1 

## EXPOSURE CHARACTERIZATION

FOR

Ethylene glycol diethyl ether (CASRN: 629-14-1) Ethane, 1,2-diethoxy-

November 6, 2009

Prepared by

Exposure Assessment Branch Chemical Engineering Branch Economics, Exposure and Technology Division
Office of Pollution Prevention and Toxics Environmental Protection Agency

1200 Pennsylvania Avenue, NW

Washington, DC 20460-00012 

## Exposure Characterization
Ethane, 1,2-diethoxy- (CASRN: 629-14-1)

Production Volume, Use, and Release Information

Ethane, 1,2-diethoxy- (CASRN 629-14-1) had an a ggregated production and/ or import volume in
the United States of less than 500,000 pounds in calendar year 2005.

No industrial processing and uses were reported in the IUR for the chemical. No commercial and consumer uses were reported in the IUR fo r the chemical. The Hazardous Substances Data Bank (HSDB) for ethane, 1,2-dietho xy- (CASRN 629-14-1) states that the chemical is primarily used as an inert reaction medium; a diluent for detergents; or a solvent for ester gum, shellac, and
some resins and oils. 1

Based on use information, there is potential for e nvironmental releases to water, land, and/or air during manufacturing, processing, and/or use. This chemical is reported as part of the Ethylene Glycol category in TRI, but not individually. The total release reported in the 2007 TRI from all reporting sites is 18,476,420 pounds for the chemicals in this category.

Exposure Characterization Summary

EPA identifies a medium potential that the ge neral population and the environment might be exposed to chemicals in this category based on known uses and reported TRI releases.

EPA identifies a low relative ra nking for this chemical for pot ential worker exposure based primarily on reported IUR production volumes, us e information and the number of workers potentially exposed.

EPA identifies a high potential that consumers might be exposed to this chemical based on use in consumer products. The Source Ranking Database indicates that this chemical is found in consumer products.

EPA identifies a medium potential that children might be exposed to this chemical through household use of some consumer products based on IUR and other data sources. No uses in products specifically intended to be used by childr en were reported in these data sources.

1 HSDB, 2008. Hazardous Substances Data Bank. Accessed, 08/26/2009, Ethylene glycol (CASRN: 629-14-1). http://toxnet.nlm.nih.gov/3 

## Appendix B: Screening Level Exposure Characterization

Ethylene glycol diethyl ether (CASRN: 629-14-1)Ethane, 1,2-diethoxyThis exposure characterization was completed using both public, non-conf idential sources, and one or more IUR submissions that were available as of this writing.

Volume and Use Information

This chemical had an aggregated production an d/or import volume in the United States of less than 500,000 pounds in calendar year 2005. 2 Non-confidential information in the IUR indicates
that this chemical was manufactur ed and/or imported at the follo wing companies and sites: Ferro Corporation (Zachary, LA). There may be ot her companies and sites that are claimed confidential. Persons submitting IUR informati on for 2005 asserted that some or all of the information was confidential. Only non-confidentia l versions of reported IUR data are included in this summary.

No industrial processing and uses or commercial/consumer uses are reported in IUR
submissions.

The Hazardous Substances Data Bank (HSDB) for this chemical states that the chemical is primarily used as an inert reaction medium; a diluent for detergents; or a solvent for ester gum, shellac, a solvent for ester gum, shellac, and some resins and oils. 3

Environmental Releases

Environmental releases may impact general pop ulation and environmental exposures. Factors affecting releases include volumes produced, processed and used; numbers of sites; and processes of manufacture, processing, and use.

Based on IUR data, the maximum total number of industrial sites manufacturing, processing, or using this chemical is less than 100.

The following release statements are made base d on inferences regarding the non-confidential use information reported in public data sources.

Chemicals with unknown industrial use can have va riable release percen tages during industrial processing and use. The actual percentage and quantity of release of the reported chemical
associated with this ca tegory are not known.

2 USEPA, 2006. Inventory Update Reporting Database. Version 1.03

3 HSDB, 2008. Hazardous Substances Data Bank. Accessed, 08/26/2009, Ethylene glycol (CASRN: 629-14-1). http://toxnet.nlm.nih.gov/4 The chemical is on the Toxics Releas e Inventory, as part of a category. 4 Chemicals in this category are reported as “certain glycol ethers” under the CAS number N230. The total release reported in 2007 from all reporting sites is 18,476, 420 pounds. This total includes air releases of 16,416,033 pounds from on-site fugitive and point source s, in addition to on-site water releases of 87,035 pounds. Most of the remaining volume of release was deep-well injected, sent to land treatment, transferred for energy recovery or transferred to a POTW. Releases of individual chemicals in this category are not known.

Table 1. Summary of TRI Releases
Company Name, Site Location Total Releases from Site (lb/yr)
EQ DETROIT INC, 1923 FREDERICK, DETROIT , WAYNE, MI 661,058

BALL METAL BEVERAGE CONTAINER CORP, 8935 POCAHONTAS TRAIL JAMES RIVER COMMERCE CENTER, WILLIAMSBURG , JAMES CITY, VA 359,000

REXAM BEVERAGE CAN CO RE: WINSTON SALEM PLANT, 4000 OLD MILWAUKEE LN, WINSTON-SALEM , FORSYTH,
NC 344,746

CHRYSLER ST. LOUIS NORTH ASSEMBLY PLANT, 1050 DODGE DR, FENTON , ST LOUIS, MO 336,011

BALL METAL BEVERAGE CONTAINER CORP, 12340 TOWNSHIP RD 99 E, FINDLAY , HANCOCK, OH 308,000

WHIRLPOOL CORP MARION D IVISION, 1300 MARIONAGOSTA RD, MARION , MARION, OH 256,184

SANYO SOLAR (USA) LLC, 970 E 236TH ST, CARSON , LOS ANGELES, CA 242,783

REXAM BEVERAGE CAN CO RE: FREMONT PLANT, 2145 CEDAR, FREMONT , SANDUSKY, OH 239,200

REXAM BEVERAGE CAN CO RE: WHITEHOUSE PLANT, 10444 WATERVILLE, WHITEHOUSE , LUCAS, OH 209,963

CROWN CORK & SEAL CO (USA) INC CROWN CLOSURE DIV, 3011 BIRCH DR, WEIRTON , BROOKE, WV 202,266

REXAM BEVERAGE CAN CO OLIVE BRANCH FACILITY, 10800 MARINA DR, OLIVE BRANCH , DESOTO, MS 189,816

REXAM BEVERAGE CAN CO KENT WA FACILITY, 1220 N SECOND AVE, KENT , KING, WA 184,587

REXAM BEVERAGE CAN CO RE: BISHOPVILLE SC FACILITY, 609 COUSAR ST, BISHOPVILLE , LEE, SC 180,079

REXAM BEVERAGE CAN CO RE: EVA STREET ST PAUL MN, 139 EVA ST, SAINT PAUL , RAMSEY, MN 178,827

REXAM BEVERAGE CAN CO LONGVIEW FACILITY, 1001 FISHER RD, LONGVIEW , GREGG, TX 171,826

BALL METAL BEVERAGE CONTAINER CORP, 1900 BARNES ST, REIDSVILLE , ROCKINGHAM, NC 168,000

REXAM BEVERAGE CAN CO RE FOREST PARK FACILITY, 48 ROYAL DR, FOREST PARK , CLAYTON, GA 160,841

REPUBLIC ENGINEERED PRODU CTS INC. LORAIN PLANT, 1807 E 28TH ST, LORAIN , LORAIN, OH 160,001

BALL METAL BEVERAGE CONTAINER CORP, 8500 W TOWER AVE, MILWAUKEE , MILWAUKEE, WI 159,800

BMW MANUFACTURING CO LLC, 1400 HWY 101 S, GREER , SPARTANBURG, SC 159,730

Releases Grand Total 18,530,224 Source: TRI for 2007 from TriExplorer. Note: only sites with top 20 releases were included in the list. Total rel ease includes all reporting sites.

This chemical has a vapor pressure of 33.7 mmHg at 25oC. Experience has shown that air
releases due to volatilization ha ve not been an issue for chemicals with vapor pressures below

4 USEPA, 2007. Toxic Release Inventory. Accessed, 9/3/09. http://www.epa.gov/triexplorer/

.5 0.01 mm Hg. This chemical’s vapor pressure indicates poten tial for air releases from
volatilization.

Exposures to the General Population and the Environment

Based on the available informati on under the release section above, it is likely that there would be some releases to water, land, and/or air du ring manufacturing, processing, and use. A search
of additional relevant database s did not provide any further information on releases of this
chemical.

This chemical is included in the STORET. 5 Potential exposure to the general population, environment, and children is likely from this ch emical found in ground water or surface water.

Persistence and bioaccumulation ratings for this chemical are P2 and B1. 6 These ratings suggest that this chemical is persistent in the environm ent; and is not bioaccumulative. This chemical is expected to possess moderate to high water solub ility and high mobility in soil. The rate of hydrolysis is considered negligib le and volatilization is considered low to moderate based on the estimated Henry’s Law constants.

Based on the information considered, including environmental fate, known uses, reported TRI releases, and the Agency’s expert judgment, EPA identifies, for purposes of risk-based prioritization, a medium potenti al that the general population and the environment might be exposed to chemicals in this category.

Exposures to Workers

Worker exposures may be impacted by many f actors, including but not limited to volumes produced, processed and used; physical forms an d concentrations; processes of manufacture, processing, and use; chemical volat ility, and exposure controls, such as engineering controls and personal protective equipment.

Based on IUR data, the maximum total number of workers reasonably likel y to be exposed to this chemical during manufacturing and industr ial processing and use may be less than 100. There may be additional potentially exposed indu strial workers who are not included in this
estimate. This estimate does not include potentially exposed commercial workers.

The National Occupational Exposure Survey (NOE S) has no data for total number of workers potentially exposed to this chem ical under the CAS number 629-14-1. 7

Based on IUR data, this chemical is manufactured in liquid forms, and worker exposures through dermal contact are possible for ch emicals in these forms. There may be other physical forms that are claimed confidential. Physi cal and chemical property informa tion indicates that the physical

5 USEPA , 2008. STORET. Accessed, 02/1 2/08. http://www .epa.gov/storet/

6 USEPA, 2009. Screening-Level Hazard Characterization for High Production Volume Chemicals, Glycol Ethers.

August 2009.

7 NIOSH, 1983. National Occupational Exposure Surv ey (NOES, 1981-1983). Accessed, 05/14/2008.

http://www.cdc.gov/noes/6 state of the pure chemical is liq uid. Also, the non-confidential maximum concentration is up to 100%. There may be other concentrations that are claimed confidential.

This chemical has a vapor pr essure of 33.7 mm Hg at 25oC. 8 Experience has shown that worker inhalation exposures to vapors have not been an issue for chemi cals with vapor pressures below 0.001 mm Hg. This chemical’s va por pressure could result in wo rker inhalation exposures to vapors if workers are near to the open liquid.

This chemical does not have OSHA Permissible Exposure Limits (PELs) 9

.

None of the uses indicate an obvious potential for inhalation exposure.

Based on all available information, workers may be exposed by the dermal route. Although the
TRI indicates air releases , it is not known whether workers ar e exposed to this chemical by the
inhalation route.

EPA identifies, for the purposes of risk-based prioritization, a low rela tive ranking for potential worker exposure based on a low PV (<500,000 pounds), less than 100 workers potentially exposed, and the Agency’s professional judgment. In addition, little info rmation on the uses of these chemicals is available and the potenti al for worker exposure is uncertain.

Exposures to Consumers

There were no reported consumer uses in th e 2006 IUR submissions for this chemical.

There is also potential for exposur e to consumers based on informati on from public data sources.

This chemical was listed in the Source Ranki ng Database (SRD), which indicates that these
chemicals were contained in one or more consumer products. 10 There is potential that consumers and children might be exposed to this chemical from consumer products containing this
chemical.

EPA identifies, for the purposes of risk-based prioritization, a high pot ential that consumers might be exposed to this chemical based on the us e of products containing this chemical reported in public data sources.

Exposures to Children

This chemical was found in consumer products. EP A identifies a medium potential that children might be exposed to this chemical through hous ehold use of some cons umer products based on

8 USEPA, 2009. Screening-Level Hazard Characterization fo r High Production Volume Chemicals, Glycol Ethers. August 2009.

9 OSHA, 2009. Occupational Safety and Health Administ ration (OSHA) Permissible Exposure Limits (PELs).

http://www.osha.gov/S LTC/pel/recognition.html . Accessed, 09/01/2009.

10 US EPA, 2008. Source Ranking Database (SRD). Accessed, 05/19/08. http://www.epa.gov/opptintr/exposure/pubs/srd.htm

.7 IUR and other data sources. No uses in produc ts specifically intended to be used by children were reported in these data sources.2 Non Confidential 2006 IUR Data Summary

CASRN 629-14-1

Manufacturing/Import Information

Production and import volume: <500,000 pounds 1998: No reports found 2002: No reports found

List of non-CBI companies/ sites*: Ferro Corporation

Maximum number of industrial sites**: 1 to 99

Maximum number of industrial workers**: 1 to 99

Highest non-CBI maximum concentration*: Greater than 90%

Non-CBI physical forms*: Liquid

* There may be other companies/sites, concentrations a nd physical forms that are claimed confidential. ** Includes all manufacturing and industrial processing and use sites and workers. There may be additional industrial
sites and workers that are not included in this estimate si nce not all submitters were re quired to report on industrial processing and use and/or there may be at least one use th at contains a "Not Readily Obtainable" (NRO) response among the submissions.

Table 1 Industrial Processing and Use Information Processing Activity Industrial
Sector Function in
Industrial Sector None reported

Table 1 Notes:
1. The combined total volume of all CBI and non-CBI i ndustrial processing and use activities reported to IUR in 2006
account for ≤ 20% of the aggregate national production and/or import volume. 11 2. The total non-CBI industrial processing and u se activities reported to IUR in 2006 account for ≤ 20% of the aggregate national production and/or import volume.

Table 2
Commercial/Consumer Use Information
Commercial/ Consumer Product Category Description Highest Maximum Concentration Range Use in Children’s Products

None reported

11 USEPA, 2006. Inventory Update Reporting Database. Version 1.033 

## ATTACHMENT 1:
NON-CBI DATA AND INFORMATION DETAILS

Public Databases Search (CASRN 629-14-1)

Table 1-7. Summary of Public Databa se Search Finding s (CASRN 629-14-1)

Data Source Descriptive Statement (Standard Drop-in Language) Yes/ No

Children’s Total Exposure to Persistent Pesticides and Other Persistent Organic Pollutants (CTEPP) Study, U.S. EPA; Accessed: 05/19/08. http://www.epa.gov/heasd/ctepp/index.htm Potential exposure to children from this commonly used household chemical is likely. NO

Contaminant Exposure an d Effects-Terrestrial Vertebrates database (CEE-TV); Accessed: 05/19/08.http://www.pwrc.usgs.gov/contaminantsonline/pages/CEETV/CEETVintro.htm Potential exposure to the general population and the environment, from this chemical found in
terrestrial vertebrates in estuarine and coastal habitats is likely. NO

Current National Recommended Water Quality Criteria, U.S. EPA; Accessed: 05/14/08. http://www.epa.gov/waterscience/criteria/wqcriteria.h
tml Potential exposure to this chemical that may exceed recommended water quality criteria for general population and the environment is likely. NO

EPA Environmental Monitoring and Assessment Program (EMAP), Accessed: 05/19/08. http://www.epa.gov/emap/index.html Potential exposure to the environment from this chemical chosen by EMAP as an ecological indicator for the ecological condition of the aquatic environment. NO

Everything Added to Food in the United States (EAFUS), U.S. FDA; Accessed: 05/19/08 http://vm.cfsan.fda.gov/~dms/eafus.html Potential exposure to the general population and children is likely for this chemical that has been identified as a food additive by USFDA. NO

Indoor Air Articles [Articles published by Brown et al. (1994), Daisey et al. (1994), Immerman and Schaum (1990), Samfield (1992), Shah et al. (1988), Sheldon et al. (1992), and Shields et al. (1996)]. Potential exposure to the general population and children from this chemical in indoor air is likely. NO

List of Drinking Water Contaminants and their Maximum Contaminant Levels (MCLs); Accessed:
05/20/08. http://www.epa.gov/safewate r/contaminants/index.ht
ml#mcls see also http://www.access.gpo.gov/nara/cfr/waisidx_02/40cfr 141_02.html Potential exposure to this Safe Drinking Water Act chemical for the general population and children is likely. NO

National Air Quality System (AQS), U.S. EPA Office of Air and Radiation; Accessed: 05/15/08. http://www.epa.gov/aqspubl1/select.html Potential exposure to the general population, environment, and children is likely for this National Air Monitoring System criteria air pollutant. NO4 Table 1-7. Summary of Public Databa se Search Finding s (CASRN 629-14-1)

Data Source Descriptive Statement (Standard Drop-in Language) Yes/ No

National Contaminant Occurrence Database (NCOD), U.S. EPA; Accessed: 05/19/08. http://www.epa.gov/safewate r/data/ncod/index.html Potential exposure to the general population, environment, and children is likely for this contaminant found in drinking water. NO

National Emission Inventory (NEI) Database, U.S. EPA; Accessed: 05/14/08. http://www.epa.gov/ttn/chief/net/ Potential exposure to the general population, environment, and children is likely from this
chemical found in the air as a point, non-point or
mobile source. NO

National Fish Tissue Study, U.S. EPA Office of Science and Technology; Accessed: 05/19/08. http://www.epa.gov/waterscience/fishstudy/overview.
htm Potential exposure for the general population and children is likely to this chemical in fish tissue
from lakes and reservoirs of the continental US. NO

National Health and Nutrition Examination Survey (NHANES), Center for Disease Control; Accessed:
02/12/08. http://www.cdc.gov/nchs/nhanes.htm Potential exposure to the general population, environment, and children is likely for this
chemical included in a st udy that evaluates how environmental exposures function as risk factors
for disease. NO

National Human Adipose Tissue Survey (NHATS), U.S. EPA Office of Pollution Prevention and Toxics;
Accessed: 05/19/08. http://cfpub.epa.gov/ncea/cf m/recordisplay.cfm?deid=
55204 Potential exposure to the general population and children is likely from this chemical that was found in a study of human adipose tissue. NO

National Human Exposure Assessment Survey (NHEXAS), U.S. EPA National Exposure Research Laboratory; Accessed: 02/12/08. http://www.epa.gov/heasd/edrb/nhexas.htm Potential exposure to the general population, environment, and children is likely from this
chemical that was incl uded in a community/ regional scale study to determine the association between exposure and daily activities. NO

National Occupational Exposure Survey (NOES);
Accessed: 05/14/2008. http://www.cdc.gov/noes/ Edit paragraph in Appendix B worker section according to findings. If Yes, include # of
workers in next cell: NO

National Sediment Inventory (NSI) Tissue Data, U.S. EPA Office of Water; Accessed: 05/16/08. http://www.epa.gov/waterscience/cs/nsidbase.html Potential exposure to the general population and the environment is likely from this chemical
found in sediments. NO

National Status and Trends Program (NSTP) National Oceanic and Atmospheric Ad ministration; Accessed:
05/19/08. http://nsandt.noaa.gov/nsandt_overview.htm Potential exposure to the general population and the environment is likely from this chemical found in aquatic life in estuarine and coastal
waters of the US. NO

National Stream Quality Accounting Network (NASQAN) Surface Water and Sediment Data, U.S.G.S.; Accessed: 05/16/08. http://water.usgs.gov/nasqan/progdocs/wri014255/res
ults/data.htm Potential exposure to the general population, environment, and children is likely from this chemical found in one of the nation’s four largest river systems: the Mississippi, the Columbia, the
Colorado or the Rio Grande. NO

National Water Quality Assessment (NAWQA) Program; Accessed: 02/12/08. http://infotrek.er.usgs.gov/servlet/page?_pageid=543 &_dad=portal30&_schema=PORTAL30 Potential exposure to the general population, environment, and children is likely from this chemical found in ground water. NO5 Table 1-7. Summary of Public Databa se Search Finding s (CASRN 629-14-1)

Data Source Descriptive Statement (Standard Drop-in Language) Yes/ No

Permit Compliance System (PCS), U.S. EPA;
Accessed: 02/12/08. http://www.epa.gov/enviro/ Potential exposure to the general population, environment, and children is likely from this chemical monitored at discharge points through NPDES permits. NO

Section 21 Petition regarding chemicals in air
fresheners Potential exposure to consumers and children is likely from this chemical th at is contained in air
fresheners. NO

Source Ranking Database (SRD); Accessed:
05/19/08. http://www.epa.gov/opptintr/exposure/pubs/srd.htm This chemical was listed in the Source Ranking Database (SRD), which indicates that this
chemical was contained in one or more consumer products. There is potential that consumers and children might be exposed to this chemical from consumer products containing this chemical. YES

STORET, U.S. EPA Office of Water; Accessed:
02/12/08. http://www.epa.gov/storet/ Potential exposure to the general population, environment, and children is likely from this chemical found in ground water or surface water. YES

Total Exposure Assessment Methodology (TEAM), U.S. EPA; Accessed: 02/12/08. Potential exposure to the general population, environment, and children is likely from this
chemical measured in humans. NO

Voluntary Children’s Chemical Evaluation Program (VCCEP), U.S. EPA; Accessed: 10/17/08 http://www.epa.gov/oppt/vccep/pubs/vcceprsp.pdf Potential exposure to the general population, environment, and children is likely from this chemical covered under a voluntary USEPA pilot program investigating chemicals with a high likelihood of exposure to children. NO

Sources with Additional Information Hazardous Substances Data Bank (HSDB) http://toxnet.nlm.nih.gov/ Summarize in appropriate section after this table YES

High Production Volume (HPV) Challenge Submission contains Use and Exposure Information http://cfpub.epa.gov/hpv%2Ds/ Summarize in appropriate section after this table NO

Extended High Production Volume Program (EHPV), U.S. EPA; Accessed: 12/03/08.

http://www.regulations.gov /fdmspublic/component/m
ain?main=DocketDeta il&d=EPA-HQ-OPPT-2006-
1020 Summarize in appropriate section after this table NO

National Institute of Health’s (NIH) Household
Products Database http://hpd.nlm.nih.gov/products.htm This chemical was listed in the NIH Household Products Database, which indicates that this
chemical was contained in one or more household products. There is potential that consumers and children might be exposed to this chemical from consumer products containing this chemical. NO

Preliminary Assessment Information Rule (PAIR); TSCA Section 8(a) PAIR information is confidential. NO6 Table 1-7. Summary of Public Databa se Search Finding s (CASRN 629-14-1)

Data Source Descriptive Statement (Standard Drop-in Language) Yes/ No

Screening Information Data Set (SIDS) documents contains Use and Exposure Information http://www.chem.unep.ch/irptc/sids/oecdsids/sidspub.
html Summarize in appropriate section after this table NO

Toxic Release Inventory (TRI), U.S. EPA http://www.epa.gov/tri/ Summarize in appropriate section after this table NO

OSHA PEL: http://www.osha.gov/SLTC /pel/recognition.html Note: edit statement in Appendix B worker section and if Yes, include PEL in next cell: NO

ACGIH TLVs and BEIs. 2009. Note: edit statement in Appendix B worker section and if Yes, include TLV in next cell: NO

NIOSH Pocket Guide to Chemical Hazards. http://www.cdc.gov/NIOSH/npg/npgdcas.html Note: edit statement in Appendix B worker section and if Yes, include REL in next cell: NO

HPV Submission Use and Exposure Information Summary

No HPV submission was found.

EHPV Submission Use and Exposure Information Summary

No EHPV submission was found.

HSDB Use and Exposure Information Summary

Skin, Eye and Respiratory Irritations: Ethylene glycol diethyl ether vapor is irrita ting to the eyes and mucous membranes. [Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V7 176] **PEER REVIEWED**

Protective Equipment & Clothing: Protective goggles or face shield; rubber gloves. [U.S. Coast Guard, Department of Transporta tion. CHRIS - Hazardous Chemical Data. Manual Two. Washington, DC: U.S. Government Prin ting Office, Oct., 1978.] **PEER REVIEWED**

Glove manufacturers have recomm ended gloves of neoprene or ni trile butyl rubber construction for protection against liquid ethy lene glycol diethyl ether. [Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens, 2002. 4th ed.Vol 1 A-H Norwich, NY: Noyes Publicati ons, 2002., p. 1091] **PEER REVIEWED**

Where the potential exists for exposure to ethylen e glycol diethyl ether, use a ...NIOSH approved7 supplied-air respirator with a full facepiece operate d in the positive pressure mode or with a full facepiece, hood, or helmet in the continuous flow mode, or use a NIOSH approved selfcontained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode. [Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens, 2002. 4th ed.Vol 1 A-H Norwich, NY: Noyes Publicati ons, 2002., p. 1091] **PEER REVIEWED**

Personnel protection: ... Wear appr opriate chemical protective gl oves, boots and goggles. Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. [Association of American Railroads; Bureau of Explosives. Emergency Handling of Hazardous Materials in Surface Transportation. Associati on of American Railroads, Pueblo, CO. 2005, p. 403] **PEER REVIEWED**

Major Uses:
INERT REACTION MEDIUM
**PEER REVIEWED**

SOLVENT FOR ESTER GUM, SHELLAC AN D SOME RESINS AND OILS [Browning, E. Toxicity and Metabolism of Indus trial Solvents. New York: American Elsevier, 1965., p. 612] **PEER REVIEWED**

Organic synthesis (reaction medium), so lvent and diluent for detergents [Lewis, R.J. Sr.; Hawley's Condensed Chemi cal Dictionary 14th Edition. John Wiley & Sons, Inc. New York, NY 2001., p. 465] **PEER REVIEWED**

Dye solvents in non-grain raising stains [Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. V21 484] **PEER REVIEWED**

SIDS Document Use and Exposure Information Summary

No SIDS documents were found for this chemical.

TRI Release Data Summary

This chemical is reported under the category “certain glycol ethers” in TRI under the CAS
number N230. Refer to Table 2-2.

MSDS Summary Information

A material safety data sheet (MSDS), from Alfa Aesar, 12 provides some information about the safety of the chemical includi ng hazards, accidental release m easures, handling and storage, exposure controls/personal prot ective equipment, toxicologica l information, disposal and transport information. This MSDS was pr ovided to EPA in a separate PDF file: MSDS 629-14- 1.pdf. This MSDS was downloaded from the Internet and serves as an example MSDS only.

12 Alfa Aesar, 2008. Material Safety Data Sheet for 1,2 - diethoxyethane and CASRN# 629-14-1. Accessed,
8/26/2009. http://www.alfa.com/content/msds/USA/L14283.pdf8 EPA has not reviewed the MSDS information nor does it endorse the company, the product, or
the use of the MSDS information.

General Equipment: Impervious gloves, safety gl asses/tightly sealed goggles.

Respirator: Use a suitable respirator when high concentrations are present.

Health Effects: Irritant to skin and respiratory system; strong irritant with danger of severe eye injury; possible risk of harm to the unborn child.