1

Tables of Alternatives for End-Uses Considered in the Notice of 

Proposed Rule Making, 

Protection of Stratospheric Ozone: Proposed New Listings of 

Substitutes; Changes of Listing Status; and Reinterpretation of 

Unacceptability for Closed Cell Foam Products under the Significant 

New Alternatives Policy Program; and Revision of Clean Air Act Section 

608’s Venting Prohibition for Propane

March 2016

U.S. Environmental Protection Agency

Stratospheric Protection Division

Office of Atmospheric Programs Office of Air and Radiation
2

1 SUBSTITUTES FOR NEWLY-MANUFACTURED HEAVY-DUTY MOTOR VEHICLE AIR CONDITIONING 

SYSTEMS

The references to environmental and health properties of substitutes acceptable, subject to use conditions, are summarized in the table below.

(Substitutes previously listed as unacceptable are not included here.)

Table 1. Environmental and Health Properties of Non-Ozone Depleting Refrigerants in Heavy-Duty Motor 

Vehicle Air Conditioning Systems1

Substitute Name Further Identification Information for 

Substitute

Reference to the Applicable SNAP Rule, Notice, Or 

Acceptability Determination for the ODP, GWP, VOC 

Status, Flammability, and Exposure Limit for Each Listed 

Substitute

Carbon Dioxide

R-744;

CO2; 

CAS # 124-38-9

Refer to Initial SNAP Rule, SNAP Rule 14, SNAP Notice 10,

and SNAP Notice 25.

Evaporative 

Cooling N/A Refer to Initial SNAP Rule.

HFC-152a 1,1-difluoroethane; 

CAS # 75-34-3

Refer to SNAP Rule 14 and SNAP Notice 25.

Ikon A 

Ikon 12; 

Blend Zeta; 

Composition is claimed as confidential 

business information (CBI)

Refer to SNAP Notice 13.2

R-426A

RS-24 (new formulation);

HFC-125/HFC-134a/HC-600/HC-601a 

(5.1/93/ 1.3/0.6)

Refer to SNAP Notice 21 and SNAP Notice 25.

SP34E Composition is claimed as CBI Refer to SNAP Notice 14 and SNAP Notice 25.

1HCFC-22 and several blends containing HCFCs are also listed as acceptable but their use is severely restricted by the phasedown in HCFC 

production and consumption. 2Refer to IPCC Fourth Assessment Report for GWP value of components.
3

2 FOAM BLOWING AGENTS

The references to environmental and health properties of acceptable substitutes, and substitutes whose status would change under the final 

rule for foam blowing agents are summarized in the tables below. The end-uses included in the proposed rule in the foam blowing agent sector 

are the following: Rigid Polyurethane (PU): Spray, Flexible PU, Integral Skin PU, and Polyolefin. (Substitutes listed as unacceptable in previous 

rules, e.g., HCFCs, are not included here.)

Table 2. Environmental and Health Properties of Foam Blowing Agents

Substitute Name Further Identification Information for 

Substitute

Reference to the Applicable SNAP Rule, Notice, Or 

Acceptability Determination for the ODP, GWP, VOC 

Status, Flammability, and Exposure Limit for Each 

Listed Substitute

AB Technology

Reaction of formic acid with isocyanate to 

produce carbon monoxide and 

water/isocyanate reaction to generate 

carbon dioxide for the expansion of foam

Refer to Initial SNAP Rule.

Acetone 2-propanone;

CAS # 67-64-1

Refer to SNAP Notice 8 and SNAP Notice 25.

Commercial 

blends of HFC–

365mfc and HFC–

227ea containing 

7% to 13% HFC–

227ea and the 

remainder HFC–

365mfc

HFC-365mfc is also known as 1,1,1,3,3-

pentafluorobutane,

CAS # 405-58-6; HFC-227ea is also known 

as 1,1,1,2,3,3,3-heptafluoropropane;

CAS # 431-89-0. Commercial blends 

include 7% HFC-227ea/93% HFC-365mfc 

and 13% HFC-227ea/87% HFC-365mfc. 

Also see row in this table on HFC-365mfc

for more information.

Refer to SNAP Acceptability Determination 28.

Blends of HFC365mfc & HFC245fa, >5% HFC245fa

See other rows in this table for more 

information on the component blowing 

agents

Refer to SNAP Notice 24 and SNAP Notice 25.
4

Substitute Name Further Identification Information for 

Substitute

Reference to the Applicable SNAP Rule, Notice, Or 

Acceptability Determination for the ODP, GWP, VOC 

Status, Flammability, and Exposure Limit for Each 

Listed Substitute

C3-C6 Saturated 

Light 

Hydrocarbons 

Examples: propane, butane, isobutane, npentane, cyclopentane, hexane, 

cyclohexane

Refer to SNAP Notice 1, SNAP Notice 12, and SNAP 

Notice 25.

Carbon Dioxide CO2;

CAS # 124-38-9

Refer to Initial SNAP Rule, SNAP Rule 14, SNAP Notice 

10 and SNAP Notice 25.

EcomateTM methyl formate

Refer to SNAP Notice 18, SNAP Notice 21, and SNAP 

Notice 25.

Electroset 

Technology

A proprietary process that makes organic 

resins electrically semiconductive

Refer to SNAP Notice 1 and SNAP Notice 25.

Exxsol Blowing 

Agents

Blend containing light saturated 

hydrocarbons with 5 carbons

Refer to SNAP Notice 11 and SNAP Notice 25.

HFO–1336mzz(Z)

Formacel® 1100;

(Z)-1,1,1,4,4,4-hexafluorobut-2-ene;

CAS # 692-49-9

Refer to SNAP Acceptability Determination 29 and 

SNAP Acceptability Determination 30.

Formacel® TI HFC Blend; Composition is claimed as CBI Refer to SNAP Notice 24 and SNAP Notice 25.
5

Substitute Name Further Identification Information for 

Substitute

Reference to the Applicable SNAP Rule, Notice, Or 

Acceptability Determination for the ODP, GWP, VOC 

Status, Flammability, and Exposure Limit for Each 

Listed Substitute

Formic Acid

Methanoic acid; 

First listed as Proprietary Blowing Agent 1, 

or PBA 1;

CAS #64-18-6

Refer to SNAP Notice 5, SNAP Notice 8, and SNAP 

Notice 25.

HFC-134a 1,1,1,2-tetrafluoroethane;

CAS # 811-97-2

Refer to Initial SNAP Rule, SNAP Notice 10, and SNAP 

Notice 25.

HFC-143a 1,1,1-trifluoroethane;

CAS # 420-46-2

Refer to Initial SNAP Rule and SNAP Notice 1.1

HFC-152a 1,2-difluoroethane; CAS #75-37-6

Refer to Initial SNAP Rule, SNAP Notice 10, and SNAP 

Notice 25.

HFC-152a/ 

Saturated Light 

Hydrocarbon 

Blends

See other rows in this table for more 

information on the component blowing 

agents

Refer to SNAP Notice 1, SNAP Notice 10, SNAP Notice 

12, and SNAP Notice 25.

HFC-245fa 1,1,1,3,3-pentafluoroethane;

CAS # 460-73-1

Refer to SNAP Notice 11, SNAP Notice 18, and SNAP 

Notice 25.

HFC-365mfc 1,1,1,3,3-pentafluorobutane;

CAS # 405-58-6

Refer to SNAP Notice 24 and SNAP Notice 25.
6

Substitute Name Further Identification Information for 

Substitute

Reference to the Applicable SNAP Rule, Notice, Or 

Acceptability Determination for the ODP, GWP, VOC 

Status, Flammability, and Exposure Limit for Each 

Listed Substitute

HFO-1234ze(E) trans-1,3,3,3-tetrafluoroprop-1-ene;

CAS # -29118-24-9

Refer to SNAP Notice 24 and SNAP Notice 25.

Methyl Formate

Formic acid, methylester ; 

methyl methanoate;

CAS # 107-31-3

Refer to SNAP Notice 14 and SNAP Notice 25.

Methylal Dimethoxymethane;

CAS # 109-87-5

Refer to SNAP Acceptability Determination 29.

Methylene 

Chloride

Dichloromethane; 

CAS # 75-09-2

Refer to Initial SNAP Rule and SNAP Notice 1.1

Trans-1-chloro3,3,3-trifluoroprop-1-eneSolsticeTM LBA; 

Solstice 1233zd(E); 

CAS # 102687-65-0

Refer to SNAP Acceptability Determination 27 and 

SNAP Acceptability Determination 29

TranscendTM

Technologies Composition is claimed as CBI Refer to SNAP Notice 20 and SNAP Notice 25.
7

Substitute Name Further Identification Information for 

Substitute

Reference to the Applicable SNAP Rule, Notice, Or 

Acceptability Determination for the ODP, GWP, VOC 

Status, Flammability, and Exposure Limit for Each 

Listed Substitute

Water H2O;

CAS # 7732-18-5

Refer to SNAP Notice 10 and SNAP Notice 25.

1Refer to IPCC Fourth Assessment Report for GWP value.
8

3 RETAIL FOOD REFRIGERATION—FOOD PROCESSING AND DISPENSING EQUIPMENT

The references to environmental and health properties of acceptable substitutes, substitutes acceptable, subject to use conditions, and 

substitutes whose status would change under the final rule for new retail food refrigeration--food processing and dispensing equipment are 

summarized in the table below. (Substitutes previously listed as unacceptable are not included here.)

 Table 3. Environmental and Health Properties of Refrigerants in Retail Food Refrigeration--Food Processing and 

 Dispensing Equipment1

Substitute Name Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

Carbon Dioxide

R-744; 

CO2;

CAS # 124-38-9

Refer to SNAP Rule 14, Notice 24, and SNAP Notice 25.

FOR12A Composition is claimed as CBI Refer to SNAP Notice 14. 

FOR12B Composition is claimed as CBI Refer to SNAP Notice 14. 

HFC-134a

HFC-134a;

1,1,1,2-tetrafluoroethane; 

CAS # 811-97-2

Refer to Initial SNAP Rule, SNAP Notice 10, and SNAP Notice 25.

ICOR AT-22 HFC-125/HC-290/HFC-134a/ HC600a; (55/1/42.5/ 1.5)

Refer to SNAP Notice 20 and SNAP Notice 25.

Ikon A

Ikon 12;

Blend Zeta; 

Composition is claimed as CBI

Refer to SNAP Notice 13.2
9

Substitute Name Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

Ikon B Composition is claimed as CBI Refer to SNAP Notice 13. 

KDD6 Composition is claimed as CBI Refer to SNAP Notice 23.

R-404A SUVA HP62; HFC-125/HFC143a/HFC-134a; (44/52/ 4)

Refer to Initial SNAP Rule, SNAP Notice 17, and SNAP Notice 25.

2

R-407A

Klea 60; 

Klea 407A;

HFC-32/HFC-125/HFC-134a 

(20/40/40);

Refer to SNAP Notice 1, SNAP Notice 23, and SNAP Notice 25.

R-407B

Klea 61;

HFC-32/HFC-125/HFC-134a; 

(10/70/20)

Refer to SNAP Notice 1 and SNAP Notice 25.

R-407C

Suva 407C; 

Klea 407C;

HFC-32/HFC-125/HFC-134a;

(23/25/52)

Refer to SNAP Notice 4, SNAP 17, and SNAP Notice 18.2
10

Substitute Name Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

R-407F

Genetron Performax LT;

HFC-32/HFC-125/HFC-134a 

(30/30/40)

Refer to SNAP Acceptability Determination 26.

R-410A

AZ-20; 

Suva 9100; 

Puron;

HFC-32/HFC-125; (50/50)

Refer to SNAP Notice 4 and SNAP Notice 17.2

R-410B HFC-32/HFC-125; (45/55) Refer to SNAP Notice 4 and SNAP Notice 25.

R-417A

ISCEON-59; 

NU-22 (new composition);

HFC-125/HFC-134a/HC-600;

(46.6/50/3.4)

Refer to SNAP Notice 11 and SNAP Notice 25.

R-417C ICOR; Hot Shot 2; HFC-125/HFC134a/HC-600 (19.5/78.8/1.7)

Refer to SNAP Acceptability Determination 26.

R-421A Choice R-421A;

HFC-125/HFC-134a; (58/ 42)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-422A

ISCEON 79;

HFC-125/HFC-134a/HC-600a;

(85.1/11.5/3.4)

Refer to SNAP Notice 19.2
11

Substitute Name Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

R-422B

ICOR XAC1; ICOR NU-22B; 

HFC-125/HFC-134a/HC-600a;

(55/42/3)

Refer to SNAP Notice 20 and SNAP Notice 25.

R-422C

ICOR XLT1; One Shot; 

HFC-125/HFC-134a/HC-600a;

(82/15/3)

Refer to SNAP Notice 20 and SNAP Notice 25.

R-422D

ISCEON MO29;

HFC-125/HFC-134a/HC-600a;

(65.1/31.5/3.4)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-424A

RS-44 (new formulation);

HFC-125/HFC-134a/HC-600a/HC600/HC-601a;

(50.5/47/0.9/1/0.6)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-426A

RS-24 (new formulation); 

HFC-125/HFC-134a/HC-600/HC601a; (5.1/93/ 1.3/0.6)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-427A

Forane 427A; HFC-32/HFC125/HFC-143a/HFC-134a 

(15/25/10/50)

Refer to SNAP Notice 23 and SNAP Notice 25.

R-437A

ISCEON MO49 PlusTM; HFC125/HFC-134a/HC-600/HC-601 

(19.5/78.5/ 1.4/0.6)

Refer to SNAP Notice 25.
12

Substitute Name Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

R-438A

KDD5; ISCEON MO99; HFC32/HFC-125/HFC-134a/HC600/HC-601a;

(8.5/45/44.2/1.7/0.6)

Refer to SNAP Notice 24 and SNAP Notice 25.

R-441A

HCR-188C;

HC-170/HC-290/HC-600a/HC600; (3.1/54.8/ 6/36.1)

Refer to SNAP Rule 17.

R-448A

Solstice® N-40; HFC-32/HFC-125/

HFO-1234yf/HFC-134a/HFO1234ze(E); (26/26/20/21/7)Refer to SNAP Acceptability Determination 30.

R-449A

Opteon® XP 40; HFC-32/HFC125/HFO-1234yf/HFC-134a; 

(24.3/24.7/25.3/25.7)

Refer to SNAP Acceptability Determination 30.

R-450A

Solstice® N–13; 

HFC-134a/HFO-1234ze(E);

(42/58)

Refer to SNAP Acceptability Determination 29.

R-507A HFC-125/HFC-143a; (50/ 50)

Refer to Initial SNAP Rule, SNAP Notice 5, SNAP Notice 17, and SNAP

Acceptability Determination 26.

R-513A Opteon® XP 10; HFC-134a/HFO1234yf (44/56) Refer to SNAP Acceptability Determination 30.

R-717 Ammonia; NH3;

CAS # 7664-41-7

Refer to Initial SNAP Rule, SNAP Notice 5, and SNAP Notice 25.
13

Substitute Name Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

RS-24 (2002 

formulation) Composition is claimed as CBI Refer to SNAP Notice 17 and SNAP Notice 25.

RS-44 (2003 

formulation) Composition is claimed as CBI Refer to SNAP Notice 18 and SNAP Notice 25.

SP34E Composition is claimed as CBI Refer to SNAP Notice 14, SNAP Notice 15, and SNAP Notice 25.

THR-02 Composition is claimed as CBI Refer to SNAP Notice 11.

THR-03 Composition is claimed as CBI Refer to SNAP Notice 11.

1 HCFC-22 and several blends containing HCFCs are also listed as acceptable but their use is severely restricted by the phasedown in HCFC production and 

consumption.

 2Refer to IPCC Fourth Assessment Report for GWP value.
14

4 RESIDENTIAL AND LIGHT COMMERCIAL AIR CONDITIONING AND HEAT PUMPS

The references to environmental and health properties of acceptable substitutes and substitutes acceptable, subject to use conditions, for new 

or retrofitted residential and light commercial air conditioning and heat pumps are summarized in the table below. (Substitutes previously listed 

as unacceptable are not included here.)

 Table 4. Environmental and Health Properties of Refrigerants in Household and Light Commercial Air Conditioning

Substitute Name

Further Identification 

Information for 

Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability Determination 

for the ODP, GWP, VOC Status, Flammability, and Exposure Limit for Each Listed 

Substitute

Ammonia 

Absorption R-717 Refer to SNAP Notice 5 and SNAP Notice 25.

Desiccant 

Cooling N/A Refer to Initial SNAP Rule, SNAP Notice 5 and SNAP Notice 25.

Evaporative 

Cooling N/A Refer to SNAP Notice 5 and SNAP Notice 25.

HFC-134a

R-134a;

1,1,1,2-

tetrafluoroethane; 

CAS # 811-97-2

Refer to SNAP Rule 20, SNAP Notice 10, and SNAP Notice 25.

HFC-32 R-32; difluoromethane; 

CAS # 75-10-5 Refer to SNAP Rule 19.

HFC-125/HFC134a/HC-600a 

(28.1/70/1.9)

NU-22 old composition Refer to SNAP Notice 25.

ICOR AT-22

HFC-125/HC-290/HFC134a/ HC-600a; 

(55/1/42.5/ 1.5)

Refer to SNAP Notice 20 and SNAP Notice 25.
15

Substitute Name

Further Identification 

Information for 

Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability Determination 

for the ODP, GWP, VOC Status, Flammability, and Exposure Limit for Each Listed 

Substitute

KDD6 Composition is claimed 

as CBI

Refer to SNAP Notice 23.

R-290 Propane; CAS # 74-98-6 Refer to SNAP Rule 19.

R-404A

SUVA HP62; HFC125/HFC-143a/HFC134a; (44/52/ 4)

Refer to Initial SNAP Rule and SNAP Notice 17.1

R-407A

Klea 60; 

Klea 407A;

HFC-32/HFC-125/HFC134a (20/40/40);

Refer to SNAP Notice 23.

R-407C

Suva 407C; 

Klea 407C;

HFC-32/HFC-125/HFC134a; (23/25/52)

Refer to SNAP Notice 4, SNAP 17, and SNAP Notice 18. 1

R-407F

Genetron Performax LT;

HFC-32/HFC-125/HFC134a (30/30/40)

Refer to SNAP Acceptability Determination 26.

R-410A

AZ-20; 

Suva 9100; 

Puron;

HFC-32/HFC-125; 

(50/50)

Refer to SNAP Notice 4 and SNAP Notice 17. 1

R-410B HFC-32/HFC-125; 

(45/55)

Refer to SNAP Notice 4 and SNAP Notice 25.
16

Substitute Name

Further Identification 

Information for 

Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability Determination 

for the ODP, GWP, VOC Status, Flammability, and Exposure Limit for Each Listed 

Substitute

R-417A

ISCEON-59; 

NU-22 (new 

composition);

HFC-125/HFC-134a/HC600; (46.6/50/3.4)

Refer to SNAP Notice 11 and SNAP Notice 25.

R-417C

ICOR; Hot Shot 2; HFC125/HFC-134a/HC-600 

(19.5/78.8/1.7)

Refer to SNAP Acceptability Determination 26.

R-421A

Choice R-421A;

HFC-125/HFC-134a; (58/ 

42)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-422B

ICOR XAC1; ICOR NU22B; 

HFC-125/HFC-134a/HC600a; (55/42/3)

Refer to SNAP Notice 20 and SNAP Notice 25.

R-422C

ICOR XLT1; One Shot; 

HFC-125/HFC-134a/HC600a; (82/15/3)

Refer to SNAP Notice 20 and SNAP Notice 25.

R-422D

ISCEON MO29;

HFC-125/HFC-134a/HC600a; (65.1/31.5/3.4)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-424A

RS-44 (new 

formulation);

HFC-125/HFC-134a/HC600a/HC-600/HC-601a;

(50.5/47/0.9/1/0.6)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-427A

Forane 427A; HFC32/HFC-125/HFC143a/HFC-134a 

(15/25/10/50)

Refer to SNAP Notice 23 and SNAP Notice 25.
17

Substitute Name

Further Identification 

Information for 

Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability Determination 

for the ODP, GWP, VOC Status, Flammability, and Exposure Limit for Each Listed 

Substitute

R-434A

RS-45; HFC-125/HFC143a/HFC-134a/R-600a 

(63.2/18/16/2.8)

Refer to SNAP Notice 22 and SNAP Notice 25.

R-437A

ISCEON MO49 PlusTM; 

HFC-125/HFC-134a/HC600/HC-601 (19.5/78.5/ 

1.4/0.6)

Refer to SNAP Notice 25.

R-438A

KDD5; 

ISCEON MO99;

HFC-32/HFC-125/HFC134a/HC-600/HC-601a;

(8.5/45/44.2/1.7/0.6)

Refer to SNAP Notice 24 and SNAP Notice 25.

R-441A

HCR-188C;

HC-170/HC-290/HC600a/HC-600; (3.1/54.8/ 

6/36.1)

Refer to SNAP Rule 19.

R-507A HFC-125/HFC-143a; (50/ 

50)

Refer to Initial SNAP Rule, SNAP Notice 5, SNAP Notice 17, and SNAP Acceptability 

Determination 26.

RS-44 (2003 

formulation)

Composition is claimed 

as CBI

Refer to SNAP Notice 18 and SNAP Notice 25.

THR-03 Composition is claimed 

as CBI

Refer to SNAP Notice 11.

 1 Refer to IPCC Fourth Assessment Report for GWP value.
18

5 CHILLERS

The references to environmental and health properties of acceptable substitutes, substitutes acceptable subject to use conditions, and 

substitutes whose status would change under the final rule for new chillers are summarized in the table below. (Substitutes previously listed as 

unacceptable are not included here.)

 Table 5. Environmental and Health Properties of Refrigerants in Chillers1

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and Exposure 

Limit for Each Listed Substitute

Ammonia 

Absorption R-717 Refer to SNAP Notice 5 and SNAP Notice 25.

Ammonia Vapor 

Compression R-717 Refer to SNAP Notice 5 and SNAP Notice 25.

Desiccant 

Cooling N/A Refer to Initial SNAP Rule, SNAP Notice 5, and SNAP Notice 25.

Evaporative 

Cooling N/A Refer to SNAP Notice 5 and SNAP Notice 25.

FOR12A Composition is claimed as CBI Refer to SNAP Notice 14. 

FOR12B Composition is claimed as CBI Refer to SNAP Notice 14. 

HFC-134a

HFC-134a;

1,1,1,2-tetrafluoroethane; 

CAS # 811-97-2

Refer to SNAP Rule 20, SNAP Notice 10, and SNAP Notice 25.
19

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and Exposure 

Limit for Each Listed Substitute

HFC-227ea

1,1,1,2,3,3,3-

heptafluoropropane;

CAS # 431-89-0

Refer to SNAP Notice 10 and SNAP Notice 25.2

HFC-236fa

1,1,1,3,3,3-hexafluoropropane; 

CAS # 690-39-1 Refer to SNAP Notice 4, SNAP Notice 6, and SNAP Notice 10.

HFC-245fa

Gentron®245fa; 

1,1,1,3,3-pentafluoropropane; 

CAS # 460-73-1 Refer to SNAP Notice 13, SNAP Notice 20, and SNAP Notice 25.

HFO-1234ze(E)

trans-1,3,3,3-tetrafluoroprop1-ene;

CAS # -29118-24-9

Refer to SNAP Notice 24 and SNAP Notice 25.

Ikon A

Ikon 12;

Blend Zeta; 

Composition is claimed as CBI

Refer to SNAP Notice 13.2

Ikon B Composition is claimed as CBI Refer to SNAP Notice 13. 

R-423A Isceon 39TC; Centri-Cool; HFC134a/HFC-227ea; (52.5/47.5) Refer to SNAP Notice 25.

KDD6 Composition is claimed as CBI Refer to SNAP Notice 23.

R-407C

Suva 407C; 

Klea 407C;

HFC-32/HFC-125/HFC-134a; 

(23/25/52)

Refer to SNAP Notice 4, SNAP 17, and SNAP Notice 18.2
20

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and Exposure 

Limit for Each Listed Substitute

R-417C

ICOR; Hot Shot 2; HFC125/HFC-134a/HC-600 

(19.5/78.8/1.7)

Refer to SNAP Acceptability Determination 26.

R-422C

ICOR XLT1; One Shot; 

HFC-125/HFC-134a/HC-600a; 

(82/15/3)

Refer to SNAP Notice 20 and SNAP Notice 25.

R-426A

RS-24 (new formulation);

HFC-125/HFC-134a/HC600/HC-601a (5.1/93/ 1.3/0.6)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-450A

Solstice® N–13; 

HFC-134a/HFO-1234ze(E); 

(42/58)

Refer to SNAP Acceptability Determination 29.

RS-24 (2002 

formulation) Composition is claimed as CBI Refer to SNAP Notice 17 and SNAP Notice 25.

SP34E Composition is claimed as CBI Refer to SNAP Notice 14, SNAP Notice 15, and SNAP Notice 25.

THR-02 Composition is claimed as CBI Refer to SNAP Notice 11.

Trans-1-chloro3,3,3-trifluoroprop-1-ene

Solstice 1233zd(E); 

CAS # 102687-65-0

Refer to SNAP Acceptability Determination 27.

Water/Lithium 

Bromide 

Absorption

N/A Refer to Initial SNAP Rule, SNAP Notice 5, and SNAP Notice 25.

1 HCFC-22 and several blends containing HCFCs are also listed as acceptable but their use is severely restricted by the phasedown in HCFC production and 

consumption.

 2Refer to IPCC Fourth Assessment Report for GWP value.
21

6 HOUSEHOLD REFRIGERATORS AND FREEZERS

The references to environmental and health properties of acceptable substitutes, substitutes acceptable, subject to use conditions, and 

substitutes whose status would change under the final rule for new household refrigerators and freezers are summarized in the table below. 

(Substitutes previously listed as unacceptable are not included here.)

 Table 6. Environmental and Health Properties of Refrigerants in Household Refrigerators and Freezers1

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and Exposure 

Limit for Each Listed Substitute

Ammonia 

Absorption R-717 Refer to SNAP Notice 5 and SNAP Notice 25.

FOR12A Composition is claimed as CBI Refer to SNAP Notice 14. 

FOR12B Composition is claimed as CBI Refer to SNAP Notice 14. 

HFC-134a 1,1,1,2-tetrafluoroethane;

CAS # 811-97-2

Refer to SNAP Rule 20, SNAP Notice 10, and SNAP Notice 25.

HFC-152a 1,1-difluoroethane; 

CAS # 75-34-3

Refer to SNAP Rule 14 and SNAP Notice 25.

Ikon A

Ikon 12;

Blend Zeta; 

Composition is claimed as CBI

Refer to SNAP Notice 13.2
22

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and Exposure 

Limit for Each Listed Substitute

Ikon B Composition is claimed as CBI Refer to SNAP Notice 13.2

KDD6 Composition is claimed as CBI Refer to SNAP Notice 23.

R-290 Propane; CAS # 74-98-6 Refer to SNAP Rule 19.

R-404A SUVA HP62; HFC-125/HFC143a/HFC-134a; (44/52/ 4)

Refer to Initial SNAP Rule and SNAP Notice 17.2

R-407C

Suva 407C; 

Klea 407C;

HFC-32/HFC-125/HFC-134a; 

(23/25/52)

Refer to SNAP Notice 4, SNAP 17, and SNAP Notice 18.2

R-421B HFC-125/HFC-134a; (85/15) Refer to SNAP Notice 21 and SNAP Notice 25.

R-422C

ICOR XLT1; One Shot; 

HFC-125/HFC-134a/HC-600a; 

(82/15/3)

Refer to SNAP Notice 20 and SNAP Notice 25.

R-426A

RS-24 (new formulation);

HFC-125/HFC-134a/HC600/HC-601a (5.1/93/ 1.3/0.6)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-441A

HCR-188C;

HC-170/HC-290/HC-600a/HC600; (3.1/54.8/ 6/36.1)

Refer to SNAP Rule 17.
23

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and Exposure 

Limit for Each Listed Substitute

R-450A

Solstice® N–13; 

HFC-134a/HFO-1234ze(E); 

(42/58)

Refer to SNAP Acceptability Determination 29.

R-600a 2-methylpropane; isobutane Refer to SNAP Rule 17.

RS-24 (2002 

formulation) Composition is claimed as CBI Refer to SNAP Notice 17 and SNAP Notice 25.

SP34E Composition is claimed as CBI Refer to SNAP Notice 14 and SNAP Notice 25.

THR-01 Composition is claimed as CBI Refer to SNAP Notice 8.

THR-02 Composition is claimed as CBI Refer to SNAP Notice 11.

 1 HCFC-22 and several blends containing HCFCs are also listed as acceptable but their use is severely restricted by the phasedown in HCFC production 

 and consumption.

 2Refer to IPCC Fourth Assessment Report for GWP value.
24

7 FIRE SUPPRESSION AND EXPLOSION PROTECTION

The references to environmental and health properties of acceptable substitutes, substitutes acceptable, subject to use conditions or 

narrowed use limits, and substitutes whose status would change under the final rule for fire suppression and explosion protection are 

summarized in the table below. (Substitutes previously listed as unacceptable are not included here.)

 Table 7. Environmental and Health Properties of Alternatives in Fire Suppression and Explosion Protection1

Substitute Name Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, and Exposure Limit 

for Each Listed Substitute

C6-perfluoroketone

1,1,1,2,2,4,5,5,5-nonafluoro-4-

(trifluoromethyl)-3-pentanone; 

Novec 1230

Refer to SNAP Rule 11 and SNAP Notice 17.

C7 Fluoroketone C7 FK; FK-6-1-14 Refer to SNAP Rule 18.

ATK OS-10

Gas generators suppress fire 

through production of water 

vapor and N2; CAS# 7727-37-9

Refer to SNAP Notice 23.

Carbon Dioxide

R-744; 

CO2;

CAS # 124-38-9

Refer to Initial SNAP Rule and SNAP Rule 14.

C3F8 PFC-218; CEA-308 Refer to SNAP Rule 1 and SNAP Rule 4.2

C4F10 PFC-410; CEA-410 Refer to SNAP Rule 1 and SNAP Rule 4.2

C6F14 PFC-614; CEA-614 Refer to SNAP Rule 4.2
25

Substitute Name Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, and Exposure Limit 

for Each Listed Substitute

CF3l CAS# 2314-97-8 Refer to SNAP Rule 1, SNAP Rule 2, and SNAP Rule 9.2

Dry Chemical

Powdered solids such as 

sodium bicarbonate or 

ammonium polyphosphate

Refer to Initial SNAP Rule.

Firebane®1115 N/A Refer to SNAP Acceptability Determination 26.

Firebane®1170 N/A Refer to SNAP Acceptability Determination 26.

Firebane®1179 N/A Refer to SNAP Acceptability Determination 26

Firebane® All-Weather 

1115 N/A Refer to SNAP Acceptability Determination 26.

Foam N/A Refer to Initial SNAP Rule.

Foam A

Formerly Water 

Mist/Surfactant Blend A; 

Phirex+

Refer to SNAP Notice 5.

Gelled Halocarbon/Dry 

Chemical Suspension

Initially listed as Powdered 

Aerosol B Refer to SNAP Rule 1 and SNAP Notice 1.
26

Substitute Name Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, and Exposure Limit 

for Each Listed Substitute

Gelled Halocarbon/Dry 

Chemical Suspension 

(Envirogel) with 

ammonium 

polyphosphate additive

N/A Refer to SNAP Rule 9.

Gelled Halocarbon /Dry 

Chemical Suspension 

(Envirogel) with any 

additive other than 

ammonium 

polyphosphate or 

sodium bicarbonate

N/A Refer to SNAP Rule 9.

Gelled Halocarbon /Dry 

Chemical Suspension 

with sodium 

bicarbonate (Envirogel 

B25 + 36)

N/A Refer to SNAP Rule 15.

H Galden HFPEs N/A Refer to SNAP Rule 11.

Halotron II N/A Refer to SNAP Rule 9.

HCFC-123

2,2-dichloro- 1,1,1-

trifluoroethane; CAS# 306-83-

2; FE-232 Refer to SNAP Notice 1.

HCFC-124

2-chloro-1,1,1,2-

tetrafluoroethane; FE-241; CAS 

# 2837-89-0 Refer to Initial SNAP Rule and SNAP Notice 1.2
27

Substitute Name Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, and Exposure Limit 

for Each Listed Substitute

HCFC-22 Chlorodifluoromethane;

CAS# 75-45-6

Refer to SNAP Rule 20 and SNAP Notice 25.

[HCFC Blend] A NAF S-III Refer to Initial SNAP Rule.

[HCFC Blend] B Halotron 1 Refer to Initial SNAP Rule.

[HCFC Blend] C NAF P-III Refer to SNAP Notice 1.

[HCFC Blend] D Blitz III Refer to SNAP Notice 1.

[HCFC Blend] E NAF P-IV Refer to SNAP Rule 6.

HFC-125 1,1,1,2,2-pentafluoropropane;

FE 25; CAS # 354-33-6

Refer to Initial SNAP Rule and SNAP Notice 25.2

HFC-125 with 0.1% dlimonene NAF S-125 Refer to SNAP Notice 18.

HFC-134a 1,1,1,2-tetrafluoroethane;

CAS # 811-97-2

Refer to Initial SNAP Rule, SNAP Notice 10, and SNAP Notice 25.
28

Substitute Name Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, and Exposure Limit 

for Each Listed Substitute

HFC227-BC HFC-227ea used together with 

sodium bicarbonate Refer to SNAP Rule 11.

HFC-227ea

1,1,1,2,3,3,3-

heptafluoropropane;

FM-200; FE-227; CAS # 431-89-

0

Refer to SNAP Notice 10 and SNAP Notice 25.2

HFC-227ea with 0.1% dlimonene NAF S 227 Refer to SNAP Notice 19.

HFC-23 trifluoromethane; CHF3; 

CAS #75-46-7 Refer to Initial SNAP Rule, SNAP Notice 1 and SNAP Notice 10.2

HFC-236fa

1,1,1,3,3,3-hexafluoropropane; 

FE-36; CAS # 690-39-1 Refer to SNAP Notice 4, SNAP Notice 6, and SNAP Notice 10. 2

IG-01 Argotec; formerly Inert Gas 

Blend C Refer to SNAP Notice 3.

IG-100 NN-100 Refer to SNAP Rule 6.

IG-541 Inergen Refer to Initial SNAP Rule.

Inert Gas/Powdered 

Aerosol Blend FS 0140 Refer to SNAP Rule 1.
29

Substitute Name Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, and Exposure Limit 

for Each Listed Substitute

N2 Towers® System N/A Refer to SNAP Acceptability Determination 26.

Phosphorus tribromide PhostrEx Refer to SNAP Rule 15.

Powdered Aerosol A SFE Refer to Initial SNAP Rule.

Powdered Aerosol C PyroGen; Soyuz Refer to SNAP Notice 4.

Powdered Aerosol D Aero K/Stat X Refer to SNAP Rule 15.

Powdered Aerosol E Fire Pro Refer to SNAP Rule 15.

Powdered Aerosol F KSA® Refer to SNAP Rule 18.

Powdered Aerosol G

Dry Sprinkler Powdered 

Aerosol (DPSA) Fixed 

Generators

Refer to SNAP Rule 15.

SF6 Sulfur hexafluoride Refer to SNAP Rule 9.
30

Substitute Name Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, and Exposure Limit 

for Each Listed Substitute

Solution of 50% 

potassium acetate and 

50% water

K-Ace Refer to SNAP Acceptability Determination 28.

[Surfactant Blend] A Cold Fire; FlameOut; Fire Strike Refer to SNAP Acceptability Determination 27.

Uni-light Advanced Fire 

Fighting Foam 1% 

water mist system

Uni-light AFFF 1% Refer to SNAP Notice 20.

Victaulic Vortex 

Systems N/A Refer to SNAP Notice 23.

Water H2O;

CAS # 7732-18-5

Refer to Initial SNAP Rule and SNAP Notice 10.

Water Mist Systems 

using Potable or 

Natural Sea Water

N/A Refer to SNAP Notice 3.

 1All substitutes listed in this end-use are nonflammable. 2Refer to IPCC Fourth Assessment Report for GWP value.
31

8 COMMERCIAL ICE MACHINES

The references to environmental and health properties of acceptable substitutes and substitutes acceptable subject to use conditions for

new commercial ice machines are summarized in the table below. (Substitutes previously listed as unacceptable are not included here.)

 Table 8. Environmental and Health Properties of Refrigerants in Commercial Ice Machines1

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and Exposure 

Limit for Each Listed Substitute

Ammonia 

Absorption R-717 Refer to SNAP Notice 5 and SNAP Notice 25.

Ammonia Vapor 

Compression R-717 Refer to SNAP Notice 5 and SNAP Notice 25.

FOR12A Composition is claimed as CBI Refer to SNAP Notice 14. 

FOR12B Composition is claimed as CBI Refer to SNAP Notice 14. 

HFC-134a 1,1,1,2-tetrafluoroethane;

CAS # 811-97-2

Refer to SNAP Rule 20, SNAP Notice 10, and SNAP Notice 25.

ICOR AT-22 HFC-125/HC-290/HFC-134a/

HC-600a; (55/1/42.5/ 1.5)

Refer to SNAP Notice 20 and SNAP Notice 25.
32

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and Exposure 

Limit for Each Listed Substitute

Ikon A

Ikon 12;

Blend Zeta; 

Composition is claimed as CBI

Refer to SNAP Notice 13.2

Ikon B Composition is claimed as CBI Refer to SNAP Notice 13. 

KDD6 Composition is claimed as CBI Refer to SNAP Notice 23.

R-404A SUVA HP62; HFC-125/HFC143a/HFC-134a; (44/52/ 4)

Refer to Initial SNAP Rule and SNAP Notice 17.2

R-407A

Klea 60; 

Klea 407A;

HFC-32/HFC-125/HFC-134a 

(20/40/40);

Refer to SNAP Notice 1, SNAP Notice 23, and SNAP Notice 25.

R-407B

Klea 61;

HFC-32/HFC-125/HFC-134a; 

(10/70/20)

Refer to SNAP Notice 1 and SNAP Notice 25.

R-407C

Suva 407C; 

Klea 407C;

HFC-32/HFC-125/HFC-134a; 

(23/25/52)

Refer to SNAP Notice 4, SNAP 17, and SNAP Notice 18.2

R-407F

Genetron Performax LT;

HFC-32/HFC-125/HFC-134a 

(30/30/40)

Refer to SNAP Acceptability Determination 26.
33

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and Exposure 

Limit for Each Listed Substitute

R-410A

AZ-20; 

Suva 9100; 

Puron;

HFC-32/HFC-125; (50/50)

Refer to SNAP Notice 4 and SNAP Notice 17.2

R-410B HFC-32/HFC-125; (45/55) Refer to SNAP Notice 4 and SNAP Notice 25.

R-417A

ISCEON-59; 

NU-22 (new composition);

HFC-125/HFC-134a/HC-600; 

(46.6/50/3.4)

Refer to SNAP Notice 11 and SNAP Notice 25.

R-417C

ICOR; Hot Shot 2; HFC125/HFC-134a/HC-600 

(19.5/78.8/1.7)

Refer to SNAP Acceptability Determination 26.

R-421A Choice R-421A;

HFC-125/HFC-134a; (58/ 42)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-421B HFC-125/HFC-134a; (85/15) Refer to SNAP Notice 21 and SNAP Notice 25.

R-422A

ISCEON 79;

HFC-125/HFC-134a/HC-600a; 

(85.1/11.5/3.4)

Refer to SNAP Notice 19.2

R-422B

ICOR XAC1; ICOR NU-22B; 

HFC-125/HFC-134a/HC-600a; 

(55/42/3)

Refer to SNAP Notice 20 and SNAP Notice 25.

R-422C

ICOR XLT1; One Shot; 

HFC-125/HFC-134a/HC-600a; 

(82/15/3)

Refer to SNAP Notice 20 and SNAP Notice 25.
34

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and Exposure 

Limit for Each Listed Substitute

R-422D

ISCEON MO29;

HFC-125/HFC-134a/HC-600a; 

(65.1/31.5/3.4)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-424A

RS-44 (new formulation);

HFC-125/HFC-134a/HC600a/HC-600/HC-601a;

(50.5/47/0.9/1/0.6)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-426A

RS-24 (new formulation);

HFC-125/HFC-134a/HC600/HC-601a (5.1/93/ 1.3/0.6)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-434a

RS-45; HFC-125/HFC143a/HFC-134a/R-600a 

(63.2/18/16/2.8)

Refer to SNAP Notice 22 and SNAP Notice 25.

R-438A

KDD5; 

ISCEON MO99;

HFC-32/HFC-125/HFC134a/HC-600/HC-601a;

(8.5/45/44.2/1.7/0.6)

Refer to SNAP Notice 24 and SNAP Notice 25.

R-441A

HCR-188C;

HC-170/HC-290/HC-600a/HC600; (3.1/54.8/ 6/36.1)

Refer to SNAP Rule 17.

R-450A

Solstice® N–13; 

HFC-134a/HFO-1234ze(E); 

(42/58)

Refer to SNAP Acceptability Determination 29.

R-507A HFC-125/HFC-143a; (50/ 50)

Refer to Initial SNAP Rule, SNAP Notice 5, SNAP Notice 17, and SNAP 

Acceptability Determination 26.
35

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and Exposure 

Limit for Each Listed Substitute

RS-24 (2002 

formulation) Composition is claimed as CBI Refer to SNAP Notice 17 and SNAP 25.

RS-44 (2003 

formulation) Composition is claimed as CBI Refer to SNAP Notice 18 and SNAP Notice 25.

Stirling Cycle N/A Refer to Initial SNAP Rule and SNAP Notice 25.

THR-02 Composition is claimed as CBI Refer to SNAP Notice 11.

THR-03 Composition is claimed as CBI Refer to SNAP Notice 11.

THR-04 Composition is claimed as CBI Refer to SNAP Notice 10.

 1HCFC-22 and several blends containing HCFCs are also listed as acceptable but their use is severely restricted by the phasedown in HCFC production 

 and consumption.

 2Refer to IPCC Fourth Assessment Report for GWP value.
36

9 WATER COOLERS

The references to environmental and health properties of acceptable substitutes and substitutes acceptable, subject to use conditions, for

new water coolers are summarized in the table below. (Substitutes previously listed as unacceptable are not included here.)

 Table 9. Environmental and Health Properties of Refrigerants in Water Coolers1

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

FOR12A Composition is claimed as CBI Refer to SNAP Notice 14. 

FOR12B Composition is claimed as CBI Refer to SNAP Notice 14. 

HFC-134a 1,1,1,2-tetrafluoroethane;

CAS # 811-97-2

Refer to SNAP Rule 20, SNAP Notice 10, and SNAP Notice 25.

ICOR AT-22 HFC-125/HC-290/HFC-134a/ HC600a; (55/1/42.5/ 1.5)

Refer to SNAP Notice 20 and SNAP Notice 25.

Ikon A

Ikon 12;

Blend Zeta; 

Composition is claimed as CBI

Refer to SNAP Notice 13.2

Ikon B Composition is claimed as CBI Refer to SNAP Notice 13.2

KDD6 Composition is claimed as CBI Refer to SNAP Notice 23.
37

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

R-404A SUVA HP62; HFC-125/HFC143a/HFC-134a; (44/52/ 4)

Refer to Initial SNAP Rule and SNAP Notice 17.2

R-407B

Klea 61;

HFC-32/HFC-125/HFC-134a; 

(10/70/20)

Refer to SNAP Notice 1 and SNAP Notice 25.

R-407C

Suva 407C; 

Klea 407C;

HFC-32/HFC-125/HFC-134a; 

(23/25/52)

Refer to SNAP Notice 4, SNAP 17, and SNAP Notice 18.2

R-410A

AZ-20; 

Suva 9100; 

Puron;

HFC-32/HFC-125; (50/50)

Refer to SNAP Notice 4 and SNAP Notice 17.2

R-410B HFC-32/HFC-125; (45/55) Refer to SNAP Notice 4 and SNAP Notice 25.

R-417A

ISCEON-59; 

NU-22 (new composition);

HFC-125/HFC-134a/HC-600; 

(46.6/50/3.4)

Refer to SNAP Notice 11 and SNAP Notice 25.

R-421A Choice R-421A;

HFC-125/HFC-134a; (58/ 42)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-422B

ICOR XAC1; ICOR NU-22B; 

HFC-125/HFC-134a/HC-600a;

(55/42/3)

Refer to SNAP Notice 20 and SNAP Notice 25.

R-422C

ICOR XLT1; One Shot; 

HFC-125/HFC-134a/HC-600a; 

(82/15/3)

Refer to SNAP Notice 20 and SNAP Notice 25.
38

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

R-422D

ISCEON MO29;

HFC-125/HFC-134a/HC-600a; 

(65.1/31.5/3.4)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-426A

RS-24 (new formulation);

HFC-125/HFC-134a/HC-600/HC601a (5.1/93/ 1.3/0.6)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-434a RS-45; HFC-125/HFC-143a/HFC134a/R-600a (63.2/18/16/2.8) Refer to SNAP Notice 22 and SNAP Notice 25.

R-438A

KDD5; 

ISCEON MO99;

HFC-32/HFC-125/HFC-134a/HC600/HC-601a;

(8.5/45/44.2/1.7/0.6)

Refer to SNAP Notice 24 and SNAP Notice 25.

R-450A

Solstice® N–13; 

HFC-134a/HFO-1234ze(E); 

(42/58)

Refer to SNAP Acceptability Determination 29.

R-507A HFC-125/HFC-143a; (50/ 50)

Refer to Initial SNAP Rule, SNAP Notice 5, SNAP Notice 17, and SNAP 

Acceptability Determination 26.

RS-24 (2002 

formulation) Composition is claimed as CBI Refer to SNAP Notice 17 and SNAP 25.

THR-02 Composition is claimed as CBI Refer to SNAP Notice 11.

THR-04 Composition is claimed as CBI Refer to SNAP Notice 10.

 1 HCFC-22 and several blends containing HCFCs are also listed as acceptable but their use is severely restricted by the phasedown in HCFC production 

 and consumption.

 2Refer to IPCC Fourth Assessment Report for GWP value.
39

10 COLD STORAGE WAREHOUSES

The references to environmental and health properties of acceptable substitutes, substitutes acceptable, subject to use conditions, and 

substitutes whose status would change under the final rule for new cold storage warehouses are summarized in the table below. 

(Substitutes previously listed as unacceptable are not included here.)

 Table 10. Environmental and Health Properties of Refrigerants in Cold Storage Warehouses1

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

Ammonia 

Absorption R-717 Refer to SNAP Notice 5 and SNAP Notice 25.

Ammonia Vapor 

Compression R-717 Refer to SNAP Notice 5 and SNAP Notice 25.

Carbon Dioxide

R-744;

CO2; 

CAS # 124-38-9

Refer to SNAP Rule 14 and SNAP Notice 24. 

Desiccant 

Cooling N/A Refer to Initial SNAP Rule, SNAP Notice 5 and SNAP Notice 25.

Evaporative 

Cooling N/A Refer to Initial SNAP Rule. 

FOR12A Composition is claimed as CBI Refer to SNAP Notice 14. 
40

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

FOR12B Composition is claimed as CBI Refer to SNAP Notice 14. 

HFC-134a 1,1,1,2-tetrafluoroethane;

CAS # 811-97-2

Refer to SNAP Rule 20, SNAP Notice 10, and SNAP Notice 25.

HFC-134a/HBr 

(92/8) as the 

primary heat 

transfer fluid in 

secondary-loop 

equipment

N/A Refer to SNAP Notice 15.

HFC-227ea

1,1,1,2,3,3,3-

heptafluoropropane;

CAS # 431-89-0

Refer to SNAP Notice 10 and SNAP Notice 25. 

ICOR AT-22 HFC-125/HC-290/HFC-134a/ HC600a; (55/1/42.5/ 1.5)

Refer to SNAP Notice 20 and SNAP Notice 25.

Ikon A

Ikon 12;

Blend Zeta; 

Composition is claimed as CBI

Refer to SNAP Notice 13.2

Ikon B Composition is claimed as CBI Refer to SNAP Notice 13.2

R-423A Isceon 39TC; Centri-Cool; HFC134a/HFC-227ea; (52.5/47.5) Refer to SNAP Notice 25.
41

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

KDD6 Composition is claimed as CBI Refer to SNAP Notice 23.

Pressure 

Stepdown N/A Refer to Initial SNAP Rule and SNAP Notice 25.

R-404A SUVA HP62; HFC-125/HFC143a/HFC-134a; (44/52/ 4) Refer to Initial SNAP Rule and SNAP Notice 2.2

R-407A

Klea 60; 

Klea 407A;

HFC-32/HFC-125/HFC-134a 

(20/40/40);

Refer to SNAP Notice 1, SNAP Notice 23, and SNAP Notice 25.

R-407B

Klea 61;

HFC-32/HFC-125/HFC-134a; 

(10/70/20)

Refer to SNAP Notice 1 and SNAP Notice 25.

R-407C

Suva 407C; 

Klea 407C;

HFC-32/HFC-125/HFC-134a; 

(23/25/52)

Refer to SNAP Notice 4, SNAP 17, and SNAP Notice 18.2

R-407F

Genetron Performax LT;

HFC-32/HFC-125/HFC-134a 

(30/30/40)

Refer to SNAP Acceptability Determination 26.

R-410A

AZ-20; 

Suva 9100; 

Puron;

HFC-32/HFC-125; (50/50)

Refer to SNAP Notice 4 and SNAP Notice 17.2
42

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

R-410B HFC-32/HFC-125; (45/55) Refer to SNAP Notice 4 and SNAP Notice 25.

R-417A

ISCEON-59; 

NU-22 (new composition);

HFC-125/HFC-134a/HC-600; 

(46.6/50/3.4)

Refer to SNAP Notice 11 and SNAP Notice 25.

R-417C ICOR; Hot Shot 2; HFC-125/HFC134a/HC-600 (19.5/78.8/1.7)

Refer to SNAP Acceptability Determination 26.

R-421A Choice R-421A;

HFC-125/HFC-134a; (58/ 42)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-421B Choice R-421B; HFC-125/HFC134a; (85/15) Refer to SNAP Notice 21 and SNAP Notice 25.

R-422A

ISCEON 79;

HFC-125/HFC-134a/HC-600a; 

(85.1/11.5/3.4)

Refer to SNAP Notice 19.2

R-422B

ICOR XAC1; ICOR NU-22B; 

HFC-125/HFC-134a/HC-600a; 

(55/42/3)

Refer to SNAP Notice 20 and SNAP Notice 25.

R-422C

ICOR XLT1; One Shot; 

HFC-125/HFC-134a/HC-600a; 

(82/15/3)

Refer to SNAP Notice 20 and SNAP Notice 25.

R-422D

ISCEON MO29;

HFC-125/HFC-134a/HC-600a; 

(65.1/31.5/3.4)

Refer to SNAP Notice 21 and SNAP Notice 25.
43

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

R-424A

RS-44 (new formulation);

HFC-125/HFC-134a/HC600a/HC-600/HC-601a;

(50.5/47/0.9/1/0.6)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-426A

RS-24 (new formulation);

HFC-125/HFC-134a/HC-600/HC601a (5.1/93/ 1.3/0.6)

Refer to SNAP Notice 21 and SNAP Notice 25.

R-434A RS-45; HFC-125/HFC-143a/HFC134a/R-600a (63.2/18/16/2.8) Refer to SNAP Notice 22 and SNAP Notice 25.

R-438A

KDD5; 

ISCEON MO99;

HFC-32/HFC-125/HFC-134a/HC600/HC-601a;

(8.5/45/44.2/1.7/0.6)

Refer to SNAP Notice 24 and SNAP Notice 25.

R-450A

Solstice® N–13; 

HFC-134a/HFO-1234ze(E); 

(42/58)

Refer to SNAP Acceptability Determination 29.

R-507A HFC-125/HFC-143a; (50/ 50)

Refer to Initial SNAP Rule, SNAP Notice 5, SNAP Notice 17, and SNAP 

Acceptability Determination 26.

RS-24 (2002 

formulation) Composition is claimed as CBI Refer to SNAP Notice 17 and SNAP Notice 25.

RS-44 (2003 

formulation) Composition is claimed as CBI Refer to SNAP Notice 18 and SNAP Notice 25.
44

Substitute 

Name

Further Identification 

Information for Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability 

Determination for the ODP, GWP, VOC Status, Flammability, and 

Exposure Limit for Each Listed Substitute

Self-Chilling cans 

using CO2

N/A Refer to SNAP Notice 8 and SNAP Notice 25.

Self-Chilling cans 

using recycled 

CO2

N/A Refer to SNAP Notice 8 and SNAP Notice 25.

SP34E Composition is claimed as CBI Refer to SNAP Notice 14 and SNAP Notice 25.

Stirling Cycle N/A Refer to Initial SNAP Rule and SNAP Notice 25.

THR-02 Composition is claimed as CBI Refer to SNAP Notice 11.

THR-04 Composition is claimed as CBI Refer to SNAP Notice 10.

 1HCFC-22 and several blends containing HCFCs are also listed as acceptable but their use is severely restricted by the phasedown in HCFC production and consumption.

 2Refer to IPCC Fourth Assessment Report for GWP value.
45

11 VERY LOW TEMPERATURE REFRIGERATION

The references to environmental and health properties of acceptable substitutes and substitutes acceptable, subject to use conditions, for

very low temperature refrigeration are summarized in the table below. (Substitutes previously listed as unacceptable are not included here.)

 Table 11. Environmental and Health Properties of Refrigerants in Very Low Temperature Refrigeration1

Substitute 

Name

Further Identification 

Information for 

Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability Determination 

for the ODP, GWP, VOC Status, Flammability, and Exposure Limit for Each Listed 

Substitute

Carbon Dioxide

R-744;

CO2; 

CAS # 124-38-9

Refer to SNAP Rule 14 and SNAP Notice 24. 

HFC-23 trifluoromethane; CHF3; 

CAS #75-46-7 Refer to Initial SNAP Rule, SNAP Notice 1 and SNAP Notice 10.

HFC-245fa

1,1,1,3,3-

pentafluoroethane;

CAS # 460-73-1

Refer to SNAP Notice 11, SNAP Notice 18, and SNAP Notice 25.

HFE-7000 N/A Refer to SNAP Notice 16 and SNAP Notice 25.

HFE-7100 as a 

secondary heat 

transfer fluid in 

not-in-kind 

systems

N/A Refer to SNAP Notice 14 and SNAP Notice 25.

HFE-7200 as a 

secondary heat 

transfer fluid in 

not-in-kind 

systems

N/A Refer to SNAP Notice 14 and SNAP Notice 25.
46

Substitute 

Name

Further Identification 

Information for 

Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability Determination 

for the ODP, GWP, VOC Status, Flammability, and Exposure Limit for Each Listed 

Substitute

ICOR AT-22

HFC-125/HC-290/HFC134a/ HC-600a; 

(55/1/42.5/ 1.5)

Refer to SNAP Notice 20 and SNAP Notice 25.

ISCEON 89

Rhodia Isceon 89; HFC125/HC-290/PFC-218; 

(86/5/9)

Refer to SNAP Notice 18.

NARM-502 N/A Refer to SNAP Notice 5.

PFC-330ST, PFC550HC, PFC660HC, PFC1100HC, PFC1100LT, PGC100, PGC-150, 

PFC-331ST, PFC551HC, PFC661HC, PFC1101HC, and 

PGC-151

N/A Refer to SNAP Notice 15.

PFC-1102HC, 

PFC-662HC, PFC552HC, and FLC15

N/A Refer to SNAP Notice 16.

R-170 Ethane; CAS # 60-29-7 Refer to SNAP Rule 19.

R-404A

SUVA HP62; HFC125/HFC-143a/HFC134a; (44/52/ 4)

Refer to Initial SNAP Rule and SNAP Notice 17.2
47

Substitute 

Name

Further Identification 

Information for 

Substitute

Reference to the Applicable SNAP Rule, Notice, Or Acceptability Determination 

for the ODP, GWP, VOC Status, Flammability, and Exposure Limit for Each Listed 

Substitute

R-410A

AZ-20; 

Suva 9100; 

Puron;

HFC-32/HFC-125; 

(50/50)

Refer to SNAP Notice 4 and SNAP Notice 17.2

R-403B ISCEON 69-L Refer to SNAP Rule 1 and SNAP Notice 1.

R-407C

Suva 407C; 

Klea 407C;

HFC-32/HFC-125/HFC134a; (23/25/52)

Refer to SNAP Notice 4, SNAP Notice 17, and SNAP Notice 18.2

R-422B

ICOR XAC1; ICOR NU22B; 

HFC-125/HFC-134a/HC600a; (55/42/3)

Refer to SNAP Notice 20 and SNAP Notice 25.

R-422C

ICOR XLT1; One Shot; 

HFC-125/HFC-134a/HC600a; (82/15/3)

Refer to SNAP Notice 20 and SNAP Notice 25.

R-507A HFC-125/HFC-143a; (50/ 

50)

Refer to Initial SNAP Rule, SNAP Notice 5, SNAP Notice 17, and SNAP Acceptability 

Determination 26.

R-508A PFC Blend Alpha; KLEA 

5R3; Arcton TP5R3 Refer to SNAP Notice 1, SNAP Notice 3, and SNAP Notice 4.

R-508B SUVA 95 Refer to SNAP Notice 8.

 1HCFC-22 and several blends containing HCFCs are also listed as acceptable but their use is severely restricted by the phasedown in HCFC production and consumption.

 2Refer to IPCC Fourth Assessment Report for GWP value.
48

REFERENCES

IPCC Fourth Assessment Report. Climate Change 2007: The Physical Science Basis. Contribution of 

Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change 

[Solomon, S., D. Qin, M. Manning, Z. Chen, M. Marquis, K.B. Averyt, M.Tignor and H.L. Miller (eds.)]. 

Cambridge University Press, Cambridge, United Kingdom and New York, NY, USA.

U.S. EPA. 1994. Initial SNAP Rule. March 18, 1994. Available online at: 

http://www.epa.gov/ozone/fedregstr/59fr13044.html.

U.S. EPA. 2015. Substitutes by Sector as of October 13, 2015. Available online at 

https://www.epa.gov/snap/substitutes-sector.

U.S. EPA. 2015a. SNAP Regulations: SNAP Notices of Acceptability (Notices 1, 2, 3, 4, 5, 8, 10, 11, 12, 13, 

14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, and 30). Available online at: 

http://www.epa.gov/spdpublc/snap/regulations.html.

U.S. EPA. 2015b. SNAP Regulations: SNAP Rules (Initial SNAP Rule and Subsequent Rules 1, 4, 6, 9, 11,

14, 15, 16, 17, 18, 19, and 20). Available online at: http://www.epa.gov/spdpublc/snap/regulations.html.