1 

EXPOSURE CHARACTERIZATION 

FOR 

Ethylene glycol diethyl ether (CASRN: 629-14-1) 

Ethane, 1,2-diethoxy- 

 November 6, 2009 

Prepared by 

Exposure Assessment Branch 

Chemical Engineering Branch 

Economics, Exposure and Technology Division 

Office of Pollution Prevention and Toxics 

Environmental Protection Agency 

1200 Pennsylvania Avenue, NW 

Washington, DC 20460-0001
2 

 Exposure Characterization 

Ethane, 1,2-diethoxy- (CASRN: 629-14-1) 

Production Volume, Use, and Release Information

Ethane, 1,2-diethoxy- (CASRN 629-14-1) had an aggregated production and/or import volume in 

the United States of less than 500,000 pounds in calendar year 2005. 

No industrial processing and uses were reported in the IUR for the chemical. No commercial 

and consumer uses were reported in the IUR for the chemical. The Hazardous Substances Data 

Bank (HSDB) for ethane, 1,2-diethoxy- (CASRN 629-14-1) states that the chemical is primarily 

used as an inert reaction medium; a diluent for detergents; or a solvent for ester gum, shellac, and 

some resins and oils.1

Based on use information, there is potential for environmental releases to water, land, and/or air 

during manufacturing, processing, and/or use. This chemical is reported as part of the Ethylene 

Glycol category in TRI, but not individually. The total release reported in the 2007 TRI from all 

reporting sites is 18,476,420 pounds for the chemicals in this category. 

Exposure Characterization Summary

EPA identifies a medium potential that the general population and the environment might be 

exposed to chemicals in this category based on known uses and reported TRI releases. 

EPA identifies a low relative ranking for this chemical for potential worker exposure based 

primarily on reported IUR production volumes, use information and the number of workers 

potentially exposed. 

EPA identifies a high potential that consumers might be exposed to this chemical based on use in 

consumer products. The Source Ranking Database indicates that this chemical is found in 

consumer products. 

EPA identifies a medium potential that children might be exposed to this chemical through 

household use of some consumer products based on IUR and other data sources. No uses in 

products specifically intended to be used by children were reported in these data sources. 

 

1

 HSDB, 2008. Hazardous Substances Data Bank. Accessed, 08/26/2009, Ethylene glycol (CASRN: 629-14-1). 

http://toxnet.nlm.nih.gov/ 
3 

Appendix B: Screening Level Exposure Characterization 

Ethylene glycol diethyl ether (CASRN: 629-14-1) 

Ethane, 1,2-diethoxyThis exposure characterization was completed using both public, non-confidential sources, and 

one or more IUR submissions that were available as of this writing. 

Volume and Use Information

This chemical had an aggregated production and/or import volume in the United States of less 

than 500,000 pounds in calendar year 2005.2

 Non-confidential information in the IUR indicates 

that this chemical was manufactured and/or imported at the following companies and sites: Ferro 

Corporation (Zachary, LA). There may be other companies and sites that are claimed 

confidential. Persons submitting IUR information for 2005 asserted that some or all of the 

information was confidential. Only non-confidential versions of reported IUR data are included 

in this summary. 

No industrial processing and uses or commercial/consumer uses are reported in IUR 

submissions. 

The Hazardous Substances Data Bank (HSDB) for this chemical states that the chemical is 

primarily used as an inert reaction medium; a diluent for detergents; or a solvent for ester gum, 

shellac, a solvent for ester gum, shellac, and some resins and oils.3

Environmental Releases

Environmental releases may impact general population and environmental exposures. Factors 

affecting releases include volumes produced, processed and used; numbers of sites; and 

processes of manufacture, processing, and use. 

Based on IUR data, the maximum total number of industrial sites manufacturing, processing, or 

using this chemical is less than 100. 

The following release statements are made based on inferences regarding the non-confidential 

use information reported in public data sources. 

Chemicals with unknown industrial use can have variable release percentages during industrial 

processing and use. The actual percentage and quantity of release of the reported chemical 

associated with this category are not known. 

 

2

 USEPA, 2006. Inventory Update Reporting Database. Version 1.03 

3

 HSDB, 2008. Hazardous Substances Data Bank. Accessed, 08/26/2009, Ethylene glycol (CASRN: 629-14-1). 

http://toxnet.nlm.nih.gov/ 
4 

The chemical is on the Toxics Release Inventory, as part of a category.4 Chemicals in this 

category are reported as “certain glycol ethers” under the CAS number N230. The total release 

reported in 2007 from all reporting sites is 18,476,420 pounds. This total includes air releases of 

16,416,033 pounds from on-site fugitive and point sources, in addition to on-site water releases 

of 87,035 pounds. Most of the remaining volume of release was deep-well injected, sent to land 

treatment, transferred for energy recovery or transferred to a POTW. Releases of individual 

chemicals in this category are not known. 

Table 1. Summary of TRI Releases 

Company Name, Site Location Total Releases from Site (lb/yr) 

EQ DETROIT INC, 1923 FREDERICK, DETROIT , WAYNE, MI 661,058 

BALL METAL BEVERAGE CONTAINER CORP, 8935 

POCAHONTAS TRAIL JAMES RIVER COMMERCE CENTER, 

WILLIAMSBURG , JAMES CITY, VA

359,000 

REXAM BEVERAGE CAN CO RE: WINSTON SALEM PLANT, 

4000 OLD MILWAUKEE LN, WINSTON-SALEM , FORSYTH, 

NC

344,746 

CHRYSLER ST. LOUIS NORTH ASSEMBLY PLANT, 1050 

DODGE DR, FENTON , ST LOUIS, MO

336,011 

BALL METAL BEVERAGE CONTAINER CORP, 12340 

TOWNSHIP RD 99 E, FINDLAY , HANCOCK, OH

308,000 

WHIRLPOOL CORP MARION D IVISION, 1300 MARIONAGOSTA RD, MARION , MARION, OH

256,184 

SANYO SOLAR (USA) LLC, 970 E 236TH ST, CARSON , LOS 

ANGELES, CA

242,783 

REXAM BEVERAGE CAN CO RE: FREMONT PLANT, 2145 

CEDAR, FREMONT , SANDUSKY, OH

239,200 

REXAM BEVERAGE CAN CO RE: WHITEHOUSE PLANT, 10444 

WATERVILLE, WHITEHOUSE , LUCAS, OH

209,963 

CROWN CORK & SEAL CO (USA) INC CROWN CLOSURE DIV, 

3011 BIRCH DR, WEIRTON , BROOKE, WV

202,266 

REXAM BEVERAGE CAN CO OLIVE BRANCH FACILITY, 

10800 MARINA DR, OLIVE BRANCH , DESOTO, MS

189,816 

REXAM BEVERAGE CAN CO KENT WA FACILITY, 1220 N 

SECOND AVE, KENT , KING, WA

184,587 

REXAM BEVERAGE CAN CO RE: BISHOPVILLE SC FACILITY, 

609 COUSAR ST, BISHOPVILLE , LEE, SC

180,079 

REXAM BEVERAGE CAN CO RE: EVA STREET ST PAUL MN, 

139 EVA ST, SAINT PAUL , RAMSEY, MN

178,827 

REXAM BEVERAGE CAN CO LONGVIEW FACILITY, 1001 

FISHER RD, LONGVIEW , GREGG, TX

171,826 

BALL METAL BEVERAGE CONTAINER CORP, 1900 BARNES 

ST, REIDSVILLE , ROCKINGHAM, NC

168,000 

REXAM BEVERAGE CAN CO RE FOREST PARK FACILITY, 48 

ROYAL DR, FOREST PARK , CLAYTON, GA

160,841 

REPUBLIC ENGINEERED PRODUCTS INC. LORAIN PLANT, 

1807 E 28TH ST, LORAIN , LORAIN, OH

160,001 

BALL METAL BEVERAGE CONTAINER CORP, 8500 W TOWER 

AVE, MILWAUKEE , MILWAUKEE, WI

159,800 

BMW MANUFACTURING CO LLC, 1400 HWY 101 S, GREER , 

SPARTANBURG, SC

159,730 

Releases Grand Total 18,530,224 

 Source: TRI for 2007 from TriExplorer. 

 Note: only sites with top 20 releases were included in the list. Total release includes all reporting sites. 

This chemical has a vapor pressure of 33.7 mmHg at 25oC. Experience has shown that air 

releases due to volatilization have not been an issue for chemicals with vapor pressures below 

 

4 USEPA, 2007. Toxic Release Inventory. Accessed, 9/3/09. http://www.epa.gov/triexplorer/.
5 

0.01 mm Hg. This chemical’s vapor pressure indicates potential for air releases from 

volatilization. 

Exposures to the General Population and the Environment 

Based on the available information under the release section above, it is likely that there would 

be some releases to water, land, and/or air during manufacturing, processing, and use. A search 

of additional relevant databases did not provide any further information on releases of this 

chemical. 

This chemical is included in the STORET.5

 Potential exposure to the general population, 

environment, and children is likely from this chemical found in ground water or surface water. 

Persistence and bioaccumulation ratings for this chemical are P2 and B1.6

 These ratings suggest 

that this chemical is persistent in the environment; and is not bioaccumulative. This chemical is 

expected to possess moderate to high water solubility and high mobility in soil. The rate of 

hydrolysis is considered negligible and volatilization is considered low to moderate based on the 

estimated Henry’s Law constants. 

Based on the information considered, including environmental fate, known uses, reported TRI 

releases, and the Agency’s expert judgment, EPA identifies, for purposes of risk-based 

prioritization, a medium potential that the general population and the environment might be 

exposed to chemicals in this category. 

Exposures to Workers 

Worker exposures may be impacted by many factors, including but not limited to volumes 

produced, processed and used; physical forms and concentrations; processes of manufacture, 

processing, and use; chemical volatility, and exposure controls, such as engineering controls and 

personal protective equipment. 

Based on IUR data, the maximum total number of workers reasonably likely to be exposed to 

this chemical during manufacturing and industrial processing and use may be less than 100. 

There may be additional potentially exposed industrial workers who are not included in this 

estimate. This estimate does not include potentially exposed commercial workers. 

The National Occupational Exposure Survey (NOES) has no data for total number of workers 

potentially exposed to this chemical under the CAS number 629-14-1.7

 

Based on IUR data, this chemical is manufactured in liquid forms, and worker exposures through 

dermal contact are possible for chemicals in these forms. There may be other physical forms that 

are claimed confidential. Physical and chemical property information indicates that the physical 

 

5

 USEPA, 2008. STORET. Accessed, 02/12/08. http://www.epa.gov/storet/ 6

 USEPA, 2009. Screening-Level Hazard Characterization for High Production Volume Chemicals, Glycol Ethers. 

August 2009. 7

 NIOSH, 1983. National Occupational Exposure Survey (NOES, 1981-1983). Accessed, 05/14/2008. 

http://www.cdc.gov/noes/ 
6 

state of the pure chemical is liquid. Also, the non-confidential maximum concentration is up to 

100%. There may be other concentrations that are claimed confidential. 

This chemical has a vapor pressure of 33.7 mm Hg at 25oC.8

 Experience has shown that worker 

inhalation exposures to vapors have not been an issue for chemicals with vapor pressures below 

0.001 mm Hg. This chemical’s vapor pressure could result in worker inhalation exposures to 

vapors if workers are near to the open liquid. 

This chemical does not have OSHA Permissible Exposure Limits (PELs) 9. 

None of the uses indicate an obvious potential for inhalation exposure. 

Based on all available information, workers may be exposed by the dermal route. Although the 

TRI indicates air releases, it is not known whether workers are exposed to this chemical by the 

inhalation route. 

EPA identifies, for the purposes of risk-based prioritization, a low relative ranking for potential 

worker exposure based on a low PV (<500,000 pounds), less than 100 workers potentially 

exposed, and the Agency’s professional judgment. In addition, little information on the uses of 

these chemicals is available and the potential for worker exposure is uncertain. 

Exposures to Consumers

There were no reported consumer uses in the 2006 IUR submissions for this chemical. 

There is also potential for exposure to consumers based on information from public data sources. 

This chemical was listed in the Source Ranking Database (SRD), which indicates that these 

chemicals were contained in one or more consumer products.10 There is potential that consumers 

and children might be exposed to this chemical from consumer products containing this 

chemical. 

EPA identifies, for the purposes of risk-based prioritization, a high potential that consumers 

might be exposed to this chemical based on the use of products containing this chemical reported 

in public data sources. 

Exposures to Children

This chemical was found in consumer products. EPA identifies a medium potential that children 

might be exposed to this chemical through household use of some consumer products based on 

 

8 USEPA, 2009. Screening-Level Hazard Characterization for High Production Volume Chemicals, Glycol Ethers. 

August 2009.

9

 OSHA, 2009. Occupational Safety and Health Administration (OSHA) Permissible Exposure Limits (PELs). 

http://www.osha.gov/SLTC/pel/recognition.html. Accessed, 09/01/2009. 10 US EPA, 2008. Source Ranking Database (SRD). Accessed, 05/19/08. 

http://www.epa.gov/opptintr/exposure/pubs/srd.htm. 
7 

IUR and other data sources. No uses in products specifically intended to be used by children 

were reported in these data sources. 
2 

Non Confidential 2006 IUR Data Summary

CASRN 629-14-1 

 Manufacturing/Import Information

 Production and import volume: <500,000 pounds

 1998: No reports found 

 2002: No reports found 

 List of non-CBI companies/sites*: Ferro Corporation 

 

 Maximum number of industrial sites**: 1 to 99 

 Maximum number of industrial workers**: 1 to 99 

 Highest non-CBI maximum concentration*: Greater than 90% 

 

 Non-CBI physical forms*: Liquid 

* There may be other companies/sites, concentrations and physical forms that are claimed confidential. 

** Includes all manufacturing and industrial processing and use sites and workers. There may be additional industrial 

sites and workers that are not included in this estimate since not all submitters were required to report on industrial 

processing and use and/or there may be at least one use that contains a "Not Readily Obtainable" (NRO) response 

among the submissions. 

Table 1 

Industrial Processing and Use Information 

Processing 

Activity 

Industrial 

Sector 

Function in 

Industrial Sector 

None reported 

Table 1 Notes: 

1. The combined total volume of all CBI and non-CBI industrial processing and use activities reported to IUR in 2006 

account for ≤20% of the aggregate national production and/or import volume. 11 

2. The total non-CBI industrial processing and use activities reported to IUR in 2006 account for ≤20% of the aggregate 

national production and/or import volume. 

Table 2 

Commercial/Consumer Use Information 

Commercial/ Consumer 

Product Category 

Description 

Highest Maximum 

Concentration Range 

Use in Children’s Products 

None reported 

 

11 USEPA, 2006. Inventory Update Reporting Database. Version 1.03 
3 

ATTACHMENT 1: 

NON-CBI DATA AND INFORMATION DETAILS 

Public Databases Search (CASRN 629-14-1) 

Table 1-7. Summary of Public Database Search Findings (CASRN 629-14-1) 

Data Source Descriptive Statement 

(Standard Drop-in Language) 

Yes/ No 

Children’s Total Exposure to Persistent Pesticides and 

Other Persistent Organic Pollutants (CTEPP) Study, 

U.S. EPA; Accessed: 05/19/08. 

http://www.epa.gov/heasd/ctepp/index.htm

Potential exposure to children from this 

commonly used household chemical is likely. NO 

Contaminant Exposure and Effects-Terrestrial 

Vertebrates database (CEE-TV); Accessed: 05/19/08. 

http://www.pwrc.usgs.gov/contaminantsonline/pages/CEETV/CEETVintro.htm

Potential exposure to the general population and 

the environment, from this chemical found in 

terrestrial vertebrates in estuarine and coastal 

habitats is likely. 

NO 

Current National Recommended Water Quality 

Criteria, U.S. EPA; Accessed: 05/14/08. 

http://www.epa.gov/waterscience/criteria/wqcriteria.h

tml

Potential exposure to this chemical that may 

exceed recommended water quality criteria for 

general population and the environment is likely. 

NO 

EPA Environmental Monitoring and Assessment 

Program (EMAP), Accessed: 05/19/08. 

http://www.epa.gov/emap/index.html

Potential exposure to the environment from this 

chemical chosen by EMAP as an ecological 

indicator for the ecological condition of the 

aquatic environment. 

NO 

Everything Added to Food in the United States 

(EAFUS), U.S. FDA; Accessed: 05/19/08 

http://vm.cfsan.fda.gov/~dms/eafus.html

Potential exposure to the general population and 

children is likely for this chemical that has been 

identified as a food additive by USFDA. 

NO 

Indoor Air Articles 

[Articles published by Brown et al. (1994), Daisey et 

al. (1994), Immerman and Schaum (1990), Samfield 

(1992), Shah et al. (1988), Sheldon et al. (1992), and 

Shields et al. (1996)]. 

Potential exposure to the general population and 

children from this chemical in indoor air is likely. NO 

List of Drinking Water Contaminants and their 

Maximum Contaminant Levels (MCLs); Accessed: 

05/20/08. 

http://www.epa.gov/safewater/contaminants/index.ht

ml#mcls see also 

http://www.access.gpo.gov/nara/cfr/waisidx_02/40cfr

141_02.html

Potential exposure to this Safe Drinking Water 

Act chemical for the general population and 

children is likely. 

NO 

National Air Quality System (AQS), U.S. EPA Office 

of Air and Radiation; Accessed: 05/15/08. 

http://www.epa.gov/aqspubl1/select.html

Potential exposure to the general population, 

environment, and children is likely for this 

National Air Monitoring System criteria air 

pollutant. 

NO 
4 

Table 1-7. Summary of Public Database Search Findings (CASRN 629-14-1) 

Data Source Descriptive Statement 

(Standard Drop-in Language) 

Yes/ No 

National Contaminant Occurrence Database (NCOD), 

U.S. EPA; Accessed: 05/19/08. 

http://www.epa.gov/safewater/data/ncod/index.html

Potential exposure to the general population, 

environment, and children is likely for this 

contaminant found in drinking water. NO 

National Emission Inventory (NEI) Database, U.S. 

EPA; Accessed: 05/14/08. 

http://www.epa.gov/ttn/chief/net/

Potential exposure to the general population, 

environment, and children is likely from this 

chemical found in the air as a point, non-point or 

mobile source. 

NO 

National Fish Tissue Study, U.S. EPA Office of 

Science and Technology; Accessed: 05/19/08. 

http://www.epa.gov/waterscience/fishstudy/overview.

htm

Potential exposure for the general population and 

children is likely to this chemical in fish tissue 

from lakes and reservoirs of the continental US. 

NO 

National Health and Nutrition Examination Survey 

(NHANES), Center for Disease Control; Accessed: 

02/12/08. 

http://www.cdc.gov/nchs/nhanes.htm

Potential exposure to the general population, 

environment, and children is likely for this 

chemical included in a study that evaluates how 

environmental exposures function as risk factors 

for disease. 

NO 

National Human Adipose Tissue Survey (NHATS), 

U.S. EPA Office of Pollution Prevention and Toxics; 

Accessed: 05/19/08. 

http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=

55204

Potential exposure to the general population and 

children is likely from this chemical that was 

found in a study of human adipose tissue. 

NO 

National Human Exposure Assessment Survey 

(NHEXAS), U.S. EPA National Exposure Research 

Laboratory; Accessed: 02/12/08. 

http://www.epa.gov/heasd/edrb/nhexas.htm

Potential exposure to the general population, 

environment, and children is likely from this 

chemical that was included in a community/ 

regional scale study to determine the association 

between exposure and daily activities. 

NO 

National Occupational Exposure Survey (NOES); 

Accessed: 05/14/2008. 

http://www.cdc.gov/noes/

Edit paragraph in Appendix B worker section 

according to findings. If Yes, include # of 

workers in next cell: 

NO 

National Sediment Inventory (NSI) Tissue Data, U.S. 

EPA Office of Water; Accessed: 05/16/08. 

http://www.epa.gov/waterscience/cs/nsidbase.html

Potential exposure to the general population and 

the environment is likely from this chemical 

found in sediments. 

NO 

National Status and Trends Program (NSTP) National 

Oceanic and Atmospheric Administration; Accessed: 

05/19/08. 

http://nsandt.noaa.gov/nsandt_overview.htm

Potential exposure to the general population and 

the environment is likely from this chemical 

found in aquatic life in estuarine and coastal 

waters of the US. 

NO 

National Stream Quality Accounting Network 

(NASQAN) Surface Water and Sediment Data, 

U.S.G.S.; Accessed: 05/16/08. 

http://water.usgs.gov/nasqan/progdocs/wri014255/res

ults/data.htm

Potential exposure to the general population, 

environment, and children is likely from this 

chemical found in one of the nation’s four largest 

river systems: the Mississippi, the Columbia, the 

Colorado or the Rio Grande. 

NO 

National Water Quality Assessment (NAWQA) 

Program; Accessed: 02/12/08. 

http://infotrek.er.usgs.gov/servlet/page?_pageid=543

&_dad=portal30&_schema=PORTAL30

Potential exposure to the general population, 

environment, and children is likely from this 

chemical found in ground water. 

NO 
5 

Table 1-7. Summary of Public Database Search Findings (CASRN 629-14-1) 

Data Source Descriptive Statement 

(Standard Drop-in Language) 

Yes/ No 

Permit Compliance System (PCS), U.S. EPA; 

Accessed: 02/12/08. 

http://www.epa.gov/enviro/

Potential exposure to the general population, 

environment, and children is likely from this 

chemical monitored at discharge points through 

NPDES permits. 

NO 

Section 21 Petition regarding chemicals in air 

fresheners 

Potential exposure to consumers and children is 

likely from this chemical that is contained in air 

fresheners. 

NO 

Source Ranking Database (SRD); Accessed: 

05/19/08. 

http://www.epa.gov/opptintr/exposure/pubs/srd.htm

This chemical was listed in the Source Ranking 

Database (SRD), which indicates that this 

chemical was contained in one or more consumer 

products. There is potential that consumers and 

children might be exposed to this chemical from 

consumer products containing this chemical. 

YES 

STORET, U.S. EPA Office of Water; Accessed: 

02/12/08. 

http://www.epa.gov/storet/

Potential exposure to the general population, 

environment, and children is likely from this 

chemical found in ground water or surface water. 

YES 

Total Exposure Assessment Methodology (TEAM), 

U.S. EPA; Accessed: 02/12/08. 

Potential exposure to the general population, 

environment, and children is likely from this 

chemical measured in humans. 

NO 

Voluntary Children’s Chemical Evaluation Program 

(VCCEP), U.S. EPA; Accessed: 10/17/08 

http://www.epa.gov/oppt/vccep/pubs/vcceprsp.pdf

Potential exposure to the general population, 

environment, and children is likely from this 

chemical covered under a voluntary USEPA pilot 

program investigating chemicals with a high 

likelihood of exposure to children. 

NO 

Sources with Additional Information 

Hazardous Substances Data Bank (HSDB) 

http://toxnet.nlm.nih.gov/ Summarize in appropriate section after this table YES 

High Production Volume (HPV) Challenge 

Submission contains Use and Exposure Information 

http://cfpub.epa.gov/hpv%2Ds/

Summarize in appropriate section after this table NO 

Extended High Production Volume Program (EHPV), 

U.S. EPA; Accessed: 12/03/08. 

http://www.regulations.gov/fdmspublic/component/m

ain?main=DocketDetail&d=EPA-HQ-OPPT-2006-

1020 

Summarize in appropriate section after this table NO 

National Institute of Health’s (NIH) Household 

Products Database 

http://hpd.nlm.nih.gov/products.htm

This chemical was listed in the NIH Household 

Products Database, which indicates that this 

chemical was contained in one or more household 

products. There is potential that consumers and 

children might be exposed to this chemical from 

consumer products containing this chemical. 

NO 

Preliminary Assessment Information Rule (PAIR); 

TSCA Section 8(a) PAIR information is confidential. NO 
6 

Table 1-7. Summary of Public Database Search Findings (CASRN 629-14-1) 

Data Source Descriptive Statement 

(Standard Drop-in Language) 

Yes/ No 

Screening Information Data Set (SIDS) documents 

contains Use and Exposure Information 

http://www.chem.unep.ch/irptc/sids/oecdsids/sidspub.

html

Summarize in appropriate section after this table NO

Toxic Release Inventory (TRI), U.S. EPA 

http://www.epa.gov/tri/ Summarize in appropriate section after this table NO 

OSHA PEL: 

http://www.osha.gov/SLTC/pel/recognition.html 

Note: edit statement in Appendix B worker 

section and if Yes, include PEL in next cell: NO 

ACGIH TLVs and BEIs. 2009. Note: edit statement in Appendix B worker 

section and if Yes, include TLV in next cell: NO 

NIOSH Pocket Guide to Chemical Hazards. 

http://www.cdc.gov/NIOSH/npg/npgdcas.html

Note: edit statement in Appendix B worker 

section and if Yes, include REL in next cell: NO 

HPV Submission Use and Exposure Information Summary 

No HPV submission was found. 

EHPV Submission Use and Exposure Information Summary 

No EHPV submission was found. 

HSDB Use and Exposure Information Summary 

Skin, Eye and Respiratory Irritations: 

Ethylene glycol diethyl ether vapor is irritating to the eyes and mucous membranes. 

[Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley 

& Sons. New York, N.Y. (2001)., p. V7 176] **PEER REVIEWED** 

Protective Equipment & Clothing: 

Protective goggles or face shield; rubber gloves. 

[U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Manual 

Two. Washington, DC: U.S. Government Printing Office, Oct., 1978.] **PEER REVIEWED** 

Glove manufacturers have recommended gloves of neoprene or nitrile butyl rubber construction 

for protection against liquid ethylene glycol diethyl ether. 

[Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens, 2002. 4th ed.Vol 1 

A-H Norwich, NY: Noyes Publications, 2002., p. 1091] **PEER REVIEWED** 

Where the potential exists for exposure to ethylene glycol diethyl ether, use a ...NIOSH approved 
7 

supplied-air respirator with a full facepiece operated in the positive pressure mode or with a full 

facepiece, hood, or helmet in the continuous flow mode, or use a NIOSH approved selfcontained breathing apparatus with a full facepiece operated in pressure-demand or other positive 

pressure mode. 

[Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens, 2002. 4th ed.Vol 1 

A-H Norwich, NY: Noyes Publications, 2002., p. 1091] **PEER REVIEWED** 

Personnel protection: ... Wear appropriate chemical protective gloves, boots and goggles. Wear 

positive pressure self-contained breathing apparatus when fighting fires involving this material. 

[Association of American Railroads; Bureau of Explosives. Emergency Handling of Hazardous 

Materials in Surface Transportation. Association of American Railroads, Pueblo, CO. 2005, p. 

403] **PEER REVIEWED** 

Major Uses:

INERT REACTION MEDIUM 

**PEER REVIEWED** 

SOLVENT FOR ESTER GUM, SHELLAC AND SOME RESINS AND OILS 

[Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 

1965., p. 612] **PEER REVIEWED** 

Organic synthesis (reaction medium), solvent and diluent for detergents 

[Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 14th Edition. John Wiley & Sons, 

Inc. New York, NY 2001., p. 465] **PEER REVIEWED** 

Dye solvents in non-grain raising stains 

[Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: 

John Wiley and Sons, 1978-1984., p. V21 484] **PEER REVIEWED** 

SIDS Document Use and Exposure Information Summary 

No SIDS documents were found for this chemical. 

TRI Release Data Summary 

This chemical is reported under the category “certain glycol ethers” in TRI under the CAS 

number N230. Refer to Table 2-2. 

MSDS Summary Information 

A material safety data sheet (MSDS), from Alfa Aesar,12 provides some information about the 

safety of the chemical including hazards, accidental release measures, handling and storage, 

exposure controls/personal protective equipment, toxicological information, disposal and 

transport information. This MSDS was provided to EPA in a separate PDF file: MSDS 629-14-

1.pdf. This MSDS was downloaded from the Internet and serves as an example MSDS only. 

 

12 Alfa Aesar, 2008. Material Safety Data Sheet for 1,2 - diethoxyethane and CASRN# 629-14-1. Accessed, 

8/26/2009. http://www.alfa.com/content/msds/USA/L14283.pdf 
8 

EPA has not reviewed the MSDS information nor does it endorse the company, the product, or 

the use of the MSDS information. 

General Equipment: Impervious gloves, safety glasses/tightly sealed goggles. 

Respirator: Use a suitable respirator when high concentrations are present. 

Health Effects: Irritant to skin and respiratory system; strong irritant with danger of severe eye 

injury; possible risk of harm to the unborn child.