Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF 

CHEMICAL SAFETY 

AND POLLUTION PREVENTION 

MEMORANDUM

DATE: November 16, 2010 

SUBJECT: Aggregate Dietary Assessment of the Common Metabolite/Degradate Ethylene 

Thiourea (ETU) to Support New Tolerances on Imported Grapes and Bananas for 

Metiram and for New Tolerances for Mancozeb on Almonds, Broccoli, Cabbage, 

Lettuce, and Peppers. 

PC Codes: 600016, 14504, 14505, 14601 DP Barcode: D366141 

Decision No.: 299414 Registration No.: NA 

Petition No.: PP# 9E6006 PP#4F4324 and 4F4333 Regulatory Action: New Tolerance 

Risk Assessment Type: Dietary Aggregate Case No.: NA 

TXR No.: NA CAS No.: 96-45-7; 8018-01-7; 12427-38-2; 9006-42-2 

MRID No.: NA 40 CFR: 180.176, 180.110, 180.217

REVIEWER: Christine L. Olinger, Chemist 

Risk Assessment Branch 7 

Health Effects Division (7509P) 

THROUGH: Michael S. Metzger, Chief 

Risk Assessment Branch 7 

Health Effects Division (7509P) 

Thurston Morton, Chemist 

Amelia Acierto, Chemist 

Dietary Exposure Science Advisory Council 

Health Effects Division (7509P) 

TO: Cynthia Giles-Parker, Chief 

Fungicide Branch 

Registration Division (7505) 

Executive Summary

BASF Corporation has submitted a petition for tolerances on imported bananas and wine grapes 

for the fungicide metiram and Dow AgroSciences LLC has submitted petitions for tolerances on 
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almonds, broccoli, cabbage, lettuce, and peppers for the fungicide mancozeb. Metiram and 

mancozeb are in the class of ethylene bisdithiocarbamate fungicides (EBDCs), which all produce 

the common metabolite and environmental degradate, ethylenethiourea (ETU). Maneb is a third 

fungicide registered for use in the United States that belongs to the EBDC group, but no 

proposed changes in maneb residues have been addressed in this assessment. This memorandum 

reports the results of an aggregate dietary exposure analysis for ETU, resulting from existing and 

proposed uses of metiram, mancozeb, and maneb. The most recent dietary exposure analysis 

was conducted in support of the subject actions (C. Olinger, 4/17/2007, DP Barcode D 337240). 

The assessment included in this memo reflects revised usage estimates and updated information 

on the banana residue data. Only the dietary assessment for cancer endpoint is included in this 

review, as acute and chronic risks for ETU were not of concern in previous assessments. Note 

that the previous assessment for metiram included all grape commodities, but the petitioner has 

amended the request to include only wine grapes. 

Separate dietary exposure assessments were previously conducted for metiram (C. Olinger, DP 

Barcode D326753, 4/17/07 and mancozeb (C. Olinger, DP Barcode D323878, 4/17/07). In each 

of these assessments, human dietary exposure and health risk associated with the active 

ingredient were estimated. Also addressed in each of these previous assessments are the dietary 

exposure and risk resulting from consumption of ETU residues derived from each EBDC 

individually. ETU has been demonstrated to be a direct-acting carcinogen and has been the 

subject of toxicology studies from which HED has selected the most appropriate and sensitive 

toxic effects and doses to serve as the hazard component of risk. The overall dietary exposure 

resulting from the combined sources of ETU are evaluated in this document . Field trial or 

monitoring data from the EBDC/ETU Market Basket Survey, percent crop treated information, 

and extensive processing study results are used for existing uses. For the proposed new uses and 

tolerances field trial data, processing factors, projected percent crop treated (for the proposed 

mancozeb new uses), and percent imported (for the proposed metiram tolerances) are used to 

refine residue estimates. 

Cancer Dietary Exposure Results and Characterization

The aggregate cancer risk estimate associated with exposure to ETU from all EBDCs for food 

and water is 2.8 x 10-6 for the general U.S. population. 

The aggregate acute, chronic, and cancer assessments can be considered refined. Residue 

estimates were refined using consumer processing factors (washing, cooking), commercial 

processing factors (winemaking, juice), percent crop treated factors (existing domestic uses 

only), and market basket survey (monitoring) data for several of the existing uses. Percent crop 

treated information was used to refine the estimates for the proposed new uses of mancozeb. 

Percent crop treated information is not available for the uses on imported crops (bananas and 

wine grapes), residue estimates were refined using percent imported. Crop field trial data were 

used for several of the existing uses as well as all of the proposed new uses, which are likely to 

provide higher estimates than actual exposures. The greatest contributors to the dietary exposure 

for the cancer assessment were leafy vegetables, Brassica vegetables, fruiting vegetables, and 

water. 
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I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point 

of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors. 

HED generally expresses concern when risks exceed 100% of the acute or chronic PAD. For 

cancer risks, calculated risks greater than one in one million are ordinarily considered to be of 

concern. References which discuss the acute and chronic risk assessments in more detail are 

available on the EPA/pesticides web site: “Available Information on Assessing Exposure from 

Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-AUG-1999). 

The current document addresses cancer exposure from ethylene thiourea (ETU). The most 

recent ETU aggregate dietary exposure analysis was conducted in support of this action (C. 

Olinger, 4/17/2007, DP Barcode D 337240). 

II. Residue Information

In 1977, the Agency initiated a Special Review and Continued Registration of Pesticide Products 

containing ethylene bisdithiocarbamates (EBDCs). The need for Special Review of the EBDCs 

was based on evidence suggesting that the EBDCs and ethylenethiourea (ETU), a metabolite and 

degradation product of these pesticides, posed potential risks to human health and the 

environment. In 1982, the Agency concluded this Special Review by issuing a Final 

Determination (PD 4) which required risk reduction measures to prevent unreasonable adverse 

effects pending development and submission of additional data needed for improved risk 

assessment. 

In 1987, EPA issued a second Notice of Initiation of Special Review of the EBDC pesticides 

because of health concerns caused by ETU. The Special Review’s Preliminary Determination 

(PD 2/3) was published on 12/20/89 (54 FR 52158) and the Final Determination (PD 4) on 

3/2/92 (57 FR 7484). 

The EBDC tolerance expressions has been revised to include residues of the parent EBDC, 

calculated as CS2, rather than as zineb. Dietary exposure and risk assessments will continue to 

include residues of ethylene thiourea (ETU), a metabolite common to all EBDCs. This change 

allowed the Agency to harmonize its EBDC tolerance definitions with CODEX. 

Residue Data Cancer Assessments

A summary of the residue inputs can be found as an attachment to this document. BASF 
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Corporation submitted banana and grape residue data, as well as grape processing data, and Dow 

Agrosciences submitted residue data for almonds, broccoli, cabbage, lettuce, and peppers. 

Attachment 1 to this document includes a detailed description of the estimation of the anticipated 

residues for the proposed new tolerances. 

Chronic Anticipated Residues

Chronic anticipated residues were also calculated from field trial or monitoring data. Averages 

of the field trials were used for the new tolerances, while field trial and market basket survey 

data were used for established uses. Additional information on residue inputs may be found in 

the following memoranda: C. Olinger, 4/17/2007, DP 337240; F. Fort, 5/26/05, 305131. 

Usage Data

BEAD provided information on the percent crop treated (%CT) for most of the existing uses. 

For the proposed new metiram tolerances, percent imported was used as a surrogate for percent 

crop treated as all of the proposed new tolerances are for imported commodities, and percent 

crop treated information from the foreign uses are not available. BEAD estimated 100% imports 

for bananas and 20% for wine. For the chronic analysis, the weighted average %CT was 

incorporated; for the acute analysis, the estimated maximum %CT was used when appropriate. 

Percent crop treated information was estimated for the proposed new uses of mancozeb. 

Additional information can be found in the document, Ethylene bisdithiocarbamates [Mancozeb, 

Maneb, and Metiram]. Summary of Percent Crop Treated (%CT), and Justification for Use of 

the 1990 EBDC Market Basket Survey in Dietary Exposure Assessments for Reregistration 

(Barcode Nos. D290139, D290140, and D290137, 9/4/03, C. Swartz). Screening Level Usage 

Analyses (SLUAs) for the existing uses of all EBDCs are attached as well. The usage 

information was provided in six documents from BEAD, which are all attached to this 

assessment (Attachments 2-7). 

Processing Factors

The processing factors were obtained from processing studies submitted by the registrant and 

were compiled in a memo entitled “Reregistration of Mancozeb, Maneb, and Metiram: 

Processing and Cooking Factors to be Used in the Dietary Risk Assessment”, C. Olinger, 

11/5/2003, DP Barcodes D289569; D289570; D289571. These factors include cooking, peeling, 

washing and processing factors. Wine processing data from metiram specific studies submitted 

in support of the petition were used as well. 

III. Drinking Water Data 

The Environmental Fate and Effects Division (EFED) has provided information on the ability of 

the EBDCs and the degradate ETU to reach drinking water sources (Ruhman and Parker, 

8/11/06, DP Barcodes D323143 and D323141). The EBDC fungicides are expected to degrade 
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relatively quickly in the environment, so the parent compounds are not expected to reach 

drinking water sources. EFED has estimated drinking water concentrations of ETU in surface 

water and groundwater using monitoring data, and modeled estimates where monitoring data are 

not available. According to the 8/11/06 memo, 

• the chronic EDWC for surface water is 0.1 ppb of ETU based on a monitoring study 

conducted by the EBDC Task Force; 

 

• A range of acute EDWCs is established with a lower limit of 0.1 ppb of ETU (based on 

monitoring) and an upper limit of 25.2 ppb of ETU (based on environmental fate and 

transport simulation modeling using the linked EPA PRZM and EXAMS models); and 

 

• The ground water EDWC is 0.21 ppb of ETU (based on a targeted monitoring study). 

Water residues were incorporated in the DEEM-FCID into the food categories “water, direct, all 

sources” and “water, indirect, all sources.” The distribution of outputs from PRZM/EXAMS was 

used for the acute assessment and the groundwater EDWC was used for the chronic and cancer 

assessments, as these estimates provided an upper bound estimate of water exposure. 

IV. DEEM-FCIDTM Program and Consumption Information

ETU acute, chronic and cancer dietary exposure assessments were conducted using the Dietary 

Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCIDTM, 

Version 2.03), which incorporates consumption data from USDA’s Continuing Surveys of Food 

Intakes by Individuals (CSFII), 1994-1996 and 1998. The 1994-96, 98 data are based on the 

reported consumption of more than 20,000 individuals over two non-consecutive survey days. 

Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, 

peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using 

publicly available recipe translation files developed jointly by USDA/ARS and EPA. Consumption 

data are averaged for the entire U.S. population and within population subgroups for chronic 

exposure assessment, but are retained as individual consumption events for acute exposure 

assessment. 

For chronic exposure assessments, an estimate of the residue level in each food or food-form (e.g., 

orange or orange juice) on the food commodity residue list is multiplied by the average daily 

consumption estimate for that food/food form. The resulting residue consumption estimate for each 

food/food form is summed with the residue consumption estimates for all other food/food forms on 

the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed 

in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each 

population subgroup. 

V. Toxicological Information

The HIARC evaluated the toxicology database of ETU on February 20, 2003 and selected the 
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doses and endpoints for risk assessment based on a variety of exposure pathways resulting from 

use of the EBDC fungicides (K. Farwell, TXR# 0051924, 5/28/03). These are shown in the 

Table 1 below. 

The HED Cancer Assessment Review Committee classified ETU as a group B2 probable human 

carcinogen (Bill Sette, Ph.D. memo, 4/16/90 and Albin Kocialski, Ph.D. memo, 9/26/91). The 

cancer slope factor for ETU, using a 3/4 scaling factor, was determined to be 6.01 x 10-2

(mg/kg/day)-1 based upon female mouse liver tumors in the NTP study (Bernice Fisher and Hugh 

Pettigrew memo, 2/24/95). The cancer slope factor for ETU is also used for the EBDC 

compounds, mancozeb, metiram, and maneb which are metabolized to ETU (HED Document 

No. 013554, 7/7/99). 

Table 1. Summary of Toxicology Endpoint Selection for ETU 

Exposure 

Scenario 

Point of Departure/ 

Uncertainty and 

FQPA Safety 

Factors 

Level of Concern for 

Risk Assessment Study and Toxicological Effects 

Acute Dietary 

Females 13-50 years 

age

NOAEL = 5 

mg/kg/day 

UFA= 10x 

UFH=10x 

FQPA SF= 10x 

[Database 

Uncertainty Factor ] 

Acute RfD = 0.005 

mg/kg/day 

aPAD = 0.005 

mg/kg/day

Developmental rat study (Khera) 

LOAEL = 10 mg/kg/day based on 

developmental defects of brain. 

Acute Dietary

General Population

including 

infants/children 

NOAEL = N/A No appropriate endpoint from oral toxicity studies was identified. 

Chronic Dietary 

All populations

NOAEL = 0.18 

mg/kg/day 

UFA= 10x 

UFH=10x 

FQPA SF= 10x 

[Database 

Uncertainty Factor ] 

Chronic RfD = 0.0002 

mg/kg/day 

cPAD = 0.0002 

mg/kg/day

Dog chronic toxicity study. 

LOAEL = 1.99 mg/kg/day based on thyroid 

toxicity. 

Carcinogenicity Cancer slope factor = 

0.0601 (mg/kg/day)-1

B2 carcinogen with low-dose extrapolation for human risk assessment 

based on liver tumors in female mice. 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (intraspecies). UFH = potential variation in 

sensitivity among members of the human population (interspecies). UFDB = to account for the absence of key data 

(i.e., lack of a critical study). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = 

chronic). RfD = reference dose. N/A = not applicable. 
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VI. Results/Discussion

Exposure and risk estimates for the ETU aggregate cancer assessment are presented in Table 2. 

HED is generally concerned when the cancer risk is no longer considered negligible, generally 

when the risk exceeds 10-6. The results reported for food alone is 2.6 x 10-6and food and water is 

2.8 x 10-6. HED conducted a commodity contribution analysis (Attachment 12) to determine the 

commodities that contribute the greatest exposure. 

The crop groups contributing to the greatest exposure are listed in Table 3; the greatest 

contributor to the dietary exposure are the leafy vegetables. The commodity within the crop 

group leading to the most exposure is leaf lettuce (approximately 13% of the exposure). This 

assessment assumes that all leaf lettuce consumed in the US has been treated with an EBDC 

fungicide, either mancozeb or maneb. Other crop groups contributing more than 9% of the total 

exposure were the Brassica vegetables, fruiting vegetables and water. 

Table 2. Results of Cancer Dietary Exposure Analysis for ETU from Mancozeb, Maneb, and Metiram 

Population Subgroup Exposure 

(mg/kg/day) Estimated Cancer Risk 

General U.S. Population – Food Only 0.000043 2.6 x 10-6

General U.S. Population – Food and Water 0.000047 2.8 x 10-6

Table 3. Summary of Crop Groups Contributing Greater than 5% of Total Dietary Exposure 

Commodity Exposure, 

mg/kg bw/day 

Individual Cancer 

Risk 

Percent Contribution 

to Total Exposure 

Leafy Vegetables (except 

Brassica)1 0.0000093 5.6 x 10-7 20 

Brassica Vegetables 0.0000089 5.4 x 10-7 19 

Fruiting Vegetables 0.000054 3.3 x 10-7 12 

Water (direct and indirect 

sources) 0.0000044 2.7 x 10-7 9.4 

1

Note that this exposure value reflects the assumption that all lettuce consumed in the US has been treated with 

either mancozeb or maneb. 

VII. Characterization of Inputs/Outputs

The exposure assessments can be considered refined. Some inputs are conservative, while other 

inputs are highly refined. 

• Field trial data were used for all of the proposed new tolerances and several of the 

existing uses. These data are generally considered to be conservative as samples are 

taken directly from the field and do not reflect any residue reduction that may occur 

during packaging and shipping. They also reflect the maximum use rates on the product 

label; typical use rates may be lower. Monitoring data were used for several of the 

existing uses. 
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• Percent crop treated data were used for most of the existing uses of metiram, mancozeb, 

and maneb. However, percent crop treated information was not available for celery, 

ginseng, and the tropical fruits. 

• Percent crop treated information are not available for imported wine grapes, wine, and 

bananas. HED used percent imported data, so it was assumed that all bananas and wine 

grapes imported in the U.S. have been treated with metiram. It is unlikely that all of 

these imported commodities have been treated. 

• Percent crop treated – new (PCTn) data were used to refine the estimates for the proposed 

new uses of mancozeb. It is unlikely that actual PCT for mancozeb will exceed the 

estimated PCTn for mancozeb on each of these five crops during the next five years. 

• Consumer practice processing factors for procedures such as washing and cooking are 

available and were incorporated into the assessment, providing more refined exposure 

estimates. 

• Residue estimates were refined using factors reflecting commercial processing, such as 

wine production. 

• Estimates of residues in wine for the proposed import tolerance for metiram were 

determined by applying processing factors to grape field trial data. Monitoring studies 

for the other EBDC fungicides on domestic wine generally found much lower residues 

than the estimates used in this assessment. 

• Percent crop treated data for several commodities were not available, so it was assumed 

that all of these crops were treated. 

VIII. Conclusions

An aggregate cancer dietary risk assessment was conducted for the metabolite ethylene thiourea 

resulting from the existing uses of the EBDC fungicides, proposed new uses of mancozeb, and 

proposed new import tolerances for metiram. The aggregate (food and water) cancer risk 

estimate associated with exposure to ETU from all EBDCs for food and water is 2.8 x 10-6 for 

the general U.S. population, Although some inputs into this assessment are highly refined, other 

inputs are very conservative, as high-end field trial residues were used for some commodities, as 

well as the assumption of 100% crop treated for several commodities. The greatest contributors 

to the dietary exposure for the cancer assessment were leafy vegetables, Brassica vegetables, 

fruiting vegetables, and water. 

VIII. List of Attachments

Attachment 1: Estimation of Anticipated Residues for Proposed New Tolerances 

Attachment 2 Screening Level Usage Report for Mancozeb and Maneb 

Attachment 3: Screening Level Usage Analysis for Existing Uses of Metiram 

Attachment 4: Additional Percent Crop Treated Estimates for Maneb and Mancozeb 

Attachment 5: Projected Percent Crop Treated (PPCT) for the Fungicide Mancozcb on Lettuce 

(Head, and Other). 
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Attachment 6: BEAD Memo on Projected Percent Crop Treated (PPCT) with the Fungicide 

Mancozeb on Six New Crops: Almonds, Bell Pepper, Broccoli, Cabbage, 

Pumpkin, and Winter Squash, and Percent Import Share for Mandarin Oranges 

Attachment 7: BEAD Memo on Projected Percent Crop Treated for Mancozeb New Uses 

Percent Imported for Bananas and Grapes 

Attachment 8: BEAD Memo on Percent Crop Treated for New Uses (PCTn) of Mancozeb on 

Almonds, Broccoli, Cabbage, Pepper, Pumpkin, and Winter Squash and Percent 

Crop Treated with Maneb for Collards. Mustard Greens, Turnip Greens, and Kale 

Attachment 9. Residue Input File – ETU Cancer Analysis – Food and Water 

Attachment 10. Results File – ETU Aggregate Cancer Food Only 

Attachment 11. Results File – ETU Aggregate Cancer Food and Water 

Attachment 12. Results File – ETU Aggregate Cancer Food and Water – Critical Commodity 

Contribution Analysis 
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Attachment 1: Estimation of Anticipated Residues for Proposed New Tolerances 

Crop field trial data were used to estimate anticipated residues for the proposed new tolerances 

for metiram on imported bananas and grapes, and the proposed new uses of mancozeb on 

almonds, broccoli, cabbage, lettuce, and peppers. A detailed discussion of the residue data used 

may be found in the residue chemistry summary documents (C. Olinger, DP Barcodes D289183, 

4/3/07; C. Olinger, D311550 and D321530, 4/24/07; C. Olinger, DP Number 294203, 4/3/07). 

Processing factors for grape processed products were derived from processing studies submitted 

in association with the petition. Additionally, processing factors for consumer practices such as 

washing and cooking were used (Reregistration of Mancozeb, Maneb, and Metiram: Processing 

and Cooking Factors to be Used in the Dietary Risk Assessment”, C. Olinger, 11/5/2003, DP 

Barcodes D289569; D289570; D289571). A discussion of the anticipated residues for the 

proposed new tolerances for metiram and mancozeb may be found in the dietary assessments for 

the individual chemicals (C. Olinger, DP Barcode D326753, 4/17/07; and C. Olinger, D323878 

and D323879, 4/17/07). 

Calculation of Residue Estimates

Ethylene thiourea (ETU) residues in/on raw agricultural commodities (RAC) were adjusted for 

processing factors. In addition, approximately 7.5% of the EBDC consumed converts to ETU in 

the body; this metabolic ETU must be considered when estimating ETU exposure through food. 

Total ETU residues in foods consist of ETU in the raw or processed commodities plus the 

metabolic ETU from parent EBDC. EBDCs may also be converted to ETU during processing, 

usually when the process involves heating. Below are the formulas used to calculate ETU 

residue estimates, including both conversion during processing as well as the metabolic ETU: 

Raw Agricultural Commodities: 

 [ETU]AR = [ETU]RAC + ([EBDC]RAC X 0.075 X PF1) 

 where 

 [ETU]AR = ETU anticipated residue estimate 

 [ETU]RAC = ETU concentration as measured in the RAC 

 [EBDC]RAC = EBDC concentration as measured in the RAC 

 0.075 = metabolic conversion factor 

 PF1 = consumer processing factor (such as peeling, washing, trimming) 

Processed Commodities: 

 [ETU]AR = ([ETU]RAC X PF2) + ([EBDC]RAC X 0.075 X PF3) + ([EBDC]RAC X 

CF) 

 where 

 [ETU]AR = ETU anticipated residue estimate 

 [ETU]RAC = ETU concentration as measured in the RAC 

 PF2 = ETU processing factor (e.g. cooking) 

 [EBDC]RAC = EBDC concentration as measured in the RAC 

 0.075 = metabolic conversion factor 

 PF3 = processing factor (such as peeling, washing, trimming, cooking) 

 CF = conversion factor for conversion of EBDC to ETU 
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Sample Calculation:

Given a raw cucumber sample bearing EBDC residues of 0.17 ppm and ETU residues of 0.02 ppm;

EBDC Cooking Factor is 0.0114, ETU cooking factor is 0.87, EBDC to ETU Conversion Factor is 5.3%,

and the in vivo metabolic conversion factor is 7.5 %.

EBDC Residues in Cooked Cucumber:

[EBDC]raw x CF = [EBDC]cooked

0.17 ppm x 0.114 = 0.005 ppm

Total ETU Residues in Cooked Cucumber

[ETU]AR = ([ETU]RAC X PF2) + ([EBDC]RAC X 0.075 X PF3) + ([EBDC]RAC X CF)

Loss of ETU Residues from Cooking

([ETU]RAC X PF2)

0.02 ppm * 0.87 = 0.017 ppm

In vivo Conversion of EBDC residues in cooked commodity to ETU

([EBDC]RAC X 0.075 X PF3)

0.17 ppm * 0.075 * 0.0114 = 0.00014

Conversion of Raw EBDC residues in Raw commodity to ETU during cooking

[EBDC]RAC X CF

0.17 ppm * 0.053 = 0.0089

Total ETU Residues = 0.017 + 0.00014 + 0.0089 = 0.026 ppm

Aggregate Usage Data

The general approach to combining usage information for the aggregate assessment can be found 

in the document, Ethylene bisdithiocarbamates [Mancozeb, Maneb, and Metiram]. Summary of 

Percent Crop Treated (%CT), and Justification for Use of the 1990 EBDC Market Basket Survey 

in Dietary Exposure Assessments for Reregistration (Barcode Nos. D290139, D290140, and 

D290137, 9/4/03, C. Swartz). It is assumed that a given crop will not be treated with more than 

one EBDC fungicide, and the percent crop treated values are added to give the aggregate percent 

crop treated. However, for a few crops the percent crop treated, projected percent crop treated, 

and/or percent imported values add up to more than 100% aggregate percent crop treated. In 

such cases, the percent crop treated for the EBDC(s) showing the lowest residues were adjusted 

downward, or even assumed to be zero, until an aggregate percent crop treated was 100%. This 

adjustment may give a more conservative estimation of risk, but will ensure that the risk is not 

underestimated. 

Summary Table

The table on the following pages provide a summary of the anticipated residues used in the 

dietary exposure assessment.
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Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment 1 

Commodity 

Residue 

Data 

Source 2 

Average 

Mancozeb 

Residue, 

ppm 

Percent 

CT 

Mancozeb 

Residue 

Data 

Source 2

Average 

Maneb 

Residue, 

ppm 

Percent 

CT 

Maneb 

Residue 

Data 

Source 2

Average 

Metiram 

Residue, 

ppm 

Pe

M

Almond FT 0.00688 18 FT 0.007 10 Almond Cooked FT 0.00573 18 FT 0.00613 10 Apple FT 0.00562 35 FT 0.0658 1 FT 0.01 Apple, Cooked FT 0.0026 35 FT 0.065 1 FT 0.0037 Apple Dried FT 0.0033 35 FT 0.066 1 FT 0.01 Apple Dried Cooked FT 0.0022 35 FT 0.057 1 FT 0.0037 Apple Juice FT 0.003 35 FT 0.067 1 FT 0.0049 Apple Juice Cooked FT 0.0022 35 FT 0.077 1 FT 0.0038 Apple Sauce FT 0.0027 35 FT 0.0658 1 FT 0.01 Apple Sauce Cooked FT 0.0027 35 FT 0.065 1 FT 0.0037 Asparagus FT 0.006 15 Asparagus Cooked FT 0.086 15 Banana FT 0.0033 85 0.0033 0 FT 0.009488 Banana Cooked FT 0.0022 85 0.0022 0 FT 0.005828 Banana Dried FT 0.0033 85 0.0033 0 FT 0.007215 Banana Dried Cooked FT 0.0022 85 0.0022 0 FT 0.005606 Barley, Pearled Barley FT 0.005 1 FT 0.00491 Barley Flour FT 0.185 1 FT 0.0189 Barley Flour Cooked FT 0.0055 1 FT 0.00571 Barley Bran FT 0.0085 1 FT 0.00548 
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Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment 1 

Commodity 

Residue 

Data 

Source 2 

Average 

Mancozeb 

Residue, 

ppm 

Percent 

CT 

Mancozeb 

Residue 

Data 

Source 2

Average 

Maneb 

Residue, 

ppm 

Percent 

CT 

Maneb 

Residue 

Data 

Source 2

Average 

Metiram 

Residue, 

ppm 

Pe

M

Bean Dried FT MBS 0.00257 1 Beets, Sugar FT 0.0042 2.5 FT 0.000688 1 Belgium Endive FT FT 0.58 100 Broccoli FT 0.118 5 MBS 0.00457 10 Broccoli, Cooked FT 0.0517 5 MBS 0.00283 10 Brussels Sprouts FT MBS 0.00457 15 Brussels Sprouts Cooked FT MBS 0.00283 15 Cabbage FT 0.061 42 MBS 0.00274 20 Cabbage Cooked FT 0.102 42 MBS 0.00244 20 Cabbage, Chinese FT 0.191 42 MBS 0.58 20 Cabbage, Chinese, Cooked 

FT 0.544 42 MBS 0.98 20 

Canistel FT 0.19 100 MBS Cantaloupe FT 0.092 5 MBS 0.00632 2.5 Cantaloupe, Cooked FT 0.06 5 MBS 0.013 2.5 Carrot FT 0.0078 5 Carrot Cooked FT 0.0125 5 Carrot Juice FT 0.0078 5 Carrot Juice Cooked FT 0.0066 5 Casaba FT 0.0091 5 FT 0.00632 95 
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Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment 1 

Commodity 

Residue 

Data 

Source 2 

Average 

Mancozeb 

Residue, 

ppm 

Percent 

CT 

Mancozeb 

Residue 

Data 

Source 2

Average 

Maneb 

Residue, 

ppm 

Percent 

CT 

Maneb 

Residue 

Data 

Source 2

Average 

Metiram 

Residue, 

ppm 

Pe

M

Cauliflower MBS 0.00457 10 Cauliflower, Cooked MBS 0.00283 10 Celery FT 0.0075 100 Celery Cooked FT 0.0043 100 Celery, Juice FT 0.0054 100 Celery Juice Cooked FT 0.0046 100 Cherimoya FT 0.0196 100 Chickpea MBS 0.00257 1 Chinese Waxgourd MBS 0.013 100 Chive FT 0.00337 100 Chive, Cooked FT 0.00292 100 Collards FT 0.324 31 Corn, Field, Flour MBS 0.014 1 Corn, Field Flour, Cooked MBS 0.0066 1 Corn, Field, Meal MBS 0.0065 1 Corn, Field, Bran MBS 0.0084 1 Corn Field Bran Cooked MBS 0.0066 1 Corn Field, Starch MBS 0.0015 1 
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Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment 1 

Commodity 

Residue 

Data 

Source 2 

Average 

Mancozeb 

Residue, 

ppm 

Percent 

CT 

Mancozeb 

Residue 

Data 

Source 2

Average 

Maneb 

Residue, 

ppm 

Percent 

CT 

Maneb 

Residue 

Data 

Source 2

Average 

Metiram 

Residue, 

ppm 

Pe

M

Corn Field Starch, Cooked MBS 0.0014 1 Corn, Field Syrup MBS 0.0076 1 Corn, Field, Syrup Cooked MBS 0.0061 1 Corn, Field, Oil MBS 0.0043 1 Corn, Pop MBS 0.0034 100 Corn, Sweet MBS 0.00077 5 MBS 0.00408 1 Corn, Sweet Cooked MBS 0.0004 5 MBS 0.0028 1 Cottonseed, Oil FT 0.0012 1 FT 0.00175 10 Crabapple FT 0.012 100 FT 0.065 0 Cranberry FT 0.096 40 FT 0.11 5 Cranberry Cooked FT 0.044 40 FT 0.0153 5 Cranberry Dried FT 0.16 40 FT 0.11 5 Cranberry Dried Cooked FT 0.064 40 FT 0.0153 5 Cranberry Juice FT 0.053 40 FT 0.11 5 Cranberry Juice Cooked FT 0.04 40 FT 0.0146 5 Cucumber MBS 0.0052 20 MBS 0.00632 10 Cucumber Cooked MBS 0.0052 20 MBS 0.013 10 Eggplant MBS 0.00552 30 Eggplant Cooked MBS 0.00451 30 
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Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment 1 

Commodity 

Residue 

Data 

Source 2 

Average 

Mancozeb 

Residue, 

ppm 

Percent 

CT 

Mancozeb 

Residue 

Data 

Source 2

Average 

Maneb 

Residue, 

ppm 

Percent 

CT 

Maneb 

Residue 

Data 

Source 2

Average 

Metiram 

Residue, 

ppm 

Pe

M

Endive 0.58 100 Endive Cooked 0.98 100 Fennel, Florence FT 0.0075 100 Fig FT 1.46 5 Fig Cooked FT 1.27 5 Fig, Dried FT 1.43 5 Fig Dried Cooked FT 1.3 5 Flaxseed Oil FT 0.0055 1 FT 0.00332 10 Garlic MBS 0.00337 25 Garlic Cooked MBS 0.00292 25 Garlic Dried MBS 0.00376 25 Garlic Dried Cooked MBS 0.00292 25 Ginseng, Dried FT 0.052 100 Grape FT 0.0153 5 FT 0.0212 1 FT 0.0352 Grape Cooked FT 0.00867 5 FT 0.02 1 FT 0.0262 Grape Juice FT 0.0004 5 FT 0.0059 1 FT 0.0327 Grape Juice Cooked FT 0.0015 5 FT 0.0025 1 FT 0.0189 Grape Leaves FT 0.0153 5 FT 0.98 1 FT 0.0262 Grape Raisin FT 0.0227 5 FT 0.0267 1 FT 0.069 Grape Raisin Cooked FT 0.01133 5 FT 0.0254 1 FT 0.0211 Grape Wine MON 0.0087 5 MON 0.0087 1 FT 0.0327 
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Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment 1 

Commodity 

Residue 

Data 

Source 2 

Average 

Mancozeb 

Residue, 

ppm 

Percent 

CT 

Mancozeb 

Residue 

Data 

Source 2

Average 

Maneb 

Residue, 

ppm 

Percent 

CT 

Maneb 

Residue 

Data 

Source 2

Average 

Metiram 

Residue, 

ppm 

Pe

M

Grape Wine Cooked MON 0.007 5 MON 0.007 1 FT 0.0189 Guar, Seed FT 0.00358 1 Guar, Seed Cooked FT 0.00257 1 Honeydew Melon FT 0.092 5 FT 0.00632 95 Kale FT 0.324 73 Kohlrabi MBS 0.00283 100 Leek FT 0.00337 15 Leek Cooked FT 0.00292 15 Lettuce, Head FT 0.00842 67 MBS 0.00268 33 Lettuce Head Cooked FT 0.0163 67 MBS 0.00238 33 Lettuce Leaf FT 0.191 35 FT 0.58 65 Mango FT 0.19 100 Mango Cooked FT 0.1 100 Mango Juice FT 0.12 100 Mango Juice Cooked FT 0.098 100 Mustard Greens FT 0.56 22 Oat Bran FT 0.03 1 FT 0.03 10 Oat Bran Cooked FT 0.0085 1 FT 0.0085 10 Oat Flour FT 0.0082 1 FT 0.0082 10 Oat, Groats FT 0.0081 1 FT 0.0081 10 
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Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment 1 

Commodity 

Residue 

Data 

Source 2 

Average 

Mancozeb 

Residue, 

ppm 

Percent 

CT 

Mancozeb 

Residue 

Data 

Source 2

Average 

Maneb 

Residue, 

ppm 

Percent 

CT 

Maneb 

Residue 

Data 

Source 2

Average 

Metiram 

Residue, 

ppm 

Pe

M

Oat, Groats Cooked FT 0.0081 1 FT 0.0081 10 Onion, Dry Bulb MBS 0.0031 60 MBS 0.00337 15 Onion, Dry Bulb Cooked MBS 0.0026 60 MBS 0.00292 15 Onion Dry Bulb, Dried MBS 0.0027 60 MBS 0.00337 15 Onion Dry Bulb, Dried Cooked MBS 0.0026 60 MBS 0.00292 15 Onion, Green MBS 0.0031 60 MBS 0.00337 15 Onion Green Cooked MBS 0.0026 60 MBS 0.00292 15 Papaya FT 0.19 100 0.113 0 Papaya Cooked FT 0.1 100 0.102 0 Papaya, Dried FT 0.13 100 0.133 0 Papaya, Juice FT 0.12 100 0.12 0 Papaya Juice Cooked FT 0.098 100 0.113 0 Peanut FT 0.0058 1 FT 0.00688 1 Peanut Cooked FT 0.011 1 FT 0.0051 1 Peanut, Butter FT 0.0058 1 FT 0.00688 1 Peanut, Butter, Cooked FT 0.011 1 FT 0.0051 1 Peanut, Oil FT 0.0013 1 FT 0.00556 1 Pear FT 0.012 35 Pear Cooked FT 0.0053 35 Pear Dried FT 0.0069 35 
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Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment 1 

Commodity 

Residue 

Data 

Source 2 

Average 

Mancozeb 

Residue, 

ppm 

Percent 

CT 

Mancozeb 

Residue 

Data 

Source 2

Average 

Maneb 

Residue, 

ppm 

Percent 

CT 

Maneb 

Residue 

Data 

Source 2

Average 

Metiram 

Residue, 

ppm 

Pe

M

Pear Dried Cooked FT 0.0044 35 Pepper, Bell FT 0.142 44 MBS 0.00552 30 Pepper, Bell Cooked FT 0.128 44 MBS 0.00451 30 Pepper Bell Dried FT 0.00953 44 MBS 0.00353 30 Pepper Bell Dried Cooked FT 0.068 44 MBS 0.00447 30 Pepper Nonbell FT 0.149 44 MBS 0.00552 30 Pepper Nonbell Cooked FT 0.244 44 MBS 0.00451 30 Pepper Nonbell Dried FT 0.067 44 MBS 0.00353 30 Pepper Nonbell Dried Cooked FT 0.054 44 MBS 0.00447 30 Plantain FT 0.0313 100 0.0148 0 Plantain Cooked FT 0.0236 100 0.005 0 Plantain Dried FT 0.0236 100 0.00135 0 Potato Chips MBS 0.00305 55 MBS 0.00305 2.5 FT 0.01 Potato Dry MBS 0.00237 55 MBS 0.00237 2.5 FT 0.0087 Potato Flour MBS 0.00428 55 MBS 0.00428 2.5 FT 0.01 Potato Flour Cooked MBS 0.00237 55 MBS 0.00237 2.5 FT 0.0087 Potato Tuber W/peel MBS 0.00232 55 MBS 0.00232 2.5 FT 0.0033 Potato Tuber MBS 0.00267 55 MBS 0.00271 2.5 FT 0.0027 
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Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment 1 

Commodity 

Residue 

Data 

Source 2 

Average 

Mancozeb 

Residue, 

ppm 

Percent 

CT 

Mancozeb 

Residue 

Data 

Source 2

Average 

Maneb 

Residue, 

ppm 

Percent 

CT 

Maneb 

Residue 

Data 

Source 2

Average 

Metiram 

Residue, 

ppm 

Pe

M

W/o Peel Potato, Tuber, W/o Peel Cooked 

MBS 0.00267 55 MBS 0.00267 2.5 0.0033 

Pumpkin MBS 0.0092 45 MBS 0.013 2.5 Pumpkin Seed MBS 0.0092 45 MBS 0.00365 2.5 Pumpkin Seed Cooked MBS 0.06 45 MBS 0.00257 2.5 Quince FT 0.012 100 Rice FT 0.024 1 Rice Cooked FT 0.016 1 Rice Flour FT 0.025 1 Rice Flour Cooked FT 0.017 1 Rice Bran FT 0.031 1 Rice Bran Cooked FT 0.016 1 Rye Grain FT 0.0081 1 FT 0.00491 10 Rye Flour FT 0.0081 1 FT 0.0189 10 Safflower, Oil FT 0.0055 1 FT 0.00332 10 Sapote, Mamey FT 0.19 100 FT Shallot MBS 0.00337 15 Sorghum Grain FT 0.024 100 Sorghum Syrup FT 0.016 100 Soursop FT 0.0196 100 Squash, Summer MBS 0.0052 47 MBS 0.00632 10 
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Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment 1 

Commodity 

Residue 

Data 

Source 2 

Average 

Mancozeb 

Residue, 

ppm 

Percent 

CT 

Mancozeb 

Residue 

Data 

Source 2

Average 

Maneb 

Residue, 

ppm 

Percent 

CT 

Maneb 

Residue 

Data 

Source 2

Average 

Metiram 

Residue, 

ppm 

Pe

M

Squash, Summer Cooked 

MBS 0.0052 47 MBS 0.013 10 

Squash, Winter MBS 0.0092 47 MBS 0.013 10 Sugar Apple FT 0.0196 100 FT Tomato MBS 0.00714 25 MBS 0.0076 5 Tomato Cooked MBS 0.0078 25 MBS 0.0069 5 Tomato Paste MBS 0.00779 25 MBS 0.00779 5 Tomato Paste Cooked MBS 0.00664 25 MBS 0.00664 5 Tomato Puree MBS 0.00454 25 MBS 0.00454 5 Tomato Puree Cooked MBS 0.00389 25 MBS 0.00389 5 Tomato Dried MBS 0.00353 25 MBS 0.0066 5 Tomato Dried Cooked MBS 0.00447 25 MBS 0.0066 5 Tomato Juice MBS 0.00257 25 MBS 0.00257 5 Tomato Juice, Cooked MBS 0.00218 25 MBS 0.00218 5 Turnip Tops FT 0.56 36 Walnut FT 0.0059 1 FT 0.0059 35 Walnut Cooked FT 0.0059 1 FT 0.0062 35 Watermelon FT 0.0091 40 FT 0.00632 5 Watermelon Juice FT 0.0091 40 FT 0.00632 5 Wheat, Grain FT 0.016 1 FT 0.0176 10 
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Table I-1. Summary of Chronic Anticipated Residues for ETU Aggregate Assessment 1 

Commodity 

Residue 

Data 

Source 2 

Average 

Mancozeb 

Residue, 

ppm 

Percent 

CT 

Mancozeb 

Residue 

Data 

Source 2

Average 

Maneb 

Residue, 

ppm 

Percent 

CT 

Maneb 

Residue 

Data 

Source 2

Average 

Metiram 

Residue, 

ppm 

Pe

M

Wheat, Grain Cooked FT 0.0073 1 FT 0.00491 10 Wheat, Flour FT 0.017 1 FT 0.0189 10 Wheat Flour Cooked FT 0.0073 1 FT 0.00571 10 Wheat, Germ FT 0.0076 1 FT 0.00548 10 Wheat Bran FT 0.027 1 FT 0.0302 10 Wheat Bran Cooked FT 0.0076 1 FT 0.00548 10 Meat 4 MBS 0.000585 55 0.000585 0 Meat, Cooked 4 MBS 0.000497 55 0.000497 0 Milk 4 MBS 0.000595 55 0.000595 0 Milk Cooked 4 MBS 0.000464 55 0.000464 0 

1 Usage information was obtained from the six memos attached to this memorandum as Attachments 2- 7. 2 FT = field trial data; MBS = Market Basket Survey Data; MON = Grape Juice and Wine Monitoring data. 3 For commodities that the total percent crop treated of all three fungicides exceeds 100%, the PCT values were 

sum would not exceed 100%. 

4 For meat and milk the highest percent crop treated for a single livestock feed +commodity was used. 
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Attachment 2 Screening Level Usage Report for Mancozeb and Maneb 
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Attachment 3: Screening Level Usage Analysis for Existing Uses of Metiram 

Tuesday, March 22, 2005 

Screening Level Estimates of Agricultural Uses of Metiram 

Sorted Alphabetically 

 

Crop Lbs. A.I. Percent Crop Ttd. 

 Avg. Max. 

1 Apples 500,000 15 25 

2 Asparagus 1,000 <1 <2.5 

3 Peaches 2,000 <1 <2.5 

4 Pears <500 <1 <2.5 

5 Potatoes 400,000 10 10 

6 Squash <500 <1 <2.5 
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Attachment 4: Additional Percent Crop Treated Estimates for Maneb and Mancozeb 
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Attachment 5: Projected Percent Crop Treated (PPCT) for the Fungicide Mancozeb on Lettuce 

(Head, and Other). 
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Attachment 6: BEAD Memo on Projected Percent Crop Treated (PPCT) with the Fungicide 

Mancozeb on Six New Crops: Almonds, Bell Pepper, Broccoli, Cabbage, Pumpkin, and Winter 

Squash, and Percent Import Share for Mandarin Oranges 
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Attachment 7: BEAD Memo on Projected Percent Crop Treated for Mancozeb New Uses Percent 

Imported for Bananas and Grapes 
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Attachment 8: BEAD Memo on Percent Crop Treated for New Uses (PCTn) of Mancozeb on 

Almonds, Broccoli, Cabbage, Pepper, Pumpkin, and Winter Squash and Percent 

Crop Treated with Maneb for Collards. Mustard Greens, Turnip Greens, and Kale

 
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Attachment 9: Residue Input File – ETU Cancer Analysis – Food and Water 

Filename: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Dietary2009\ETUAggregate2009\aggregateETUchronicpria2009foodandwater_10_18_10_new_leafy

brassicas_metiram wine grapes onlyceleryincluded.R98 

Chemical: ETU - Aggregate - Chronic 

RfD(Chronic): .0002 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day 

RfD(Acute): .005 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0601 

Date created/last modified: 10-18-2010/09:45:13/8 Program ver. 2.03 

Comment: celery included; Use 9/16/10 pct for leafy brassicas and other new uses; metiram 

wine grapes only 

-------------------------------------------------------------------------------- 

RDL indices and parameters for Monte Carlo Analysis: 

Index Dist Parameter #1 Param #2 Param #3 Comment 

 # Code 

----- ---- ------------ -------- -------- ------- 

 1 6 ETUapples.rdf 

 2 6 ETUpotato.rdf 

Note: No residue distributions have been assigned to Commodities/FoodForms below 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ ------- 

14000030 14 Almond 

14000031 14 Almond-babyfood 0.001640 1.000 1.000 Last e 

 Full comment: Last edited 7/30/10 

14000040 14 Almond, oil 0.001640 1.000 1.000 Last e 

 Full comment: Last edited 7/30/10 

14000041 14 Almond, oil-babyfood 0.001640 1.000 1.000 Last e 

 Full comment: Last edited 7/30/10 

11000070 11 Apple, fruit with peel 

11000080 11 Apple, peeled fruit 

11000081 11 Apple, peeled fruit-babyfood 0.002120 1.000 1.000 Last e 

 Full comment: Last edited 6/9/09 

11000090 11 Apple, dried 

11000091 11 Apple, dried-babyfood 

11000100 11 Apple, juice 

11000101 11 Apple, juice-babyfood 

11000110 11 Apple, sauce 

11000111 11 Apple, sauce-babyfood 0.002150 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

95000190 O Asparagus 

95000230 O Banana 

95000231 O Banana-babyfood 

95000240 O Banana, dried 

95000241 O Banana, dried-babyfood 

15000250 15 Barley, pearled barley 0.000050 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

15000251 15 Barley, pearled barley-babyfood 0.000050 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

15000260 15 Barley, flour 

15000261 15 Barley, flour-babyfood 

15000270 15 Barley, bran 0.000085 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06030300 6C Bean, black, seed 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06030320 6C Bean, broad, seed 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06030340 6C Bean, cowpea, seed 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06030350 6C Bean, great northern, seed 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 
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06030360 6C Bean, kidney, seed 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06030380 6C Bean, lima, seed 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06030390 6C Bean, mung, seed 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06030400 6C Bean, navy, seed 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06030410 6C Bean, pink, seed 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06030420 6C Bean, pinto, seed 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

21000440 M Beef, meat 

21000441 M Beef, meat-babyfood 

21000450 M Beef, meat, dried 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

21000460 M Beef, meat byproducts 

21000461 M Beef, meat byproducts-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

21000470 M Beef, fat 

21000471 M Beef,fat-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

21000480 M Beef, kidney 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

21000490 M Beef, liver 

21000491 M Beef, liver-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

01010520 1A Beet, sugar 0.000112 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

01010521 1A Beet, sugar-babyfood 0.000112 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

01010530 1A Beet, sugar, molasses 0.000112 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

01010531 1A Beet, sugar, molasses-babyfood 0.000112 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

95000540 O Belgium endive 0.580000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

05010610 5A Broccoli 

05010611 5A Broccoli-babyfood 0.002870 1.000 1.000 Last e 

 Full comment: Last edited 10/18/10 

05010640 5A Brussels sprouts 

05010690 5A Cabbage 

05020700 5B Cabbage, Chinese, bok choy 

05010710 5A Cabbage, Chinese, napa 

05010720 5A Cabbage, Chinese, mustard 

95000740 O Canistel 0.190000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

09010750 9A Cantaloupe 

01010780 1AB Carrot 

01010781 1AB Carrot-babyfood 

01010790 1AB Carrot, juice 

09010800 9A Casaba 0.006460 1.000 1.000 Last e 

 Full comment: Last edited 6/12/09 

05010830 5A Cauliflower 

04020850 4B Celery 

04020851 4B Celery-babyfood 

04020860 4B Celery, juice 

95000890 O Cherimoya 0.019600 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

40000930 P Chicken, meat 

40000931 P Chicken, meat-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

40000940 P Chicken, liver 0.000270 1.000 1.000 Last e 
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 Full comment: Last edited 5/1/09 

40000950 P Chicken, meat byproducts 

40000951 P Chicken, meat byproducts-babyfoo 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

40000960 P Chicken, fat 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

40000961 P Chicken, fat-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

40000970 P Chicken, skin 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

40000971 P Chicken, skin-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06030980 6C Chickpea, seed 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06030981 6C Chickpea, seed-babyfood 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06030990 6C Chickpea, flour 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

09021020 9B Chinese waxgourd 0.013000 1.000 1.000 Last e 

 Full comment: Last edited 6/9/09 

19011030 19A Chive 

05021170 5B Collards 0.100000 1.000 1.000 Last e 

 Full comment: Last edited 10/18/10 

15001200 15 Corn, field, flour 

15001201 15 Corn, field, flour-babyfood 

15001210 15 Corn, field, meal 0.000065 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

15001211 15 Corn, field, meal-babyfood 0.000065 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

15001220 15 Corn, field, bran 

15001230 15 Corn, field, starch 

15001231 15 Corn, field, starch-babyfood 

15001240 15 Corn, field, syrup 

15001241 15 Corn, field, syrup-babyfood 

15001250 15 Corn, field, oil 0.000043 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

15001251 15 Corn, field, oil-babyfood 0.000043 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

15001260 15 Corn, pop 0.003400 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

15001270 15 Corn, sweet 

15001271 15 Corn, sweet-babyfood 0.000048 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

95001280 O Cottonseed, oil 0.000187 1.000 1.000 Last e 

 Full comment: Last edited 6/9/09 

95001281 O Cottonseed, oil-babyfood 0.000187 1.000 1.000 Last e 

 Full comment: Last edited 6/9/09 

11001290 11 Crabapple 0.012000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

95001300 O Cranberry 

95001301 O Cranberry-babyfood 0.018400 1.000 1.000 Last e 

 Full comment: Last edited 6/9/09 

95001310 O Cranberry, dried 

95001320 O Cranberry, juice 

95001321 O Cranberry, juice-babyfood 0.016700 1.000 1.000 Last e 

 Full comment: Last edited 6/9/09 

09021350 9B Cucumber 

70001450 P Egg, whole 

70001451 P Egg, whole-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

70001460 P Egg, white 

70001461 P Egg, white (solids)-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 
Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

PC Code: 600016 

Page 59 of 71 

70001470 P Egg, yolk 

70001471 P Egg, yolk-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

08001480 8 Eggplant 

04011500 4A Endive 

04021520 4B Fennel, Florence 0.007500 1.000 1.000 Last e 

 Full comment: Last edited 10/18/10 

95001530 O Fig 

95001540 O Fig, dried 

20001630 20 Flaxseed, oil 0.000387 1.000 1.000 Last e 

 Full comment: Last edited 6/9/09 

03001640 3 Garlic 

03001650 3 Garlic, dried 

03001651 3 Garlic, dried-babyfood 0.000730 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

01011680 1AB Ginseng, dried 0.052000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

23001690 M Goat, meat 0.000270 1.000 1.000 

23001700 M Goat, meat byproducts 0.000270 1.000 1.000 

23001710 M Goat, fat 0.000270 1.000 1.000 

23001720 M Goat, kidney 0.000270 1.000 1.000 

23001730 M Goat, liver 0.000270 1.000 1.000 

95001750 O Grape 

95001760 O Grape, juice 

95001761 O Grape, juice-babyfood 0.000100 1.000 1.000 Last e 

 Full comment: Last edited 7/30/10 

95001770 O Grape, leaves 0.010600 1.000 1.000 Last e 

 Full comment: Last edited 7/30/10 

95001780 O Grape, raisin 

95001790 O Grape, wine and sherry 

06031820 6C Guar, seed 

09011870 9A Honeydew melon 0.010600 1.000 1.000 Last e 

 Full comment: Last edited 6/10/09 

05021940 5B Kale 0.237000 1.000 1.000 Last e 

 Full comment: Last edited 7/30/10 

05011960 5A Kohlrabi 0.002830 1.000 1.000 Last e 

 Full comment: Last edited 6/10/09 

03001980 3 Leek 

06032030 6C Lentil, seed 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

04012040 4A Lettuce, head 

04012050 4A Lettuce, leaf 0.444000 1.000 1.000 Last e 

 Full comment: Last edited 7/30/10 

95002150 O Mango 

95002151 O Mango-babyfood 0.100000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

95002160 O Mango, dried 0.100000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

95002170 O Mango, juice 

95002171 O Mango, juice-babyfood 0.098000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

27002220 D Milk, fat 

27002221 D Milk, fat - baby food/infant for 0.000260 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

27012230 D Milk, nonfat solids 0.000260 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

27012231 D Milk, nonfat solids-baby food/in 

27022240 D Milk, water 0.000260 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

27022241 D Milk, water-babyfood/infant form 0.000260 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

27032251 D Milk, sugar (lactose)-baby food/ 0.000260 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 
Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

PC Code: 600016 

Page 60 of 71 

05022290 5B Mustard greens 0.123000 1.000 1.000 Last e 

 Full comment: Last edited 7/30/10 

15002310 15 Oat, bran 

15002320 15 Oat, flour 

15002321 15 Oat, flour-babyfood 0.000902 1.000 1.000 Last e 

 Full comment: Last edited 6/10/09 

15002330 15 Oat, groats/rolled oats 

15002331 15 Oat, groats/rolled oats-babyfood 0.000891 1.000 1.000 Last e 

 Full comment: Last edited 6/10/09 

03002370 3 Onion, dry bulb 

03002371 3 Onion, dry bulb-babyfood 0.002000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

03002380 3 Onion, dry bulb, dried 

03002381 3 Onion, dry bulb, dried-babyfood 

03002390 3 Onion, green 

95002450 O Papaya 

95002451 O Papaya-babyfood 0.100000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

95002460 O Papaya, dried 0.130000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

95002470 O Papaya, juice 

06032560 6C Pea, dry 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06032561 6C Pea, dry-babyfood 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

06032580 6C Pea, pigeon, seed 0.000026 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

95002630 O Peanut 

95002640 O Peanut, butter 

95002650 O Peanut, oil 0.000070 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

11002660 11 Pear 

11002661 11 Pear-babyfood 0.001860 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

11002670 11 Pear, dried 

11002680 11 Pear, juice 

11002681 11 Pear, juice-babyfood 0.002100 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

08002700 8 Pepper, bell 

08002701 8 Pepper, bell-babyfood 0.057700 1.000 1.000 Last e 

 Full comment: Last edited 10/18/10 

08002710 8 Pepper, bell, dried 

08002711 8 Pepper, bell, dried-babyfood 0.031300 1.000 1.000 Last e 

 Full comment: Last edited 10/18/10 

08002720 8 Pepper, nonbell 

08002721 8 Pepper, nonbell-babyfood 0.109000 1.000 1.000 Last e 

 Full comment: Last edited 10/18/10 

08002730 8 Pepper, nonbell, dried 

95002830 O Plantain 

95002840 O Plantain, dried 0.023600 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

25002900 M Pork, meat 

25002901 M Pork, meat-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

25002910 M Pork, skin 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

25002920 M Pork, meat byproducts 

25002921 M Pork, meat byproducts-babyfood 0.001000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

25002930 M Pork, fat 

25002931 M Pork, fat-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

25002940 M Pork, kidney 0.000270 1.000 1.000 Last e 
Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

PC Code: 600016 

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 Full comment: Last edited 5/1/09 

25002950 M Pork, liver 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

01032960 1C Potato, chips 0.002750 1.000 1.000 Last e 

 Full comment: Last edited 6/10/09 

01032970 1C Potato, dry (granules/ flakes) 0.002230 1.000 1.000 Last e 

 Full comment: Last edited 6/10/09 

01032971 1C Potato, dry (granules/ flakes)-b 0.002230 1.000 1.000 Last e 

 Full comment: Last edited 6/10/09 

01032980 1C Potato, flour 

01032981 1C Potato, flour-babyfood 

01032990 1C Potato, tuber, w/peel 0.001660 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

01032991 1C Potato, tuber, w/peel-babyfood 0.001660 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

01033000 1C Potato, tuber, w/o peel 

01033001 1C Potato, tuber, w/o peel-babyfood 0.001870 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

60003010 P Poultry, other, meat 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

60003020 P Poultry, other, liver 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

60003030 P Poultry, other, meat byproducts 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

60003040 P Poultry, other, fat 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

60003050 P Poultry, other, skin 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

09023080 9B Pumpkin 0.004460 1.000 1.000 Last e 

 Full comment: Last edited 10/18/10 

09023090 9B Pumpkin, seed 

11003100 11 Quince 0.012000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

15003230 15 Rice, white 

15003231 15 Rice, white-babyfood 0.000160 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

15003240 15 Rice, brown 

15003241 15 Rice, brown-babyfood 

15003250 15 Rice, flour 

15003251 15 Rice, flour-babyfood 

15003260 15 Rice, bran 

15003261 15 Rice, bran-babyfood 0.000160 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

15003280 15 Rye, grain 0.000572 1.000 1.000 Last e 

 Full comment: Last edited 6/10/09 

15003290 15 Rye, flour 0.001970 1.000 1.000 Last e 

 Full comment: Last edited 6/10/09 

20003300 20 Safflower, oil 0.000387 1.000 1.000 Last e 

 Full comment: Last edited 6/10/09 

20003301 20 Safflower, oil-babyfood 0.000387 1.000 1.000 Last e 

 Full comment: Last edited 6/10/09 

95003330 O Sapote, Mamey 0.190000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

03003380 3 Shallot 0.000506 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

26003390 M Sheep, meat 

26003391 M Sheep, meat-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

26003400 M Sheep, meat byproducts 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

26003410 M Sheep, fat 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

26003411 M Sheep, fat-babyfood 0.000270 1.000 1.000 Last e 
Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

PC Code: 600016 

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 Full comment: Last edited 5/1/09 

26003420 M Sheep, kidney 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

26003430 M Sheep, liver 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

15003440 15 Sorghum, grain 0.024000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

15003450 15 Sorghum, syrup 0.016000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

95003460 O Soursop 0.019600 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

09023560 9B Squash, summer 

09023561 9B Squash, summer-babyfood 0.003740 1.000 1.000 Last e 

 Full comment: Last edited 10/18/10 

09023570 9B Squash, winter 0.005620 1.000 1.000 Last e 

 Full comment: Last edited 10/18/10 

09023571 9B Squash, winter-babyfood 0.005620 1.000 1.000 Last e 

 Full comment: Last edited 10/18/10 

95003580 O Starfruit 0.190000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

95003610 O Sugar apple 0.020000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

08003750 8 Tomato 

08003751 8 Tomato-babyfood 0.002300 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

08003760 8 Tomato, paste 

08003761 8 Tomato, paste-babyfood 0.002000 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

08003770 8 Tomato, puree 

08003771 8 Tomato, puree-babyfood 0.001170 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

08003780 8 Tomato, dried 

08003781 8 Tomato, dried-babyfood 0.001450 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

08003790 8 Tomato, juice 

50003820 P Turkey, meat 

50003821 P Turkey, meat-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

50003830 P Turkey, liver 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

50003831 P Turkey, liver-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

50003840 P Turkey, meat byproducts 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

50003841 P Turkey, meat byproducts-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

50003850 P Turkey, fat 

50003851 P Turkey, fat-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

50003860 P Turkey, skin 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

50003861 P Turkey, skin-babyfood 0.000270 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

05023890 5B Turnip, greens 0.202000 1.000 1.000 Last e 

 Full comment: Last edited 7/30/10 

14003910 14 Walnut 

86010000 O Water, direct, all sources 0.000210 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

86020000 O Water, indirect, all sources 0.000210 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

09013990 9A Watermelon 0.003960 1.000 1.000 Last e 

 Full comment: Last edited 5/1/09 

09014000 9A Watermelon, juice 0.003960 1.000 1.000 Last e 
Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

PC Code: 600016 

Page 63 of 71 

 Full comment: Last edited 5/1/09 

15004010 15 Wheat, grain 

15004011 15 Wheat, grain-babyfood 

15004020 15 Wheat, flour 

15004021 15 Wheat, flour-babyfood 

15004030 15 Wheat, germ 0.000624 1.000 1.000 Last e 

 Full comment: Last edited 6/10/09 

15004040 15 Wheat, bran 
Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

PC Code: 600016 

Page 64 of 71 

Attachment 10. Results File – ETU Aggregate Cancer Food Only 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for ETU - AGGREGATE - CHRONIC (1994-98 data) 

Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Dietary2009\ETUAggregate2009\aggregateETUchronicpria2009foodalone_10_18_10_new_leafybra

ssicas_metiram wine grapes onlyceleryincluded.R98 

 Adjustment factor #2 used. 

Analysis Date 10-18-2010/11:21:20 Residue file dated: 10-18-2010/11:19:07/8 

Q* = 0.0601 

COMMENT 1: celery included; Use 9/16/10 pct for leafy brassicas and other new uses; metiram 

wine grapes only 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Lifetime risk 

 Subgroup body wt/day (Q*= .0601) 

-------------------------------------- ------------- ------------- 

U.S. Population (total) 0.000043 2.56E-06 

U.S. Population (spring season) 0.000045 2.69E-06 

U.S. Population (summer season) 0.000044 2.62E-06 

U.S. Population (autumn season) 0.000041 2.44E-06 

U.S. Population (winter season) 0.000041 2.49E-06 

Northeast region 0.000047 2.82E-06 

Midwest region 0.000036 2.13E-06 

Southern region 0.000038 2.27E-06 

Western region 0.000054 3.23E-06 

Hispanics 0.000048 2.86E-06 

Non-hispanic whites 0.000038 2.27E-06 

Non-hispanic blacks 0.000048 2.89E-06 

Non-hisp/non-white/non-black 0.000093 5.56E-06 

All infants (< 1 year) 0.000037 2.22E-06 

Nursing infants 0.000020 1.18E-06 

Non-nursing infants 0.000044 2.62E-06 

Children 1-6 yrs 0.000075 4.48E-06 

Children 7-12 yrs 0.000039 2.36E-06 

Females 13-19 (not preg or nursing) 0.000028 1.67E-06 

Females 20+ (not preg or nursing) 0.000042 2.50E-06 

Females 13-50 yrs 0.000041 2.43E-06 

Females 13+ (preg/not nursing) 0.000104 6.23E-06 

Females 13+ (nursing) 0.000025 1.51E-06 

Males 13-19 yrs 0.000035 2.11E-06 

Males 20+ yrs 0.000038 2.28E-06 

Seniors 55+ 0.000043 2.59E-06 

Children 1-2 yrs 0.000088 5.29E-06 

Children 3-5 yrs 0.000072 4.30E-06 

Children 6-12 yrs 0.000042 2.53E-06 

Youth 13-19 yrs 0.000032 1.90E-06 

Adults 20-49 yrs 0.000039 2.32E-06 

Adults 50+ yrs 0.000043 2.61E-06 

Females 13-49 yrs 0.000039 2.35E-06 

------------------------------------------------------------------------------- 
Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

PC Code: 600016 

Page 65 of 71 
Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

PC Code: 600016 

Page 66 of 71 

Attachment 11. Results File – ETU Aggregate Cancer Food and Water 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for ETU - AGGREGATE - CHRONIC (1994-98 data) 

Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Dietary2009\ETUAggregate2009\aggregateETUchronicpria2009foodandwater_10_18_10_new_leafy

brassicas_metiram wine grapes onlyceleryincluded.R98 

 Adjustment factor #2 used. 

Analysis Date 10-18-2010/09:46:10 Residue file dated: 10-18-2010/09:45:13/8 

Q* = 0.0601 

COMMENT 1: celery included; Use 9/16/10 pct for leafy brassicas and other new uses; metiram 

wine grapes only 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Lifetime risk 

 Subgroup body wt/day (Q*= .0601) 

-------------------------------------- ------------- ------------- 

U.S. Population (total) 0.000047 2.82E-06 

U.S. Population (spring season) 0.000049 2.95E-06 

U.S. Population (summer season) 0.000048 2.90E-06 

U.S. Population (autumn season) 0.000045 2.70E-06 

U.S. Population (winter season) 0.000046 2.75E-06 

Northeast region 0.000051 3.06E-06 

Midwest region 0.000040 2.40E-06 

Southern region 0.000042 2.53E-06 

Western region 0.000059 3.53E-06 

Hispanics 0.000053 3.16E-06 

Non-hispanic whites 0.000042 2.53E-06 

Non-hispanic blacks 0.000052 3.14E-06 

Non-hisp/non-white/non-black 0.000098 5.89E-06 

All infants (< 1 year) 0.000051 3.10E-06 

Nursing infants 0.000025 1.51E-06 

Non-nursing infants 0.000062 3.70E-06 

Children 1-6 yrs 0.000081 4.86E-06 

Children 7-12 yrs 0.000043 2.60E-06 

Females 13-19 (not preg or nursing) 0.000031 1.86E-06 

Females 20+ (not preg or nursing) 0.000046 2.76E-06 

Females 13-50 yrs 0.000045 2.69E-06 

Females 13+ (preg/not nursing) 0.000108 6.49E-06 

Females 13+ (nursing) 0.000031 1.88E-06 

Males 13-19 yrs 0.000038 2.31E-06 

Males 20+ yrs 0.000042 2.52E-06 

Seniors 55+ 0.000048 2.86E-06 

Children 1-2 yrs 0.000095 5.68E-06 

Children 3-5 yrs 0.000078 4.67E-06 

Children 6-12 yrs 0.000046 2.78E-06 

Youth 13-19 yrs 0.000035 2.10E-06 

Adults 20-49 yrs 0.000043 2.57E-06 

Adults 50+ yrs 0.000048 2.87E-06 

Females 13-49 yrs 0.000043 2.59E-06 
Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

PC Code: 600016 

Page 67 of 71 

------------------------------------------------------------------------------- 
Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

PC Code: 600016 

Page 68 of 71 

Attachment 12. Results File – ETU Aggregate Cancer Food and Water – Critical Commodity 

Contribution Analysis 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for ETU - AGGREGATE - CHRONIC (1994-98 data) 

Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Dietary2009\ETUAggregate2009\aggregateETUchronicpria2009foodandwater_10_18_10_new_leafy

brassicas_metiram wine grapes onlyceleryincluded.R98 

 Adjustment factor #2 used. 

Analysis Date 10-18-2010/11:22:35 Residue file dated: 10-18-2010/09:45:13/8 

Q* = 0.0601 

COMMENT 1: celery included; Use 9/16/10 pct for leafy brassicas and other new uses; metiram 

wine grapes only 

=============================================================================== 

 Critical Commodity Contribution Analysis for 

 U.S. Population (total) 

 Total Exposure =.000047 mg/kg bw/day 

 Crop groups with total exposure contribution > 5% 

 Foods/Foodforms with exposure contribution > 1% 

------------------------------------------------------------------------------- 

Crop group -----------Exposure analysis---------- 

 Food mg/kg | % of Total| Lifetime Risk 

 Foodform body wt/day| Exposure |(Q*= .0601) 

-------------------------------------- -----------|-----------|-------------- 

Crop Group = (O) Other 

 Banana (95000230): 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.0000014 3.01% 8.50E-08 

 Cranberry, juice (95001320): 

 240-Cooked; Canned; Cook Meth N/S 0.0000005 1.14% 3.21E-08 

 Grape, wine and sherry (95001790): 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.0000009 1.87% 5.29E-08 

 Mango (95002150): 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.0000020 4.24% 1.20E-07 

 Papaya (95002450): 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.0000005 1.15% 3.24E-08 

 Water, direct, all sources (86010000): 

 FoodForm N/S 0.0000025 5.42% 1.53E-07 

 Water, indirect, all sources (86020000): 

 FoodForm N/S 0.0000019 4.00% 1.13E-07 

-------------------------------------- -----------|-----------|-------------- 

 Total for crop group 0.0000120 25.55% 7.21E-07 

Crop Group = (D) Dairy Products 

 Milk, water (27022240): 

 FoodForm N/S 0.0000014 3.05% 8.60E-08 

-------------------------------------- -----------|-----------|-------------- 

 Total for crop group 0.0000018 3.73% 1.05E-07 

Crop group -----------Exposure analysis---------- 

 Food mg/kg | % of Total| Lifetime Risk 
Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

PC Code: 600016 

Page 69 of 71 

 Foodform body wt/day| Exposure |(Q*= .0601) 

-------------------------------------- -----------|-----------|-------------- 

Crop Group = (1) Root and Tuber Vegetables 

 Potato, tuber, w/o peel (01033000): 

 212-Cooked; Fresh or N/S; Boiled 0.0000006 1.17% 3.31E-08 

-------------------------------------- -----------|-----------|-------------- 

 Total for crop group 0.0000018 3.85% 1.09E-07 

Crop Group = (1C) Tuberous and Corm Vegetables 

 Potato, tuber, w/o peel (01033000): 

 212-Cooked; Fresh or N/S; Boiled 0.0000006 1.17% 3.31E-08 

-------------------------------------- -----------|-----------|-------------- 

 Total for crop group 0.0000017 3.55% 1.00E-07 

Crop Group = (4) Leafy Vegetables (except Brassica) 

 Endive (04011500): 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.0000012 2.58% 7.29E-08 

 Lettuce, head (04012040): 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.0000014 3.02% 8.54E-08 

 Lettuce, leaf (04012050): 

 FoodForm N/S 0.0000062 13.11% 3.70E-07 

-------------------------------------- -----------|-----------|-------------- 

 Total for crop group 0.0000093 19.77% 5.58E-07 

Crop Group = (4A) Leafy Greens 

 Endive (04011500): 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.0000012 2.58% 7.29E-08 

 Lettuce, head (04012040): 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.0000014 3.02% 8.54E-08 

 Lettuce, leaf (04012050): 

 FoodForm N/S 0.0000062 13.11% 3.70E-07 

-------------------------------------- -----------|-----------|-------------- 

 Total for crop group 0.0000089 19.01% 5.37E-07 

Crop group -----------Exposure analysis---------- 

 Food mg/kg | % of Total| Lifetime Risk 

 Foodform body wt/day| Exposure |(Q*= .0601) 

-------------------------------------- -----------|-----------|-------------- 

Crop Group = (5) Brassica (Cole) Leafy Vegetables 

 Cabbage (05010690): 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.0000008 1.81% 5.10E-08 

 212-Cooked; Fresh or N/S; Boiled 0.0000014 2.99% 8.44E-08 

 Collards (05021170): 

 FoodForm N/S 0.0000011 2.39% 6.74E-08 

 Kale (05021940): 

 FoodForm N/S 0.0000009 2.01% 5.68E-08 

 Turnip, greens (05023890): 

 FoodForm N/S 0.0000015 3.14% 8.87E-08 

-------------------------------------- -----------|-----------|-------------- 

 Total for crop group 0.0000089 18.94% 5.35E-07 

Crop Group = (5A) Brassica: Head and Stem 

 Cabbage (05010690): 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 
Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

PC Code: 600016 

Page 70 of 71 

 0.0000008 1.81% 5.10E-08 

 212-Cooked; Fresh or N/S; Boiled 0.0000014 2.99% 8.44E-08 

-------------------------------------- -----------|-----------|-------------- 

 Total for crop group 0.0000043 9.06% 2.56E-07 

Crop Group = (5B) Brassica: Leafy Greens 

 Collards (05021170): 

 FoodForm N/S 0.0000011 2.39% 6.74E-08 

 Kale (05021940): 

 FoodForm N/S 0.0000009 2.01% 5.68E-08 

 Turnip, greens (05023890): 

 FoodForm N/S 0.0000015 3.14% 8.87E-08 

-------------------------------------- -----------|-----------|-------------- 

 Total for crop group 0.0000046 9.88% 2.79E-07 

Crop group -----------Exposure analysis---------- 

 Food mg/kg | % of Total| Lifetime Risk 

 Foodform body wt/day| Exposure |(Q*= .0601) 

-------------------------------------- -----------|-----------|-------------- 

Crop Group = (8) Fruiting Vegetables 

 Pepper, bell (08002700): 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.0000011 2.27% 6.41E-08 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.0000010 2.15% 6.08E-08 

-------------------------------------- -----------|-----------|-------------- 

 Total for crop group 0.0000054 11.59% 3.27E-07 

Crop Group = (9) Curcurbit Vegetables 

 Watermelon (09013990): 

 FoodForm N/S 0.0000006 1.19% 3.37E-08 

-------------------------------------- -----------|-----------|-------------- 

 Total for crop group 0.0000016 3.38% 9.53E-08 

Crop Group = (9A) Melons 

 Watermelon (09013990): 

 FoodForm N/S 0.0000006 1.19% 3.37E-08 

-------------------------------------- -----------|-----------|-------------- 

 Total for crop group 0.0000011 2.43% 6.87E-08 

Crop Group = (11) Pome Fruits 

 Apple, fruit with peel (11000070): 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.0000012 2.64% 7.46E-08 

 Apple, juice (11000100): 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.0000013 2.78% 7.84E-08 

-------------------------------------- -----------|-----------|-------------- 

 Total for crop group 0.0000035 7.44% 2.10E-07 

Crop group -----------Exposure analysis---------- 

 Food mg/kg | % of Total| Lifetime Risk 

 Foodform body wt/day| Exposure |(Q*= .0601) 

-------------------------------------- -----------|-----------|-------------- 

Crop Group = (15) Cereal Grains 

 Wheat, flour (15004020): 

 211-Cooked; Fresh or N/S; Baked 0.0000006 1.19% 3.35E-08 

-------------------------------------- -----------|-----------|-------------- 
Ethylene Thiourea Dietary Exposure Assessment DP Barcode: D366141 

PC Code: 600016 

Page 71 of 71 

 Total for crop group 0.0000016 3.43% 9.69E-08 

Total for crop groups listed above: 0.0000459 97.68% 2.76E-06 

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