<PAGE>
        Confidential Treatment has been requested for portions of this
agreement. Those portions have been marked [Redacted].

                                                                    Exhibit 10.9

                      SECOND AMENDMENT TO REVOLVING CREDIT
                             AND TERM LOAN AGREEMENT

         SECOND AMENDMENT (the "Second Amendment") entered into as of November
15, 2002 by and among HI-TECH PHARMACAL CO., INC. (the "Company") and [Redacted]
(the "Guarantor"), each a Delaware corporation, with its principal place of
business at 369 Bayview Avenue, Amityville, New York 11701 and FLEET NATIONAL
BANK, a national banking association, having a place of business located at 300
Broad Hollow Road, Melville, New York 11747 (the "Bank").

         WHEREAS, the Borrower, the Guarantor and the Bank are parties to a
Revolving Credit and Term Loan Agreement dated as of October 23, 2002, as
amended by the First Amendment dated as of November 1, 2002 as same may be
hereafter amended and modified (the "Agreement"); and

         WHEREAS, the Borrower and the Guarantor have requested that the Bank
amend, and the Bank has agreed to amend a provision of the Agreement.

         NOW, THEREFORE, the parties hereto hereby agree as follows:

         1.  All capitalized terms used herein, unless otherwise defined herein,
have the same meanings provided therefor in the Agreement.

         2.  The Agreement is hereby amended as follows:

             (a)   Section 2.6 is amended by deleting such Section and
substituting the following therefor:

             "2.6  Term Loan: Subject to the terms and conditions hereof, the
         Bank agrees to make a term loan (the "Term Loan") to the Company on the
         date of satisfaction of the conditions precedent contained in Section
         4.2 hereof but no later than December 16, 2002 in the principal amount
         of Eight Million and 00/100 ($8,000,000.00) Dollars to partially fund
         the Acquisition. The Term Loan shall bear interest at a rate per annum
         to be elected by the Company upon the making of the Term Loan and
         continued or converted in accordance with the requirements of Section
         2.8 hereof, equal to (y) the Prime Rate in effect from time to time or
         (z) the LIBOR Rate for a one month Interest Period plus 1.75% which, at
         the Company's option, may be swapped into a fixed rate equivalent in
         accordance with the Master Agreement."

             (b)   Section 2.7 is amended by deleting such Section and
substituting the following therefor:

             "2.7  Term Note: The Term Loan shall be evidenced by a promissory
         note of the Company substantially in the form of Exhibit B hereto with
         appropriate insertions (the "Term Note") payable to the order of the
         Bank and dated the date of

<PAGE>

         the Term Loan. The principal amount of the Term Note shall be payable
         in sixty (60) consecutive monthly installments, the first fifty-nine
         (59) of which shall be in an amount equal to $133,333.00 each, and the
         final installment to be in the amount equal to the then unpaid
         principal balance, payable on the first day of each month commencing
         January 1, 2003 until December 1, 2007 when the entire unpaid principal
         balance of the Term Note together with all interest accrued and unpaid
         shall be paid in full. In all cases, interest shall be computed on the
         basis of a 360 day year for actual days elapsed and shall be payable as
         provided in Section 2.9(a) hereof. After any stated or accelerated
         maturity thereof, the Term Note shall bear interest at the Post Default
         Rate."

             (c) Exhibit B is amended by deleting same and substituting the
attached Exhibit B-1 therefor.

             (d) The first paragraph of Section 3.1 of the Schedule is amended
by deleting same and substituting the following:

             "The Company will cause the Guarantor to qualify in New York State
         within ninety (90) days of the date hereof. The Company will cause Rose
         Laboratories, Inc. to be dissolved by April 30, 2003."

         3.  The Borrower and the Guarantor hereby represent and warrant to the
Bank that:

             (a) There are no defenses or offsets to their respective
obligations under the Agreement, the Notes, or the Loan Documents, and if any
such defenses or offsets exist, the same are hereby waived.

             (b) Each and every of the representations and warranties set forth
in the Agreement is true as of the date hereof and with the same effect as
though made on the date hereof, and is hereby incorporated herein in full by
reference as if fully restated herein in its entirety.

             (c) No Default or Event of Default and no event or condition which,
with the giving of notice or lapse of time or both, would constitute such a
Default or Event of Default, now exists or would exist after giving effect
hereto.

         4.  It is expressly understood and agreed that all collateral security
for the Loans and other extensions of credit set forth in the Agreement prior to
the amendment provided for herein is and shall continue to be collateral
security for the Loans and other extensions of credit provided in the Agreement
as herein amended. Without limiting the generality of the foregoing, the
Borrower and the Guarantor hereby absolutely and unconditionally confirm that
each document and instrument executed by them pursuant to the Agreement
continues in full force and effect, is ratified and confirmed and is and shall
continue to be applicable to the Agreement (as herein amended).

                                       -2-

<PAGE>

         5. The amendments set forth herein are limited precisely as written and
shall not be deemed to (a) be a consent to or a waiver of any other term or
condition of the Agreement or any of the documents referred to therein, or (b)
prejudice any right or rights which the Bank may now have or may have in the
future under or in connection with the Agreement or any documents referred to
therein. Whenever the Agreement is referred to in the Agreement or any of the
instruments, agreements or other documents or papers executed and delivered in
connection therewith, it shall be deemed to mean the Agreement as modified by
this Second Amendment.

         6. The Borrower agrees to pay on demand, and the Bank may charge any
deposit or loan account(s) of the Borrower, for all reasonable expenses
(including reasonable attorneys fees) incurred by the Bank in connection with
the negotiation, preparation and administration of the Agreement as amended
hereby.

         7. This Second Amendment is dated as of November 15, 2002 and shall be
effective on the date of execution by the Bank.

         8. This Second Amendment may be executed in counterparts, each of which
shall constitute an original, and each of which taken together shall constitute
one and the same agreement.

                                      -3-

<PAGE>

         IN WITNESS WHEREOF, the parties hereto have duly executed this Second
Amendment the year and date first above written.

                                             HI-TECH PHARMACAL CO., INC.


                                             By: /s/ David Seltzer
                                                 ---------------------------

                                                 David Seltzer
                                                 President

                                             [REDACTED]


                                             By: /s/ David Seltzer
                                                 --------------------------

                                                 David Seltzer
                                                 President

                                             FLEET NATIONAL BANK


                                             By: /s/ Richard B. Martin
                                                ---------------------------

                                                   Richard B. Martin
                                                   Vice President

State of New York, County of Nassau   ,ss:

         On the 22/nd/ day of November, in the year 2002, before me the
undersigned, personally appeared DAVID SELTZER, personally known to me or proved
to me on the basis of satisfactory evidence to be the individual whose name is
subscribed to the within instrument and acknowledged to me that he executed the
same in his capacity, and that by his signature on the instrument, the
individual or the person upon behalf of which the individual acted, executed the
instrument.

                                              /s/ Pamela S. Charles
                                              ---------------------

                                              Notary Public

PAMELA S. CHARLES
Notary Public, State of New York
No. 02CH499454
Qualified in Nassau County Commission Expires July 16, 2006

                                       -4-