Boscalid Dietary Exposure and Risk Assessment DP Number: 410743 PC Code: 128008

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, D.C. 20460



### MEMORANDUM

June 24, 2013 O FF IC E O F CH E MICAL SAFETY AN D POL L UTION PREVENTION



### SUBJECT: REVISED: Boscalid. Chronic Aggregate D i etary (Food and Drinking Water) Exposure and Risk Assessment for the Section 3 Reg i stration For Globe Artichoke, Belgium Endive, and Persimmon and for Crop Group/Subgroup Conversions

PC Code: 128008 DP Barcode: 410743 Decision No

. : 468292 Registration No. : .: 7969

- 187; 7969-199; 7969- 186;; 7969- 289 Petition No.: 2E8068 Regulatory Action: Section 3 Registration Risk Assessment Type: Single Chemical/Aggregate Case No.: NA TXR No.: NA CAS No

. : 188425-85-6
MRID No.: 48897401,48897402,48897403 40

### FR: 180.589

### ~~
REVIEWER: Stephen Funk, Sen i or Chemist Risk Assessment Branch III (RAB III) Health Effects D i vision (HED) (7509P)

Christine Olinger, Branch Chief

# ~ THROUGH

TO: Risk Assessment Branch III (RAB III) Health Effects Division (HED) (7509P)

.....
Barry O'Keefe, Risk Assessor RAB lll / HED (7509P)

And

Barbara Madden Andrew Ertman Registration Division (RD; 7505P)



### The document of April 30, 2013 is revised to include consideration of increased residue l eve l s on several crop groups/subgroups that result from harmonization of tolerances with Codex MRLs

. These harmonizations are part of the crop group/subgroup conversions

. The changes are as follows: bulb vegetable group 3

- 07**(3.0~5.0** 

### ppm); fruiting vegetables group 8-10**(1.2~3.0** 

### ppm); citrus fruit group 8

- 10**(1.6~2.0** 

### ppm); caneberry subgroup 13

- 07A**(6.0~10.0** 

### ppm); small vine fruit subgroup 13-07F**(3.5~5.0** 

### ppm);
root vegetab l e subgroup lB**(1 0~2.0**  

### ppm). The update from canola, sunflower, and
cotton seeds to oilseed group 20 includes a revision in the tolerance from 3.5 ppm to 5.0

Page I of24Boscalid Die tary Exposure and Risk Assessment DP Number: 410743 PC Code: 128008



### ppm in order to harmonize with Canada. Also, the proposed turnip greens tolerance ( 18 ppm) is based on the proposed addition of tu rnip greens (turnip tops) to crop subgroup 

### SB

, for which adequate data were previously presented for t he repre se ntati ve commodity mustard greens. The tolerance proposal of 18.0 ppm is changed to 40.0 ppm in order to harmonize w i th Codex. These are the only changes from the April 30, 2013 Memo.

Executive Summary



### Acute and chronic dietary (food and drink in g water) exposure and risk assessments were conducted using the D i etary Exposure Evaluation Model (DEEM

- FC ID

, Vers i on 3.16), which use s 2003

- 2008 food consumption data from the U.S

. Department of Agr i culture's National Health and N utrit ion Examination Survey, What We Eat in America, (NHANES/WWE I A). This memorandum was reviewe d by two peer reviewers of the DESAC per the current DESAC policy.

The ana l yses were performed as part of the registration action fo r bosca li d on persimmon, Belgium endive, globe ar t ichoke, and crop group/subgroup conversions. Th e g r ound
water segment of the analysis also included new proposed us es on tomato transplants in greenhouses for consumers and lathe house use and homeowner uses on fru it trees , nut trees, and ornamenta l s.

The las t d i etary risk assessment for boscalid was performed in 2009 for th e citrus crop group 10, for a l falfa, and for an increase in tolerance for the stone fruit group 12 (DP#365262

, A. 

### Ac ierto

, 1 11 19 / 2009). That assessment has been updated by new estimated percent crop treated data from t he Biolo gica l and Econmics A nalysis Divi sio n (BEAD), by ne w drinking water concentration level estimates from the Environmental Fate and E ffects Division (EFED), and by th e addition of new commodities (globe artichoke, Belgium e nd ive, persimmon).

Acute D i etary (Food and Drinking Water) Exposure Results and Characterization

S i nce no observed effects could be attributed to a single dose, an acute endpoint was not established

. Therefor e, an acute dietary exposure assessment was not conducted.

Chronic Dietary (Food and Drinking Water) Exp o sure Results and Characterization

The chronic dietary analysis was performed using to l erance l evel res idues and 100% crop treated assumptions. Dietary risk estimates were determined considering exposures from food plus drinking water. Boscalid exposure from the existing uses, including tole r ance modifications to harmonize with Codex, and the proposed new uses on persimmon, Belgium endive, and globe artichoke result s in estimated risks that are below the Agency's l eve l of concern for food plus drinking water. The highest exposure and risk estimates for food plus drinking water are 20% of the chronic pop ulat ion adjusted dose ( cPAD) for the U

. S

. population and 56% for c hil dren 1-2 years old, the most highly exposed population subgroup.

Page 2 of24Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

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### Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

A cancer di e tary assessment was not conducted since boscalid was classified by the Cancer Assessment Review Committee (CARC) as “ suggestive evidence of carcinogenicity” and quantification of human cancer risk is not recommended.

I. Introdu c tion

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum accepta ble dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the reference dose point of departure (POD, NOAEL, LOAEL) di vided by the required uncertainty and safety factors.

For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in more detail are avai lable on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User ’s Guide,” 6/21/2000, web link:

http://www.epa.gov/fedrgstr/EPA

- PES T/2000/July/Day

- 12/6061.pdf ; or see SOP 99.6 (8/20/99).

The most recent dietary risk assessment for boscalid was conducted to support use on the citrus fruit group and alfalfa and an inc r ease in the stone fruit group toler a nce (DP# 3 65262, A. Acierto, 1 1/19/2009 ).

II. Residue Information

The Interregional Research Project No. 4 ( IR

- 4 ) has proposed new uses on globe artichoke, Belgium endive, and persimmon

. A mendment of Section 3 registration of Pristine® (EPA Reg. No. 7969199 is requested

. Prist ine® is a mixture of pyraclostrobin and boscalid. This assessment addresse s on ly boscalid.

IR

- 4 also requested crop group conversions for bulb vegetable group 3

- 07, fruiting vegetable group 8

- 10, citrus fruit group 10

- 10, pome fruit group 11

- 10, berry su bgroups 13

- 07A, b, F, and G, and oilseed group 20. These conversions sometimes resulted in increased tolerances from harmonization with Codex.

The nature of boscalid residues in primary crops and livestock is considered adequately understood, based on the acceptable metabolism studies on lettuce, grapes, beans, goats and hens. For purposes of tolerances and dietary risk assessment, the HED, through its Metabolism Assessment Review Committee (MARC), has concluded that the residue of concern in plant commodities is boscalid, and the residue s of concern in livestockBoscalid Dietary Exposure and Risk Assessment DP Number: 410743

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### commodities include boscalid, its 5

- hydroxy metabolite ( M510F01 )

, and the glucuronic acid conjugate of the 5

- hydroxy metabolite (M510F02).

Permanent tolerances have been e stablished under 40 CFR §180.589(a)(1) for the fungicide boscalid in plant commodities, ranging from 0.05 ppm in/on coffee, peanuts , and tuberous and corm vegetables (subgroup 1C) to 60 ppm in/on leafy greens except head and leaf lettuce (subgroup 4A). Se parate tolerances have also been established for indirect or inadvertent residues of boscalid in rotational crops under 40 CFR §180.589(d) at levels ranging from 0.05 to 8.0 ppm. Tolerances for livestock commodities have been established under 40 CFR §180 .589 (a)(2) for the combined residues of boscalid and its metabolites 2

- chloro

- N

- (4′

- chloro

- 5

- hydroxy

- biphenyl

- 2

- yl)nicotinamide and the glucuronic acid conjugate of the 5

- hydroxy metabolite at levels ranging from 0.02 ppm in eggs to 0.35 ppm in the meat byproducts of cattle, goats, horses, and sheep.

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, and 2010. Over t his 3

- year period, PDP analyzed 1479 samples of catfish for boscalid residues. None of the samp les contained detectable residues (lod about 0.006 ppm) . As a result, residues in fish were not included in the assessment.

The potential for secondary transfer of boscalid residues of concern in meat, milk, poultry, and eggs exists because there are s everal livestock feedstuffs that are associated with the existing uses. The proposed uses do not add to the potential for transfer, as the new commodities do not include livestock feed items of regulatory interest. A summary of the proposed and recomme nded tolerances for the new uses are listed in Table 1.

Table 1. Tolerance Summary for Boscalid for New Uses Commodity Proposed Tolerance (ppm) Recommended Tolerance (ppm) Artichoke, globe 6.0 6.0 Endive, Belgium 5.0 6.0 Persimmon 7.0 8.0

Residue Data for Chronic Assessment:

The assessment is slightly refined. The chronic dietary exposure and risk assessment is based on tolerance

- level residues for all commodities

. The data used in the 200 9 dietary assessments were also used in this current anal ysis except for the addition of tolerances fo r globe artichoke, Belgium endive, and persimmon

. BEAD has provided percent crop treated information for boscalid ( J.Alsadek, BEAD, 03/08/2013)

. As a refinement, t he weighted average %CT was incorporated , which i s listed as Adjustment Factor 2 in the DEEM

- FCID R 0 8 file (see Appendix 1)

. One hundred percent crop treated was assumed for commodities with no % CT data

.Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

PC Code: 128008

Page 5 of 24 

### Crop group conversions included a consideration of harmonization of tolerances with Codex MRLs. This resulted in increased tolerances, as follows: bulb vegetable group 3

- 07 (3.0→5.0 ppm); fruiting vegetables group 8

- 10 (1.2→3.0 ppm); citrus fruit group 8

- 10 (1.6→2.0 ppm); caneberry subgroup 13

- 07A (6.0→10.0 ppm); small vine fruit subgroup 13

- 07F (3.5→5.0 ppm); root vegetable subgroup 1B (1.0→2.0 ppm) . The update from canola, sunflower, and cotton seeds to oilseed group 20 includes a revision in the tolerance from 3.5 ppm to 5.0 ppm in order to harmonize with Canada. Also, the proposed turnip greens tolerance (18 ppm) is based on the proposed additi on of turnip greens (turnip tops) to crop subgroup 5B, for which adequate data were previously presented for the representative commodity mustard greens. The tolerance proposal of 18.0 ppm is changed to 40.0 ppm in order to harmonize with Codex. These inc reases in tolerances resulted in apparent increases in dietary exposure, because tolerance level values were used for the plant commodity entries

. 

### The following average percent crop treated estimates were used in the chronic dietary risk assessments for t he crops that are currently registered for boscalid: almonds 40%; apples 15%; apricots 25%; green beans 5%; blueberries 35%; broccoli <2.5%; cabbage 5%; caneberries 45%; canta loupes 5%; carrots 15%; cauliflower 5%; celery <2.5%; cherries 45% ; cucumbers 5% ; dry beans/dry peas <2.5%; garlic 5%; grapes 30%; hazelnuts 5%; lettuce 25%; nectarines 15%; onions 20%; peaches 20%; peanuts <1%; pears 15%; green peas <1%; peppers <2.5%; pistachios 30%; plums/prunes 5%; potatoes 20%; pumpkins 10%; squash 5%; strawberr ies 55%; tomatoes 5%; walnuts <1%; watermelons 25%.

A value of 0.5 ppm was used for honey, based on the existing tolerance in the European Union.

The analysis includes HED

- recommended tolerance level residue values for the herb subgroup 19A, although the se tolerances were never finalized. The tolerances were recommended in connection with PP# 6E7164 and PP#7F7169 (DP 336632, C. Olinger, 11/27/2007).

No new experimental processing data were incorporated into this analysis

. The processing factors from earl ier dietary assessment s were derived as follows

. For processed commodities where data were available to show no concentration (apple juice, dried plum prunes , rice bran, wheat flour, sunflower oil, mint oil, tomato puree, tomato juice, soybean oil

, and cot tonseed oil), the processing factor was set to 1. For processed commodities where the raw agricultural commodity ( RAC ) tolerance is adequate to cover the very slight concentration seen in the processing study (wheat germ, wheat bran, and tomato paste), th e residue was set at the RAC level and the processing factor was reduced to 1. For processed commodities with established tolerances (raisin, peanut oil

, and citrus oil ), the processed commodity tolerance was used and the processing factor was set to 1.0

. For all other processed commodities for which data were not available, DEEM (version 7.81) processing factors were used ( DP# 336633, D. Davis, 12/17/2007).Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

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### The complete residue values (food and drinking water) and processing factors are shown in the Chr onic Residue Input File, Attachment 1

.

III. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by EFED ( D 409880 , K. White, 04/30 /2013 revision of 04/17/2013 an of 03/21/2013 and of 11/27/2012 document ) and inc orporated directly into this dietary assessment. Water residues were incorporated in the DEEM

- FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.”

The drinking water assessment considered new uses on Belgium endi ve, globe artichoke, and persimmon and new uses on tomatoes in greenhouses and lath houses, and homeowner garden spray and ornamental applications. All existing uses were also considered.

Surface water estimated drinking water concentrations ( 

### EDWC ) were determined in previous assessments. See Tier I Drinking Water Exposure Assessment for the Section 3 New Use of Boscalid on Various Agricultural Crops Including Cranberries ( White, 2012, D405064 ) for a discussion of modeling and estimatin g surface water concentrations. The EDWCs for boscalid in surface water were calculated using the screening model FIRST (FQPA Index Reservoir Screening Tool; v.1.1.1; dated 03/25/08)

. Screening Concentration in Ground Water (SCI

- GROW v2.3, Jul. 29, 2003) is a regression model used as a screening tool to estimate pesticide concentrations found in groundwater used as drinking water. Tier 1 groundwater EDWCs for boscalid were derived with PRZM

GW (Pesticide Root Zone Model for Groundwater, version 1.0, Aug ust 31, 2012 ), using the GW

- GUI (Graphical User Interface, version 1.0, August 31, 2012 ). PRZM

- GW is a

one

- dimensional, finite

- difference model that estimates the concentrations of pesticides in groundwater. It accounts for pesticide fate in the crop root zone by simulating pesticide transport and degradation through the soil profile after a pesticide is applied to an agricultural field. PRZM

- GW permits the assessment of multiple years of pesticide application (up to 100 years) on a single site. Six standar d scenarios, each representing a different region known to be vulnerable to groundwater contaminations, are available for use with PRZM

- GW for risk assessment purposes.

The maximum Tier 1 estimated chronic groundwater EDWC is 697 ppb. The maximum Tier 1 estimated chronic surface water EDWC is 26.4 ppb. This is based on turf use. The cranberry use (Table 2 ) has been withdrawn by IR

- 4. The ground water value is higher than the surface water value and was therefore used in the assessment. The EFED models a nd their descriptions are available at the EPA internet site : http://www.epa.gov/oppefed1/models/water/

. See Table 2

.

Table 2. Tier I EDWCs based on boscalid use on turf and cranberries. 1,2

Sou rce of Drinking Water Boscalid concentration in drinking water (μg/L)
Turf Cranberry 2

Acute Annual Average or Post

Breakthrough Average Acute Annual Average or Post Breakthrough AverageBoscalid Dietary Exposure and Risk Assessment DP Number: 410743

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### Table 2. Tier I EDWCs based on boscalid use on turf and cranberries. 1,2

Sou rce of Drinking Water Boscalid concentration in drinking water (μg/L)
Turf Cranberry 2
Surface water 97.3 26.4 426 426 Groundwater 7 73 

### 697 660 393

1 These are the highest EDWCs for the proposed and relevant previously ev aluated use scenarios.

2 Previously estimated acute and annual average surface water concentrations for turf were 97.3 and 26.4 μg/L, respectively. Previously estimated groundwater co ncentrations were 1.7 μg/L ( White, 2012, D405064 )

. The previously evaluated use on cranberry, which resulted in the highest EDWC for surface water, will be excluded from the final label.



### IV. DEEM

- FCID Program and Consumption Information

Boscalid chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM

FCID, Version 3.16, which incorporates consumption data from USDA’s NHANES/WWEIA

, conducted fro m 2003 to 2008. The data are based on the reported consumption of more than 20,000 individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA

- defined food commodities (e.g., apples, peeled fruit

- cooked; fr esh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and wit hin population subgroups. However, for acute exposure assessment, consumption data are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 y ears old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food

- form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food fo rm to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposur e. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

V. Toxicological Information

No new studies have been received and no changes have been made since the last dietar y risk assessment. The Health Effects Division (HED) Hazard Identification Assessment Review Committee (HIARC) evaluated the toxicology database for boscalid and established the chronic reference dose on January 23, 2003. The standard uncertainty factor of 100 to account for inter

- and intra

- species variability was applied to all risk assessments. The Food Quality Protection Act of 1996 ( FQPA ) safety factor for boscalidBoscalid Dietary Exposure and Risk Assessment DP Number: 410743

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Page 8 of 24 

### was reduced to 1 X since the toxicity database is complete, there is no concern for

ne urotoxicity, there is no evidence of increased pre

- or post

- natal susceptibility

, and exposure estimates are not expected to underestimate risk.

The toxicological endpoints selected by HED/HIARC for dietary exposure are summarized in Table 3

.

Table 3

. Summary of Dose and Toxicological Endpoints for Boscalid for Use in Dietary Exposure Assessment

. Exposure/ Scenario Point of

Departure Uncertainty/FQPA

Safety Factors RfD/PAD Study an d Toxicological Effects Acute Dietary (All Populations) No appropriat e endpoint attributable to a single dose was available in the current

database, including the developmental toxicity studies. Therefore, an acute RfD was not recommended for the general U.S. population or any population subgroup. Chronic Dietary (All Po pulations) NOAEL = 21.8

mg/kg/day UF A = 10x

UF H = 10x FQPA SF = 1x Chronic RfD = 0.218 mg / kg. /d ay

Chronic PAD = 0.218 mg/kg/day Chronic rat,

carcinogenicity rat and 1

- year dog studies LOAEL =

~ 58 mg,kg/day based on liver and t h yroid effects Can c er Cla ssified as “suggestive evidence of carcinogenicity.” Quantification of human

cancdr risk is not recommended. Point of Departure (P o D) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (i ntraspecies). UF H = potential variation in sensitivity among members of the human population (interspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose.



### VI. Results/Discussion

As st ated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM

- FCID analyses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 4 are for the
gen eral U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years.

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The chronic dietar y (food and drinking water) exposure analysis is a slightly refined
assessment . The only refinement is the use of percent crop treated (% CT) for some crops. Tolerance values were used for all raw agricultural commodities (RACs)

. Based on the assumptions described above in section s II and III, the chronic dietary exposure of the general U

. S

. population and all population subgroups are below the Agency’s level ofBoscalid Dietary Exposure and Risk Assessment DP Number: 410743

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Page 9 of 24 

### concern (i.e., <100% of the cPAD of 0.218 mg/kg). The chronic dietary (food and drinking wat er) exposure estimates are 20% of the cPAD for the general U.S. population and 56 % of the cPAD for c hildren 1

- 2 years old, the most highly exposed population subgroup. T he results of the dietary exposure and risk estimates a re summarized below (Table 4 ).

Table 4 . Summary of Dietary 

### (Food and Drinking Water) Exposure and Risk for Boscalid 1,2

Population Subgroup Acute Dietary Chronic Dietary Cancer

Dietary Exposure (mg/kg/day) % aPAD Dietary Exposure (mg/kg/day) % cPAD Dietary Exposure (mg/kg/day) Risk

General U.S. Population

N/A N/A 0.0 42751 20

N/A N/A All Infants (< 1 year old) 0.091079 42

Children 1

- 2 years old 0.121118 56

Children 3

- 5 years old 0.0882 99 41

Children 6

- 12 years old 0.047 7 44 22

Youth 13

- 19 years old 0.0297 96 14

Adults 20

- 49 years old 0.036670 17

Adults 50+ years old 0.038128 18

Females 13

- 49 years old 0.036893 17

1 The population subgroup with the highest estimated chronic dietary (food + drinking water) exposure and risk is indicated by b old text.
2 NA = not applicable



### VII. Characterization of Inputs/Outputs

The chronic dietary exposure analysis is slightly refined. For some crops percent crop (%CT) treated data were utilized. Dietary estimates could be further refined through the

use of average field trial data and survey data. However, since estimated exposures and risks using conservative assumptions are well below the Agency’s level of concern, such additional refinement is not necessary.

VIII. Conclusions

Chronic dietary expos ure analys i s using DEEM

- FCID indicate s that chronic dietary exposure to the residues of boscalid from food and drinking water are well below HED’s level of concern. The estimated chronic dietary exposure is 20% of the cPAD for theBoscalid Dietary Exposure and Risk Assessment DP Number: 410743

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### general U.S. population and 56 % of th e cPAD for children 1

- 2 years old, the most highly exposed population subgroup.

IX. List of Attachments

1. Revised and Proposed Tolerances Included in this Assessment 2. Chronic Residue Input File 3. Chronic Dietary (Food and Drinking Water) Results F ile 4. Boscalid Screening Level Usage Analysis (SLUA)

.Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

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### ATTACHMENT 1

. Revised and Recommended Tolerances Included in this Assessment

Tolerance Summary for Boscalid 1, 2 Commodity Proposed /Existing Tolerance (ppm) Recommended / Harmonized Toleranc e (ppm) Comments; Correct Commodity

Definition

40 CFR 180.589(a) General

. It is recommended that t olerances be established for residues of the fungicide boscalid, including its metabolites and degradates, in or on the commodities listed below. Complian ce with the tolerance levels specified below is to be determined by measuring only boscalid, 3

- pyridinecarboxamide, 2

- chloro

- N

- (4 ′

- chloro[1,1'

- biphenyl]

- 2

- yl), in or on the following raw agricultural commodities: Artichoke, globe 6.0 6.0 Endive, Belgi um 5.0 6.0 OECD statistical calculation estimates 6.0 ppm
Persimmon 7.0 8.0 OECD statistical calculation estimates 8.0 ppm Vegetable, bulb, group 3

- 07 3.0 5.0 Group update. Harmonization with Codex (VA 0035 Bulb vegetables: 5 mg/kg) Vegetable, bulb , group 3 3.0 Remove Group update. Vegetable, fruiting, group 8

- 10 1.2 3.0 Group update. Harmonization with Codex (Fruiting vegetables other than cucurbits VO 0050: 3 mg/kg) Vegetable, fruiting, group 8 1.2 Remove Group update. Fruit, citrus, group 10

- 1 0 1.6 2.0 Group update. Harmonization with Codex (Citrus fruits FC 0001: 2 mg/kg) Fruit, citrus, group 10 1.6 Remove Group update. Fruit, pome, group 11

- 10 3.0 3.0 Group update. Fruit, pome, group 11 3.0 Remove Group update. Caneberry subgroup 13

- 07A 6 .0 10.0 Subgroup update. Harmonization with Codex (Berries and other small fruits, FB 0018: 10 mg/kg) Caneberry subgroup 13A 6.0 Remove Subgroup update. Bushberry subgroup 13

- 07B 13.0 13.0 Subgroup update. Bushberry subgroup 13B 13.0 Remove Subgroup up date. Fruit, small, vine climbing, except fuzzy kiwifruit, subgroup 13

- 07F 3.5 5.0 Subgroup update. Harmonization with Codex (Grapes FB 0269: 5 mg/kg) Grape 3.5 Remove Group update. See subgroup 13

- 07F. Berry, low growing, subgroup 13

- 07G except cranb erry 4.5 4.5 Subgroup update.

Strawberry 4.5 Remove Group update. See subgroup 13

- 07G.Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

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Page 12 of 24 Tolerance Summary for Boscalid 1, 2 Commodity Proposed /Existing Tolerance (ppm) Recommended / Harmonized Toleranc e (ppm) Comments; Correct Commodity

Definition

Oilseed group 20 3.5 5.0 Group update. Harmonization with Canada (canola oil and mustard seed oil, 5.0 ppm) Canola, seed 3.5 Remove Group update. See group 20.
Sun flower, seed 0.60 Remove Group update. See group 20. Cotton, undelinted seed 1.0 Remove Group update. See group 20. Vegetable, root, except sugarbeet, subgroup 1B 1.0 2.0 Vegetable, root, except sugarbeet, subgroup 1B, except garden beet, radish, and t urnip. Subgroup update. Harmonization with Codex (Root and tuber vegetables, VR 0075: 2 mg/kg) Vegetable, root subgroup 1A, except sugarbeet, garden beet, radish, and turnip 1.0 Remove Group update.

Turnip, greens 18.0 40.0 Turnip, tops Translation of data from mustard greens, for which a tolerance of 18.0 ppm exists ( Brassica leafy greens). Harmonization with Codex (Leafy vegetables VL 0053: 40 mg/kg) 40 CFR 180.589( b ) Section 18 emergency exemptions Endive, Belgian 16 Remove Replaced by tolerance under 40 CFR 180.589(a) 40 CFR 180.589( d ) Indirect or inadvertent residues Flax, seed 3.5 Remove Group update. See group 20. Cotton, gin byproducts 0.30 Remove Duplicate of existing 40 CFR 180.589(a) entry.
1 In addition, 0.5 ppm for honey was entered into the dietary contribution based on a tolerance of 0.5 ppm in the European Union.
2 Tolerances that have not been revised/changed are not listed in this table. For example, livestock commodity tolerances (meat, milk, poultry, and eggs) are not listed b ecause they did not change from the previous evaluation.Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

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### ATTACHMENT 2

. Chronic Residue Input File

Filename: C: \ Documents and Settings \ sfunk \ My Documents \ DEEMversion3.16 \ BOSCALIDchronic_06_20_13.R08 Chemical: BAS 510F RfD(Chronic): .218 mg/ kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 06

- 20

- 2013/15:10:37 Program ver. 3.16, 03

- 08

- d

--------------------------------------------------------------------

--------- ------ EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ---

---- 140000 3000 14 Almond 0.700000 1.000 0.400 1400004000 14 Almond, oil 0.700000 1.000 0.400 1400004001 14 Almond, oil

- babyfood 0.700000 1.000 0.400 1400003001 14 Almond

- babyfood 0.700000 1.000 0.400 0401005000 4A Amaranth, leafy 60.000000 1.000 1.000 1100009000 11 Apple, dried 3.000000 8.000 0.150 1100009001 11 Apple, dried

- babyfood 3.000 000 8.000 0.150 1100007000 11 Apple, fruit with peel 3.000000 1.000 0.150 1100010000 11 Apple, juice 3.000000 1.000 0.150 1100010001 11 Apple, juice

- babyfood 3.000000 1.000 0.150 1100 008000 11 Apple, peeled fruit 3.000000 1.000 0.150 1100008001 11 Apple, peeled fruit

- babyfood 3.000000 1.000 0.150 1100011000 11 Apple, sauce 3.000000 1.000 0.150 1100011001 11 Apple, sauce

- babyfood 3.000000 1.000 0.150 1202012000 12B Apricot 3.500000 1.000 0.250 1202013000 12B Apricot, dried 3.500000 6.000 0.250 1202014000 12B Apricot, juice 3.5 00000 1.000 0.250 1202014001 12B Apricot, juice

- babyfood 3.500000 1.000 0.250 1202012001 12B Apricot

- babyfood 3.500000 1.000 0.250 0103015000 1CD Arrowroot, flour 2.000000 1.000 1.000 01 03015001 1CD Arrowroot, flour

- babyfood 2.000000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.050000 1.000 1.000 9500016000 O Artichoke, globe 6.000000 1.000 1.000 0401018000 4A Arugula 60.000000 1.000 1.000 9500020000 O Avocado 1.500000 1.000 1.000 0902021000 9B Balsam pear 1.600000 1.000 1.000 9500023000 O Banana 0 .400000 1.000 1.000 9500024000 O Banana, dried 0.400000 3.900 1.000 9500024001 O Banana, dried

- babyfood 0.400000 3.900 1.000 9500023001 O Banana

- babyfood 0.400000 1.000 1.000 1500027000 15 Barley, bran 0.200000 1.000 1.000 1500026000 15 Barley, flour 0.200000 1.000 1.000 1500026001 15 Barley, flour

- babyfood 0.200000 1.000 1.000 1500025000 15 Barley, p earled barley 0.200000 1.000 1.000 1500025001 15 Barley, pearled barley

- babyfood 0.200000 1.000 1.000 1901029000 19A Basil, dried leaves 190.000000 1.000 1.000 1901029001 19A Basil, dried leaves

- babyfood 1 90.000000 1.000 1.000 1901028000 19A Basil, fresh leaves 40.000000 1.000 1.000 1901028001 19A Basil, fresh leaves

- babyfood 40.000000 1.000 1.000 0603035000 6C Bean, great northern, seed 2.500000 1.000 0.025 0603030000 6C Bean, black, seed 2.500000 1.000 0.025 0603032000 6C Bean, broad, seed 2.500000 1.000 0.025 0602031000 6B Bean, broad, succulent 0.600000 1.000 1.000Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

PC Code: 128008

Page 14 of 24 0603034000 6C Bean, c owpea, seed 2.500000 1.000 0.025 0603036000 6C Bean, kidney, seed 2.500000 1.000 0.025 0603038000 6C Bean, lima, seed 2.500000 1.000 0.025 0602037000 6B Bean, lima, succulent 0.600000 1.000 1.000 0603039000 6C Bean, mung, seed 2.500000 1.000 0.025 0603040000 6C Bean, navy, seed 2.500000 1.000 0.025 0603041000 6C Bean, pink, seed 2.500000 1.000 0.02 5 0603042000 6C Bean, pinto, seed 2.500000 1.000 0.025 0601043000 6A Bean, snap, succulent 1.600000 1.000 0.050 0601043001 6A Bean, snap, succulent

- babyfood 1.600000 1.000 0.050 3100047000 31 Beef, fat 0.300000 1.000 1.000 3100047001 31 Beef, fat

- babyfood 0.300000 1.000 1.000 3100048000 31 Beef, kidney 0.350000 1.000 1.000 3100049000 31 Beef, liver 0.350000 1.000 1.000 3100049001 31 Beef, liver

- babyfood 0.350000 1.000 1.000 3100044000 31 Beef, meat 0.100000 1.000 1.000 3100046000 31 Beef, meat byproducts 0.350000 1.000 1. 000 3100046001 31 Beef, meat byproducts

- babyfood 0.350000 1.000 1.000 3100045000 31 Beef, meat, dried 0.100000 1.920 1.000 3100044001 31 Beef, meat

- babyfood 0.100000 1.000 1.000 0101050000 1AB Bee t, garden, roots 0.100000 1.000 1.000 0101050001 1AB Beet, garden, roots

- babyfood 0.100000 1.000 1.000 0200051000 2 Beet, garden, tops 0.100000 1.000 1.000 0101052000 1A Beet, sugar 0.100000 1.000 1.000 0101053000 1A Beet, sugar, molasses 0.100000 1.000 1.000 0101053001 1A Beet, sugar, molasses

- babyfood 0.100000 1.000 1.000 0101052001 1A Beet, sugar

- babyfood 0.100000 1.000 1.000 9500054000 O Belgium endive 6.000000 1.000 1.000 1301055000 13A Blackberry 10.000000 1.000 0.450 1301056000 13A Blackberry, juice 10.000000 1.000 0.450 1301056001 13A B lackberry, juice

- babyfood 10.000000 1.000 0.450 1302057000 13B Blueberry 13.000000 1.000 0.350 1302057001 13B Blueberry

- babyfood 13.000000 1.000 0.350 1301058000 13A Boysenberry 10.000000 1.000 0.450 1400059000 14 Brazil nut 0.700000 1.000 1.000 0501061000 5A Broccoli 3.000000 1.000 0.025 0502063000 5B Broccoli raab 18.000000 1.000 1.000 0501062000 5A Broccoli, Chinese 3.000000 1.000 1.000 0501061001 5A Broccoli

- babyfood 3.000000 1.000 0.025 0501064000 5A Brussels sprouts 3.000000 1.000 1.000 1500065000 15 Buckwheat 0.200000 1.000 1.000 1500066000 15 Buckwheat, flour 0.200000 1.000 1.000 0101067000 1AB Burdock 2.000000 1.000 1.000 1400068000 14 Butternut 0.700000 1.000 1.000 0501069000 5A Cabbage 3.000000 1.000 0.050 0502070000 5B Cabbage, Chinese, bok choy 18.000000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 3.000000 1.0 00 1.000 0501071000 5A Cabbage, Chinese, napa 3.000000 1.000 1.000 9500074000 O Canistel 1.500000 1.000 1.000 0901075000 9A Cantaloupe 1.600000 1.000 0.050 0402076000 4B Cardoon 45.000000 1.000 1.000 0101078000 1AB Carrot 2.000000 1.000 0.150 0101079000 1AB Carrot, juice 2.000000 1.000 0.150 0101078001 1AB Carrot

- babyfood 2.000000 1.000 0.150 1400081000 14 Cashew 0.700000 1.000 1.000 0103082000 1CD Cassava 0.050000 1.000 1.000 0103082001 1CD Cassava

- babyfood 0.050000 1 .000 1.000 0501083000 5A Cauliflower 3.000000 1.000 0.050 0101084000 1AB Celeriac 2.000000 1.000 1.000 0402085000 4B Celery 45.000000 1.000 0.025 0402086000 4B Celery, juice 45.000000 1.000 0.025 0402085001 4B Celery

- babyfood 45.000000 1.000 0.025 0402087000 4B Celtuce 45.000000 1.000 1.000Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

PC Code: 128008

Page 15 of 24 0902088000 9B Chayote, fruit 1.600000 1.000 1.000 1201090000 12A Cherry 3.500000 1.000 0.450 1201091000 12A Cherry, juice 3.500000 1.500 0.450 1201091001 12A Cherry, juice

- babyfood 3.500000 1.500 0.450 1201090001 12A Cherry

- babyfood 3.500000 1.000 0.450 1400092000 14 Chestnut 0.700000 1.000 1.000 4000096000 40 Chicken, fat 0.200000 1.000 1.000 400009600 1 40 Chicken, fat

- babyfood 0.200000 1.000 1.000 4000094000 40 Chicken, liver 0.200000 1.000 1.000 4000093000 40 Chicken, meat 0.050000 1.000 1.000 4000095000 40 Chicken, meat bypr oducts 0.200000 1.000 1.000 4000095001 40 Chicken, meat byproducts

- babyfoo 0.200000 1.000 1.000 4000093001 40 Chicken, meat

- babyfood 0.050000 1.000 1.000 4000097000 40 Chicken, skin 0.200000 1.000 1.000 4000097001 40 Chicken, skin

- babyfood 0.200000 1.000 1.000 0603099000 6C Chickpea, flour 2.500000 1.000 0.025 0603098000 6C Chickpea, seed 2.500000 1.000 0.025 0603098 001 6C Chickpea, seed

- babyfood 2.500000 1.000 0.025 0101100000 1AB Chicory, roots 2.000000 1.000 1.000 0200101000 2 Chicory, tops 0.100000 1.000 1.000 0902102000 9B Chinese waxgourd 1.600000 1.000 1.000 0302103000 3B Chive, fresh leaves 40.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 60.000000 1.000 1.000 1901118000 19A Cilantro, leaves 40.0000 00 1.000 1.000 1901118001 19A Cilantro, leaves

- babyfood 40.000000 1.000 1.000 1001106000 10A Citron 2.000000 1.000 1.000 1001107000 10A Citrus hybrids 2.000000 1.000 1.000 10011 08000 10A Citrus, oil 85.000000 1.000 1.000 2003114001 20C Coconut, oil

- babyfood 5.000000 1.000 1.000 9500116000 O Coffee, instant 0.050000 1.000 1.000 9500115000 O Coffee, roaste d bean 0.050000 1.000 1.000 0502117000 5B Collards 18.000000 1.000 1.000 1500122000 15 Corn, field, bran 0.200000 1.000 1.000 1500120000 15 Corn, field, flour 0.20 0000 1.000 1.000 1500120001 15 Corn, field, flour

- babyfood 0.200000 1.000 1.000 1500121000 15 Corn, field, meal 0.200000 1.000 1.000 1500121001 15 Corn, field, meal

- babyfood 0.200000 1.000 1.000 150 0125000 15 Corn, field, oil 0.200000 1.000 1.000 1500125001 15 Corn, field, oil

- babyfood 0.200000 1.000 1.000 1500123000 15 Corn, field, starch 0.200000 1.000 1.000 1500123001 15 Corn, field, starch

- babyfood 0.200000 1.000 1.000 1500124000 15 Corn, field, syrup 0.200000 1.500 1.000 1500124001 15 Corn, field, syrup

- babyfood 0.200000 1.500 1.000 1500126000 15 Corn, pop 0. 200000 1.000 1.000 1500127000 15 Corn, sweet 0.200000 1.000 1.000 1500127001 15 Corn, sweet

- babyfood 0.200000 1.000 1.000 2003128000 20C Cottonseed, oil 5.000000 1.000 1.000 2 003128001 20C Cottonseed, oil

- babyfood 5.000000 1.000 1.000 1100129000 11 Crabapple 3.000000 1.000 1.000 0401133000 4A Cress, garden 60.000000 1.000 1.000 0401134000 4A Cress, upl and 60.000000 1.000 1.000 0902135000 9B Cucumber 0.500000 1.000 0.050 1302136000 13B Currant 13.000000 1.000 1.000 1302137000 13B Currant, dried 1 3.000000 1.000 1.000 0401138000 4A Dandelion, leaves 60.000000 1.000 1.000 0103139000 1CD Dasheen, corm 0.050000 1.000 1.000 0200140000 2 Dasheen, leaves 0.100000 1.000 1.000 1902143000 19B Dill, seed 140.000000 1.000 1.000 1901144000 19A Dillweed 40.000000 1.000 1.000 7000146000 70 Egg, white 0.020000 1.000 1.000 7000146001 70 Egg, whi te (solids)

- babyfood 0.020000 1.000 1.000 7000145000 70 Egg, whole 0.020000 1.000 1.000 7000145001 70 Egg, whole

- babyfood 0.020000 1.000 1.000Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

PC Code: 128008

Page 16 of 24 7000147000 70 Egg, yolk 0.020000 1.000 1.000 7000147001 70 Egg, yolk

- babyfood 0.020000 1.000 1.000 0802148000 8BC Eggplant 3.000000 1.000 1.000 1302149000 13B Elderberry 13.000000 1.000 1.000 0401150000 4A Endive 60.000000 1.000 1.000 0402152000 4B Fennel, Florence 45.000000 1.000 1.000 2001163000 20A Flax seed, oil 5.000000 1.000 1.000 0301165000 3A Garlic , bulb 5.000000 1.000 0.050 0301165001 3A Garlic, bulb

- babyfood 5.000000 1.000 0.050 0103166000 1CD Ginger 0.050000 1.000 1.000 0103167000 1CD Ginger, dried 0.050000 1.000 1.000 0103166001 1CD Ginger

- babyfood 0.050000 1.000 1.000 0101168000 1AB Ginseng, dried 2.000000 1.000 1.000 3200171000 32 Goat, fat 0.300000 1.000 1.0 00 3200172000 32 Goat, kidney 0.350000 1.000 1.000 3200173000 32 Goat, liver 0.350000 1.000 1.000 3200169000 32 Goat, meat 0.100000 1.000 1.000 3200170000 32 Goat , meat byproducts 0.350000 1.000 1.000 1100173500 11 Goji berry 3.000000 1.000 1.000 1302174000 13B Gooseberry 13.000000 1.000 1.000 1304175000 13D Grape 5.000000 1.000 0.300 1304176000 13D Grape, juice 5.000000 1.200 0.300 1304176001 13D Grape, juice

- babyfood 5.000000 1.200 0.300 9500177000 O Grape, leaves 3.500000 1.000 0 .300 9500178000 O Grape, raisin 8.500000 1.000 0.300 1304179000 13D Grape, wine and sherry 5.000000 1.000 0.300 1003180000 10C Grapefruit 2.000000 1.000 1.000 1003181000 10C Gr apefruit, juice 2.000000 1.000 1.000 0603182000 6C Guar, seed 2.500000 1.000 0.025 0603182001 6C Guar, seed

- babyfood 2.500000 1.000 0.025 1400155000 14 Hazelnut 0.700000 1.000 0.050 1400156000 14 Hazelnut, oil 0.700000 1.000 0.050 1901184000 19A Herbs, other 40.000000 1.000 1.000 1901184001 19A Herbs, other

- babyfood 40.000000 1.000 1.000 1400185000 14 Hickory nut 0.700000 1.000 1.000 9500186000 O Honey 0.500000 1.000 1.000 9500186001 O Honey

- babyfood 0.500000 1.000 1.000 0901187000 9A Honeydew melon 1.600000 1.000 1.000 9500188000 O Hop 35.000000 1.000 1.000 3300189000 33 Horse, meat 0.100000 1.000 1.000 0101190000 1AB Horseradish 2.000000 1.000 1.000 1302191000 13B Huckleberry 13.000000 1.000 1.000 0502194000 5B Kale 18.000000 1.000 1.000 0501196000 5A Kohlrabi 3.000000 1.00 0 1.000 1002197000 10B Kumquat 2.000000 1.000 1.000 0302198000 3B Leek 5.000000 1.000 1.000 1002199000 10B Lemon 2.000000 1.000 1.000 1002200000 10B Lemon, juice 2.000000 1.000 1.000 1002200001 10B Lemon, juice

- babyfood 2.000000 1.000 1.000 1002201000 10B Lemon, peel 2.000000 1.000 1.000 1901202000 19A Lemongrass 40.000000 1.000 1.000 0603203000 6C Lentil, seed 2.500000 1.000 0.025 0401204000 4A Lettuce, head 6.500000 1.000 0.250 0401205000 4A Lettuce, leaf 11.000000 1. 000 0.250 1002206000 10B Lime 2.000000 1.000 1.000 1002207000 10B Lime, juice 2.000000 1.000 1.000 1002207001 10B Lime, juice

- babyfood 2.000000 1.000 1.000 1301208000 1 3A Loganberry 10.000000 1.000 1.000 1100210000 11 Loquat 3.000000 1.000 1.000 1400213000 14 Macadamia nut 0.700000 1.000 1.000 9500215000 O Mango 1.500000 1.000 1.000 9500216000 O Mango, dried 1.500000 1.000 1.000 9500217000 O Mango, juice 1.500000 1.000 1.000Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

PC Code: 128008

Page 17 of 24 9500217001 O Mango, juice

- babyfood 1.500000 1.000 1.000 9500215001 O Mango

- babyfood 1.500000 1.000 1.000 1901220000 19A Marjoram 40.000000 1.000 1.000 1901220001 19A Marjoram

- babyfood 40.000000 1.000 1.000 3800221000 38 Meat, game 0.100000 1.000 1.000 3600222000 36 Milk, fat 0.100000 1.000 1.000 3600222001 36 Milk, fat

- baby food/infant formu 0.100000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.100000 1.000 1.000 3600223001 36 Milk, nonfat solids

- baby food/in 0.100000 1.000 1.000 3600225001 36 Milk, sugar (lactose)

- baby food/ 0.100000 1.000 1.000 3600224000 36 Milk, water 0.100000 1.000 1.000 3600224001 36 Milk, water

- babyfood/infant form 0.100000 1.000 1.000 1500226000 15 Millet, grain 0.200000 1.000 1.000 0502229000 5B Mustard greens 18.000000 1.000 1.000 12022300 00 12B Nectarine 3.500000 1.000 0.150 1500231000 15 Oat, bran 0.200000 1.000 1.000 1500232000 15 Oat, flour 0.200000 1.000 1.000 1500232001 15 Oat, flour

- babyfo od 0.200000 1.000 1.000 1500233000 15 Oat, groats/rolled oats 0.200000 1.000 1.000 1500233001 15 Oat, groats/rolled oats

- babyfood 0.200000 1.000 1.000 0802234000 8BC Okra 3.00000 0 1.000 1.000 0301237000 3A Onion, bulb 5.000000 1.000 0.200 0301238000 3A Onion, bulb, dried 5.000000 9.000 0.200 0301238001 3A Onion, bulb, dried

- babyfood 5.000000 9.000 0.200 030123 7001 3A Onion, bulb

- babyfood 5.000000 1.000 0.200 0302239000 3B Onion, green 5.000000 1.000 0.200 1001240000 10A Orange 2.000000 1.000 1.000 1001241000 10A Orange, juice 2.000000 1.000 1.000 1001241001 10A Orange, juice

- babyfood 2.000000 1.000 1.000 1001242000 10A Orange, peel 2.000000 1.000 1.000 9500245000 O Papaya 1.500 000 1.000 1.000 9500246000 O Papaya, dried 1.500000 1.800 1.000 9500247000 O Papaya, juice 1.500000 1.500 1.000 9500245001 O Papaya

- babyfood 1.500000 1.000 1.000 1901 249000 19A Parsley, dried leaves 190.000000 1.000 1.000 1901249001 19A Parsley, dried leaves

- babyfood 190.000000 1.000 1.000 0401248000 4A Parsley, leaves 60.000000 1.000 1.000 0101250000 1AB Parsley, turn ip rooted 2.000000 1.000 1.000 0101251000 1AB Parsnip 2.000000 1.000 1.000 0101251001 1AB Parsnip

- babyfood 2.000000 1.000 1.000 0603256000 6C Pea, dry 2.5 00000 1.000 0.025 0603256001 6C Pea, dry

- babyfood 2.500000 1.000 0.025 0601257000 6A Pea, edible podded, succulent 1.600000 1.000 1.000 0603258000 6C Pea, pigeon, seed 2.500000 1.000 0.025 06 02259000 6B Pea, pigeon, succulent 0.600000 1.000 1.000 0602255000 6B Pea, succulent 0.600000 1.000 0.010 0602255001 6B Pea, succulent

- babyfood 0.600000 1.000 0.010 1202260000 12B Peach 3.500000 1.000 0.200 1202261000 12B Peach, dried 3.500000 7.000 0.200 1202261001 12B Peach, dried

- babyfood 3.500000 7.000 0.200 1202262000 12B Peach, juice 3 .500000 1.000 0.200 1202262001 12B Peach, juice

- babyfood 3.500000 1.000 0.200 1202260001 12B Peach

- babyfood 3.500000 1.000 0.200 9500263000 O Peanut 0.050000 1.000 0.010 9500264000 O Peanut, butter 0.050000 1.890 0.010 9500265000 O Peanut, oil 0.150000 1.000 0.010 1100266000 11 Pear 3.000000 1.000 0.150 1100267000 11 Pear, dri ed 3.000000 6.250 0.150 1100268000 11 Pear, juice 3.000000 1.000 0.150 1100268001 11 Pear, juice

- babyfood 3.000000 1.000 0.150 1100266001 11 Pear

- babyfood 3.000000 1.000 0.150 1400269000 14 Pecan 0.700000 1.000 1.000 0802270000 8B Pepper, bell 3.000000 1.000 0.025Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

PC Code: 128008

Page 18 of 24 0802271000 8B Pepper, bell, dried 3.000000 1.000 0.025 0802271001 8B Pepper, bell, dried

- babyfood 3.000000 1.000 0.025 0802270001 8B Pepper, bell

- babyfood 3.000000 1.000 0.025 0802272000 8BC Pepper, nonbell 3.000000 1.000 0.025 0802273000 8BC Pepper, nonbell, dried 3.000000 1.000 0.025 0802272001 8BC Pepper, nonbell

- babyfood 3.000000 1.000 0.025 9500275000 O Peppermint 30.000000 1.000 1.000 9500276000 O Peppermint, oil 30.000000 1.000 1.000 9500277000 O Persimmon 8.000000 1.000 1.000 1400282000 14 Pistachio 0.700000 1.000 0.300 9500283000 O Plantain 0.400000 1.000 1.00 0 9500284000 O Plantain, dried 0.400000 3.900 1.000 1203285000 12C Plum 3.500000 1.000 0.050 1203287000 12C Plum, prune, dried 3.500000 1.000 0.050 1203287001 12C Plum, prune, dried

- babyfood 3.500000 1.000 0.050 1203286000 12C Plum, prune, fresh 3.500000 1.000 0.050 1203286001 12C Plum, prune, fresh

- babyfood 3.500000 1.000 0.050 1203288000 12C Plum, prune, juice 3.500000 1.400 0.050 1203288001 12C Plum, prune, juice

- babyfood 3.500000 1.400 0.050 1203285001 12C Plum

- babyfood 3.500000 1.000 0.050 3400293000 34 Pork, fat 0.200000 1.000 1. 000 3400293001 34 Pork, fat

- babyfood 0.200000 1.000 1.000 3400294000 34 Pork, kidney 0.100000 1.000 1.000 3400295000 34 Pork, liver 0.100000 1.000 1.000 3400290000 34 Por k, meat 0.050000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.100000 1.000 1.000 3400292001 34 Pork, meat byproducts

- babyfood 0.100000 1.000 1.000 3400290001 34 Pork, meat

- babyfood 0.050000 1.000 1.000 3400291000 34 Pork, skin 0.100000 1.000 1.000 0103296000 1C Potato, chips 0.050000 1.000 0.200 0103297000 1C Potato, dry (granules/ flakes) 0.050000 6.500 0.200 0103297001 1C Potato, dry (granules/ flakes)

- b 0.050000 6.500 0.200 0103298000 1C Potato, flour 0.050000 6.500 0.200 0103298001 1C Potato, flour

- babyfood 0.050000 6.500 0.200 0103300000 1C P otato, tuber, w/o peel 0.050000 1.000 0.200 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.050000 1.000 0.200 0103299000 1C Potato, tuber, w/peel 0.050000 1.000 0.200 0103299001 1C Potato, tuber, w/peel

- baby food 0.050000 1.000 0.200 6000304000 60 Poultry, other, fat 0.200000 1.000 1.000 6000302000 60 Poultry, other, liver 0.200000 1.000 1.000 6000301000 60 Poultry, other, meat 0.050000 1.000 1.000 6000303000 60 Poultry, other, meat byproducts 0.200000 1.000 1.000 6000305000 60 Poultry, other, skin 0.200000 1.000 1.000 1003307000 10C Pummelo 2.000000 1.000 1.000 0902308000 9B Pumpkin 1.600000 1.000 0.100 0902309000 9B Pumpkin, seed 1.600000 1.000 0.100 1100310000 11 Quince 3.000000 1.000 1.000 3900312000 39 Rabbit, meat 0.100000 1.000 1.000 0401313000 4A Radicchio 60.000000 1.000 1.000 0101316000 1AB Radish, Oriental, roots 2.000000 1.000 1.000 0200317000 2 Radish, Oriental, tops 0.100000 1.0 00 1.000 0101314000 1AB Radish, roots 0.100000 1.000 1.000 0200315000 2 Radish, tops 0.100000 1.000 1.000 0502318000 5B Rape greens 18.000000 1.000 1.000 2001319000 20 A Rapeseed, oil 5.000000 1.000 1.000 2001319001 20A Rapeseed, oil

- babyfood 5.000000 1.000 1.000 1301320000 13A Raspberry 10.000000 1.000 0.450 1301321000 13A Raspberry, juice 10.000000 1.000 0.450 1301321001 13A Raspberry, juice

- babyfood 10.000000 1.000 0.450 1301320001 13A Raspberry

- babyfood 10.000000 1.000 0.450 0402322000 4B Rhubarb 45.000000 1 .000 1.000 1500326000 15 Rice, bran 0.200000 1.000 1.000 1500326001 15 Rice, bran

- babyfood 0.200000 1.000 1.000Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

PC Code: 128008

Page 19 of 24 1500324000 15 Rice, brown 0.200000 1.000 1.000 1500324001 15 Rice, brown

- babyfood 0.200000 1.000 1.000 1500325000 15 Rice, flour 0.200000 1.000 1.000 1500325001 15 Rice, flour

- babyfood 0.200000 1.000 1.000 1500323000 15 Rice, white 0.200000 1.000 1.000 1500323001 15 Rice, white

- babyfood 0.200000 1.000 1.000 0101327000 1AB Rutabaga 2.000000 1.000 1.000 1500329000 15 Rye, flour 0.200000 1.000 1.000 1500328000 15 Rye, grain 0.200000 1.000 1.000 2002330000 20B Safflower, oil 5.000000 1.000 1.000 2002330001 20B Safflower, oil

- babyfood 5.000000 1.000 1.000 010133100 0 1AB Salsify, roots 2.000000 1.000 1.000 0200332000 2 Salsify, tops 0.100000 1.000 1.000 9500333000 O Sapote, Mamey 1.500000 1.000 1.000 1901334000 19A Savory 40.000000 1.000 1.000 2001337000 20A Sesame, oil 5.000000 1.000 1.000 2001337001 20A Sesame, oil

- babyfood 5.000000 1.000 1.000 2001336000 20A Sesame, seed 5.000000 1.000 1.000 2001336001 20A Sesame, seed

- babyfood 5.000000 1.000 1.000 0301338000 3A Shallot, bulb 5.000000 1.000 1.000 0302338500 3B Shallot, fresh leaves 5.000000 1.000 1.000 3500341 000 35 Sheep, fat 0.300000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.300000 1.000 1.000 3500342000 35 Sheep, kidney 0.350000 1.000 1.000 3500343000 35 Sheep, liver 0.350000 1.000 1.000 3500339000 35 Sheep, meat 0.100000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.350000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.1000 00 1.000 1.000 1500344000 15 Sorghum, grain 0.200000 1.000 1.000 1500345000 15 Sorghum, syrup 0.200000 1.000 1.000 0603348000 6C Soybean, flour 0.100000 1.000 1.000 06033 48001 6C Soybean, flour

- babyfood 0.100000 1.000 1.000 0600350000 6 Soybean, oil 0.100000 1.000 1.000 0600350001 6 Soybean, oil

- babyfood 0.100000 1.000 1.000 0600347000 6 Soybean, seed 0.100000 1.000 1.000 0600349000 6 Soybean, soy milk 0.100000 1.000 1.000 0600349001 6 Soybean, soy milk

- babyfood or in 0.100000 1.000 1.000 0601349500 6AB Soybean, vegetable 2.00 0000 1.000 1.000 9500352000 O Spearmint 30.000000 1.000 1.000 9500353000 O Spearmint, oil 30.000000 1.000 1.000 0401355000 4A Spinach 60.000000 1.000 1.000 040 1355001 4A Spinach

- babyfood 60.000000 1.000 1.000 0902356000 9B Squash, summer 1.600000 1.000 0.050 0902356001 9B Squash, summer

- babyfood 1.600000 1.000 0.050 0902357000 9B Squash, wint er 1.600000 1.000 0.050 0902357001 9B Squash, winter

- babyfood 1.600000 1.000 0.050 1307359000 13G Strawberry 4.500000 1.000 0.550 1307360000 13G Strawberry, juice 4. 500000 1.000 0.550 1307360001 13G Strawberry, juice

- babyfood 4.500000 1.000 0.550 1307359001 13G Strawberry

- babyfood 4.500000 1.000 0.550 2002365000 20B Sunflower, oil 5.000000 1.000 1.000 2 002365001 20B Sunflower, oil

- babyfood 5.000000 1.000 1.000 2002364000 20B Sunflower, seed 5.000000 1.000 1.000 0103366000 1CD Sweet potato 0.050000 1.000 1.000 0103366001 1CD Sweet pota to

- babyfood 0.050000 1.000 1.000 0402367000 4B Swiss chard 45.000000 1.000 1.000 1001369000 10A Tangerine 2.000000 1.000 1.000 1001370000 10A Tangerine, juice 2.000000 2.300 1.000 0103371000 1CD Tanier, corm 0.050000 1.000 1.000 0801374000 8A Tomatillo 3.000000 1.000 1.000 0801375000 8A Tomato 3.000000 1.000 0.050 0801380000 8A Tomato, Tree 3.000000 1.000 1.000 0801378000 8A Tomato, dried 3.000000 14.300 0.050Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

PC Code: 128008

Page 20 of 24 0801378001 8A Tomato, dried

- babyfood 3.000000 14.300 0.050 0801379000 8A Tomato, juice 3.000000 1.000 0.050 0801376000 8A Tomato, paste 3.000000 1.000 0.050 0801376001 8A Tomato, paste

- babyfood 3.000000 1.000 0.050 0801377000 8A Tomato, puree 3.000000 1.000 0.050 0801377001 8A Tomato, puree

- babyfood 3.000000 1.000 0.050 0801375001 8A Tomato

- babyfood 3.000000 1.000 0.050 1500381000 15 Triticale, flour 0.200000 1.000 1.000 1500381001 15 Triticale, flour

- babyfood 0.200000 1.000 1.000 5000385000 50 Turkey, fat 0.200000 1.000 1.000 5000385001 50 Turkey, fat

- babyfood 0.200000 1.000 1.000 5000383000 50 Turkey , liver 0.200000 1.000 1.000 5000383001 50 Turkey, liver

- babyfood 0.200000 1.000 1.000 5000382000 50 Turkey, meat 0.050000 1.000 1.000 5000384000 50 Turkey, meat byproducts 0.200000 1.000 1.000 5000384001 50 Turkey, meat byproducts

- babyfood 0.200000 1.000 1.000 5000382001 50 Turkey, meat

- babyfood 0.050000 1.000 1.000 5000386000 50 Turkey, skin 0.200000 1.000 1.0 00 5000386001 50 Turkey, skin

- babyfood 0.200000 1.000 1.000 0103387000 1CD Turmeric 0.050000 1.000 1.000 0502389000 5B Turnip, greens 40.000000 1.000 1.000 0101388000 1AB Turn ip, roots 0.100000 1.000 1.000 1400391000 14 Walnut 0.700000 1.000 0.010 8601000000 86A Water, direct, all sources 0.697000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.697000 1.000 1.000 0901399000 9A Watermelon 1.600000 1.000 0.250 0901400000 9A Watermelon, juice 1.600000 1.000 0.250 1500404000 15 Wheat, bran 0.200000 1.000 1 .000 1500402000 15 Wheat, flour 0.200000 1.000 1.000 1500402001 15 Wheat, flour

- babyfood 0.200000 1.000 1.000 1500403000 15 Wheat, germ 0.200000 1.000 1.000 1500401000 15 Wh eat, grain 0.200000 1.000 1.000 1500401001 15 Wheat, grain

- babyfood 0.200000 1.000 1.000 1500405000 15 Wild rice 0.200000 1.000 1.000 0103407000 1CD Yam bean 0.050000 1.000 1.000 0103406000 1CD Yam, true 0.050000 1.000 1.000Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

PC Code: 128008

Page 21 of 24 

### ATTACHMENT 3

. Chronic Dietary (Food and Drinking Water) Results File

US EPA Ver. 3.16, 03

- 08

- d
DEEM

- FCID Chronic analysis for BAS 510F NHANES 2003

- 2008 2

- day Residue file name: C: \ Documents and Settings \ sfunk \ My Documents \ DEEMversion3.16 \ BOSCALIDchronic_06_20_13.R08

. Adjustment factor #2 NOT used.

Analysis D ate 06

- 23

- 2013/09:58:20 Residue file dated: 06

- 23

- 2013/09:56:35 Reference dose (RfD, Chronic) = .218 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.042751 19.6% Hispanic 0.044165 20.3%
Non

- Hisp

- White 0.042578 19.5%
Non

- Hisp

- Black 0.038313 17.6%
Non

- Hisp

- Other 0.052006 23.9% Nursing Infants 0.045956 21.1%
Non

- Nursing Infants 0.111232 51.0% Female 13+ PREG 0.038 279 17.6% Children 1

- 6 0.096979 44.5% Children 7

- 12 0.043756 20.1% Male 13

- 19 0.029090 13.3% Female 13

- 19/NP 0.030514 14.0% Male 20+ 0.035066 16.1% Female 20+/NP 0.039255 18.0% Seniors 55+ 0.037974 17.4% All Infants 0.091079 41.8% Female 13

- 50 0.036893 16.9% Children 1

- 2 0.121118 55.6% Chi ldren 3

- 5 0.088299 40.5% Children 6

- 12 0.047744 21.9% Youth 13

- 19 0.029796 13.7% Adults 20

- 49 0.036670 16.8% Adults 50

- 99 0.038128 17.5% Female 13

- 49 0.036806 16.9%

---------------------------------------------------------------------- ---------Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

PC Code: 128008

Page 22 of 24 

### ATTACHMENT 4: Boscalid Screening Level Usage Analysis (S LUA ).Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

PC Code: 128008

Page 23 of 24 

### 1 2 3 4 5 

### 6 

### 7 8 

### 9 10
11 

### 12 13 14 15 16 17 18 

### 19 20 21 22**2~** 

### 24 25 26 27 28 29 30 31 32 33 34 35 36 37 Date: March 

### 1, 2013 Screening Level Estimates of Agricultural Uses of Boscalid 

### (128008) Sorted Alphabetically Reporting Years: 

### 2004-2011

Pereent 

### Cro J Treated 

### Crop**~** Lbs. A.I. 

### Av_,g. Max.
Almonds 70,000 40 60 Apples 10,000 

### ' 15
,, ,, 25 Apricots 1,000 25 60 

## "
Beans, Green 

### ' 6
, 000 5 

## .. 10 j
Blueberries 

### '· 4

, 000 35 45
Broccoli <500 <2

. 5

...... <2

. 5 Brussels Sprouts • <500 ·• NC NC Cabbage

n 2

, 000 5 15

.,,**~** ,, Can e berries 4,000 45 60



### - Cantaloupes 2,000 ,. 5 IS
Carrots 3 000 1S 

## so '· Cauliflower <500 5 5 CeleJY <500 

### " <2.S 5 · Cherries 20000 :r 4S 70 Cucumbers 2,000 5 IS Dry Beans/Peas 10,000 

### ,,, <2.5 ,, 

## s Garlic ,, <500 5 

# . 10 Grapes ' 60

, 000 30 4S
Hazelnuts I,OOO 5 IS
Lettuce 30,000 25 4S
Nectarines ;. <500 I5 2S
Onions 10,000 20 

### '" 35 Peaches 5 000 20 40
Peanuts 1,000 <1 <2.5
Pears 

### ' 2000 15 30
Peas Green <500 <I <2.5 Peppers 

### ' <500 <2

. S <2.5 :r

Pistachios 10,000 30 40 '· Plums/Prunes I,OOO**~** 5
., , I5 Pluots • <500 NC NC
Potatoes 60000 ,. 20 40 Pumpkins I**~** 2,000 IO 20 Squash I,OOO 5 IS
Strawberries 20,000 55 80
Tomatoes 3,000 5 IS 

### ' Walnuts I,OOO <1 <2.5
Watermelons**·~** IO,OOO 2S 45Boscalid Dietary Exposure and Risk Assessment DP Number: 410743

PC Code: 128008

Page 24 of 24