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Exhibit 10.1    
  


 
 

MACROPORE BIOSURGERY, INC.
  REGISTRATION RIGHTS AGREEMENT    
  


        THIS REGISTRATION RIGHTS AGREEMENT (this "Agreement") is entered into as of the 13th day of November, 2002, by and
among MacroPore Biosurgery Inc., a Delaware corporation (the "Company"), and the holders of shares of the Company's Common Stock identified on  Schedule A attached hereto (each a "Holder" and
collectively, "Holders"). 



        WHEREAS, Holders previously held shares of StemSource, Inc., a Delaware corporation ("StemSource") and have now acquired shares of
the Company pursuant to the Agreement and Plan of Reorganization dated October 9, 2002 (the "Merger Agreement"), pursuant to which SS Acquisition, Inc., a wholly-owned subsidiary of the
Company, merged with and into StemSource. 


        WHEREAS, in connection with the Merger Agreement and the transactions contemplated therein, the parties desire to enter into this
Agreement in order to grant registration rights to the Holders as set forth below. 



        NOW, THEREFORE, in consideration of the premises and for other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the parties agree hereto as follows: 


SECTION 1. GENERAL.  


        1.1    Definitions.    As used in this Agreement the following terms shall have the following respective meanings: 



        (a)  "Exchange Act" means the Securities Exchange Act of 1934, as amended. 


        (b)  "Holder" means any person owning of record Registrable Securities that have not been sold to the public or any assignee
of record of such Registrable Securities. 


        (c)  "Register," "registered," and "registration" refer to a registration effected by preparing and filing a registration
statement in compliance with the Securities Act, and the declaration or ordering of effectiveness of such registration statement or document. 



        (d)  "Registrable Securities" means (a) the Shares and (b) any Common Stock of the Company issued as (or
issuable upon the conversion or exercise of any warrant, right or other security which is issued as) a dividend or other distribution with respect to, or in exchange for or in replacement of, the
Shares. Notwithstanding the foregoing, Registrable Securities shall not include any securities sold by a person to the public either pursuant to a registration statement or Rule 144 or sold in
a private transaction in which the transferor's rights under Section 2 of this Agreement are not assigned. 


        (e)  "Registrable Securities then outstanding" shall be the number of shares determined by calculating the total number of
shares of the Company's Common Stock that are Registrable Securities and either (a) are then issued and outstanding or (b) are issuable pursuant to then exercisable or convertible
securities. 


        (f)    "Registration Expenses" shall mean all expenses incurred by the Company in complying with Section 2.1 hereof,
including, without limitation, all registration and filing fees, printing expenses, fees and disbursements of counsel for the Company, blue sky fees and expenses and the expense of any special audits
incident to or required by any such registration (but excluding the compensation of regular employees of the Company which shall be paid in any event by the Company). 



        (g)  "SEC" or "Commission" means the Securities and Exchange Commission. 


        (h)  "Securities Act" shall mean the Securities Act of 1933, as amended. 






 




        (i)    "Selling Expenses" shall mean all legal fees and expenses of any counsel to the selling stockholders, underwriting
discounts and selling commissions applicable to the sale. 


        (j)    "Shares" shall mean the Company's Common Stock issued pursuant to the certain Merger Agreement and held by the Holder or
its permitted assigns. 


        (k)  "Special Registration Statement" shall mean (i) a registration statement relating to any employee benefit plan or
(ii) with respect to any corporate reorganization or transaction under Rule 145 of the Securities Act, including any registration statements related to the resale of securities issued in
such a transaction or (iii) a registration related to stock issued upon conversion of debt securities. 




SECTION 2. REGISTRATION.  


        2.1    Piggyback Registrations.    The Company shall notify all Holders of Registrable Securities in writing at least
fifteen (15) days prior to the filing of any registration statement under the Securities Act for purposes of a public offering of securities of the Company (including, but not limited to,
registration statements relating to secondary offerings of securities of the Company, but excluding Special Registration Statements) in which Christopher Calhoun, Ralph Holmes or Stefan Lemperle (the
"Founders") are to participate as selling stockholders, and will afford each such Holder an opportunity to include in such registration statement all or part of such Registrable Securities held by
such Holder. Each Holder desiring to include in any such registration statement all or any part of the Registrable Securities held by it shall, within fifteen (15) days after the
above-described notice from the Company, so notify the Company in writing. Such notice shall state the intended method of disposition of the Registrable Securities by such Holder. If a Holder decides
not to include all of its Registrable Securities in any registration statement thereafter filed by the Company, such Holder shall nevertheless continue to have the right to include any Registrable
Securities in any subsequent registration statement or registration statements as may be filed by the Company with respect to offerings of its securities, all upon the terms and conditions set forth
herein. 



        (a)    Underwriting.    If the registration statement under which the Company gives notice under this
Section 2.1 is for an underwritten offering, the Company shall so advise the Holders of Registrable Securities. In such event, the right of any such Holder to be included in a registration
pursuant to this Section 2.1 shall be conditioned upon such Holder's participation in such underwriting and the inclusion of such Holder's Registrable Securities in the underwriting to the
extent provided herein. All Holders proposing to distribute their Registrable Securities through such underwriting shall enter into an underwriting agreement in customary form with the underwriter or
underwriters selected for such underwriting by the Company. Notwithstanding any other provision of this Agreement, if the underwriter determines in good faith that marketing factors require a
limitation of the number of shares to be underwritten, the number of shares that may be included in the underwriting shall be allocated, first, to the Company; and second, to all other selling
stockholders of the Company (including a Holder) on a pro rata basis. Without limiting the foregoing, all Holders may be excluded entirely from such
offering if none of the Founders participate as selling stockholders in such offering. If any Holder disapproves of the terms of any such underwriting, such Holder may elect to withdraw therefrom by
written notice to the Company and the underwriter, delivered at least ten (10) business days prior to the effective date of the registration statement. Any Registrable Securities excluded or
withdrawn from such underwriting shall be excluded and withdrawn from the registration. For any Holder which is a partnership or corporation, the partners, retired partners and stockholders of such
Holder, or the estates and family members of any such partners and retired partners and any trusts for the benefit of any of the foregoing person shall be deemed to be a single "Holder," and any  pro rata reduction with respect to such "Holder" shall be based upon the aggregate amount of shares carrying registration rights owned by all entities
and individuals included in such "Holder," as 



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defined in this sentence divided by the total number of shares held by all stockholders proposed to be included as selling stockholders in the registration statement. 


        (b)    Right to Terminate Registration.    The Company shall have the right to terminate or withdraw any registration
initiated by it under this Section 2.1 prior to the effectiveness of such registration whether or not any Holder has elected to include securities in such registration. The Registration
Expenses of such withdrawn registration shall be borne by the Company in accordance with Section 2.2 hereof. 




        2.2    Expenses of Registration.    Except as specifically provided herein, all Registration Expenses incurred in
connection with any registration, qualification or compliance pursuant to Section 2.1 herein shall be borne by the Company. All Selling Expenses incurred in connection with any registrations
hereunder, shall be borne by the holders of the securities so registered pro rata on the basis of the number of shares so registered. 


        2.3    Obligations of the Company.    Whenever required to effect the registration of any Registrable Securities, the
Company shall, as expeditiously as reasonably possible: 



        (a)  Prepare and file with the SEC a registration statement with respect to such Registrable Securities and use all reasonable
efforts to cause such registration statement to become effective and remain
effective for a period ninety (90) days or until the Holder or Holders have completed the distribution related thereto, whichever first occurs. 


        (b)  Prepare and file with the SEC such amendments and supplements to such registration statement and the prospectus used in
connection with such registration statement as may be necessary to comply with the provisions of the Securities Act with respect to the disposition of all securities covered by such registration
statement for the period set forth in paragraph (a) above. 


        (c)  Furnish to the Holders such number of copies of a prospectus, including a preliminary prospectus, in conformity with the
requirements of the Securities Act, and such other documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them. 


        (d)  Use its reasonable efforts to register and qualify the securities covered by such registration statement under such other
securities or blue sky laws of such jurisdictions as shall be reasonably requested by the Holders; provided that the Company shall not be required in
connection therewith or as a condition thereto to qualify to do business or to file a general consent to service of process in any such states or jurisdictions. 


        (e)  In the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement,
in usual and customary form, with the managing underwriter(s) of such offering. Each Holder participating in such underwriting shall also enter into and perform its obligations under such an
agreement. 


        (f)    Notify each Holder of Registrable Securities covered by such registration statement at any time when a prospectus
relating thereto is required to be delivered under the Securities Act of the happening of any event as a result of which the prospectus included in such registration statement, as then in effect,
includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the
circumstances then existing. 


        (g)  Use its reasonable efforts to furnish, on the date that such Registrable Securities are delivered to the underwriters for
sale, if such securities are being sold through underwriters, (i) an opinion, dated as of such date, of the counsel representing the Company for the purposes of such registration, in form and
substance as is customarily given to underwriters in an underwritten public offering, addressed to the underwriters, if any, and (ii) a letter, dated as of such date, from 



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the independent certified public accountants of the Company, in form and substance as is customarily given by independent certified public accountants to underwriters in an underwritten public
offering addressed to the underwriters. 




        2.4    Termination of Registration Rights.    All registration rights granted under this Section 2 shall
terminate and be of no further force and effect four (4) years from the date hereof. 


        2.5    Delay of Registration; Furnishing Information.    



        (a)  No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any such registration as
the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 


        (b)  It shall be a condition precedent to the obligations of the Company to take any action pursuant to Section 2.1
that the selling Holders shall furnish to the Company such information regarding themselves, the Registrable Securities held by them and the intended method of disposition of such securities as shall
be required to effect the registration of their Registrable Securities. 




        2.6    Indemnification.    In the event any Registrable Securities are included in a registration statement under
Section 2.1: 



        (a)  To the extent permitted by law, the Company will indemnify and hold harmless each Holder, the partners, officers and
directors of each Holder, any underwriter (as defined in the Securities Act) for such Holder and each person, if any, who controls such Holder or underwriter within the meaning of the Securities Act
or the Exchange Act, against any losses, claims, damages, or liabilities (joint or several) to which they may become subject under the Securities Act, the Exchange Act or other federal or state law,
insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon any of the following statements, omissions or violations (collectively a
"Violation") by the Company: (i) any untrue statement or alleged untrue statement of a material fact contained in such registration statement,
including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto, (ii) the omission or alleged omission to state therein a material fact
required to be stated therein, or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation by the Company of the Securities Act, the Exchange Act,
any state securities law or any rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities law in connection with the offering covered by such registration
statement; and the Company will pay as incurred to each such Holder, partner, officer, director, underwriter or controlling person any legal or other expenses reasonably incurred by them in connection
with investigating or defending any such loss, claim, damage, liability or action; provided however, that the indemnity agreement contained in this
Section 2.6(a) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the Company, which
consent shall not be unreasonably withheld, nor shall the Company be liable in any such case for any such loss, claim, damage, liability or action to the extent that it arises out of or is based upon
a Violation which occurs in reliance upon and in conformity with written information furnished expressly for use in connection with such registration by such Holder, partner, officer, director,
underwriter or controlling person of such Holder. 


        (b)  To the extent permitted by law, each Holder will, if Registrable Securities held by such Holder are included in the
securities as to which such registration, qualifications or compliance is being effected, indemnify and hold harmless the Company, each of its directors, its officers and each person, if any, who
controls the Company within the meaning of the Securities Act, any underwriter and any other Holder selling securities under such registration statement or any of such other Holder's partners,
directors or officers or any person who controls such Holder, against 



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any losses, claims, damages or liabilities (joint or several) to which the Company or any such director, officer, controlling person, underwriter or other such Holder, or partner, director, officer
or controlling person of such other Holder may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages or liabilities (or
actions in respect thereto) arise out of or are based upon any Violation, in each case to the extent (and only to the extent) that such Violation occurs in reliance upon and in conformity with written
information furnished by such Holder under an instrument duly executed by such Holder and stated to be specifically for use in connection with such registration; and each such Holder will pay as
incurred any legal or other expenses reasonably incurred by the Company or any such director, officer, controlling person, underwriter or other Holder, or partner, officer, director or controlling
person of such other Holder in connection with investigating or defending any such loss, claim, damage, liability or action; provided, however, that the
indemnity agreement contained in this Section 2.6(b) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected without
the consent of the Holder, which consent shall not be unreasonably withheld; provided further, that in no event shall any indemnity under this
Section 2.6 exceed the gross proceeds from the offering received by such Holder except in the case of willful fraud of such Holder. 


        (c)  Promptly after receipt by an indemnified party under this Section 2.6 of notice of the commencement of any action
(including any governmental action), such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Section 2.6, deliver to the indemnifying
party a written notice of the commencement thereof and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly with any other
indemnifying party similarly noticed, to assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an
indemnified party shall have the right to retain its own counsel, with the reasonable fees and expenses to be paid by the indemnifying party, if representation of such indemnified party by the counsel
retained by the indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any other party represented by such counsel in such
proceeding. The failure to deliver written notice to the indemnifying party within a reasonable time of the commencement of any such action, if materially prejudicial to its ability to defend such
action, shall relieve such indemnifying party of any liability to the indemnified party under this Section 2.6, but the omission so to deliver written notice to the indemnifying party will not
relieve it of any liability that it may have to any indemnified party otherwise than under this Section 2.6. 


        (d)  If the indemnification provided for in this Section 2.6 is held by a court of competent jurisdiction to be
unavailable to an indemnified party with respect to any losses, claims, damages or liabilities referred to herein, the indemnifying party, in lieu of indemnifying such indemnified party hereunder,
shall to the extent permitted by applicable law contribute to the amount paid or payable by such indemnified party as a result of such loss, claim, damage or liability in such proportion as is
appropriate to reflect the relative fault of the indemnifying party on the one hand and of the indemnified party on the other in
connection with the Violation(s) that resulted in such loss, claim, damage or liability, as well as any other relevant equitable considerations. The relative fault of the indemnifying party and of the
indemnified party shall be determined by a court of law by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission to state a material fact
relates to information supplied by the indemnifying party or by the indemnified party and the parties' relative intent, knowledge, access to information and opportunity to correct or prevent such
statement or omission; provided, that in no event shall any contribution by a Holder hereunder exceed the net proceeds from the offering received by
such Holder except in the case of willful fraud of such Holder. 



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        (e)  The obligations of the Company and Holders under this Section 2.6 shall survive completion of any offering of
Registrable Securities in a registration statement and the termination of this Agreement. No indemnifying party, in the defense of any such claim or litigation, shall, except with the consent of each
indemnified party, consent to entry of any judgment or enter into any settlement which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such indemnified
party of a release from all liability in respect to such claim or litigation. 




        Notwithstanding
the foregoing, to the extent the indemnification provisions contained in the underwriting agreement entered into in connection with the underwritten public offering are
in conflict with the foregoing provisions, the provisions in the underwriting agreement shall control. 



        2.7    Limitation on Subsequent Registration Rights.    After the date of this Agreement, the Company shall not,
without the prior written consent of the Holders of at least a majority of the Registrable Securities then outstanding, enter into any agreement with any holder or prospective holder of any securities
of the Company that would grant such holder rights senior to those granted to the Holders hereunder with respect to the allocation of shares in an underwriting agreement. 



SECTION 3. MISCELLANEOUS.  


        3.1    Governing Law.    This Agreement shall be governed by and construed under the laws of the State of California
as applied to agreements among California residents entered into and to be performed entirely within California. 


        3.2    Survival.    The representations, warranties, covenants, and agreements made herein shall survive any
investigation made by any Holder or the Company and the closing of the transactions contemplated hereby. All statements as to factual matters contained in any certificate or other instrument delivered
by or on behalf of the Company pursuant hereto in connection with the transactions contemplated hereby shall be deemed to be representations and warranties by the Company hereunder solely as of the
date of such certificate or instrument. 


        3.3    Successors and Assigns.    Except as otherwise expressly provided herein, the provisions hereof shall inure to
the benefit of, and be binding upon, the successors, assigns, heirs, executors, and administrators of the parties hereto and shall inure to the benefit of and be enforceable by each person who shall
be a holder of Registrable Securities from time to time; provided, however, that prior to the receipt by the Company of adequate written notice of the
transfer of any Registrable Securities specifying the full name and address of the transferee, the Company may deem and treat the person listed as the holder of such shares in its records as the
absolute owner and holder of such shares for all purposes, including the payment of dividends or any redemption price. 


        3.4    Entire Agreement.    This Agreement, the Merger Agreement and the other documents delivered pursuant thereto
constitute the full and entire understanding and agreement between the parties with regard to the subjects hereof and no party shall be liable or bound to any other in any manner by any
representations, warranties, covenants and agreements except as specifically set forth herein and therein. 



        3.5    Severability.    In the event one or more of the provisions of this Agreement should, for any reason, be held
to be invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other provisions of this Agreement, and this Agreement shall be construed
as if such invalid, illegal or unenforceable provision had never been contained herein. 


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        3.6    Amendment and Waiver.    



        (a)  Except as otherwise expressly provided, this Agreement may be amended or modified only upon the written consent of the
Company and the holders of at least a majority of the Registrable Securities. 


        (b)  Except as otherwise expressly provided, the obligations of the Company and the rights of the Holders under this Agreement
may be waived only with the written consent of the holders of at least a majority of the Registrable Securities. 


        (c)  For the purposes of determining the number of Holders entitled to vote or exercise any rights hereunder, the Company
shall be entitled to rely solely on the list of record holders of its stock as maintained by or on behalf of the Company. 




        3.7    Delays or Omissions.    It is agreed that no delay or omission to exercise any right, power, or remedy accruing
to any Holder, upon any breach, default or noncompliance of the Company under this Agreement shall impair any such right, power, or remedy, nor shall it be construed to be a waiver of any such breach,
default or noncompliance, or any acquiescence therein, or of any similar breach, default or noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent, or approval of
any kind or character on any Holder's part of any breach, default or noncompliance under the Agreement or any waiver on such Holder's part of any provisions or conditions of this Agreement must be in
writing and shall be effective only to the extent specifically set forth in such writing. All remedies, either under this Agreement, by law, or otherwise, shall be cumulative and not alternative. 



        3.8    Notices.    All notices required or permitted hereunder shall be in writing and shall be deemed effectively
given: (a) upon personal delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the recipient; if not, then
on the next business day, (c) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one (1) day after
deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. All communications shall be sent to the party to be notified at the address
as set forth on the signature pages hereof or at such other address as such party may designate by ten (10) days advance written notice to the other parties hereto. 


        3.9    Attorneys' Fees.    In the event that any suit or action is instituted to enforce any provision in this
Agreement, the prevailing party in such dispute shall be entitled to recover from the losing party all fees, costs and expenses of enforcing any right of such prevailing party under or with respect to
this Agreement, including without limitation, such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation, all fees, costs and expenses of appeals. 



        3.10    Titles and Subtitles.    The titles of the sections and subsections of this Agreement are for convenience of
reference only and are not to be considered in construing this Agreement. 


        3.11    Counterparts.    This Agreement may be executed in any number of counterparts, each of which shall be an
original, but all of which together shall constitute one instrument. 


[THIS
SPACE INTENTIONALLY LEFT BLANK] 


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        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	COMPANY:	 	HOLDER:
	

MACROPORE BIOSURGERY, INC.	
 	

        

	

By:	
 	

/s/  CHRISTOPHER J. CALHOUN      
	
 	

By:	
 	

        

	

Title:	
 	

President and Chief Financial Officer
	
 	

Title:	
 	

        

	

Address:	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

MARC HEDRICK
	

 	
 	

By:	
 	

/s/  MARC HEDRICK      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

TERRY BUTLER
	

 	
 	

By:	
 	

/s/  TERRY BUTLER      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

WILLIAM FUTRELL
	

 	
 	

By:	
 	

        

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

RAMON LLULL
	

 	
 	

By:	
 	

/s/  RAMON LLULL      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

MIKE LONGAKER
	

 	
 	

By:	
 	

        

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

BRIAN MATTHEWS
	

 	
 	

By:	
 	

/s/  BRIAN MATTHEWS      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

TERRY CROSS TRUST
	

 	
 	

By:	
 	

/s/  TERRY CROSS      

	

 	
 	

Title:	
 	

Trustee

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

J.M. PAYNE III DDS
	

 	
 	

By:	
 	

/s/  J.M. PAYNE III      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

AT VENTURE
	

 	
 	

By:	
 	

        

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

JORG VON HACHT
	

 	
 	

By:	
 	

/s/  JORG VON HACHT      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

CHRISTOF SCHOERNIG
	

 	
 	

By:	
 	

/s/  CHRISTOF SCHOERNIG      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

MARTIN KORBMACHER
	

 	
 	

By:	
 	

/s/  MARTIN KORBMACHER      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

PETER CONZATTI
	

 	
 	

By:	
 	

/s/  PETER CONZATTI      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

COLO LLC
	

 	
 	

By:	
 	

/s/  NORM HIGO      

	

 	
 	

Title:	
 	

Managing Director

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

JAMES T. HEDRICK
	

 	
 	

By:	
 	

/s/  JAMES T. HEDRICK      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

DAVID FUNG
	

 	
 	

By:	
 	

/s/  DAVID FUNG      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

DANIEL E. BUTLER TRUST
	

 	
 	

By:	
 	

/s/  DANIEL E. BUTLER      

	

 	
 	

Title:	
 	

Trustee

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

THOMAS MITTS
	

 	
 	

By:	
 	

        

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

RON HENRIKSEN
	

 	
 	

By:	
 	

/s/  RONALD D. HENRIKSEN      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

BOB KRAMER
	

 	
 	

By:	
 	

/s/  BOB KRAMER      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

PETER FODOR
	

 	
 	

By:	
 	

/s/  PETER FODOR      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

JOHN FRASER
	

 	
 	

By:	
 	

        

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 






        IN WITNESS WHEREOF, the parties hereto have executed this REGISTRATION RIGHTS AGREEMENT as
of the date set forth in the first paragraph hereof. 



	 	 	HOLDER:
	

 	
 	

ELIZABETH SCARBOROUGH
	

 	
 	

By:	
 	

/s/  ELIZABETH SCARBOROUGH      

	

 	
 	

Title:	
 	

        

	

 	
 	

Address:






[Signature
Page to Registration Statement] 







 
 

SCHEDULE A    
  


Marc
Hedrick

Terry Butler

William Futrell

Ramon Llull

Mike Longaker

Brian Matthews

Terry Cross Trust

J.M. Payne III DDS

AT Venture

Jorg Van Hacht

Christof Schoernig

Martin Korbmacher

Peter Conzatti

Norm Higo

John Hedrick

David Fung

Dan and Mary Ann Butler

Thomas Mitts

Ron Henriksen

Bob Kramer

Peter Fodor

John Fraser

Elizabeth Scarborough 


[Signature
Page to Registration Rights Agreement] 








	

SECTION 1.GENERAL	
 	

1
	 	

1.1	
 	

Definitions	
 	

1
	

SECTION 2.REGISTRATION	
 	

2
	 	

2.1	
 	

Piggyback Registrations	
 	

2
	 	

2.2	
 	

Expenses of Registration	
 	

3
	 	

2.3	
 	

Obligations of the Company	
 	

3
	 	

2.4	
 	

Termination of Registration Rights	
 	

4
	 	

2.5	
 	

Delay of Registration; Furnishing Information	
 	

4
	 	

2.6	
 	

Indemnification	
 	

4
	 	

2.7	
 	

Limitation on Subsequent Registration Rights	
 	

6
	

SECTION 3.MISCELLANEOUS	
 	

6
	 	

3.1	
 	

Governing Law	
 	

6
	 	

3.2	
 	

Survival	
 	

6
	 	

3.3	
 	

Successors and Assigns	
 	

6
	 	

3.4	
 	

Entire Agreement	
 	

6
	 	

3.5	
 	

Severability	
 	

6
	 	

3.6	
 	

Amendment and Waiver	
 	

7
	 	

3.7	
 	

Delays or Omissions	
 	

7
	 	

3.8	
 	

Notices	
 	

7
	 	

3.9	
 	

Attorneys' Fees	
 	

7
	 	

3.10	
 	

Titles and Subtitles	
 	

7
	 	

3.11	
 	

Counterparts	
 	

7











QuickLinks



Exhibit 10.1


MACROPORE BIOSURGERY, INC. REGISTRATION RIGHTS AGREEMENT



SCHEDULE A