

PO BO;( 12{)lJ. 2 'U, A'_f:;(I<liG>.:R Dfl:VE 

RESEAR(;(-l TRIAhCLl PARi< r 1 C 2;70G-r:'~ 

(9191549·2000 

£xceffenC9 ,,1 ?erformance 

Pride in Achievement ItHEANATIOHAL lEtt:': JIU'.!Bi;Fl 4C19a:3~8-;'I.EWERRACi< !'PC RTP 

INTERNATlONl.( DISIHlfiVl:01 St:RVICf~, rt'_i! rjU!.'e~R ~;}S93!7.:._NSVi::f'B/,C"-.I.pc: <)~ 

40 
. u,s. ENVIRONMEr-..,.AL PROTECTION AGESCV EPA kg N~mbcr: D:nt ,,( 1",,3Di;~' 

.;~tOn-A-"t: orr"t of PcstlCide PIOg!'l.llli 

~gi,tnlk," Oivi';"m i1l7505C) 264-380 Jlt 17 1997 '111>", 401 OM" s(. sow. 

t~} W;I.\hinglOn. 0 C 11)1.61) 

Tam of h,u:lOCt': Unconditional 

NOTICE OF PESTICIDE, 

--- Registration 

_X_ Reregistration Name ,,( I'e::o;icidt I'nx!ul:t: Prep 

(Uootl FlFRA. :u amended) brand Ethephon plant 

Regulator for Cotton 

N;um, and Add,<::s~ ,,( R~giltr.Ul( iirn:lude ZIP Cootl: 

Rhone-Poulenc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, NC 27709-2014 

Nott: Changes in labc1ins differing in .ubs~ (rum WI..:ce;md in eontI«lion with thit fqisU'3lion I\'IlISI hi: ~ubl!liuW ro 3Il<.I ~ by the Rq:islIation 

Divif;ion prior 10 USt of the label in CQIIIIIlC\ec. In;my co~po~ O<l this producclllwBys rd ... 10 the;Wo~ EPA "'lisLrllloo lIIIrnbeT. 

On !he bad.! of inform.>lwn furnished b}' !he fQ:'lSlf.llll. the ,*",~t Il:1IIWd pellidd<- i< lie/roy rq:i1lCrcdlrtTq:is~rood under the Ped<Tal'lliedicWc, Fungicide:md 

• RO<kntiI:ide Act. 

Rqistr.llion is in no way 10 I>t """"Irut<!", ~n tndonemc:rn 01 rttOffilIlCfl<Wion of mis ",,>ducl by lhe Agency. In order 10 proo:.:t h ... hh;wi lbc CllvimllItl!:rn, 

the AdminiHl1l!Or, on his OIO\lon. In.!.y at lUly liJfl': IU~pt"nd 0/ clU}I;d the regislT~uon of a pt"Sliddc in acrocd1Lnce' wlm the Act. The;ICC~ of any rwuc: in 

COflMdion .... lm 11M: rq:isuation of ~ plDduu undcr \his ACI is 00110 be lOl'Ilnruro ;\S giving the regiSlfMI a rigb'i to uclmi,c use of lbc II:UI\C or to its USc If it 

Iw. b«n «'Wert<! by othm. 

Based on your response to the Reregistration Eligibility 

Document, EPA has reregistered the product listed above. Enclosed 

is a copy of your label stamped UAccepted. n This action is taken 

under the authority of section 4 (g) (2) Ie) of the Federal 

Insecticide, Rodenticide Act, as amended. Reregistration under 

this section does not eliminate the need for continual 

reassessment of pesticides. EPA may require submission of data at 

any time to maintain the registration of your product. 

• 

Sigr.:o!ull' of Applo'lng OfrKi:1l' lsi Owe: 

Jll. 17 1997 

41 
PRE PTM brand Ethephon 

PLANT REGULATOR FOR COTTON 

FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. 

NOT FOR RESIDENTIAL USE. 

ACTIVE INGREDIENT: 

Ethephon (2-chloroefhyl) phosphonic acid" .............................. , ...... , ............ " ............................ >< •••••••••••• 39.9% 

INERT INGREDIENTS: ........................................................................................................................... 60.1 % 

"This product contains 4 pounds ethephon per gallon. 

EPA Reg. No. 264~380 EPA Est. No. 264-PA-01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

Si usled no entiende la eliquela, busque a alguien para que se la explique a usled en delalle. 

(If you do not understand the label, find someone to explain illo you in delaiL) 

.nF'coirrIMilJ[eDpjjl C[AAi:L~AAin"dliTjjR~AilNVS~P~O[iiB~T~A~T~I~0~NQEfim".;;r~ge:enn:cC1i~e.SlQ:i'N~L~Y"cC~a~II-:2~4~H~o~u~r.itAn:Diii.~Y-,1f..:aBO:OO;;:.:a3a:344-."775if77;7r For PRODUCT.!J.S.E. Information Call 1-800-334-9745 

The use of fhis product lor a variefy 01 plant growth regulalion uses is covered by United States and foreign patents including 

U.S. Patent 4,240,819. No license is granted to use this product in countries other than the United States or for any use not 

contemplated by this label. Liability for patent Infringement may resu~ lrom use or sale of fhis product outside the United States, 

FIRST AID 

IF IN EYES: Hold eyelids open and lIush with a steady, gentle stream 01 water for at least 15 minutes. Get medical attention, 

preferably an Ophthalmologist. 

IF ON SKfN: Immediately wash with plenty of soap and water. Get medical attention. 

IF SWALLOWED; Do not Induce vomiting. Promptly drink a large quantity of milk, egg whites. gelalin solution or if these are not 

available. drink large quantities of water. Avoid alcohol. Call a physician or Poison Control Center. 

NOTE TO PHYSICtAN 

Treat symptomatically. Consideration should be given to the possibility that overexposure to materials other Ihan this product may 

.ave occurred. No specific antidote is available. Probable mucosal damage may contraindicate the use of gastriC lavage. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

Corrosive. Causes irreversible eye damage and skin irritation. Harmful if swallowed or absorbed through skin, Do not get In eyes. on 

skin, or on clothing. 

Harmful or tatal it swallowed. Avoid contamination of food. 

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and other handfers must wear long-sleeved shirt and long pants. chemical resistant gloves (such as Nitrile. Butyl. 

Neoprene and/or Barrier laminate). shoes plus socks and protective eyewear. : ••• 

When handlers use closed syslems, enclosed cabs, or aircraft in a manner that meets the requirements lisled in the \t<orker Protection 

Sfandard (WPS) for agricultural pestfcides {40 CFR 170.240 (d) (4-6)), the handler PPE requlreme~s .,.;a:~ be reduc~d or modified as 

specitied in the WPS. • • : ••• :. 

•••••• • Discard clothing and other absorbent materials that have been drenched or heavily contaminated wiftl'lhi" prod4PJ'§ corcenlrate. Do 

not reuse them. Follow manufacturer's Instrucfions for cleaning/maintaining PPE. If no such instrucJio£li for washables,.use detergent 

and hot water. Keep and wash PPE separafely from othar laundry. •• •• •• 

iACCEPTED 

JJl. 1 7 1997 

••••• • ... 

•• • •••• 

••• • 

•• .. 

42 
User Safety Recommendations 

Users should wash hands belore eating. drinking. chewing gum, using tobacco or using the toUet 

Users should remove clothing immediately if peslfcide gets Inside. Then wash thoroughly and put on clean clothing. 

Users should removo PPE immediately anor handling this product. As soon as possible. wash thoroughly and change into clean 

clothino, Wash the outside of aloves belore removina, 

ENVIRONMENTAL HAZARD 

Avoid spray drilt 10 nearby crops as this product may cause temporary modificaHons in planl growth. Do not contaminale waler used 

lor irrigation or domestic purposes. 

Do not apply dirocUy to waler, or 10 areas where surface water is present or to intertidal areas below the mean high water mark. Do not 

contaminate weIer when disposing of equipment washwalers. 

Do not exceed the rate of PREpl" brand Elhephon Plant Regufalor lor Cotton per acre per year recommended on this label. 

SPRAY DRIFT 

Avoid spray drift. Do not apply when weather condilions may cause drift. Do nol arlow this producl to drift on 10 non-targel areas. Drilt 

may resull in illegal residues or inrury 10 edjacent crops and vegelalion. in the lorm of leal yellowing and deloliaHon. To avoid spray 

drill, DO NOT apply aeriallY when wind speed is greater than 10 mph or during periods 01 temperature inversions. Use 01 larger droplet 

•

size will also reduce spray drill. 

AVOIDING SPRAY DRIFT AT THE APPLICATION SITE IS THE RESPONSIBIUTY OFTHE APPLICATOR. 

The interaction of many equipment-and-wealher-related faclors determine Ihe pOlential for spray drift. The applicator is responsible for 

considering aillhese lactors when making decisions. 

The following drift management requirements must be followed to avoid olf-target movement from aerial applications 10 agricullural lield 

crops. These requirements do not apply to loreslry applicattons. public heallh uses or to applicaHons using dry formulalions. 

t. The dislance of the outer mosl nozzles on Ihe boom must not exceed 3/4 the length of the wingspan or rotor. 

2. Nozzles must always point backward parallel with the air stream and never be pOinted downwards more than 45 degrees. 

Where states have more slringent regulations. they should be observed. 

The applicalor should be familiar with and lake inlo accounllhe inlormation covered in Ihe Aerial Drill Reduclion Advisory below: 

AERIAL DRIFT REDUCTION ADVISORY 

[This section is adVisory in nature and does not supersede the mandatory label requirementsJ. 

INFORMATION ON DROPLET SIZE 

The most effective way to reduce drilt potentIal is to apply large droplets. The best drifl management slrategy is to apply the largest 

droplets thaI provide sufficient coverage and conlrol. Applying larger droplets reduces drill potenlial, bUI will nol prevenl drin if 

~ppllcaHons are made improperly. or under unlavorable environmentat conditions (See Wind, Temperalure and Humidity, and 

"II!'femperature Inversions). 

CONTROLLING DROPLET SIZE 

Volume - Use high flow rate nozzles to apply the highest practical spray volume. Nozzles wilh higher rated flows produce larger 

droplets. 

Pressure - 00 nol exceed Ihe nozzle manufacturer's recommended pressures. For many nozzle types lower pressure produces larger 

droplets. When higher Uow rates are needed, use higher lIow rate nozzles instead of increasing pressure. 

Number 01 nozzles - Use the minimum number of nozztes Ihat provide uniform coverage. 

Nozzle Orientation - Orienting nozzles so that the spray is released parallel 10 the airslream produces larger droplets Ihan other 

orientaUons and ls the recommended practice. Slgni/lcanl deflection lrom horizonlat will reduce droplet size and increase dritt 

potential. 

Nozzle Type - Use a nozzle type that is designed lor Ihe intended application. With most nozzle types, narrower sp~angles produce 

larger droplets. Consider using low-drift nozzles. Solid stream nozzles oriented slraight back produce the larSlillodroplels and Ihe 

lowest drill. •••••• • 

BOOM LENGTH • •• • • • • •••••• 

For some use patterns. reducing Ihe effective boom lenglh to less Ihan 3/4 01 the wingspan or roto:T~~lh may lurlher reduce drift 

without reducing swath widlh. •• •••• : 

••••• •• APPLICATION HEtGHT •• :... • 

Applications should not be made at a heighl grealer Ihan 10 leet above Ihe top 01 the targel plants unless a grealer.neight is required 

lor aircrafl salety. Making applications I'll the lowest height that is sale reduces exposure 01 droplets 10 evaporat~!ant!wind. 

••• • •• .. 

43 
SWATH ADJUSTMENT 

When applications are made with a crosswind, the swath will be displaced downwind. Therefore, on the up and downwind edges 01 the 

field, the applicator should compensate lor this displacement by adjusting the path oltha aircraft upwind. Swath adjustment distance 

should increase, with increasing drill potential (higher wind, smaller drops, etc.). 

WIND 

Crm potential Is lowest between wind speeds 01 2 • 10 mph. However, many factors, including droplet size and equipment type 

determine drill potential al any given speed. Application should be avoided belOw 2 mph due to variable wind direction and high 

inversion potential. NOTE: Local terrain can influence wind pattems. Every applicator should be familiar with local wind patlerns and 

how they allect spray drift 

TEMPERATURE AND HUMIDITY 

When making appllcalions in low relative humidlly, set up equipment to produce larger droplets to compensale lor evaporation. Droplet 

evaporation is most severe when conditions are both hot and dry. 

TEMPERATURE INVERSIONS 

Applications should not occur during a temperature inversion because drift polential is high. Temperalure inversions restrict vertical air 

mixing, which causes small suspended droplets to remain in a concentrated cloud. This cloud can move in unpredictable dlreclions due 

to the light variable winds common during inversions. Temperature inversions are characterized by increasing temperatures with 

altitude and are common on nighls wilh limited cloud cover and light to no wind. They begin to form as the sun sets and often continue 

into the morning. Their presence can be indicated by ground log; however, il fog is not present. inversions can alsO be identified by Ihe 

movement 01 smoke from a ground source or an aircraft smoke generator, Smoke that layers and mOves laterally in a concentrated 

• CIOUd (under low wind conditions) indicates an inversion, while smoke that moves upward and rapidly dissipates indicates good vertical 

air mixing. 

SENSITtVE AREAS 

The pesticide should only be applied when the potential for driltto adjacent sensitive areas (e.g. residential areas, bodies 01 water, 

known habitat lor threatened or endangered species, non·target crops) is minimal (e.g. when wind is blowing away from the sensitive 

areas). 

DIRECTIONS FOR USE 

tt Is a violation of Federal law to use this product In a manner Inconsistent with Its labeling. 

Do not apply this product In a way that wilt contact workers or other persons, either directly or through drift. 

only protected handters may be In the area during application. For any requirements specfflc to your State 

or Tribe, consult the agency responsible for pestlctde regulations. 

Read entire label before using this product. 

Use this product only in accordance with its labeling and with the Worker Protection Siandard, 40 CFR par1170. This standard '''','.al'051 ;~:~~!;:'.~ lor the protection ot agricultural workers on larms, lorests. nurseries, and greenhouses, and handlers of agricultural 

II contains requirements lor training, decontamination, notification, and emergency assistance. It also contains specific 

i and exceptions pertaining to the statements on this label about personal protective equipment (PPE), notification 

workers and restrlcted·entry interval. The requirements in this box only apply to uses ot this product that are covered by the W."ked 

Protection Standard. 

Do not enter or allow worker entry inlo treated areas during the restricted· entry interval (REI) 01 48 hours. The REI is 72 hours in areas 

where average rainfall is less than 25 inches per year. 

PPE lor early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with 

been treated such as plants, soil or water is covaralls over long·sleeved shirt and long panls, chemical resistant 

gloves. chemical resistant lootwear plus socks. and protective eyewear. For overhead exposure, 

also required. 

GENERAL INFORMATION 

•••• A foliar spray 01 PREPfM brand Ethephon Plant Regulator tor Colton will accelerate opening of mature unop~!l"" colton bolls and 

enhance del~li~tion which can result in earlier harvest with an increased recoverable yield. PREP,:.~ri~~ Ethepholltreatment allows 

increased effiCiency lrom a once·over harvest. • •• • • • • 

Some premature drop 01 small, immature bolls may be associated with trealment. Do not apply WQ~ iufficieOit,·ItttIf'ure, unopened 

bolls have daveloped 10 produce Ihe desired yield of colton. • ••• •••• 

A boll is mature when it is too hard to be dented when squeezed between thumb and tingers, too har{i.1J Al6l sliced with*'a.fharp knife, and 

when the seed coat becomes light brown in color. ..:... • • 

For best results, thorough and uniform spray coverage is required. It is essential that the bons are contacted my tlte spray to obtain 

optimum boll opening. Observe treated lields closely. Harvest at optlmun bon opening and defoliation, generallv~1b 21 days alter 

Ireatment. Sustained cold weather with average day and night temperatures of 65"F or lower after treatmollt. .... ith,fREPIM brand 

Ethephon will delay the boll opening response. • .: 

44 
DO NOT APPLY PREpN BRAND ETHEPHON IF RAIN IS EXPECTED WITHtN 6 HOURS. Rainlall within 6 hours of application may 

reduce product performance. 

CertIfied cotton seed growers should observe bon and seed maturity belore treatment with PREpT" brand Ethephon. Bolls not 

completely mature might open with trealmenl 01 PREPTM giving lower quality seed. 

tMPORTANT: Do not apply PREpr ... brand Ethephon through any type of irrigation syslem. 

SPRAY PREPARATION 

Add 1/2 fo 3/4 of the requIred amount of water to the spray lank. Start agitation. Add the required amount 01 PREP'''' brand Efhephon, 

and the remaining amount of water. Prepare only as much spray solulion as can be used on the day of mixing. Do not anow spray 

solution to stand ovemlght. 

Do not spill Ihe concentrated product on spray equipment, or any airplane parts. ANY SPILLS SHOULD BE RINSED IMMEDIATELY 

WITH PLENTYOFWATEA. 

Use 01 a nurse tank is highly recommended lor avoiding possible spills of concentrated lormulation on spray equipmenl or any airplane 

parts. 

eQUIPMENT CLEANING 

Spray deposits of PREP'" brand Ethephon , when lett on aircraft acrylic plastic type windshields lor longer than t hour, may react with 

this material, forming an opaque tilm or spots on the surface which cannot be removed by washing wilh water or any other cleaner. 

Rinse windshietds with water immedialely after each tank load of PREpw has been applied. Thoroughly rinse the aircraH with clean 

water aller each day PREPThI is applied . 

• PREprM brand Ethephon may also affect certain paints, and if accidental deposits on painted objeclS such as cars, trucks, agricultural 

equipment. efc. occurs, these obiects should be rinsed with water as soon as possible (within 1 hour) to prevent permanent staIning 01 

the painted surface. 

Because otthe acidic nature 01 this producl, prolonged exposure to spray deposit will damage acrylic plastics. certain paints, and 

metals. 

Rinse Ihoroughly with a detergent and water all exposed acrylic plastic-type materials (e.g., aircrart windshields), and painted surfaces 

within an hour after exposure to spray deposits. AI the end 0/ each day, rinse thoroughly with a delergent and water all the metal parts 

01 the aircraft and the associaled spray equIpment exposed to the spray deposits. 

BOLL OPENING 

CONDITIONS EXPECTED 

5·7DAY$AFTER 

TREATMENT 

Hot and dry 80'F or higher 

•

Dry wilh temperature 

75'F10 SO'F 

Cool but higherthan 65'F 

Rank collon 

Rates 

PAEpN 

QUARTS/ACRE 

1.0 (1.0 Ib a.i.) 

1.5 (1.5 Ib a.i.) 

2.0 (2.0 Ib a.1.) 

2.0 (2.0 Ib a.1.) 

FQ[ Boll Opening 

ONE GALLON $PRAYVOLUME 

OFPREpTM !3ALJAQBe: 

TREATS GROUND AIR 

4 Acres t5to 50 2to 5' 

2.5 Acres t5to 50 2 to 5' 

2 Acres t5t050 2 to 5' 

2 Acres 25to 50 5 

'NOTE: For California and Arizona use a volume of no less than 5 ganons per acre lor aerial applications 

Tiroe of Application (Boil Opening) 

Apply when there are sufficient mature unopened bolls to produce the desired yield, but no later than when 60% 01 the bolls are opened 

(see General Information section on how to test for boll malurity). Do not tank mix PREpT" brand Ethephon with a desiccant il the 

collon is to be spindle harvested. 

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45 
PRECONDITIONING FOR DEFOLIATION 

Rates For preconditioning For Defoliation 

CONDITIONS EXPECTED ONEGAUON SPRAY VOLUME 

5·7 DAYS AFTER PREPfM OFPREPn.· GAL.lACRE 

TREATMENT QUARTS/ACRE TREATS GROUND AIR 

Hot and dry BO'F or higher 0.5 (O.S Ib a.i.) B Acres 15 to 50 2t05' 

Cool but higher than 6S'and 1.0 (1.0 Ib a.i.) 4 Acres 15 to 50 2 toS" 

also for rank cotton 

'NOTE: For Califomia and Arizona use a volume of no less than 5 gallons per acre for aerial appHcations. 

Time of Application (Preconditioning) 

Apply PREprn brand Ethephon 4 to 7 days prior to application of defoliant or tank mixed with the defoliant (see section on 

Compatibility), Do not tank mix PREP"" with desiccants unless plant desiccation is required. 

Pre-treatment With Defoliants prior to PBeprn Treatment 

• f the cotton Is overly rank or laying down in [he middles and good spray coverage of the bolls with PREprM brand Ethephon is diflicu[[, a 

pretreatment with defoliants will be useful to improve boll coverage with PREpT1>I. Use dosage rates of PREp¥M recommended for boll 

opening. Read and observe atl appropriate [abel use directions and precautions for the defoliant used. 

Do not use a defoliant before there are su[fiCient mature unopened bolls to produce the desired y[eld (see Genera[ Information section 

on how th test for Bo[[ Maturity). 

COMPATIBILITY 

PREE=' brand Ethephon is compatible with DEF, FOLEX, DROPP, HARVADE, METHYL PARATHION, GUTHION AND MALATHION, and 

may be applied in sequence or as a tank mixture (DO NOT TANK MIX WITH DEFOLIANTS OR DESICCANTS IN CALIFORN[A AND 

AR[ZONA). [n some cases slight reduction in boll opening response has been observed when tank mixes wifh defoliants were used. 

Good agitation in the spray tank is essential and a tank mixture should not be allowed to stand without agitation for more than 5 to to 

minutes. Read and observe all appropriate Iabe[ use directions and precautions for the defoliants and insecticides used. 

PRECAUTfON: 

NOTE: UNDER CERTA[N CONDITIONS, TANK M[XTURES OF PREP"'" BRAND ETHEPHON WITH DESICCANTS CONTAIN[NG 

SODII,lM CHLORATE COULD RESULT [N THE FORMATION OF HYPOCHLOROUS ACIDS WHICH ON HEATING WILL EMIT TOX[C 

CHLORIDE FUMES. 

DO NOT MIX PREprn BRAND ETHEPHON W[TH AMMONIUM THIOSULFATE, SUCH TANK MIXTURES MAY RESULT [N FORMAT[ON 

_OF TOX[C FUMES. 

WHEN TO HARVEST: 

Do not harvest cotton sooner than 7 days after a treatment with PREpI'M brand Ethephon. Observe the treated crop and harvest when 

optimum bon opening has been reached. Too early harvest might reduce the full advantage of the treatment and too late a harvesf may 

result in reduced quality and loss of lint which will drop from the plan!. 

USE LIMITATIONS 

• Do not exceed a maximum of 2.0 lb. ethephon active ingredient per acre per year through combined or repealed uses of any 

ethephon products. 

• Boll Opening: Do not tank mix PREP'" brand Ethephon with a desiccant if the cotton is to be spindte harvested. 

• Pre-Condition for Defo[iation: Do not tank mix pREP'" brand Ethephon with desiccants unless plant desiccation is required. Do not 

use a defoliant before thero is sufficient mature unopened bolls to produce the desired yield {see Genera[ Information section on 

how to tes! for bon maturity. 

• Do not plant another crop within 30 days after trea[men\. 

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USE PRECAUTIONS 

Avoid spray drift to nearby crops as this product will cause modifications in plant growth. Plant injury or reduced yields wilt result 

Mix only the amount of spray you expect to use each day. Do nol allow mixed solution to stand overnight. 

STORAGE AND DISPOSAL 

STORAGE 

Do nol contaminate waler, food, or feed by storage or disposaL 

PESTICIDE DISPOSAL 

Pesticide wastes are acutely hazardous, Improper disposal of excess pesticide, spray mixture, or rinsata is a violation of federal law. 

If Ihese wasles cannot be disposed of by use according to label instructions, contact your Slate Pesticide or Environmental Control 

Agency or the Hazardous Waste representative altha nearest EPA Regional Office for guidance. 

CONTAINER DISPOSAL 

Triple rinse (or equivalent) the empty containers. Then oUer for recycling or reconditioning, or puncture and dispose of In a sanitary 

landfill, or by incineration or it allowed by state and local authorities, bv burning, II container is burned, stav out of smoke. 

LIMITED WARRANTY AND DISCLAIMER 

_rhe manufacturer warrants (a) that this product conforms to Ihe chemical description on the label; (b) !hat this product is reasonably fit 

tor the purposes set forth in the directions for use when it is used in accordance with such directions; and (c) that the directions, 

warning and other statements on this label are based upon responsible experts' evaluation of reasonable tests of effectiveness, of 

loxicity to laboratory animals and to plants, and ot residues on food crops and upon reports ot field experience, Tests have not been 

made on all varieties or in all states or under at! condilions. THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES. EXPRESS OR IMPLIED, AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS. WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABiliTY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR OTHERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTION, 

TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE PRICE FOR, THE QUANTITY OF PRODUCT WITH RESPECT TO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL. INDIRECT OR 

_CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. 

Rh6ne·Poulenc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, North Carolina 27709 

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PREP is a trademark of RHONE·POULENC, ••••• 

PREplM brand Ethephon Plant Regulator for Colton (PENDING) Submitted 1116196, Resubmitted 4/1Jat •• 

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RHONE·POULENC AG COMPANY 

EPA Correspondence No. GSP/eth/044 

April 17, 1997 

U.S. Environmental Protection Agency 

Office of Pesticide Progmnls 

Document Processing Desk (H7504C) 

Room 266A, Crystal Mall 2 

1921 Jefferson Davis Highway 

Arlington, V A 22202 

Attn: Ms. Cynthia Giles Parker (PM No. 22), 

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RE: EPA Reg.iND. 264~380 PREp"fM brand Ethcphon Plant Regulator For Cotton; Label 

revisions in response to your correspondence of March 27, 1997. 

Dear Ms. Giles - Parker. 

I am SUblllilting five copies of a draft label with the corrections which you requested in 

your March 27, 1997 correspondence. 1 have highlighted the changes on one of these 

labels to facilitate your review. 

The following changes huve becilinilde: 

Hazards to Humans Section: 

Replaced text with recommended wording . 

Statement of Practical Treatment Section: 

Chm1ged title to "FIRST AID" 

Deleted "If Illimled" Statement 

If ou Skin: added: "Get medical auention." 

If Swallowed: added "Call" physician or Poison Control Center". 

If in Eyes: Chauged Get Medical ... 0phthalmologisI" 10 lower Cilse. 

Note to Physician Section: 

Added: "Treat symptomatically. Consideration should be given to the possibility 

thut over exposure to materials other than this product may have occurred. No 

specific antidote is available. Probable mucosal damage lllay contraiudicate the use 

of gastric iavtlge." Tllis statcmCllt complies with your input and was rccOinmended 

by oilr corpOr<1te physician as appropri.ne for all ethephon labels. 

Deleted: Entire prior statement. 

Deleted Note to Physician section froll1 the Hazards to Humans Section 

PO BOX 120 [4.;> TW ALn<Al·1Q[fl OlliV[ 

RESEARCH TRIMjGLE PARK, N C ;>77C0·20 [~ 

(919)549·2000 

Excellence In Performance 

Pride in Achievement 

[NTERUATIOUAlIELrX NUMl!€1l ~9'YJ37nNjSl'lnlRACK APe f1TP 

INTEANATIONAL DISTRIBUTION SHIVICES ffl.EX NUMBER 4!?J'J37;·M~SWErl8!<CK APC IDS 

48 ----------
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PPE Section: Modified glove statement to meet current requirements. 

Environmental Hazards Section: 

Deleted: "For terresuial uses". 

Ingredients: Lined up decimal poinl~. •••••• • •• • • 

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• • ....... •••••• • Directions for Use section: • ••• ~... 

Removed first par:tgraph from Agricultural Use Requirements bO~lQ.t£xt above·.: 

box. ..:... • 

Use Limitations section: Modifed 2.0 lb ai/A statement as suggested. 

If you have any questions concerning this matter, J can be reached at 919~549-2687 . 

~~ Gail Powell, Ph.D. 

Registration Manager 

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CERTIFIED MAIL 

Gail Powell Ph.D . 

Rhone-Poulenc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, NC 27709 

Dear Dr. Powell: 

Subject: Reregistration 

/I~H 27 1997 

PREP brand Ethephon Plant Regulator For Cotton 

EPA Registration No. 264-380 

Your Submissions Dated January 16 and March 13,1996 

We cannot accept your labeling submitted for reregistration of ethephon until you 

submit five (5) draft labels with the following corrections: 

1. Update the Hazards to Humans section so it reads as follows: 

Corrosive. Causes irreversible eye damage and skin irritation. Harmful if 

swallowed or absorbed through skin. Do not get in eyes on skin or on 

clothing. 

2. In the Statement of Practical Treatment Section you may delete the IF INHALED: 

section since this product is in Toxicity Category IV for inhalation toxicity. At the bottom 

of this section modify the NOTE TO PHYSICIAN to read: 

Probable mucosal damage may contraindicate the use of gastric lavage. 

3. In the IF ON SKIN section add: 

Get medical attention. 

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4. Modify the If Swallowed section to include: 

Call a physician or Poison Control Center 

5. Delete the Note to Physician section in the Hazards to Humans section. 

6. In the Environmental Hazards Section delete "For terrestrial uses,". Refer to 

PR Notice 93-8. 

7. In the ingredient declaration assure when the label ',s printed that the decimal 

points are aligned on the same margin. 

8. Move "Do not apply this product in a way .... agency responsible for pesticide 

regulations" out of the Agricultural Use Requirements section to immediately below the 

heading "It is a violation of Federal. ... with its labeling." 

9. Modify the Use limitation so it is clear that the maximum that can be applied to 

cotton is 2.0 lb. of ethephon as active ingredient per acre from all sources of ethephon not 

just this product. 

Submit the labeling refiecting the above mention changes to the Agency for review 

within fifteen (15) days of receipt of this letter. Failure to do so will result in issuance of 

a Notice of Intent to Suspend your product's registration. 

cc: Wanda Daughtry 

Judy Loranger 

Reregistration Branch 

Sincerely, 

Cynthia Giles-Parker 

Product Manager (22) 

Fungicide-Herbicide Branch 

Registration Division (7505C) 

Special Review and Reregistration Division (7508W) 

53 
PRE PTM brand Ethephon 

PLANT REGULATOR FOR COTTON 

FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. 

NOT FOR RESIDENTIAL USE. r 

ACTIVE INGREDIENT: J 

E,hephon (2~chloro9thyl) phosphonic acid- ....................................... , ................................. ,., ...•........... 39.9% 

INERT INGREDIENTS: ......................................................................................................................... 60.1~ 

-This product contains 4 pounds ethephon per gallon. 

EPA Reg. No. 264·380 EPA Est. No. 264·PA·Ol~ 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

Si ustGd no entiende Ia etiqueta, busqU8 a algulon para. quo so la explique a usted en dGtalle. 

(If you do not understand tho 1abcK, find someone to explain it to you in detaH.) 

~FoOirr:MM]EiiD]jIC:;;AruLDAr.;nidd-:I~B~A~Ntrn;S~P~O~B~I~A~T~IO~N:E~mm.e.r~gj;i.iincCiI~ •• SioijN~Li:Y~C5i.~IIC22:4~H~o~u~r.~A;'oDa;.Y~I:j.Biioo-i(j:i3i3344-'i7S57~7r For PRODUCT.u.s.e. Information Call 1 .. 800 .. 334 .. 9745 

The use 01 this product for a variety of plant growth regulation usa. is covered by United States and 'oreign patents including 

U.S. Patont 4,240,8t9. No licans. is granted to use this product in countries other than the United Slates or lor any use not 

contemplated by this labol. LIability for palont infringamant may rasult from usa or sale of this prodoo outside the United States. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyelids opon and flush with a stoady. gentle stream of wator for at least 15 minutes, GET MEDICAl ATIENTION. 

PREFERABLY AN OPHTHAlMOlOGIST, 

IF ON SKIN: Immediately ~h with plenty of soap and water. 

IF SWALLOWED: 00 not indoco vomiting. Promptly drink a large quantity of milk. egg whites, gelatin solution or if these aro not 

available. drink large quantitioe of water. Avoid alcohol. catI a physician immediately. 

IF INHALED: Remove victim to fresh air. If not breathing; give artificial respiration. Administer oxygen if nGCOssary. GET MEDICAL 

ATTENTION. 

NOTE TO PHYSICIAN 

~ specilic antidote is available. All troatmants should be basad on obSIiUVed signs and symptoms of distre .. In the pationt. 

C \ erexposur~.to materials other than this product may have occurred. 

lalms of severe overexposure. by Inhalation, should be kept under medical observation for up to 72 houra for delayed on"t of 

, 'l pulmonary adema. In a victim of overexposure by Ingestion. careful gastric lavage is required duo to tho possibility of stomach or 

esophageal perforation. This material Is an acld, but the usa of alkaUno sub&tancaa to nautrali.ul it is contraindicated. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

Corrosive. Causes eye damage and skin Irritation, 00 oot got in eyes, on skin, or on dothlng. 

Harmlul or fatal if swalloWed. Avoid oontamination of food. 

NOTE TO PHYSICIAN ••••• • 

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No spocific antidole is availablo. All treatments sllouid be based on obselVed signs and symilT&rfll:of dlsfr.s5·ln the patient, 

Ovorexposure to materials other than this product may have occurred. •• •• • : 

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VICtims of sever. overexposure, by inhalation. should be kept undOf medical observation for up "0!Aa. Ftours for delayed onset of 

pulmonary odema. In a victim of ovorexpo&ure by ingestion. careful gastric lavage is required duo to the, ~bili¥of stomach Of 

esophogoaJ perforation. This material is an acid, but the usa of aJkaline substances 10 neutralize it is oontntindicatGu;·· • 

54 
PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and other handlers must wear long-sleeved shirt and long panw, waterproof gloves, Sho08 plus socks and protectivG 

ayawamr. 

Whon handlers use closod systoms, enclosed cabs, or aircraft In a mannor that moots tho requirements listod in tho Workor Protection 

Standard (WPS) lor agricukural pestlcidos (40 CFR 170.240 (d) (4-6)], the handler PPE requiremants may be reduced or modified as 

spociliod in tho WPS. 

Discard clothing and otho, absorbent material. that have boon drenchod or heavfly contaminatod with thla product's concontrato. Do 

not rouse them. Follow manulact.uror'. instructions lor cleaning/maintaining PPE. "no such Instructions lor washable8. use dotergent 

and hot walor. Koep and wash PPE separatoly from othor laundry. 

User ::safety Recommendations 

Us .... should wash hands boforo eating, drinking, chowing gum, ualng tobacco or using tho tc»lot. 

Users should romovo clothing immodlatoty if pGstlcldG gots inside. Than wash thoroughly and put on claan clothing. 

UUr& should removo PPE immodiately att.r handling this product. As soon as possiblo, wash thoroughly and chango Into cIoan 

clothina. Wash the outside of olovas belon~ removina. 

ENVIRONMENTAL HAZARD 

Avoid s drift to nearby ct'0p8 as this product may cause temporary modification. in plant growth. 00 not contaminate walor used ai9f"- allon or mastic purposes. 

'f8Itor terrestrial use ,do not apply directly to water. or 10 areas wher. surface water Is present or to intertidal areas below tho maan/~h I water mark. t contaminate water when disposing of oqulpmont waahwat8fS. 

bo.""'''''coc.ed the rate of PREptw brand Bhophon Plant RogulatOf' for Cotton per aero per y .... recommendod on this Iabot. 

SPRAY DRIFT 

Avoid spray drift. Do not apply whGn weather conditions may cause drift_ Do not allow this product to drift on to non-target are ... Drift 

may result in Plogal ratidue, or injury to adJacent crops and vegetation, In tho form of Ie at yalJowlng and detollatlon. To avoid $pfay 

drift, DO NOT apply aerially when wind spood Is greater than to mph or during periods of temperaturo inversions. Uao of Jargar droplet 

size wiN also radooa apt'ay drift. 

AVOIDINGSPRAV DRIFT AT THE APPUCATJON SITE JS TIiE RESPONSIBtuTYOF TIiE APPLICATOR 

Tho interaction of many equipment-and-weather-related factors dotermine the potential for spray drift. The applicator I, reaponeibkl for 

considering aU the'e factotS whon making decisions. 

The fallowing drift management requirements must be foUowod 10 avoid off-target movement from aerial applications 10 agricuitural field 

crops. Those requirements- do not apply to forestry appIk:atiomJ. public hoahh UMS or to appIlcat/ona U1Jiog dry fonnulatlons. 

1. The distance of the oUier moat nozzlN on tho boom must not exceed 314 the kangth of the wingspan or rotor. 

2. Nozzles must always point backward parallaf with the air stream and never be pointed downwards more than 45 dogr .... 

• oore statas have mora Slringent regulations, thoy should be absOlVed. 

The applicator should be familiar with and take Into account tho Information covered fn the Aerial Drift Reduction Advisory below: 

~~IDAL~~R1FT REDUCTIO~ ... ADYlSO~L_.~_ ~ 

t[ThIS section is advisory in nature and does not supersede the mandatory label roquitomGirt!D 

mF'ORMA'RON ON DROPtET SIZE -

The most effective way to reduce drift potontlalls to apply large droplets. The beat drift management strategy 18 to apply the largest 

droplets that provide sufficient coverage and control. Applying targer droplots reduce. drift potentla~ but will not prevent drift if 

applications are made improperly, or under unfavorable onvironmental conditions (See Wind, Temperatur. and Humidity, and 

Temperatur. Inversions). • ••• 

• • CONTROLUNG DROPLET StZE •••• 

Volume - Use high llow rate nozzles to apply the hlghost practical $pfay volume. Nozzles with higher rated;~prodoco largor 

droplets. • ••••• • 

Pressure - Do not oxceod the nozzle manufacturers racommended pressures. For many nozzle tyPos 4wler prou.uto.produces larger 

droploa. When highOf' flow rat08 are needed, use higher flow rate nozzles instead of increasing prelW.llt.. : •••• 

Number of nozz.lea ~ Use the minimum number of nozzles that provide uniform coverage. • •• • •• 

• •• Nozzle Orientation - Orienting nozzles 80 that the spray is released parallel to tho airstroam ~. larger·d'ro~ than other 

orientations and is the recommended practice. Signilicant dellection from horizontal wPI reduM ·4rbp/et siz~ $d Increase drift 

potential. : •••• 

Nozzle Type ~ Use a nozzlo type that Is designed for tho intended application. WIth moat nozzfe typGt, narrowor aP(.y-anglN produco 

larger droplets. Consider using Iow-drift nozzles. Solid stroam nozzles oriantod straight bad< prodoco the latJi"cllQPkml and the 

lowest drift. • ,. • 

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BOOM LENGTH 

For some UM patterns, reducing the offective boom length to loss than 3/-4 of tho wlngspatl or rotor length may lurther reduce drift 

without rGduclng swath width. 

APPLICATION HEIGHT 

Applications should not be made at a height grealer than to feet abow the top of the target planta unleso a grealer height Is roquirod 

for aircraft safety. Maklng applications at the lowest height that is safe r&ducas exposure of dlOplet81o evaporation and wind. 

SWATH ADJUSTMENT 

When applications are made with a crosswind, the swath will be displaced downwind. ThGl'oforo, on the up and downwind edges of the 

field, the applicator should compensate for this displacoment by adjusting tha path of tho aircraft upwind. Swath adjustment distance 

should increase. with increasing drift potential (higher wind, smaller drops, etc.), 

WIND 

Drift polential Is lowest batween wind speeds of 2 - 10 mph. Howover, many factors, including droplet size and 8(Julpment type 

determine drift potential al any given speed. Application should be avoided below 2 mph duo to variable wind direction and high 

invarslon potential NOTE: Local terrain can influence wind patterns. Every applicator should be familiar with local wlnd patterns and 

how they affect spray drift. 

TEMPERATURE AND HUMIDITY 

When making appIlcatioll6 in low relative humidity. sot up equipment to produce larger droplets 10 compensate for ovaporation. Droplet 

evaporation Is most80vere when conditions 81e both hot and dry . 

.lEMPERATURE INVERSIONS 

~icatlons should not occur during a temperature invorslon because drift potential is high. Temperature Inversions restrict vortk:al air 

mixing. which caUSA sman suspended droplata 10 remain In a concentrated cloud. This cloud can move in unpredictable dilections due ' 

to the light variable winds common during inversions. Temperatura inversions ara charaderilod by Increasing temperaturas with /. 

akituc.le and are common on nighta with IImitoo cloud oover and light to no wind. They begin to form as the sun seta and otten continue 

into tho morning. Their presence can bG indicated by ground fog; howover. if fog is not present, inversions can also be identifiod by tho 

movoment of smoke from a ground source or an aircraft smoke genorator. Smoka that layers and movo. lateralt{ in a ooncontratod 

cloud (under bw wind oonditlona) indicates an inversion, whU. amok. that mov .. upward and rapidly disaipatG8 indlcatoa good wrtlcal 

air mixing. 

SENSITIVE AREAS 

The pesticide sllould only b. applied whon the potontlal for drift 10 adiacont sensitiva araas (a.g. residential areu, bodlos of water. 

known habitat for thr.a!al'\Od or andangered apocioe:, non-targot crops) ia minimal (e.g. whan wind Is blowing away from tha sonsitiva 

areas). 

DIRECTIONS FOR USE 

~--;:=:::::=~:Ia~~'_V~Io=I.~t~lo~n~O~'_F~'~d~.~r:al law to u .. thla product In a manner Inconslstant with Ita lahellng. /' Read onth tabol boforo usIng th,* product 

not apply this product In a way that wm oontact workers or other persons, either direcUy or through drift. Only prot"actod:~n:.r:.:~~:1 be in the area during application. For any requirements specific to your State or Tribe. consult the agency n 

!!illi!r~&g1~Uljm~~!ns~.~~~~~li!~~1j~l!i~~ with itsi&beling and with the Worker Protection Standard, 40 CFR part 170. Thia standard 

I workers on fatms, fetests, nursari .. , and greenhouses. and handlers of 

decontamination, notification, and emergency assistance. It 

on this label about personal prot&CtivG equipment (PPE), 

In this box only apply to uses of this product that ara covered by the 

00 not entor at aJbw worker entry into treatOO areas during the rostrided-ontry interval (REI) of 48 hours. The REI is 72 hours in 

average rainfall is 1e88 than 25 Inchaa par yeat. • •• _. _ 

required for eatly ontry to treated areas thatla pormittad under the Womer Protection Standard and that In~lt .. contact 

1~;;YiI;II,;;g that has boen treated such a8 plants. SOH or water is covaralls over Iong·sleeved shirt and long pantt..~'Wtca'll :~~~:::~I as any waterproof gloves. chemical resistant lootwear plus socks. and protective eyewaar. For t)vorh.ad a 

headgear is also required. _ 

GENERAL INFORMATION • • • •• 

A tonal spray of PREPTM brand Ethophon Plant Regulator for Conon w~1 8CCGlorate opening of m·al~ro· wnopanoa cOlton boBs and 

enhance defoliation which can result In earlier harvest with an increased recovorable yield. PREPTM~lM Ethephon tremmant alows 

Increasod efficiancy from a once-over harvost. : __ •• 

Some prematuro drop of small. immature bolls may be aasodated with treatment. 00 not apply bolor. sufficient.-maTure. unoponod 

boHs have developod to produce tho desired yield of ooHon. _ - -: - _ ... 

56 
A boll is mature when it is too hard to be den10d whon squoezed bGtwoon thumb and fingGf'S, too hard to be sliced w~h a sharp knife, and 

whoo tho sood coat bocom08 light brown in color. 

For best results, thorough and uniform spray covorago is required. It is ossontial that tho boUs are oontadod by the spray to obtain 

optimum boH opening. ObsolVe troated fields cIosoly. Harvost at optlmun bon opening and dofoliation, gonaralty 14 to 21 days aftar 

!rammont. Suslainod oold woather with average day and night tomperaturas of 65°F or Iowar aftor troatmant with PREptN brand 

Elhophon will dalay the boll opening rosponse. 

DO NOT APPLY PREp'IV BRAND ETHEPHON IF RAIN IS EXPEClEO WITHIN 6 HOURS. Rainfall within 6 hours of application may 

reduce product performance. 

Cartified coHan seed grower. should ob$afVo boll and sood maturity bofor. treatment with PAEPlW brand Ethaphon. Bolls not 

oompiGtoly mature might opon with tr88tment of PREpn!: giving Iowar quality nod. 

IMPORTANT: Do not apply PREPT" bfand Ethophon through any type of Ifriga1lon system. 

SPRAY PREPARATION 

AI:Jd 112 to 314 of the required 8Jl'IOUnt of watGf to the spray tank. Start agitation. Add the required amount of PRE!»" brand Ethephon, 

and tho remaining amount of water. Prepare only as much spray solution as can be usoo on the day 01 mixing. Do not ailow spray 

solution to stand o .... rnlght. 

Do not spill the (XIncentrated product on spray equipm.nt, or any airplane parts. MY SPillS SHOULD BE RINSED IMMEDIATELY 

WITH PLENTYOFWATER. 

Us. of a nurse tank is highly recommended for avoiding possible spills of oonoantrmoo formulation on spray equipment Of any airplane 

parts. 

eQUIPMENT CLEANING 

Spray daposits 01 PREPN brand Bh&phon , when loft on aircraft acrylic plastic type windshields for longer than 1 hour, may react wflh 

this materlaJ, forming an opaque film or spots on the surfacG which cannot be remo ... ed by washing with water or any other cleaner. / 

Rinse windshleld:$ wflh watGf Immedlatoly aft.r .ach tankload 01 PREPnI has hoen applied. Thoroughly rinse the aircraft with clean / 

watGl' after each day PREptw Is appIiod. 

PREPN brand EthGPhon may also aifGCt certain paints. and if accidental deposits on palnted objects such as cam, trucks, agricultural 

equipment, etc. OCCtJrs, the .. ob}octs should be rinsed with water as soon as poosiblo (within 1 hour) to prevent permanont staining of 

the painted surface. 

BecaU88 of tho acidic natura of this product, prolonged .xposur. to spray deposit will damage acrylic plastic:8, certain paints. and 

metals. 

Rinse thoroughly wflh a detergent and wat.r all oxposed acrylic plastic-typo mawrials (e.g., aircraft windshlolds), and palntocl surfaces 

withio ao bour after exposure to spray deposits. At the end of 9ach day. rinao thoroughly with a d.tergent and wat.r all tho matal parts 

of tho aircraft and tho aaGOclatod spray equipment .xposed to tho spray dapoW. 

BOLL OPENING 

~D!T1ONS EXPECTED __ 7 DAYS AFTER 

TREATMENT 

Hot and dry BO'F Of' higher 

01)' with tomperature 

75'FtoSO'F 

Bates For Boll Ooenlnp. 

PREi"" 

QUARTS/ACRE 

t.O (1.0 b a.i.) 

1.5 (1.5 Ib .. 1.1 

CNEGAllCN 

OF PRE'" 

TREAlS 

4 Act .. 

2.5 Acrea 

SPRAY VOLUME 

GALlACAE 

GRQUND AIR 

t5 to 50 

15 to 50 

2t05-

2 to 5-

CootbuthigharthanSS"F 2.0 (2.0 Ib&.i.) 2 Act.. 151050 2t05· 

Rank cotton 2.0 (2.0 b a.1.) 2 Acres 25 to 50 5 

*NOTE: For Califomia and Arizona usa a voIum. of no i06$ than 5 gallons per acr. for 8Gfial applications •••• • • 

•••• 

Time of Application (Boll Opening) • • •••••• • 

Apply when thor. are sufficient mature unopaned bolls to produce the dGsiTod ylold. but no iat.r than~eO% of thoPOIIG: are opened 

(s8e Gan.ral Information S&CIion on how to t.st for bolt maturity). Do not tank mix PREPm branc( EttfoJ#lon wltO a g.slccant if tho 

ool1on is to be spindle harv.sted. •• • •••••• • •• • • •• .. -.. • • ••••• 

• • 

• •• 

• ••• 

• 

• •• •• • •••• 

•••• 

• •• •• • 

57 
PRECONDITIONING FOR PEFOllATIClli 

Bates Eor Preconditioning For Defollatloo 

CONDnlONSEXPECTED 

5-7 DAYS AFTER 

TREATMENT 

ONE GAlLON SPRAY VOLUME 

Hot and dry aO'F or higher 

Cool but higher than 55'and 

also for rank cotton 

PA€P"' 

OUARTS/AcRE 

0.5 (0,5 Ib a.i.) 

1.0 (1.0 Ib a.L) 

OFPREI'"' GAl rACAE 

mEATS GROUND 

8kres 15 to 50 

" Acres 15 to 50 

'NOTE: For Califomia and Arizona usa a volume of no 1&81 than 5 gallons per acra for aerial applications. 

Time of Application (Preconditioning) 

AIR 

2105" 

2105-

Apply PREPrw brand Ethephon 4 to 7 days prior to application of defoliant or tank mixed with tho dGfofiant (sao section on 

Compatibility). Do not tank mix PREp1'M w~h desiccants unless plant desiccaJion is required. 

pre-treatment With pefollants Prior to PREpN Treatment 

• 

the cotton is overly rank or laying down in the middles and good spray coverage of tho beUs with PAEPD' brand Ethephon is difficult. a 

retraatment with defoliants wi» be useful to improve be" coveraga with PREP'"", Use dosage ratos of PREPN recommended tor boll 

opening. Read and observe aU appropriate label use dirGCtions and precautions for tho dQfoliant used. 

Do not use a defoliant boIora there atO sufficient maturo unopened bolls to produce tho desired yield (see GGnarallnformatlon section 

on how th tast for Boll Maturity). 

COMPATIBILITY 

PREP'" brand Elhephon 1s00l11plllble wah DEE. FOLEX. DROPP. HARVADE. METHYL PARATHION. GUTHION AND MALATHION. and 

may be appIiGd In sfKluonco or as a tank mixture {DO NOT TANK MIX WITH DEFOlIANTS OR DESICCANTS IN CAliFORNIA AND 

ARIZONA}. In some casas slight reduction In boO opening rosponse has bHn cbsarvod when tank mixes with dafollanta were U&Gd. 

Good agitation in the spray tank Is oaaential and a tank mixtuf4t should not be allowed to stand without agitation for more than 5 to 10 

minute •• Read and obsaMI all appropriate labol use diroctions and precautions for tho defoUanta and insocticidee used. 

PRECAUTION, 

NOre, UNDER CERTAIN CONDITIONS. TANK MIXTURES OF PREpN BRAND ETHEPHON WITH DESICCANTS CONTAINING 

SODIUM CHLORATE COULD RESULT IN THE FORMATION OF HYPOCHLOROUS ACIDS WHICH ON HEATING WILL EMIT TOXIC 

CHlORIDE FUMES. 

00 NOT MIXPREI'"' BRAND ETHEPHON WITH AMMONIUM THIOSULFATE. SUCH TANK MIXTURES MAY RESULT IN FORMATION 

OF roXIC FUMES. 

_HEN TO HARVEST, 

Do not harvast cotton soon.r than 7 days atter a treatment with PREfm' brand Ethephon. Obsorvo tho Ireatoo crop and hllVest when 

optimum boD opening has bGon raachOO. Too .arty harvest might rGduce tho fuN advantago of the treatment and too lat. a haIvo.t may 

r.suk in rGducod quality anc:Ilosa of Unt which wiU drop from tho tant 

USE LIMITATIONS • 

, ~~~~~ '. 

Do not exceed a maximum of 2.0 lb. aiJA for combinod uses o~e~1'M mnd Ethophon par'fa"e per year. 

Boll Opening: Do not tari< mix PREP'"' brand Ethephon with a desiCCarnif-th~.to--!)8 spindle harvosted. 

Prft.Condillon for Defoliation: Do not tank mix PREPN beand Ethaphon with desiccants unless plant dosiccationA Wluifad. Do not 

usa a dafollant before th.r. is sufficient maturo unoponod bolla to produce the dosirGd yield (sae General Infqrpwlbn section on 

how to test for boH maturity. 

Do not plant anothar crop within 30 days after treatment 

• ••••• 

• •• 

• • •••••• • 

• • ••• 

• ••••• • • 

•• 

••••• 

• • ••••• 

•• • • •• 

• • • •• 

• ••• 

• 

• •• •• • 

•••• 

•••• 

• •• •• • 

58 
..... --.----.-.--.-.. --.-------------~ 

USE PRECAUTIONS 

Avoid Ipfay drift 10 nearby crops as this product wiU cause mod~icalion8 in plant growth. Plant injury or reduced yields will resU«. 

Mix only the amount of spray you oxpect to USG each day. Do not aUow mixed solution to stand overnight. 

STORAGI: AND DISPOSAL 

STORAGE 

Do not contaminato water, food, or food t7t swrage or dispos.aJ, 

PESTICIDE DISPOSAL 

Pesticide was10a 818 acutely hazardous. ImPl'opor disposal of excess pesticide, spray mbcturo, or rlnaate is a violation of foderallaw. 

If thoso wastes cannot be disposed of by use according to labollnstruction., contact your State Pestlclde or Environmental Control 

Agoney or tho Hazardous Wast. reprosentative at the noarest EPA Regional Office for guidallCG. 

CONTAINER DISPOSAL 

Triple rinse (or equivalent) tho empty containers. Thon offer for recycling or reconditioning, or puncture and dispose of In a sanitary 

landfill or iW-lncinoration or if allowed bv stato and local authorities bv bumino. If containor is burned, slav out of smoke. 

LIMITED WARRANTY AND DISCLAIMER 

•• manufacturer W81ranta (8) that this product conform. to tho chemical description on the label; (b) that this product is r.asonably fll: 

for the purpose •• et forth In the ditoctlons for use when it Is used In accordanoo with such directions; and (c) thal tho directions, 

warning and other statements on this labol ara ba&od upon responsible exports' evaluation of reasonable tests: of effectiveness, of 

toxicity to laboratory animals and to plant., and of residue. on food crops and upon r~ports of flold experience. Teats have not been 

made on all varietloa or in aU state. or under all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT _ 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND ITI 

EXPRESSLY EXCLUDES AND DISCLAIMS AlL IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR 

PURPOSE. ,-I 

THIS WARRANTY DOES NOT EXTEND TO. AND THE BUYER SHAlL BE SOLELY RESPONSIBLE FOR, ANY AND AlL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTlONS. WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SEllER'S EXCLUSIVE UABILITY FOR ANY AND AlL CLAIMS, 

LOSSES, DAMAGES. OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT. NEGLIGENCE. STRICT lIABILITY IN TORT OR OTHERWISE SHALL BE UMITED. ATTHE MANUFACTURER'S OPllON. 

TO REPlACEMENT OF. OR THE REPAYMENT OF THE PURCHASE PRICE FOR, THE OUANTITY OF PRODUCT WITH RESPECTTO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SElleR BE LIABLE FOR SPECIAl.. INDIRECT OR 

• CONSEOIJENTW. DAMAGES RESULTlNG FROM THE USE OR HANDlING OF THIS PRODUCT. 

Rh6no-Poukmc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

ROS&arCh Trianglo Palk, North Carolina 2n09 

PREP Is a trademark of RHONE..pQULENC. 

PREpn. brand Ethophon Plant Regulator for Collon (PENDING) Submitted 1/16196. 

. ... • • •••• 

• • •••• •• 

• 

•••••• • • •• 

• • ••• 

•••••• • • 

•• 

•••• • • • • •••• 

•• • • •• 

• • • •• • ••• 

• •• •• • •••• 

•••• 

• •• •• • 

59 
DP BARCODE, D233644 

CASE, 003340 

SUBMISSION, S499336 

DATA PACKAGE RECORD 

BEAN SHEET 

DATE, 02/21/97 

Page 1 of 1 

CASE TYPE, 

RANKING 

CHEMICALS, 

* * * CASE/SUBMISSION INFORMATION * * * 

REGISTRATION 

o POINTS () 

099801 Ethephon 

ACTION, 674 8 MNTH RESP-PROD SPC DATA 

ID#, 000264-00380 PREP PLANT REGULATOR FOR COTTON 

COMPANY, 000264 RHONE-POULENC AG COMPANY 

39.9000~ 

PRODUCT MANAGER, 25 PHILIP ERRICO 703-305-6027 ROOM, CM2 241 

PM TEAM REVIEWER, WANDA RUFFIN DAUGHTRY 703-308-8171 ROOM, CS1 1K4 

RECEIVED DATE, 01/23/96 DUE OUT DATE, 07/21/96 

* * * DATA PACKAGE INFORMATION * * * 

~ BARCODE, 233644 EXPEDITE, N DATE SENT, 02/21/97 DATE RET., / / 

HEMlCAL: 099801 Ethephon 

DP TYPE, 001 Submission Related Data Package 

CSF, Y LABEL, Y 

ASSIGNED TO DATE IN DATE OUT ADMIN DUE DATE, OS/22/97 

DIV , 

BRAN, 

SECT, 

REVR , CONTR, 

• 

DP BC 

226724 

226726 

RD / / / / NEGOT DATE, / 

FHB / / / / PROJ DATE, / 

PMT-22 / / / / 

/ / / / 

/ / / / 

* * * DATA REVIEW INSTRUCTIONS * * * 

This product is recommended for reregistration upon your 

final review of label for compliance with Ethephon RED. 

After label review, please close this data package 

submission as well as the 674 submission with a 

reregistration decision and file all correspondence in the 

product jacket. Thanks 

Attached: 

correspondence/administrative 

product chemistry/acute tox reviews 

* * * DATA PACKAGE EVALUATION * * * 

No evaluation is written for this data package 

* * * ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION * * * 

BRANCH/SECTION 

RSB/PCRS 

RSB/PRS 

DATE OUT 

05/31/96 

05/31/96 

DUE BACK 

08/29/96 

08/29/96 

INS 

Y 

Y 

CSF 

Y 

Y 

/ 

/ 

60 

LABEL 

Y 

Y 
.. 

• 

• 

. ' 

DATil ODT. NOV 1 ~ 199, 

SUlIJIICT. III' [X] lIP [] PIIDDUCT CllBHIBHY ItBVIBlf 

DP BARCODB~jUiO~'iiilil:;~;;~ll~~~;;;;~~;::;l!l!ii RBGIBTIIATIOU 

PRODUCT: 

DID 

TO: 22 Cynthia Giles-Parker/Wanda Ruffin Daughtry 

Fungicide-Herbicide Branch 

Registration Division (7505C) 

PROIl. Sami Malak, Chemist, 11/12/96 {308-8392)~/111~ Product Chemistry Review Section { '>/ \<.-

Registration support Branch/RD (7505W) . a .r" I' I "..L. (;J 11-'-' jJ..( Harold Podall, Section Head /);J I. ~Qj) p~ Product Chemistry Review Section ~ (tvTBRU, 

1IIiI1IIIGS: 

1. The submitted product ch~mistry data requirements for 

reregistration of this end-use product, Ethrel Brand Ethephon 

Plant Regulator For Cotton, Reg. No. 264-380, is adequate. 

2. Product chemistry data requirements pertaining to Series 63, 

summarized in the table below, is adequate. 

3. The submitted product's label EPA received 1/23/96, is 

acceptable . 

4. The submitted product's CSF, a basic formulation dated 

12/19/95 is acceptable. 

All ingredients are cleared for use in pesticide formulations. 

RlCOHHEHPATIONS: 

We have no objections to reregister this end-use product, Ethrel 

Brand Ethephon Plant Regulator For Cotton, Reg. No. 264-380. 

7S0SU:RD:RSB:PCRS:CS-1:65D:S.Malak:ll/12/96:703-308-8J92:<264-380>. 

61 
• 

• 

2 

SUMMARY OF PRODUCT CHEMlSTRYDATA REQUIREMENTS OF SERIES 63 

PHYSICAL/CHEMICAL PROPERTIES. MRID No. 439205-07 

Gu/DELINE VALUE OR QUALITATIVE DESCRIPTION 

REFERENCE NO/TITLE 

63·2 Color Waterc/ear 

63-3 Physical Stale Free flowing liquid. 

63-4 Odor Odorless 

63-7 Densily. Bulk Densily. 1.2070 

or Specific Gravily 

63-12 pH 2.03 

63-14 Oxidizing Or Does not contain oxidizing or reducing agents. 

Reducing Action 

63-15 F1ammabililyl Flame NA 

Extension 

63-16 ExpIodabilily Does not contain any explosive materials 

63-17 Storage Stability Stable for a minimum of 2.5 years. 

63-18 Viscosily 3.331 cSt . 

63-19 Miscibilily (With NA 

hydrocarlxm 

Solvents) 

63-20 Corrosion Non cOlTOsive to stainless steel or plastic. Slight corrosion 

Characteristics to mild steel and aluminum. 

63-21 Dielectric Breakdown NA 

Voltage (EP only). 

eel Sam! Malak and Central file (Reg. No. 264-380). 

75051./: RD: RSB :PCRS: CS-l :650: SMa l al::: 11/12/96: 703-308-8392: <264·380>. 

62 
OP BARCODE: 0226724 

CASE: 003340 

SUBMISSION: S499336 

DATA PACKAGE RECORD 

BEAN SHEET 

* * * CASE/SUBMISSION INFORMATION * * * 

DATE: 05/31/96 

page 1 of 1 

CASE TYPE: REGISTRATION ACTION: 674 8 JINTH RESP-PROO SPC DATA 

RANKING : 

CHEMICALS: 

o POINTS 0 

099801 Ethephon 

IO': 000264-00380 PREP PLANT REGULATOR FOR COTTON 

COMPANY: 000264 RHONE-POULENC AG COMPANY 

39.9000% 

PRODUCT MANAGER: 25 ROBERT TAYLOR 703-305-6800 ROOM: CM2 241 

PM TEAM REVIEWER: WANDA RUFFIN DAUGHTRY 703-308-8171 ROOM: CSl lK4 

RECEIVED DATE: 01/23/96 DUE OUT DATE: 07/21/96 

• * * DATA PACKAGE INFORMATION * * * 

DP BARCODE: 226724 EXPEDITE: N DATE SENT: 05/31/96 DATE RET.: / / 

CHEMICAL: 099801 Ethephon 

CSF: Y LABEL: Y t TYPE: 001 Submission Related Data Package 

SIGNED TO DATE IN DATE OUT ADMIN DUE 

NEGOT 

PROJ 

DATE: 08/29/96 

DIV:RD // // 

BRAN: RSB / / / / 

SECT: PCRS / / / / 

DATE: 

DATE: ~ ~ REVR: // // 

CONTR: / / / / 

• 

OP BC 

* * * DATA REVIEW INSTRUCTIONS * * * 

Please complete 8 month reregistration review of data for 

product under Ethephon RED (0382). Thanks 

Citing MRID 43920507 for series 61, 62, and 63 (data attached to 0226722 (product 264-257» 

PLEASE RETURN TO W.DAUGHTRY, CS1, 3RD FLOOR, SRRD-7508W 

* * * DATA PACKAGE EVALUATION * * * 

No evaluation is written for this data package 

• • * ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION • • • 

BRANCH/SECTION DATE OUT DUE BACK INS CSF 

63 

LABEL 
. , 

• 

• 

• 

-_._--------------

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 204G0 

MEMORANDUM 

OFFICE OF 

PREVENTION, PESTICIOESAND 

TOXIC SUBSTANCES 

Subject, EPA File Symbols, 264-263(0226719), 264-543(0226721), 

264-267(0226711), 264-292(0226717), 264-376(0226715), 

264-257 (0226723), 264-377 (0226729), 264-380 (0226726) , 

264-418(0226709) & 264-511(0226706) 

From: 

To: 

Mark J. Perry, Biologist 

Precautionary Review Section 

Registration Support Branch 

Registration Division (750SW) 

Wanda Ruffin Daughtry 

Special Review and Reregistration Division (7S08W) 

Applicant:Rhone Poulenc Ag Company 

P.O. Box 12014 

2 T.W. Alexander Drive 

Research Triangle Park, NC 27709 

BACKGROUND 

Rhone Poulenc Ag Company has submitted or cited acute data 

for several products (listed above) in response to the Ethephon 

RED. The products are addressed in accordance with the acute 

toxicity bat ching strategy included in the RED document. 

Ethephon is a plant growth regulator used to promote fruit 

ripening, flower induction and other similar responses from 

treated plants. 

RECOMMENDATIONS 

Batch 1: EPA Reg. Nos. 264-263 & 264-543 

81-1, Category IV (MRIO 439205-01*) 

81-2, Category III (MRIO 439205-03*) 

81-3: Category IV (Based on Technical) 

81-4, Category III (MRIO 418674-01) 

81-5, Category IV (MRIO 418015-01) 

81-6: Non-sensitizer (Based on Technical) 

* MRID 439205-01 and 439205-03 received an abbreviated review 

to the results of the acute oral and dermal testing on 

technical Ethephon. 

due 

64 
• 

• 

Batch 2, EPA Reg. Nos. 264-267, 264-292 & 264-376 

81-1, Category III (MRID 439205-02*) 

81-2, Category III (MRID'439205-03*) 

81-3: Category IV (based on Technical) 

81-4, 

The eye irritation study cited to support this requirement 

cannot be located (MRID 00070086). As a result, 81-4 is a data 

gap for· the batch 2 products listed above. The registrant may 

choose to submit a copy of the cited document for review, or cite 

alternative eye irritation data to support reregistration of the 

products in this batch. 

81-5, Category III (MRID 00251542) 

81-6: Non-sensitizer (Based on Technical) 

* MRIDs 439205-02 and 439205-03 received abbreviated reviews due 

to the results of the acute oral and dermal testing on 

technical Ethephon. ",_,,_~ __ ~'_~~"__ . ------- --~'''' 

Batch 3, EPA Reg. Nos. 264-257, 264-37~264-38~ 

81-1: Category III (Based on TeChn~ 81-2: Category III (Based on Technical) 

81-3: Category IV (Based on Technical) 

81-4, Category I (MRID 00248658) 

81-5, Category II (MRID 00251542 & 00248658) 

81-6: Non-sensitizer (Based on Technical) 

Batch 4:' EPA Reg. Nos. 264-418 

81-1: Category III (Based on Technical) 

81-2: Category III (Based on Technical) 

81-3: Category IV (Based on Technical) 

81-4: Category I (MRID 00248658) 

Due to the category I eye irritation observed in a 39.9% 

batch 3 product (MRID 00248658), PRS has decided to use this 

study to support the subject (55.4%) product. 

81-5, Category I (MRID 428727-01) 

81-.6: Non-sensitizer (Based on Technical) 

Batch 5, EPA Reg. Nos. 264-511 

81-1: Category III (Based on Technical) 

81-2: Category III (Based on Technical) 

81-3: Category IV (Based on Technical) 

81-4: Category I 

Requirement waived due to expected severity of eye 

65 
-:----~--------------c___------------------------

• 

irritation testing results. 

81-5: Category I (MRID 00029513) 

81-6: Non-sensitizer (Based on Technical) 

LABELING 

Batch 1: 

1. The recommended signal word is caution. 

2. The recommended precautionary statements are as follows: 

Harmful if absorbed through skin. Causes moderate-eye 

irritation. Avoid contact with eyes, skin or clothing. Wear 

long-sleeved shirt and long pants, socks and shoes and chemical 

resistant gloves (such as Nitrile, Butyl, Neoprene, and/or 

Barrier Laminate). Wash thoroughly with soap and water after 

handling. 

3. The recommended statements' of practical treatment are as 

follows: 

IF ON SKIN: Wash with plenty of soap and water', Get medical 

attention. 

IF IN EYES: 

physician if 

Batch 2 

Flush eyes with plenty of water. 

irritation persists. 

Call a 

~ 1. The recommended signal word is caution. 

2. The recommended precautionary statements are as follows: 

Harmful if swallowed or absorbed through skin. Avoid 

contact with eyes, skin or clothing. Wear long-sleeved shi~t and 

long pants, socks and shoes and chemical resistant gloves (such 

as Nitrile, Butyl, Neoprene, and/or Barrier Laminate). Wash 

thoroughly with soap and water after handling. 

3. The recommended statements of practical treatment are as 

follows: 

IF SWALLOWED: Call a physician or Poison Control Center. 

Drink 1 or 2 glasses of water and induce vomiting by 

touching back of throat with finger. If person is 

unconscious, do not give anything by mouth and do not induce 

vomiting. 

IF ON SKIN: Wash with plenty of soap and water. Get medical 

attention. 

66 
, 

I' 

/~ ----~ '\ 

(~ Batch 3 ' 

~:ducts in this batch meet the criteria for res~ricted use classification due to eye irritation. The PM Team should 

decide if restricted use classification is necessary or if 

alternative labeling will allay the requirement for restricted 

use classification. 

2. The recommended signal word is danger/peligro. 

3. The recommended precautionary statements are as follows: 

• Corrosive. Causes irreversible eye damage and skin 

irritation. Harmful if swallowed or absorbed through skin. Do 

not get in eyes, on skin or on clothing. Avoid contact with 

skin. Wear coveralls worn over short-sleeved shirt and short 

pants, socks and chemical resistant footwear, goggles or face 

shield and chemical resistant gloves (such as Nitrile, Butyl, 

Neoprene, and/or Barrier Laminate). Wash thoroughly with soap 

and water after handling. Remove contaminated clothing and wash 

clothing before reuse. 

4. The recommended statements of practical treatment are as 

follows: 

IF SWALLOWED: Call a physician or Poison Control Center. 

Do not induce vomiting. Drink promptly a large quantity of 

milk, egg whites, gelatin solution, or if these are not 

available, drink large quantities or water. Avoid alcohol. 

IF ON SKIN: Wash with plenty of soap and water. Get medical 

attention. 

IF IN BYES: Hold eyelids open and flush with steady, gentle 

stream of water for 15 minutes. Get medical attention. 

5. NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate 

the use of gastric lavage. 

Batch 4 

1. The products in this batch meet the criteria for restricted 

use classification due to eye irritation. The PM Team should 

decide if restricted use classification is necessary or if 

alternative labeling will allay the requirement for restricted 

use classification. 

2. The recommended signal word is danger/peligro. 

67 
• 

3. The recommended precautionary statements are as follows: 

Corrosive. Causes irreversible eye damage or skin burns. 

Harmful if swallowed or absorbed through skin. Do not get in 

eyes, on skin or on clothing. Wear coveralls oVer long-sleeved 

shirt and long pants, socks and chemical resistant footwear, 

goggles' or face shield- and chemical resistant gloves (such as 

Nitrile, Butyl, Neoprene, "and/or Barrier Laminate). ·Wash 

thoroughly with soap and water after handling. Remove 

contaminated clothing and wash clothing before reuse. 

4. The recommended statements of practical treatment are as 

follows: 

IF SWALLOWED: Call a physician or Poison Control Center. 

Do not induce vomiting. Drink promptly a large quantity of 

milk, egg whites, gelatin solution, or if these are not 

available, drink large quantities of water. Avoid alcohol. 

IF ON SKIN: Wash with plenty of soap and water. Get medical 

attention. 

IF IN EYES: Hold eyelids open and flush with steady, gentle 

stream of water for 15 minutes. Get medical attention. 

5. NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate 

the use· of gastric lavage. 

Batch 5 

1. The recommended signal word is danger. 

2. The recommended precautionary statements are as follows": 

Corrosive. Causes irreversible eye damage or skin burns. 

Harmful if swallowed or absorbed through skin. Do not get in 

eyes, on skin or on clothing. Wear goggles or face shield. Wear 

protective clothing and rubber gloves. Wash thoroughly with soap 

and water after handling. Remove contaminated clothing and wash 

clothing before reuse. 

3. The recommended statements of practical treatment are as 

follows: 

IF SWALLOWED: Call a physician or Poison Control Center. 

Do not induce vomiting. Drink promptly a large quantity of 

milk, egg whites, gelatin solution, or if these are not 

available, drink large quantities of water. Avoid alcohol. 

IF ON SKIN: Wash with plenty of soap and water. Get medical 

attention. 

IF IN EYES: Hold eyelids open and flush with steady, gentle 

68 
, 

~. 

• 

• 

• 

stream of water for 15 minutes. Get medical attention. 

4. NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate 

the use of gastric lavage . 

69 
--~~~~--------~~-------------------

DP BARCODE: D226726 

CASE: 003340 DATA PACKAGE RECORD DATE: 05/31/96 

SUBMISSION: 5499336 BEAN SHEET page 1 of 1 

* * * CASE/SUBMISSION INFORMATION * * * 

CASE TYPE: REGISTRATION ACTION: 674 8 lIN'l'Il liESP-PROD SPC DATA 

RANKING : 

CHEMICAIS : 

o POINTS () 

099801 Ethephon 39.9000% 

IDt: 000264-00380 PREP PLANT REGULATOR FOR COTTON 

COMPANY: 000264 lUIONE-POULENC AG COMPANY 

PRODUCT MANAGER: 25 ROBERT TAYLOR 703-305-6800 ROOM: CM2 241 

PM TEAM REVIEWER: WANDA RUFFIN DAUGHTRY 703-308-8171 ROOM: CSl 1K4 

RECEIVED DATE: 01/23/96 DUE OUT DATE: 07/21/96 

• • * DATA PACKAGE INFORMATION * * * 

DP BARCODE: 226726 EXPEDITE: N DATE SENT: 05/31/96 DATE RET.: / 

CHEMICAL: 099801 Ethephon 

• 

TYPE: 001 Submission Related Data Package 

CSF: Y LABEL: Y 

ASSIGNED TO DATE IN DATE OUT 

DIV:RD // // 

ADMIN DUE DATE: 

NEGOT DATE: 

08/29/96 

/ / 

BRAN: RSB / / / / 

SECT: PRS / / / / 

PROJ DATE: / / 

REVR: // // 

CONTR: / / / / 

* • * DATA REVIEW INSTRUCTIONS * * * 

Please complete 8 month reregistration review of data for 

product under Ethephon RED (0382). Thanka 

81-1 and 81-2 citing KRIDs 00116670 and 00248658 

81-3 and 81-6 citing KRIDs 00138194 and 00252901 

81-4 citing MRIDs 00116670 and 00248658 

81-5 citing KRID 000159531 

_ ) PLEASE RETUlUl TO W. DAUGHTRY, CS1, 3RD FLOOR, SRRD-7508W 

• * * DATA PACKAGE EVALUATION * * * 

No evaluation is written for this data package 

* * * ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION • * * 

DP BC 

226724 

BRANCH/SECTION 

RSB/PCRS 

DATE OUT 

05/31/96 

DUE BACK 

08/29/96 

INS 

Y 

CSF 

Y 

70 

/ 

LABEL 

Y 
FEB-.29-19% 17:22 FR0l1 OPP/SRRD/IO TO -- -

UnitGd States Envtronmentet Protection Agency Form Approved 

W.uhin01On. DC 20460 OM8 No. 2070-

0107, 

CERTIFICATION WITH RESPiCT TO 2070-0057 . . DATA COMPENSATION REQUIREMENTS Appro,,·.1 EXiJiru.s 

. 3-31-98 

PubU~ rltporting burden fot ~hle oolleotion of IntorTnDtlon is Mtimatod to avOnlgo 16 minut\t4 par roopcnco. including timo tot 

r(Mowing trlsttuctions, searching exiSting data sourc ... oath"'g and maintaining the data needed, and cOmpjtrling- and 

reviewing the l;oUection Of informatiOn. Send Commeotl rtQ8railO ttle burdon 'OStinite or any other atpeci of this collection 

of infonnatloo. includinO &UOgeations for reducing this bUtdan to. Ch ... Imorma1.ion Polley Branch. PM-233. U.S. 

EnvironrMOtll Protection Agency, 401 M St., S.W., Wnhnuton. DC 20460; and to the Office of Mlnagemam: anti Budget, 

Paperwork Reduction Project f207(}-010(H, Wuhington, DC 20603. 

PI .... fill in blanb balow. 

C......,I"YN ........ C""""' • ..., Numo., 

Rhone-Pou1 enc Ag Company 264 . , , PrMuetN_ EPA Rq. No. 

• 

PREpHi brand Ethephon Pl ant Regulator' for Cotton 380 

I C","" that, 

1- For eaCh rtt.lI:iy cited in SUpport of registration or reregistTe1iion under the Federallnseetioide, Fungicide end Rodenticide 

Act fFIFAAI that it an exclusive use I'tUdy, I am the anginal data submitter, or I have obtained the written pmmiasion of the 

Original data submitter to cite ttat S\lIdy. 

2. That fot each study cited In support of ragistration or hltegiablation under FlFRA that" NOT an excluslv1! use study, I 

am the original data submitter, or I have obtained the writt..-. permiasion of the original data submitter, or I have notified in 

writing the companyfles) that .submitted data I have cited and hove otferedto: (a} Pay compensation for those data in 

accoraaneo Wrth SectIons 31cU1 )lFI and 3fcIl2}ID) 01 FIFRA; ana (bl commence negOtiatiOn to dBtemWla which data are 

subject to the compensatiOn requirement of FIFRA and the amount Of compensation due, it any. The companies I have 

notftied are. {Check omtl 

[ 1 The companies who have 8\lbmltted the studies fitrttd on the back of thia form or attached sheets, or indicated on the 

attached -Requirements StatU. and Rl!9~rat'lts' RasponH Form," 

3_ That" I have previou.1y compUed with seetlon 31c)!1 )lFI of FIFRA for the Irt\fdles I han cited In support ot tegistration or 

reregistration under FIFRA . 

. . - .. _ .. -. 

.... M. f:!7 V Date 

/~~/ JI;~J[.g 3~9J(;- t 

Name lind TIti. 11'1 ..... Typ. or !"tintl 

Gail POI'le 11 , Registration Manager • , " 

QENEAAL OFFER TO PAY. I hontbyoffm' and agree to pay oomponution to othor panlon$, with rtlClilrd to tho 

registration or reregistrltion of my products, to the extent requirad by F1FRA section 3lel(l)1F! and 3Ic)(2ItDI. 

SlgllllIWO:O 

~,f' f~dL O~. 

. 3//7/7(,-. .. {~~ 

NIrM ~ TItio \1'1_. Type or t'l'mU 

Gail Powell, Registration f~anager - - "I'A ....,.. " , 

71 
• 

) 

EPA File S""",,'/Rea. No. _-,2~6!:j4c:-~38"\lQ!::-:--,-_ nate of acolieat.lal ____ _ 

"n~ E"tl'~t'I<.< ..... 

~ of Prt:duet: _.!:P.!lR .. EPl:.t;:.m::..-...... ~ft:.1J.jaunut;..J1Re~gwtLJ!J"'a"'tlloc.c..;ft.co"rc...!,;Coo.tt;tt.<o""'-______ _ 

ADclicant"s Name and Aclc.1ress RhOne-Ppplen, 49 Gompan,y 

P. O. Box 12014 

Research Icj aog] e Park ~I C 27709 

1. This 8C'Pllcat.ion is ~ by all data 1NtDit.~ or cited in the 

appUea.t.icn. In addit.ion, it: eiee-all t:::Ipeions are irxSicat.ed, this applic:adcn 

is ~rud by all datA in the Jqctncy's fil_ that eonc:em t.he Pt'CPGIrtlU 

or effectS of this tmXIuc1: or ot any oeMr grcduc:t:. dlat is ident:lc:a.l or 

auDatantially similar. and that. is CInIt of the types of data that would be 

raquirac1 to be 1lUtlDit.tec1 it: this applicat.icn ac:u;tlt t:M init.ial 1"8Qutnt.ion 

ot: a. p~ of identical or similar CUllY atUm ana intended WIH urdar 

the dat.a requirlDlna in effect. en 't.hII date of awzwal of this a;IIPlicadon. 

2. I certify that. for eech st:u::Sy cited in supoott of this applieat.ion 

for registn.tion tttac is an eXCllJlilVWl use s'tUdy, I have obtained t.lote 

written plu:raiuicn of the ori;inAl data s\.'l:mit.ur to cit.. that. Stu::tva 

3. r certify t.hat.~ for each study cited In S1.JCXIC)n of this a;o.licacion 

for regUtration that. is ~ an nelusiVlt use atu:!y: 

I have obtained t.~. woritten pemissicn of the cr:iQinal data sutrait.t.er 

too cit.. that. s:u::ty; ~ 

t have not,ified in wridn;r the ~.s who turve ll'Ul:nit.ted r!at:.a I have 

cit.ed to sucoor1: this acpUc:auon ancl havtt oUend to:- (al pay ~nsat.ion 

for thoH data In .=- vith _Ial 3(c)(1)(D) arrl 3(c)(2)(0) at 

tile "-ral I_lcide. IWglcicSe arrl __ icicle Act. arrl (bl OJ .... "'" 

negoeiaticn:l to detemine which data an SUbject to the cuew .... t.icn 

requitalWflt. of !'1'FRA and the 1IIIOUnt. ard tea. of cuupanaat.1cn Qua~ if 

any. 'Iba Cl2llpraftiea t have ncxified arel (0Wck cnel 

f\.(l All e:zapanies listed en the Pesticide Data Sutm1t.t.ers L1st. tor 

all aetive in;ndienu c:onuined in my pra:fuct. (Cite-4ll1'DKhod or 

cit..e-llU opt..1cn un:ktr selecc.iw Mtthod). (Also sian the General 

Offer t.o Pay Statmane belc:N.) 

{>4 nx..~ .. _ haw _tted the at:u<!l .. vlUch I _ 

ciuct (Seleccive m.ChI:::d) 

SlQnature "'G",~;.,c;;;;:ow~e~f~:d/~,-----.... 

• • Title .R~e~gUijslttra~tliuo~n~M~anw.~gue~r~ ____ ~ •••• 

ext.ent. AqUind ~ 

DI.. I z../zq iT, , 

- . . 

•••••• • 

... •••• S!ana""" _L.~:L~~:W.":'. __ 

Title &,1> &$.-.. jlfwtj'-'V: '::-

(.11 19851 

•••• • •• •• • 

72 
. "'" . .. ,,"', .f.~ . Fo~ OMS N,. 2070.0060. . 0"".'. 

United StatU, B Registration opp Identifial Numb., 

oEPA Environmental Protection Agency Amendment 

Wll4hillQton, DC 20460 251317 . Other 

. Application for Pesticide - Section I 

1. CompanylProduct Number 2. EPA Product Monage, 3, Propoeod Classification 

264-380 Theresa Stowe I1J NollO D RD81licted 

4, comPlnVlProtu~~~E~ PM' 

PREptm "dJ" i ~;~:iI Jl.TnD FnR #22 

5. Namll and Addr ... of Applicant (lncludo ZIP Coda} 6. Expedited Review. In accordance with FtFRA Section 3(c)(3) 

Rhone-Poulenc Ag Company lb)(i), my product Is similar or Idenilcalln composition and labeling 

P,O. Box 12014 to: 

Research Triangle Park. NC 27709 EPA Reg. No. 

D CIm:k. if tills /$. ntlw tJdrhou Product Name 

Section - II 

~ Am'''''~"t· .,.",," ,.,w. 0 Fine! printed label. in ,.upons, to 

Agency 'ettor dated 

R •• ubminion In rlapornro 10 Agency leue, dDlsd 0 -Me Too· AppUoalfon. 

D Notificlltion ~ Explain bolow. 0 Olh" - ExplDin holow. 

Explanation: Us, additional psoai.) If Moenery. (For sictlon I end S.cllon II.) 

Revisions to label as required by Ethephon RED. Aprifl 28. 1995. Move 2 paragraphs from 

"General Information" section to "Equipment Cleaning" section. Add "Use Limitations" section. 

Added "brand Ethephon u to product name. 

Section - III 

1. Mate". Thk Product WiD a. Packagod In: 

Child·Resistant Psokeglng Unit Paokeging Wate' Soluble Packagilll1 2. Typo of Conte/nor 

• 8::" - Yn r- Yes 

~~t • 

~ N, k:: N, ptutio 

Gle .. 

• CertiflCIltion must If "Yee" No. per If "Yes~ No. po, Peper 

Unlt Packaging wgt. container Peok.ge wgt oonlaino' Other ISp.olly) btl submltted 

, 

3. Location of Not Conlentl: Information 4. Sizels) Relail Container 5~tiOn of Label OiroctioM 

GJ Lob_ O Containor .? '.5.0.30. 110 Q.11on· 

4 Onlabol 

On labeling acoompenying produot 

B. Manner in Which Labol is Affbcod to Product 

~ Uthognwh Il.I Other glasti~ppe~ glued to container PIlP!r.Uod Ste . ed ins lab.l 

Seotlon - IV 

1, COnlect Point (Compt.,. itlfM dir.ctly b,/ow for idtmtilic.tion .f Indivldufll to b. tonracrod, if nO'cO$$my, to proCfIU thIs~" 

Namo Title Telephone No.~ ~ , 0 Area Code) 

Gail Powell Registration Manager 919/549- Wo. 

• 

Certification •••••• B. O.te ApPffcation • • • • "'''~ I certify thet the etluernents I hew made on this form end au ettachmonts therelo aro true. accurate and oOl'lflW ... 

I acknowledge tru.t any knowingly fGlso or mi.loading statomont may ba puni.hab!a by fino or imp"'onmant or. : • .. JStal"pedl both undar IIPfIlicabht law. " • • • •• •• 

2. Sigl'lOture~ . 3. Titlo • • 

(J~ ••••• • 

Registration Manager • •• • • • /' •••• 

4. Typed NAIM 5.0ato •••• • .. • • • 

Gail Powell 12/15/95 7':1. 

EPA Form 8670-1 (ft.v. 8 941 Previou. editioM era oiaolete. . WhIM • EPA Ph COpy lorlglnal) Yllow -Applicant Copy 
PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS , 

PAPERwDRK REDUCTION ACT NOTICE; 'PtJblic reporting burdan for thil coUocnon of informolion is utlm1)too to O\l(Hllll" 0.85 heur pw 

nlllpOnGO, Including tifnll for ra\'illwlng iustructionll. natchlng oxlsting dOll1 sources, gathering and muint,ulning thl!; data nellded. and ccmphning and '" 

H'\liowing tho collection of In/ormlltlon. Send C<mml1llltl fll9Atcllng the burdan ostimate or any other allpGct of lhill' collection of In/ormation, inclUding 

,uog8arlonll for reducing tI~8 burdon, to Chillf, lnf6rmotlon Policy ehmen, /21361. U.S. Environmantnl Protection Agency, 401 M Stroot, SW, • 

WOllhington, be 20460. 

INSTRUCTIONS; ThIll" form io to bo uaad for BlJ eppllcalion9 for now roglstration, and uso rereglstration. amendment, fOliUbmillllion, to applicatlonll 

for not/flooUon,_ final printod labollng, ror~gilltrotion, otc. In orum to process an npplicotion for a now registration submitted on this form, tM 

following materiel must aaoompany tho applicstion: 

1. Certlfioatlon with Ra4p8ct to CItation of Oato IEPA Form 8570·291. Ilf not oxempted by 40 CFR 152.81 ~bI14)J: 

2. Confidential Statomont of FormuialEPA Fotm 8510·41: 

3. Formulator', EXomption StetOMant (EPA Form 8510·271; 

4. Fi~ oopiee of draft IlIbeling; 

5. ThrOCl coplu of any data submitted; 

6. Authorb:ation letter whore oppJicllblo; 

7. Motnco. whero appllcablo. 

Submlsalon of Labellno· Lllbaling should fir61 bo IiUtsmltttd In the form of drillt Illbel' wilh all application. for now ragistration. Such draft llibels may ba 

In tM form of typed looe! text on 8.5 x 11 inch P3pIU for submilllion or a mockup of the proposed lob~. If proparad for moekup, it should be 

constructed in a way os to facilitQto 5tOragO in an 0.5 It: 11 Inch /lilt, Mockup Iltbelt signiflcantly smollar than 0.5 x 11 Incho •• h9uld bo mountltd on'8.5 

x 11 inch p.por for IIubmiulon. '" • 

SubmIssion of D.~· Data submittad in IiUpport 01 tlli. application muol be .ubmittod in occordlln<:o with PR Notice 86-5. 

SPECIFIC INSTRUCTIONS; Pluse road tho in$lructions listed below boloro completing tiliG .pplicotion. Firet dotom\ine}M type of fogistration 

action, listed in Block A, for y.'hich you ora lIubrnitting this application. For applications Gubmittlld In cormection with New Ragistrotion actions, Sections 

I, lll, and IV mUDt be ccmp/etod by tho applicant. For spplicotionll submitted In connection with omanded rar8giDtration fictions, reeubmhrslon., 

notifications, rerogistrations. etc., Sections I, II, tmd IV mu.t be completed by tho applicant, 

810ck A • Chock the appr6prlate lIetion for which you aro SUbmIttIng this f0tl'!". 

SECTION I· Thi. section muSt DO comp/OIod, tiS app/icabltf, for all regi,mauon eotion,. 

I. Compenyll'roduet Number -Insert your Company Number, if OlIO hes been ossigned by EPA. This number may hava b8lln allll:ignad to you ell a 

bllsic reo/slront. iI dilltributor, or os an IUltabllshm"nt. tf your proouct I~ registared, inurt the Product Number. 

2. EPA Product Manager· If known, fill in tM Mmll and PM nUmber,of th(l EPA Product M(lnogllr. 

3. Proposed Claoslliootion ~ Spacl/y tho proposed olonification of this product. 

4. Product Name· Entor tha eol1'TP1ate product name of thi,l pullcide'olll! will appear on the labal, Tha name fTltjU ba apeoific to this prodUct onlV. 

Duplication of nllffi\ts Is not pllnniUed ~ong products of tho 'l101,e COl)1pllny_ 00 not includa eny brand nllll\U or IXilnflllny IiftO dollignationc. 

5. NOIM ,end Add ... " of Applicant - nle name of the frrm or pe($On and /lddrlul$ chown in your application i. th. pefson or firm to whom the 

rogisttlltion ..... UI be issued. If you ~e aoting in behslf oillnothor party, you mu&! submit ouilioritlltion from that party to act for tham In rogi$tration 

mstto,.. An applioant not re61ding in tho United StataD mu.t have an authorlled agent reruding In tho Unitltd StatlHI to act for tham in eU 

r~stttltion mailers. Tho name and oompleto mailing address of ~uch an agent must accOffipilny this applicetion. • 

6. EXpadlted Remw· FlFRA section 3 (c) 3 lSI provldllli for oxpedited roview of applicatlO!1I1 1M reglstrlltlon, or amsndmel1l$ to existing roglltrati 

that are similor or identical to other pesticids products that are currently re\lh~tered with tho- EPA, In order for your application to be ollglble for 

expedited roview, you must provida UII with th(l EPA Rogi,~trlltion Numb,r and product namo' of the product you bellevo i. similer to or fdenticlllto 

your product. Tho product mu4t ba .imilar or Identieal in both formulation and labllled USOll. 

SECT10N II • TN. allctlon must b~ completod for 8U applications submluad to emand tho raglirtr8tion only of 8 eurrently rogisterlld product 

IAmandmentl, for a resubmisolon In tOll.l1on"a to 8n Atl"'ncy lottur, for notlflcellofUI to th. Agoncy, for tho .\.Ibmltoion of final prlntlld leboling. for 

rafogi.trotion and for eny other ,ction thet perteins to II !!pgnifin EPA,'rJ1Qi"'torad prpduct. Thls "ction Is!l2! 12!!.!! !,l.ad for. new eppllcetlen for 

rllgistr.llan. 

1. SubJeot of IIUbml=lIi!)!1 • Chol:lk tha opplic6We block and provide lhll Agency loltllr dete If appropriato. Providll it brief oxplllnlltlon of the purposols) 

for the lIubmis$ion, sueh as ~th!l addition of II sito, peot or orop l,peclfYI·~ "amend the Confidontial Statement of Formula by ... ·; "roregistretion 

illUbmis1lion~; "oonorelleblli r,vision of use direotions." Attoch b .oparote page if additional spaoe is neoded • .... , 

SECTION lII"1i'.~T$ng and Contniner Informlltionl' Thill Section must ba completed for aU appliClltionD llubmiUod in cOMaction with n,w 

raQiatretion cf ~abla amandments. 

1. TYf}O of Pe&'"4lIh\:- Chock tlltl nppropriote block If your product will bu packngod in tho indicated packugiug typos. 

Indicete the sl,. of the ln4lvl"'tlli,packets and number per retail eontalnor. 

2. Typo of Rettlf Corleinor '3nd'katl type of container in which product will bo marketed. 

3. Location of.a.tCc.rtonte: ;, ~~cl~o the location of the not content, informetion for your product. 

4, Slze(.1 m n.t.lCootamw.- '~mfy tho net contonts of all r,tlill contllintlrs fOf your product. 

5. LocetiOfl of",." triIl'H:UCfH; !rndlcoto tho locotion of the U$U dirsclions for your product. 

S, MaMaf in ~fala1 r.-' 1Il1M4t"tt product - Indicated ttle m$thod prodUct lobelis nttachad to retail eontainar . 

• ••• •• 

SECTION IY,IUgt4t Pmn!) - Thle S"ot/on ml.n.t be compluted for cllapPUcQtloM for Registrlltion actions. i."., new products registration. 

relR.tbml"lon, "ntdlM," reregi.tration, ete . 

•••• 1-5. Sl)/f·oxpIs,,~~ •• 

6. EPA Usa cSn!y_ • 

,..,. 
, '.m> '" OMSN •. 

&EPA Unltod States 

f- Roglstratlon 0" Identifier Number 

Environmental Protection Agency ~ Amendment 251317 i Wo~"llngton. DC 20460 . Other 

, I for I' , I 

1. Company/Product Numb., 2. EPA Produot Manager 3. Proposed CI ... Uicatlon 

264-380 Stowe E1None D Ra.trictod 

\1\(1'00 <IN'''1'' PM' 

. OR FilR CO TWN ¥22 

5. Namo ancLAddte .. of Applioant /lnclude ZIP Codo} 6. Expedited Review. In accordance with FIFRA Section 31e1l3) 

,{H011C ~ Priu 1 E'r)( "9 Company Ibllil, my product is similar or IdentiCal in composition and labeling 

;) ", SOX 12014 to, , • tl, 

:~est?nl.1 Tdangle Pal'l( , w; 21709 , EPA Reg. No. 

"A~ndm,"' - Exp'",. '''OW. 

• new addrllSS 

~ 

0 Final printed lebllls In rO'Pon .. to 

Allonoy letter dotod 

Resubmillion 1n raspon •• to Ageney lotter dated 0 ~M. Too· Appltcltion. 

0 Notification ~ Expleln below. 0 Other· explain balow • 

Explanation: UfO addldonal pagel.llf Mellllary. IFor .action land Sactlon 11.1 . Rev is j ons to 1 aD;:': i h$ i'0QU i ted hi E t!lephon , Iq.){ifi 2(1, J ~ 1<:(1'1(: 2 pafftgtofjf1 s f ,'OiL 

I 1 nformat i on" section to "Equipment Cleaning" section. Md "Usc' Llmftatlo[1s" 5<:;: T i 'Ai 

Add2d "LH'Jnd E t?l(,phon ,. to P(0GUCt flalf!? < 

,:ui 

! ,. .. 

Child·ReaiDlant Packaging ~r Soluble Packaging .. , .By ... r- y .. - Yes ...,~ 

it No t;: N. :;:: N. ::r PllOtic 

Glue I ~:y!,. No_ P" It ~Yo.~ No. par - Paper • CtN1Jfication must - blJ submlttlJd w",. Plckege wgt oontalnor - Other 

, "iil Lob: 0' No< I o Container 

14. 5i .. ,.jl 

.p=j o~o~ .. 

.2.".S.Q.3U !10,H;· • 

On oooompanying product 

6. Manner in Which lebella Afflxad to Product 

~ l!1 Other l>1,jSUc !i'~apqF!' ';!!Ii"'d ]. ",,.nl ;,,1;>' 

contains 1,bel 

,-IV 

,. Co."" P~.' , ""'. 

N"'11.11 i ' " Titlo 

rowe j ; ik'jlst.rfd.lofj (,1, ;1:', I~~ 

Certification . ~ , •. D,,, 

, """y that "" ... "~.,, , h~. mo" o. fm. I.m> 'M " ""',hm •• " f", .. f .... IN .......... ond " II acknowledge ~'~_, flllaa or millloadlno atatlmont may bo " 

both undor 

2. 5"M,",'~< . 3. Tltlo 

-

/ - • I ~.t :>.'(j\ ,:>t:'-Jt lon r\'\Hi'i:i<:;( ;,.:. 

14. Typod NIII'nII Is. D, .. .::;-, . ;; i '?;Yf'<C j i • : ';; ,i:' 71::. 

,8570-' IRoY.' ~.t. .- Cop, 
PAPERWORK REDUCTION ACT NOTICE !Il1d INSTRUCTIONS 

PAPERWORK REDUCTION ACT NOT(CE; Public reportIng burdfln for this collection of Information I.- olitimatlXi to 8W1'rlllg.o 0.a5 hour por 

rosponsa, Including limo for reviallifng [nlltructions, searching IIxh;ting dnta $oo(oea, gathering and maintaining tho data needed, and complClting and • 

reviewing tho oollection of Informotion. Sond COmmllnlS ragluding the hurdon oelimato or any other aspect of thIs tollaoilon of Information, Including ~ 

lIIuooostionl for reducing this burdon. to Chiof, Information Po~cy Stench, (2136). U,S. Environfnentlll Protoctian AOoncy, 401 M Str.ot, SW, 

Washington, DC 20400. 

INSTRUCTIONSi This form 10 to bo used for ell applications for n<lW (oghmotion. ond us. rerogisUation, /Ifl'loru.imont, tellubmisaioll. to applications 

for notificationl, final printod hlboling, rcregistretlon, ttc. In erdtr to proco,. tin IIppliclltion for a new rtlgilltration .ubmlnod on this ferm, tM 

following matariel mullt aocompany tha applicstion: 

1. Cartifloatlon With Ae$pact to Citation of Data IEPA Form 8570-29). (If not axampted by 40 CFR 152,81 Ib) 141): 

2. Confldentiel Statomont of FormulalEPA Form S570-41; 

3. Formulator'. Exomption Statoment tEPA Form 8570-271; 

4. Five ooplea of draft labeling: 

5. Th,.e eopia. of any date .ubmined: 

6. Authorization lener whore apprlCeble; 

7. Metrica. wMrd dppllcohle. 

$ubml5.lon of Labeling - Laballng should 'Ii,.t bo submitted in the form of draft labala with oll appIlcatlontl for new ragiatration. Such draft labals may bo 

in tho form of typod labo! text on 8.5 x 11 Inch paper for submission or a mockup of tha proposod labal. If preparod for mockup, It should ba 

COnfttuctad In e wsy .. to facililete storage In an 8.5 X 1 I inch filth Mockup lab 01. significantly smaller thun 8.5 x 11 Inches .hould be mounted o'_S 

x 11 Inch papor for .ubmhf8ion. 

Submls(i1on of Ootll- Data subminod in .upport of this application mus-t ba $ubmitted in accordance with PR Notioe 86·5. 

SPECIFIC INSTRUCTIONS; Plaasa read tha instructionslillted below befOUl comploting this application. fir,t datermino tha type of ragl$tratlon 

action. listed In Block A, for which you lUll submitting thi$ applicotion. For opplicatlonllllubmittod In connection wIth Naw Registration actioM, Sections 

I, III, and IV muat be completed by tho applicant. For applications aubmlned in connsction with amanded rareglstration II(:tlon$, ruubmluions, 

notifications, reregistrations, atc., Sactlons I, II, and IV must be completed by tho applicant. 

Block A· Chook tha appropriata action for which you ara wbmitting this form. 

SECTION (. This saction must ba complatad, as applicabla. for &/1 ragi$lration octionl. 

1. CompanylProduct Number -Insort your Company Numbor, if ona has boon auignad by EPA. Thi$ numbor may have boan oll$igned to you as a 

basic registrant, a distributor. or os en utablishmClnt. If your prodUct ia reglstarad, Incart tha Product Numbor. 

2. EPA Product Manager - )f known, fin In tho nomo and PM numbar of tha EPA Product Menager. 

3. PropOllod C1 ... lffcfltion - Spacify tho propooed olossificotion of this produot. i 

4. Product Name· Enter the complote prodUct neme of this posticide os it will appallr on tho lobel. Tho neme mull bo $peoific to this product only. I 

Oupllcetion of n&mes;s not pormittlld among products of the sama company. 00 not includa any brand nmno or company lina dsaignationll. 

S. Name Gnd Addr ... of Appllcnmt· The name of tho firm or fUilr!l:on ond JlddruslI shown In yD\lr application i, tho parson 0( firm to Whom the 

rllgistration will ba iswad. If you ere octing in behalf of anothar porty, you must submit IlUthori18Uon from that party to act for them in r(lgiotr ... ~'l 

mattere. An applicant not raliding in tho United Stateo must heve en authorized egent rasiding In the Unltad Statal to act for them In lJIl f, ) 

rogistretion monorl. Tha nama and comptate momng address of such Gn agent must acoompany this oppUcation. • 

6. Expedited Rovlow - FIFRA soction 3 Icl 3 tS) prov\dos for oxpedited revlow of appllcatio!UJ; for ragistrlltion, or 4I'nondmenU to axistlng roglstra 

that are timllar or klenticlJl to otllor potticido products that Ira currontly ragl$terlld with tho EPA. In ordor for your application to be IUg/bto for 

o>cpedhed review. you must provido us with the EPA Rogistration Number end product name of tho product you balja\l1l is dmllar to or idontical to 

yeur product. TIUI product mupt bo aimiler or idantical in both formulotlon and lobohtd u •••• 

SeCTION II • This .ootion must ba camp/otad for all applicetion. ,ubmitted to amend th. regi.tration only of ., currently regioterod product 

IAm,ndmant). for II rasubmisslon In rcspantls to en Agancy lottar, for notifieations to the Agoney. for ths IlUbmiealon of final printed laboling. for 

r.regiatration and for eny othor octlon tlUlt portaimr 10 IS 'P'IIcinc EPA'rogi$tllrnd prrn:!yc\. TW, ee<;:tion Is ruu 19..b.!. usod for IS now application for 

rogi$tretion. 

1. SubJeot of tubmiuioo - Chock tho oppHccble block and provida tho Agoncy lotter doto if appropriota. Provide 0 briof axplonotlon of tho purposol1l1 

for the sublnission, such Its ~tho IIddition of a sito, post or crop tlfpocilylW; ~amand tha Confldantial Slatemont of Formula by ... ~; "raragi,trotion 

submfstion~; ~"enor&l lobel revision of ulle diroctions." Attach a 1loparato page if additional spaca ill neadad • 

•••• 

SECTION IIrW.ihOijJng and Containu Information) - This Ssctlon must be complSlad for 1111 application$ submitted In connaction with new 

rogistration or ~ealille amendments. 

I. TvP. of pa!tuW;' Cheok the ilPpropriato block if your product wiN be packegod in the Indiceted peckeging tYPo •. 

Indicoto the'.q:o of tho In4iWlwai.pllcklits ond numblH por reUlii oontainar. 

2. Typo of Rotf» ~~ner ·,rn!icaJ) typo of contoiner in Which product will bo m9rkatod. 

3. LOlUltion oMt-U:~<I'tonto .~WIJ tho locotion of tho not contlJnts Information for your product. 

4. Slut,) of R.taH Contfllnel-- ~clfy tlUl not contGnts of aU rot&il oontainers for your product. 

5. Looution of.u .. &..ctione ~ fndilMtto tho location of tM uoo directions for your product. 

6. MenrIM In ~lIicll 1-bal la aln::tt:, product - Indicotad ths mothQd product labal is attllched to TOten contslnar. 

• • •••• 

SECTION IY.ttl,ta)t Peint)· This Section muet bo compiotlld for all oppli(:ationll for Regi.tratlon octionll, i.II., f\ilW productfl rl:lgilltrlltion. 

ruubmi.&ion, ~nVft:Ib,~ rl:lrogilltrauon, etc . 

•••• 

1-5. Self·.xvlaoa\tlr<t· 

G. EPA UN Only. 
• 

J 

CERTIFIED MAIL 

Gail Powell 

Registration Manager 

Rhone-Poulenc 

P.O. Box 12014 

, 

Research Triangle Park, NC 27709 

Subject: Ethephon Reregistration Eligibility Decision (RED), April 28, 1995 

Time Extension for Product Label Requirements 

Registration Numbers: 

Batch 1: 264-263, 264-543 

Batch 2: 264-267,264-292,264-376 

Batch 3: 264-257,264-377,264-380 

Dear Ms. Powell: 

Batch 4: 264-418 

Batch 5: 264-511 

All Ethephon products have been forwarded to the Registration Division (RD) for label 

review except for products which are in batch 2. The products in this batch will be forwarded 

to the RD upon receipt of the primary eye irritation review. In addition, you will need to 

submit additional information for registration number 264-267 as stated in the product 

chemistry review that was sent to you dated February 25, 1997. 

Your request has been granted for a time extension to make your labeling changes. 

The RED states that registrants may generally distribute and sell products bearing old 

labels/labeling for 26 months from the date of issuance and persons other than the registrant 

may generally distribute or sell such products for 50 months from issuance. Therefore, you 

are granted a 6 month extension to produce and use your new approved labels once you have 

received them from the Agency. Persons other than the registrant will be given 30 months 

after receipt of these approved labels to make the appropriate changes. 

MicroFlo was required to submit data as requested in the Ethephon RED since their 

products were registered within days of the RED issuance. MicroFlo has complied with 

the reregistrations required and are being processed along with Rhone-Poulenc's product 

77 
.- . '), 

• 

reregistrations. However, Griffin's products were registered after the RED issuance and 

therefore, are not subject to reregistration. 

If you have any additional questions, please call Wanda Daughtry at (703) 308-8171. 

cc: 

, 

Lois Rossi 

Barbara Briscoe 

Cynthia Giles~Parker 

Jim Stone 

Sincerely, 

/ '/ , 

Linda Propst, Chief 

Planning and Reregistration Branch 

Special Review and Reregistration Division 

78 

• 
~ 'RHONE-POULENC 

AHONE·POULENC AG COMPANY 

June 6, 1994 

ETH 94-12 

Document Processing Desk (FIN· LABELS) 

Office of Pesticide Programs 

Room 266A, Crystal Mall 2 

1921 Jefferson Davis Highway 

Arlington, VA 22202 

Attention Mr. Jim Tompkins 

Registration Support Branch 

e Oem Mr. Tompkins: 

• 

RE: Fimli Labels for PREP Plant l~egulator for Cotton 

EPA Reg. No. 264-380 

Your letter of accept<1IlCe dated May 31,1994 

Appended is one copy of the final Labeling for PREP Plant Regulator for Cotton. There 

was a request to correct some of the typographical errors on the labeling and the identified 

letters were circled on the EPA approval. We could find no problem with the some of the 

words circled ex: adsorbed and body page MO under (PPE) requirements so no changes 

~'\'ere made. The other minor modifications requested have been incorpora ted in the 

appended labeL 

If you have any questions plense feel free to contact me . 

Sincerely, 

&! ~;t .JPu--"';' 

Wnrrcn A. Davis 

Senior Registr<1tion Manager 

;:\J eox 12014 :? 1 "V hEXAND~R op,>" R~SEAROi iHiANGLE Pl·RK f; C :>!;,n 

fSI9J 5·19 2000 

I/JT(RNATiONA!.. ,(LEX NUVSER 49Jj37~ AN;V;[ !<BACK /,f-'C f-lU' 

INr,;RNATIONAc DISTRIBUTiON SPRV"~ES liLFX t,uum:[1·:9'1'i3!!·· .;Ns\...,rR"J;.Cc. M C '1:3 

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fxcellcncc In Performance 

Pr,de if) Achleh~mel1{ 

79 
PREpTM 4 PLANT REGULATOR FOR COTTON 

FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. 

NOT FOR RESIDENTIAL USE. 

ACTIVE INGREDIENT: 

Elhephon I(2-chloroelhyl) phosphonic aCid]- ........................................................................................... 39.9% 

INERT INGREDIENTS: ......................................................................................................................... 60.1% 

'This product conlains 4 pounds elhephon per galion. 

EPA Reg. No. 264-380 EPA Est. No. 264-PA-01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

51 usted no entiendo la otiquota, busquo a alguren para quo so la explique a ustoo on delallo. 

(H you do not undorstand tho labor. lind somoono to explain it to you in detail.) 

For MEDICAL And TRANSPORTATION Emergencies ONLY Call 24 Hours A Day 1-800·334-7577 

For peOOUCT.lJ..S..E. Information Call 1-80()'334·9745 

•

he use of this product for a variety of plant growth regulation uses is covored by Unitad States and foreign patents inclUding 

.5. Patonts 3,879,188 and 4,240,819. No liconso is granted to use this product in countries oth9r than the United States or for any 

use not contemplated by this label. liability for patent infringement may rosult from use or sale 01 this product outside 1he United 

States. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EVES: Hold eyelids open and flush with a stoady, 90nllo stream of water for at least 15 minutos, GET MEDICAL ATIENTION, 

PREFERABLY AN OPHTHALMOLOGIST, 

IF ON SKIN: Immediatoly wash with plenty of soap and water, 

IF SWALLOWED: Do not induce vomlting. Promptly drink a largo quanlity of milk, egg whiles, golatin solution or if theso are not 

available, drink largo quantities of water. Avoid alcohol. Call a physician immediatoly. 

IF INHALED: Remove victim to frosh air. If not breathing, give artilicial respiration. Administer oxygon if nocessary. GET MEDICAL 

ATIENTION. 

NOTE TO PHYSICIAN 

eNO specific antidote is available. All treatments should be based on obsorved signs and symptoms of distross in tho patient. 

Overoxposuro to materials other than this product may have occurrod. 

Victims 01 severo overexposuro, by inhalation, should be kept undor modical observation lor up to 72 hours for dolayod onsot 01 

pulmonary odema. In a victim of overexposure by ingestion. careful gastric lavage is roquired due to the possibility of stomach or 

esophagoal perforation. This material is an acid, but tho use of alka6no SUbstances to noutralizo it is contraindicated. 

PRECAUTIONARY STATEMENTS 

Corrosive. Causes eye damage and skin irritalion. Do nol get in eyes, on skin, or on clolhing. • ••••• •••• • • • • • • • • 

Harmful or fatal if swallowed. Avoid contamination of food. •• • • ••••• • • • •• 

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·NOTE TO PHYSICIAN 

No specltic antidote is available. All treatments should be based on observed signs and symptoms of dislress in the 

patient. Overexposure to materials other than this product may have occurred. 

Victims of severe overexposure, by inhalation, should be kept under medical observation for up to 72 hours for delayed 

onset ot pulmonary edema. In a victim of overexposure by ingestion, careful gastric lavage is required due to the 

possibH~y of stomach or esophogeal perforation. This material is an acid, but the use of alkaline substances to neutralize it 

is contraindicated. 

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and olher handlers must wear long-sloeved shirt and long pants, watorproot gloves, shoes plus socks and protectiva 

eyewear. 

When handlers usa closed systems, enclosed cabs, or aircraft in a manner that meets the roquiremants listed in the Worker Protection 

Siandard (WPS) for agricultural pesticides [40 CFR t70.240 (d) {4-6)J, the handler PPE requirements may be reduced or modified as 

speciliod in tha WPS. 

Discard clolhing and othor absorbont matorials that have boen drenched or heavily contaminated w~h this product's concentrate. 00 

not reuso them. Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables, use detergent 

and hot water. Keep and wash PPE separately from other laundry, 

should wash hands belore eating, drinking. chewing gum, using tobacco or using the toilol. 

I I 

ENVIRONMENTAL HAZARDS 

Avoid spray drift to noarby crops as this product may cause temporal'{ modifications in plant growth. Do not contaminato water used 

for irrigation or domostic pUrp05as. 

For terrestrial uses, do not apply directly to watar, or to areas where surfaco water is prosent or to intertidal areas below the moan high 

water mark. 00 not contaminate water when disposing ot equipment washwaters. 

Do not excood the rata of PREPnoi per acre per year recommended on this label. 

DIRECTIONS FOR USE 

It 18 8 violation of Federal law to use this product In a manner Inconsistent with Its labeling. 

Read entlr. label before usIng thIs product. _Do not apply this product In a way that will conta.ct workers or other persons, e~her directly or through drift. Only protected handlers 

may be in the aree during application. For any requirements specific to your State or Tribe. consult the agency responsible for 

pesticide regulations. 

AGRICUL I URAL USE REQUIREMENTS 

Use this product only in accordance with Its labeling and with the Worker Protection Standard. 40 CFR part 170. This standard contains 

requiremants for the protection of agricultural workers on tarms, forests, nurseries. and greenhouses, and handlers 01 agricultural 

pesticides. It contains requiremenls for training. decontamination. notification, and emergency assistance. It also contains imU<; 

instructions and exceptions pertaining to the statements on this label about personal protective equipment {~~ llotilicftiort tez 

workers and restricted-entry interval. The requirements In this box only apply to uses of this product that are covel'Od ~y the ytot1<fr 

Protection Standard. • • •• Do not enter or allow worker entl'{ into treated areas during the restricted-ontry interval (REI) of 48 hours. • •••• 

PPE required lor early entry to treated areas thai is permitted under the Worker Protection Standard and that inf~lvls conlMl.:With 

anything that has been treated such as plants. soil or water is coveralls, waterproof gloves, shoes plus socks and'P.rotOOlive eyewoar. -" ... Notiw workers of the application by WaminQ them orally and posting warninq siQns at entrances to treated areas. •• • •• 

. .. •• • •••• 

GENERAL INFORMATION .... 

'" .. . • .. • 

A foliar spray of PREpm 4 Plant Regutatorwill accelerate opening ot mature unopened cotton bolls andm-rance 

defoliation which can result in earlier harvest with an increased recoverable yield. PREPTM 4 Plant Regutator treatment 

allows increased efficiency from a once-over harvest. 

81 
·Some premature drop ot small, immature bolls may be associated with treatment. Do not apply betore sufficient, mature, 

unopened bolls have developed to produce the desired yield of coUon. 

A boll is mature when it is too hard to be dented when squeezed between thumb and lingers. too hard to be sliced with a 

sharp knite, and when the seed coat becomes light brown in color. 

For best results, thorough and uniform spray coverage is required. It is essential that the bolls are contacted by the spray 

to obtain optimum boll opening. Observe treated fields closely. Harvest at optimun boll opening and defOliation, generally 

14 to 21 days after treatment. Sustained cold weather with average day and night temperatures of 65°F or lower after 

treatment wilh PREf'TM 4 Plant Regulator will delay the boll opening response. 

DO NOT APPLY PREprn 4 PLANT REGULATOR IF RAIN IS EXPECTED WITHIN 6 TO B HOURS. 

Rainfall within 6 to 8 hours of application may reduce producl performance. 

Certified cotton seed growers should observe boll and seed maturity betore treatment with PREpTM 4 Plant Regulator. 

Bolls not completely mature m'lght open with treatment at PREpnt 4 Plant Regulator giving lower quaflty seed. 

Spray deposits of PREpm 4 Plant Regutator, when left on aircraft acrylic plastic type windshields tor longer than 1 hour, 

may react with this material, forming an opaque film or spots on the surface which cannot be removed by washing with 

water or any other cleaner. Rinse windshields with water immediately after each tankload of PREpnt 4 Plant Regulator has 

.een applied. Thoroughly rinse the aircraft with clean water alter each day PREpTM 4 Plant Regulator is applied. 

PREpn.t 4 Plant Regulator may also aUeci certain paints, and if accidental deposits on painted objects such as cars, trucks, 

agriculturaf equipment, etc. occurs, these objects should be rinsed with water as soon as possibte (within 1 hour) to 

prevent permanent staining of the painted surface. 

SPRAY PREPARATION 

Add 1/2 to 3/4 of the required amount at water to the spray tank. Start agitation. Add the required amount of PREpt'M 4 

Plant Regulator. and the remaining amount ot water. Prepare only as much spray solution as can be used on Ihe day of 

mixing. Do not allow spray solution to stand overnight. 

Do not spill the concentrated product on spray equipment. or any airplane parts. ANY SPILLS SHOULD BE RINSED 

IMMEDIATELY WITH PLENTY OF WATER. 

Use of a nurse tank is highly recommended tor avoiding possible spillS at concentrated tormulation on spray equipment or 

any airplane parts. 

EQUIPMENT CLEANING _ Because at the acidic nature ot this product, prolonged exposure to spray deposit will damage acrylic plastics, certain 

paints, and metals. 

Rinse thoroughly with a detergent and water all exposed acrylic plastic-type materials (e.g., aircralt windshields), and 

painted surtaces wijhjn an hour atter exposure to spray deposits. AI the end of each day. rinse thoroughly with a 

detergent and water all the metat parts 01 the aircraft and the associated spray equipment exposed to the spray deposits . 

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82 
aOLL OeE~I~G 

Rates For Boll Opening 

CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 

5·7 DAYS AFTER PREP"'4 OF PREP'" 4 GAl.lACBE 

TREATMENT OUARTS/ACRE TREATS GROUND AIR 

Hot and dry aO"F or higher 1.0 (1.0 Ib a.i.) 4 Acres 151050 2 to 5-

Dry with temperature 1.5 (l.Slb aj.) 2.5 Acres 15 to 50 2 to 5-

7S"Flo 80"F 

Cool but higher than 65'F 2.0 (2.0 Ib aJ) 2 Acres 15 to 50 2 to S" 

Rank cotton 2.0 (2.0 Ib a.i.) 2 Acres 25 to 50 5 

·NOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications 

Time of Application (Boll Opening) 

MPPly when there are sufficient mature unopened bolls to produce the desired yield. but no later than when 60% of the 

8011s are opened (see Generallnforrnation section on how to test for boll maturity). Do not lank mix PREPT'loI 4 Planl 

Regulator with a desiccant if the cotton is to be spindle harvested. 

PRECONDITIONING FOB DEfOLIATION 

Bates For preconditioning For DefOliatioD 

CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 

5·7 DAYS AFTER PREPl'M 4 OF PREP'" 4 GAL.IACRE 

TREATMENT OUARTs/ACRE TREATS GROUND AIR 

Hot and dry 80'F or higher 0.5 (O.S Ib a.i.) a Acres 15to SO 2 to S· 

Cool but higher than 65"and 1.0 (1.0 Ib aj.) 4 Acres 1S to 50 2 to S· 

also for rank cotton 

_·NOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applicalions. 

Time of Application (preconditioning) 

Apply PREprn 4 to 7 days prior to application of deloliant or tank mixed with the defoliant (see section on Compatibility). 

Do not tank mix PREpTM 4 wllh desiccants unless plant desiccation is required. 

pre~treatment With Defoliants prior to PREpTM 4 plant Regulator Treatment 

If Ihe cotton is overly rank or laying down in the middles and good spray coverage of the bolls with PREPfU 4 Plant •••••• 

Regulator is difficult, a prelreatment with defoliants will be useful to improve boll coverage with PREprM 4 'PI~flL Regtliat!fr. : 

Use dosage rales of PREpTloi 4 Plant Regulator recommended for boll opening. Read and observe all apt)foprfate labe' ••• 

use directions and precautions for the defoliant used. • •••• 

• •••• 

Do not use a delolianl before there are sulfic/ent mature unopened bolls to produce the desired yield (see General •• : •• • 

Informalion section on how th test for BoU Maturity). • •• •• • • 

••• • ••••• 

COMPATIBILITY • • ••• 

PREpTM 4 Plant Regulator is compatible with DEF, FOLEX, DROPP, HARVADE, METHYL PARATHION,:~tHION ANJ> •• 

MALATHION. and may be applied in sequence or as a lank m~tur. (DO NOT TANK MIX WITH DEFOLlANT~QR ..... 

DESICCANTS IN CALIFORNIA AND ARIZONA). In some cases slight reduction in boll opening respon!iftN-s been 

observed when tank mixes with defolianls were used. 

83 
'Good agitation in the spray tank is essentiat and a tank mixture should not be allowed to stand without agitation for more 

than 5 to 10 minutes. Read and observe aU appropriate label use directions and precautions for the defoliants and 

insecticides used, 

PRECAUTION: DO NOT TANK MIX PREP'" 4 PLANT REGULATOR WITH DEFOLIANTS CONTAINING SODIUM 

CHLORATE BECAUSE THIS RESULTS IN TIHE FORMATION OF HYPOCHLOROUS ACIDS WHICH UPON HEATING 

EMIT TOXIC CHLORINE FUMES. 

WHEN TO HARVEST: Do not harvest cotton sooner than 7 days after a treatment wilh PREprn 4 Plant Regulator, 

Observe the treated crop and harvest when optimum boll opening has been reached. Too early harvest might reduce the 

fun advantage of the treatment and too late a harvest may result in reduced quality and loss of lint which will drop from the 

plant. 

USE PRECAUTIONS 

Avoid spray drift to nearby crops as this product will cause modifications in plant growth. Plant injury or reduced yields will 

result. 

Do not plant another crop within 30 days after treatment. 

Mix only the amount of spray you expect to use each day. Do not allow mixed sotution to stand overnight. 

STORAGE AND DISPOSAL 

~ not contaminate water, food, or feed by storage or disposal. 

:t~.1.'7IUt DISPOSAL I ~:;~~I~I~::.wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of I~ If these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or 

Environmental Control Agency or the Hazardous Waste representative at the nearest EPA Regional Olfice for guidance. 

CONTAINER DISPOSAL 

Triple rinse (or equivalent) the empty containers. Then offer for recycling or reconditioning, or puncture and dispose of in I ~=k~a" landfill. or by incineration or if allowed by state and local authorities, by burning. If container is bumed, stay out of 

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LIMITED WARRANTY AND DISCLAIMER 

The manufaclurer warrants (a) that this product conforms to the chemical description on the label; (b) that this product is 

reasonably fit for the purposes set forth in the directions tor use when it is used in accordance with such directions; and (c) 

that the directions, warning and other statemenls on this labet are based upon responsible experts' evalualion of 

reasonable tests of effectiveness, of toxicity to laboratory animals and to plants, and of residues on food crops and upon 

reports of field experience. Tests have not been made on all varieties or in all states or under all conditions. THE 

MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE 

TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL 

IMPLIED WARRANTIES OF MERCHANTAEILITY OR FITNESS FOR A PARTICULAR PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL 

LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT 

WITH THE LABEL DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL 

CLAIMS, LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, 

WHETHER OR NOT BASED IN CONTRACT, NEGLIGENCE, STRICT L1AEILITY IN TORT OR OTHERWISE SHALL BE 

LIMITED, AT THE MANUFACTURER'S OPTION, TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE 

_RICE FOR, THE QUANTITY OF PRODUCT WITH RESPECT TO WHICH DAMAGES ARE CLAIMED. IN NO EVENT 

_HALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR CONSEQUENTIAL DAMAGES 

RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT . 

• 

RhOna·Poulonc Ag Company 

P,O. &x 12014, 2 T.W. Aloxander DriVe 

Research Trianglo Park. North Carolina 27709 

PREP is a trademark of RHONE-POULENC. 

PREP'"" 4 Planl Regulator for Colton (MASTER) Notification 4/14194, Approved 5/31/94. 

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

Warren A. Davis 

RHONE-POULENC AG COMPANY 

P. O. Box 12014 

Research Triangle Park, NC 27709 

,·1.-',( 3 J 1594 

OFFICE Of 

PREVENTION, PESTICIDES AND 

TOXIC SUSSTANCES 

SUbject: Label Amendment Submission of 04/18/94 in Response to PR Notice 93-7 

EPA Reg. No. 264-380 

PREP PLANT REGULATOR FOR COTTON 

Dear Registrant: 

The labeling ciled above and submitted in connection with registration under the Federal 

Insecticide, Fungicide. and Rodenticide Act (FIFRA). as amended, is accepted subject JO the 

comments reflected on the enclosed sheet. A copy of your proposed labeling stamped 

"ACCEPTED WITH COMMENTS" is enclosed. 

WHAT THIS ACCEPTANCE MEANS: 

Based on your certification, the Agency has accepted the labeling changes Ihat are 

necessary 10 comply with the Worker Protection Standard (WPS) labeling requirements of 40 

CFR part l56, subpart K, described in PR Notices 93-7 and 93-11. Any other labeling changes 

submitted in cOIUlection with this amendment application but not directly related to compliance 

with the WPS have ltot been reviewed or accepted by the Agency. I f you wish to make such 

changes, you must submit a separate amendment application proposing them. If your produci 

is currently suspended, the acceptance of this labeling amendment does not affect Ihe suspension 

in any way. 

WHAT YOU NEED TO DO NEXT: 

By (he next label printing make all the specified changes to your labeling. Send to EPA 

one (I) copy of the final printed labeling: 

• BEFORE selling or distributing any product bearing (he final printed labeling 

AND 

• WITHIN one year from date of Ihis acceptance, 
• 

• 

Page 2 

SUblll1l [he (inal primed labeling Via [he U.S. Postal Service 10: 

Document Processing Desk (FI N~LABEl) 

Office of Peslicide Programs (7505C) 

U.S. Environmental Protection Agency 

·101 M Street. SW 

Washington. D.C. 10460·0001 

Hand or courier deliveries of final primed labeling may be made 10: 

An3chmem 

Document Processing Desk (FtN~LABEL) 

Office of Pesticide Programs 

Room 16M. Crystal Mall 2 

1911 Jefferson Davis Highway 

Arlington. VA 21102 

\~incer/\ 

/ . \ 

',-,/~, ~ /t~<·-

Jim pkin Deputy Chief 

R~gistration upport Branch 

Registration Division (7505W) 

./ 

87 
~---~~~~~-

PREpTM 4. PLANT REGULATOR FOR COTTON 

FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. 

NOT FOR RESIDENTIAL USE. 

ACTIVE INGREDIENT: 

Ethephon [(2-chloroethyt) phosphonic acid]* ............................... ".,." .......................... " ......................... 39.9% 

INERT INGREDIENTS: ......................................................................................................................... 60.1 % 

*This product contains 4 pounds ethephon per gallon. 

EPA Reg. No. 264·380 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

SI usled no entiende ta etiquela, busque a algulen para que sa la expnque a usled en detalle. 

(If you do nol understand the label, find someone to explain it to you in delail.) 

FOr1~J:Aii<i:ffiA 

use of this product for a variety of plant growth regulation uses is covered by Uniled States and foreign patents Including 

Patents 3,879,188 and 4,240,819. No license is granted to use this product in countries other than the United Slates or for any 

use not contemplated by thIs label. Liability for patent Infringement may result from use or sale of this product outside the United 

States. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyelids open and flush with a steady, genlle stream of water for at least t5 minutes. GET MEDICAL ATTENTION, 

PREFERABLY AN OPHTHALMOLOGIST. 

IF ON SKIN: ImmedIately wash with plenty of soap and water. 

tF SWALLOWED; 00 not induce vomiting. Prompily drink a large quantity of milk, egg whites, gelatin sotution or ilthese are not 

available, drink large quantities of water. Avoid alcohol. Call a physician immediately. 

tF INHALED: Remove victim to fresh air. If not breathing, give artificlaf respiration. Administer oxygen if necessary. GET MEDICAL 

ATTENTION. 

_JeTE TO PHYSICfAN 

No specific antidote is availabte. Alt treatments should be based on observed signs and symptoms of distress in the patient. 

Overexposure to materials other than this product may have occurred. 

Victims of severe overexposure, by tnhatation, shOutd be kept under medicat observation for up to 72 hours for delayed onset of 

pulmonary edema. tn a victIm of overexposure by ingostion, careful gastric lavage is required due to fhe possibility of stomach or 

esophageal perforation. This material is an acid, but the use of atkaline substances to neutralize it is contraindicated. 

PRECAUTIONARY STATEMENTS 

Corrosive. Causes eye damage and skin irritation. Do not get in eyes, on skin, or on clothing. 

Harmful or fatal if swallowed. Avoid conlamination of food. 

ACCEPTED 

wilh COMMENTS 

In tPA {..,ll .. r nalt"t 

\j/\Y J ! i:>:H 

HUller Ihc }'m!eral tMe<:tidd6o, 

Fu ... lidM, lind Hoocnlirlde Ad ,,~ .u"~nd .. d. rur Inc pealielde 

r.·."i.'kr",1 wlltc;r tWA Rfi' Nu . 

. 07£-I,:-.Jo 

88 
NOTE TO PHYSICIAN 

No specific antidote is available. All treatments should be based on observed signs and symptoms of distress in the 

patient. Overexposure to materials other than this product may have occurred. 

Victims of severe overexposure. by inhalation, should be kept under medical observation for up to 72 hours for delayed 

onset of pulmonary edema. In a victim 01 overexposure by ingestion, careful gastric lavage is required due to the 

possibility of stomach or esophogeat perforation. This material is an acid, but the use of alkaline substances to neutralize it 

is contraindicated. 

PERSONAL PROTECTIVE EQUIPMENT ~PPE) 

Applicators and other handlers must We~IOng.sreeved shlfJand long pants, waterproof gloves, Shoes plus socks and protective 

eyewear. 

When handlers use closed systems, enclosed cabs, or aircraft In a manner that meets the requirements listed in the Worker Protection 

Standard (WPS) for agricultural pesticides {40 CFR 170.240 (d) (4-6)J, the handler PPE requirements may be reduced or mcxflfied as 

specified in the WPS. t 

Discard clothing and other abso e~ materials that have been drenched or heavily contaminated with this produci10ncentrate. 00 

not reuse them. Follow manufac urer's Instructions for cleaningJmaintaining PPE. If no such Instructions tor washal51es. use detergent 

and hot water. Keep and wash PPE separately from other laundry . 

• r---------~==~=n=======_--------__, User Safety Recommendations 

Users Shoul~wash hands betore eating, drinking, chewing gum, using tobacco or using the toilet. 

Remove clothing Immediately if pesticide gets inside. Then waS(b~~~ ~hOrOUghlY and put on clean clothing. 

ENVIRONMENTAL HAZARDS 

Avoid spray drift to nearby crops as this product may cause temporary modifications in plant growth. Do not contaminate water used 

for Irrigation or domestic purposes. 

For terrestrial uses, do not apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high 

water mark. Do not contaminate water when disposing of equipment washwaters. 

Do not exceed the rate of PREP"" per acre per year recommended on this tabel. 

DIRECTIONS FOR USE 

It fs a vtotation of Federat Law to use thts product In a manner Inconsfstent with Its tabellng. 

__ Read enUre label before usfng this product. 

Do not apply this product in a way that will contact workers or other persons, either directly or through drifl. Only protected handlers 

may be in the area during application. For any requirements specific to your State or Tribe, consult the agency responsible for 

pesticide regulations. 

AGRICULTURAL USE REQUIREMENTS 

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR part t70. This standard contains 

requirements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural 

pestlcfdes. II contains requirements for training, decontamination, notification, and emergency assistance. It also contains specific 

instructions and exceptions pertainjng to the statements on this label about personal protective eqUipment (PPE), nolification to 

workers and restricted-entry Interv~sl The requirements In this box only apply to uses of this product that are covered by the Worker 

Protection Standard. v 

Do not enter or allow worker entry into treated areas during the restricted-entry intervat (REI) of 48 hours. 

PPE required tor early entry to treated areas that is permil~?p under the Worker Protection Standard and that Involves contact with 

anything that has been treated such as plants, soil or water e}::overalls, waterproof gloves, shoes plus socks and protective eyewear. 

Notify workers of the application by warning them orally and posting warning siQns at entrances to treated areas. 

GENERAL INFORMATION 

A foliar spray of PREpnt 4 Ptant Regulator will accelerate opening of mature unopened cotton bolts and enhance 

defoliation which can result in earfier harvest with an rncreased recoverable yiefd. PREpn.14 Plant Regulator treatment 

allows Increased efficiency from a once-over harvest. 

89 
Some premature drop of small, immature bolls may be associated with treatment. Do not apply before sufticient, mature, 

unopened bolls have developed to produce the desired yield of cotton. 

A boll is mature when it is too hard to be dented when squeezed between thumb and fingers, too hard to be sliced with a 

sharp knife, and when the seed coat becomes light brown in color. 

For best results, thorough and uniform spray coverage is required. II is essential that the bolls are contacted by the spray 

to obtain optimum boll opening. Observe treated fields closely. Harvest at oplimun boll opening and defoliation, generally 

14 to 21 days after treatment. Sustained cold weather with average day and night temperatures of 65°F or lower after 

treatment with PREpn.! 4 Plant Regulator will delay the boll opening response. 

DO NOT APPLY PRE!=' 4 PLANT REGULATOR IF RAIN IS EXPECTED WITHIN 6 TO 8 HOURS. 

Rainfall within 6 to 8 hours of application may reduce product performance. 

Certified cotton seed growers should observe boll and seed maturity before treatment with PREpTM 4 Plant Regulator. 

Bolls not completely mature might open with treatment of PREP'fM 4 Plant Regulator giving lower quality seed. 

Spray deposits of PREpt'M 4 Plant Regulator, when left on aircraft acrylic plastic type windshields for longer than 1 hour, 

may react with this material, forming an Opaque film or spots on the surface which cannot be removed by washing with 

.rmter or any other cleaner. Rinse windshields with water immediately after each tank load of PREPTM 4 Plant Regulator has 

.,een appUed. Thoroughly rinse the aircraft with clean water after each day PREpn.! 4 Plant Regulator is appned. 

PREPTM 4 Plant Regulator may also affect certain paints, and if accidental deposits on painted objects such as cars, trucks, 

agrtcultural equipment, etc. occurs, these objects should be rinsed with water as soon as possible (within 1 hour) to 

prevent permanent staining of the painted surface. 

SPRAY PREPARATION 

Add 1/2 to 3/4 of the requJred amount of water to the spray tank. Start agitation. Add the required amount of PREpTM 4 

Plant Regulator, and the remaining amount of water. Prepare only as much spray solution as can be used on the day of 

mixing. 00 not allow spray solution to stand ovemight. 

Do not spill the concentrated product on spray equipment, or any airplane parts. ANY SPILLS SHOULD BE RINSED 

IMMEDIATELY WITH PLENTY OF WATER. 

Use of a nurse tank is highly recommended for avoiding possible spills of concentrated formulation on spray equipment or 

any airplane parts. 

4IIillUIPMENT CLEANING 

ecause of the acidic nature of this product, prolonged exposure to spray deposit will damage acrylic plastics, certain 

paints, and metals. 

RinSe thOroughly with a detergent and water all exposed acrylic plastic-type materials (e.g" aircraft windshields), and 

painted surfaces within an hour after exposure to spray deposits. At the end of each day, rinse thoroughly with a 

detergent and water all the metal parts of the aircraft and the associated spray equipment exposed to the spray deposits. 

90 
IlQLL QeENING 

Rates For Boll Opening 

CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 

S-7 DAYS AFTER PREpTM 4 OF PREP'" 4 GAL.IACRE 

TREATMENT QUARTS/ACRE TREATS GROUND AIR 

Hot and dry eO"F or higher 1.0 (1.0 Ib aJ.) 4 Acres 15 to 50 2 to S" 

Dry w~h temperature 1.S (1.Slb aJ.) 2.5 Acres 15 to 50 2 to 5-

7S"Fto OO"F 

Cool but higher than 6S"F 2.0 (2.0 Ib aJ.) 2 Acres 15 to 50 2 to 5-

Rank cotton 2.0 (2.0 Ib aJ.) 2 Acres 25 to 50 S 

-NOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications 

.fme of Application (Boll Opening) 

pply when there are suffiCient mature unopened bolls to produce the deSired Yield, but no later than when 60% of the 

bolls are opened (see General Information section on how to test for boll maturity). Do not tank mix PREPlM 4 Plant 

Regulator with a desiccant if the cotton is to be spindle harvested. 

PRECQNDITIQNING EQR DEEQLIATIQN 

Rates For Preconditioning For Defoliation 

CONDITIONS EXPECTED 

S-7 DAYS AFTER 

TREATMENT 

Hot and dry BO'F or higher 

PREpTM 4 

QUARTS/ACRE 

ONE GALLON 

OF PREP'" 4 

TREATS 

8 Acres 

SPRAY VOLUME 

GAL.IACRE 

GROUND AIR 

15 to 50 2 to 5* 

Cool but higher than 65'and 1.0 V.O Ib aj.) 4 Acres 15 to 50 2 to 5-

also for rank cotton 

-NOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications. 

Time of Application (Preconditioning) 

Apply PAEpt'M 4 to 7 days prior to application of defoliant or tank mixed with the defoliant (see section on Compatibility). 

Do no1 tank mix PAEf'TM 4 with desiccants unless plant desiccation is required, 

Pre~treatment With Defoliants Prior to pREen! 4 Plant Regulator Treatment 

If the coHon Is overly rank or laying down in the middles and good spray coverage of the bolls with PREpTM 4 Plant 

RegUlator is difficult, a pretreatment with defOliants will be uselut to improve boll coverage with PREpThl 4 Plant Regulator. 

Use dosage rates of PREpTM 4 Plant Regulator recommended for boll opening. Read and observe all appropriate label 

use directions and precautions for the defoliant used. 

Do not use a defoliant before there are sufficient mature unopened bolls to produce the desired yield (see General 

Information section on how th test for 8011 Maturity). 

COMPATIBILITY 

PREf»M 4 Plant Regulator is compatible with DEF, FOLEX, DROPP, HARVAOE, METHYL PARATHION, GUTHION AND 

MALATHION, and may be applied in sequence or as a tank mixture (DO NOT TANK MIX WITH DEFOLIANTS OR 

DESICCANTS IN CAUFOANIA AND ARIZONA). In some cases slight reduction in boll opening response has been 

observed when tank mixes with defoliants were used, 

91 
Good agitation in the spraY,tank is essential and a tank mixture should not be allowed to stand without agitation for more 

than 5 to 10 minutes. Read and observe all appropriate label use directions and precautions for the defoliants and 

insectlcides used. 

PRECAUTION: DO NOT TANK MIX PREP'" 4 PLANT REGULATOR WITH DEFOLIANTS CONTAINING SODIUM 

CHLORATE BECAUSE THIS RESULTS IN THE FORMATION OF HYPOCHLOROUS ACIDS WHICH UPON HEATING 

EMIT TOXIC CHLORINE FUMES. 

WHEN TO HARVEST: Do not harvest cotton sooner than 7 days after a treatment with PREpn' 4 Plant Regulator. 

Observe the treated crop and harvest when optimum boll opening has been reached. Too early harvest might reduce the 

full advantage of the treatment and too late a harvest may result in reduced quality and loss of lint which will drop trom the 

plant. 

USE PRECAUTIONS 

Avoid spray drHt to nearby crops as this product will cause modifications in plant growth. Plant injury or reduced yields will 

result. 

Do not plant another crop within 30 days after treatment. 

only the amount of spray you expect to use each day. Do not allow mixed solution to stand overnight. 

STORAGE AND DISPOSAL 

RAGE 

not contaminate water, food, or feed by storage or disposal. 

PESTICIDE DISPOSAL 

Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of 

Ifede, .. law. Uthese wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or 

Environmental Control Agency or the Hazardous Waste representative at the nearest EPA Regional Olfice tor guidance. 

• 

DISPOSAL 

(or equivalent) the empty containers. Then offer for recycling or reconditioning, or puncture and dispose of in 

landfill, or by incineration or if allowed by state and local authorities, by buming. If container is burned, stay out of 

92 
LIMITED WARRANTY AND DISCLAIMER 

The manufacturer warrants (a) that this product conforms to the chemical description on the label; (b) that this product is 

reasonably lit for the purposes set forth in the directions for use when it is used in accordance with such directions; and (c) 

that the directions, warning and other statements on this label ate based upon responsible experts' evaluation of 

reasonable tests of effectiveness, of toxicity to laboratory animals and to plants, and of residues on food crops and upon 

reports of field experience. Tests have not been made on all varieties or in all states or under all conditions. THE 

MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE 

TO MAKE. ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL 

IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR. ANY AND ALL 

LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT 

WITH THE LABEL DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL 

CLAIMS, LOSSES. DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OFTHIS PRODUCT, 

WHETHER OR NOT BASED IN CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR OTHERWISE SHALL BE 

LIMITED, AT THE MANUFACTURER'S OPTION, TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE 

_RICE FOR. THE QUANTITY OF PRODUCT WITH RESPECT TO WHICH DAMAGES ARE CLAIMED. IN NO EVENT 

~HALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR CONSEQUENTIAL DAMAGES 

RESULTING FROM THE USE OR HANDLING OFTHIS PRODUCT . 

• 

Ahone·Pourenc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, Norlh Caronna 2n09 

PREP Is a trademark 01 RHONE-POULENC. 

PREprn 4 Plant Regulator for Cotton (MASTER) Notification 4114194. 

93 
(,1' 

~ 

RHONE-POULENC , "2" , 

RHCNE,POULENC AG COMPANY 

April 18, 1993 

U, 5, EPA: Worker Protection Standard 

c/o NCI Information Systems 

8260 Greensboro Drive, Suite 400 

McLean, V A 22102 

RE: PR-Notice 93-7 

Worker Protection Standard 

Label submissions for: 

• PREP for Cotton EPA Reg No 264-380 

• 

Appended are Worker Protection Labels for PREP brand Ethephon Plant Regulator for 

Cotton. 

To complete our submission we are including: 

1. A completed application for amended registration 

2. A certification statement that indicates fun compliance and references the categories 

of acute toxicity llsed to complete the WPS 

3. Two copies of current labeling market to indicate wording deleted to comply with 

WPS 

4. Five copies of proposed labeling (two highlighted to identify changes) with worker 

protection standard additions highlighted . 

If you have any questions please feel free to contact us promptly. 

Sincerely, 

j 'J j /) ~ 

{;/@['oc ,,0 :t:6t.{f2 

Warren A. Davis 

Senior Registration Manager 

PO BOX 12014 2 TW f<L[XAN0lR C+li\'t 

R1'SEARCH TRIM,GU' PARK .'i C 17Nj\l 

{91\l)54?-20C:0 

11{TtJ1NATION'\~ TELEX NU'AB(R 4929315 ~NSWlRBACK APC G,P 

JNT~RNATtONAl OISTRIBUTiON SERVICES TFl_f~ ,-ur.mE" ~99<)3!7 -"-NSI',EI1GACK APC JiX; 

Exce!fence In Performance 

Pnde Ifi Ac/1levernen! 

94 

1- t 
• 

WORKER PROTECTION STANDARD 

CERTIFICATION STATEMENT 

I certify that the revised labeling being submitted for: 

PREP brand etbepbon Plant Regulator for Cotton 

EPA REG NO. 264-380 

is in complete accordance with the labeling requirements of PR Notice 93-7, which reflects 

the requirements of EPA's labeling regulations for worker protection statements (40 CFR 

part 156, subpart K). Where exact language is specified in the PR Notice, I have used that 

language exactly, in the location specified. I further certify that no revisions are being 

submitted other than those directed by PR Notice 93-7. I understand that it would be a 

violation of RPRA if I or my supplemental registrants were to sell or distribute this product 

after April 21, 1994, without amended labeling complying with the requirements of 40 CFR 

part 156, Subpart K. 

Idj". ,ar diif</'"~ 4/18/94 

Warren A. Davis 

Senior Registration Manager 

The acute toxicity categories (I, II, III, IV) for this product as entered in blocks 3-7 on Part I 

of the Product Worksheet are: 

_3_ Acute oral toxicity 

_3_ Acute dermal toxicity 

_4_ Skin irritation potential 

_1_ Eye irritation potential 

_4_ Acute inhalation toxicity 

95 
. ', . PI, '"' '0 

Unitod Stotes § Registration opp tdontifh" Number 

.oEM Environmental Protection Agency Amendment 

W01lhington, DC 20460 217706 Other 

lIor - I 

1. Compony/Product Number 264-380 l2. EPA Product Mllnogot 13. Proposed CI8uifICotion 

C. G. Parker 

ONono D Rostricted 14. Company/Product (Namo) PM' 

11l"l':IA Plant Regulator 22 

is. Nama and AddrOl'1I of Apptlcont {lncludo ZIP Codo} 6. Expedited Reveiw. In accotdance with FIFRA Section 3{cH3) 

Rh6ne-Poulenc Ag Company (bHil. my product is similar or identical in composition and labeling 

2 T- w_ alexander Drive to: 

p- O .... ~~x~ 12014 EPA Reg. No. 

Triangle Park, NC 27709 

[ ] Chock if this is 8 now address Product Name 

I - II I! Am,odm,"" ,,,',i' b",w. 0 Rnlll print&<! labols in topsonlO to 

Agency lottot dotod 

. RosubmlSllion in rosponse to Agoncy lottor dotod ~ ___ ~~_ 0 ~Mo Too~ Applicotion. 

D Notilication - EXplain bolow. 0 Olher· Explain bolow. 

Use 4dditional plIgols) il ncCOSIIOry. (For soction I and Section It.) 

Amended for Worker Protection Standard. PR Notice 93-7 

-III 

j _ "',du'" lin' 

P$ckoging Unit P$ckoglng Watar Soluble Pock$ging 2. Typo of Container 

BY" ,.. y" ,. y" §iT"· N, f- N, f- Plostic N, Gloss 

must II 'Yas~ No. per If ~Ye\l~ No. per Popor 

be-submlttsd Unit Packaging wgt. contaln(lt Pockllgo wgt container Othor 

I 

3.' Not , 14. Si,,'" Ro'. >o/L,b,' , 

o Lob,1 0 -

6. Monnar in Which Lebol is Alfixoo to Product 

~ o Other 

-IV 

1. Contact Point (Ccmp/flfe items directly below for of individual to btl contacfed, ,thi •• 

Name Tille Talaphone No. Itncludo Atea CodoJ 

Warren A_ Davis Isenior Registration Mgr. 

Certification 6. Dllto Application 

I cortify that tha statements I hovo mOOo on this lorm and ell ottechffientB t~ralO lUO trull, eccurote end complata. Receivod 

I IIcknowledge that any knowlinoily la/so or misleading IItatament may bo punishable by fino or irJ1P!i$o~"'ft or • •• (stamped) • • • 

bothundor I law. :.: :_. • • • • •• 

• • 

: -.- • • 2. Signature 3. ndo • • • 

Senior Registration Manager 

I'" 'ypoo Nume 5. Doto ••• 

• • -'; -:~ Warren A_ Davis April 1 a , 1994 • 

• 

• · .: . ···QR 

, •• 70-1 1,*'.3-941 , , Whh. - EPA Fil. C""y y,'ow· . 
--------------------- --- ._ .. 

AAf~ REDUCTICH AtT mItE: Public ~ina irurdIm 1fU' this roU«:::tfoo t:rf fnfOf".Sll)tioo is estll!l2ttd 

to _ ... 0.85 hoot" per 'up6fUe. including time 101" rmwillG inetruttiCf'ij. H:et¢M~ «misting data :toon;>m:, gathering and 

aaintainil'l9 the data M!.!dcd, and cct!!pteting and tm'icufna ttm- eotles:ticn of hrfonmtion. SCO::I ~t$ reaarding the ~ 

m:;timete Of'" t:.frt other mpect of this coUection of i~tien. inctuding ~tiCl'l$ {Of' nlWI;ing this burden. to Chfef. 

Jnfonmtfen ~i icy 9r-lIiOCh~ f>M·223. I1.S. Envf~t' Protecticn~. 401 It Street_ $IJ~ lJeshi09ton. l'X: 2fi46O; l'!II'Icl to the 

Office of Inf()niEItiOl1 lItld RS9Uillltcry Aftain=:, OffiCI: of MIs Q, ~ and ~t~ Udhineton4 DC 20503. 

lhh: fortA' is to be UU:d for lIU lIflplieatiana fw rev rmei:tratioo. end IRe reregh.tratlon. mendrMnt. 

;--;;C--'icetions for notffieatiCll'lS-. final prfnHd l_ling, reregi$tratioo. etc. in ~ to prOCII$S an 

oppi ication a MIl regfttratien stafttcd 00 thi$ fon:r., the foUowing IIIttet'iai II1USt ~ the appi icatiom 

1. Certification }lith Respect to Citatian at Data (£fA Fcr111851\)...29). [If fIIlt ex_ted by 4tI em 152.81 (b) (4)1; 

2. Confidential Statell'limt of Forwia (EPA For. 8570-4); 

3. Foraltator'$ Exeopticn StatlttW"lt (EPA Fora 8S7U·znf 

4. Fiw copies of draft labeling; 

5. Three capies of any data stbritted; 

6. Authorization lettel' wftere appUefble; 

7. "-trices ~re apptictblo. 

Si.ba:lssico of lnbeilF?l • Labeting =hould firn be $daitted fl'o the fom of draft tabels with at! awlicatlcm. fo; new 

l&bel. 

registration. 

If prepared 

sueh as draft a IlIOCkl.4l, labels fMi'/ 

It should 

be in 

be 

the 

com:tru:ted 

fon!! of typcd 

in sud! 

label • tart 

..., on _ a..s to facilitate 

x 11 fncb pq»r 

stonee 

or 

in 

a..x-h4' 

an 8.5 It 

of 

11 

the 

inch 

~ 

file. 

Kocklp labets significantly .. Her tlun 8.5 x 11 it'\ItIM:I. -should be IiICWthd on 8.5 x 11 ild p:eper for .IIfJbcIisllion. 

$tbBil$ico of Dat-a • nata subuitted in s.upport of this ...,tiarticn rwat he sWaitted in ~ with Pit Notice 36·5, 

SPECIfIC INSTRUCTIONS: Plooee resd the imtructicm lhttl!ld bel"" hefMlt CCII!ptetfne this application. Finn 

determir~ the type of registration action, t lated in Block A# fer whim yw are subafttil'l9 this IIflPllcation. For 

apptiClltioos. st.bnltted in eonnectlon wtth If(!tI ft09i&tratiot'lllllCticm, Seeticnr. l~ Ill, and IV _t be toIiPleted by the 

appl icant. For appllcatioos. IIl.bmlttod in CCl"l'lGCtion 'trith fiIIIi!tlded resbtration actions, .--bDis.sioos., notl tlc;ltiOl'1$, 

Btock 

reregistrations, 

A • Check the 

etc., 

&ppf'cpript\! 

Sectioos. 

action 

I, ii, and 

for Wiich 

IV RUSt 

you 

be 

lIN 

~e«:d 

~ttins 

by tM 

tfIIis 

liIf'Plieam:. 

fctIL 

• 

SECTION I • This llcctiro a.mt be cospleted, .u ~iahlel fer aU NOfstratJon a.t:ti(ll'$. 

1. ~/praiJet IWiI!IOOr • It'l$ert yew' ~~, if OJ'II! bas been .!Ii&IdQmlld by £PA. rhi!i. ~ f!iI'.f'j hllve boon nuf1:jOed 

to you as a basfc r~il>trllllt .. ill dbtribotor. or .. ./IIi1lt$teblf~~ If your ~t is I"t:gistered, 1l'l1.ltrt the Pn:duet 

........ 2. £Ph Produet ~ • If knotm, fill in tM I"IIBIWl 2M PM ~ of the EPA"~~. 

3. I'~ Cl_ifiCQticn • 3plcify the ~ el_tficsdcn of tbh. ~t. 

4. prcd!Jc:t IhI5e • Enter the c{)I'IIf)lete prod.tt:t ~ of this pes:Ueide d it will ~ en the Iil!beL The ~ IWIIt be 

specific to this pt'otruet only. D!4'iieathm. ot rs1iIIU is Mt: pmwttted ~ ~t.s of the HIl!Ie~. IX! not hv;lll!ie 

tnt Iward I"dIe or cOillpMy liM _'snetlons. 

5. =- end ~ of Appticmrt: - The I1MIIe of the tina or peNlOn;and wreu ~ in ~ appHC4ticn is the ptffM or flMl'l 

to whiOS the- registration witt be hs.utd. If 'fO'.J l'WlI! mint in bfttf of ~ pcrty, you lIIWt stbait mrthodviHon frOOl 

that perty tQ m::t fer thea in registration ImtteN. An ¥iQlS'lt not Ni$idil'1liii in ttw Iklitcd Stateti I!'t.Wt haw an' 

rurthorbed agent ru:fding ih the tklited Statu; t\HIt:t 10/(' mm in aU l"tIGi'iitratiQfl i!!l$ttIWZ. TM MIi!:t and ctXip1ett' mil i'09 

&ddress of such MI agent !!!Wt KC~ this apptialticn. 

6. Elq:edftod R~ieu - rUAA !!et:tioo 3 {cl 3 (in provides fot" ~iUrl rmiew of ~iC!iti_ for ~f5ttatioo. ¢f' ~t$ 

to existing registratioos. that are siallar or l'dentia;t bO ~ pe$tiddie pr«bt:t$ that ere arrontty regbtered with 

the EPA. In Proor f(}r YOO.J:" application to be etigibf.e frw ~t<td null5l" you _t pNNidt: Wi wjth the EPA Reabtrbtione 

l\Iut:ber end prcdtict I'WI!liIe of the pr--l'rl.ICt you 1»1 it!W f#- -sf.Hu to rw fdentfut to 'fOUl" ~t. The predx:t !l!!!J$t I» 

si#!iiar or identical in bQth f6hWI&tion and Ibled 1J$d. 

§ECTXOH II - fhis section IlUSt I» completed fPr aU applfcati_ ~t:t.ed to ~ ttw ~btratioo oo!y of a ClJil'"rently 

registc-rW pnxIut;:t ~t). for & l"~iMion in ~ til' an ~ lort1:cf', (Of" MtificatiOf:l!l to the MoocY# Ita" tl'l¢ 

submJsslon of fiMI pi"lnted tabet inq, for reregistr'8tion and fur II!rtf otlw:r ktion _t pertaln& to G !JW:!ffiiffc m·mh;tsr%! 

~. This section IS!l2!12 2! wed for. ow gpplie.tion 1« reait;traticn... 

1. SUbject of 5tlbaissilln • CMt.k the applicable block end pNWid!ll the Aeenqr letter date if ~i.te. I'nwim tI brfef 

expll\ll1lfltflln of the ptIif'POU{$) for the $4mihilln, weft as "'the NAff1:icn of 111 site-" pest (If' crop (specify)"; I<aaet')d the 

Confidential Stateeent of fomuta by ••• I<; ·~Istraticn tMariniGl"l'; ~l lab« ntNisi'cn of lIM directior;s." Attoch 

a St!pM'ate pep If additional spaoe is needed. 

,sECTION III (Packaging and Container Infonptiool - This kctit:n _t be ~eted for all IIflPllcatiooo 

subilltted In ecmectfon with nw reelst,-.tion or lflPlicehl .... ' lb. 

1. Type of l'ac:k.l!Gine· Che<:k tM ~Iate block if Y'M' product trill be I ........ in. indicated pod:.aging types. 

h-dicate the size of tJa. Indl'liul pocltets .u nwber per ntaf( eaufftlB". 

2. Typo of .... n tcntaintw • indie.t~ t)'pe of cantainw in tAidt prdIt;t win .. ~. 

3. lceaticn of IIet Contents - Specify the net ~ of aU f'VltlIil eont.inma fc¢- your" pn:x:b;:t. 

4. Si •• ) of Retaf( OIIntainer - $p$eify the net contenta of aU retail Containers -fur )'11M"' pnldJct. 

5. t.oclrtlcn of UIe Dlrectiona • Irdlcate the lotaticn of tbe we direetiORC for your pnxIct. 

6. IIW!ncr inotAidtot ... f. _Hhwd _ JIII"OIfutt • Indicate tM ~ prdId: lebd ia Iltt1diled 'to ru..il erotalMl". "io • •• •• 

... ... .. " .. S~ ry (t~Ct POintl ~ This section ... t be c:apteted for .U apptfc:etiGnlll: for Registration actlcnr., i.e., 

new ts r*lis Mlti&n, rHlJ.:aihion, ___ too,1< rereaiatratfrn.. etc. 

1·5. S.lf·expt_tory. 

6. EPA OM Only. 

•••• •• • • •• • •• • •• •• • ••• ... · .. .. "" , 

97 
• 

• 

PREpTM 4 'PLANT REGULATOR FOR COTTON 

FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. 

NOT FOR RESIDENTIAL USE. 

ACTIVE INGREDIENT: 

Ethephon [(2-Chloroethyl) phosphonic aeid[" 39.9% 

INERT INGREDIENTS: .......................•............................... 60.1 % 

"ThIs product contains 4 pounds elhephon per gallon. 

EPA Reg. No. 264-380 EPA Est. No. 264--PA-01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUCION AL USUARIO;-SI listed no 199 ingles, nQ 1.1GB E1ste prodYGtO-hasta-que-ta4mom:taGi~a 

etiquela Ie haya siOO-&xpliGado-ampiiameRt9, 

+RANSLA+ION-W-T.HE-US£R:-lt-yoU--Gannot.+eaQ...€RglisR-dQ-OOt-USe-this-produGt-umi\..Ute.-labal-has.Ge9R 

1u~/aiooQ.jQ.l'OU. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EVES: Hold eye/ids open and flush with a steady, gentle stream of water for at least 15 minutes. GET 

MEDICAL ATTENTION, PREFERABLY AN OPHTHALMOLOGIST. 

FOR ADDITIONAL PRECAUTIONARY STATEMENTS: See Inside Label 

For PRODUCT.!.!..S..E /nformalion Call 1-800-334-9745 

For EMERGENCY Information QNlY Ca/124 Hours A Day 1-800-334-7577 

The use 01 this product for a variety of plant growth regulation uses Is covered by United Slales and foreign patents Including 

U.S. Patents 3,879,188 and 4,240,8t9. No license is granted to use this product In countries other than the United States or 

for any use not contempla!ed by this label. Uabilily for patent infringement may result from use or sale of this product outside 

the United States. 

Ahone-Poulenc Ag Company 

Posl Office Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, North Carolina 27709 

PREP is a frademark of Ahone-Poulenc. MADE IN U.S.A. 

98 
PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

Corrosive. Causes eye damage and skin irritation. Do not get in eyes, on skin, or on clothing. W-ea~Qles-or 

faGe-SRield and rubbQ~QlI&s when haRdling. 

Harmful or fatal if swallowed. Avoid contamination 01 food, 

STATEMENT OF PRACTICAL TREATMENT 

IF ON SKIN: Immediately wash with plenty of soap and water. Remave-oontamiflateEi-e1ethifl§-ElflHhoes.-Wash 

clothing separately-befme-r{HJ5e; 

IF SWALLOWED: Do not induce vomiting. Promptly drink a large quantity of milk, egg whites, gelatin solution 

or if these are not available, drink large quantities of water. Avoid alcohol. Call a physician immediately. 

IF INHALED: Remove victim to fresh air. If not breathing, give artificial respiration. Administer oxygen il e necessary. GET MEDICAL ATTENTION. 

• 

NOTE TO PHYSICIAN 

No specific antidote Is available. All treatments should be based on obselVed signs and symptoms of distress in 

the patient. Overexposure to materials other than this product may have occurred. 

Victims of severe overexposure, by inhalation, should be kept under medical observation for up to 72 hours for 

delayed onset of pulmonary edema. In a victim of overexposure by ingestion, careful gastric lavage is required 

due to the possibitity of stomach or esophogeal perforation. This material is an acid, but the use of alkaline 

substances to neutralize it is contraindicated. 

ENVIRONMENTAL HAZARDS 

Avoid spray drift to nearby crops as this product may cause temporary modifications in plant growth. Do not 

contaminate water used for irrigation or domestic purposes . 

For terrestrial uses, do not apply directly to water, or to areas where surface water is present or to intertidal areas 

below the mean high water mark. Do not contaminate water when disposing of equipment washwaters, 

Do not exceed the rate of PREpThl per acre per year recommended on this label. 

DIRECTIONS FOR USE 

IT IS A VIOLATION OF FEDERAL LAW TO USE THIS PRODUCT IN A MANNER INCONSISTENT WITH ITS 

LABELING. 

GENERAL INFORMATION 

A foliar spray of PREPTM 4 Plant Regulator will accelerate opening of mature unopened cotton bolls and enhance 

defoliation which can result in earlier halVest wilh an increased recoverable yield. PREpnt 4 Plant Regulator 

treatment allows increased efficiency from a once-over harvest. 

Some premature drop of small, immature bolls may be associated with treatment. Do not apply before sUflicient, 

mature, unopened bolls have developed to produce the desired yield of eOlian. 

99 
• 

• 

A bol! is mature when it is too hard to be dented when squeezed between thumb and fingers, too hard to be sliced 

with a sharp knife, and when the seed coat becomes light brown in color. 

For best results. thorough and unifonn spray coverage is required. 11 is essential that the bolls are contacted by 

the spray to obtain optimum bol! opening. Observe treated fields closely. HalVest at optimun bol! opening and 

defoliation, generally 141021 days after treatment. Sustained cold weather with average day and night 

temperatures of 65"F or lower after treatment with PREpTM 4 Plant Regulator will delay the boll opening response. 

DO NOT APPLY PREP'" 4 PLANT REGULATOR IF RAIN IS EXPECTED WITHIN 6 TO 8 HOURS. 

Rainfall within 6 to 8 hours of application may reduce product performance. 

Certified cotton seed growers should observe boll and seed maturity before treatment with PREpnt 4 Plant 

Regulator. Bolls not completely mature might open with treatment of PREprn 4 Plant Regulator giving lower 

quality seed. 

Spray deposits of PREprn 4 Plant Regulator, when left on aircraft acrylic plastic type windshields for longer than 1 

hour, may react wIth this materIal, fonning an opaque film or spots on the surface which cannot be removed by 

washing with water or any other cleaner. Rinse windshields with water immedIately after each tankload of PREflTM 

4 Plant Regulator has been applied. Thoroughly rinse the aircraft with clean water after each day PREpm 4 Plant 

Regulator is applied. 

PREprn 4 Plant Regulator may atso affect certain paints, and if accidental deposits on painted objects such as 

cars, trucks, agricultural equipment, etc. occurs, these objects should be rinsed with water as soon as possIble 

(within 1 hour) to prevent permanent staining of the painted surface. 

SPRAY PREPARATION 

Add 112 to 3/4 of the required amount of water to the spray tank. Start agitation. Add the required amount of 

PREPTM 4 Plant RegUlator, and the remaining amount of water. Prepare only as much spray solution as can be 

used on the day of mixing. Do not allow spray solution to stand ovemight. 

Do not spill the concentrated product on spray equipment, or any airplane parts. ANY SPILLS SHOULD BE 

RINSED IMMEDIATELY WITH PLENTY OF WATER. 

Usa of a nurse tank is highly recommended for avoiding possible spills of concentrated formulation on spray 

equipment or any airplane parts. 

EQUIPMENT CLEANING 

Because of the acidic nature of this product, prolonged exposure to spray deposit will damage acryUc plastiCS, 

certain paints, and metals. 

Rinse thoroughly with a detergent and water aU exposed acrylic plastic-type materials (e.g., aircraft windshIelds), 

and painted surfaces within an hour after exposure to spray deposits. At the end of each day. rinse thoroughly 

with a detergent and water all the metal parts of the aircraft and the associated spray equipment exposed to the 

spray deposits. 

100 
• 

• 

BOLL OeE~ltlG 

Bates For Boll Opening 

CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 

5·7 DAYS AFTER PREpTM 4 OF PREP'" 4 GALJACBE 

TREATMENT QUARTS/ACRE TREATS GROUND AIR 

Hot and dry aO'F or higher 1.0 (1.0 Iba.f.) 4 Acres 15 to 50 2 to 5· 

Dry with temperature 1.5 (1.5 Iba.i.) 2.5 Acres 15 to 50 2105* 

7S'Fto OO'F 

Cool but higher than 6S'F 2.0 (2.0 Ib a.l.) 2 Acres 15 to 50 2 to 5* 

Rank coHon 2.0 (2.0 Ib a.i.) 2 Acres 25 to 50 5 

*NOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications 

Time of Application (Boll Opening) 

Apply when there are sufficient mature unopened bolls to produce the desired yield, but no later than when 60% 

of the bolls are opened (see Genera! Information section on how to test for boll maturity). Do not tank mix PREPTh1 

4 Plant Regulator with a desiccant if the coHon is to be spindle harvested. 

eBECONDITIONING FOR DEFOLIATION 

Rates FOr preconditioning For Defoliation 

CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 

5-7 DAYS AFTER PREP'" 4 OF PREP'" 4 GALJACRE 

TREATMENT QUARTS/ACRE TREATS GROUND AIR 

Hot and dry eO'F or higher 0.5 (0.5 Ib a.i.) 8 Acres 15 to 50 2 to 5* 

Cool but higher than 65' and 1.0 Q.O Ib aj.) 4 Acres 15 to 50 2t05* 

also for rank colton 

·NOTE: For CaUlomia and Arizona use a volume of no less than 5 gallons per acre for aerial applications. 

Time of Application (Preconditioning) 

Apply PAEpru 4 to 7 days prior to application of defoliant or tank mixed with the defoliant (see section on 

Compatibility). Do not tank mix PREpru 4 with desiccants unless plant desiccation is required. 

Pre·treatment With Defoliants prlQr to PREpru 4 Plant Regulator Treatment 

If the cotton is overly rank or laying down in the middles and good spray coverage of the bolls with PREpTM 4 Plant 

Regulalor Is difficult, a pretreatment with defoliants will be useful to Improve boll coverage wilh PREpn.! 4 Planl 

Regulator, Use dosage rates of PREpn.! 4 Plant Regulator recommended for boll opening. Read and observe aU 

appropriate label use directions and precautions for the deloHant used. 

Do not use a defoliant before Ihere are sufficient mature unopened bolls to produce the desired yield (see 

General Information section on how th test for BoU Maturity). 

COMPATIBILITY 

PREP'" 4 Planl Regulaloris compalible w,h DEF, FOLEX, DROPP, HARVADE, METHYL PARATHION, 

GUTHION AND MALATHION, and may be applied in sequence or as a tank mixture (DO NOT TANK MIX WITH 

101 
• 

• 

DEFOLIANTS OR DESICCANTS IN CALIFORNIA AND ARIZONA). In some cases slight reduction in boll opening 

response has been observed when tank mixes with defOliants were used. 

Good agitation in the spray tank is essential and a tank mixture should not be allowed to stand without agitation for 

more than 5 to 10 minutes. Read and observe all appropriate label use directions and precautions for Ihe 

defoliants and insecticides used. 

PRECAUTION: DO NOT TANK MIX PREP'" 4 PLANT REGULATOR WITH DEFOLIANTS CONTAINING SODIUM 

CHLORATE BECAUSE THIS RESULTS IN THE FORMATION OF HYPOCHLOROUS ACIDS WHICH UPON 

HEATING EMIT TOXIC CHLORINE FUMES. 

WHEN TO HARVEST: Do nol harvest cotton sooner than 7 days after a treatment with PREpnt 4 Plant Regulator. 

Observe the treated crop and harvest when optimum boll opening has been reached. Too early harvest might 

reduce the full advantage of the treatment and too late a harvesl may result In reduced quality and loss of lint which 

will drop from the plant. 

USE PRECAUTIONS 

Avoid spray drift to nearby crops as this product will cause modifications in plant growth. Plant injury or reduced 

yields will result. 

Do not plant another crop within 30 days after treatment. 

Mix only the amount of spray you expect to use each day. Do not allow mixed solution to stand overnight. 

STORAGE AND DISPOSAL 

STORAGE 

Do not contaminale water, food, or feed by storage or disposal. 

PESTICIDE DISPOSAL 

Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture, or rinsate is a 

violation of lederallaw. If these wastes cannot be disposed of by use according to label instructions, contact your 

State Pesticide or Environmental Control Agency orthe Hazardous Waste representative at the nearest EPA 

Regional Office for guidance. 

CONTAINER DISPOSAL 

Triple rinse (or equivalent) the empty containers. Then offer for recycling or reconditioning, or puncture and 

dispose of in a sanitary tandfill, or by incineration or if allowed by state and local authorities, by buming. If container 

is burned. stav out of smoke. 

102 
• 

• 

LIMITED WARRANTY AND DISCLAIMER 

The manulacturer warrants (a) that this product conforms to the chemical description on the label; (b) that this 

product Is reasonably fit for the purposes set forth in the direclions for use when II is used In accordance with such 

directions; and (c) that the directions, warning and other statements on this label are based upon responsible 

experts' evaluation of reasonable tests of effectiveness, of toxicity to laboratory animals and to plants. and of 

residues on food crops and upon reports of field experience. Tests have nol been made on all varieties or in all 

slates or under all condilions. THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR 

IMPLIED, AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF 

MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY 

AND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH 

IS INCONSISTENT WITH THE LABEL DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND 

ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS 

PRODUCT, WHETHER OR NOT BASED IN CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR 

OTHERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTION, TO REPLACEMENT OF, OR THE 

REPAYMENT OF THE PURCHASE PRICE FOR, THE OUANTITY OF PRODUCT WITH RESPECT TO WHICH 

DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, 

INDIRECT OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT . 

Rh6ne-Poulenc Ag Company 

P.O. Box t2014, 2 T.W. Alexander Drive 

Research Triangle Park, North CaroUna 2n09 

PREP is a trademark of RHONE-POUlENC. 

PREpT"l 4 Plant RegUlator for Collon (MASTER) Notification 619193. 

103 
• 

• 

PREpTM 4 PLANT REGULATOR FOR COTTON 

FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. 

NOT FOR RESIDENTIAL USE. 

ACTIVE INGREDIENT: 

Elhephon [(2-Chloroethyl) phosphonic acid]- 39.9% 

INERT INGREDIENTS: ....................................................... 60.1% 

-This product contains 4 pounds ethephon per gallon. 

EPA Reg. No. 264-380 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

etlquata Ie haya sido explicado-ampUameme. 

:rRANSLATION TO mE USER;-U-yOO-GaflAOt..fead-E+lglisR-GO-AOt use this produGt-VRtMhe label-has-been 

lully explained to you, 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyelids open and flush with a steady, gentle slream of water for at least 15 minutes. GET 

MEDICAL ATTENTION. PREFERABLY AN OPHTHALMOLOGIST. 

FOR ADDITIONAL PRECAUTIONARY STATEMENTS: See Inside Label 

For PRODUCT!J..S..E Information Call1·aOQ-334·9745 

For EMERGENCY Information oo.LY Call 24 Hours A Day 1·800·334·7577 

The use of this product lor a variety of plant growth regulation uses is covered by United States and larelgn patents including 

U,S, Patents 3,879.188 and 4.24O.8t9. No license is granled to use tllis product In countries other than the United States or 

tor any use not contemplated by this label. Uabillty tor patent infringement may resuk from use or sale of this product outside 

the United States. 

Rhone-Poulenc Ag Company 

Post Office Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, North Carolina 2n09 

PREP is a trademark of Rhone-Poulenc. MADE IN U.S.A. 

104 
PRECAUTIONARY' STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

Corrosive, 

1aG&-Shi~O'lQS 

Causes eye damage 

wneR-RaAdUAg. 

and skin irritation. Do not get in eyes, on skin, or on clothing. ~ 

Harmful or fatal if swallowed. Avoid contamination of food. 

STATEMENT OF PRACTICAL TREATMENT 

IF ON SKIN: Immediately wash with plenty of soap and water, Remove eoAtamiRatet:k*ethiA§-and shoes. lNaSR 

clothing separately bofore reus&: 

IF SWALLOWED: Do not induce vom~ing. Promptly drink a large quantity of milk, egg whites, gelatin solution 

or if these are not available, drink large quantities of water. Avoid alcohol. Call a physician immediately. 

IF INHALED: Remove victim to fresh air. If not breathing, give artificial respiration. Administer oxygen if tit necessary. GETMEO!CALATIENT!ON. 

• 

NOTE TO PHYSICIAN 

No specilic antidote Is available. All treatments should be based on observed signs and symptoms of distress in 

the patient. Overexposure to materials other than this product may have occurred. 

Victims of severe overexposure, by inhalation, should be kept under medical obselValion for up to 72 hours for 

delayed onset of pulmonary edema. In a victim of overexposure by ingestion, careful gastric lavage is required 

due to the possibility of stomach or esophageal perforation. This material is an acid, but the use of alkaline 

substances to neutralize it is contraindicated. 

ENVIRONMENTAL HAZARDS 

Avoid spray drift to nearby crops as this product may cause temporary modifications in plant growth. Do not 

contaminate water used for irrigation or domestic purposes . 

Forterrestrial uses, do not apply directly to water, orto areas where surface water is present or to intertidal areas 

below the mean high water mark. Do not contaminate water when disposing of equipment washwaters. 

Do not exceed the rate of PREpm per acre per year recommended on this label. 

DIRECTIONS FOR USE 

IT IS A VIOLATION OF FEDERAL LAW TO USE THIS PRODUCT IN A MANNER INCONSISTENT WITH ITS 

LABELING, 

Mixers, /Qadimi aR4applicakJ.r.s must wear-a-lu,ll facs shiBId, long trouseR;, kmg Sls81!8fi shi#rgloWiJSr8r/{j.bootS-to 

aw#d-as much sk~~~/e.. 

GENERAL INFORMATION 

A foliar spray of PREpm 4 Plant Regulator will accelerate opening of mature unopened cotton bolls and enhance 

defoliation which can result in earlier harvest with an increased recoverable yield. PREpTM 4 Plant Regulator 

treatment allows increased efficiency from a once-over harvest. 

Some premature drop of small, immature bolls may be associated with treatment Do not apply before sufficient. 

mature, unopened bolls have developed to produce the desired yield of callan. 

105 
• 

• 

A boll is mature when Ii is 100 hard to be denied when squeezed between thumb and fingers. 100 hard to be sliced 

with a sharp knife. and when the seed coat becomes light brown in color. 

For best results, thorough and uniform spray coverage is required. [t is essential that the bolls afe contacted by 

the spray to obtain optimum boll opening. Observe treated fields closely. Harvest at oplimun boll opening and 

defoliation, generally 14 to 21 days after treatment. Sustained cold weather with average day and night 

temperatures of 65°F or [ower after treatment with PREPTM 4 Plant Regulatorwil! delay the boll opening response. 

DO NOT APPLY PREP'" 4 PLANT REGULATOR [F RA[N [S EXPECTED WITH[N 6TO B HOURS. 

Rainfall within 610 8 hours of application may reduce product performance. 

Certified cotton seed growers should observe bon and seed maturity before treatment with PREpTM 4 Plant 

Regulator. Bolls not completely mature might open with freatment of PREprn 4 Plant Regulator giving [ower 

quality seed. 

Spray deposits of PREPTM 4 Plant Regulator, when left on aircraft acrylic plastic type windshields for longer than 1 

hour, may react with this material, forming an opaque film or spots on the surface which cannot be removed by 

washing with water or any other cleaner. Rinse windshields with water immediately after each tankfoad of PREflThl 

4 Plant Regu[ator has been appUed. Thoroughly rinse the aircraft with clean water after each day PREpn.! 4 Plant 

Regu[ator is applied. 

PREPTM 4 Plant Regu[ator may also affecf certain paints, and if accidental deposits on painted objects such as 

cars, trucks, agricultura[ equipment, etc. occurs, these objects should be rinsed with water as soon as possible 

(within 1 hour) to prevent permanent staining of the painted surface. 

SPRAY PREPARATION 

Add 112 to 3/4 of the required amount of water to the spray tank. Start agitation. Add the required amount of 

PREpTM 4 Plant Regulator, and the remaining amount of water. Prepare only as much spray solution as can be 

used on the day of mixing. Do not allow spray solution to stand overnight. 

Do not spill the concentrated product on spray equipment, or any airplane parts. ANY SPILLS SHOULD BE 

R[NSED [MMED[ATEL Y WrrH PLENTY OF WATER. 

Use of a nurse tank is highly recommended for avoiding possible spins of concentrated formulation on spray 

equipment or any airplane parts . 

EQUIPMENT CLEANING 

Because of the acidic nature of this product, prolonged exposure to spray deposit will damage acrylic plastics. 

certain paints, and metals. 

Rinse thoroughly with a detergent and water all exposed aCrylic plastic-type materials (e.g., aircratt wlndshie[ds), 

and painted surfaces within an hour after exposure to spray deposits. At the end of each day, rinse thoroughly 

with a detergent and water all the melal parts of the aircraft and the associated spray equipment exposed to the 

spray deposits. 

106 
8 

8 

aQLL QeENI~G 

Rates For Boll Opening 

CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 

5-7 DAYS AFTER PREprn 4 OF PREP'" 4 GAL.iACBE 

TREATMENT QUARTS/ACRE TREATS GROUND AIR 

Hot and dry eO'F or higher 1.0 (1.0 Ib aj.) 4 Acres t5 to 50 2 to 5" 

Dry with temperature 1.5 (1.5 Ib aj.) 2.5 Acres 15 to 50 2to 5" 

7S'Fto80'F 

Cool but higher than 6S'F 2.0 (2.0 Ib a.i.) 2 Acres 15 to 50 2 to 5· 

Rank cotton 2.0 (2.0 Ib a.i.) 2 Acres 25 to 50 5 

"NOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications 

Time of Application (BoU Opening) 

Apply when there are sufficient mature unopened bolls to produce the desired yield, but no later than when 60% 

of the bolls are opened {see General Information section on how to test for boll maturity}. Do not tank mix PREprn 

4 Plant Regulator with a desiccant if the cotton is to be spindle harvested. 

PRECQNDITIQNING FQR DEFQLIATION 

Rates For preconditioning For Defoliation 

CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 

5-7 DAYS AFTER PREP'" 4 OF PREP'" 4 GAL.!ACRE 

TREATMENT QUARTS/ACRE TREATS GROUND AIR 

Hot and dry aO"F or higher 0.5 (0.5 Ib a.i.) 8 Acres 15 to 50 2 to 5' 

Cool but higher than 65' and 1.0 (1.0 Ib a.i.) 4 Acres 15 to 50 2 to 5' 

also for rank cotton 

-NOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications. 

Time of Application (Preconditioning) 

Apply PREptM 4 to 7 days prior to application of defoliant or tank mixed with the defoUant (see section on 

Compatibility). Do not tank mix PREpn.! 4 with desiccants unless plant desiccation is required. 

Pre-treatment With Defoliants Prior to pRepm 4 plant Regulator Treatment 

[f the cotton is overly rank or laying down in the middles and good spray coverage of the bolts with PREpm 4 Plant 

Regulator is difficult. a pre1reatment with defoliants will be useful to improve bon coverage with PREpTM 4 Plant 

Regulator. Use dosage rates of PREpThI 4 Plant Regulator recommended for boll opening. Read and observe all 

appropriate label use directions and precautions for the defoliant used. 

Do not use a defoliant beiore there are sufficient mature unopened bolls 10 produce the desired yield (see 

General Information section on how th test for Boll Maturity). 

COMPATIBILITY 

PREpThl 4 Plant Regulator is compatible with DEF, FOLEX, DROPP, HARVADE, METHYL PARATHION, 

GUTHION AND MALATHION, and may be applied in sequence or as a tank mixture (DO NOT TANK MIX WITH 

107 
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• 

DEFOLtANTS OR DEStCCANTS IN CALIFORNIA AND ARIZONA). In some cases slight reduction in boll opening 

response has been observed when tank mixes with defoliants were used. 

Good agitation in the spray tank is essential and a tank mixture should not be allowed to stand without agitation for 

more than 5 to 10 minutes, Read and observe all appropriate label use directions and precautions for the 

defoliants and insecticides used. 

PRECAUTION: 00 NOT TANK MIX PREP'" 4 PLANT REGULATOR WITH DEFOLIANTS CONTAINING SODIUM 

CHLORATE BECAUSE THIS RESULTS IN THE FORMATION OF HYPOCHLOROUS ACIDS WHICH UPON 

HEATING EMIT TOXIC CHLORINE FUMES. 

WHEN TO HARVEST: Do not harvest cotton sooner than 7 days after a treatment with PREprM 4 Plant Regulator. 

Observe the treated crop and harvest when optimum boll opening has been reached. Too early harvest might 

reduce the full advantage of the treatment and too late a harvest may result in reduced quality and loss of Unt which 

will drop from the plant. 

USE PRECAUTIONS 

Avoid spray drift to nearby crops as this product will cause modifications in plant growth. Plant injury or reduced 

yields will result. 

Do not plant another crop within 30 days after treatment. 

Mix only the amount of spray you expect to use each day. Do not allow mixed solution to stand overnight. 

STORAGE AND DISPOSAL 

STORAGE 

Do not contaminate water, food, or feed by storage or disposal. 

PESTICIDE DISPOSAL 

Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture. or rinsate is a 

violation of federal law. If these wastes cannot be disposed ot by use according to label instructions. contact your 

State Pesticide or Environmental Control Agency or the Hazardous Waste representative at the nearest EPA 

Regional Office for guidance. 

CONTAINER DISPOSAL 

Triple rinse (or equivalent) the empty containers. Then offer for recycling or reconditioning, or puncture and 

dispose of in a sanitary landfill, or by incineration or if allowed by state and local authorities, by buming, If container 

is burned, stay out of smoke. 

108 
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LIMITED WARRANTY AND DISCLAIMER 

The manufacturer warrants (a) that this product conforms to the chemical description on the label; (b) that this 

product is reasonably fit for the purposes set forth in the directions for use when it is used in accordance with such 

directions; and (c) that the directions, warning and other statements on this label are based upon responsible 

experts' evaluation 01 reasonable tests 01 effectiveness, of toxicity to laboratory animals and to plants, and 01 

residues on food crops and upon reports of field experience. Tests have not been made on all varieties or in all 

states or under all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR 

IMPLIED, AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF 

MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY 

AND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH 

IS INCONSISTENT WITH THE LABEL DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND 

ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS 

PRODUCT, WHETHER OR NOT BASED IN CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR 

OTHERWISE SHALL BE LIMITED. AT THE MANUFACTURER'S OPTION, TO REPLACEMENT OF, OR THE 

REPAYMENT OF THE PURCHASE PRICE FOR, THE QUANTITY OF PRODUCT WITH RESPECT TO WHICH 

DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, 

INDIRECT OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT . 

RhOne-Poulenc Ag Company 

P.O. Box 12014,2 T.W. Alexander Drive 

Research Triangle Park, North Carolina 27709 

PREP is a trademark 01 RHONE·POULENC, 

PREP'" 4 Plant Regulator tor Cotton (MASTER) Notllicalion 619/93. 

109 
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• 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

Office of Pesticide programs 

Registration Division 

Warren A. Davis 

RHONE-POULENC AG COMPANY 

BOX 12014 

RESEARCH TRIANGLE PARK NC 27709 

Comment for: EPA Reg Nr.264-380 

PREP PLANT REGULATOR FOR COTTON 

The following specific comments pertain to your WPS 

labeling submission concerning the product 

cited above: 

Correct the typographical errors circled on your proposed 

label . 

110 
.~-~.-... 

• 

PI .. " on reverSf!1 before 01, IOMRN •. " '.".0' 

(A) aEPA 

I I nA,~" Registration lopp I 

Oflioo I- Washington, DC 20460 "g ... 188592 Application for Pesticide: I-

'-

" l't~Pe'les~~~o,;~ /3. I if 

14. CompanylProc!uct (Nama) IPM. ONona o AaSlriclod 

PREP 4 Plant Regulator for cotton 22 

15. Nama and Address 01 -, I fb)(i), my !rodUC1 is Si~i:;r or idQnlica~ ~ilh . ~3(C\:31 

(0: 

EPA Rag. No. 

o Chocl< if this is a nowaddro$$ , D. .. ". 

n I 

I- Amendment- Explain below ~_ :a_~.I~ -,in responso to -=: Aosubmission in response to Agency letter datod I-

~ Noulication· E:qllain below. . I-

"Mu Too· Application. 

Other - explain below. 

Usc additional pag6{s) il n&OOsury. (For IIOCrion 1 and Soetion ILl 

Notification: (PR Notice 93-3) labeling statement prohi:ii~ ~ to water. f 

} 

Section Itl .".,.. . M,to"" Thl. "'"".01 WUI •• d1", 

, . , 

I 

,<. ,~ol 8 Yes· I-/ Y

.' ~~:~ .• 

No No ~jN. Glass 

N~:.~r No. po< Papar .: ~a~~WgI. 011", • ClIrtlflcatlon must M contamar cont:lInor 

, .. ,. ;":' 

13. Location 01 Net Conlenlsinformalion ," S1'~'1 01 R"" 

El ,'~"" .. •••• 

o ""'" n Co 

• . 

• 

,S. , Whioh "'bel ITo Pro"'~ 

~ Dru. • , ::: . I 

• :. • 

I 1 , .. b. 

N,me In .. , No: ~ Warren Davis Isenior Registration Manager 919-5<w-aa'9 ... - is. r 

! C(lrtify that the statements 1 haYo made on \his form and all alUlchm9flts thOfOto are true, acrurate and completo. 

I acknowledge that any knowingly false or misleading statement may be punIshable by fino or imprisonment or (Stamped) 

both under appHcable law. 

I'· 1, /3 T,'. 

.,(;{/~ 1- {), , 

Req i'+ ,+', M.n,npr 

I"~ IS. 0". 

Warren Davis June 9. 1993 111 t'A .-orm II~/U' WOlI. EPA H" copy YO'~W " <Dpy 
PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

pAPERWORK REDUCTION ACT NOTICE: Public reportil'lD burden for-thiS, collection of infotfMtion f.>~.timated to average 0.85 hour per response, including time for reviewing instructionlt, searching existing data SOW-COB, gathering and 

maintaining the data needed, and cOIIpleting and reviewing thl! collection of in(ofll\Qtion. Send COImIOOts regarding the burden 

e&til1lllte or tInY other IlSpect of this colle<:tion of information, including suggeStions for reducing this burden, to Chief, 

Information Policy Branch, PH-223, U.S. EnvirOMJental Protection Ageney, 401 M Street, 5\1, Uashington, OC 2046tli and to the 

Office'of Information and Regulatory Affairs, Office of Mariagemont and Budget, Uashington, DC 20503. 

INSTRUCTIONS: This form is to be used for all applications for nw registration, end use reregistration, ~t, 

resu!::missfon, to applications for notifications, final printed labeling, reregistration, etc. ln ordltr to prOCI!:;s an 

application for a new registretion sul::l'flitted on this form, the following material IIJJSt acc~ the application: 

1. Certification with Respect to Citation of Ollto (EPA Form 8570·29). [If not exO!1lCpted by 40 CFR 152.81 (b) [4)); 

2. Confidential Statement of FOnP.Ila (EPA Form 857t1~4); 

3. Forll1Jlator's Excwption StatCltltnt (EPA Form 8570·27);' 

4. Five copies of draft labeling; 

5. Three copies of any data st.bnitted; 

6. Authorization letter where applicable; 

7. Matrices khere applicllble. 

Subnisslon of Lobeling - Ll\beling should first be submitted in the form of draft labels with all applicat;lons for new 

registration. Such draft label:; may be in the form of typed label text on 8.5 ;'It 1l inch P'lper or II mockup of the prop<lslld 

label. If prepared as a 1WC1tl:9, it should be construc:ted in such a way as to facilitat& stora~'in an 8.5 x 11 inch file. 

Mockup labels significantly smaller than 8.5 x 11 inches should be mounted on 8.5 x 11 inch paper for subnission. 

SUaission of Data - Data stb!!itted in s~rt of this application Il'USt be submitted in accordance wfth PR Notice 86·5. 

SPECIFIC INSTRUCTIONS: Please read the instructions listed below before cOll'pleting this application. first • 

determine the type of registration action, listed in Block A, for which you are submitting this application. For _ 

applications submitted in connection with Hew Registratlon actions, Sectiorn'l I, III, aOO IV I!tJst be cowpleted by the 

applicant. For applications submitted in connection wjth amended registration actions, resubmi:;sions, notifications, 

reregistrations, etc., Sections I, TI, and IV rust be cOilpleted by the applicant. 

Slode A - Check the appropriate action for which you are sU:mitting this form. 

SECTION I - This section Il'U$t be cooplete<:i, as applicable, fQr all registration actions. 

1. CoIIpany/Prcxb::t Insert your co.pony 1fUIther, if ono: has been assigned by EPA. This m.nber may hive bHn assigned 

to you as a b.!Islc 4 distributor, or as an establishment. If your product is registered, insert the Pn:dJet 

Nu.ber. ; 

2. EPA Product the I'InII» and PM nutber of the EPA Product Manager. 

3. classification of this prc4Jct. 

4. of this pesticide as it will appeor on the label. The name ~t be 

specific to of l"IIlI!'IeS is not permitted IimOI"IO prodUcts of the S/IIM conpany~'" 00 not incl~ 

any brand name or company 

5. Matle ard Address ,of Applfcoot - The naHiC" of the finn or person, and address shown in your application,l$ the p4r$oo or fil'1ll 

to whom the registration will be issued. If you are acting- in behalf of another party, you Jl)Js.t sl.bnit iWthori:l:ation from 

that party to act for them in registration matters. An applicant not residing in the United States must have an 

authorized agent residing in the United States to act for them in all registration matters. The ~ ond complete 'mailing 

address of such an agent _t acc~ this applic3tion. 

6. ~ited Review - FlFRA section 3 (c) 3 [8) provides for expedited review of applications ior regIstration, or,amendments 

to cxisting tegistrations, that are similar or identical to other pesticide products that are currently registered with _ 

the EPA. IfIIto.rder for your application to be eligible for expedited revi~, you Il'Ust provide us with the,EPA Registrati~ 

.. ~r 11M p10duct rwme- of the pr<Xkx:t you believe is similar to or identiclll to your product. The product I'fJJSt be 

: ~imtlar or. "fe1'tjcal in both form;lation III1d labeled uses. 

'mION Ii . -;his s.u:tion It'IJst be conpleted for all applicDtiorn'l sublIitted to emend the registration only of a currrotly 

r~·btered pr~J "AmorxiMnt), for a reslJtfflission in respc:;Me to an Agency letter, for notifications to the Apncy, for the 

,00000Uion of'''f'IMt!.prlnted labeling, for reregistration and for any other fiction thllt pertains to a $pe(:ifle ru-CHhteroo 

~. Thh; section is!!!ll 12 21! used for 4 new application for registration. 

1. ,&bjec:t: of. \tldi,p,sicn - Check: the npplicable block: and prOVide the Agency letter date if Appropriate. Provlde a bl"ief 

•• .wlanutiOl'fM'"the purpose(s) for th~ sui:missiOfl, such liS lOthe addition of a site, past or crop (sp«;ifY)"i lfaMnd the 

• l"'tmfidential.Suternent of fornula by ••• "; "rere-gistration subnlssion-"; gwral label revision of use directions." Attach ··a scp.arate<fiilgeJf additional s!)Gce is rweded. : .. :.. . ..... :,. S'eC'PlON III I.Packaging and Container Information) - This Sec,tion Il'USt be coopleted for all applications 

sul:mitted in:C~ion with ~ registration or applicable IIfIIOfldaents. 

1. Type of Pec"bQu'G - Checlt the appropriate block if your product will be p4Cltag&d in the indicated packaging types. 

lOOicate the- she of the individulll packets and flI.Jfber per retail container. 

2. Type of Retail container - Indicate type of container in which prockJct will bii IIIDrketed. 

3. Location of Met Ccntents - sp.ecify the net contents of aU retail containers for your product. 

4. Sixe(s) J)f'Retail Container - speclfy the net contents of nll retail containers for your product. 

5. Locution of IJI.e Dir«tione. - Indicate the location of the use directions. for your product. 

6, ~ in .bich lobel ill: affixed to pnxb:t - IOOiclltl/ the IliIethod product label is attllched to retail container. 

SECTION IV {Contact Point} - This $ectiOflll'USt 00 cOll1)leted for IIll applications for Registration actions, i.e., 

MW products registration, resubmission, lime· too," reregistration, etc. 

1-5. Self-explanatory. 

6. EPA USe only. 

112 
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• 

LABEL INFORMATION PAGE 

PREpTM 4 PLANT REGULATOR FOR COTTON 

MASTER LABEL 

Routing: 

Product Development 

Product Manager 

Others 

Legal 

State Registrations 

Registration Manager 

General label revisions: 

• Notification 6/9/93 • revised wetlands statement. 

Rate changes for the following: 

• CA restrictions: 

Printing Restrictions: • ••• 

• •••••• 

•••• • • • 

• ., • • • • • •••••• 

• • • 

•• 

• • •••••• • •••• 

• • • ••••• 

•••• 

• • • •••• · -.... • • • 

•• 

• •• 

• • • •••••• 

•••• • • •• . , • • 

• • • •• ., 

113 
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PREP"" 4 PLANT REGULATOR FOR COTTON 

FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. 

NOT FOR RESIDENTIAL USE. 

ACTIVE INGREDIENT: 

Ethephon [(2oChioroethyQ phosphonic acid}' 39.9% 

INERTINGREOIENTS: .. _ •.•...............................................•. 60.1% 

-This product contains 4 pounds ethephon per gallon. 

EPA Reg. No. 264·380 EPA Est. No. 264-PA-01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUCION AL USUARtO: Si USled no lee ingles, no use este producto hasla que la informacion en la 

eliqueta Ie haya sldo explicado ampliamenle. 

TRANSLATION TO THE USER: If you cannot read English do not use this product until the label has been 

fully explained to you. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyelids open and flush with a steady, gentle stream of water for at least 15 minutes. GET 

MEDICAL ATTENTION. PREFERABLY AN OPHTHALMOLOGIST. 

FOR ADDITIONAL PRECAUTIONARY STATEMENTS: See Inside Label 

For PAOPUCTllS.f Information Call1-aOO-334-9745 

For EMERGENCY Infonnalion ONLY Call 24 Hours A Day 1-800..a34-7577 

Tho usc of this product for a varioty of plant growth regulation USGS is covored by Unitod Stalos and 10reign patottts including 

U.S. Patents 3,879,188 and 4,240,819. No licGnse Is granted to use this product in countrios other than the UniMKf States or 

for any use not contemplated by this label. liability for patent Infringement may result from use or sale of this pr.o£kJct outs:cr .. :·: 

the United States. • ...: • • 

Rhone-Poulenc Ag Company 

Post Office Box 120t4, 2 T.W. Alexander Drive 

Research Triangle Park, North CarOlina 2n09 

PREP is a trademark of Rhone~Poulenc. 

• 

.... • .. • 

• 

•••• • • •••• 

MADE IN U.S.A. 

• •• •• • •••• 

• • • •• •• •• 

114 

• ••••• 

• • •• 

• •••• • • ••••• 

• 

• ••••• • • 

•• 

• ••••• • • • ••• 
• 

• 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

Corrosive. Causes eye damage and skin irritation. Do not get in eyes, on skin, or on clothing. Wear goggles or 

face shield and rubber gloves when handling. 

Hannful or fatal If swallowed. Avoid contamInation of food. 

STATEMENT OF PRACTICAL TREATMENT 

IF ON SKIN: Immediately wash with plenly of soap and waler. Remove contaminated clothing and shoes. Wash 

clothing separately before reuse. 

IF SWALLOWED: Do not induce vomiting. Promptly drink a large quantity of milk, egg whites, gelatin solution 

or if these are not available, drink large quanllties of water. Avoid alcohol. Call a physician Immediately. 

IF INHALED: Remove victim to fresh air. If not breathing, give artificial respiration. Administer oxygen if 

necessary. GET MEDICAL ATIENTIDN . 

NOTE TO PHYSICIAN 

No specific antidote is available. All treatments should be based on observed signs and symptoms of distress In 

the patient. Overexposure to materials other than this product may have occurred, 

Victims of severe overexposure, by inhalation, should be kept under medical observation for up to 72 hours for 

delayed onset of pulmonary edema. In a victim of overexposure by Ingestion, careful gastric lavage is required 

due to the possibility of stomach or esophogeal perlorallon. This material Is an acid, but the use of alkaline 

substances to neutralize it is contraindicated. 

ENVIRONMENTAL HAZARDS 

Avoid spray drift to nearby crops as this product may cause temporary modifications in plant growth. 00 not 

contaminate water used for inigation or domestic purposes. 

For terrestrial uses, do not apply directly to water, to areas where surface water is present or to Intertidal areas 

below the mean high water mane 00 not contaminate water when disposing of equipment washwaters. 

Do not exceed the rate of PREPTM per acre per year recommended on this label. 

GENERAL INFORMATION 

A foliar spray of PREpn.t: 4 Plant Regulator will accelerate opening of mature unopened cotton bolls a"q enhance 

defoliation which can resutt in earlier harvest wilh an Increased recoverable yield. PREpn.! 4 Plant Re,QJJtJtor : •• :.: 

treatment allows increased efficiency from a once.()ver harvest. •••• : • • 

Some premature drop of small, immature bolls may be associated with treatment. 

mature, unopened bolls have developed to produce the desired yIeld of cotton. 

•••••• 

• •• Do not apply befa,re sufficient, •• 

• ••••• • •••• • • • ••••• •••• 

A boll is mature when it is too hard to be dented when squeezed between thumb and fingers, too Ma:Uc~ be sliced • 

with a Sharp knife, and when the seed coat becomes light brown in color. • •• : •• : 

•• 

• •• " ... ..... . For best results, thorough and uniform spray coverage IS required. tt Is essential that the bolls are COliltaoted by ••• •• 

the spray to obtain optimum boll opening. Observe treated fields closely, Harvest at optimun boll o~nLnQ: and • 

defoliation, generally 14 to 21 days after treatment. Sustained cold weather with average day and night •• 

temperatures of 65°F or lower after treatment with PREpTM 4 Plant Regulator will delay the boll opening response. 

115 
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• 

...... _. __ ........... ............. •••....... --.. --~-

DO NOT APPLY PREP'" 4 PLANT REGULATOR IF RAIN IS EXPECTED WITHIN 6 TO 8 HOURS. 

Rainfall within 6 to B hours ot application may reduce product perfonnance. 

Certified cotton seed growers should observe boll and seed maturity before treatment with PREpTJ.! 4 Plant 

Regulator. Bolls not completely mature might open with treatment of PREpn.c 4 Plant Regulator giving }ower 

quality seed. 

Spray deposits of PREpi'M 4 Plant Regulator, when left on aircraft acrylic plastic type windshields for longer than 1 

hour, may react with this matertal, forming an opaque 111m or spots on the surface which cannot be removed by 

washing with water or any other cleaner. Rinse windshields with water Immediately after each tank/oad of PREpnt 

4 Plant Regulator has been applied. Thoroughly rinse the aircraft with clean water after each day PREpm 4 Plant 

Regulator is applied. 

PREpnt 4 Plant Regulator may also affect certain paints, and if accidental deposits on painted objects such as 

cars, trucks, agricultural equipment, etc. occurs, these objects should be rinsed with water as soon as possible 

(within 1 hour) to prevent permanent staining of the painted surface. 

SPRAY PREPARATION 

Add 1/2 to 314 of the required amount of water to the spray tank. Start agitation. Add the required amount of 

PREpt'N 4 Plant Regulator, and the remaining amount of water. Prepare only as much spray solution as can be 

used on the day of mixing. Do not allow spray solution to stand overnight. 

Do not spill the concenlrated product on spray equipment, or any airplane parts. ANY SPILLS SHOULD BE 

RINSED IMMEDIATELY WITH PLENTY OF WATER. 

Use of a nurse tank is highly recommended for avoiding possible spills of concentrated tormulation on spray 

equipment or any airplane parts. 

EQUIPMENT CLEANING 

Because of the acidic nalure ot this product, prolonged exposure to spray deposit will damage acrylic plastics, 

certain paints, and metals. 

Rinse thoroughly with a detergent and water all exposed acrylic plastic-type materials (e.g., aircraft windshields), 

and painted surfaces wHh!e an hour aUer exposure to spray deposits. Altha end of each day. rinse thoroughly 

whh a detergent and water all the metal parts ot the aircraft and Ihe associated spray equipment exposed to the 

spray deposits . 

DIRECTIONS FOR USE 

IT IS A VIOLATION OF FEDERAL LAW TO USE THIS PRODUCT IN A MANNER INCONSISTENT WITH ITS 

LABELING. 

Mixers, loadelS and applicators must wear a fuJI face shield. Jong trousers, long sleeved shirt, gloves, and boots to 

avoid as much skin and eye contact as possible. .:. 

• •••••• 

Do not enter treated lields within 24 hours after application unless protective clothing is worn. •••• • • • 

• .. • • • • • •••••• 

• • • .. • • •••••• • •••• 

• • • • •••• 

•••• 

• • • •••• 

• ••••• 

• • .. • 

• .. • • • • ••••• •••• .. • .. • 

• • • .. • .. • 

116 
8 

8 

BOLL OeEtlltlG 

Rates For Boll Opening 

CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 

5-7 DAYS AFTER PREpTM 4 OF PREpTM4 GALIACRE 

TREATMENT QUARTS/ACRE TREATS GROUND AIR 

Hot and dry 80-F or higher 1.0 (1.0 Ib a.l.) 4 Acres 15 to 50 2 to 5· 

Dry with temperature 1.5 (1.Slb a.l.) 2.5 Acres 15 to 50 2 to 5-

7S·Fto8Q"F 

Cool but higher than SS'F 2.0 (2.0 iJ a.i.) 2 Acres 15 to 50 2 to 5-

Rank cotton 2.0 (2.0 Ib a.l.) 2 Acres 25 to 50 5 

-NOTE: For Callfomia and Arizona use a volume of no less than 5 gallons per acre for aerial applications 

Time of Application (Boll Opening) 

Apply when there are sufficient mature unopened bolls to produce the desired yield, but no later than when 600/0 

of the bolls are opened (see Generallnfonnation section on how to test for boll maturity). Do not tank mix PREf>T1'I 

4 Plant Regulator with a desiccant if the cotton Is to be spindle harvested. 

eBECOtlQITIOtlltlG FOR QEEOLIATIOtl 

Bates For preconditioning For DefollatlQn 

CONDITIONS EXPECTED ONE GALLON SPRAY VOLUME 

5-7 DAYS AFTER PREP"" 4 OF PREpTM4 GALIACBE 

TREATMENT QUARTS/ACRE TREATS GROUND AIR 

Hot and dry BO"F or higher 0.5 (0.5 Ib a.l.) 8 Acres 15 to 50 2 to 5-

Cool but higher than 65'and 1.0 (1.0 Ib a.l.) 4 Acres 15 to 50 2 to 5· 

also for rank cotton 

·NOTE: For Califomia and Arizona use a volume of no less 1han 5 gallons per acre for aerial applications. 

Ilme of Application (Precondftfonlng) 

Apply PREP"" 4 to 7 days prior to application of defoliant or tank mixed with the defoliant (see section 0lI 

Compatibility). Do not tank mix PREPnI 4 with desiccants unless plant desiccation is required. .:. 

• ••••• 

• ••• • •• pre~treatmeDt With pefollants prior to PBEpTM 4 plant Regulator Treatment .... : • • 

If the cotton Is overly rank or laying down In the middies and good spray coverage of the bolls with PREpni 4 Plant:··: 

Regulator is diffICUlt. a pretrealment with defoliants will be useful to improve boll coverage with PREr. 4:~lant •• :: 

Regulator. Use dosage rates of PREPTM 4 Plant Regulator recommended for boll opening. Read aRa obServe ~I. • 

appropriate label use directions and precautions for the defoliant used. • •••• • ..: • 

•••• 

Do not use a defoliant before there are sufficient mature unopened bolls to produce the desired yield (see 

Generallnfonnation section on how th test for Boll Maturity). : •••• 

•••• 

COMPATIBILITY ••• : 

PREP"" 4 Plant Regulator is compatible wnh DEF, FOLEX, DROPP, HARVADE, METHYL PARATHION,.· 

GUTHION AND MAlATHION, and may be applied In sequence or as a tank mixture (DO NOT TANK MIX WITH 

117 

• ••••• • • •• 

• ••••• 

• • • ••• 
• 

• 

DEFOLIANTS OR DESICCANTS IN CALIFORNIA AND ARIZONA). In some cases slight reduction In bog opening 

response has been observed when tank mixes w~h defoliants were used. 

Good agitation in the spray lank Is essential and a tank mixture should not be allowed to stand without agitation for 

more than 5 to 10 minutes. Read and observe all approprfate label use directions and precautions for the 

defoliants and insecticides used. 

PRECAUTION: DO NOT TANK MIX PREP'" 4 PLANT REGULATOR WITH DEFOLIANTS CONTAINING SODIUM 

CHLORATE BECAUSE THIS RESULTS IN THE FORMATION OF HYPOCHLOROUS ACIDS WHICH UPON 

HEATING EMIT TOXIC CHLORINE FUMES. 

WHEN TO HARVEST: Do not harvest cotton sooner than 7 days after a treatment with PREpn.! 4 Plant Regulator. 

Observe the treated crop and harvest when optimum boll opening has been reached. Too eal1y harvest might 

reduce the full advantage of the treatment and foo late a harvest may result In reduced quality and loss of lint which 

wig drop from the plant. 

USE PRECAUTIONS 

Avoid spray drift to nearby crops as this product will cause modifications in plant growth. Plant Injury or reduced 

yields will result . 

00 not plant another crop within 30 days after treatment. 

Mix only the amount ot spray you expect to use each day. Do not allow mixed solulion to stand overnight. 

STORAGE AND DISPOSAL 

STORAGE 

Do not contaminate water. food, or feed by storage or disposal. 

PESTICIDE DISPOSAL 

Pesticide wastes are acutely hazardous. Improper disposal ot excess pesticide. spray mixture, or linsate Is a 

violation of federal law. If these wastes cannot be disposed of by use according to label instructions, contact your 

State Pesticide or Environmental Control Agency or the Hazardous Waste representative at the nearest EPA 

Regional Office for guidance. 

CONTAINER DISPOSAL 

Triple rinse (or equivalent) the empty containers. Then offer for recycling or reconditioning, or puncture and 

dispose of In a sanitary landfill. or by incineration or if allowed by slale and local authorities, by burning. ff container 

is burned stay out of smoke. 

• ••• • •••••• •••• • • • • • • • • 

•• • • ••••• • • • 

•• 

• • • ••••• • •••• • • • ••••• ~ ... • • • •••• · ...... • • • •• • .. • • • •••••• •••• .. • .. • 

• • • · .. .. • 

118 
• 

• 

LIMITED WARRANTY AND DISCLAIMER 

The manulacturer warranls (a) Ihallhis product conlorms 10 the chemical description on the label; (b) lllal this 

produCI is reasonably tit lor the purposes set forth In the directions for use when It is used in accordance with such 

directions; and (C) that the direcllons, warning and olher sta1emenls on Ihis label are based upon responsible 

experts' evaJualion of reasonable tesls of effectiveness, of loxlcJty to laboralory animals and to plants, and of 

residues on 1000 crops and upon reports of lield experience. Tests have not been made on all varielies or in all 

state. or under aU condlions. THE MANUFACTURER NEITHER MAKES NCR INTENDS, NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR 

IMPLIED, AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTiES OF 

MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY 

AND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH 

IS INCONSISTENT WITH THE LABEL DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND 

ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS 

PRODUCT, WHETHER OR NOT BASED IN CONTRACT, NEGLIGENCE. STRICT LIABILITY IN TORT OR 

OTHERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTiON, TO REPLACEMENT OF, OR THE 

REPAYMENT OF THE PURCHASE PRICE FOR, THE QUANTITY OF PRODUCT WITH RESPECT TO WHICH 

DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, 

INDIRECT OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT . 

• ••• • •••••• 

RhOno·Poulrmc Ag Company 

P.O. Box 12014, 2 T.W. Alexandor Drive 

Research Triangle Park, North Carolina 27709 

PREP is a trademark 01 RHONE·POULENC. 

PREpnI 4 Plant Rogulator for Colton (MASTER) Notification 619193. 

•••• • • • •• • 

• 

• • •••••• • 

•••• • • •••• 

• •• • • • •••• 

• • • • • •• •• 

119 

• • • • • 

•••••• • • •• 

• •••• 

...... • • 

• · ...... 

• • •• 

• ••••• • • •• •• 
· ... 

~ , 

~ RHONE-POULENC 

• 

• 

RH6NE-POULENC AG COMPANY 

June 8,1993 

U. S. Environmental Protection Agency 

Office of Pesticide Program Document Processing Desk 

Room 266 A, Crystal Mall No.2 

1921 Jefferson Davis Highway 

Arlington, Virginia 22202 

Attention: Ms. Cynthia Giles-Parker 

Product Manager (22) 

Fungicide Herbicide Branch 

Registration Division (H7505C) 

Dear Ms. Parker: 

RE: Notification 93-3 

Definition of wet lands 

Florel Plant Regula tor 

EPA Reg No 264-263 

Prep brand Ethephon for cotton and Tobacco 

EPA Reg No 264-418 

Cerone 2 Plant Regula tor 

EPA Reg No 264- 376 

Ethrel Ethephon Plant Regulator for Pineapples and Sugarcane 

EPA RegNo 264-257 

Cerone 4 Plant Regulator for Cotton 

EPA Reg No 264-380 

Ethrel Plant Regulator 

EPA Reg No 264-267 

Cerone Plant Regulator 

EPA Reg No 264-377 

o 000 

00 0 

o 0 0 

o 

... 

o " • . 0 

o 

...... o 0 

• Appended are application forms and labels for the following ethephon containil.tg.p1:oducts:.. o • 

o o 00 

The statement" For terrestrial use, do not apply directly to water, to areas where surface wale,,: 

is present or to intertidal areas below the mean high water mark" has been added to each labcl 

under the Environmental Precautions Section. : .' 8 • • 

Sillcerely, 

.z:/~-- ~ d~_A':' 

Warren A. Davis 

PO BOX 1~pjR9 J\~!~tA"eMStn Manager 

fi,,-SEARCH TR'ANGU:' r;CRr:: NC /leU) 

1['f9) 5-18 2\J{)() 

:NTEHNMiONAL 7no. f<0V,SLR .1<)<YD f!J ,\1<.:,',',,< ,,8!<>< N'C HlP 

iNTf:l1tiATiQtML iJlSW'UUrlQN srfl'.-,!";C; 1"1.f1 I il)'.lE[fl .:¥.f(:i; --<'.f,SWLR8N:K M-": iU:_, 

000 

• 0 

o 0 

00 0 

Excelfence itl Performance 

P"Ue In AC/llevernelli 

120 
Pages 121-134-*Confidential Statement of Formula may be entitled to confidential treatment*
Pages 135-138-*Inert ingredient information may be entitled to confidential treatment*