Exhibit 4.16

PROMISSORY NOTE

September 27, 2002
Knoxville, Tennessee

FOR VALUE RECEIVED, the undersigned,Provectus Pharmaceuticals, Inc., a Nevada corporation with its
principal place of business at 7327 Oak Ridge Highway, Suite A, Knoxville, Tennessee 37931 ("Maker") promises to pay to the order of Eric A. Wachter, an
individual with his principal residence at 138 Bay Path Drive, Oak Ridge, Tennessee 37830
("Holder"), the Principal Amount calculated as set forth in Section 1 of this Note (the "Principal
Amount").

TERMS AND CONDITIONS

1. Principal Amount

The Principal Amount shall be equal to the sum of the amounts identified under the column headed "Advanced Amount" onSchedule Ato
this Note (each, an "Advanced Amount"). Holder, in his sole
discretion, may advance to Maker an Advanced Amount from time to time after the date hereof until the Maturity Date. Upon the advancement by Holder of an Advanced Amount, Holder shall record on Schedule Ato this Note the Advanced Amount and the date on which it was advanced to Maker (the "Advance
Date"), and Holder and a duly authorized officer of Maker shall executeSchedule Ato acknowledge the advancement by
Holder and receipt by Maker of the Advanced Amount.

2. Interest

Subject to the limitations hereinafter set forth, each Advanced Amount shall bear interest from the applicable Advance Date to the Maturity Date at a rate equal
to the lesser of (a) five percent (5%) per annum, compounded monthly, or (b) the maximum effective rate of interest which Holder lawfully may charge from time to time. In the event that
the foregoing provisions should be construed by a court of competent jurisdiction not to constitute a valid, enforceable designation of a rate of interest or method of determining same, the Principal
Amount shall bear interest prior to maturity at the maximum effective rate of interest which Holder lawfully may charge under applicable statutes and laws from time to time in effect.

3. Payment

Maker will pay the Principal Amount due under this Note, in full, to the order of Holder, on or before December 31, 2009 (the
"Maturity Date"). Interest upon the unpaid balance of the Principal Amount, calculated as above provided, shall accrue and be payable quarterly in
arrears on each March 31, June 30, September 30 and December 31 hereafter (each, an "Interest Payment Date"), commencing on
June 30, 2003. All installments of both principal and interest on this Note shall be made at the principal place of business of Holder set forth above, or at such other place as Holder of this
Note may designate in writing, in lawful money of the United States of America, which shall be legal tender in payment of all debts and dues, public and private, at the time of payment.

4. Prepayment

This Note may be voluntarily prepaid at any time, or from time to time, by Maker without notice or penalty. All prepayments received on this Note shall be applied
to the reduction of principal.

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5. Events of Default

The occurrence of any one or more of the following events with respect to Maker, which event is not remedied within 14 days after written notice thereof is
given to Maker by Holder, shall constitute an event of default hereunder ("Event of Default"):



6. Remedies

Upon the occurrence of an Event of Default hereunder (unless all Events of Default have been cured or waived by Holder), Holder, at its option, may
(a) declare the entire Principal Amount of this Note immediately due and payable, by written notice to Maker, regardless of any prior forbearance; and (b) exercise any and all rights and
remedies available to it under applicable law, including without limitation the right to collect from Maker all sums due under this Note. Maker shall pay all costs and expenses incurred by or on
behalf of Holder in connection with Holder's exercise of any or all of its rights and remedies under this Note, including without limitation attorneys' fees and expenses.

7. Notice by Maker

Maker shall notify Holder immediately after the occurrence of any Event of Default of which Maker acquires knowledge.

8. Parties in Interest; No Transfer

This Note shall be binding upon and inure to the benefit of Holder and Maker and their legal representatives, successors and permitted assigns. This Note may not
be assigned by Maker without the prior written consent of Holder. This Note may not be assigned by Holder without the prior written consent of Maker.

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9. Amendment

No provision of this Note may be waived, altered or amended, except by written agreement between the Parties.

10. Waiver

Any waiver by Maker or Holder of a breach of any provision of this Note shall not operate or be construed as a waiver of any subsequent breach of the same or any
other provision hereof.

11. Waiver of Presentment

Maker and any endorsers or guarantors hereof waive protest, demand, presentment and notice of dishonor, and agree that this Note may be extended, in whole or in
part, without limit as to the number of such extensions, or the period or periods thereof, and without notice to them and without affecting their liability thereon.

12. Entire Agreement

This Note sets forth the entire agreement between the Parties relating to the subject matter hereof and supersedes any prior oral or written agreement between the
Parties.

13. Severability

If any provision of this Note or the application thereof to any Party or circumstances is held invalid or unenforceable, the remainder of this Note and the
application of such provision to other parties or circumstances will not be affected thereby and the provisions of this Note shall be several in any such instance.

14. Governing Law; Forum



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15. Certain Provisions Relating to Interest

It is the intention of Holder and Maker to comply strictly with all applicable usury laws; and, accordingly, in no event and upon no contingency shall Holder ever
be entitled to receive, collect, or apply as interest any interest, fees, charges, or other payments equivalent to interest, in excess of the maximum rate which Holder may lawfully charge under
applicable statutes and laws from time to time in effect; and, in the event that the holder hereof ever receives, collects, or applies as interest, any such excess, such amount which, but for this
provision, would be excessive interest, shall be applied to the reduction of the principal amount of the indebtedness evidenced hereby; and, if the principal amount of the indebtedness evidenced
hereby, and all lawful interest thereon, is paid in full, any remaining excess shall forthwith be paid to Maker, or other party lawfully entitled thereto. All interest paid or agreed to be paid by
Maker shall, to the maximum extent permitted by applicable law, be amortized, prorated, allocated and spread throughout the full period until payment in full of the principal, so that the interest
hereon for such full period shall not exceed the maximum amount permitted by applicable law. Any provision hereof, or of any other agreement between Holder and Maker, that operates to bind, obligate,
or compel Maker to pay interest in excess of such maximum lawful contract rate shall be construed to require the payment of the maximum rate only. The provisions of this paragraph shall be given
precedence over any other provision contained herein or in any other agreement between Holder and Maker that is in conflict with the provisions of this paragraph.

16. Waiver of Jury Trial

TO THE FULLEST EXTENT PERMITTED BY LAW, THE PARTIES HERETO HEREBY WAIVE THEIR RESPECTIVE RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR
ARISING OUT OF THIS NOTE OR ANY DEALINGS BETWEEN THEM RELATING TO THE SUBJECT MATTER OF THIS TRANSACTION. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL-ENCOMPASSING OF ANY AND ALL
DISPUTES THAT MAY BE FILED IN ANY COURT AND THAT RELATED TO THE SUBJECT MATTER OF THIS NOTE, INCLUDING WITHOUT LIMITATION CONTRACT CLAIMS, TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER
COMMON-LAW AND STATUTORY CLAIMS. THE PARTIES HERETO ACKNOWLEDGE THAT THIS WAIVER IS A MATERIAL INDUCEMENT TO ENTER INTO A BUSINESS RELATIONSHIP AND THAT EACH HAS ALREADY RELIED ON THE
WAIVER IN ENTERING INTO THIS NOTE. THE PARTIES HERETO FURTHER WARRANT AND REPRESENT THAT EACH HAS REVIEWED THIS WAIVER WITH LEGAL COUNSEL, AND THAT EACH KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL
RIGHTS FOLLOWING CONSULTATION WITH LEGAL COUNSEL. THIS WAIVER SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR
MODIFICATIONS TO THIS NOTE OR TO ANY OTHER DOCUMENTS OR AGREEMENTS RELATING THERETO. IN THE EVENT OF LITIGATION, THIS NOTE MAY BE FILED AS A WRITTEN CONSENT TO A TRIAL BY THE COURT.

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SIGNATURE

IN WITNESS WHEREOF, Maker has caused this Note to be executed on the date first set forth above.

| |  | PROVECTUS PHARMACEUTICALS, INC., a Tennessee corporation
| |  | --------------------------------------------------------
| |  | By:                                                     
| |  |                                                         
| |  | Name:                                                   
| |  |                                                         
| |  | Title:                                                  
| |  |                                                         

ACCEPTANCE

Holder accepts and acknowledges receipt of this Note on the date first set forth above.

| |  | ERIC A. WACHTER, an individual resident of the State of Tennessee
| |  | -----------------------------------------------------------------
| |  | Signed:                                                          
| |  |                                                                  

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