exv10w191



 






Exhibit 10.191



THIS NOTE AND THE SECURITIES ISSUABLE UPON CONVERSION HEREOF (THE “CONVERSION SHARES”) HAVE NOT
BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”). THESE
SECURITIES MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO (I) AN EFFECTIVE REGISTRATION STATEMENT
UNDER THE SECURITIES ACT COVERING THIS NOTE OR CONVERSION SHARES OR (II) AN EXEMPTION FROM
REGISTRATION UNDER THE SECURITIES ACT WHERE THE HOLDER HAS FURNISHED TO THE COMPANY AN OPINION OF
ITS COUNSEL THAT AN EXEMPTION FROM REGISTRATION UNDER SUCH ACT IS AVAILABLE.




THE IMMUNE RESPONSE CORPORATION




8% SENIOR SECURED CONVERTIBLE PROMISSORY NOTE




			
	$ 250,000
	 	February 9, 2006
	(Principal Amount)	 	 






          THE IMMUNE RESPONSE CORPORATION, a Delaware corporation (the “Company”), for value
received, hereby promises to pay to the order of Qubit Holdings, LLC (the “Holder”), on
January 1, 2008 (the “Maturity Date”), the principal sum of Two Hundred Fifty Thousand
Dollars (US $250,000), together with interest at the rate of Eight Percent (8%) per annum
(calculated daily on the basis of a 360-day year and actual calendar days elapsed) from the date
hereof until the entire principal and accrued interest thereon shall become paid or otherwise
satisfied, subject to earlier conversion as set forth below.




          The obligations of the Company under this Note are secured by the grant of a security interest
in all of the assets of the Company pursuant to the terms of a certain Security Agreement dated as
of February 9, 2006 (the “Security Agreement”), by the Company in favor of Hudson Asset
Partners, LLC, a Delaware limited liability company (the “Agent”), as agent of the initial
Holder of this Note and the holders of Bridge Notes (as defined below). Such security interest
shall rank pari passu with the security interests in the Company’s assets granted by the Company in
favor of Cheshire Associates LLC (“Cheshire”), in connection with its certain mortgage note
issued by the Company in April 2005 in the original principal amount of $5,740,928 (the
“Cheshire Note”), Cornell Capital Partners, L.P. (“Cornell” and, collectively with
Cheshire, the “Existing Secured Parties”), in connection with its certain debenture issued
by the Company in August 2005 in the original principal amount of $1,000,000 (the “Cornell
Debenture”) and certain senior secured promissory notes up to an aggregate principal amount of
$5,000,000 to be offered by the Company (the “Offering”), after the date hereof, in a
private placement of such notes (the “Bridge Notes”) pursuant to the terms of an
Intercreditor Agreement dated as of February 9, 2006 (the “Intercreditor Agreement”) by and
among the Company and the Existing Secured Parties in favor of the Agent, as agent of the initial
Holder of this Note and the holders of Bridge Notes, who shall become a party to the Intercreditor
Agreement upon the first closing of the Offering.




          All payments shall be made in lawful money of the United States of America at such place as
the Holder hereof may from time to time designate in writing to the Company, and, in absence of any
designation, shall be paid to the Holder at its address set forth in the Holder’s

 









 








Subscription Agreement and shall be credited first to the accrued interest then due and
payable and the remainder applied to principal. If any payment hereunder falls due on a Saturday,
Sunday or legal holiday, it shall be payable on the next succeeding business day and such
additional time shall be included in the computation of interest.




     1. Interest. Interest shall accrue on the principal amount from the date of issuance
and be paid on the Maturity Date, subject to earlier conversion as set forth herein.



     2. Conversion.



          2.1 Optional Conversion. The Holder may convert the entire unpaid principal amount of
this Note and any accrued interest thereon into Common Stock at any time in whole or from time to
time in part commencing on the date on which the Company files with the Secretary of State of the
State of Delaware an amendment to its certificate of incorporation increasing its authorized shares
of Common Stock to an amount sufficient to allow for conversion of this Note and terminating at
5:00 PM, New York Time, on the Maturity Date (the “Conversion Period”).




          2.2 Mandatory Conversion. The entire unpaid principal amount of this Note and any
accrued interest thereon shall be convertible, at the option of the Company (“Company Mandated
Conversion”), into Common Stock at any time on or after (i) the later of (x) the date that is
six months after the date hereof or (y) the date on which a registration statement filed with the
Securities and Exchange Commission (the “SEC”) registering (either for initial issuance or
for resale) the shares of Common Stock underlying this Note shall have been declared effective by
the SEC and (ii) a Certificate of Amendment to the Company’s Certificate of Incorporation has been
filed with the Delaware Secretary of State, increasing the authorized number of shares of Common
Stock to a number sufficient to permit the reservation of all shares of Common Stock into which all
the Notes are convertible; provided, however, that such conversion shall only be
permitted if (A) the closing price of the Common Stock on the principal exchange or market on which
it is then traded has equaled or exceeded $0.10 per share for the 10 of 15 consecutive trading days
immediately preceding the date of the proposed Company Mandatory Conversion and (ii) the trading
volume of the Common Stock during such period has equaled or exceeded two (2%) percent of the
public float for 10 of the same 15 consecutive trading days in which such closing price of the
Common Stock equaled or exceeded $0.10 per share. If such election is made, the Company shall
provide written notice of the Company Mandated Conversion to the Holder within five (5) business
days of such determination (“Company Mandated Conversion Notice”) by mailing, by first
class mail, postage prepaid, a copy of such notice to the Holder.




          2.3 Conversion Price. The conversion price (the “Conversion Price”) shall
initially be Two Cents ($.02) per share of Common Stock.




          2.4 Method of Conversion. The Holder, at its option, may exercise its conversion
right in whole or in part at any time during the Conversion Period by completing and executing the
Notice of Conversion attached to this Note as Attachment I. The Notice of Conversion,
together with this Note, must be received by the Company on or prior to the termination of the
Conversion Period. To the extent that this Note is converted in part, the Company shall execute
and deliver to the Holder a new note identical to this Note except that the principal amount of the
new note shall be equal to the portion of the unpaid principal amount of this Note not converted.
In lieu of issuing a fractional share upon conversion, the Holder will receive the next highest
whole number of shares. The Company shall, or instruct its transfer agent to, issue and deliver
certificates for the shares of

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Common Stock issuable upon conversion within three (3) business days after receipt of the
Notice of Conversion. Delivery by the Company of a Company Mandated Conversion Notice in the case
of a Company Mandated Conversion, when all conditions have been satisfied, shall have the same
effect as cancellation of the original Note.




          2.5 Anti-dilution.




          (a) Change in Capitalization. In case of any stock split (forward or reverse), stock
dividend or similar transaction prior to the date of a conversion (the “Conversion Date”)
which increases or decreases the number of outstanding shares of Common Stock, appropriate
adjustment shall be made by the Board of Directors of the Company to the applicable Conversion
Price.




          (b) Reclassification. In case of any reclassification, capital reorganization or
change of the outstanding Common Stock of the Company (other than as a result of a subdivision,
combination or stock dividend covered by Section 2.5(a)), at any time prior to the Conversion Date,
then, as a condition of such reclassification, reorganization or change, a lawful provision shall
be made, and duly executed documents evidencing the same from the Company or its successor shall be
delivered to the Holder, so that the Holder shall have the right to receive upon conversion
(instead of the original number and type of conversion securities, into which, in fact, this Note
would then no longer be convertible) the kind and amount of shares of Common Stock and other
securities (the “Conversion Shares”) and property receivable upon such reclassification,
reorganization or change, and a change in the Conversion Price, if necessary, that a holder of
Common Stock owning the number of shares of Common Stock which might have been purchased by the
Holder immediately prior to such reclassification, reorganization or change would be entitled to.
In any such case appropriate provisions shall be made in order to respect the rights and interests
of the Holder under this Note.




          (c) Consolidation, Merger and Sale of Assets. In the event of any consolidation of
the Company with or a merger of the Company into another corporation or in case of any sale or
conveyance to another corporation of the property of the Company as an entirety or substantially as
an entirety, whereby (i) the surviving entity is a publicly traded company, and (ii) the
consideration to be received by the holders of the Common Stock includes publicly traded equity
securities in the surviving entity or parent corporation, the Company agrees that a condition of
such transaction will be that the successor or purchasing corporation, as the case may be, shall
assume the obligations of the Company hereunder in writing. In the case of any such consolidation,
merger or sale or conveyance, the Holder shall have the right, until the payment of the entire
principal amount of the Notes and any accrued interest thereon (subject to the right of the Holder
to convert), upon conversion at the applicable Conversion Price in effect immediately prior to such
action, to receive (instead of the original number and type of conversion securities, into which,
in fact, this Note would no longer be convertible) the kind and amount of shares and other
securities and/or property which he would have owned or have been entitled to receive after the
happening of such consolidation, merger, sale or conveyance had this Note been converted
immediately prior to such action, subject to adjustments which shall be as nearly equivalent as may
be practicable to the adjustments provided for in this Section 2. The provisions of this Section
2.5(c) shall similarly apply to successive consolidations, mergers, sales or conveyances.




          (d) Non-Public Successor. In the event of any consolidation of the Company with or a
merger of the Company into another corporation or in case of any sale or conveyance to another
corporation of the property of the Company as an entirety or substantially as an entirety, whereby




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(i) the surviving entity is a non-publicly traded company, or (ii) the consideration to be
received by the Common Stock holders does not include any publicly traded equity securities in the
surviving entity or its parent corporation, the Company agrees that a condition of such transaction
will be that the Company shall mail to the Holder at the earliest applicable time (and, in any
event not less than ten (10) days before any record date for determining the persons entitled to
receive the consideration payable in such transaction) written notice of such record date. Such
notice shall also set forth facts as shall indicate the effect of such action (to the extent such
effect may be known at the date of such notice) on the applicable Conversion Price of and the kind
and amount of Conversion Shares and other securities and property deliverable upon conversion of
this Note. Upon the closing of the transaction referenced in the foregoing notice, the right of
conversion of this Note, shall terminate.




          (e) Exchanges and Distributions With Respect to Common Stock. If the Company shall
exchange for its Common Stock or distribute with respect to its Common Stock other securities
issued by it, the Company shall give notice thereof to the Holder, and the Holder shall have the
right thereafter to convert the Note for (instead of the original number and type of conversion
securities, into which, in fact, this Note would no longer be convertible) the kind and amount of
shares of stock and other securities retained or received by a holder of the number of shares of
Common Stock into which the Note might have been converted immediately prior to such exchange or
distribution, subject to adjustment as provided hereinabove.




          (f) Officer’s Certificate. Whenever the applicable Conversion Price or the number or
type of Conversion Shares is adjusted, the Company shall promptly mail to the Holder a notice of
adjustment. The notice of adjustment shall include a brief statement of the facts requiring the
adjustment and the manner of computing it, and shall be certified by the chief financial officer of
the Company. The determination of the adjustment shall be made by the Company in its sole
discretion and shall be final and binding upon the Holder.




          2.6 Taxes on Conversion. If the Holder converts the Note as described hereunder, the
Company shall pay any documentary, stamp or similar issue or transfer tax due on the issue of
shares of Common Stock upon the conversion. However, the Holder shall pay any such tax which is
due because the shares are issued in a name other than the Holder’s name.




     3. Seniority.



          3.1 Ranking. The Holder’s security interest in the collateral securing the indebtedness
evidenced by this Note and the payment of the principal thereof shall be Senior (as hereinafter
defined) to, and have priority in right of payment over, all other security interests in such
collateral securing other indebtedness of the Company, now outstanding or hereinafter incurred,
except the Bridge Notes, the Cheshire Note and the Cornell Debenture. Pursuant to the
Intercreditor Agreement, the right to receive payment on this Note shall rank equally with the
Bridge Notes, the Cheshire Note and the Cornell Debenture. “Senior,” as used herein, shall be
deemed to mean that, in the event of any default in the payment of the obligations represented by
this Note (after giving effect to “cure” provisions, if any) or of any liquidation, insolvency,
bankruptcy, reorganization, or similar proceedings relating to the Company, all sums payable on
this Note, the Bridge Notes, the Cheshire Note and the Cornell Debenture from such collateral will
first be paid, with interest, if any, before any payment from such collateral is made upon any
other indebtedness, now outstanding or hereinafter incurred, and, in any such event, any payment or
distribution of any character from such collateral which shall be made in respect of any other
indebtedness of the Company, shall be paid

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over to the
Holder, the holders of the Bridge Notes, the holder of the Cheshire Note and the holder of the
Cornell Debenture for application to the payment thereof on a pari passu basis based on all amounts
outstanding under this Note, the Bridge Notes, the Cheshire Note and the Cornell Debenture, unless
and until the obligations under this Notes, the Bridge Notes, the Cheshire Note and the Cornell
Debenture (which shall mean the principal and other obligations arising out of, premium, if any,
interest on, and any costs and expenses payable under such notes and debenture) shall have been
paid and satisfied in full.




          3.2 Restriction of Indebtedness. The Company shall not incur or guaranty any
indebtedness that would be senior, or grant any security interest that would be senior, to this
Note, other than the Bridge Notes, the Cheshire Note and the Cornell Debenture.




          3.3 Payment of Junior Indebtedness. Until an Event of Default, nothing contained in
this Note shall be deemed to preclude or prohibit the Company from making any required payment of
principal or interest on any debt.




     4. Covenants of the Company. The Company agrees and covenants that, until such time
as this Note has been paid in full, the Company will comply with the following covenants:



          4.1 Payment of Principal and Interest. The Company shall duly and punctually pay the
principal of and interest on this Note in accordance with the terms of this Note.




          4.2 Maintenance of Office or Agency. The Company shall maintain an office in the
State of California and/or New York where this Note may be presented or surrendered for payment,
where this Note may be surrendered for transfer or exchange and where notices and demands to or
upon the Company in respect of this Note may be served. The Company will give prompt written
notice to the Holder of the location, and of any change in the location, of such office.




          4.3 Maintenance of Books and Records. The Company shall, and shall cause any
subsidiary to, keep true books and records in which full and correct entries will be made of all
its business transactions, in accordance with sound business practices, and reflect in its
financial statements adequate accruals and appropriations to reserves, all in accordance with
generally accepted accounting principals.




          4.4 Corporate Existence. The Company will do or cause to be done all things necessary
to preserve and keep in full force and effect its corporate existence, rights (charter and
statutory) and franchise; provided, however, that the Company shall not be required
to preserve any right or franchise if the Board of Directors shall determine that the preservation
thereof is no longer desirable in the conduct of the business of the Company and that the loss
thereof is not disadvantageous in any material respect to the Holder.




          4.5 Compliance. The Company shall timely comply with the filing requirements of the
U.S. Securities and Exchange Commission (“Commission”) and the Over the Counter Bulletin
Board or other market on which the Common Stock is then traded, if applicable, with respect to its
obligations to file periodic reports under the Securities Exchange Act of 1934, as amended (the
“Exchange Act”).




          4.6 Financial Statements and Information. The Company will mail or deliver to the
Holder:




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          (a) Quarterly Statements. Within sixty (60) days after the close of each of the three
interim quarterly accounting periods of the Company, an unaudited balance sheet of the Company as
of the end of such period and the related statements of operations, stockholders’ equity and
changes in the financial position for such period.




          (b) Annual Statements. Within one hundred and twenty (120) days after the close of
the fiscal year of the Company, an audited balance sheet of the Company as of the end of the year
and the related statements of operations, stockholders’ equity and changes in financial position
for the periods then ended.




          (c) Other Statements, Etc. Copies of all such financial statements, reports and proxy
statements as the Company shall send to or make available to its stockholders or which it shall
file with the Commission.




          (d) Compliance. So long as the Company is registered under the Exchange Act, the
obligations under Sections 4.6(a) and (b) shall be satisfied by the filing on the Commission’s
EDGAR system of the Company’s Quarterly Report on Form 10-Q for the quarter then ended and the
Annual Report on Form 10-K for the fiscal year then ended.




          4.7 Common Stock Issuable upon Conversion.




          (a) The Company covenants that all Conversion Shares which may be issued upon conversion of
this Note shall, upon issuance, be fully paid and non-assessable, free from all taxes, liens and
charges with respect to the issue thereof, except restrictions on resale or other transfer imposed
under the Securities Act of 1933, as amended, and the Company’s by-laws and certificate of
incorporation, and as may be hereafter amended or restated.




          (b) The Company covenants that as soon as practicable after the final closing of the Offering
pursuant to which this Note is being issued, the Company shall cause a special meeting of its
stockholders to be held for the purpose of amending the Company’s certificate of incorporation to
increase the Company’s authorized Common Stock, and upon obtaining such approval it will at all
times reserve and keep available out of its authorized but unissued and otherwise unreserved Common
Stock, solely for the purpose of enabling it to issue the shares of Common Stock or other
Conversion Shares upon conversion of the Notes as required hereunder, the number of shares of
Common Stock or other Conversion Shares which are then issuable and deliverable upon the conversion
of (and otherwise in respect of) this entire Note (taking into account the adjustments set forth in
Section 2.5 hereof, free from preemptive rights or any other contingent purchase rights of persons
other than the Holder.




          4.8 Restriction on Payment of Dividends and Stock Repurchases. The Company may not,
directly or indirectly, (i) declare or pay any dividend on, or make any distribution to its
stockholders of, any shares of its Common Stock, or (ii) purchase, redeem or otherwise acquire or
retire for value any shares of outstanding Common Stock, without the consent of the Requisite
Holders (as hereinafter defined) as of the date of such consent, which shall not be unreasonably
withheld or delayed. As used in this Note, the term “Requisite Holders” means the holders
of a majority of the aggregate outstanding principal amount of this Note and the Bridge Notes.




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          4.9 Taxes. The Company shall, and cause any subsidiary to, pay prior to delinquency
all taxes, assessments and governmental levies, federal, state and provincial or local, except as
contested in good faith and by appropriate proceedings.




          4.10 Incurring Certain Additional Indebtedness. Unless otherwise agreed to in writing
by the Requisite Holders, the Company shall not issue any debt securities which provide that such
securities shall rank senior to this Note and the other Bridge Notes, except to the extent
permitted in Section 3.2 hereof.




          4.11 Insurance. The Company shall (i) keep all of its properties adequately insured
at all times with responsible insurance carriers against loss or damage by fire and other hazards,
and (ii) maintain adequate insurance at all times with responsible insurance carriers against
liability on account of damage or injury to persons and property including from product liability
and under all applicable workmen’s compensation laws.




     5. Events of Default; Remedies.



          5.1 Events of Default. “Event of Default,” wherever used herein means any one of the
following events (whatever the reason for such Event of Default and whether it shall be effected by
operation of law pursuant to any judgment, decree or order of any court or any order, rule or
regulation of any administrative or governmental body):




          (a) the Company shall fail to pay any amounts owed hereunder as required by the terms of this
Note within five (5) business days after such payment becomes due and payable whether at its
maturity or otherwise; or




          (b) the Company shall fail to perform or observe or otherwise breach any covenant, agreement
or provision to be performed or observed by the Company under this Note (other than a covenant or
warranty a default in whose performance or whose breach is elsewhere in this Section specifically
dealt with), and continuance of such default or breach for a period of ten (10) days after notice
of such failure or breach had been received by the Company; or




          (c) an event of default shall have occurred and be continuing in any of the Bridge Notes, the
Cheshire Note or the Cornell Debenture; or




          (d) the entry of a decree or order by a court of competent jurisdiction adjudging the Company
bankrupt or insolvent, or approving as properly filed a petition seeking reorganization,
arrangement, adjustment or composition of or in respect of the Company under the federal bankruptcy
laws or any other applicable act, law or statute of the United States or any state, district or
territory thereof, or appointing a receiver, liquidator, assignee, trustee, sequestrator (or other
similar official) of the Company or of any substantial part of its property, or ordering the
winding up or liquidation of its affairs, and the continuance of any such decree or order unstayed
and in effect for a period of sixty (60) consecutive days; or




          (e) the institution by the Company of proceedings to be adjudicated bankrupt or insolvent, or
the consent by it to the institution of bankruptcy or insolvency proceedings against it, or the
filing by it of a petition or answer or consent seeking reorganization or relief under the federal
bankruptcy laws or any other applicable act, law or statute of the United States or any state,
district or territory thereof, or the consent by it to the filing of any such petition or to the
appointment of a

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receiver, liquidator, assignee, trustee, sequestrator (or other similar official) of the
Company or of any substantial part of its property, or the making by it of an assignment for the
benefit of creditors, or the taking of corporate action by the Company in furtherance of any such
action; or




          (f) the Company shall have entered against it a final judgment by a court of competent
jurisdiction which, if satisfied, would have a material adverse effect on the financial condition
of the Company, and the same shall remain undischarged for a period of twenty (20) days during
which execution shall not be effectively stayed or bonded; or




          (g) the Company shall be in default in the payment in excess of Fifty Thousand Dollars
($50,000) of money borrowed in one or more transactions (excluding money borrowed under the Bridge
Notes, the Cheshire Note or the Cornell Debenture which is covered by Section 5.1(c) hereof), the
lender(s) thereof shall have declared the amount in default and such default shall not have been
cured or contested in good faith for a period of twenty (20) days after such declaration; or




          (h) the Company shall fail to perform or observe or otherwise breach, in any material respect,
any covenant, agreement or provision to be performed or observed by it under the Security Agreement
or the Intercreditor Agreement, and such failure shall not be rectified or cured within ten (10)
days after written notice of such failure or breach has been received by the Company; or




          (i) if the Company shall suspend its operations and such suspension shall remain in effect for
a continuous period exceeding thirty (30) days; or




          (j) any representation or warranty of the Company made to the Holder in, pursuant to or in
connection with this Note, the Security Agreement or the Intercreditor Agreement, shall be false in
any material respect on the date as of which it was made and such breach shall not be rectified or
cured within ten (10) days after written notice thereof by any Holder to the Company; or




          (k) if, after 75 days from the final closing of the Offering of the Bridge Notes, the Company
fails to have available a sufficient number of authorized but unissued and otherwise unreserved
shares of Common Stock available for issuance upon any conversion of the Note.




          5.2 Enforcement of Remedies. In case an Event of Default (other than an Event of
Default described in Section 5.1(d) and 5.1(e) hereof) has occurred and is continuing, the Agent,
or its successor, as agent on behalf of the Holder and the holders of the Bridge Notes, acting upon
the direction of the Requisite Holders by written notice to the Company, may declare the principal
amount of this Note, plus accrued interest, to be immediately due and payable, and upon any such
declaration such principal and accrued interest shall become due and payable immediately without
presentation, protest, further demand or notice of any kind, all of which are hereby expressly
waived by the Company and all endorsers of this Note. In case an Event of Default described in
Sections 5.1(d) or 5.1(e) above occurs, such amounts will become due and payable without any
declaration or any act on the part of the Agent or the Holder and the Company and all endorsers of
this Note hereby expressly waive presentment for payment, protest, further demand or notice of any
kind.




          5.3 Notice to Holders of Record. If a Holder of any of the Bridge Notes shall demand
payment thereof or take any other action of which the Company shall have actual knowledge in
respect of an alleged default under the Bridge Notes, the Company will promptly give written
notice, specifying such action and nature of the alleged default, to the Holder.




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          5.4 Waiver by Company. To the extent permitted by applicable law, the Company hereby
agrees to waive, and does hereby absolutely and irrevocably waive and relinquish the benefit and
advantage of any valuation, stay, appraisement, extension or redemption laws now existing or which
may hereafter exist, which, but for this provision might be applicable to any sale made under the
judgment, order or decree of any court or otherwise, based on this Note or any claim for interest
on this Note or under the Security Agreement or any foreclosure thereunder.




          5.5 Modifications and Waivers. No course of dealing between the Company and the
Holder and no delay on the part of the Holder or the Agent in exercising any of the Holder’s rights
under this Note shall operate as a waiver of the rights of the Holder under this Note. Any
provision of this Note and the Bridge Notes to the contrary notwithstanding, changes in or
additions to this Note and the Bridge Notes may be made, and compliance with any term, covenant,
condition or provision set forth in this Note or the Bridge Notes may be omitted or waived (either
generally or in a particular instance and either retroactively or prospectively), and any default
or Event of Default and the consequences thereof may be waived, by a consent or consents in writing
signed by the Company and the Requisite Holders; provided, however, that (i) the
Company shall deliver copies of the form of such consent or consents to the Holder or any holder of
the Bridge Notes if the Holder or such other holder did not execute the same; (ii) no such consent
shall be effective to reduce the principal of or rate of interest payable on this Note without the
consent of the Holder if this Note is so affected; (iii) no such consent shall be effective to
change the percentage of principal amount of this Note and the Bridge Notes the consent of the
holders of which is required under this Section 5.5; and (iv) no such consent shall extend to or
impair any obligation not expressly waived or impair any right consequent thereon. Any consent may
be given subject to satisfaction of conditions stated therein. A waiver on any occasion shall not
be construed as a bar to or a waiver of any such right or remedy on any future occasion.




          5.6 Cost and Expense of Collection. The Company and all endorsers of this Note will,
to the extent permitted under applicable law, pay to the Holder all reasonable costs and expenses
of collection and enforcement of this Note, including, without limitation, reasonable fees and
expenses of the attorneys of the Holder.




     6. Lost Note. Upon receipt by the Company of evidence satisfactory to it of the loss,
theft, destruction or mutilation of this Note, and (in case of loss, theft or destruction) of
indemnity satisfactory to it, and upon reimbursement to the Company of all reasonable expenses
incidental thereto, and upon surrender and cancellation of this Note, if mutilated, the Company
will make and deliver a new Note of like tenor in lieu of such Note.



     7. Miscellaneous Provisions.



          7.1 Benefits. This Note shall be binding upon the Company and its successors and
assigns and shall inure to the benefit of the Holder and its heirs, administrators and permitted
assigns and transferees.




          7.2 Notices. All communications provided for herein or with reference to this Note
shall be deemed to have been sufficiently given or served for all purposes if delivered in person,
or three (3) business days after being sent by certified or registered mail, postage and charges
prepaid, or one (1) business day after being sent by recognized overnight courier, to the following
addresses: if to the Company, at its office, 5931 Darwin Court, Carlsbad, California, 92008;

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Attention: President,
or to the Holder at its address set forth in the records of the Company, or at any other
address duly designated by the Company or the Holder to the other.




          7.3 Entire Agreement. This Note, together with the Security Agreement and the
Intercreditor Agreement, sets forth the entire agreement between the Company and the Holder with
respect to the subject matter contained herein. If there is a conflict between the provisions in
this Note and the provisions of the Security Agreement or the Intercreditor Agreement, the
provisions of this Note shall govern.




          7.4 Severable. If any term or provision of this Note shall be held invalid, illegal
or unenforceable, the validity, legality and enforceability of all other terms and provisions
hereof shall in no way be affected thereby.




          7.5 Amendment. Subject to Section 5.5, this Note may not be changed, modified or
amended except by an agreement in writing signed by the Company and the Holder.




          7.6 Governing Law. This Note shall be deemed to be a contract made under, and to be
construed in accordance with, the laws of the State of New York, without giving effect to conflicts
of law.




          7.7 Jurisdiction of Disputes; Waiver of Jury Trial. In the event of any claim under
this Note with respect to any matters described or contemplated herein, the Holder and the Company
agree (i) that any legal suit, action or proceeding arising out of or relating to this Note shall
be instituted exclusively in New York State Supreme Court, County of New York, or in the United
States District Court for the Southern District of New York, (ii) waive any objection which a party
may have now or hereafter to the venue of any such suit, action or proceeding, and (iii)
irrevocably consent to the jurisdiction of the New York State Supreme Court, County of New York,
and the United States District Court for the Southern District of New York in any such suit, action
or proceeding. Each of the Holder and the Company further agrees to accept and acknowledge service
of any and all process which may be served in any such suit, action or proceeding in the New York
State Supreme Court, County of New York, or in the United States District Court for the Southern
District of New York and agree that service of process upon it mailed by certified mail to its
address set forth herein shall be deemed in every respect effective service of process upon it, in
any such suit, action or proceeding. THE HOLDER AND THE COMPANY EACH WAIVES THE RIGHT TO A TRIAL
BY JURY IN ANY PROCEEDING IN CONNECTION WITH THIS NOTE, AND AGREES TO TAKE ANY AND ALL ACTION
NECESSARY OR APPROPRIATE TO EFFECT SUCH WAIVER.




          7.8 Section Headings. The descriptive section headings herein have been inserted for
convenience only and shall not be deemed to limit or otherwise affect the construction of any
provisions hereof.




          7.9 Investment Intent. The Holder represents, by acceptance of this Note and the
associated common stock purchase warrant (the “Warrant”) issued to the Holder in connection with
the issuance of this Note, that it is acquiring this Note, and the Warrant and would acquire the
Common Stock underlying this Note and the Warrant, for its own account for investment and not with
a view to distribution.




10









 








          IN WITNESS WHEREOF, the Company has caused this Note to be signed in its corporate name by its
President, attested by its Secretary, and dated the day and year first above written.




	 	 	 	 	 	 	 
	 	 	THE IMMUNE RESPONSE CORPORATION	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 

Joseph F. O’Neill, CEO & President
	 	 






ATTEST:




	 	 	 	 	 	 	 
	By:
	 	 	 	 	 	 
	 

	 	 

Michael K. Green, Secretary
	 	 	 	 






11









 





ATTACHMENT I




NOTICE OF CONVERSION




OF




8% SENIOR SECURED CONVERTIBLE PROMISSORY NOTE




TO: THE IMMUNE RESPONSE CORPORATION




     Pursuant to the 8% Senior Secured Convertible Promissory Note (the “Note”), attached hereto,
dated February 9, 2006, issued by The Immune Response Corporation, a Delaware corporation (the
“Company”), to the undersigned (the “Holder”), the Holder hereby:



     1) Irrevocably elects to convert the principal and accrued interest under the Note into
Conversion Shares, as defined in the Note, in the amount of ___Dollars ($___)(in the event no
amount is specified, the entire principal and accrued interest outstanding under the Note shall be
converted);



     2) Requests that a certificate for the Conversion Shares be issued in the name of undersigned,
or, in the name and address of another person (the “Assignee”) are specified below provided, that,
if the Conversion Shares are not covered by a registration statement effective under the Securities
Act of 1933, the Assignee shall deliver a representation letter in form satisfactory to the
Company:



	 	 	 	 	 
	 

	 	 

	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	 

	 	 	 	 
	 

	 	(Name, address and tax identification number of person	 	 
	 

	 	other than undersigned in whose name Conversion Shares	 	 
	 

	 	are to be registered).	 	 






     3) Requests that, if the entire principal and accrued interest outstanding is not hereby
converted into Conversion Shares, a new Note of like tenor for the remaining outstanding balance be
issued and delivered to the undersigned at the address stated below.



	 	 	 	 	 	 	 
	Dated:
	 	 	 	 	 	 
	 

	 	 

	 	 

Signature
	 	 





(This signature must conform in all respects to the name of the Holder as specified on the face of
the Note.)




	 	 	 	 	 
	 

Tax Identification Number

	 	 

Printed Name
	 	 






Address: