# Support Documents for

Significant New Use Rules (SNURs) on

Premanufacture Notices (PMNs)

P-09-154, P-09-155, and P-09-156

EPA Docket EPA-HQ-OPPT-2010-1075

# Index

A-001 Structure Activity Team (SAT) Report s for

PMNs P -09- 154, P -09- 155, and P -09-156

A-002 Initial Review Engineering Reports for

PMNs P -09- 154, P -09- 155, and P -09-156

A-003 Initial Review Exposure Reports for

PMNs P -09- 154, P -09- 155, and P -09-156

# A-001

Structure Activity Team (SAT) Reports

for PMNs P-09-154, P-09-155, and P-09-156

## SAT Report

PMN Number: P-09-0154

SAT Date: 1/23/2009

Related cases :

Health related cases:

Ecotox related cases:

Concern levels :



### Type of Concern: Health Eco Comments

Level of Concern: 2 3

Persistence Bioaccum Toxicity Comments

1 1 2 PMN

1 1 1 Hyd Pdt

Exposure Based Review :

Health: Yes Exposure based testing (health): Inhalation only

Ecotox: Yes

Routes of exposure : Health: Dermal, inhalation

Ecotox: All releases to water

Fate: ;

P 2 Rec Comments :

Comment: SAT had no comment

Keywords :

Keywords: LUNG; IRR-L,S,MM,E; SENS-S,L; MUTA, ONCO, DEVEL, MALE

REPRO, LIVER, KIDNEY; AQUATOX

Summary of Assessment :

Fate :

Fate Summary: P-09-0154

FATE: Estimations for hydrolysis product

log Kow = 2.43 (E)

log Koc = 4.59 (E)

log Fish BCF = 1.17 (E)

PMN Substance: Liquid with MP < 25 EC (E)

S = Reacts

Hydrolysis Half-life = hr

### VP = 1.9E-4 torr at 25 EC (E)

BP = 344 EC (E)

H < 1.00E-8 (E)

POTW removal (%) = 90-99 via hydrolysis then sorption and biodeg

Time for complete ultimate aerobic biodeg = wk-mo

Sorption to soils/sediments = strong

PBT Potential: PMN P1B1; Hyd Pdt P1B1

*CEB FATE: Migration to ground water = slow

Health :

Health Summary: Expect moderate absorption with reaction via all routes

( p che m ); expect oxidation of the terminal double bonds via an intermediate. Concern

for lung toxicity and irritation to all tissues from the reactive moieties. Also

concern for skin and lung sensitization, mutagenicity, oncogenicity, developmental toxicity,

male reproductive, liver, and kidney toxicity based on the oxidation product.

Ecotox :

Test

Organism Test

Type Test End

Point Predicted Measured Comments

fish 96-h LC50 0.016

daphnid 48-h LC50 4.4

green algal 96-h EC50 0.74

fish

_ chronic value 0.004

daphnid chronic value 0.009

algal

_ chronic value 0.91

Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value

_

Ecotox Values Comments: Predictions are based on SARs for ; SAR chemical

class = ; MW 327; log Kow = 5.60 (EPI); p H7; effective concentrations based on

100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3;

and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern

( p pb) 1

SARs

SAR Class

Ecotox Factors Comments:

SAT Chair: L Keifer 564-8916

## SAT Report

PMN Number: P-09-0155

SAT Date: 1/23/2009

Related cases :

Health related cases:

Ecotox related cases:

Concern levels :



### Type of Concern: Health Eco Comments

Level of Concern: 2 3

Persistence Bioaccum Toxicity Comments

1 1 2 PMN

1 1 1 Hyd Pdt

Exposure Based Review :

Health: Yes Exposure based testing (health): Inhalation only

Ecotox: Yes

Routes of exposure : Health: Dermal, inhalation

Ecotox: All releases to water

Fate: ;

P 2 Rec Comments :

Comment: SAT had no comment

Keywords :

Keywords: LUNG; IRR-E,S,MM,L; THYROID; SENS-S; DEVEL NEURO;

AQUATOX

Summary of Assessment :

Fate :

Fate Summary: P-09-0155

FATE: Estimations for hydrolysis product

log Kow = 2.59 (E)

log Koc = 5.12 (E)

log Fish BCF = 1.30 (E)

PMN Substance: Liquid with MP < 25 EC (E)

S = Reacts

Hydrolysis Half-life = hr

### VP = 2.0E-6 torr at 25 EC (E)

BP > 400 EC (E)

H < 1.00E-8 (E)

POTW removal (%) = 90-99 via hydrolysis then sorption and biodeg

Time for complete ultimate aerobic biodeg = wk-mo

Sorption to soils/sediments = strong

PBT Potential: PMN P1B1; Hyd Pdt P1B1

*CEB FATE: Migration to ground water = slow

Health :

Health Summary: Expect moderate absorption with reaction via all routes

( p che m ); formation is possible in the body. Concern for lung toxicity and irritation to

all tissues from the reactive moieties. Also concern for thyroid toxicity and dermal

sensitization from the formed; and developmental neurotoxicity based on thyroid

toxicity to the dams.

Ecotox :

Test

Organism Test

Type Test End

Point Predicted Measured Comments

fish 96-h LC50 0.046

daphnid 48-h LC50 0.064

green algal 96-h EC50 0.052

fish

_ chronic value 0.004

daphnid chronic value 0.006

algal

_ chronic value 0.063

Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value

_

Ecotox Values Comments: Predictions are based on SARs for ; SAR

chemical class = ; MW 395; log Kow = 5.76 (EPI); p H7; effective

concentrations based on 100% active ingredients and mean measured concentrations; hardness

<150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern

( p pb) 1

SARs

SAR Class

Ecotox Factors Comments:

SAT Chair: L Keifer 564-8916

## SAT Report

PMN Number: P-09-0156

SAT Date: 1/23/2009

Related cases :

Health related cases:

Ecotox related cases:

Concern levels :



### Type of Concern: Health Eco Comments

Level of Concern: 2 3

Persistence Bioaccum Toxicity Comments

1 1 2 PMN

2 1 1 Hyd Pdt

Exposure Based Review :

Health: Yes Exposure based testing (health): Inhalation only

Ecotox: Yes

Routes of exposure : Health: Dermal, inhalation

Ecotox: All releases to water

Fate: ;

P 2 Rec Comments :

Comment: SAT had no comment

Keywords :

Keywords: LUNG; IRR-E,S,MM,L; THYROID; SENS-S; DEVEL NEURO;

AQUATOX

Summary of Assessment :

Fate :

Fate Summary: P-09-0156

FATE: Estimations for low weight hydrolysis product

log Kow = -2.96 (E)

log Koc = 4.72 (E)

log Fish BCF = 0.50 (E)

PMN Substance: Liquid with MP < 25 EC (E)

S = Reacts

Hydrolysis Half-life $ mo

### VP < 1.0E-6 torr at 25 EC (E)

BP > 400 EC (E)

H < 1.00E-8 (E)

POTW removal (%) = 75-90 via hydrolysis then sorption and biodeg

Time for complete ultimate aerobic biodeg $ mo

Sorption to soils/sediments = strong

PBT Potential: PMN P1B1; Hyd Pdt P2B1

*CEB FATE: Migration to ground water = slow

Health :

Health Summary: Expect moderate absorption with reaction via all routes

( p che m ); formation is possible in the body. Concern for lung toxicity and irritation to

all tissues from the reactive moieties. Also concern for thyroid toxicity and dermal

sensitization from the formed; and developmental neurotoxicity based on thyroid

toxicity to the dams.

Ecotox :

Test

Organism Test

Type Test End

Point Predicted Measured Comments

fish 96-h LC50 1.7

daphnid 48-h LC50 13

green algal 96-h EC50 1.5

fish

_ chronic value 0.064

daphnid chronic value 0.091

algal

_ chronic value 2.7

Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value

_

Ecotox Values Comments: Predictions are based on SARs for ; SAR chemical

class = ; MW 507; log Kow = 3.78 (EPI); p H7; effective concentrations based on

100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3;

and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern

( p pb) 6

SARs

SAR Class

Ecotox Factors Comments:

SAT Chair: L Keifer 564-8916

# A-002

Initial Review Engineering Reports

for PMNs P-09-154, P-09-155, and P-09-156

### INITIAL REVIEW ENGINEERING REPORT

P-09-0154

Focus Ready Draft 1/29/2009

ENGINEER: Jon \ CPW

PV (kg/yr):

Revision Notes/Assessment Overview:

SUBMITTER:

USE:

OTHER USES:

MSDS: LABEL :

Gen Eqpt:

Respirator :

Health Effects:

TLV/PEL :

CRSS:

Chemical Name:

S-H2O g/L @

VP: orr @

MW: 0.0%<500 0.0%<1000

Physical State and Misc CRSS Info:

Neat: Mfg:

Proc/Form: End Use:

Consumer Use :

SAT (concerns):

Related Cases and Misc SAT Info :

. Migration to groundwater : Slow

PBT rating:

Health:

Eco:

OCCUPATIONAL EXPOSURE RATING:NOTES & KEY ASSUMPTIONS:

Generated by the 06/07/2005 version of ChemSTEER.

POLLUTION PREVENTION CONSIDERATIONS:

P2 Claim:

P2 REC:

1)P-09-0154P-09-0154

### INITIAL REVIEW ENGINEERING REPORT

P-09-0155

Focus Ready Draft 1/29/2009

ENGINEER: Jon \ CPW

PV (kg/yr):

Revision Notes/Assessment Overview:

SUBMITTER:

USE:

OTHER USES:

MSDS : LABEL :

Gen Eqpt:

Respirator:

Health Effects:

TLV/PEL :

CRSS:

Chemical Name:

S-H2O: g/L @

VP: torr @

MW: %<500 %<1000

Physical State and Misc CRSS Info:

Consumer Use:

SAT (concerns):

Related Cases and Misc SAT Info:

.

OCCUPATIONAL EXPOSURE RATING:

NOTES & KEY ASSUMPTIONS:Generated by the 06/07/2005 version of ChemSTEER.

POLLUTION PREVENTION CONSIDERATIONS:

P2 Claim:

P2 REC:

EXPOSURE-BASED REVIEW:P-09-0155

.P-09-0155

### INITIAL REVIEW ENGINEERING REPORT

P-09-0156

Focus Ready Draft 1/29/2009

ENGINEER: Jon \ CPW

PV (kg/yr):

Revision Notes/Assessment Overview:

SUBMITTER:

USE:

OTHER USES:

MSDS: LABEL :

Gen Eqpt:

Respirator :

Health Effects:

TLV/PEL

CRSS:

Chemical Name:

S-H2O: g/L @

VP: torr @

MW: %<500 %<1000

Physical State and Misc CRSS Info:

Consumer Use:

SAT (concerns):

Related Cases and Misc SAT Info :

.OCCUPATIONAL EXPOSURE RATING:

NOTES & KEY ASSUMPTIONS:

Generated by the 06/07/2005 version of ChemSTEER.

POLLUTION PREVENTION CONSIDERATIONS:

P2 Claims:

P2 REC:

EXPOSURE-BASED REVIEW:P-09-0156

.P-09-0156

.

# A-003

Initial Review Exposure Reports

for PMNs P-09-154, P-09-155, and P-09-1561/28/2009 Page of1/28/2009 Page of1/28/2009 Page of1/28/2009 Page of1/28/2009 Page of1/28/2009 Page of1/28/2009 Page of1/28/2009 Page of1/28/2009 Page of1/28/2009 Page of1/28/2009 Page of1/28/2009 Page of1/28/2009 Page of1/28/2009 Page of1/28/2009 Page of

INITIAL REVIEW EX POSURE REPORT

Chemical ID: P090154

SCENARIO #: Number of Site s: RELEASE ACTIVITY:Use: max

LADD

SIC-CODE DESCRIPTION:

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