2005 STOCK OPTION PLAN



 Exhibit 4.22 
 Confidential 
 GPC Biotech AG 
 Martinsried/Planegg, Germany 
 “2005 Stock Option Plan” 
 (Option Terms) 
 Preamble 
 The Annual Shareholders’ Meeting of GPC Biotech AG (hereinafter the “Company” or “GPC”) adopted a resolution on June 8, 2005, implementing
the 2005 Stock Option Plan for employees of both the Company and affiliated companies at home and abroad (hereinafter the “Optionees”). 
 The
terms of the 2005 Stock Option Plan are as follows: 
 § 1 
 Form and Classification of the Option Right; Option Ledger 
  

	(1)	Optionees receive registered option rights that constitute the right to acquire the number of no-par value shares of the Company specified in the option offer or in the warrant.


  

	(2)	The option rights may be certificated by several registered global warrants. There is no entitlement to (individual) certification. 









	(3)	A stock ledger with an “option rights” column (hereinafter the “Option Ledger”) is kept at the exercise agent (cf. § 17) on behalf of the Company, in which
the option rights are recorded along with the subscription price (cf. § 7 para 1), the series and number, as well as the holder of the option rights identified by name, date of birth and domicile. In particular, the Option Ledger also contains
the information necessary for determining the period pursuant to § 13 para 1 (“Vesting Period”). 

  

	(4)	The only persons deemed Optionees relative to the company are those who are recorded as such in the Option Ledger. 

 § 2 
 Structure of the Option
Right 
  

	(1)	Under the present terms and subject to the adjustments pursuant to § 7 and § 8, the option rights may be exercised at a ratio of 1:1 for no-par value registered shares of
the Company as the options issuer in return for payment of the base price to be established pursuant to § 7 (option right). 

  

	(2)	The Company’s Annual Shareholders’ Meeting created contingent capital as of June 8, 2005, to secure the option rights to be granted to the Optionees. The
Company’s Management Board may decide whether the no-par value shares needed to discharge the exercised option rights shall be provided from the available contingent capital or from a program for the acquisition of treasury stock that has been
adopted or may be adopted by the Annual Shareholders’ Meeting. 

 § 3 
 Acquisition Periods; Term 
  

	(1)	The subscription rights may be offered to the beneficiaries within the last ten weekdays of each calendar month (acquisition period pursuant to Section 193 para 2 no 4 AktG
(Aktiengesetz - German Stock Corporation Act). The effective date of the option issue is the date on which the Management Board — or, insofar as that body itself is a beneficiary, the Supervisory Board — has made an offer to the
Optionee for subscription to the option rights, if said offer was accepted within the subscription period. 

  

	(2)	The term of the subscription rights to be issued is up to ten years from the date the subscription rights were issued. The subscription rights shall expire without compensation at
maturity. 

  

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 § 4 
 Waiting- and Notice Period 
 Pursuant to § 193 para 2 no 4 German Stock Corporation Act, the beneficiaries may
exercise the subscription rights no sooner than two years after the subscription rights were granted. Moreover, the subscription rights may be exercised only if the notice periods established by the Company in the offer letter or in the (global)
warrants pursuant to § 13 para 1 have expired after such two-year waiting period. 
 § 5 
 Exercise Period 
  

	(1)	Subscription rights may not be exercised from the day on which the Company announces an offer to its shareholders to subscribe to new shares or bonds with conversion or option
rights by means of a notice sent to all shareholders or by publishing such offer in the Corporations Gazette [Gesellschaftsblatt] or another gazette for mandatory stock exchange publications [Börsenpflichtblatt] of the
Frankfurt/Main Stock Exchange until the last day of the exercise period. 

  

	(2)	In addition, the subscription rights may be exercised in each instance only during the six-week period beginning with the publication of the quarterly reports or the annual
financial statements (exercise period pursuant to Section 193 para 2 no 4 [German] Stock Corporation Act ). Subscription rights may not be exercised under any circumstances from December 24 through 31 of a calendar year.


  

	(3)	The Management Board is authorized to impose further restrictions on the exercise period. 

 § 6 
 Performance Targets 
  

	(1)	Notwithstanding § 4 and § 5, the subscription rights may be exercised only if the closing price of the stock outperforms a benchmark index (performance target pursuant to
Section 193 para 2 no 4 German Stock Corporation Act ). 

  

	(2)	The benchmark index shall be the Prime IG Biotech Index of the Frankfurt/Main Stock Exchange (the “Price Index”). 

  

	(3)	The Price Index, as well as the stock’s closing price on the day the subscription rights are issued, shall be the starting benchmark for measuring performance. The subscription
rights may be exercised only if the closing price outperforms the Price Index. The date four weeks prior to the exercise of the subscription rights shall be the governing date for purposes of comparison. 

  

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	(4)	The price of the GPCB stock in the XETRA closing auction of the Frankfurt/Main Stock Exchange for one no-par value share of the Company shall be considered the closing price.


 § 7 
 Subscription Price 
  

	(1)	Under the option terms, each subscription right carries the right to subscribe to one no-par value registered share of the Company. The subscription price to be paid upon exercise
of the subscription right for subscription to one no-par value share shall correspond to the average of the closing prices of the Company’s no-par value shares in the XETRA closing auction on the Frankfurt/Main Stock Exchange during the last
five trading days prior to the granting of the subscription rights, but, at a minimum, to the pro rata amount of the capital stock represented by one share of GPC Biotech AG. 

  

	(2)	In the event of a capital increase from Company assets, any existing contingent capital pursuant to Section 218 German Stock Corporation Act shall be increased at the same
ratio as the capital stock. The subscription ratio pursuant to § 2 para 1 shall increase by the same ratio. Fractional shares that arise as a result of such capital increase from Company assets shall not be considered at the time the option
right is exercised. 

 § 8 
 Adjustment of the Option Rights 
  

	(1)	In the event of a merger of the Company into another company, a change in the Company’s corporate form, a change in the nominal value of the shares, or any comparable measures
that impair the Optionees’ rights through a loss of or a change in the shares underlying the option rights in accordance with the present option terms, the option right shall be replaced by the right to acquire, in each case, at the base price,
that number of shares of stock, capital shares, or other ownership interests in the Company or its legal successor (which take the place of the Company’s stock) whose value corresponds to the market value of the Company’s stock at the time
such measure is executed. For the rest, the provisions of the present option terms shall remain applicable without limitations. 

  

	(2)	 In the event of a capital reduction through a reverse split (Section 222 para 4 German Stock Corporation Act) or through the redemption of shares (Section 237
German Stock Corporation Act), the subscription ratio shall be adjusted by multiplying it by the factor obtained by dividing the number of shares subsequent to the capital reduction by the number of shares prior to the capital reduction. Fractional
shares that 



  

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arise as a result of a capital reduction shall not be made available at the time the subscription right is exercised. 


  

	(3)	The Optionees are not entitled to any rights to dividends or other distributions in connection with the shares underlying the option rights until the option right is exercised.


 § 9 
 Exercise Procedure; Issuance of New Shares 
  

	(1)	In order to exercise the option right, the Optionee shall 

  

	 	a)	submit a written notice of exercise, in duplicate, to the exercise agent or to a fiduciary agent engaged for that purpose (cf. § 17) using the form available from such exercise
agent or fiduciary agent; and 

  

	 	b)	pay the full subscription price in euros, free of costs and charges to the Company, to the bank account of the Company as indicated on the exercise notice form.


  

	(2)	Notices received by the exercise agent during the periods indicated in § 4 and § 5 shall be considered to have been submitted and received as of the following banking day
on which exercise of the option right is again permitted. The Optionee may retract his or her exercise notice only as long as such notice is not yet deemed to have been received. 

  

	(3)	New shares shall be printed and delivered in the form provided for by the Company’s applicable Articles of Incorporation, as amended. Delivery shall be authorized — to the
extent possible and subject to full payment of the subscription price — within ten banking days after the exercise notice has taken effect. This requires the authorization of a financial institution by the Company. Should the delivery of the
shares be delayed due to circumstances outside of the control of the Company, the Company shall not be liable for such delay. 

  

	(4)	In the event that the Optionee intends to sell the new shares acquired through exercise of the option immediately after receiving them, the Company, in the interest of placing the
shares in a manner not disruptive to the market, shall be entitled to offer the new shares arising from multiple exercises on behalf of the Optionees and in a manner that safeguards their interests, for example, to institutional investors as blocks
of shares. At the request of the Company, the Optionees shall cooperate in such placement in a suitable and appropriate manner designed not to disrupt the market. 

  

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	(5)	New shares may be issued only in accordance with the provisions of the present option terms and not prior to full payment of the subscription price pursuant to § 7 (cf.
Section 199 para 1 German Stock Corporation Act). 

  

	(6)	The exercise of the Option shall be entered into the electronic stock ledger of the Company and is deemed complete with the delivery of the shares. 

 § 10 
 Participation Rights of
the New Shares 
 The shares resulting from the exercise of the option right participate in profits from the beginning of the previous fiscal year —
if they result from such exercise prior to the onset of the Company’s Annual Shareholders’ Meeting — otherwise, from the beginning of the fiscal year in which they are created through the exercise of the option right. 
 § 11 
 Disposition of Option
Rights 
  

	(1)	The option rights may not be transferred under any circumstances. 

  

	(2)	Other dispositions of the option rights, the granting of subinterests, the establishment of a trust, or entering into short positions by conceding the option rights granted to the
Optionee to third parties, as well as comparable closing transactions which, economically, result in a disposal of the option rights, are equally impermissible. 

  

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	(3)	Breaches of paras 1 and/or 2 shall result in forfeiture of the option rights. The Management Board, subject to agreement with the Supervisory Board, may approve dispositions
pursuant to para 1 or 2, insofar as they are reported to the Management Board in advance, if the Company or the Optionee have a justified interest therein. 

  

	(4)	Notwithstanding paras 1 and 2, Optionees shall be authorized to sell their option rights after the expiration of the two-year waiting period (Section 193 para 2 no 4 German Stock
Corporation Act ) or after the expiration of the vesting period specified in the warrants to a bank to be designated by the Company. 

 § 12 
 Devolution of Inheritance 
  


	(1)	The option rights shall be freely inheritable, insofar as they have not been terminated pursuant to § 13. The heirs shall be subject to the provisions of the present
option terms. 

  

	(2)	The heirs shall be required to report their inheritance status to the Company and to prove their identity in accordance with Section 35 GBO (Grundbuchordnung - German
Land Registry Act). 

 § 13 
 Vesting Period; Termination of the Option Rights 
  

	(1)	As a rule, option rights may be terminated over a period not to exceed four (4) years (“Vesting Period”), where the expiration of the Vesting Period of all option
rights granted to the Optionee need not be uniformly distributed across the Vesting Period but may be staggered instead (e.g. 50% after two years and the remainder after four years, or one quarter annually across four years). The Vesting Period
begins with the issuance of the warrant. In each individual case, the Vesting Period shall be established by the Management Board or the Supervisory Board — depending on which body is responsible therefor — in accordance with internal
guidelines, if any, to be jointly formulated by these bodies and communicated to the Optionee in the option offer. Insofar as warrants certificating the option right are issued, the expiration of the Vesting Period is also set forth in the
respective warrant. 

  

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	(2)	The Company or companies affiliated with it, now or in the future, may terminate an option right that is still subject to a Vesting Period pursuant to para 1 without prior notice
and compensation if the Optionee’s employment is terminated prior to the expiration of the Vesting Period established for the option right. The termination of option rights takes effect upon receipt of a separate written termination notice, but
at the earliest, 

  

	 	a)	in case the Optionee gives notice, upon receipt of such notice; 

  

	 	b)	in case the Optionee is terminated, as of the effective date of such termination (end of the employment contract) or, in case the Optionee is laid off, at the time of such layoff;


  

	 	c)	in case the Optionee gives notice for cause, at the time the Optionee’s termination would have taken effect — assuming that a termination notice from the Company or a
company affiliated with it, now or in the future, exists at the time the Optionee gives notice; or 

  

	 	d)	in all other cases, at the time the employment contract actually ends (e.g. through termination agreement, death, early retirement, family leave, and so forth).


  

	(3)	The Company or the companies affiliated with it, now or in the future, may terminate an option right that is no longer subject to a Vesting Period pursuant to para 1 without prior
notice and compensation, 

  

	 	a)	if the Optionee has not exercised his or her option right within three (3) months [in case of death, within six (6) months] of the effective date of the termination
pursuant to para 2 or 

  

	 	b)	if the Optionee has not exercised his or her option right within three (3) months (in case of death, within six (6) months) of the withdrawal of the affiliate employing
the Optionee from the Group (interest of less than 50% in the capital stock or nominal capital), 

 where the exercise of such
option right would have been possible, taking the waiting period pursuant to § 4 and the exercise periods pursuant to § 5 into account. If an option right cannot be exercised pursuant to the provisions of § 4 and § 5 at the time
the termination takes effect, the period begins when the exercise requirements set forth in § 4 and § 5 are satisfied. 
  

	(4)	 In exceptional cases, the Management Board — or, if that body itself is affected, the Supervisory Board — may forgo termination of some or all of the
option rights if such termination of the option rights would seem inequitable in the specific case 



  

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(suspension of employment owing to family leave, permanent disability, early retirement, and so forth). The same applies if the option rights are intended as
a substitute for a severance payment, if any, owed at the expiration of the employment contract or board appointment. In individual cases, the decision to forgo termination of the option right may be made conditional upon the requirement that the
Vesting Period be extended by a period commensurate with the suspension of the employment relationship (e.g. owing to family leave or unpaid vacation). 


  

	(5)	If the Optionee’s employment contract and/or board appointment with the Company or a company affiliated with it, now or in the future, ends — for whatever reason —
and if it is replaced by a new employment contract or board appointment (e.g. switch from the Management Board to the Supervisory Board) with the Company or a company affiliated with it, now or in the future, the aforementioned termination rights
shall not apply to such expiration but rather only to the expiration of the new employment contract or the new board appointment. 

  

	(6)	The Company is authorized to terminate the option right without prior notice effective immediately if and as soon as bankruptcy proceedings are instituted with regard to the
Optionee’s assets, the institution of bankruptcy proceedings is denied for lack of assets, or execution is levied upon option rights or warrants by a creditor and such execution is not lifted within six (6) months (upon expiration of the
six-month period). 

  

	(7)	The Company may require the Optionee or any other possessor to return any previously issued warrants that have been terminated. 

  

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 § 14 
 Taxes 
 The Optionee shall be liable for paying all taxes due in connection with the granting or exercise of the
option rights, including church taxes and the solidarity surcharge, and the Company shall deduct such taxes and duties, to the extent prescribed by law, from the Optionee’s salary and, if applicable, pay them to the respective corporate revenue
service by way of withholding. Moreover, the Company may require the Optionee to prove that the respective taxes have been paid or provide adequate security before it issues any shares to the Optionee. The Company shall report any failure or
inability on the part of the Optionee to satisfy his or her duties under this provision to the corporate revenue service. 
 § 15

 Insider Trading Rules 
  

	(1)	The Company hereby advises Optionees that they may be subject to insider trading rules and could be held criminally liable if they fail to comply with such rules. Insiders are
prohibited, in particular, from using their knowledge of insider information (Section 14 para 1 German Securities Trading Act – Wertpapierhandelsgesetz) to sell the shares they subscribed through the exercise of their option rights.


  

	(2)	The Optionee undertakes hereby to acknowledge and comply with the internal guidelines on avoiding insider trading violations that the Company has issued or will issue in the future.
Any breach of these guidelines constitutes a violation of collateral duties under labor law, which might give the Company the right to terminate the Optionee effective immediately. 

 § 16 
 Non-Obligation Clause

 Option rights are granted with the proviso that such granting is voluntary and does not give rise to any legal claim to the granting of option rights
in the future, even if option rights are granted repeatedly. 
  

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 § 17 
 Exercise Agent 
 The Company’s Management shall serve as the exercise agent. The Company authorizes its legal
department to accept subscription notices and to execute the exercise procedure. The Company is authorized to engage a fiduciary agent (e.g. a bank) to take over these duties from the Management or Supervisory Board and serve as the exercise agent.

 § 18 
 Notifications 
 Notices, communications, changes, or modifications pertaining to the option rights shall be made known to the Optionee in
writing. Legally binding written notifications (e.g. termination notices and so forth) shall be delivered to the Optionee in person against receipt or by registered mail or courier to the last address provided by the Optionee to the Company or its
affiliate(s). 
 § 19 
 Concluding Provisions 
  

	(1)	If individual provisions of the present option terms are or become fully or partially ineffective or unenforceable, the effectiveness of the remaining provisions thereof shall not
be affected thereby. The ineffective or unenforceable provisions shall be replaced by provisions that come as close as possible to the economic purpose of the unenforceable provisions in a legally permissible manner. The same shall apply analogously
to any lacunae requiring amendment that become evident in the implementation of the present option terms. 

  

	(2)	Modifications of and amendments to the present terms shall be made in writing, to the extent that they need not be notarized. The preceding clause shall also apply to modifications
of the written form clause. 

  

	(3)	The Company’s domicile shall be the place of performance and jurisdiction. 

  

	(4)	The form and content of both the option rights and the rights and duties of the Optionee and the Company are subject to the laws of the Federal Republic of Germany.


  

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 Martinsried/Planegg, Germany,
                                 
 The Management Board of 
 GPC Biotech AG 
  

	
	Acknowledged:
	
	   
	(                                      
                                  )


  

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